LOCUS       gnlProkkaDKDDDAKN_60   14279 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DKDDDAKN_60.
ACCESSION   gnlProkkaDKDDDAKN_60
VERSION     gnlProkkaDKDDDAKN_60
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 22:37:07
            Original ID  :: gnl|Prokka|DKDDDAKN_60
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14279
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14279
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[9463:9730]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9464..9730
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14279
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14279
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             180..1028
                     /locus_tag="ctg60_1"
                     /transl_table=11
                     /translation="MNISEFNINDEFIACNHITTNELNPLVEKPYHTKASIFALCTKGV
                     LKTIINHTQFRVEANALLVIPPETFVQLLHTSDDAEIYVVIFSQQLIQSSGAGKVMMDK
                     FHIIGKHYIFPLSRTDFQLYAEFMTYLSHLYQRTESPSSLVSLQTLLTYLLQGISELCP
                     ERPRIKETPGSRHFNQYRIFIRLVHTDYVREHQVSYYALKMNMRPAALCRLVKKESGYT
                     AMEIINNTIIMDAKAQLCTANTPIKDIAVSLGFNNAAFFNKFFKRHTGIPPQKFRTSSK
                     Q"
     CDS             complement(1103..1879)
                     /NRPS_PKS="Domain: oMT (51-145). E-value: 2e-11. Score:
                     34.4. Matches aSDomain: nrpspksdomains_ctg60_2_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 81.3; E-value:
                     1.3e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg60_2"
                     /transl_table=11
                     /translation="MSNENKTIHDFEFNLICDFFSNMERQGPGSPEVTLKALSFVDGLT
                     DESLIADIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQDRVKGIVGS
                     MDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGYIAVSESSWFTDERPAEIN
                     DFWMDAYSEMDTLPNQVTKLYKAGYLPVATFILPENCWTEHYFASKVAAQEIFRKKYAG
                     NKIAEEFSLLQMIEDELYGKYKEFYGYVFFIAKKVG"
     aSDomain        complement(1445..1726)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg60_2_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.00E-11"
                     /label="ctg60_2_oMT.1"
                     /locus_tag="ctg60_2"
                     /protein_end="145"
                     /protein_start="51"
                     /score="34.4"
                     /tool="antismash"
                     /translation="DIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQD
                     RVKGIVGSMDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGY"
     CDS             complement(2114..2446)
                     /locus_tag="ctg60_3"
                     /transl_table=11
                     /translation="MKQLIACCGLDCENCAARIATVNNDDELREKTAKEWSVLNNTPEI
                     TAETIHCMGCRADGVKFTYCSDYCAIRKCVYEKGFNTCGDCKELDTCQVVGAVLQHAPG
                     ARENLY"
     CDS             3312..3638
                     /locus_tag="ctg60_4"
                     /transl_table=11
                     /translation="MKNCYGIDFRSWHKELRTREKTKQPPCKLPDRASRSLQGVLFKVY
                     QISVLILLKKILFSFFSVCLPLFIRHIAAMLLRKTSSKTMQTVTKYLKELSGVRSDNSP
                     NSYK"
     CDS             complement(3782..3955)
                     /locus_tag="ctg60_5"
                     /transl_table=11
                     /translation="MFVYPLFRPSHCPFPGYTTVTHVVCVYTIPPDGRKPYKHRREHPC
