LOCUS       c00009_gnlPro..        14150 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KNBJLEMJ_9.
ACCESSION   c00009_gnlPro..
VERSION     c00009_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 07:07:37
            Original ID  :: gnl|Prokka|KNBJLEMJ_9
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14150
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14150
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[53:4150]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      54..4150
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14150
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14150
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             54..1718
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.7e-46, bitscore:
                     149.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMRSLEHQGVTTIFGYPGGSIMPTFDALYDHQNTLNHILVRHEQG
                     AAHAAQGYARVSGKVGVCLVTSGPGATNTITGIADAMIDSTPIVVIAGQVGTGFLGTDA
                     FQEVDLVGITQPIAKWSYQIRRAEDVAWAIARAFYIASSGRPGPVVLDFAKNAQVEKTK
                     YEPTQQEFIRSYVPVPDTDEESVKAAAELINNAERPLVLVGQGVELGSAQEELRIFIEK
                     ADMPAGCTLLGLSALPTDHPLNKGMLGMHGNLGPNINTNKCDVLIAVGMRFDDRVTGNL
                     ATYAKQAKVIHFDIDPAEVNKNVKVDIAVLGDCKKTLAAVTGLLKKNRHTEWVDSFKEY
                     EAVEEEKVIRPELHPATDSLSMGEVVRAVSEATRHEAILVTDVGQNQMISARYFKYTRE
                     RSIVTSGGLGTMGFGLPAAIGATFGRPDRTVCVFMGDGGLQMNIQELGTIMEQKAPVKI
                     ICLNNNYLGNVRQWQAMFFNRRYSFTPMLNPDYMKIASAYDIPSKRVFSREELKAAIDE
                     MLSTDGAFLLEACVVEEGNVLPMTPPGGSVNQMLLEC"
     CDS             1737..2300
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_2"
                     /sec_met_domain="ALS_ss_C (E-value: 6.5e-19, bitscore:
                     60.9, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSDKTLYTIIVHSENIAGLLNQVTAVFTRRQINIESLNVSASSIK
                     GVHKYTITAWTDKDTIEKVVKQIEKKIDVIQAHYFTEDEIYFHEIALYKVSTPAFQETP
                     EASKVIRRYNARIVEVNPVFSIVEKNGMSEEITSLYEELRALKCVLQFVRSGRVAITTS
                     CFERVNEFLDGQEAKYKQSKKEQE"
     CDS             2300..3043
                     /locus_tag="ctg9_3"
                     /transl_table=11
                     /translation="MSEENKIGTYQFVAEPFHVDFNGRLTMGVLGNHLLNCAGFHASDR
                     GFGIATLNEDNYTWVLSRLAIELDEMPYQYEKFSVQTWVENVYRLFTDRNFAVIDKDGK
                     KIGYARSVWAMINLNTRKPADLLALHGGSIVDYICDEPCPIEKPSRIKVTSNQPVATLT
                     AKYSDIDINGHVNSIRYIEHILDLFPIELYQTKRIRRFEMAYVAESYFGNELSFFCDEV
                     SENEFHVEVKKNGSEVVCRSKVIFE"
     CDS             3107..4150
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg9_4"
                     /sec_met_domain="IlvN (E-value: 3.9e-46, bitscore: 149.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.1e-39, bitscore: 128.0,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGTVENVVIRDEFPLEKAREVLKNETIAVIGYGVQGPGQ
                     ALNLRDNGFNVIVGQRQGKTYDKAVADGWVPGETLFGIEEACEKGTIIMCLLSDAAVMS
                     VWPTIKPYLTAGKALYFSHGFAITWSDRTGVVPPADIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAIYQDATGNAMDRTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYHSVKTGNEAQISIDSNSKPDYREKLEEELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(4683..6629)
