LOCUS       c00005_gnlPro..        16143 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OECBMEKJ_5.
ACCESSION   c00005_gnlPro..
VERSION     c00005_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 05:41:24
            Original ID  :: gnl|Prokka|OECBMEKJ_5
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 52487
            Orig. end    :: 68630
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16143
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[62487:65952]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13465
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..16143
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16143
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             1095..1613
                     /locus_tag="ctg5_53"
                     /transl_table=11
                     /translation="MKKYWHIALMLFCVLMITSCGDDDEALEVDEVWKVQNEEAFQAQM
                     LVPGFEQLSSQSNAGFILYKVLKTGESKEPIYYTSKVECYYKGTFIDGTVFDDKSFEAG
                     APAELTVSDMVDGFATALQNMHPGDRWEIWIPQQMGYGAAGRSASGSVIIKPYTTLIFD
                     LEVTRIVKE"
     CDS             complement(1950..2744)
                     /locus_tag="ctg5_54"
                     /transl_table=11
                     /translation="MQEHPITTSILHKGQGSLLLLLAIAIQCALLTLYGDLPLSITLVD
                     SLLSIALFAVAGYYLWYVQCTLHIMQARVAFAVLVQIACIAGCSILLQIFGLEDWEEFS
                     ITIPFRFLFGLMAWIILSQWYASRERKSEAEPIVRQMEEKTAPPPTTVPEEILDRISVK
                     DGTRIHIIPIKEIFYLQACGDYVTLFTTSGQHVKEQTMKYFERSLPSPEFVRIHRSYIV
                     NTEQILRVELFGKETYQVRLKDGTYLRASSAGYKLLKERLSL"
     CDS             complement(2752..3519)
                     /locus_tag="ctg5_55"
                     /transl_table=11
                     /translation="MDMKDYDIDFKEKRTNGYLIATLFIIVGILFLLRNLGMIDPSLFD
                     LLVSWPMLLVVSGIFTIFHRNPVGGMLLVGVGVYFLFPQLNWITNDFLRVYWPLGLILL
                     GLVIMLKRKDSIRTKKHKRPFNHPPFGHRKPNDEINYETDNGFVSVDTTFNSVRHIVLD
                     PVFKGADIDVSFGNVILDLKKTTLEADETIINIDSSFSGVVIYVPKGWLVRLKVDSFLA
                     GCQDMRDLTETTDMTHTLYICGDLSFSGLELRD"
     CDS             3758..6895
                     /locus_tag="ctg5_56"
                     /transl_table=11
                     /translation="MIRNIINLKAIILYFGLILCLIAGMLTPAYGSFSYPVKDESYVLV
                     INSYVDGERWSGNLLNMISKFATPEEYTLRIDHMSVMLVDTPEKLKEKQEAFFEVNKKK
                     PDGIIYLGVNGWAFMRDKIREKWGDIPTLVCSETGEMAEDECYFNQRHSSDRVIPLQEA
                     VKGYNATGLVIPYYVKGSIDLVKELIPGLRRLIFISDRRYVSTWLRDEMEKHMETSFPE
                     GKVDFYTEGSCSMDSLMAVLSEKDPHRATAVMYYSWITEKPFLNHSLLYSTLYQGINGI
                     SRHPVFSLYDMGVEEGYTIGGYYNSAKTIETALIPLLQQVYNGEDMGKIPVSTVNDPHK
                     YLNYASLISAISNEDNFPRDAIYLNAPPSFLEKYWMQLLGFLIFFLVVVFLAGHYVYRS
                     KQKMKEVELRLLSRYRDLFNNMPLPYIRQRLIREGTQIDVQVLDVNHAFEEKIAPKDFV
                     VNKRGKEIANLIGGSYPLLLSAVPTVLESGKSFTYEYYFEPTGLYYTIIIMPTSEENVV
                     DAFFIDITDIHKFQTHLKAMNHKLAMALEAADLLPWRYNLAEGKIIYESKVHPEDNIET
                     AEIHTHEVSLEEYFSKIHPSFRACVEKAFDDLCNGKIKKVRKEYCLERLIPGEDRHEWE
                     EIQVMAEYDASGKPKALIGSTISITERKQLEHDLRMARDKAEESNKLKSAFLANMSHEI
                     RTPLNAIVGFSNILASTDDLEDKKEFADIIENNNSLLLQLINDILDLSKIEAGTLEFTY
                     DYVDINAVLRDLEQSAHLKNKNPDVQISFKDYLEPCVIYTDRNRLSQLMINLLNNAMKF
                     TQAGSILFGYKLKDDNTLWFYVEDTGCGIPENKRKDIFGRFVKLNTFAQGTGLGLSICE
                     MIVTQMKGMIGVDSVEGKGSRFWFTLPFQPKKELLPSEEPKPVTLDKIARNELTILIAE
                     DNSSNYRLFESILKPEYKLIHAWNGKEAVELFHRHKPQLILMDIKMPVMDGYEATAEIR