                     CYLQGNFQSCEV"
     CDS             4004..4219
                     /locus_tag="ctg60_6"
                     /transl_table=11
                     /translation="MKQNTPDGREAYITPSIEVIKMENEGVIATSGEPYHPITRSYSGS
                     TSTHSYNSASSSDLEDLINDILTVEN"
     CDS             4233..7811
                     /locus_tag="ctg60_7"
                     /transl_table=11
                     /translation="MMKLRNLMQVACMATAALTAFSCSQEEFENSGWKGNITVNATFEG
                     AGTDTRTTVNDEYKILWQDTDALGLFCSNAESNYSNTKLEYASGAGQTSATFNGSKPSG
                     ETAVFSIYPYQQNMSVSGNTLTMTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMA
                     AMIKLTVNKIPAEATTFKIIASNNIAGTCTVDLTAADPILTVASNGSKEITASFTASND
                     IKSRNFYIPLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVDAT
                     TPSALSTALADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLTFN
                     TAPTTSTAAPLTLTDKTNTSVSAPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTL
                     AAVGNKATYNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDAGDTTIYI
                     IKGTEASLPATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLD
                     LNGYTLTADNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDAS
                     MTMESGNISAVRETPDSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIIN
                     ITDGELISTADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGST
                     GNWGDGTGGLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFS
                     DPSALKYMKANANVNIKLTADKTCPGFKTTSGQTLTMDLGGKILTLADPTVGSTGTETN
                     SCQLLEGSNVTFKNGTLKSDNNKIMIQNYCNLTLDNMTVEDTNAQYVVSNNCGNISINN
                     TTINAGSNANQFAFDVCGYAKYTAGVTVTVSGTSVINGKVEISKSAGNTELMKLNITSG
                     TFNGDLKVDASVRTENAQSIISVSGGTFSDPSVLKYMATNATVDIKLLSNINIAKTKLA
                     TGYILNAANATANLNLNGHDIINSSETADATPFTQIFTVQNGTLNISGNGNVKCDASAT
                     AKDDGYRMVIEARGYGTVNIHGGSYYNTQKLNTQIDLIYARENGKINIYGGTFESGKYG
                     TPNNDTDGRYWVLNLKNTDKNTASIQVSGGTFINFNPANPNMDDNESYLVTGYEVTRDG
                     SVYTAAHKVGDGRKEYIVGQTSQENR"
     CDS             8058..8984
                     /locus_tag="ctg60_8"
                     /transl_table=11
                     /translation="MRIQILDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKV
                     IFETEIDDDETTTKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWME
                     CNDNFRQCFIHLPACRTETPAPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATET
                     GKGYLFLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTP
                     CYRKESMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVATVTEL
                     ATLAPVYHLKCLPDREATELCRKTVEG"
     CDS             9011..9451
                     /locus_tag="ctg60_9"
                     /transl_table=11
                     /translation="MKKSIPNEILLPEVARLIKEGHTVTITVRGNSMNPFLVDRRDRVT
                     LGDFTTEQLQPGVTVLARDLTERIVFHRIIRRNGDILILQGDGNLAQTEETDIGRVMGV
                     MTEAMRKDKRYTADGKVWKLYSYWWMKLNPARRWLLALFRRI"
     CDS             9464..9730
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg60_10"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1.2e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 5.6e-16, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             9739..10902
