LOCUS       c00161_gnlPro..        11445 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|POAAMADB_161.
ACCESSION   c00161_gnlPro..
VERSION     c00161_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 07:52:43
            Original ID  :: gnl|Prokka|POAAMADB_161
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11445
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..2730
                     /locus_tag="ctg161_1"
                     /transl_table=11
                     /translation="ITRDVWLYDASTGKHTNLTNREGEDRNPVYAPDGNSVYFLSERNG
                     GSFNVYNFALNTPQEVKAITTFRTHPVRFLSISDKGTLCYTYDGELYTQEPNARPKKVN
                     VDLVHDDEKEIATLRFSQGATSASVSPDGKQVAFIVRGDVFVTSTDYATTKQITNTPAK
                     ESGVSFAPDNRTLVYASERTGNWQLYTAKIARKEEANFPNATLIEEEVLLPSKTVERAY
                     PQYSPDGKELAFIEDRSRLMVLNLKTKKVRQVTDGSTWYNTGGGFDYEWSPDGKWFTLE
                     FIGNRHDPYSDIGIVSAQGGTITNLTNSGYISGSPRWVLDGNAILFQTERYGMRAHASW
                     GSQQDVMLVFLNQDAYDRYRLSKEDFELLKEFEKEQKKAKEKDGDKKKDGSQSKKEKAD
                     KEKDKVDKEGDKEDTEKDKADKKDIVVELSGIEDRIVRLTPNSSDLGSAILSKDGENLY
                     YFSAFEEGYDLWKMNLREKGTKRLHKLNSGWSSLMLDKKGDIFLLGSRNMQKMDAKSDA
                     LKSISYQAEMKMDLAAEREAMFDHVYKQHQKRFYNLNMHGVDWNAMTAAYRKFLPHIDN
                     NYDFAELLSEWLGELNVSHTGGRYSPRGNGDVTSNLGLLSDWNYQGKGMQIAEIVEKGP
                     FDHSRTKVKAGCIIEKINGEEITPDKDITDLLNNKAGKKTLVSLYNPQNKERWEEVVKP
                     VTSGQLNGLLYKRWVKQRAEDVEKWSGGRLGYVHIQSMGDGSFRTVYSDILGKYNNCDG
                     IVIDTRFNGGGRLHEDIEILFSGQKYFTQVVRGREACDMPSRRWNKPSIMLQCEANYSN
                     AHGTPWVYKHQNIGKLVGMPVPGTMTSVSWETLQDPSLVFGIPIIGYRLPDGSYLENTQ
                     LEPDIKVANSPETIVKGEDTQLKMAVDELLKEIDSRKK"
     protocluster    1..11445
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2847:7071](+)"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2848..7071
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /neighbourhood="10000"
                     /product="Others_HGD_unassigned"
                     /protocluster_number="1"
     cand_cluster    1..11445
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D,
                     HleuD1, HleuD2, HleuS1, HleuS2, Lactoyl-CoA1,
                     Lactoyl-CoA2]) and minimum(1, [ACP_syn_III, ACP_syn_III_C,
                     AcetylCoA_hyd_C, AcetylCoA_hydro, Acyl-CoA_dh_1,
                     Acyl-CoA_dh_2, AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG,
                     Biotin_lipoyl, Carboxyl_trans, CoA_trans,
                     CoA_trans_230_acto, CoA_trans_6_Glutaconate, CoA_transf_3,
                     ECH_1, ECH_2, ETF, ETF_alpha, FGGY_C, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, Mal_decarbox_Al, Peptidase_M22,
                     Peptidase_M23, Thiolase_C, Thiolase_N, ketoacyl-synt]) and
                     not (minimum(2, [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /kind="single"
                     /product="Others_HGD_unassigned"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11445