                     /locus_tag="ctg9_5"
                     /transl_table=11
                     /translation="MKYIFVSGRRFITFASIMNNHPKSPIIDLQQQQLLLRMEYEHEKE
                     EFKRQTETMGVARKVKRGLCWYPASPGRSYYNSLNQLVIDITRTENKEIEHSFEFGRPV
                     CFFRQSFDGKVNYMNFIATVSYADDERMVVVLPSAGALLELQTEEVLGVQLYFDETSYR
                     AMFEALEDTIRAKGNRLAELRDTLLGTQKPGFRELYPVRFPWLNSTQETAVNKVLCTRD
                     VAIVHGPPGTGKTTTLVEAIYETLHREPQVLVCAQSNTAVDWICEKLVDRGVPVLRIGN
                     PTRVNDKMLSFTYERRFENHSAYPELWGIRKSIREMGSRMRRGSYSEREGMRSRMSRLR
                     DRATELEILINADLFDSARVIASTLVSSNHRLLNGRRFPTLFIDEAAQALEAACWIAIR
                     KADRVILAGDHCQLPPTIKCIEAARGGLDHTLMEKVVQQKPSAVSLLKVQYRMHEAIMR
                     FPSEWFYNGELEAAPEVRNRGILDFDTPMNWIDTSEMDFHEEFVGESFGRINKQEANLL
                     LQELEAYISRIGKARILDESIDFGLISPYKAQVQYLRSKIRGSSFLRPFRSLITVNTVD
                     GFQGQERDVVFISLVRANEDGQIGFLNDLRRMNVAITRARMKLVILGDATTLTKHAFYR
                     KLIQYIRQEAVSS"
     CDS             6696..8939
                     /locus_tag="ctg9_6"
                     /transl_table=11
                     /translation="MVYDLTMLEAFYSAYKGKVEHVRAVLKRPLTLAEKILYAHLFNEG
                     DLKNYKRGEDYVNFRPDRVAMQDATAQMALLQFMNAGKEKVAVPSTVHCDHLIQAYKGA
                     KEDIATATKTNEEVYDFLRDVSSRYGIGFWKPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRIIGVRLTGKLSGWTSPKDVILKLAGI
                     LTVKGGTNSIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPFDGRMATYLRATGRD
                     RIVELAEAVDCELRADQQVTDEPEKYYDRVIDIDLSTLEPYINGPFTPDAATPISEFAE
                     KVLLNGYPRKMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLSVASPLIINPGSEQIRA
                     TAERDGMMDDFMQIGAVIMANACGPCIGQWKRHTDDPTRKNSIVTSFNRNFAKRADGNP
                     NTYAFVASPELTMALTIAGDLCFNPLKDRLMNHDGEKVKLAEPEGEELPLRGFTSGNEG
                     YIAPGGTKTAINVNPASQRLQLLTPFPAWDGQDILNMPLLIKAQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNNVWNRSTNTYGTVSGTAKMYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNLKKQGMLALTFADKADYDKIQEHD
                     LLSVIGLPDFAPGRNLTVVLHHEDGTKESFEAQHTYNEQQIAWFRAGSALNAR"
     CDS             8969..10144
                     /locus_tag="ctg9_7"
                     /transl_table=11
                     /translation="MQKDGTLSVPDVPVVPYITGDGVGAEVTPSMQAVVNAAVQKAYGG
                     KRRIEWKEVLAGERAFNETGSWLPDETMKAFQEYLIGIKGPLTTPVGGGIRSLNVALRQ
                     TLDLYVCLRPVRWYQGVHSPVKAPEKVNMCVFRENTEDIYAGIEWEAGTPEAEKFYQFL
                     KNEMGVTKVRFPETSSFGVKPVSREGTERLVRAACQYALDHHLPSVTLVHKGNIMKFTE
                     GGFKKWGYELAQREFGDALADGRLVIKDCIADAFLQNTLLIPEEYSVIATLNLNGDYVS
                     DQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDVVNPCSIILSAVMMLEYL
                     GWKEAAALIEKALEQSFLDARATHDLARFMPGGTSLSTTAFTREIVERIEK"
     CDS             10170..11513
                     /locus_tag="ctg9_8"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEEMKEATRIDNELFPKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVEDISHAIIKEKRFGFEEVAYLLLSGRL
                     PDKEELASFCELINDNMALEQKTKMNIIELEGNNIMNILSRSVLEMYRFDPDADDTSRD
                     NLMRQSIDLISKFPTIIAYAYNMLRHATFGRSLHIRHPQEKLSIAENFLYMLKKDYTEL