                     KVSSNVPIIAVTAYAFAQDEQRIIKSGFDAYTAKPINGKVLKDKISTLLTHRIILM"
     CDS             6994..7086
                     /locus_tag="ctg5_57"
                     /transl_table=11
                     /translation="MKKPRCKYTELPLFVNRLSAKLCFVTCNKI"
     CDS             complement(7101..8333)
                     /locus_tag="ctg5_58"
                     /transl_table=11
                     /translation="MKILLVTRGSQGDVLPYLAIAAELERRGHEVTINLPQIFEETVKP
                     YGFKYVLQQFDDIGGMIDSAAQNSHKFRPFLKWMRNVIDKQFDQLIPLLKEHDILVSTN
                     SEFAVASIAEYCKKPLIRTAYAPFLPGKKIPPAVLPFPKPNPIITPAILWKLMNRMTNF
                     MVKDTINKNRAKYGLAPIRNFGYHAGERSYNYLLFSQHLGNVDPDWTFEWSIGGYCFND
                     TFQYDEKAYEEMISFVDSAQSPIIFFTLGSCSSKDGNRFSKALVDICKKHDYRLIIGSG
                     WAKTGITLQADKHLFLMKQPVPHNLIFPHCDGVIHHGGCGTTHSVGRAGKPQLITPLII
                     DQPYWSYRIHQLGLGPEGVKIAKASEQEIERKVCDLVTNPLYKKNAAHIGEMIQKEGGI
                     KNICDSIERFQ"
     CDS             complement(8367..9578)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg5_59"
                     /sec_met_domain="Radical_SAM (E-value: 5.8e-16, bitscore:
                     51.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKRTTSSFRAMSTERKLESIFLFVTGRCNAKCAMCFYAQEMDK
                     KQPDLTFDEIKKISETAGQFNRLWISGGEPTLREDLPEILELFYKNNHIKDVNIPTNGL
                     KPDRIVEWVKRFRQNCPDCNINVSLSLDGFGTTHDTQRGVPGNFYKALETLRKIQENFG
                     DDGKVLKNIATVITKYNIDQVEDFMTWVYGRFRTSTHTIEAARGMTRDDGVKILTESTL
                     RKIQDDISPIYSAYADRMVADTTGLRKPITRFFYLGLIRTLYNIRASNIDHPTPWGMDC
                     TAGETTLVIDYDGRFRACELREPLGNIKEYGCDISKVMNSEAMKQEIAAIGHGYKANCW
                     CTHGCWITSSVIFNPRKMIRSVYKGYRETKRLNHPLAINEQKLQTMEAKYHLDIERLRQ
                     LNIR"
     CDS             complement(10001..10756)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_60"
                     /sec_met_domain="Fer2_3 (E-value: 4.1e-25, bitscore: 80.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 1.4e-11, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.5e-05, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDINITLKVWRQKGPNVKGQFETYQLKNINQGTSFLEMLDILN
                     EQLISEGKEPVVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFTSVNTGGVPDANAIPIPKPDAEMAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFICAKLQD"
     CDS             complement(10781..12724)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 197.2; E-value:
                     1.7e-60)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_61"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.8e-60, bitscore:
                     197.2, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 4.6e-38,
                     bitscore: 122.2, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVHGDYQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNNTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFNEAEKNIQARINKLMSIKGKESVDSIHKRLGHI
                     MWEHIGMARNAESLKEAIQMLKDLKKEFWSNVFIPGNADDLNVELEKALRLADFIEIGT
                     LMAHDALDRAESCGGHFREEHQTEEGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     EFVVPQTRNYKK"
     CDS             complement(12773..13465)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg5_62"
                     /sec_met_domain="SucD_FumR (E-value: 6.5e-74, bitscore:
                     239.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLVLFLLFHLSMNVAAVFSGEAYNMV
                     CSLLGSNWYAVAATLVLAAGVVIHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGLIVILFMLLHFSQFWYKMMFAELIGHHEVALGSAMVSPQDGAAFINYYFQGNAV