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg60_11"
                     /sec_met_domain="NTP_transf_5 (E-value: 2.7e-46, bitscore:
                     148.0, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRVLYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRYFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPATFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRSKGVKDKKARTKK"
     CDS             10925..12025
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 99.8; E-value:
                     2.6e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg60_12"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHIAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTTAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLSGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVFDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFRYTPDDRPVFSRPH"
     CDS             11994..12347
                     /locus_tag="ctg60_13"
                     /transl_table=11
                     /translation="MTVRYSAALTDPAVQAFMRKVTMHVAPEYSEKRKKDMNTWYARVE
                     ITARGQTFVEETDFSWGSNVDGYRLTEEEQKAQFRTCAAIVLPDDKIERAIGLILHLED
                     QPSLEELMSCLSL"
     CDS             12366..13832
                     /locus_tag="ctg60_14"
                     /transl_table=11
                     /translation="MVPMPEYAPPVGIDAACTNQLEGPYAPPKGIDLLCENVVNTTYDQ
                     LSEDNVRIFKDRLLDMTGCIFGGAIVPEDQFLADLLRRWGGIEEAPLFARKGRLPMPSA
                     VMLNSITARANDFGNMFFHVLGDRIASHCGETLIPMGLTLADVYPTSGREFIANNIAAE
                     DLTARILYTLPMRWPTDMLMVSSAAAALASRYYKLDAAKTKVALTYAATNATDPGNSYY
                     DYCQEFKYHNGASAQMGIMACELACGGWQGFADPYFGHWSLVTMQVKDGKPLPALYEKA
                     FEGLGQVWYTEESFKRGPGGIPTTAAAKCGAGVRQKILDDRGTLNPADIKLVRVFRSSS
                     MRFNYYSNPFTRRNHTNALFSFQFAACCALLHGAVKVELVQTPAIQADTYLVELAEHST
                     MEVFDREAGRSMMKVIVEMKDGAVYEDLQDYGGSMHDYPSREFLLQKFWDQFNAYGKLP
                     KSVGEKIVELADRIETLPDMREYTQLLTLT"
     CDS             13845..14279
                     /locus_tag="ctg60_15"
                     /transl_table=11
                     /translation="MKETYTEAPQPIEVYDKCDVLVVGSGAAGHSAAIAAARAGXXXXX
                     XXXXXSGGDVTGGYVIMVPNLSWYDKSFVRGLQEEWFTRLAPIPGAVRGPALKDIGSQD
                     PVLIDAWQSIHDCVSRGGFEGAKPSCLVRAVYYETNQRKIE"
ORIGIN
        1 cacgactgaa tattaacttt agccattatg ctgcttaatt ttgattagtt acttatattc
       61 tattattcac aactttacct tatttaacag agataagttg agcgtaatat tgattttaac
      121 tgttacctct gtcatttata cattattatc ccccattttt gcgtcttaaa atctccaaca
      181 tgaatatatc cgaattcaat ataaatgacg agttcattgc ctgcaatcat atcacaacca
      241 atgaactgaa tccgctagtg gaaaagccat accacaccaa ggccagtatc ttcgctctat
      301 gcaccaaagg agttctgaaa actatcataa accatactca attcagggtt gaagctaacg
      361 ccctcctagt tattcctccc gagaccttcg tacaattgct acacacgtca gacgatgctg
      421 aaatatatgt cgtcatattt tcccaacaac ttatccagag ttcaggggcc ggcaaggtca
      481 tgatggataa gtttcacatt ataggcaaac actatatttt tcctctatcg agaacggact
      541 tccagcttta tgccgagttc atgacctatt tgtcacacct ctaccaaaga acagaaagcc
      601 cctcaagtct agtttcattg caaactctac tgacctatct gttacaaggt atatccgaac
      661 tctgtccgga acgccctaga ataaaagaga ctccgggcag caggcatttc aaccaatacc
      721 gcatttttat ccgattggta cacacagact atgtccggga gcatcaagtg tcctattatg