                     DARTLDLLLILQAEHGGGNNSTFTVRVTSSTGTDTYSAIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIKDWKSVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRALLLKEL
                     ARDLAREKGKEEEFAFLELLEERAIATFGRVKNNGKTVSSNIDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDDLAYIPIKKR"
     CDS             12011..12772
                     /locus_tag="ctg9_9"
                     /transl_table=11
                     /translation="MSITAFNLFLGVMSLIALIVFIALYFVKAGYGIFRTASWGVAISN
                     KLAWILMEAPVFLVMCWMWMHSERRFDPVILTFFIFFQIHYFQRAFVFPLLLTGKSKMP
                     LAIMSMGILFNLLNGYMQGEWIFYLSPEGMYHSGWFTSAWFIAGSLLFFAGMLMNWHSD
                     YIIRHLRKPGDTRHYLPQKGMYRYVTSANYLGEIIEWAGWAILTCSLSGLVFFWWTVAN
                     LVPRANAIWHRYREEFGSEVGGRKRVFPFIY"
     CDS             12811..14034
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Oxidored_FMN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg9_10"
                     /sec_met_domain="Oxidored_FMN (E-value: 2.2e-52, bitscore:
                     171.3, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESKLFTPVTFGPLTLRNRTIRSAAFESMCPGNAPSQMLLDYHRS
                     VAAGGVGMTTVAYAAVTQSGLSFDRQLWLRPEIISGLREVTGAIHTEGAAAGIQIGHCG
                     NMSHKKICGTTPISASTGFNLYSPTFVRGMKKEELPEMARAYGRAVHLAREAGFDAVEV
                     HAGHGYLISQFLSPYTNHRKDEYGGSLENRMRFMEVVMNEVMTAAGSDMAVFVKMNMRD
                     GFKGGMETDETLQVAKRLLALGAHALVLSGGFVSKAPMYVMRGAMPIRSMAYYMDCWWL
                     KYGVRMFGKWMIPTVPFREAYFLEDALKFRAALPEAPLIYVGGLVSREKIDEVLDAGFD
                     AVQMARALLNEPEFVNRMRREEQARCNCGHSNYCIGRMYTIEMACHQHLKEKLPPCLQR
                     EIEKLEKQ"
ORIGIN
        1 ccattatcca ttaaagaact atgagtaagg acttaataac aggcgcagag gcaatgatgc
       61 gctctctgga acatcaggga gtgactacca ttttcggtta tcccggcggt tccatcatgc
      121 ctacgttcga tgccctgtac gaccatcaaa atacattgaa ccatatcttg gttcgccatg
      181 aacagggagc tgcccatgcg gcacaaggct acgcccgtgt atcgggtaaa gtcggtgttt
      241 gcttggtgac aagcggcccc ggagcaacca atacgatcac aggtattgca gatgcgatga
      301 tagacagtac gcctatcgtt gtcattgcag gacaggtggg aacaggcttt cttggaacag
      361 acgcttttca ggaagtcgat ctcgtaggta tcactcagcc aatcgctaaa tggagctatc
      421 agattcgccg tgccgaagac gtagcctggg cgatagcacg tgctttctac attgccagta
      481 gtggtcgtcc cggtccggtg gtactcgact ttgccaagaa tgcgcaggtt gaaaaaacaa
      541 aatacgagcc gacgcagcag gagtttatcc gcagctatgt tccggttccc gatacagacg
      601 aagaatcagt aaaggctgcc gccgaactga tcaataacgc cgaacgcccg cttgtcttgg
      661 taggacaggg agtggaactg ggaagcgctc aggaagaact gcgtatcttt atcgaaaagg
      721 cggatatgcc cgcaggttgt accttgctcg gactttccgc attgcctacc gaccatccgt
      781 tgaataaagg aatgctgggt atgcacggaa atctgggacc gaatatcaat actaacaaat
      841 gtgatgtact gattgctgtc ggtatgcgtt tcgacgaccg tgtgaccggt aatctggcta
      901 cttacgccaa acaagcgaaa gtgatccatt ttgacattga tccggcggaa gtaaataaga
      961 atgtaaaggt agacattgcc gttttgggcg actgcaaaaa gacgctggct gctgtgaccg
     1021 gactgctgaa aaagaaccgg cacaccgagt gggtcgatag tttcaaggaa tatgaagcgg
     1081 tagaggaaga aaaagtcatt cgtcccgaac ttcatcctgc aacggattca ctgagtatgg
     1141 gcgaagtggt gcgtgcggta agcgaagcga cccgtcacga agccatattg gtgacagatg
     1201 taggtcagaa tcagatgatc tctgcccgct actttaaata taccagggaa cgtagtatcg
