LOCUS       c00047_gnlPro..        16996 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MMHKJJEH_47.
ACCESSION   c00047_gnlPro..
VERSION     c00047_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 05:35:21
            Original ID  :: gnl|Prokka|MMHKJJEH_47
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16996
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16996
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[697:6996]"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /neighbourhood="10000"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      698..6996
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /neighbourhood="10000"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protocluster_number="1"
     cand_cluster    1..16996
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /kind="single"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16996
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /region_number="1"
                     /rules="(minimum(3, [Amidohydro_1, Amidohydro_3, Arginase,
                     FGase, Urocanase]) and Lyase_aromatic and Urocanase_C)"
                     /tool="gutsmash"
     CDS             complement(2..292)
                     /locus_tag="ctg47_1"
                     /transl_table=11
                     /translation="LCNRILSRHFLMDISIRQLRNSNEQMFKSIVESYWPRLHKFAQIY
                     VLDREVAKEIVQDTFLVLWKQREKLDKETCLITYLMVICRNKCFNYLKGLQL"
     CDS             complement(698..2188)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Lyase_aromatic"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_2"
                     /sec_met_domain="Lyase_aromatic (E-value: 6e-181, bitscore:
                     592.3, seeds: 479, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNVYYVGSEPLTFDSIELILTQNMKLELSQEVRERIQRCRDYLD
                     RKIEQQDGPLYGITTGFGSLCNKNISPDELSTLQENLVKSHACSVGDEVSPVIVRLMML
                     LKAHALSLGHSGVQVITVQRILDFFNNDVLPIVYDRGSLGASGDLAPLANLFLPLIGVG
                     DVYYKGKKREAISVLDEFAWKPVRLKSKEGLALLNGTQFMSANGVFALMRAFRLSQKAD
                     TIAALSLEAFDGRIDPFMDCIQQMRPHPGQIETGAAFRRLLEGSELINRKKEHVQDPYS
                     FRCIPQVHGATKDAINYVSGVLLTEINSVTDNPTIFPEEDKIISGGNFHGQPLAISFDF
                     LAIALAELGNISERRVAQLIMGLRGLPEFLVANPGLNSGFMIPQYAAASMVSQNKMYCY
                     AASSDSIVSSNGQEDHVSMGANAATKLFKVMDNLDHILAIELMNAAQGMEFRRPARTSP
                     VLEKFLRDFRKEVPFIEDDIVMYTEIHRTVAFLRRYPL"
     CDS             complement(2190..2840)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTCD_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg47_3"
                     /sec_met_domain="FTCD_C (E-value: 1.4e-68, bitscore: 220.4,
                     seeds: 242, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LFNTLNINTMLVDLTIKEFLAETASNAPVPGGGSISALNGAIATA
                     LTEMVANLTIGKKKYADVEGQMKTIATEAALIRERLIRDIDRDSEAYDRVFAAFKLPKE
                     TEEQIAERARAIEDATKEAAIVPMQVAEEIASVMETVIYVAHKGNRNAVTDACVAMMTA
                     RTCVLGALLNVRINLASIKDEAFVKQMKVKADHLESEAIRIETKLLDWVKTIV"
     CDS             complement(2856..4085)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Amidohydro_3"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Amidohydro_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_4"
                     /sec_met_domain="Amidohydro_1 (E-value: 3.1e-23, bitscore:
                     72.8, seeds: 57, tool: rule-based-clusters)"
                     /sec_met_domain="Amidohydro_3 (E-value: 5.7e-10, bitscore:
                     29.4, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGDKLLIRNASQVVTCSGFEAKRGTAMSDLHIIEDGAVVVSEGV
                     ITHVGPTKEIVRQVDPDEYLEIDASGRALLPGFVDSHTHFIFGGYREEEFXXXXXXERG
                     GGIVNTVNATRERDFEQLWSIGYERLDEMLDMGVTTVEGKSGYGLDFETELMQLRVMAD
                     LNEEHPVDVVSTYLGAHAVPPEYTHQTDDYITYMIEQVLPELRLERTVTFCDVFCEQGV
                     FSVKQSERLLRAARSQRFKLKMHADEIVSIGGTELAARLKVVSADHLLHASDEGIQRLA
                     RSGVIATLLPLTAFSLNEPYARGREMIDAGCAVALATDYNPGSCFSCSIPMLFALACIQ
                     MKLTPEEAVTALTINGAAALGRANKIGSIDVGKKADLILLKYPSYKFLPYNVGMNIVDT