                     ITVLYLIWYVALWFHLTHGFWSAIQTIGWNNTIWMNRWECISKIVATVICGLFAIITII
                     FFLNGVGA"
     CDS             13588..15066
                     /locus_tag="ctg5_63"
                     /transl_table=11
                     /translation="MGEVRACAPTHEIMRKEKAFLMNNLYTFAYMRKDLNGPRHFSIGV
                     KFTILLFTIAILVLVLFSYRSDKHGNLFWQVEKLIPHHPDSALVLLEKVTDINGLSLRE
                     KARYCLLWTESRDEAGLRHTSDSIISIATDYYRTTRGCYWPPKAWFYRGKVYEDMDQPS
                     LALECYLRALEYEGGNWDYEFWGRLYNQIGRLYAEQELYSKAMSFLRKASAQYQLLNDT
                     AGQGRILEEVKKYEALRDSIGSLSARESIYQITSRYDVRPVREDLYRKELMLSQRGQER
                     YLYAFIIGIILFICFLLYRRWRDTQENALRREEALRRSIASQQQRMREEKEENERQIAL
                     LEKRITKIKEEKDQELMLVSLQLEKQRLEICNESIHNKESKHLLSVAILRKSEVYEKFH
                     DRDADKIVSEDWELLEVLLNKAYDDFTLRLKKLYPAISDTELKVCMLTKIGVPANQITR
                     VLKYNSSVLRPRLFRKIFKKEGSTEAFVEFISSF"
     CDS             15176..16141
                     /locus_tag="ctg5_64"
                     /transl_table=11
                     /translation="MKSVKLASILFYLNSVFVVSCFVSCGSSPTEAPSLLTADIRGGMD
                     KPRLLGLGDEIKGVTFVPLEVTTDDASLIDGVYDYAVTDRYIYVLPVKEPRIVLFDRQG
                     RFIRTLVKEGQGPGEFSGILPCIQVDERNDRLFLFSNNRVWEYTLEGEFIGQSTHEYSV
                     IYMRHIGKDRFAAISFPFQPFNGGGFGLGLFSRKGDTIAIKNDFYSFLLPHEKSGFTTS
                     IAPAYSDAQNSVLFKTGSNDTVFSISADRISAACVLDLKNSDAEVIRSLDVTDMSICEL
                     KKKAPKDIFVQDMIEFPEHYYFRLLYNQGYYIASVDKKTGK"
ORIGIN
        1 gatccatgag cgttatagca aggcgatgaa cgagtctaac ttcgaggatc ttcgccaatt
       61 gatcttggat tgcgagatcg tttgcccgat ttccggaact cgtaactgga cggaggttcg
      121 ccagtttaac ttgatgttct ctacggatat gggttctact gctgatggag cgactaagat
      181 ttatcttcgt ccggagacgg cccaaggtat tttcgtgaac ttcttgaatg tgcagaagac
      241 aggccgtatg aagatcccgt tcggtatcgc ccagatcggt aaggcgttcc gtaatgagat
      301 cgtggctcgc cagtttatct tccgtatgcg tgagttcgag caaatggaga tgcaattctt
      361 cgttcgtccg ggtgaggaga tcgagtggtt taagaaatgg aagtctactc gtttgaaatg
      421 gcatcaagcc ctaggtttgg gcgatgagaa gtatcgctat cacgatcatg agaaattggc
      481 tcactacgct aacgcggcta cggatatcga gttcgagatg ccattcggat ttaaggaagt
      541 ggagggtata catagccgta cgaacttcga cttgagtcag catgagaagt tttccggtaa
      601 aaagatccaa tatttcgatc cggagttgaa ccagagttac actccgtatg taatcgagac
      661 ctcgatcggt gtagaccgtg tgttcttgag catcatggcg ggttcttact gcgaggagac
      721 gttggcgaat ggcgagagcc gtgtggtatt gaagttgccc gcagccttgg ctccgatcaa
      781 attggccgta ttgccattgg tgaagaaaga tggcctgccc gagaaagctg aggagattat
      841 aaatatgttg cgtttcgact tccgttgcca atacgacgag aaggattcta ttggtaagcg
      901 ttatcgccgt caggatgcga tcggtacccc gtattgtatt acggtagacc atgacacctt
      961 gaaggataac tgcgtaacga tccgtttccg tgacacgatg gagcaagagc gcataagcat
     1021 cgataagctt cacgatatta tcacggagaa ggtgagcatg aagaatttat tgaaaaaggt
     1081 aatagagtaa acgaatgaag aagtactggc atattgcgtt gatgttgttt tgcgtgctca
     1141 tgatcacctc ttgtggggat gatgatgagg cactagaggt ggatgaggtt tggaaggtcc
     1201 agaatgagga ggcttttcaa gcccagatgc tggttccggg tttcgagcaa ttgagttctc
     1261 aaagtaatgc cggatttatc ctttacaagg tcttgaagac tggggagagt aaggagccga
     1321 tttattatac gagcaaggtg gaatgttatt ataaagggac gtttattgat gggacggttt
     1381 ttgatgataa atcgtttgag gctggtgccc ctgccgagct tactgtttct gatatggtag
     1441 atggttttgc tacagcgtta cagaatatgc acccaggaga tcgttgggag atttggattc
     1501 ctcaacagat gggatacggt gcggctggaa ggagtgcttc gggaagtgtc ataataaagc
     1561 cttatacgac tttgatcttt gatttggaag ttacaaggat tgtcaaagag taggttcttt