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Others_HGD_unassigned"
                     /region_number="1"
                     /rules="(minimum(1, [HAAA1, HG2B1, HG2B2, HGD-D, HleuD1,
                     HleuD2, HleuS1, HleuS2, Lactoyl-CoA1, Lactoyl-CoA2]) and
                     minimum(1, [ACP_syn_III, ACP_syn_III_C, AcetylCoA_hyd_C,
                     AcetylCoA_hydro, Acyl-CoA_dh_1, Acyl-CoA_dh_2,
                     AdoHcyase_NAD, AlaDh_PNT_C, BcrAD_BadFG, Biotin_lipoyl,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_6_Glutaconate, CoA_transf_3, ECH_1, ECH_2, ETF,
                     ETF_alpha, FGGY_C, HCDH, HCDH_N, Hacid_dh, Hacid_dh_C,
                     Mal_decarbox_Al, Peptidase_M22, Peptidase_M23, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and not (minimum(2,
                     [AcetylCoA_hyd_C, BcrAD_BadFG, CoA_trans,
                     CoA_trans_230_acto, Mal_decarbox_Al]) and Lactoyl-CoA2 and
                     Lactoyl-CoA1) and not (minimum(4, [ACP_syn_III,
                     ACP_syn_III_C, Acyl-CoA_dh_1, Acyl-CoA_dh_2, AlaDh_PNT_C,
                     BcrAD_BadFG, ECH_1, ECH_2, ETF, ETF_alpha, HCDH, HCDH_N,
                     Hacid_dh, Hacid_dh_C, IlvN, NAD_Gly3P_dh_N, Thiolase_C,
                     Thiolase_N, ketoacyl-synt]) and HAAA1 and not HleuS1))"
                     /tool="gutsmash"
     CDS             2848..7071
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: BcrAD_BadFG"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Others_HGD_unassigned: HGD-D"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg161_2"
                     /sec_met_domain="HGD-D (E-value: 1.9e-29, bitscore: 92.0,
                     seeds: 370, tool: rule-based-clusters)"
                     /sec_met_domain="BcrAD_BadFG (E-value: 7.3e-36, bitscore:
                     112.6, seeds: 18, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKIGIDVGSTTAKLVAVDENDNLLFSKYERHNAKAKETILSFLK
                     ELLSEIGDKDISVRITGSIGMGISEKCSLPFVQEVVAAAKAIQKDYSHVTSMIDIGGED
                     AKVVFFNDAEATDLRMNGNCAGGTGAFIDQMAIILGVNIDELNQLAMNATQVYPIASRC
                     GVFCKTDIQNLIAKNVSRENIAASIFRAVAVQTVVTLAHGCDITTPVLFCGGPLTFIPA
                     LRKAFIDYLSLDEKEIILPANGTLLPALGAALFHLDKEDYCKLSHLIDKIDTTLNGNGN
                     LASTGLEPVFASNEEYEAWKERISRHKMISSGLKAGTQDVFIGIDSGSTTTKIVVLDED
                     SRLLYSYYNINGGNPIKAVEEGLNQLNDECLKQNAVLNIKGSCSTGYGEDLIRSAFQLH
                     SGIIETIAHYMAAHYLNKDVSFILDIGGQDMKVIFVNNGVIDRMEINEACSSGCGSFLE
                     TFAKSLGYSAQEFSLAACHSEAPCDLGTRCTVFMNSKVKQVLREGATINDIAAGLAYSV
                     VKNCLYKVLKLKDISVLGKDIVVQGGTMRNDAVVRAIELLSGAEVARCDTPELMGAFGC
                     ALYAMKHQGESVSLDEIINKAQYSARSLYCKSCDNRCLVIRYEFESGKSYYSGNRCEKV
                     FTNGESSNRKGLNVYRQKEELLFHRSAEIAAPEQIIGIPRCLNMYEEYPFWHTLFTSCG
                     IQVCLSDPSNFRKYEHNARMVMSDNICFPAKLVHSHVQDLIEKKVDRIFMPFVIFERKG
                     MEQNSYNCPIVTGYSEVIKSVQSEGIPVDSPAITFKDRNLLFKQCREYLSGLSVDDRTI