                     VIKDGIIYMI"
     CDS             complement(4089..4994)
                     /locus_tag="ctg47_5"
                     /transl_table=11
                     /translation="MSSWNRIMECVPNFSEGRDLGKIEKIIEPFRARQGVKLLDYSNDE
                     DHNRLVVTVVGEPEALKAALLEAVGQAVALIDLNRHSGQHPRMGAVDVIPFIPIKGCTM
                     DEAIALSKEVGEQIATLYQVPVFLYEKSATAPHRENLAAVRKGEFEGMAEKIKLAEWQP
                     DFGPAERHPTAGTVAVGARMPLVAYNVNLGTADLNIASDIARKIRFIGGGLRYCKAMGV
                     ELKERGIVQVSINMTDYTRTALYRAFELVKIEARRYGVAVVGSEIIGLVPMEALIDTAS
                     FYLGLENFSMNQVLEARIME"
     CDS             complement(4999..6996)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Urocanase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Urocanase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Urocanase_N"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg47_6"
                     /sec_met_domain="Urocanase (E-value: 1e-82, bitscore:
                     267.1, seeds: 148, tool: rule-based-clusters)"
                     /sec_met_domain="Urocanase_C (E-value: 5.6e-86, bitscore:
                     277.2, seeds: 88, tool: rule-based-clusters)"
                     /sec_met_domain="Urocanase_N (E-value: 3.1e-53, bitscore:
                     169.1, seeds: 71, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIHLGSQLPAYPSFVAGIRRAPDRGYSLTSAQTETALKNALRYI
                     PKELHETLAPEFMEELRTRGRIYGYRYRPEGDLKARPIDDYRGNCLEGKAFQVMIDNNL
                     CFDIALYPYELATYGETGQVCQNWMQYRLIKQYLEIMTQEQTLVIESGHPLGLFRSRPD
                     APRVIITNSMMVGMFDNQKDWHVAAQMGVANYGQMTAGGWMYIGPQGIVHGTFNTLLNA
                     GRLKLGIPQDKDLRGHLFVSSGLGGMSGAQPKAAVIAGAACIVAEVDRSRIETRHSQGW
                     VQLVTDNEAEAFRLATDACRAKEPLSVAYHGNIVDLLEYAASESIPIDLLSDQTSCHAV
                     YEGGYCPAGISFEERTRLLSEDQETFCALVDRSLRRHYEVIKRLVEGGAYFFDYGNSFL
                     KAIYDAGVKDISRNGIDEKDGFIWPSYVEDIMGPELFDYGYGPFRWVCLSGKKEDLVKT
                     DHAAMDCIDPDRRGQDRDNYNWIRDAEKNNLVVGTQARILYQDAEGRLKIALRFNQMVR
                     DGEIGPVMLGRDHHDVSGTDSPFRETSNIYDGSNVMADMAVQCFAGNAARGMSLVALHN
                     GGGVGIGKAVNGGFGMVLDGSNRVDEILRSAMLWDVMGGVARRAWARNRHALETSETFN
                     KNNENQYHITLPYIPEEELIRKTIKTSLNT"
     CDS             complement(7021..7143)
                     /locus_tag="ctg47_7"
                     /transl_table=11
                     /translation="LRDGLFSCLQYASKHIAEIVRLHGNIYLVGHLQLFYSDKL"
     CDS             complement(7181..10204)
                     /locus_tag="ctg47_8"
                     /transl_table=11
                     /translation="MQNKGFVRVFAVLLTLVCLFYLSFSFVTRYYNNKAAEYAGGDPSK
                     ESLYLDSLSTQKVWLGYTLKQCREMEISLGLDLKGGMNVVLELNVADVIRSLSNNNQDE
                     NFNKALDLAYARQATSQKDFIDLFAEEYKNLDNGARLSAIFSTFELKDKITPQSTDAQV
                     VSVLKDELKSAIDNSFNVLRTRIDRFGVVSPNIQRLETAGRILVELPGVKEPERVRKLL
                     QGSANLEFWETYQLPEVYQQLVAADNVLATVLKEHNDEAAVTETETVSADGTETTATET
                     VTDNAAATSEADSLLQQIAQDKPEAQANQSMEEFAKQHPLFALLQINQYNGQLGRGAAV
                     GVANVRDIPKINEYLAMKQVKDVLPRNLSLKWGVKAIDEKEQFFELYAIKVTNRDGTPA
                     LGGDVVTDANADFVQQAGRSEQQVSMAMNAEGAKAWARLTKENIGKAIAIVLDDMVYSA
                     PNVNDEITGGRSQITGHFTPEEAKDLANVLKSGKMAASVHIVQEDVVGPSLGQEAISSG
                     VISFALALILLMIYMCAFYGIIPGLIADGALVLNIFFTMGILASFQAVLTLPGIAGMVL
                     TLGMAVDANVLIYERTKEELRAGKSLSKAIADGYSNAFSAIFDSNLTSIITGVVLFYFG
                     TGPIRGFATTMIIGLFASFLTAVFLTRMVYEALLAKDKLKNVTFVTSITKDLLTNPKIN
                     FLGARKTGYLIPAGIVLLGAISMMTIGLNNGIDFTGGRNYIVRFAQDVKTDEVRNMLDE
                     KLDGAVSVITIGTPDQVRVSTNYKIDDADPAVDQEIESLLFEGVKPLLPEGTTLDQFTT
                     TYIQSSQKVGPSMADDIKNSAIMAVIFAMFCMAAYILLRFRDWSFSVGAFASVAVTTLC
                     IISFYTLLWKVLPFSMEVDQTFIAAILTIIGYSINDTVVVFDRIRETIGLYPKRDRYQV
                     INDALNSTLSRTFNTSLTTLVVVLCIFILGGSTIRSFTFAILLGIIVGTYSTLFVATPI
                     AYEIQKRKINKKAAEAAK"
     CDS             10374..11411
                     /locus_tag="ctg47_9"
                     /transl_table=11