     1621 cattaagaat aattacggcc gcctcttttt aggggtggcc gtttttataa ttatatgtaa
     1681 atctagggaa gcaaatcccc tataaacaat taaagcctgt ctcacgacaa gccctaacca
     1741 aactttgtta accttaaatc taatactatt atgaaaaaac cacgatgcaa agatacgttc
     1801 gtcaagacca tttgtcaagt cttttgcaac taatatatgt taagtaacat atcgatgctt
     1861 gccaaaaagt gttacacaac ataaaactct atatattaca atcaaaatct tctaatttta
     1921 acgatgatta ggtccctttt ataggactgc taaagggaaa gacgttcttt gagtagctta
     1981 tagccagcgc tactggcacg aagataggtt ccatccttta atcgtacttg ataggtttct
     2041 tttccgaata gttctactcg caatatctgt tccgtattaa cgatataaga gcgatgtata
     2101 cgaacgaact ccggagaagg aaggcttcgc tcgaaatact tcatggtttg ctcctttacg
     2161 tgctgaccgg aagtagtgaa taaggtcaca tagtcgccac atgcttgtaa atagaatatc
     2221 tcttttatcg ggatgatatg aatacgtgtc ccgtctttta cggatatacg atctagaatc
     2281 tcctccggaa cagtagtcgg gggaggtgcc gtcttttcct ccatttgtct cacgataggt
     2341 tccgcctcac tctttctttc ccggctggca taccattggg atagaatgat ccatgccatt
     2401 aggccgaaca ggaatcgaaa aggaatcgtg atcgagaatt cctcccaatc ttccaatccg
     2461 aatatttgta gcaagatcga gcatccggct atgcaagcga tttgtacgag tacggcgaaa
     2521 gccactcgtg cttgcatgat atgtaacgta cattgtacat accaaagata atatcccgct
     2581 acggcgaaca atgcgatgga aagtaagcta tcgaccaaag tgatgctcaa cggaagatcg
     2641 ccataaagag ttaataatgc gcattggatc gctatggcta aaagtaataa taggcttccc
     2701 tgccctttat gtaatatgga tgttgtaata ggatgttctt gcatgatgag tttagtctct
     2761 tagttcaagg ccgctgaacg acaagtctcc acatatatac aacgtgtgcg tcatgtcggt
     2821 tgtttctgtc aggtccctca tatcttggca tccagccaag aaggaatcaa cctttagacg
     2881 aaccagccat cctttaggga catatattac tacgccgctg aaggagctat ctatgtttat
     2941 gatggtttca tcagcctcta atgttgtttt tttaagatcg aggatcacgt tgccgaaaga
     3001 tacgtctatg tccgccccct tgaatacggg gtccagtacg atgtgcctta ccgagttgaa
     3061 agtggtgtca accgatacga aaccgttatc tgtctcgtag ttgatctcat cgttaggctt
     3121 tcggtgcccg aaagggggat ggttaaaagg acgtttatgc tttttcgtgc ggatagaatc
     3181 tttccgcttc agcatgatga ccaatcctaa caggattaat cctaacggcc aatatacacg
     3241 taagaaatcg ttcgtgatcc aatttaactg cgggaaaagg aaatagactc ccacgcccac
     3301 gaggagcata cctcctaccg gattacggtg gaaaatcgta aagatgcccg acacgacaag
     3361 cagcatcggc caagatacaa gcaagtcaaa taaggatgga tctatcattc ctagattccg
     3421 cagtaaaaat aatataccga caatgataaa taaggtagcg atcagatacc cgtttgtcct
     3481 cttctcttta aaatcgatgt cataatcttt catatccata agttccattt tttgtttttt
     3541 atcaaatgta cgggttcgtc attctataca caagtaaata ccgctgattt ctatacgagt
     3601 atcggtaaat aaccgaataa tcccgattaa aaaagccttt agtttgtaag aaacgtgaat
     3661 ttgacaccaa aacttgataa aaaaactagt ttgataagat tagttgataa ttaaggaata
     3721 tctttgtctt tacaactgca atagaggaat gtagggaatg atacgaaata ttataaattt
     3781 aaaggcaata atactttatt ttggattgat tttatgcttg atagccggta tgctgactcc
     3841 ggcttatggg agtttttcat atccggtcaa ggatgaatcg tatgtattgg taataaattc
     3901 atatgtggat ggcgaacgct ggtctggtaa tttattaaac atgatctcga agttcgctac
     3961 cccggaggag tacaccctcc ggatagatca tatgagcgtg atgttggttg atacgccaga
     4021 gaaattaaaa gagaagcaag aggccttctt tgaagttaat aagaagaagc cggatggaat
     4081 tatctactta ggcgtaaatg gatgggcttt tatgcgggat aagatccggg agaaatgggg
     4141 ggatattccc actctggtct gttcggaaac gggtgaaatg gcagaagatg aatgttattt
     4201 taatcagcgg cattcctctg atagggtgat ccctttacaa gaggcggtta aggggtataa
     4261 cgctacgggc ttggttatcc cttattatgt taaaggttcg atcgacttgg ttaaggaatt
     4321 aatcccgggt ttgagacgtc tgattttcat atccgacaga cgttatgttt ccacatggct
     4381 tcgggatgag atggagaaac atatggaaac ttctttccct gaggggaaag tggattttta