     1261 ttacttcggg tggacttggc acgatgggtt ttggccttcc ggcagctatc ggagctactt
     1321 tcggccgtcc cgaccgcact gtatgtgtat ttatgggtga cggcggactg caaatgaaca
     1381 ttcaggaact gggtacgatc atggaacaga aagctccggt gaagattatc tgcctgaaca
     1441 acaattatct cggcaacgtg cgccaatggc aggctatgtt ctttaatcgc cgttattcat
     1501 ttactccgat gctgaatccg gattacatga aaatcgcttc cgcctacgat attccttcca
     1561 aacgtgtctt ttcacgggaa gaattgaaag cggccatcga cgaaatgctc tcgacagacg
     1621 gggcgttcct gctcgaagcc tgtgtggtag aagaaggcaa tgtcctcccg atgacccctc
     1681 cgggcggttc agtcaatcag atgttgctgg aatgttaatc cttaatttag aaagttatga
     1741 gtgataagac attatatacg attatagttc attctgaaaa tatagccgga ttgctgaatc
     1801 aggtgaccgc tgtatttacc cgtcggcaaa taaacatcga gagtttgaac gtttctgctt
     1861 cttccattaa aggagtacat aaatatacga ttacagcgtg gactgataag gacactatcg
     1921 aaaaggtggt gaagcagatc gaaaagaaga ttgatgtgat tcaggcgcac tattttacgg
     1981 aagacgagat ttatttccat gagatagcct tatataaggt atctactcct gcttttcagg
     2041 agactccgga agcatctaaa gtgatccgca gatataatgc ccgcattgta gaggtgaatc
     2101 cggtattctc tatcgtcgag aagaacggca tgagtgaaga gattacttcc ctttacgaag
     2161 aacttcgggc tttgaaatgt gtgctgcaat ttgtccgttc gggccgtgtg gctattacta
     2221 ccagctgttt cgaacgtgtg aatgagttcc tggacggaca ggaagcgaag tataagcaaa
     2281 gtaaaaagga acaggagtaa tgagtgaaga aaataaaata gggacttatc agtttgtggc
     2341 agagccgttt cacgtagatt ttaacggccg cctgaccatg ggcgtgctgg ggaatcatct
     2401 gctgaattgc gcaggttttc atgccagcga ccgtggattt ggtattgcta cgctgaacga
     2461 ggacaattac acatgggtgc tttcccgtct ggcgatcgag ctggacgaga tgccttacca
     2521 atacgagaag ttctcggttc agacatgggt ggagaatgtc tatcgtctct ttaccgaccg
     2581 taactttgcc gtcattgaca aggatggaaa gaagatcggc tatgcccgtt ccgtatgggc
     2641 gatgatcaat ctgaatactc gtaagcctgc cgatctgttg gcattgcatg gaggaagcat
     2701 cgtcgattat atatgcgatg aaccctgccc gatagaaaag ccttcgcgta tcaaggtgac
     2761 aagcaatcag cctgttgcga cgctgacggc aaaatacagt gatatcgata ttaacggaca
     2821 cgtaaacagt attcgttata tcgagcacat acttgacttg tttccgatag aactgtatca
     2881 gacgaaacgt atccgccggt ttgaaatggc gtatgtggct gaaagttatt tcggaaatga
     2941 actctctttc ttctgtgatg aggtgagtga aaacgagttt catgtagagg tgaagaaaaa
     3001 cggcagcgag gtagtatgcc gttccaaagt gatatttgaa taatatagag tataaaatca
     3061 attaataaca gatggcgcaa gtcatcaaaa caaaaaaaca aaaaaaatgg cacagttgaa
     3121 ttttggcgga actgtagaaa atgtagttat ccgtgatgaa tttccattgg aaaaagctcg
     3181 tgaagtattg aaaaatgaaa caatcgctgt aatcggttat ggcgtacaag gtcccggaca
     3241 ggctctgaac cttcgtgata acggtttcaa tgtaatcgtt ggtcaacgcc agggaaagac
     3301 atatgacaaa gcggttgctg acggatgggt tccgggtgaa actttgttcg gtattgaaga
     3361 agcttgcgaa aaaggtacga tcattatgtg cctgttgtct gatgcagcag taatgtctgt
     3421 atggcctact atcaagcctt acctgactgc aggaaaagct ctttatttct ctcatggttt
     3481 tgctattaca tggagtgacc gcacaggtgt agttcctcct gcagatatcg acgtaatcat
     3541 ggttgctcct aaaggttcgg gtacatcctt gcgtactatg ttccttgaag gtcgcgggtt
     3601 gaactcttca tacgctatct atcaggatgc aacaggcaac gctatggaca gaacaatcgc
     3661 attgggtatc ggtatcggtt caggttattt gttcgaaaca actttcatcc gcgaagctac
     3721 ttccgacctg acaggcgaac gtggttcatt gatgggagct atccagggtc tgttgctggc
     3781 acaatacgaa gtgttacgtg aaaacggtca cactccttcc gaagcattca acgaaactgt