      781 cattgaaaat gaatatgaga ccggcagctc tttgccgcct tgtcaaaaag gaatcaggat
      841 atacagccat ggaaatcatc aacaatacta tcatcatgga tgccaaagca caactttgta
      901 ccgccaacac tccgataaag gatatagccg tgagtctagg ttttaataat gcggccttct
      961 tcaacaaatt ctttaaacgt catacgggaa tacctcctca gaagttccgt acatcctcaa
     1021 aacaataaaa tctactcaaa acccaaaatg cggatattct gtcctgagaa tacccgcatt
     1081 cctcaataag agaagtccgt catcagccta ccttcttggc aataaagaac acataaccgt
     1141 aaaattcctt atacttgccg tacagttcat cctcaatcat ttggagtaag ctgaactctt
     1201 cggcaatttt attaccggca tatttcttac ggaaaatctc ctgagccgca acctttgaag
     1261 caaagtaatg ctctgtccag caattctccg gcaaaatgaa tgtagcaacg ggaagataac
     1321 ctgccttgta caacttggtc acctgattgg gaagtgtatc catttcagaa taggcgtcca
     1381 tccagaagtc attgatttcc gcaggacgtt cgtccgtaaa ccatgaactc tcggatacgg
     1441 caatataccc tcccggtttc agatatttac gccactcctt caagccacgt tcaaagccga
     1501 tgttatagat agcaccttca caccaaatca tatccagctc ctcctcaccg aaagggaggg
     1561 catccattga accgacaatt ccttttactc tgtcctgcaa gcccaactgc cttgcattac
     1621 ggttgaagat gtcaataaag ccggggaaaa ggtcaattcc ggtaatctgt cccggaacat
     1681 ggccagccaa taccattgtc tgaccacccg ttccacaacc gatatcggca ataagggatt
     1741 catcggtaag accgtctaca aagctcaatg ccttcaacgt cacttcagga ctgccagggc
     1801 cttgccgttc catattggag aaaaagtcac agattaaatt aaattcgaaa tcgtggatag
     1861 ttttattttc gttactcatt ttcttactat attttgcata tacggaaagt atcacaacac
     1921 cttcagcata atatgcggat taaacttgaa ttataacaat agaaaaacac tctcgaaaga
     1981 agttatccga aagtaaacga aaggggacaa tctgtgcatg gaacacagat tgtttacaaa
     2041 accaaatccg atttaaatgt ctttgtcata ctgcaaagat aagcaatatt ttatttaatc
     2101 aaagatttta cggttaataa agattttccc ttgcaccggg cgcatgctga agaaccgcac
     2161 ctaccacctg gcaagtatcc agttccttac agtcgccaca agtattgaaa cctttttcgt
     2221 acacacattt gcggatagca caataatcgc tgcaataggt aaacttcacc ccgtctgcac
     2281 ggcaccccat acaatggatg gtttccgccg taatttccgg cgtattgttc agcacactcc
     2341 actctttggc ggttttctct ctcagctcat cgtcattatt gacagtggct atacgggcgg
     2401 cgcaattttc gcaatccagt ccgcaacatg caattaattg tttcatcact tggttataac
     2461 catttatgtg tttctcatag caagcatttg tctacctcct ctttatctga atttaagagg
     2521 aggcagacag ccatgctaca aatatacggt tattattgtg tgaatgccaa attaattttc
     2581 catcactttg cttccacact tccacccacc tcctgcatcc ccctgtccat cggcatttgc
     2641 cctgcgatgg aagcaacctg aaaaggtgga agcaaaattt gcttccacct gcctgaaacg
     2701 cctgagtttt gcagtaagct gctatcccct agcataatac tgcatgcaga ttacatgaat
     2761 cggcaggttc ggttttcctg cattttcggg cttgtcctta ctgtgaagtc aacggatatg
     2821 gagttggact gtaggagcat agtaggagtt atcgggaatc aaaggccgac tatgaataat
     2881 gcactctaat gtcttttaca ccgttgtata atacgtttgc gccttgtgcg caataggttc
     2941 gggctacgta cttcatctgt aatagctctg gagttagtga cgcctaacgg ccatgaacaa
     3001 ctctgcttac ggtcgtcaaa cgattgcttt atggtcgaaa gcagggttgt tcatggccgt
     3061 taggcgtcat aaattcccta tgccacagca gacaaacaaa gggagaagag taaaggaata
     3121 cctatgtttt agataaaaat ccacaagctt tcactcgtgc tctccatagg ttatgagagc
     3181 aggcttcgcg ctctgtgcga taaattccca tttatcagca ggcatactca cttacgaaac
     3241 ttcaattact tatataaatt gtttcagcca aaggcagtac ggacatttgc aaaaatatgg
     3301 aaagtcttat tatgaaaaat tgctatggca tcgacttccg ttcgtggcat aaggagctac
     3361 gtacacgcga gaaaaccaag cagccaccct gcaaactgcc ggacagagca agccggagtt
     3421 tgcagggtgt tctgtttaaa gtatatcaaa tctctgtttt aattttgctt aaaaagattt