                     QQAFQKAESEQHSFINTLVDYNKNILQQTGKGETLTVMLAGRPYHTDSLIQHKVSDMLA
                     DMGVNVIADDLVRQMDIPTDDAHFVAQWAYTNRILKAAKWCATQGKNIQFVEMTSFGCG
                     PDAFLVDEVRDLLMRHNKSLTLLKLDDINNIGSMKLRVRSMIESLKLANADGTEDGVKD
                     FTTVPVYDKSYRDRKILVPYFTPFISPLIPAIMKVAGYDAENLPLSDNDSSEWGLKYAN
                     NEVCYPATLIVGDIIKALKSGKYDISKIAVAITQTGGQCRASNYISLIKKALVDAGYTD
                     IPVISISVGSDIDNDQPAFKVNWMKVVPITFHAVLYSDCIAKFYYASVVREKEAGASAK
                     LRDKYLQLAPEVILRRDIKGLNSLLQSAITEFNEVCRAVDTPKVGIVGEIFLKFNPFAQ
                     KEIIDWLIGRKIEVVPPILADFFMQGFVNRKVNTDSYIKNRQLPEFIYDWIYKFVKKQI
                     DKINETASKFRYFAPFNDIFEEAEGAKSVISLNAQFGEGWLLPAEIVSYARQGVNNVVS
                     LQPFGCIANHIVSRGVEKRIKSFYPDINLLSLDFDSGVSDVNITNRMLLFIDNLKNATM
                     NYDNN"
     CDS             7058..7681
                     /locus_tag="ctg161_3"
                     /transl_table=11
                     /translation="MTTTNNNEDLEKKIIEAAKELFIENGFAETSMSDIAAKVGINRPA
                     LHYYFRTKDKMFQAVFGNIILSFIPKIHDIIIQQDKPVSESIGEIVDAYYKVFTENPCL
                     PLFMVREMHRDMNHLSTTIKELRLEQYLHKIMDVLQEEMNDGRLKTVPLPFVFYTFYSA
                     LTVPFLTKNLSASFFLEKDDSFEDILVQWKPYIVRQMETLLVAS"
     CDS             complement(7689..8360)
                     /locus_tag="ctg161_4"
                     /transl_table=11
                     /translation="MGMKDVFKRYLVFVIGLYFLAAGIVLIVRSALGTTPISSVNYVLS
                     LNSPLSLGTCTFLINMLLILGQFWVIRKNKTRQDTIEILLQLPFSFIFSAFIDFNMALT
                     SNLHPDNYGMSIALLLTGCMIQSIGVVLELKPKVAMMSAEAFVKYASRRYNKEFGKFKV
                     CFDVTLVTLAVILSLLLSQCIEGVREGSLIAACITGYIVSFLNQKIMTRKTLYKLLPVL
                     K"
     CDS             8517..9407
                     /locus_tag="ctg161_5"
                     /transl_table=11
                     /translation="MVKSRIFDNRQLLKEHPEIPHYKEEVVCFMSEYKDRSYPENERYF
                     NRELYMILVLEGRSEILLNGEFIVIEPDMLLVHGANYLTDHLYSSPDIKFITLSISESM
                     RTDDSYLTQITAILLATMRQNKQYTIQLTAYESQIIRNELEVLMRLLNIKHQFLFRRIQ
                     AACNALFLDIADFLSRKTIIKKEVSRKDHVLQEFHALVTRNFREEHFVSFYADKLAISE
                     QYLARIVRAGTGKSVNTIINELLIMEARTLLSSTKSTVGDIASRLGFSDAAGFCKFFKR
                     NMGQTPLNYRKGLWI"
     CDS             complement(9494..11251)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transket_pyr"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Transketolase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg161_6"
                     /sec_met_domain="Transketolase_C (E-value: 4e-17, bitscore:
                     51.0, seeds: 80, tool: rule-based-clusters)"
                     /sec_met_domain="Transket_pyr (E-value: 8.6e-18, bitscore:
                     53.3, seeds: 81, tool: rule-based-clusters)"
                     /sec_met_domain="Transketolase_N (E-value: 2.2e-08,
                     bitscore: 22.0, seeds: 11, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYLENIYSPADVKKLSFQELNDLSHEIRASLLQKLSEHGGHFGPN