     4441 tacggagggt tcttgctcca tggatagttt aatggcggtt ctgtcggaga aagacccaca
     4501 tcgagcgacg gccgtgatgt attactcgtg gattaccgag aagcctttct tgaatcactc
     4561 gttattatat agtactttgt atcaaggtat aaacggcatt tctaggcatc ctgttttttc
     4621 tttatatgat atgggcgtgg aagaaggata tacgattggt ggatattata atagtgctaa
     4681 aacgattgag actgctctaa tccccttgct acaacaagtt tataacggtg aagatatggg
     4741 caagatcccg gtttcgacgg taaatgatcc tcataaatac ttgaattatg cttcgttgat
     4801 aagtgcgata tctaatgaag ataatttccc gcgtgatgcg atctatttga atgcgcctcc
     4861 ctctttcttg gaaaaatatt ggatgcagct gttaggcttt ctgatattct ttctggtagt
     4921 agtgttttta gcggggcatt atgtgtatcg ttctaaacaa aagatgaagg aagtagagtt
     4981 gaggttgttg tcccgttacc gtgatttatt taataatatg ccgttacctt atatacggca
     5041 gcggctgatt cgggaaggta cgcaaatcga tgtgcaggtt ttagatgtga accatgcttt
     5101 cgaggagaaa atcgctccta aagattttgt ggtaaataag cgtggaaaag agatcgcaaa
     5161 tttgattggc gggagttatc ctttgctcct atcggcagtg cctacggttt tagagagtgg
     5221 aaaatccttc acttatgagt attattttga gccgacaggg ctttactata cgattatcat
     5281 catgcctacc tcggaagaga atgtagttga cgcgtttttt attgatatta cggatatcca
     5341 taaattccag acgcatttga aagccatgaa tcataagctg gccatggcgc tagaggcggc
     5401 agatcttttg ccgtggcgat ataatctggc tgaagggaag attatctatg agtcgaaagt
     5461 acatccggaa gataatatag agactgccga gatacatacc catgaggttt cgttggagga
     5521 atatttcagc aagatacacc cgtctttcag ggcttgcgtg gaaaaggctt tcgatgattt
     5581 gtgtaatggg aaaataaaga aagtacgaaa agaatattgt ctggagcggt tgattccggg
     5641 agaagatcgc catgagtggg aggagataca ggtaatggcc gaatatgatg cttccggtaa
     5701 accgaaagcg ttgatcgggt ctacgatatc tattaccgag cgtaagcaat tggaacatga
     5761 ccttcgaatg gctagggata aggcggagga gtcgaataaa ttgaaatcag cgtttttagc
     5821 aaatatgagc catgagatac gtacaccgtt aaatgcgatc gtaggtttct ctaatatcct
     5881 tgcctcgacc gatgaccttg aggataagaa ggaattcgct gatattatcg agaataataa
     5941 ttccctattg ttgcagttga taaacgatat cttggattta tcaaagatcg aggcgggtac
     6001 cttggagttt acttatgact atgtggatat taacgctgta ttgagggatt tggagcaatc
     6061 ggctcatttg aagaataaga atccggatgt acagatctca tttaaggatt atctggagcc
     6121 ttgcgtgatt tatacggatc gaaatcgtct gtctcaactg atgatcaatc tgttgaacaa
     6181 tgccatgaaa tttacgcagg caggatcgat tttatttggc tataagttga aggatgataa
     6241 tacgttgtgg ttctatgtag aggatacggg ctgcggaatc ccggagaata aacggaaaga
     6301 tattttcgga cgttttgtga aactgaatac tttcgctcaa ggaacaggat tgggtttaag
     6361 catctgtgag atgattgtta cccagatgaa aggaatgata ggggttgatt ccgtggaagg
     6421 gaaaggctct aggttctggt ttacattgcc ttttcagccg aagaaagaat tattgcctag
     6481 tgaagagccg aagcctgtta ctttggacaa gatcgcccgt aatgagctta cgatcttgat
     6541 cgctgaggat aattccagta attaccgcct gtttgagtct atattgaaac ctgaatataa
     6601 attaattcat gcatggaatg gaaaggaggc tgtggagcta tttcaccggc acaaaccgca
     6661 attgatcttg atggatataa agatgccggt catggatgga tatgaggcta ccgcagagat
     6721 tcgtaaggtt tcttccaacg tacctataat tgcggtgacg gcttacgctt tcgcccaaga
     6781 tgagcagcgg attattaaaa gtggatttga tgcctatacg gcgaaaccga ttaatgggaa
     6841 ggtcttaaag gacaagatat cgactttatt gacgcatcgg attattctga tgtaatcgaa
     6901 gggctttgcg ggaagcagac ctcataaaac aattaaagcc tgtctcacga caagccctaa
     6961 ccaaactttg ttaaccttaa atctaatact attatgaaaa aaccacgatg caaatatacg
     7021 gagttaccgc tatttgtcaa tagattaagt gctaaattgt gttttgtaac atgtaataaa
     7081 atctaatagg aacttatgcc tcattgaaat ctttcgatag agtcgcatat attctttata
     7141 cctccctctt tttggatcat ctcgcctata tgagcggcat ttttcttata aagcggattg
     7201 gtgaccagat cacaaacctt gcgttcgatc tcctgctcgc tcgctttcgc tatcttaact