     3841 agaagagctg actcagtcat tgatgccgtt gtttgcaaag aacggtatgg actggatgta
     3901 tgctaactgc tctactacag ctcaacgtgg tgctctcgac tggatgggcc ccttccacga
     3961 tgctatcaaa ccggtcgttg aaaagttgta tcacagtgtg aagactggta acgaagcaca
     4021 gatttcaatc gactctaact ccaaaccgga ttatcgtgag aaactggaag aagaactgaa
     4081 agcattgcgc gaaagcgaaa tgtggcagac tgccgtgaca gttcgtaaac ttcgtccgga
     4141 aaataattaa tcagacttat actatataag tttttcaaaa ggcgggaaaa tcatcttttc
     4201 ccgcctcttt tatgtgtatg ccactctttt gaatgacaga ataaggatga aagtagcaaa
     4261 aaagattaaa agatactgat aatataggtg aaaaagagca tttatgatta cctttacggc
     4321 aacaaataaa acagaatagg caatgaagaa actttttact tacagaaaat cgatacgtat
     4381 gaagatgatt tcttctttaa tgaatagtat atcagaatgt tacattaaaa gatatttaag
     4441 ttattctcta ccgaatggta gctgtaatac catttcaagt cctttttata tttcgtgttc
     4501 cattagtgat tcgttgatat gatgcagaat tttattctgt agcaggaaaa agtatgcgtt
     4561 aaattgaatt taagacagag cttttggaac agaatttagt gggaaaataa cattgtttgt
     4621 tttgtttgta aatgggagtc ttctttcgtg agaaaggggg cttctttttt tatcccgatg
     4681 attcaggagg ataccgcttc ctgccggata tactgtatca gtttccggta gaacgcatgc
     4741 ttggtaagag tggttgcatc tcccaaaatc acaagtttca tccgggcgcg ggtaatggct
     4801 acgttcattc gtcttaaatc attcagaaaa ccgatctgtc cgtcctcgtt cgcccggacg
     4861 aggctgataa agacgacatc ccgttcctgt ccctgaaagc cgtctaccgt gttgaccgtg
     4921 atgaggctgc ggaaagggcg gagaaaactg cttcctctga ttttacttct caggtattgc
     4981 acttgcgcct tgtagggcga aatcagacca aagtcgatgc tctcgtccag gatgcgtgct
     5041 ttgccgatcc ggctgatata ggcttccagt tcttgcagta acaagttggc ttcctgcttg
     5101 ttgatgcgcc cgaagctctc gcctacaaac tcttcgtgga agtccatttc cgaggtatct
     5161 atccagttca tgggagtgtc gaagtcaagg ataccccggt tgcgcacttc cggtgcggct
     5221 tccagttctc cgttgtagaa ccattcggag ggaaagcgca tgattgcctc gtgcatccgg
     5281 tattgcactt tgagcagcga gacggcagaa ggtttttgct gcacgacttt ttccattaaa
     5341 gtatggtcca gtccgccacg ggcggcttcg atacatttga ttgtaggagg gagctggcaa
     5401 tggtcgccgg caagaatcac acggtcggcc tttcggatgg cgatccaaca ggcggcttcg
     5461 agtgcctggg cggcttcatc gataaataag gtggggaaac gccgtccgtt gagcaaacgg
     5521 tgattgctgc tgaccagcgt ggaagcaatc acacgggcac tgtcgaaaag atcggcgttg
     5581 atcaggattt ccagttcggt ggcacggtcg cggaggcggc tcatccggct gcgcattcct
     5641 tccctttcgg agtaacttcc ccgacgcatc cggctgccca tttcacggat cgattttcgg
     5701 attccccaaa gttcggggta ggccgaatga ttctcaaagc ggcgttcgta agtgaaagaa
     5761 agcattttgt cattaacacg tgtagggtta ccaatgcgga ggacaggcac accccggtct
     5821 accagtttct cgcaaatcca gtccacagcc gtattacttt gggcgcagac cagcacctgc
     5881 ggttcgcggt gaagcgtttc gtaaatggct tccacgagcg tggtagtctt tccggttccc
     5941 ggagggccgt gaacgatggc gacatcgcgt gtgcataaca ctttgtttac ggctgtttcc
     6001 tgcgtgctgt tcagccacgg gaaacggacg ggatataatt cgcggaatcc cggcttttgt
     6061 gttcccagca aggtgtcccg gagttcggca aggcggttgc ccttagcgcg gattgtgtct
     6121 tccagcgctt cgaacatggc acgataggac gtttcatcga aataaagttg tacacccagc
     6181 acctcttccg tttgcagttc cagcaaggcg cccgcactgg gaagcacgac caccatccgt
     6241 tcgtcgtccg cataactcac cgttgcaatg aaattcatgt aattcacttt tccgtcaaat
     6301 gactgccgga aaaagcagac gggacgaccg aattcgaagg aatgctcgat ttctttattt
     6361 tcggtgcgtg taatatctat tacaagttga tttagagaat tatagtaact tcgaccggga