                     FGMVEATIALHYVFNSPKDKIVYDVSHQSYVHKMLTGRKDAFLHPAEYDHVSGYSEPQE
                     SEHDFFVIGHTSTSISLASGLAKGRDLTGGNENIIAVIGDGSLSGGEAFEGLDYVAELG
                     TNMIIIVNDNQMSIAENHGGLYKNLKDLRDSNGQCECNFFKAMGLDYMYVNDGNHVEAL
                     IEAFSKVKDIQHPIVVHINTLKGKGYEPAEQDKETYHWRTPFDLETGESKVNDDAEDYS
                     EVTAQYLLKKMKEDKRVVTITSGTPAVLGFTPDRRQEAGKQFVDVGIAEEHAVALASGI
                     AANGGKPVYGVYSTFIQRSYDQLSQDLCINNNPAVLLVFWGTLSGMNDVTHLCFFDIPL
                     ISNIPNMVYLAPTCKEEYLAMLEWSICQNEHPVAIRVPATDVISCGEPVESDYSNLNRY
                     KVAHRGSKVAILALGSFFGLGQSVLSLLKDKANIDATLINPRYITGVDSELMDELKADH
                     ELVITLEDGVLDGGFGEKIARYYGATDMKVLNYGAKKEFVDRYDIQELLRANHLTDEQI
                     VEDILSLIG"
ORIGIN
        1 ataacaagag acgtttggct atacgatgct tcgaccggaa aacataccaa tctgaccaat
       61 cgggaaggag aagaccgtaa tccggtatat gcaccggatg gtaattcggt ctattttcta
      121 agtgagcgca atggcggttc atttaatgta tataactttg ccctgaacac tccgcaggaa
      181 gtgaaagcca tcaccacttt ccgcacgcat ccggtacgtt tcttgtcaat cagcgataaa
      241 ggaactttat gctatacgta tgacggagaa ctttatacac aagagcccaa tgcccgcccg
      301 aagaaagtaa atgttgatct tgtgcatgat gatgaaaaag agattgctac tctcagattt
      361 tctcagggtg cgacttctgc ttctgtgtct ccggatggca agcaggtggc ttttattgtg
      421 cgaggtgatg tttttgtgac ttcaaccgat tatgctacga ccaagcaaat aacaaatact
      481 ccggcaaagg aatccggtgt atcttttgct cccgacaacc gtacactggt ttatgccagc
      541 gagcggaccg gcaactggca actttatacc gctaagatag ctcgtaaaga agaggcgaat
      601 ttccctaacg ccactcttat tgaagaggaa gtattgctcc cctctaaaac cgtagaacgt
      661 gcttacccgc aatactctcc ggatggtaag gaattggctt ttatcgaaga ccgtagccgg
      721 ttgatggtac tcaacctgaa aactaaaaaa gtacgtcagg tgacagacgg ttctacatgg
      781 tacaatacag gaggcggatt cgactacgaa tggtcgcccg atggcaagtg gtttacgctt
      841 gagtttatcg gcaatcgtca tgatccctat tcggatatcg gcattgtcag tgcgcaggga
      901 ggtactatca ctaatctgac taacagtggt tatattagcg gctctccacg ttgggtactg
      961 gatggaaatg ccattctgtt ccagaccgaa cgttatggta tgcgtgccca tgcttcctgg
     1021 ggatcacaac aggatgtgat gctggtattc ttgaatcagg atgcttacga ccgttaccgt
     1081 ttgagtaaag aggatttcga actgctcaaa gaatttgaaa aggagcagaa gaaagcaaag
     1141 gagaaagacg gtgataagaa aaaggacgga agtcagtcta aaaaggaaaa ggcagacaaa
     1201 gaaaaagata aggtagacaa agaaggagat aaggaggata ccgaaaagga caaggcagac
     1261 aagaaagata ttgttgtgga actcagcggt attgaggacc gtattgtacg cctgactcct
     1321 aactcttctg atttaggtag tgctattctt tccaaagatg gagaaaatct gtattatttc
     1381 tctgctttcg aagagggata tgacctttgg aaaatgaatc ttcgtgaaaa agggacgaag
     1441 cgtctccata aacttaattc cggctggtca tcactgatgc tggataaaaa aggagatatc
     1501 ttcttgctgg gaagcagaaa tatgcagaaa atggacgcga agtcggatgc tctgaaatct
     1561 atcagttatc aggctgaaat gaaaatggat ttggcagccg aacgtgaggc aatgttcgat
     1621 catgtatata aacaacatca aaaacgtttc tacaatctta atatgcacgg agtggactgg
     1681 aatgccatga cagctgccta tcgtaaattc ctgccacata ttgataataa ctatgacttt
     1741 gcagaattac tgagcgaatg gttaggtgaa ctgaatgttt cgcataccgg agggcgctat