     7261 ccttccggcc ctaaccctaa ttggtggatt cgataggacc aatagggttg atcgataatc
     7321 aacggagtga ttaattgggg ctttcccgcc cttcctacgc tatgggtcgt gccgcaacct
     7381 ccatgatgga taacgccgtc gcagtgcggg aatatcaaat tatgcggaac cggctgcttc
     7441 attaagaata aatgtttatc cgcttgtaag gtgattcctg tctttgccca accggaaccg
     7501 atgatgagcc gataatcatg tttcttgcaa atatcgacca aggctttgct gaaacggtta
     7561 ccatccttgg aactacaact cccgagggta aaaaagataa tagggctttg agcgctgtcg
     7621 acgaatgata tcatttcctc gtaagccttc tcatcatatt gaaaagtgtc attgaagcaa
     7681 tagcctccga tcgaccattc gaacgtccag tccggatcta cgtttcctag gtgctggctg
     7741 aaaagcaagt aattatatga acgctctccc gcgtgatagc caaaattgcg aatcggcgcg
     7801 agtccgtatt tagcccggtt cttattgatc gtgtctttga ccatgaaatt ggtcatccgg
     7861 ttcatcaact tccataggat agcgggagtg atgatcgggt tgggtttggg aaatggcaat
     7921 acggccgggg gaatcttctt acccggcaag aacggggcgt aggcggtacg tatcaagggt
     7981 ttcttgcaat actcggcgat acttgcgaca gcaaattccg agttggtcga tactaaaata
     8041 tcatgctctt ttagtagggg aatcaattga tcgaactgtt tatcgatcac gttccgcatc
     8101 catttaagga atggccggaa tttatgtgag ttttgcgctg cgctatcgat cataccgccg
     8161 atatcgtcaa actgttgcaa tacgtattta aatccgtagg gtttaacggt ctcctcgaat
     8221 atttgaggga gattgatggt cacctcatga ccgcgtcttt ccaattcggc cgctatggcc
     8281 aaataaggaa ggacgtcgcc ttgtgagcct ctggttacta atagtatttt catgctacgt
     8341 ttatttatgg gctatgaggg tcttgtttac cggatattca gttgacgcaa acgctcgatg
     8401 tccagatggt atttggcttc catcgtttgt agtttctgct cattgatggc taagggatga
     8461 ttcaatcgtt tcgtttcccg gtatccttta tatacggagc gaatcatctt acgtggattg
     8521 aaaatgacgg atgaggtgat ccagcagccg tgcgtacacc aacagttggc tttataccca
     8581 tgtccgatag cggctatttc ctgtttcatc gcttcgctat tcatcacttt acttatatcg
     8641 caaccatact cttttatatt tccgagcggt tcccgtaact cacaggcacg aaaacgtccg
     8701 tcgtagtcga ttaccaaggt agtctctccg gccgtacaat ccatccccca aggggtcggg
     8761 tgatctatgt tgctggcacg tatattatat aaggtacgta taaggccgag atagaagaag
     8821 cgtgtgatcg gtttccttaa gccggtggta tccgctacca tccgatccgc ataagctgaa
     8881 tagatagggg atatgtcatc ttgtattttg cgtagcgttg actcggttag gattttcacg
     8941 ccatcgtcac gggtcatgcc tctggcggcc tcaatcgtat gtgtggaggt acggaaacgt
     9001 ccgtataccc aagtcatgaa gtcttctacc tggtctatat tgtatttcgt gataacggtt
     9061 gctatatttt tcaagacctt gccgtcgtct ccgaaattct cctgtatctt acgcagggtt
     9121 tccagtgcct tatagaagtt tcccggtacg cctctctgtg tatcgtgggt cgtaccgaaa
     9181 ccatccaagg aaaggcttac gttaatatta caatccgggc agttctggcg gaaccgtttt
     9241 acccattcga cgatccggtc tggttttaag ccgttcgtag ggatgttcac atctttgata
     9301 tggttgtttt tgtagaataa ctccaatatt tccggtagat cctcacgcag ggtaggctca
     9361 cccccggata tccataatcg gttgaattgc ccagcggttt ctgatatttt cttgatttca
     9421 tcgaaagtga ggtcgggttg cttcttatcc atttcttggg catagaagca catcgcgcat
     9481 ttggcgttgc atcggcctgt tacgaaaagg aagatcgact cgagttttct ttccgtgctc
     9541 attgccctga aagaactggt ggttcgtttt ttgtccattt tatttttgtt ttaccatttg
     9601 tcttatctgg cgcatgattt tttccttgtg tttgatcaac acccggagaa aataacataa
     9661 gaagccaaat aaaatactta ttagcatata ctatatgatc tttaaaggca aagatcgacg
     9721 ataaaatgac gctaaacaat ctctatttgc agtattttgt ggtccatgtt taaaaggtag
     9781 gtctataaac aattaaagcc tgtctcacga caagccctaa ccaaactttg ttaaccttaa
     9841 atctaatact attatgaaaa aaccacaatg caaatatacg gacttttcaa ttcctgtcaa
     9901 gatctgtagt gctaaattat gtttttcaac atataacaaa aataaaaagg cgcctttctt
     9961 ttagagaaag acgccttttc catgatatac taatcaaata ttagtcttgt agcttagcgc
    10021 aaatgaactc acggttcaaa cgagcgatgt tactaacgga gatgttcttc ggacactcca