     6421 gaggcgggat accagcacag accacgtttc actttgcggg cgacacccat tgtttcagtc
     6481 tgccgcttga attcctcctt ttcgtgttca tactccatgc gtagcaggag ttgctgttgc
     6541 tgaaggtcga tgattggact tttcggatga ttattcataa tagacgcaaa ggtaataaat
     6601 cttcttcctg agacgaaaat atatttcatt ttgttaaaca ttcctcgaac gccgttcgtt
     6661 atttttatag atagactaaa aaaaataaaa gcaatatggt gtatgatttg actatgttag
     6721 aggcttttta ttctgcttat aaaggaaaag tggaacacgt gcgggctgtt ttgaaacgcc
     6781 cattgacgtt agccgagaag attctgtatg cccacctgtt caatgagggc gatctgaaaa
     6841 actacaagcg gggtgaagac tacgtaaatt tccgtcccga ccgcgtcgct atgcaggacg
     6901 cgactgccca gatggcattg cttcaattca tgaatgcagg aaaagaaaaa gtggctgttc
     6961 cctccaccgt gcactgtgac cacttgatac aggcgtacaa aggagcaaag gaggacattg
     7021 ctacggcaac caaaacaaac gaagaagttt acgacttttt gcgcgatgta tcctctcgct
     7081 acggcatcgg cttttggaag ccgggtgccg gtatcattca ccaggtagtg ctcgaaaatt
     7141 acgctttccc cggcggaatg atggtaggaa ccgactctca cactccgaat gccggaggac
     7201 tgggcatggt ggccatcggc gtcggcggtg cggatgccgt agacgtgatg acaggtatgg
     7261 aatgggaact gaaaatgcca aggattatcg gtgtccgcct gaccggaaaa ctgagcggct
     7321 ggacttcccc gaaagatgtc atcctgaaac ttgcagggat tctgaccgta aaaggaggca
     7381 cgaactccat catcgaatat ttcggaccgg gaacagcttc cctgtcggct accggcaaag
     7441 cgaccatttg caatatgggt gcggaagtag gagctaccac ttcgcttttc ccgttcgacg
     7501 ggcgcatggc tacttatctg agagccaccg gcagggatcg catcgtggaa ctggcggaag
     7561 ccgtggactg tgagctccgt gcggaccaac aggtgacgga cgaaccggaa aagtactacg
     7621 accgtgtcat cgacatcgat ttgtctacgc tcgaacctta tatcaacggc cctttcacac
     7681 cggatgccgc tacccctatt tctgaatttg cagaaaaagt attactgaac ggctatccgc
     7741 gtaagatgga agtcggactg atcggttcgt gtaccaactc ttcttaccaa gatctcagcc
     7801 gtgccgcatc ccttgcaagg caggtgaagg aaaagaatct gagtgtggct tccccgttga
     7861 tcatcaatcc gggttccgag caaatccgcg ctactgccga aagagacgga atgatggatg
     7921 acttcatgca gatcggcgcc gtgatcatgg caaatgcctg cggtccttgc atcggtcagt
     7981 ggaaacgtca tacggacgac ccgacgcgga agaactcgat cgtcacatcc ttcaaccgta
     8041 actttgccaa acgtgcggac ggcaatccga acacatacgc ctttgttgct tctcccgaac
     8101 tgacgatggc actgaccatt gccggtgatc tttgcttcaa tccgctgaaa gacagactga
     8161 tgaaccatga cggcgagaaa gtgaaactgg ccgaaccgga aggcgaagaa ctccccttga
     8221 gaggatttac ctccggtaat gaaggctata tcgcccccgg cgggacgaaa acagcgatca
     8281 acgtcaaccc ggcttcccaa cgcctgcaac tgctgactcc tttccccgct tgggacggac
     8341 aagatatact caatatgccc ctgctgatta aggcgcaggg caaatgtact accgaccata
     8401 tttcgatggc gggaccgtgg ctgcgttttc gcggacattt ggagaatatt tcggataata
     8461 tgctgatggg agccgtgaat gctttcaatg gcgaaacgaa caacgtgtgg aaccgttcga
     8521 caaacaccta cggaaccgtt tcgggcacag ccaaaatgta taaatccgaa ggaatcccct
     8581 ccattgtcgt ggctgaagaa aattacggag aaggctccag tcgcgagcac gcggcaatgg
     8641 aaccccgttt cctgaatgtg cgtgtgattc tcgccaagag cttcgcccgt atccacgaaa
     8701 cgaatctgaa aaagcagggc atgcttgccc ttacctttgc ggataaagcg gattatgaca
     8761 agatacagga gcacgacctc ctttcagtca tcggcttgcc cgactttgct ccgggacgga
     8821 atctgaccgt cgttcttcat cacgaagacg gaacgaaaga gagttttgaa gcgcaacata
     8881 catacaacga acagcagatt gcctggttcc gtgccggctc tgccttgaat gccagataat
     8941 taaaatgata gaaatgaaca aaataaccat gcaaaaagat ggtacgctgt cggtgcccga