     1801 tctccgaggg gcaatgggga tgtaacctct aatctgggct tattgtctga ctggaattat
     1861 cagggaaagg gtatgcagat tgctgaaatc gtagagaaag ggccgttcga tcattcccgt
     1921 accaaagtaa aggcagggtg tattatagaa aagatcaacg gggaggaaat aactccggat
     1981 aaggacatca ctgatctctt gaataataag gcaggaaaga aaacactggt ttcgctgtac
     2041 aacccgcaga ataaggaacg ttgggaagaa gtggtaaaac ctgtcacaag cggacagctt
     2101 aatggcttat tatataaacg ttgggtaaag caacgtgctg aggatgtgga gaaatggtcc
     2161 ggcggtcgtt tgggatacgt tcatattcaa tctatgggag atggcagttt ccgtactgtt
     2221 tactcggata ttctgggaaa atacaataac tgtgacggaa ttgtgatcga tacccgtttt
     2281 aacggaggcg gtcgtctgca tgaagatatt gaaattcttt tcagcggtca gaaatatttc
     2341 actcaggtgg tacgcggacg tgaagcctgt gatatgccaa gccgtcgctg gaacaagcct
     2401 tctattatgt tgcagtgtga agccaattat tcgaatgcgc atggcacccc gtgggtgtac
     2461 aagcatcaga acattggaaa actggtaggt atgcctgttc cgggaactat gacaagtgta
     2521 tcttgggaaa ctttgcagga cccttcattg gtatttggga ttcctatcat cggttatcgt
     2581 ctaccggatg gcagttatct ggaaaatact cagttggaac ctgacatcaa ggttgccaac
     2641 agcccggaga ctatagtgaa aggagaggat acgcaactta aaatggctgt ggatgaattg
     2701 cttaaagaaa tagatagtcg gaagaaatag acatcgttcg tttgtgttaa aagaaccgaa
     2761 aaaaaagctt attgaaatga tgtgtccaac ttattcttac ttttgtgttt gacaatagtg
     2821 tcaaactagg ggaacatagt gtagaacatg attaaaatag gaattgatgt aggttcaacg
     2881 acggcgaagt tagttgccgt cgatgaaaat gataatctat tattttcaaa gtacgagaga
     2941 cacaatgcga aagcaaaaga gacaattcta tcattcttga aagagctgtt atctgaaatc
     3001 ggagataaag atatttccgt gaggataaca ggctctatcg gaatgggaat ttcagagaaa
     3061 tgttcgttgc cgtttgtaca ggaggttgtt gcggcagcga aagcgataca aaaggattat
     3121 tctcatgtga cttccatgat agacatcgga ggagaagatg cgaaagtcgt cttctttaat
     3181 gatgccgaag cgaccgattt gcgtatgaac ggcaattgcg caggagggac gggtgctttt
     3241 attgaccaga tggcgattat actgggagtg aatattgatg aattgaatca actagccatg
     3301 aatgcgacac aggtatatcc tattgcctcc cgttgtggcg ttttctgtaa aacggatatt
     3361 cagaatctga tagctaaaaa tgtaagtcgt gagaatattg cggcttccat ctttcgtgcg
     3421 gtagcagttc aaacggtagt gacgctggcg cacggttgcg atattacaac tcccgtattg
     3481 ttttgtggtg gtccgttaac cttcattccg gcactgcgga aagccttcat tgattatttg
     3541 tccctcgatg aaaaagagat catactgccg gccaacggca ctttgctccc tgcactaggt
     3601 gctgctctat ttcatcttga taaagaggat tactgtaaac tgtcccattt gatcgataag
     3661 attgacacta ctttaaacgg taacggtaac cttgcctcaa caggattgga acctgttttt
     3721 gcaagtaatg aagaatatga agcatggaaa gaaagaatat cccgtcataa gatgatatct
     3781 tccggcttga aagccggaac acaggatgtc tttatcggca tcgattcagg ttctactacg
     3841 acaaagattg ttgtactgga tgaagattca aggcttctgt attcttatta taatattaat
     3901 ggcggcaatc cgataaaagc tgtggaagag gggctgaatc agttgaacga tgaatgtttg
     3961 aagcagaatg ccgtactcaa tataaaagga agctgttcta ccggatatgg ggaagacctt
     4021 atcaggtctg cctttcagct tcattcgggg attatcgaaa cgatcgccca ttatatggca
     4081 gcgcattatc tgaacaagga tgtgtctttt atcctcgata tcggcggaca ggatatgaag
     4141 gttatttttg tgaataatgg cgtgattgac cggatggaga ttaatgaagc atgctcttcc