                     /translation="MKQLLLFLLFIPSLLMAQEDQKYLAGAIPEEGGKVVFTKEINMPS
                     LSKGQIYDIMYQWAEKFFSEEGRRLVYSDKDKGDIAAVGEEYLVFQSTALSLDRTLMDY
                     RVTIECEDNAAKIKLAGIRYEYNVSYQREPEKYTAEEWITDKYALNKKKDKLNRGNGKF
                     RRKTVDFAENMFQSADAAFGIQPAGTVTPAYALTPATPVQQQQQTVRPAAPAQQIAQAP
                     VGNNTEVCQGLSAFEPDKIPSTLLNMLPDSRMQVTPADKENLIERYATWKEMGKMFGKN
                     IASISISPESEVYKAVKDNDIYTITFTKKDDTETWFMIQCVKQGESSEGQQKIVIGEIL
                     NVWIR"
     CDS             11399..11971
                     /locus_tag="ctg47_10"
                     /transl_table=11
                     /translation="MDQINTKMIKKTILLLLLICPVLAMAQGHKGSVESCAPMKEGKVC
                     YSDEVDVEGVKKGELFKAIDKWAKKNYGKDVFLSSVNSSKSKGTIFINSKVELLLNDTD
                     KTIVKYKMRIYCHDEKYNVELTDISYQYDPNNEKKYKTYPAENVIANNGKSNTIALIKD
                     PLLFCNATFFFAENLFADVFSAADNDE"
     CDS             complement(12030..13103)
                     /locus_tag="ctg47_11"
                     /transl_table=11
                     /translation="LFVLANVLIVVLFVISAYSDRVSPDTILSFSYLGLVFPILCVLNL
                     CFILYWLFLWEWRFLLIGLCSILICWGPVKKYFPYHSRTKDIPKENVLKVLTYNVMAFA
                     YLNHTAESPNKILEYIAGSGADIVCLQEYAVSKSDKYLTSSKVYKALDMYPYRSVIPIN
                     KTSYADYGIAVFSKYPISNSRKIKYKSDSNASSIHELNVNGKKLTLINNHLESFKLTME
                     DRSRYTAFIKNIGTDTFDGIKGALEQKLGPAFKIRARQADAVAEEISKAKGDYILVCGD
                     FNDTPISYAHRTVQGPLVDSFAESGQGMGITYNQNMFWFRIDNILHSKNMKSMNCTIDK
                     VRYSDHYPLWCYLSLEE"
     CDS             13778..14056
                     /locus_tag="ctg47_12"
                     /transl_table=11
                     /translation="MKEVEMGEHISNDRPRPVHQQLRRRRHLQILQKGYSGDIKKEKYH
                     PHQPDQDEKPYINIYELCQYISCPERILQISKNTFHCLHLSFSSSEP"
     CDS             complement(14001..14711)
                     /locus_tag="ctg47_13"
                     /transl_table=11
                     /translation="MMNQNGSGFLNSIPPVTKNLIIINLLFWVASLVLPKVGIDLVQLL
                     GLHFPGVKDFYPFQFVTYMFMHDTHSFAHVFFNMFGVYMFGRVLENVWGPKRFLTFYLV
                     TGIGAGIVQELVWAYSVQSFASANGLTLFELVRMDPSLNMMITIGASGSVFGILLAFAM
                     LFPNVPLFLMFIPIPIKAKYFVVFYGLAELFMGVSSFGGDTVAHFAHLGGMLFGFFMVR
                     YWKKKDADNGKYFY"
     CDS             14896..15168
                     /locus_tag="ctg47_14"
                     /transl_table=11
                     /translation="MNKTEFITAVAEKSGLSKADAKKAVDAFVETVSDEMKAGGKIALL
                     GFGSFSVTEKAARKGVNPKTKQPIEIAARKAIKFKPGAELNDKVQ"
     CDS             complement(15699..16664)
                     /locus_tag="ctg47_15"
                     /transl_table=11
                     /translation="MKLKSLLRHIDMWFVLIGSLIMTSCDSFNEDLPECRLFVKFKYDY
                     NMEFADAFHSQVDKVELYVFDKNGKFLFKQAEEGSMLGTGSYLMEVKLPVGQYQFMAWA
                     GAHDSYDITSLQAGVSSIADLKLQLKREETLIIDKELEPLWYGEINNVDFTGTTDQTEV
                     INLIKDTNKVRFVFQGSNEDSWGVDVNAYTYEIIESNGYLAHDNSLLGDDNLSFRPYHI
                     EQKNLAAGIVELNTMRFLANRNARFVVTEKATGKKVFNINLTDFLVMTKIEGHNMSAQE
                     YLDRESEYKIVFFFADNDPWLVLQININGWTWYFQHEGGL"
ORIGIN
        1 ccaattgtaa acctttcaaa taattaaaac atttattccg gcatatcacc attaaataag
       61 ttatcagaca ggtctctttg tccaattttt cccgttgttt ccacaaaaca aggaaagtat
      121 cctgcacaat ctctttggcc acctctctat ccaatacata aatctgggcg aacttatgta
      181 aacggggcca ataagattct acaatacttt taaacatttg ctcattacta tttcttaatt
      241 gccgtatgct tatatccatc agaaagtgtc tacttagaat tctattacac aatcaaagcc
      301 aaaaatataa atacaaacct ctgtaacagt ggattttctt tatatgaaaa tattgaatga
      361 ctagaaaaaa cgatcgtttt ttctagtcac gattttagct gtttttgagt aaaagaagac
      421 acnnnnnnnn nntttatgag cgtatttcta agtataaaat gcaatgaatc agtcgttttt
      481 tctttttata aacatctata aataaaaaaa tgtgagtacc ttcgcggtga ctaaaaaaaa
      541 cgatcgtttt ttttagtcag ttaaattctc ataaaaaatt agagccgaag ctttatattc
      601 aaaagcttcg gctctacaat caggccatat ccacacggat aattcagaaa caaaggtctc
      661 tcaaaacata tagctgaact atctacgatc agcgtaacta caacggatac ctccgcagga