     9001 tgtgcctgtc gtaccttata ttaccggaga cggagtagga gcggaagtga ctccgtcaat
     9061 gcaagccgtt gtgaacgcgg ctgttcagaa agcatacggc ggcaaacgtc ggattgaatg
     9121 gaaagaagtg ctggcgggcg aacgcgcttt caacgagaca ggctcttggc tgccggatga
     9181 aacgatgaag gctttccaag aatatctgat cggcatcaag ggtccgctga cgacccctgt
     9241 cggcggtgga atccgttctt tgaacgtagc tttgcgccaa accttggatt tatatgtttg
     9301 tttgcgtccg gttcgttggt atcaaggcgt tcattctccg gtgaaagcac cggaaaaagt
     9361 gaacatgtgt gtgttccgtg aaaatacgga ggatatatat gcaggaatcg agtgggaggc
     9421 aggtactccc gaagccgaaa agttctatca attcctgaaa aacgagatgg gagtgacgaa
     9481 agtccgcttc cccgagacct cttcttttgg ggtgaaacct gtttcccgtg agggcacgga
     9541 acgtcttgtg cgggctgcct gccagtatgc gctcgaccat catctgcctt ctgtgacact
     9601 ggtgcacaaa ggaaacatta tgaagttcac cgaaggaggt ttcaagaaat ggggctatga
     9661 gctggcgcaa cgtgagtttg gcgacgcgct ggcagacggc cggctggtga taaaggactg
     9721 cattgccgat gcttttctgc aaaatacatt actgattccc gaagagtatt ccgtgattgc
     9781 cacgctgaac ctgaacggag actatgtttc cgaccagttg gcggcaatgg taggcggcat
     9841 cggcattgct ccgggagcaa atattaacta caagacgggg cacgccattt ttgaagcgac
     9901 tcatggaacc gcccccaaca ttgccggaaa ggatgtcgtg aatccttgtt ctatcattct
     9961 ttcggcggtg atgatgcttg aatatctggg atggaaagaa gcggccgcgc ttatcgaaaa
    10021 ggcgctggaa cagagtttcc tcgatgcccg tgccacgcac gatctggctc gctttatgcc
    10081 gggaggtaca tccctgtcta ccaccgcttt cacacgcgaa attgtggaaa gaatcgaaaa
    10141 gtaaatgtaa cgattaaaaa cgaagtatta tgaagaaaga gtatttgatt tacaagctct
    10201 ccgaggagat gaaagaggca acccggattg acaatgaatt gttccccaag tttgacgtga
    10261 agcgtggact acgtaatgaa gacggcaccg gtgtattggt aggtctgaca aagattggta
    10321 atgtggtggg ttacgaacgt atccccggcg gcggtctgaa gcctattccg ggaaaattgt
    10381 tctatcgagg ctatgatgtg gaagacattt cccacgccat catcaaggaa aaacgtttcg
    10441 gcttcgaaga agtggcttat ctgctactct ccggtcgtct gccggacaag gaagaactgg
    10501 cttcgttctg cgaactgatc aatgacaata tggcgctcga gcagaagacg aaaatgaata
    10561 ttatcgagct ggagggaaat aatatcatga atatcctttc gcgcagcgta ctcgaaatgt
    10621 atcgtttcga tcccgatgcc gacgatactt cccgcgacaa tctgatgcgc cagagtatcg
    10681 atcttatctc caagttcccg accatcattg cgtatgctta taatatgctc cgccatgcta
    10741 cattcggccg ttccctgcat atccgtcatc cgcaggaaaa actctctatt gccgagaatt
    10801 tcctctatat gctcaaaaaa gattatacgg aactggatgc ccgtacgctc gacttgctat
    10861 tgattttgca ggcagaacat ggcggtggta acaactcgac tttcacggtt cgtgtgactt
    10921 cttccaccgg aacagataca tactcggcca tcgccgcagg tatcggttcg ttgaaaggcc
    10981 cgcttcacgg aggcgcgaat atccaggtgg ccgatatgtt ccatcacttg caggagaaca
    11041 tcaaggactg gaagagcgtg gacgagatag atacctattt cacacggatg ctgaataagg
    11101 aagtgtataa taagaccgga ttgatttacg gtatcggtca tgctgtttat acgatttccg
    11161 atcctcgtgc gctgttgctg aaagaactgg ctcgcgacct tgcccgtgag aaaggaaaag
    11221 aagaggagtt cgctttcctc gaactgcttg aagagcgtgc catcgctact ttcggacgtg
    11281 tgaagaacaa cggaaagacg gtttccagca atatcgactt ctattcgggc ttcgtatatg
    11341 agatgattgg tttgccgcag gagattttca ctccgctgtt tgccatggct cgtattgtcg
    11401 gctggtgtgc gcaccgcaat gaagaactga acttcgaggg caaacgcatt atccgtccgg
    11461 cttataaaaa tgttcttgat gatctggctt atatccccat caagaaacgc tgataagaac
    11521 aaatcctttt atgcaataat aactaacctc agacgtacat ctcggcaatc cctgcatgta