     4201 ggatgtggtt cttttcttga aacgtttgct aaatctctgg ggtattcggc acaagagttt
     4261 tctctggcag cctgccattc ggaagcaccg tgtgatttgg gaacaaggtg caccgttttt
     4321 atgaactcaa aagtgaaaca ggtactcagg gagggggcaa cgatcaatga tattgccgcc
     4381 ggactggcat attccgttgt caagaattgc ctgtataagg tgttgaaact gaaagatata
     4441 tctgttttgg gaaaagatat tgttgtgcag ggaggcacca tgcgcaatga tgcggtggtc
     4501 cgtgccattg aacttctctc gggagcggaa gtggcaaggt gtgatacacc cgaattgatg
     4561 ggagcattcg gatgtgcatt atatgcgatg aaacatcagg gggagtccgt atcattggat
     4621 gagattatca ataaagctca atattcggca cgttctttat attgcaagag ttgcgataat
     4681 cgttgtctgg tcattcgtta cgagttcgaa agcggcaaaa gttattattc gggaaacagg
     4741 tgcgagaaag ttttcacgaa tggagagagc agtaaccgga aaggtctgaa tgtctatcgg
     4801 caaaaagaag agcttttgtt tcatcgcagc gcagagattg cagcacccga gcagattatc
     4861 ggaatccccc gatgtctgaa tatgtacgag gaatatccat tctggcacac tcttttcact
     4921 tcctgtggca tacaagtctg tttgtctgat ccgtccaatt tcagaaagta tgagcacaat
     4981 gcgcgtatgg tgatgtcgga caatatctgc tttccggcta agctggtaca tagtcatgtt
     5041 caggacttga tagaaaagaa ggtcgaccgg atttttatgc cttttgttat tttcgaaaga
     5101 aaagggatgg aacaaaacag ttataattgt ccgattgtga caggttattc ggaggttatc
     5161 aaaagtgtgc agtccgaagg tataccggtt gattcccctg caataacttt caaagaccgg
     5221 aatctgttgt ttaaacaatg ccgtgaatat ctgagcggtt tgagcgtgga cgatcggacg
     5281 attcagcaag cattccaaaa agcggaaagc gaacagcact cttttattaa tacattggtc
     5341 gattataaca aaaacatatt gcagcagact ggaaagggag agactttgac tgtcatgctt
     5401 gccggacgtc cttatcatac cgattctctg atacagcaca aagtctcgga tatgcttgcg
     5461 gatatgggag tgaatgtgat agcggatgat ttggtgcgtc agatggatat accgacggat
     5521 gatgcgcatt ttgttgctca atgggcgtat acgaaccgta tcctgaaggc tgcgaaatgg
     5581 tgtgcgacac aaggaaagaa tattcagttt gtagagatga cttcgttcgg atgtggaccg
     5641 gatgcttttc tggtggatga agtaagggat ttgctgatgc gtcataacaa atcgctgacc
     5701 ttattgaaac tggatgatat caataatatc ggttcaatga agttgagagt acgttccatg
     5761 attgaaagcc tcaaacttgc gaatgcggat ggaacggaag acggtgtaaa ggactttacg
     5821 accgttcctg tttatgacaa gtcttaccgt gaccgtaaga tactcgttcc ttactttact
     5881 ccgtttattt cacctttgat tcctgctatt atgaaagtag ccggttatga tgcggaaaac
     5941 cttcctctca gtgataatga ttcaagtgaa tgggggttga agtatgcgaa taatgaggtc
     6001 tgttatccgg ctactctgat agtcggcgat attataaaag cacttaaaag cgggaaatat
     6061 gatatttcaa aaatagccgt agccatcacc caaacgggag gacaatgccg tgccagcaac
     6121 tatatttcct tgataaaaaa ggcgttggtg gatgccggat atacggatat tccggtaatc
     6181 tctatctctg tgggcagtga catagataat gaccagcccg cgttcaaggt caactggatg
     6241 aaagtagtac cgataacttt tcatgccgtt ttgtatagtg attgcattgc taagttttat
     6301 tatgcgtctg tggtacgtga gaaagaagca ggtgcatcgg caaagctgcg tgataaatac
     6361 ctgcaactgg cacctgaagt gatactgaga agagacataa aggggttgaa ctctttgttg
     6421 caatcggcaa tcactgaatt taatgaggta tgtagggctg tagatactcc taaagtcgga
     6481 attgtaggag aaatcttctt gaaattcaat cctttcgcac aaaaagagat cattgattgg
     6541 ctgataggcc gcaagataga agtggttccg ccgattctgg ctgacttttt catgcagggg
     6601 tttgtgaaca ggaaagtcaa tacggattct tacataaaaa acagacagtt gcctgagttt