      721 aagccaccgt acgatggatc tccgtgtaca ttacaatatc atcctctatg aaagggacct
      781 ccttccggaa gtctctcagg aatttttcaa ggacaggtga agtcctggcc ggacggcgga
      841 actccattcc ttgtgccgca ttcattaatt caatcgccag gatatgatcg agattatcca
      901 ttaccttgaa tagtttggtt gcagcattgg ctcccatgct gacatgatct tcctgaccat
      961 tgctggatac gatcgaatcg ctgctggcgg cataacaata catcttattc tggctgacca
     1021 tgcttgcggc ggcatattgc gggatcataa aaccggagtt caacccggga ttggcaacaa
     1081 gaaattccgg taaaccgcga agtcccatga tcaattgggc gacacggcgt tcggatatat
     1141 ttcctaattc agccaaagcg atggccagaa agtcgaaaga gatagccagc ggctgaccat
     1201 ggaaattacc acccgagatg atcttgtctt cttccgggaa gatggtcgga ttatccgtca
     1261 ccgaattaat ctccgtgagc aatacgccgg aaacgtaatt gatcgcatcc tttgtcgctc
     1321 cgtgaacctg cgggatgcaa cggaaagaat aagggtcctg cacatgctcc tttttccggt
     1381 tgatcagttc gcttccctcc aacaaccggc ggaaagctgc tcccgtttca atctgtcccg
     1441 gatgaggacg catctgctgg atacaatcca taaaaggatc gatacgaccg tcgaaggctt
     1501 ccaaagacaa ggccgctatc gtatccgcct tttgggaaag acgaaaagca cgcatcaggg
     1561 caaaaacgcc atttgcactc ataaactgtg ttccgttcag taaagccagt ccctctttac
     1621 ttttcaggcg tacgggcttc caggcaaact catccaatac gctgatcgct tcgcgcttct
     1681 ttcctttata atagacatct cccactccga tcagcggcag gaagagattc gccaacggag
     1741 ccagatcgcc ggaagctccc agggaccccc ggtcataaac gatcggcagg acatcattat
     1801 tgaagaaatc gaggatacgt tgtacggtaa taacctgtac accgctatgg cccaaagaca
     1861 aagcgtgtgc tttcagcagc atcatcaacc ggacaatgac gggactcacc tcgtcaccga
     1921 cactacaggc atgacttttc accaggtttt cctgtaaggt actcagttcg tcgggcgaga
     1981 tatttttatt gcataacgag ccgaagccgg ttgtaatgcc ataaagcgga ccatcctgtt
     2041 gttcgatttt ccggtccagg tagtcgcggc aacgctggat gcgttcgcgc acttcctggc
     2101 ttaactcgag cttcatgttc tgagtcagga tcaactcaat gctgtcgaat gtcagcggtt
     2161 cagaacctac ataatagaca ttgctcatgt tatactattg ttttaaccca atccagtaac
     2221 ttcgtttcaa tacggatcgc ttccgattcc agatggtcgg ctttcacttt catctgcttc
     2281 acaaaagctt cgtctttgat ggaagccagg ttgatacgta cgttcagtag ggctcccagg
     2341 acacaggtac gggcagtcat catggcaaca caagcatcgg taacagcatt ccggtttcct
     2401 ttatgtgcta cataaatgac ggtttccatc acagacgcga tttcttcggc aacctgcata
     2461 ggaacaatag ccgcctcttt cgtggcatct tcaatggccc gggcacgttc ggcgatctgc
     2521 tcttccgttt ctttcggaag tttaaaggcg gcaaacacac gatcgtaggc ttcactgtca
     2581 cggtcgatgt cgcggatcag gcgctcacgg atcagggccg cttccgtagc gatcgttttc
     2641 atctgccctt ccacatcggc atacttcttt ttcccgatgg tcaggttggc gaccatctct
     2701 gtcaatgcag tagcgatagc accgtttaag gctgaaatac ttccgccgcc cggaaccggt
     2761 gcgttactgg ctgtttccgc cagaaattct ttaattgtca agtctacaag catggtattt
     2821 atatttaagg tattaaacaa tgaataaact gtttctcaaa tcatataaat gattccgtcc
     2881 ttaatcaccg tatccacgat attcattccc acattataag gaaggaattt ataggacgga
     2941 tatttcagca ggatcaggtc ggccttcttt ccaacatcta tgctgccgat cttattggca
     3001 cgccccaaag ccgcagctcc gttaatcgtc aaagcggtaa ccgcttcttc cggagtcagt
     3061 ttcatctgga tacacgccaa agcgaaaagc atcgggatag aacaggaaaa acaactgccg
     3121 ggattataat cggtagccag cgcaactgca caaccggcgt caatcatctc acgaccacgg
     3181 gcataaggtt cgttcaacga aaaggcggtg agcggaagca aggtggcaat caccccgctg
     3241 cgtgccaacc gttggatgcc ttcatccgaa gcgtgcagca aatgatcggc actgacaacc
     3301 ttcagacggg ccgccagttc cgtacctcca atagatacga tctcatcggc atgcatcttc
     3361 aacttaaacc gctggcttcg ggcggcacgt aacaaacgtt cgctctgttt taccgagaat
     3421 actccctgtt cacaaaaaac atcacagaaa gtaaccgttc tctccagacg aagttccggc
     3481 aagacctgtt cgatcatata agtaatgtaa tcatccgtct gatgagtata ttcaggggga
     3541 acggcatgag ctcccaaata agtagacacg acatcgaccg gatgttcctc gttgaggtct
     3601 gccattacac gcaactgcat cagttcggtt tcgaaatcaa gaccatatcc actcttccct
     3661 tccaccgtcg ttacgcccat gtccaacatt tcgtcgagcc gttcataacc gatactccac
     3721 agttgctcga aatcacgttc acgggtggca ttgaccgtat tgactatacc gccgccacgc
     3781 tcnnnnnnnn nnnnnnnnnn aaactcttct tcacgataac caccgaaaat aaaatgggta
     3841 tgactatcca caaacccggg aagcaatgcc cttccactgg catcgatttc cagatattcg
     3901 tccggatcta cctgacgtac tatttctttt gtcggaccga catgcgttat aacaccttcg