     3481 tattcagctt cttttcggtc tgtcttcccc tctttattcg ccacatagcc gctatgctcc
     3541 tcagaaaaac atcctcaaag acaatgcaga cagttactaa atatttgaag gagttatcgg
     3601 gagttagaag tgataactct cctaactcct ataaatgaaa gagacgtgag cctttcccaa
     3661 aaaaaataga gaaacataga tacacttaaa caaaaaacaa ttatctttgt cacaaatccg
     3721 ctatagcgta gtgggtttat ttacatatta gtaagagcat tattgaaatt atcttcttta
     3781 ttcaaacttc gcaactttga aaatttccct gaagataaca acaaggatgc tcacgtctat
     3841 gtttatatgg ttttctccca tcagggggga tagtatatac acaaacgacg tgagtgactg
     3901 ttgtatatcc agggaaaggg caatgcgaag gcctgaataa aggatataca aacatagtta
     3961 ctcacgtttt ttttattgtt taacctttaa ataatttgtg tatatgaaac agaacacacc
     4021 agacggtaga gaagcataca tcactccgtc tatcgaagtt atcaaaatgg agaatgaagg
     4081 agtcattgca acaagcggcg aaccttacca tcccattacg cgctcctatt cgggcagcac
     4141 ctctacccat agctacaatt cggcatccag cagcgacttg gaagacctaa tcaatgacat
     4201 cttaaccgta gaaaactaag ggggacttca ttatgatgaa attaagaaac cttatgcaag
     4261 ttgcctgcat ggcaactgct gccttgaccg cattcagttg cagccaagag gaatttgaaa
     4321 acagcgggtg gaaaggaaac atcaccgtta acgcaacgtt tgaaggcgca ggtaccgaca
     4381 cccgtactac cgtaaacgat gaatacaaga ttctatggca agataccgat gccctagggt
     4441 tgttctgtag taatgcagaa agtaattata gcaatacaaa attagaatat gcaagcggtg
     4501 ctggtcaaac ttccgccact ttcaacggca gcaagccaag cggagaaacg gctgtattct
     4561 ccatctatcc ttaccaacaa aacatgagcg taagcggcaa tacattgacc atgactctac
     4621 ctgccacgct tacaaattat aacggcagca gcaatggccc gatgtatgcc aaggtgacaa
     4681 atcccgacaa tctgagcgct ctgtccttca agcacatggc agccatgata aaactgaccg
     4741 tcaacaagat tccggcagag gccactactt tcaagattat tgcctccaat aacattgcag
     4801 gtacttgtac ggtagactta accgcagcag acccgatact gacggtagca agcaatggaa
     4861 gcaaggaaat cactgcctcc ttcactgctt caaacgatat aaaatcgcgc aacttctaca
     4921 ttcctttgcc cacaggtact tatagttcca tcactgccca actgacgaat ggaagcgaca
     4981 aggtatattt taccaagacg cttaatgaca aaatcttagg gagaagagac atattggtag
     5041 tacctccttt ggattgcgtt gttgtagatg ctacaacccc cagtgcgctt agtacagctt
     5101 tagctgattc aaaaaatctc ccacaagaag caccgacagc agcaaccgta accgacattg
     5161 cagtcagcgg cagcttcaat accacttctg gcagcaacga cggcatcgcc atcccggttt
     5221 tacagaactc ggacatcaac ctgacgttca atacagcccc aacgaccagt actgccgctc
     5281 cgttgacgct gaccgacaag accaatacca gcgtaagtgc tcccgccgcc actgccacca
     5341 acagtgtatc cttggctgta ccggaaacca cagcagagca agaagctcct tctgtagcca
     5401 tcaccatgcc aagcaccacc gttacattgg cagcagtagg caataaagcc acttacaatg
     5461 aagtgactgc cactaccgcc cagcagacat tgattatcaa tgcaggcgtc accgtaaaga
     5521 agctgactgt aaaaggcggt aacttgaaga tatatggaaa ggtagaacaa ttggtacacg
     5581 atgccggcga taccacaatc tatataataa aaggaactga agcatcactt ccggcaacaa
     5641 tcgacagcaa atttgtagtt caatccgacg tggcagtcct aaagaccgct ttcgccaacg
     5701 gcgaagattt taaattgtcc gccgatgccg acatcacagg gcaaagcgtc agtgtacccg
     5761 ccggaaagtc cgtggttctt gacttgaacg gatatacact gactgccgac aacagcgcaa
     5821 caggcaaaat catcgtcttg ggcaagatga cactgaagga cagctctacc gagaagaaag
     5881 gcaagatagt tgccagccag gattatacag cggcttctta taatggcagt ctgattgaaa
     5941 tagccggtga agatgcctcc atgaccatgg aaagcggcaa catcagtgca gtcagagaga
     6001 ctccggacag taacggccaa tatggcgtcg gagtgacgga cggtggagac ttcaccatga
     6061 caggcggcaa gatagaagcc ggatggtttg cagtggcagg caacggcaat tacaagacgc
     6121 agaactccat catcaacatc acagacggag aactcatttc tactgctgac tatgcagtct