     6661 atttacgact ggatctacaa gtttgtaaag aaacagattg ataaaataaa tgagacagca
     6721 agtaagttcc gttactttgc ccccttcaat gatatctttg aagaagcgga aggagctaaa
     6781 agcgttattt cgctgaatgc ccaattcggt gaaggctggt tgttgccggc tgaaatcgtg
     6841 tcttacgccc ggcaaggggt gaacaatgta gtgagtttgc aaccttttgg ctgcatagcg
     6901 aatcatatcg tatccagagg agtcgaaaaa cgtataaaaa gtttctatcc ggatataaat
     6961 ttgctatctt tagactttga tagtggtgtg agcgacgtaa acataacaaa ccgtatgctt
     7021 ttgtttattg ataatctgaa aaatgcgaca atgaattatg acaacaacta ataataatga
     7081 agatttggag aaaaagataa ttgaggctgc caaagaacta tttatagaga atgggttcgc
     7141 agaaaccagt atgagtgata tcgctgctaa agtaggtatc aacagaccgg cacttcacta
     7201 ttatttccga acgaaggata agatgtttca ggccgttttt ggtaatatca tactttcttt
     7261 tattcccaaa atacatgata taatcattca gcaggacaaa cctgtctccg agagtatcgg
     7321 tgaaattgta gatgcttatt ataaagtatt cacggaaaat ccatgtttgc cattgttcat
     7381 ggtgagggag atgcatcgtg atatgaacca tttaagcact actatcaagg agttgcgcct
     7441 ggaacaatat ctccataaaa tcatggatgt tttacaggaa gaaatgaatg acgggagact
     7501 gaaaacagtt cctttgccat tcgtattcta tactttttat agtgcattga cagttccttt
     7561 cctgacaaag aatctcagtg cttctttctt tttggagaag gatgattctt ttgaggatat
     7621 tctggttcag tggaaacctt atatcgtcag gcagatggaa acgttgctgg tagcgagcta
     7681 gagaaaactt atttcaatac aggtaataat ttgtagagag ttttccttgt cattattttc
     7741 tgattcagga agctgacgat atatccggtg atgcaggcgg cgataagaga cccctcgcga
     7801 acaccttcga tgcattgcga aagcaggaga gagagtatga ctgccagagt gaccagcgta
     7861 acatcaaaac agactttgaa ctttccgaac tctttgttat aacggcggga ggcgtatttt
     7921 acaaaagcct ctgcactcat cattgctact ttgggtttga gttcgagtac gactcctatg
     7981 gattgtatca tgcatcctgt gagtaataag gctattgaca ttccgtaatt gtcgggatgc
     8041 agattactgg tgagtgccat attaaaatca atgaatgccg aaaagataaa agagaacggc
     8101 aattgaagaa gtatttcaat agtgtcctgt cgggtcttat tttttctgat gacccagaac
     8161 tgtcccagaa taagcagcat attgatcaga aacgtacaag ttcctaatga taaagggctg
     8221 ttcaggctta gcacataatt gacgctggat ataggtgtgg ttcctaatgc agaacgcaca
     8281 atcaacacta ttccggcagc cagaaaatac aatccgataa caaataccaa atacctttta
     8341 aaaacgtctt tcattcccat atcttactat cttatataat cgtatttttc ttcattctat
     8401 aaagaagaat atgcaaaggt cccgtttttt cgtctgatat aagttatccg attccacaca
     8461 gtttttgtca tatccgaaac aaattgtact tttacgtcga aaagaaggag gtataaatgg
     8521 taaaatctcg tatttttgat aataggcagt tgttaaagga acatccggaa attcctcatt
     8581 ataaagagga agtagtctgc tttatgagtg aatataagga caggagctat ccggaaaacg
     8641 aacgttactt taatcgtgaa ctttatatga tactcgttct tgaaggtcgt tccgagattt
     8701 tgctgaatgg ggaatttatt gtgatagagc ctgatatgtt gcttgttcat ggagcgaatt
     8761 atctcaccga ccatctttat tcgagtccgg atattaagtt tatcaccctc tccatttccg
     8821 agtccatgcg gacggatgac tcttatctta cccagataac ggctattctg ttggcaacga
     8881 tgaggcagaa taagcaatat accatacagc tgaccgcata cgaatctcaa atcattcgta
     8941 atgaactgga agtgttgatg cgtttgctga atataaaaca tcagtttctt ttccggcgaa
     9001 tacaggcggc ttgcaatgcc ttatttttgg atatagccga ttttctttcc cgaaagacta