     3961 gaaacaacca ctgctccatc ttctataata tggagatcag acattgccgt ccctcttttt
     4021 gcttcaaaac cggaacaggt tacaacttgc gatgcgttcc ttatcagtaa tttatctcct
     4081 ttcatgtttt attccattat tctagcttct aacacctggt tcatggaaaa gttttccaac
     4141 cctaaataga aagaagctgt atcaatcaat gcttccatcg gaaccaatcc gataatctca
     4201 ctacctacaa ccgcaacacc ataacggcga gcctctatct tcaccagttc aaaagcgcgg
     4261 tacaaggccg tacgagtata gtcggtcata ttaatcgaga cctgcacgat accccgttct
     4321 ttcagttcga ctcccattgc tttacaataa cgaagaccgc cgccgataaa acggatctta
     4381 cgggcaatgt cgctggcaat attcaaatcg gccgtaccca gattgacatt ataagcaaca
     4441 agcggcatgc gggcaccaac ggcaaccgta ccggctgtcg gatggcgctc cgccggtccg
     4501 aagtccggct gccattctgc aagtttaatc ttctcagcca tcccttcgaa ctcacctttc
     4561 ctgactgctg ccagattctc ccggtgaggg gcggttgccg acttctcata taaaaacaca
     4621 gggacctggt ataaggttgc aatctgttca ccaacttctt tggataaagc aatcgcttca
     4681 tccattgtac atcctttgat cgggatgaac gggatcacat cgacagctcc catccgcgga
     4741 tgttgtccgc tatgccggtt caggtctatc aaagcgaccg cctgtcctac agcctccaac
     4801 agggcggctt tcaacgcctc cggttcaccg actacagtaa cgaccaggcg attatgatct
     4861 tcatcattgc tataatccaa cagttttact ccttgcctgg ctctgaacgg ctcaataatc
     4921 ttttctatct tccctaagtc cctaccttca ctaaaattgg ggacacactc cataattcta
     4981 ttccaactac tcataaattc aggtatttaa agaggtcttt attgtttttc gtatcaattc
     5041 ttcctccgga atataaggaa gagtgatatg atactgattc tcattattct tattaaatgt
     5101 ttcacttgtt tccagagcat gccggttacg tgcccaggca cggcgcgcca caccgcccat
     5161 tacatcccat aacatggcag aacgtaatat ttcatcgaca cggttacttc cgtcgagaac
     5221 cataccgaat cctccgttta ccgctttacc gataccgaca ccaccaccgt tatgaagggc
     5281 taccagactc attccgcggg ctgcatttcc ggcaaaacac tgtacagcca tatcggccat
     5341 gacgttacta ccgtcgtaga tattggacgt ctcccggaaa ggcgagtctg tcccgctgac
     5401 atcatggtgg tcgcgtccca gcatcaccgg cccgatctct ccgtcacgga ccatctgatt
     5461 gaaacgaagt gcaatcttca gtctgccttc ggcatcctga taaaggatac gggcctgtgt
     5521 acctactacc agattgttct tttcggcatc gcgtatccag ttgtagttat cacggtcctg
     5581 tccccgccgg tccggatcga tacaatccat ggcggcatgg tcggttttga ccaggtcttc
     5641 ttttttcccg ctcagacaaa cccagcggaa aggaccgtag ccgtaatcaa ataattccgg
     5701 tcccattata tcttccacat aagacggcca gataaaacca tctttctcat cgataccatt
     5761 cctggatata tcttttacac cggcatcata aatcgctttc agaaatgaat tgccgtaatc
     5821 gaagaaatag gctccgccct cgaccaaccg ttttatcact tcataatgcc tgcgcaaaga
     5881 acggtccacc agggcacaaa acgtttcctg gtcttccgaa agcaaacgcg tacgttcttc
     5941 gaaagagatt cctgcgggac agtatccacc ctcataaaca gcatgacacg aagtctggtc
     6001 gctcagcaag tcgataggaa tagattccga tgcggcatat tccaacaggt ctacaatatt
     6061 cccatgataa gcaaccgaaa gaggctcttt ggcacggcaa gcatccgtag ccaggcgaaa
     6121 agcctcggcc tcgttatctg taaccaactg gacccatccc tgcgaatggc gtgtttctat
     6181 tcgcgatcga tccacttccg ccacaatgca ggcagcaccg gcaataacag ccgctttcgg
     6241 ttgtgccccg ctcattcctc ctaatccgga cgagacgaaa agatgtcctc gcaagtcctt
     6301 gtcctgcggt atgccgagtt taaggcgacc ggcattcagg agcgtattga aggttccatg
     6361 cacaataccc tgcggtccga tatacatcca ccctccggct gtcatctgac catagttggc
     6421 aacccccatc tgggctgcca catgccagtc cttctgatta tcgaacatac cgaccatcat
     6481 cgaattggtg ataattaccc ggggagcatc cggcctggaa cgaaacagac cgagcggatg
     6541 gcccgattca atcaccaggg tctgctcctg tgtcatgatc tccagatatt gtttgatcaa
     6601 ccggtattgc atccagttct gacagacctg acctgtctct ccatacgtcg ccaactcata
     6661 aggataaagg gcaatgtcga aacagaggtt attgtcaatc attacctgga aagcttttcc
     6721 ttccaggcag tttcctcgat aatcatcaat gggacgtgct ttcagatcac cctccggacg
     6781 ataacgatac ccgtatattc ttccacgggt acgaagctct tccataaatt caggtgctaa
     6841 tgtctcatga agttctttcg gaatgtacct taaggcattt ttcaatgctg tttcagtttg
     6901 tgcagacgta agggaataac cgcgatcggg ggcgcggcgg ataccggcaa caaaagaagg
     6961 atatgccggc aattggctac ctagatgtat atccataact gatgacgttt taaaataaac
     7021 ttacaatttg tcagaataaa acaattgcaa gtggcctaca aggtagatat ttccgtgcaa
     7081 ccggacaatt tcggctatat gtttagaagc atattgtaaa caagaaaaaa ggccatcccg
     7141 caatgagatg gccttttcat tatttcataa aaactgtctg ttacttagca gcttcggcag
     7201 cttttttgtt gatctttctt ttctgtattt cgtatgcaat cggagttgca acgaacagtg