     6181 atctgcccca atccggcaca acgaccatca gtggcggcaa ggtttatggt gccgcaggag
     6241 gtgtatgcat ccaacgaggc actctgaatg tggaaggtac agccttgatt accagtaaag
     6301 gcacaggtag caccggcaac tggggcgacg gtaccggagg actggactgc gccgccatca
     6361 acgtaagtgg agcatatggc attgccacag taaacatcaa aggcggtaca ctgattgccg
     6421 aagcaaagtc actcatcaca gaaggcacca cttatacacc ggtcatcaac gttaccggcg
     6481 gtacattctc cgacccaagc gcgctgaagt acatgaaggc aaatgcaaat gtgaacataa
     6541 agttgaccgc cgacaagacc tgcccgggat tcaagaccac aagcggacaa accttgacga
     6601 tggacttagg cggcaagatt cttacacttg ctgacccgac cgtaggttcc accggcaccg
     6661 aaacgaacag ctgtcaatta ctcgaaggtt caaacgttac tttcaagaac ggaacgctga
     6721 agagtgacaa caacaaaatc atgattcaga actactgcaa cctgacatta gataatatga
     6781 cagtagaaga cacaaatgcc caatacgtag taagcaacaa ttgtggcaac ataagcatca
     6841 acaataccac tatcaacgca ggaagcaatg cgaatcaatt tgcattcgac gtatgcggct
     6901 atgcaaagta cactgctgga gtcacggtta cggtaagcgg tacgagcgtc atcaatggaa
     6961 aagtggaaat ttccaagagt gcaggaaata ccgaacttat gaagctgaat atcacaagcg
     7021 gtactttcaa cggtgactta aaggtagatg catccgtgag aaccgaaaat gcccaaagta
     7081 tcatctctgt ttccggaggt acattctccg acccaagcgt actgaagtac atggcaacca
     7141 acgcaactgt ggatataaaa cttctctcaa atatcaacat cgccaagacg aagcttgcca
     7201 caggctacat attgaatgct gcaaacgcaa cggcaaactt aaacctgaat ggccacgaca
     7261 tcatcaattc ctcagaaaca gctgatgcca ctcctttcac acaaatcttt actgtacaga
     7321 acggaacact aaacatttca ggcaacggca atgtgaagtg cgatgcatct gctacagcga
     7381 aagacgatgg ttatcgcatg gtaattgaag cccgaggata cgggacagta aatattcatg
     7441 gtggttctta ctataacacc cagaaactga acacccagat agacctgatt tatgcaagag
     7501 agaatgggaa aatcaatatc tatggaggaa catttgaatc cggcaaatat ggtacaccca
     7561 acaacgacac ggatggcaga tactgggtac tgaacttaaa gaatacagac aagaacactg
     7621 ccagcatcca ggtgtccggt ggaacgttca tcaatttcaa cccggcaaat ccgaatatgg
     7681 acgacaatga gtcctatttg gtaacaggct acgaggttac ccgtgacggc agtgtatata
     7741 cagcagccca caaagtcggt gatgggagga aagaatatat tgttggccaa acaagtcagg
     7801 agaaccgata agccaaattc taagaaagga agcaatatat cctcgcaaac caaacgaaga
     7861 gatatcggaa tcgccttatt actatctttt agatgcggcg gacagcggat tttcttttat
     7921 agatctgcgt cctccgcgtc taaagaatga caacaagaca gttgaaaaat ctctcaaatc
     7981 ttcctcattc acacaaacat tcattatttt tctgagtagc ccaaagtatc atgaataaca
     8041 actaacaatc aaaacatatg agaatacaga tattggatta tcaagtagga ccgcacacct
     8101 ttcgcatggt gaaaccttcc gacttcaata tattcaaggc gctgccttca ctgattccgt
     8161 tcatcacgac aatagacacg acgcaaaaag taatctttga aacagagata gacgatgacg
     8221 aaacaacgac aaaacgaacc atagcgaaaa ctcccgatga tatatgtttc aactgggaag
     8281 atgccgattg catcattcgc cctttgcccc acagctcaca ccttgtatcc atcaccccac
     8341 ggaaaagcgg gaaaaactat tggatggagt gcaacgataa cttcaggcaa tgcttcatcc
     8401 acctaccggc ctgcaggaca gaaacaccgg ctccggaaaa cgaaacgaac ttcgtactga
     8461 acaacttctt gatgatgctc tatgccttca atgccgcccg ccaccataca ctgctgatgc
     8521 atgcctcggt tgtcgctact gaaacaggca aaggctacct cttcttaggg aaaagcggca
     8581 cgggcaaaag tacgcacacc gggctctggc tgcaacagtt ctcggactgc catctactga
     8641 acgatgacaa tccgatagta catgtggaca gcctcggcaa gcaagccact gttttcggtt
     8701 ctccgtggag cggaaagaca ccttgctatc ggaaagaatc catgaccgta ggcgccttcg
     8761 tccgcttgga acaagcaccg cagaatgaaa tagagcaaga gagagcagca catgctttcg
     8821 ccaccctcct cccctcctgc tcttgcctaa agcagaacaa ggaaatctat aacgccattg