     9061 tcataaaaaa ggaggtcagt cgtaaagacc atgttttaca ggaatttcat gcgcttgtta
     9121 cccgaaattt cagagaagag catttcgtta gtttctatgc ggataagctg gccatcagtg
     9181 agcagtacct tgcacgtatc gttcgtgccg gaacgggaaa aagtgtgaat acgattatta
     9241 atgagttact gatcatggaa gcccgtacct tgctgagttc cactaaatct acggtagggg
     9301 atattgcttc ccggcttggc tttagtgatg ctgccggttt ctgtaagttt ttcaagagga
     9361 atatggggca gactcctctc aattatcgga agggattatg gatttaagtg aaaatgaatg
     9421 taggttgatg tgatcccata acgaacggat acatcaacct acatgaaata tataatgaac
     9481 tggttttgac ttatcagcca atgagtgata ggatatcttc tacgatctgt tcatccgtca
     9541 gatggttggc acgaagcagt tcctgtatat cataacggtc tacaaattct tttttagctc
     9601 cgtagttgag tactttcata tctgtagcgc catagtaacg ggcaatcttt tcaccgaaac
     9661 caccatccag aactccgtct tccagggtaa tcactaattc gtggtcggct ttcagttcgt
     9721 ccatcagttc gctgtccaca cctgtgatgt agcggggatt gataagggtg gcatcaatgt
     9781 tggctttatc tttcagcaat gacagaaccg attgccctaa tccgaagaag gagcctaatg
     9841 caagaattgc tactttggag ccgcggtggg cgactttata acgattgaga ttgctatagt
     9901 cggattccac cggttcaccg caactgatta catctgtggc aggtacacgg atagccaccg
     9961 gatgctcatt ttggcagatg ctccattcca gcatggctag atattcctct ttacaggtag
    10021 gtgccagata gaccatattg gggatattgc tgataagtgg aatatcgaag aaacagaggt
    10081 gggttacatc attcataccg gataacgtcc cccagaatac caacagaaca gccggattat
    10141 tattgataca gagatcttgc gatagctggt cgtaagagcg ttgtataaag gtgctgtaca
    10201 ctccgtaaac cggttttccg ccattggctg cgataccgga agcaagtgcc actgcatgct
    10261 cttcggcaat accgacatct acaaactgct tgcctgcttc ctgacgacgg tcgggagtga
    10321 agcctagaac agcgggggtg cccgaagtaa tggtaactac acgcttgtct tctttcatct
    10381 tttttagcag atattgagcg gttacttcac tataatcttc tgcgtcgtcg ttcacttttg
    10441 attctccggt ttctagatca aacggagtgc gccagtgata ggtctccttg tcctgttctg
    10501 caggctcgta acctttgcct tttaatgtat tgatgtggac tactatcgga tgctgtatat
    10561 ctttaacttt ggagaaagcc tcgatcagtg cttccacatg gttgccgtca ttcacgtaca
    10621 tatagtccag ccccatcgct ttgaagaagt tgcattcaca ttgaccgtta ctgtcgcgca
    10681 aatctttcag attcttgtat aaacctccgt gattttcggc aatggacatc tgattgtcat
    10741 tgacaataat aatcatgtta gttccgagtt ctgctacgta gtccagtccc tcgaaggctt
    10801 cgcctccgct tagtgaaccg tcgcctatta cagcgatgat attttcgttg ccacctgtca
    10861 ggtcacgtcc ttttgccagt ccgcttgcca agctgatcga agtagaagta tgaccgatca
    10921 caaagaaatc atgttcactt tcctgtggtt ctgagtagcc ggatacatgg tcatattcag
    10981 caggatggag aaaagcatct ttacgtccgg tcagcatctt atgtacgtaa ctctgatgtg
    11041 atacatcata tacaatttta tctttcggtg aattgaaaac atagtgcagg gcaatggtcg
    11101 cttctaccat tccgaagtta gggccgaagt gcccgccatg ttcactcagt ttttgtaaga
    11161 gggatgcacg gatttcgtga cttaaatcat tcagttcctg aaacgataac ttctttacgt
    11221 ctgcgggaga gtaaatattt tctaaataca tatcaaattg ttttttatgt ttatacctat
    11281 atttttattt cactgcaaag atactgccgg atttgaaatc tgtttgtata tgaattacgg
    11341 attcttttac ctatattaca gttccgctaa aaatgggctt gataaaacat aaaatatgac
    11401 ttcctctata tcaaccatat gctcttttgc aagcttgatt ctttt
//