     7261 tagaatatgt acctacgatg atacccagca ggatagcgaa cgtaaagcta cggattgtgc
     7321 taccacccag gataaagata caaagtacta caaccaatgt tgtcaatgat gtattgaatg
     7381 tacgagacaa cgttgagttc aaagcgtcat tgatcacctg gtaacgatcg cgtttcggat
     7441 acagaccgat tgtttcacgg atacggtcga atacaaccac ggtatcattg atagagtaac
     7501 cgataatcgt caggatagcc gcgataaatg tctggtcgac ttccatagag aacggtaaca
     7561 ctttccataa taaagtatag aaagagatga tacacaatgt tgtcactgct actgaggcaa
     7621 atgcacctac tgagaacgac cagtcacgga aacgaagcag gatataagct gccatacaga
     7681 acatcgcgaa gataactgcc atgatagcgc tgttcttgat gtcgtcggcc atactcggtc
     7741 ccactttctg agaactctgg atgtaagttg ttgtaaactg atccaatgtt gttccttccg
     7801 gaagcagcgg tttaacgcct tcgaacaata atgattcgat ttcctggtct acagcaggat
     7861 cggcatcgtc gatcttatag ttggtagaaa cacgaacctg atccggtgta ccgatcgtga
     7921 taacacttac agcaccatcc agtttttcgt ccagcatatt acgaacttca tccgttttta
     7981 catcctgcgc aaaacgaacg atatagttac gtccaccggt gaagtcgata ccgttattca
     8041 aaccgatcgt catcatggag atcgctccca aaagaacgat accggcagga atcagataac
     8101 cagtcttacg ggcacccagg aagttgatct tcggattagt caacaggtct ttcgtgatag
     8161 atgttacaaa tgttacattc ttcagtttat ccttagccaa taatgcttca taaaccatac
     8221 gagtcaggaa gaccgcagta aggaaagaag caaacagacc gataatcatt gtagtagcga
     8281 aaccacggat aggacctgta ccgaagtaga acaatacaac acctgtaatg atagatgtca
     8341 agttggagtc gaagatagca gagaacgcgt tactgtaacc atcggcaata gctttgctca
     8401 acgacttacc ggctcgaagc tcttcttttg tacgttcata gatcaacacg ttagcatcga
     8461 ctgccatacc cagtgtcaac accataccgg cgatacccgg caaagtaagt acagcctgga
     8521 aagaagcaag gatacccatc gtgaagaaga tgttcaatac caatgcaccg tctgcgatca
     8581 gacccgggat aattccgtag aatgcacaca tatagatcat caacagaatc aatgccaaag
     8641 caaaggagat aacacctgag ctgatagctt cctgacccag tgacggaccg acaacgtctt
     8701 cctgtacgat atgtacagaa gcagccatct tacctgattt caatacgtta gctaagtcct
     8761 tcgcttcttc cggagtgaag tgacctgtaa tctgagaacg tcctccggta atttcgtcat
     8821 ttacgtttgg agcggaataa accatatcat ccagaacgat agcgatagct ttaccgatat
     8881 tctcttttgt caaacgagcc catgccttag caccttctgc gttcatggcc atactaacct
     8941 gctgttctga acggccagcc tgctgtacga agtctgcatt agcatcagtt actacgtcac
     9001 cacctaaagc aggcgttccg tcacggttag taaccttgat agcatataat tcgaaaaatt
     9061 gttctttttc gtcgatagcc ttaacacccc atttcaaaga caggttacga ggtaacacgt
     9121 ctttcacctg tttcattgcc aagtattcgt tgatcttagg aatgtctctt acgttagcca
     9181 caccaacggc agcaccacga cctaactggc cgttatactg attgatctgt aacaaggcaa
     9241 acaacggatg ctgttttgca aattcttcca tcgactggtt agcctgagct tccggtttat
     9301 cctgagcgat ctgctgtaac agagaatcag cttcgctagt agcggcagca ttatctgtaa
     9361 cagtttccgt agcagttgtt tcagtaccat cggcagaaac agtttctgtt tcagttacgg
     9421 ctgcttcgtc gttatgttct ttcaaaacag tagccagtac attgtcggca gcaaccaact
     9481 gttggtaaac ttccggcaac tgataagttt cccaaaattc caggtttgca ctgccctgta
     9541 acaatttacg aacacgttcc ggttctttta cacccggaag ttccaccagg atacgtcctg
     9601 ctgtttccaa acgctggatg ttaggagata ccacaccgaa acggtcgata cgggtacgca
     9661 atacgttgaa tgaattatcg atagcactct tcagttcgtc ttttaatact gaaacgacct
     9721 gagcatctgt gctctgcgga gtaattttat ctttcaactc aaatgtactg aaaatagcag
     9781 acaaacgtgc gccattatcc aggttcttgt actcttctgc aaacaagtca ataaagtctt
     9841 tctgactggt tgcctggcga gcataagcta aatccaaagc cttgttgaag ttctcatcct
     9901 ggttattatt tgaaagcgaa cggattacat ctgccacatt caattccaga acgacgttca
     9961 taccgccttt caggtcaagt cctaaactaa tttccatttc acggcattgc ttaagcgtat
    10021 agcccagcca caccttctga gtagataatg agtccaaata aagactctct ttcgacggat
    10081 cccctcccgc atactcagcg gctttattgt tgtaatatct tgttacaaat gagaacgata
    10141 gatagaacaa acatacaagc gtaagtaaca ccgcgaagac ccttacaaat cctttgtttt
    10201 gcatttgaat cttgagttta tgttattaca ttatttattt tcgttttttc acagggtgca
    10261 aatataggct ttttttcttt gtcaaatagt aattagatta attatttgtc actctcttag
    10321 ttaatttcaa gtacaaatat atatctttgc cagtaaaaaa acacagattg accatgaaac
    10381 agctattatt attcctttta tttattcctt ccctgcttat ggcacaggaa gatcaaaagt
    10441 atttagccgg tgctatccct gaggaaggag gcaaagtcgt atttaccaaa gagataaata