     8881 tcgccactgt gacggaactt gccacgctgg cacccgtcta tcatctgaaa tgcctacccg
     8941 accgtgaagc gacggaactt tgcagaaaga cggtagaagg ataagttatg aatgatgaac
     9001 tgaacagccg atgaagaaaa gcattcccaa cgagatattg cttcccgaag tggcgcgtct
     9061 catcaaagag ggacatacag taaccatcac cgtgcggggc aacagcatga atcctttctt
     9121 agtggaccgc cgtgaccggg tgacactggg cgatttcacc acagaacagc tgcaaccggg
     9181 cgtcaccgta ctggcacgcg acctgacgga acgcatcgtc tttcaccgca tcatccgtcg
     9241 gaacggagac atactcatcc tgcaaggcga cggcaacctc gcccagaccg aagaaaccga
     9301 catcggacgg gtaatgggcg tcatgaccga agccatgcga aaagacaaac ggtacaccgc
     9361 cgacggcaaa gtctggaagc tctactccta ctggtggatg aagctaaacc ccgctcgccg
     9421 ctggctgctc gccctgttca gaagaatata aaacaaaata accatgaaaa tcaaacaagg
     9481 atttatcctg caccggatag gcgatgacta catcatcatg caagacggct cgtcgaacgt
     9541 ggacttcagc aaagtcatca gcctgaacca aacttccgcc atgctttggc aagagataga
     9601 aaacaaagag ttcgatacag acagcgtgac agaagccctg accagccgct atgatgtaga
     9661 taacgaatcg gcccgtcgcg atgcgcagaa gtttatcgac tcccttgacc gcgaaggaat
     9721 catagaataa ggacggatat gcaacacgct ttcttttcat tggtacgctc cggcctgtgg
     9781 ggcactccgg cagaccgaca actcttccgg tcggtctcgc cggacgactg ggaaaccgtg
     9841 taccgcatgg caaactcaca agccctgctt gcactgactt ttgacggcat aagcagtctg
     9901 ccggccgaac tgcgccctcc acgcgtcctc tatctgaaat gggctgcccg gactgcacag
     9961 atagaacaag ccaacaaacg cctcaaccag cttctgcccg aactcaatac cctttaccgg
    10021 gaagccgggc tgcatcccgt actgctgaaa gggcaaggca tcggcaccaa ctaccgcact
    10081 cccttgcacc ggcaatgcgg agacatcgac atctatttag gaaaacaagg gcaacccata
    10141 gccaaccgcc tcctgctgca acaaggcgcc atagtcgagg gagaagcgtc cgacaagcat
    10201 gctagctaca gtttgaaagg agtacacatc gagaaccacc gcatcatcct ccggctgaac
    10261 agtccgcttg ccaaccggta ctttcagcag attatcagaa aatggtaccc gcaggaaaca
    10321 gactatgccc tattctccga aaccgggaaa gaggactcga aggccgtcag tatcgccata
    10381 cctccggcca ccttcaatgc actttatatc ttcctgcatg cctttgtaca tttcctgaac
    10441 agcggaatcg gcctgcgcca gctatgcgac tggacttgtc tgcttgccaa tcgccacaaa
    10501 gaaatagatg ccaccaccct gcttcgccag ttgcaggacc tcggactatt gcatgccgca
    10561 caagcattcg gctacattgc cgtcacccga ctgggattgc ccgccaaccg gcttcctttc
    10621 cccttggaag gcaccaagca gataggagaa caattattgg aagacatcct gtctaccggt
    10681 aacttcgggc aacatgataa ccgcatcaag ccacgcccca aaggatattg ggcaggaaag
    10741 tggtacacct tctgccgcgc cacccgacgc tgcaacgaac tgcgtcaatt tgcaccgtac
    10801 gaagcactct ggtatcccgt gactctgata gggggaacga tagctataca aataaaccga
    10861 tcaaaaggag taaaagacaa gaaagcaagg acaaagaaat aaaagaaccc ggaaaataaa
    10921 aggaatgaaa aagcaacaga aggacaaaaa agtgaaaaag gacagacgtg aaaaacttag
    10981 gtatattcga gaggtatctg ccgaacaacg cggacgtatc ctgctaagtt gcctcaccgg
    11041 cattctgggc gtggcctttg ccctagcctt tatctatgca accaaacggg tgatagacac
    11101 cgctaccgga ataacagacg acaacctgac gcatatcgcc gttctcaccg ttgtcctgct
    11161 gactgcccaa ttactgtgcg gagctgctga cacttggata agtacccgta tgcagataga
    11221 gacgggcaac gcccttcgcc accgcctctt ctcgcgctta ctgcaaagcc gctggaacga
    11281 attggagcgt ttccataccg gagacgtagt gaaccgggta gaacaagaca ccaccgccat
    11341 cgtcacattg ctcacctctt ctgtcccggc attcatcgtc acgagtatac aactgctggc
    11401 agcctttcta ttcttctact ttttagaccc ttcactgcca tggctgattg ttgccatcct
    11461 gcccgtcttt ctatcaggca gccgtttcta tatgcgacga atgaaacgct atacacatga
    11521 tattcggaac agtgacggtc gcatccagtc cgtcatacaa gagagcctgc aacatcgcat