    10081 tctcgcaagc gcgtgtgttc gtacagttac cgaagccaag ttcatccatt ttagcgacca
    10141 ttgctttcgc acggcgggca gcctctacct taccttgagg taataaagcc aactggctaa
    10201 ccttagcgga tacgaacaac atagctgaac cgttcttaca agcggcggca caagcgccac
    10261 aaccgataca agcagcggca tccattgcca tctctgcgtc tggcttagga ataggaattg
    10321 cgtttgcgtc gggtacacca ccggtattta cggatgtgaa accaccagct tgaatgattt
    10381 tatcgtaagc gtaacggtct accatcaagt cgcggattac cgggaaaccg gcggaacgcc
    10441 acggttcgat cgtgatagtc tcaccatcgt tgaaacggcg catatataat tggcaagtcg
    10501 tagctccggt tgccggtccg tgcggatgtc cgtttacata caatgaacac ataccgcaga
    10561 taccttcacg acagtcatgg tcaaaaacaa caggttcttt accttcgctg attaattgct
    10621 cgttcaggat atccaacatt tccaagaaag aagtgccttg gttgatgttt ttaagttggt
    10681 aagtttcgaa ttgtcctttt acattcggac ctttctgacg ccaaactttg agtgtgatat
    10741 ttatatcttt atccatgatt ctaatttttg caatgattga ttacttctta tagttacgtg
    10801 tctgaggaac tacgaattca tagttcaaat cttccttcag cataacaggg tctttatcct
    10861 caccctgata ttcccagcaa gagacataca tgaatttgtc atcgtgacgt aatgcctcgc
    10921 cttcctcagt ctggtgctcc tcacggaagt gaccaccaca agattcagca cggtctaaag
    10981 cgtcatgtgc catcaaggta ccgatctcga taaagtctgc caaacgtaac gctttctcca
    11041 actctacgtt caagtcatct gcgttacccg gaatgaatac gttgctccag aattccttct
    11101 tcaagtcttt caacatctgg atagcctctt tcaagctctc tgcgttacga gccataccga
    11161 tgtgttccca catgatgtgt cccaaacgtt tgtggataga atcaacagac tctttaccct
    11221 tgatgctcat caatttattg atacgggctt ggatattctt ctcagcctcg ttgaactcag
    11281 gcagatcggt gctgaaacgc ggaacctgaa tctggtcaga caaatagttc tggatcgtat
    11341 aaggcaatac gaagtaacca tcggccaaac cttgcatcaa cgcggaagca cccaaacggt
    11401 ttgcgccgtg atcagagaag tttgcctcac cgatagcgaa cagacccggg atagaagtca
    11461 tcaattcata atcaacccac agaccaccca ttgaatagtg caatgccggg tagatcatca
    11521 tcggagtctc gtatggatcg tcgttggtga tttcttcgta catatcgaac aagttaccat
    11581 atttctgttt tacaacctct ttacccagac ggttgatagc gtcggagaag tccaagaata
    11641 cagccaaacc tgtgttatta acaccgaagc cagcgtcgca acgctcttta gcggcacgag
    11701 aagccacgtc gcgaggaacc aagtttccga atgccggata acgacgttcc aaataataat
    11761 cgcgatctgc ctcaggtata tctttacctt tctttgttcc tgcctgtaaa gccttagcgt
    11821 cttccagttt cttcggaacc cagatacggc catcattacg caaagactcg gacatcaaag
    11881 tcaatttaga ctgatagtca ccgtgtaccg gtacgcaagt cgggtgaatc tgaaccatac
    11941 aaggattagc gaagtaagca cctttcttgt agcattgcca tgcggcagaa ccgttagatg
    12001 ccatcgcgtt ggttgacaag aagaacgtat taacgtaacc tcctgtagct acaactacag
    12061 cgtgagcggc gtaacgttcg atcttacctg taatcaagtt gcgggcgatg ataccacgag
    12121 cacgaccgtc taccttaact acatccaaca tctcatgacg agtgtacatc ttaaccttac
    12181 ccaaaccgat ctgacgactc aacgctgaat aagcgcctaa caaaagctgc tgacccgtct
    12241 ggccacgggc gtagaacgta cgcgatacct gagcgccacc gaatgaacgg ttatccaaca
    12301 aaccaccata ttcgcgagcg aaaggaacgc cttgagccac gcactggtcg atgattgagt
    12361 tagaaacctc agccaaacga taaacgttag cctcacgagc acggtagtca ccacctttga
    12421 tcgtatcgta gaacaaacgg taaacagagt caccatcatt ctggtagttc ttagcggcgt
    12481 tgataccacc ttgagcggcg atagagtgcg cacggcgggg agaatcttgg atacagaagt
    12541 tcaatacgtt gaatcccatc tctgccaaag atgcggcagc ggaagctcca gccaaacctg
    12601 taccgactac gataacatcc aaacgacgct tgttagcggg gttcaccaat ttctggtgat
    12661 ttttataatt agtccacttc tcagccaacg ggccttgagg tattttagaa tttatttcag
    12721 acataatgat ttaatttcaa aagttcttaa ttataaaacc tgtagcttgc aattaagcac
    12781 ctactccgtt taggaagaag atgatagtaa tgattgcgaa aagtccgcaa ataaccgtag
    12841 ctacgatctt agagatacat tcccaacggt tcatccagat cgtgttattc caaccgattg
    12901 tttggatagc gctccagaaa ccgtgagtca agtggaacca caaagccacg taccagatca