    10501 tgccgtcgct ttcaaaaggg cagatttacg atatcatgta ccaatgggcc gaaaagttct
    10561 tcagcgaaga aggacgccga ctggtctatt cagacaagga caaaggcgat attgcagcag
    10621 taggtgaaga atacctggta ttccaaagca cagctttatc attggaccgc acactgatgg
    10681 attaccgcgt aaccatcgaa tgcgaagaca atgcagctaa aattaaactg gccggcatcc
    10741 gctacgaata caatgtatcc tatcagcgtg aacctgaaaa gtacacagca gaagaatgga
    10801 tcacagacaa atatgcactg aacaaaaaga aagataaact gaatcgcggt aacggcaagt
    10861 tccgtcgtaa aacagttgat tttgcggaaa atatgttcca gagtgccgat gccgcattcg
    10921 gtatccagcc ggccggtacg gtaacacctg cttatgccct tacccctgca actccggtgc
    10981 aacagcagca acaaacagtc agaccggcag ctcctgccca gcaaatcgca caggctcccg
    11041 tcggcaacaa tacagaggta tgccagggtt tatccgcttt cgaaccggat aaaatcccgt
    11101 ctaccctatt gaatatgctg ccggatagca gaatgcaggt aacaccggca gataaagaga
    11161 atctgatcga gagatatgcc acctggaaag aaatgggcaa gatgttcgga aagaatatcg
    11221 cttctatttc tatcagcccg gaaagtgaag tctacaaagc agtcaaagat aacgacatct
    11281 acacgatcac tttcaccaaa aaagatgata cggaaacctg gttcatgatt cagtgcgtta
    11341 agcagggcga gtcaagcgaa ggacaacaga aaatcgttat tggagagata cttaacgtat
    11401 ggatcagata aatacaaaga tgataaagaa aacaatatta ctgctattgc tgatatgtcc
    11461 tgtgcttgct atggcacagg gacataaagg cagtgtagag tcgtgtgccc cgatgaaaga
    11521 gggaaaggtt tgctacagcg acgaagtaga cgttgaaggc gtgaagaaag gcgagttgtt
    11581 taaagcgatc gacaaatggg ccaagaagaa ttatgggaaa gatgttttcc tgtcgagtgt
    11641 caattccagc aagtcgaaag gaacgatatt tatcaactca aaggtcgaac tactcttgaa
    11701 cgatacggat aaaacaatcg tcaagtacaa gatgagaatc tattgccacg acgagaaata
    11761 taatgtagag ctgacggata tttcatatca atacgatccg aacaacgaaa agaaatacaa
    11821 aacctatccg gccgaaaacg ttattgcaaa caatgggaaa agcaatacga tcgcattgat
    11881 caaagacccg ttacttttct gtaatgcgac cttctttttt gcagaaaatt tatttgccga
    11941 tgtgtttagt gcagcagata atgacgagta aaaaataaac agactatata tattaatgta
    12001 aggggattcc gccaaggggt tcccttattt tattcttcca ggctcagata gcaccataac
    12061 ggatagtggt cggaataccg taccttatca atagtgcagt tcatggattt catattcttt
    12121 gaatgcaata tattatcgat gcggaaccag aacatattct gattataggt tattcccatc
    12181 ccctgtccgg attcggcaaa cgaatcgact aaaggtccct gtaccgtacg atgtgcatat
    12241 gaaatcggcg tatcattaaa gtcaccgcaa accaggatgt aatcaccttt tgcctttgag
    12301 atttcttctg cgacggcatc tgcctgccgg gcacgtatct taaaagccgg acccagtttt
    12361 tgttcaagcg cacctttaat cccatcgaaa gtatccgtgc cgatattttt tataaaagca
    12421 gtatagcggc tccggtcctc catcgtcagt ttaaaagatt ccaaatgatt attgatcaaa
    12481 gtcagtttct ttccattcac attcaactca tgaatagaag aagcattgct atcgctttta
    12541 tattttatct tccggctgtt cgagatcgga tatttagaaa agactgctat cccataatct
    12601 gcataactag tcttatttat aggaataaca gaacgatacg gatacatatc aagtgcctta
    12661 tataccttcg aagatgtcag gtacttgtcg gatttactca cggcgtactc ctgcaaacag
    12721 acaatatcgg cccccgaacc ggcaatatat tcgagaatct tattaggaga ttccgccgta
    12781 tggttcaggt aagcaaaagc cattacatta taagtcagca ccttcaatac attttctttt
    12841 ggaatatctt tcgtccggct atgataaggg aaatactttt tcaccggtcc ccagcagatc
    12901 aggatagaac ataatccgat cagcaggaaa cgccattccc acaaaaacag ccaatagagg
    12961 ataaaacaaa ggttcaggac acataaaata gggaaaacca atcccagata agaaaaactt
    13021 aggatagtat caggagaaac acgatctgaa taagctgaaa taacaaacag cacgacaatc
    13081 aaaacattgg caagaacgaa caatgatttg aataaaagct tcagtgtttt caatccttca
    13141 ctcatttttt acttgcgtca aataattgcc ttttttcatc ggctgaaaga ctctcatatc
    13201 cggaacgttt caatttatcc agaatagcat caaggtctgc cgattcccgg tgtttacggg
    13261 cattatattc ataatcggtt tctgcacgtt tgtgcgtcac cttcatttta ggttttctct
    13321 ttccgagatt caccacccaa tccaacaggc gattcatcgg tgccgtcagg tctttccctt
    13381 ccttaatccg catggcaaac cagataccga ataatgcacc gccaatatgg gcaatatgcc
    13441 caccggcatt ctcggaagta atagccagca ggtcgatcac aaaagtgaag agtgccagat
    13501 agatcaactt gatccgtcct atcaggaaca gatttatctc cagatctttc cggtagaacg
    13561 atacggcaaa aactattgcc atcaccgaag ccgaagcccc catcagatag cttgaagaag
    13621 ccaccgtctg aaaatacgga aagatattat aagcaagcat aaacagtatt gcaccggcaa
    13681 tacctcccag cagatacaat ccccccaact gccgttcgct gaaaaatgtc agaaacaatc