    11581 agtgattaaa acattggaac aaggcgaacg gcatctggac aaactcgatg acttgcaaga
    11641 catgctccac agccaagtca tgggacgtac ccgtttctcg ctttctgccc acatgttagt
    11701 ggcccttgcc ttttccggcg gatacctcac ggcttttctt tggggagccg ttcacctcag
    11761 cgcaggctgt atcaccttcg gaacgatgac cgcctttttg caattggtag gaaaagtcca
    11821 gcgtcccgtg ttcgacctct cacgcctgat accttccgta gtcaatgccc ttaccgccat
    11881 agaccggcta ttggaattgg aaagactgcc ggcagaagcg gatggtgaca gcatattcct
    11941 cgcctctacc ccggaactgg aactgaaaga cgtgactttt cgctacactc ccgatgaccg
    12001 tccggtattc agccgccctc actgaccccg ccgttcaggc gtttatgcgc aaggtcacca
    12061 tgcacgtggc cccggagtac tccgagaagc ggaaaaaaga catgaacacc tggtacgccc
    12121 gggtggagat caccgcccgg ggccagacct ttgtggagga gaccgacttc tcctggggca
    12181 gcaacgtgga cggctaccgc ctcacggagg aggagcagaa ggcccagttc cgaacctgtg
    12241 ccgccatcgt gctccccgat gacaagatcg agcgggccat cggcctaatc ctccacctgg
    12301 aggaccagcc ctctttggag gagctgatga gctgcctgtc cctgtgacca acaaaagaag
    12361 aaaggatggt tcccatgccg gaatacgcac cccccgtagg catcgacgcg gcctgcacca
    12421 accagctgga gggaccctat gccccgccga aggggattga cctcctgtgt gaaaatgtgg
    12481 tcaacaccac ctacgaccag ctcagtgaag acaacgtacg tattttcaag gatcgcctgc
    12541 tggacatgac gggctgcatc ttcggcggcg cgattgtgcc cgaggatcag ttcctggccg
    12601 atctcctgcg ccgctggggc ggcattgagg aggcccccct gtttgcccgg aaggggaggc
    12661 tgcccatgcc cagtgccgtc atgctcaaca gcatcaccgc ccgggccaac gactttggca
    12721 atatgttctt ccacgtgctg ggggatcgga tcgcctccca ctgcggcgag actctcatcc
    12781 ccatggggct gaccctggcg gatgtgtatc ccaccagcgg cagggagttt atcgccaaca
    12841 acatcgccgc ggaggatctc accgcccgca tcctctacac cctgcccatg cgctggccca
    12901 ccgatatgct catggtgtcc agcgcggcgg cggccctggc ctcccggtac tacaagctgg
    12961 acgcggccaa aaccaaggtg gcactcacct atgcggccac caacgccacc gaccccggca
    13021 actcctacta tgactactgc caggagttca aataccacaa cggggccagt gcccagatgg
    13081 gcatcatggc ctgtgagctg gcctgcggcg gctggcaggg gttcgccgac ccctatttcg
    13141 gccactggtc gctggtgacc atgcaggtga aggacggcaa gcccctgccc gccctctacg
    13201 agaaagcgtt tgaggggctg ggccaggtgt ggtacaccga ggagagcttc aaacggggtc
    13261 ccggcggtat ccccaccact gccgccgcta agtgcggggc tggggtgcgg cagaagatcc
    13321 tggatgaccg ggggacgctg aacccggcgg atatcaaact ggttcgggtg ttccgctcca
    13381 gtagtatgcg ctttaactac tactccaatc cctttaccag gcggaaccac accaacgccc
    13441 tgttctcctt ccagtttgcc gcctgctgcg ccctgctcca cggggcggta aaggtggagc
    13501 tggtgcagac ccctgccatc caggccgaca cgtacctggt ggagctggcg gagcactcca
    13561 ccatggaggt gttcgaccgc gaggccggaa ggagcatgat gaaggtgatc gtggagatga
    13621 aggacggcgc ggtgtacgag gaccttcagg attacggcgg ttccatgcat gactacccca
    13681 gccgggagtt cctgctgcaa aagttctggg atcagttcaa tgcctacggc aaactgccca
    13741 agtcggtggg ggagaagatc gtggagctgg cggacagaat cgaaaccctc cccgatatgc
    13801 gggaatacac ccagctgctg accttaacgt aaaggagcga tacgatgaaa gaaacctata
    13861 cagaagcccc ccagcccatc gaggtttacg acaaatgcga cgtactggtg gtaggcagcg
    13921 gggcggcggg ccactccgcc gccatcgccg ccgcccgggc gggctgnnnn nnnnnnnnnn
    13981 nnnnnnnnnn nnnctccggc ggcgacgtca ccgggggcta tgtgatcatg gtgcccaacc
    14041 tgagctggta tgacaagtcc tttgtccggg gcctccagga ggagtggttt acccggctgg
    14101 cccctatccc cggcgcggtg cgcggccccg ccctgaagga catcggcagc caagacccgg
    14161 tgctgattga cgcctggcag tccatccacg actgcgtgag ccggggcggc ttcgaggggg
    14221 ccaagccctc ctgcctggtg cgggcggtgt actacgagac caaccagcgc aagatcgag
//