    11581 cgtctcggta atccccagtt gtacatcttg gtagtacccg gttgtacgtc tggggtgact
    11641 tgtttcagga agaacgtccg atgttcattt aacatttaac actttgcggc tgctgtattt
    11701 ttcatccgat ggaggctaag gcatttatcg ttggtagaaa gggcacagcc tggcaggtag
    11761 aaacgccctt ttaacgctac gttaaaaggg cgtttctaca atcgatgaat tatatattct
    11821 attcctttgg atatcagtga actatgtgct aaaagcccat ggtgtcatat gaaagagaac
    11881 acgggatgga aaaaagataa ttgtgatatt cataagtttc ctgtccggtc aatacgaata
    11941 gttctttcgg ttttttgtgg ccattctttt ctttttttgt tatttttgtg aatctcaaaa
    12001 gaaaatcaag atgagtataa ctgcctttaa tctatttttg ggcgtcatga gtctgatcgc
    12061 tctgattgtt ttcatcgccc tctactttgt gaaagccggt tatgggatat ttcgcactgc
    12121 ctcctgggga gtcgccattt ccaacaagct ggcgtggata ctgatggaag cccccgtatt
    12181 tctggtcatg tgctggatgt ggatgcactc ggaacgtcgt tttgatccgg tcatactgac
    12241 attctttatc ttctttcaga ttcattattt tcagcgcgcc ttcgtctttc ccctgctact
    12301 gaccggaaag agcaaaatgc cgctggcaat tatgtcgatg ggaatcctgt tcaatctatt
    12361 gaacggctat atgcagggcg aatggatatt ttatctctca cccgagggaa tgtatcattc
    12421 cggctggttc acttccgcat ggtttattgc gggcagtctg cttttctttg caggtatgtt
    12481 gatgaactgg cattcggact atatcatccg tcatttgcgc aaaccggggg atacccgtca
    12541 ttatctgccc caaaaaggga tgtaccgcta tgtcacttcc gccaattatc tgggcgaaat
    12601 catcgaatgg gcaggctggg caatactgac ctgttcactg tccggacttg tattcttctg
    12661 gtggacagtg gccaatctcg tcccccgtgc caatgcaatc tggcatcgct accgtgaaga
    12721 atttggctcg gaagtaggcg gacgcaaacg tgtatttcct tttatctatt gatttgaaat
    12781 aaattatcta ttgacataaa atagcgtact atggaatcta aacttttcac ccctgtcact
    12841 ttcggtccat tgacgctgcg gaatcgtacg atccgctctg ccgcttttga aagcatgtgt
    12901 cccggtaacg ccccttcaca aatgctgctc gattaccacc gctcggtggc tgcgggcgga
    12961 gtcgggatga cgactgtagc ctatgcagcc gtgacgcaaa gcggactttc tttcgaccgt
    13021 cagttgtggc tgcgtccgga aatcatttcc ggtttacgtg aagtgaccgg agctatacac
    13081 acggaaggtg cggcagcagg catccagata gggcactgcg gaaatatgtc ccataaaaag
    13141 atttgcggaa ccactcccat ttcggcctct accggtttca atctctattc tcctacattc
    13201 gtgcgtggca tgaagaaaga agagttgccg gagatggcca gagcctacgg acgggctgtc
    13261 cacttggcac gggaagccgg cttcgacgcc gtggaggtgc atgccggaca cggatatctg
    13321 atcagccagt tcctgtctcc ctacaccaat caccggaaag acgaatacgg cggctcgctc
    13381 gaaaatcgga tgcgctttat ggaagtggtg atgaacgagg tgatgacagc agcgggaagc
    13441 gatatggcgg tctttgtaaa aatgaatatg cgcgatggct tcaaaggcgg catggaaacc
    13501 gatgaaacct tgcaagtggc caaacgcctg ctggcattgg gcgcgcacgc attggtactg
    13561 agcggaggct tcgtcagcaa agccccgatg tacgtcatgc ggggagcgat gccgattcgt
    13621 tcgatggctt actacatgga ctgctggtgg ctgaaatacg gggttcggat gtttggaaag
    13681 tggatgattc cgaccgttcc tttccgggaa gcctatttcc tggaggatgc actgaaattt
    13741 cgggcggcac ttccggaagc tccgttgatt tatgtgggcg gactggtgtc ccgtgaaaag
    13801 atagatgaag tattggatgc cggcttcgat gccgtccaga tggcacgtgc gttgctcaac
    13861 gaaccggagt ttgtcaaccg gatgaggcgg gaagagcagg cacgctgtaa ctgcgggcac
    13921 agcaactact gcatcgggcg catgtacact attgaaatgg cctgccacca acatttgaaa
    13981 gaaaaactgc ctccctgcct gcaacgggag attgaaaaac tggaaaagca atgagtgaag
    14041 agaaatgggc aatcatcacc ggtgccgacg gcggcatggg aacggaaata acccgtgccg
    14101 tagccgaagc cggttaccat attattatgg cttgctatcg tccgtccaaa
//