    13741 caccaaacca gtacaaccaa agcatattaa aaaggatatg aaggaagtcg aaatgggtga
    13801 acatataagt aatgaccgtc cacggccggt acatcagcaa ctccggcgaa gaaggcatct
    13861 gcaaatattg caaaaaggat attccgggga tattaaaaag gagaaatatc acccccatca
    13921 accggatcag gatgaaaagc cctacattaa tatatatgag ctttgccagt atatttcctg
    13981 cccggaacgt attcttcaga ttagtaaaaa tactttccat tgtctgcatc tttctttttc
    14041 cagtagcgaa ccataaagaa gccgaacaac ataccgccta aatgggcgaa gtgtgcgacc
    14101 gtgtctccac caaaactgga aacacccata aatagttcag ccagaccgta aaacacaaca
    14161 aaatatttag ctttaatagg tatcggaata aacatcagga acaacggcac attcgggaac
    14221 agcatggcaa acgccaacag gataccgaac actgaaccgg aagcccctat cgtgatcatc
    14281 atattcaacg agggatccat acgaaccagt tcaaacaacg tcagaccatt cgcactggca
    14341 aaagattgaa ccgaataggc ccataccagt tcctgtacga taccggcacc gatacctgtc
    14401 acgagataga aggtaaggaa acgtttcggt ccccacacat tttctagtac acgtccaaac
    14461 atatacaccc cgaacatatt aaaaaagaca tgtgcaaaag agtgcgtatc gtgcatgaac
    14521 atataagtaa caaactgaaa cgggtagaaa tctttcacac ccggaaagtg caatcccaat
    14581 agttgcacca aatcaatccc tactttcggc aacaccagac tggctaccca gaatagcagg
    14641 ttgataatga taaggttttt tgtaacgggc ggtatactat tcaagaaccc ggagccattt
    14701 tgattcatca tacatatatc aatttgcggg caaaggtaaa tatattttga ttgtttttcc
    14761 ttcaaatagt actaaaacat agtaaatcaa taaaaaaaac agattttttc tttgcagaat
    14821 atcaaattaa aactacattt gaaccgactt tcaggctatc acagatttgt ttaatatatt
    14881 aattatcaat ccatcatgaa caaaacagaa tttatcacag ctgtagcgga aaaatccggt
    14941 ttaagtaagg ctgatgccaa gaaagcagta gatgcttttg ttgaaacagt atccgacgaa
    15001 atgaaagcag gaggaaaaat tgctcttcta ggtttcggtt cattctccgt aactgaaaaa
    15061 gcagcccgca aaggcgttaa cccaaagaca aaacaaccca ttgaaatcgc agctcgcaaa
    15121 gccatcaaat ttaaacccgg cgcagagtta aacgacaagg ttcagtaaga aacggaatat
    15181 tttcatattc gaagaggtgt tgcaaaagtg tcatttgtca gttttacaac accttcttta
    15241 ttctttcatt gttggaatgt tgttttatca tatattgtga tacagtattc gcatatatta
    15301 tgatactgca ttctcatata ttatgatatt cttttcgcat aatatatgat aaaataattc
    15361 cagagaacat cactgccccc tggaacccac actagtatta atattaaact tacctgatta
    15421 cacaggttag tattgttatt ccgaacaaaa catgattacg ggacttcggt cccgtttcat
    15481 ctatcacatt acaaagatcc tgcttttcaa tcaattatca ttgtatttat ggttctcatg
    15541 ccgcaccagg cgactccaga aagcctcttt gtaagcaact gctgttatct taatttcatt
    15601 ttccgcaaca acgagaatac gtcaaacata tatactctct atttgcagac catccgctcc
    15661 gcacagcacg aatagagtaa atcaaatgaa ttatgcgatc aaagaccacc ctcatgctgg
    15721 aaataccagg tccatccgtt aatattaatc tgaaggacca gccagggatc gttgtcggca
    15781 aagaaaaaga cgatcttata ttcactctcc cggtcaagat attcctgagc gctcatatta
    15841 tgcccttcga tttttgtcat caccagaaaa tcggtcagat tgatattgaa taccttttta
    15901 cctgtagcct tctctgttac cacaaaacgg gcgttacggt tcgctagaaa ccgcatcgta
    15961 ttcagttcga caatacctgc tgccagattc ttttgttcga tatgataagg acggaaacta
    16021 agattatcat ctccaagcag cgaattatcg tgtgccagat aaccgttgga ttcgattatt
    16081 tcataggtat aggcattcac atctaccccc caggagtctt cattgcttcc ctgaaaaaca
    16141 aaccgtactt tattggtatc ttttatcagg ttgatgacct ccgtctgatc ggtggtaccg
    16201 gtaaagtcca cgttattaat ctcgccatac caaagcggct cgagttcctt atcaatgata
    16261 agtgtttcct cacgtttcaa ttgcagcttc aggtcagcga tggaggaaac acctgcctgc
    16321 aacgatgtta tatcatatga atcatgtgca cctgcccatg ccataaactg gtattgtccg
    16381 acaggtaact taacttccat caaataactg cctgttccca acatactccc ttcctctgct
    16441 tgtttaaaca ggaacttgcc gtttttatca aatacataaa gctccacttt atccacctgc
    16501 gaatggaatg catcagcaaa ttccatattg taatcatact taaacttaac aaacaaacgg
    16561 cactccggca gatcttcgtt aaagctatcg catgaagtca ttatcaggga gccgataagg
    16621 acaaaccaca tgtctatgtg acgtaatagg ctttttagct tcatattttt cagttttcta
    16681 attattctat atatagagga aaagatattt cttcttttct cgttatttcc aattcaatgg
    16741 acagaactgc ctgttctgtc aaatacaaat cccagagttt tatcaagtct ccggcaactc
    16801 ttttgctaaa aataaagggg ggtgtcacaa aagtctgttt tgtcatggcg gacttgatcc
    16861 gccaactcat actagattaa atacattatt aatatgcgat cccgggacaa gcccgggatg
    16921 acaggatagt gacttttgac acacctcctt ttatattaaa aagatttcgt aattataaat
    16981 ctatctcttg tctata
//