    12961 aataaagaac ggtgatcacg gcattacctt ggaagtaata gttgataaaa gcggctccgt
    13021 cttgtggaga taccatagct gaccccaatg ctacttcgtg atgaccgatc aattcggcga
    13081 acatcatctt ataccagaac tggctgaagt gcaacagcat gaacaggata acgatcaaac
    13141 ccaaaacgaa catgttctga gatgcccatt ctacgccttt cggacgagcg ttgatagcgt
    13201 aacggtcgtt accacgtgcc ttacggtttt gcaaggtaag aatgatagcg tacacgaagt
    13261 ggatcacaac gcctgcggcc aatacgagag tagctgccac agcgtaccaa ttagagccca
    13321 acagcgaaca aaccatgtta taagcctctc cggagaaaac ggcagccacg ttcatcgaca
    13381 ggtggaacaa taagaacaaa acaaggaaga gacctgatat gctcattatc agcttcttcc
    13441 cgatagaaga attaagtaac cacataagat aataatttaa gttatttaat tgtatttaga
    13501 aatttctact taaactatgt aattatcacg caaaggtatg ctaaatccat atatcgcgca
    13561 aacgattaaa gaaatatttc tgcattaatg ggagaggtca gggcatgtgc cccgacacat
    13621 gaaataatgc ggaaggaaaa ggctttcctt atgaataatt tatatacatt tgcctatatg
    13681 cgtaaggatt tgaatgggcc acggcatttt tctatagggg tcaagtttac gatcttattg
    13741 tttacgatcg cgatcttggt tcttgtgctt ttctcgtata ggagcgacaa gcatggcaac
    13801 ctgttctggc aggtagagaa attgattccg catcatccgg acagcgcttt ggtgttatta
    13861 gagaaagtga cagatatcaa tggattatcg cttcgagaga aagcccgtta ttgtctgtta
    13921 tggaccgaat cacgggatga ggcgggattg aggcatacat cggattccat aatctctatc
    13981 gctacggatt attataggac gacacgaggc tgttactggc ctcccaaagc gtggttttac
    14041 cgggggaaag tctatgagga tatggatcaa ccgtccctag ctttggaatg ctatttacgt
    14101 gcgttggaat atgagggagg gaattgggat tacgaatttt ggggacggtt atataaccag
    14161 atagggaggc tgtacgccga gcaggaatta tatagcaagg ccatgtcttt tttgagaaaa
    14221 gcgagtgccc aatatcagct cttgaatgat acggccggac aaggccggat actggaggaa
    14281 gtcaagaaat acgaggcgtt acgggattct atcggatcgc tgtcagcgag agaatcgatt
    14341 tatcagatca cttcccggta tgatgtaagg ccggttcgtg aggacttgta taggaaagaa
    14401 ttgatgctat cgcaaagggg acaggagcgt tatctgtacg catttattat cggcataatc
    14461 ctatttattt gcttcctcct ttatcggcga tggagagata cgcaggaaaa cgctcttcga
    14521 agggaagaag ccttgcggcg ctcgattgct agccagcaac aacgtatgcg agaagaaaaa
    14581 gaagagaatg aacggcaaat cgcccttttg gaaaagagaa ttacgaaaat aaaggaagaa
    14641 aaggatcaag agttgatgtt ggtttcctta caattggaaa aacaaaggct ggagatttgt
    14701 aacgagtcga ttcataataa ggagagtaag catttattat ctgtcgcgat cttgcggaaa
    14761 tcggaggtct atgagaagtt tcacgatcgg gatgccgaca agattgtctc tgaggattgg
    14821 gagcttttgg aggtgctgtt gaataaggct tatgatgact ttaccttacg gctgaaaaaa
    14881 ctatatcctg ctatttccga tacggagttg aaggtctgta tgcttacgaa gatcggcgtt
    14941 cccgccaacc agatcacacg ggtattgaaa tataatagtt cggtacttcg tcctcgtctg
    15001 ttccggaaga tttttaagaa agaaggttct acggaggcat ttgtggagtt tatctcaagt
    15061 ttttgattat tatgtattta tagctgtctt ggcaggtttg ttctcatttt tgttctcatt
    15121 tatcatgtga tttgtgagat atgcgggata tttttggagg caaaaaagca tggttatgaa
    15181 aagtgtaaag ttagcctcta tcttgtttta tttaaatagt gtttttgtcg tttcttgttt
    15241 cgtgtcatgc ggttcttcgc caacggaagc gccctctctt ttaaccgcag atataagagg
    15301 ggggatggat aaaccgaggc tattgggatt aggcgatgag atcaaggggg ttacttttgt
    15361 ccctttagag gtgaccacgg atgatgcctc gttgatagac ggagtttatg attatgccgt
    15421 gacagatcga tatatctatg tgcttcccgt aaaagagccc cgtatcgtcc tgttcgatcg
    15481 gcaagggcgt tttatccgga cgttggtaaa agaagggcag gggccgggtg aatttagcgg
    15541 tattctgcca tgtatccaag tggacgaacg taatgaccgc ctttttttat ttagtaataa
    15601 tcgagtttgg gaatatacgt tggaaggtga atttatcgga caatccaccc atgagtattc
    15661 ggtaatctat atgcgtcata tcggaaagga tcgtttcgcc gccatatcat tcccttttca
    15721 gcctttcaac ggagggggat tcggattagg cctattttcg aggaaagggg atacgatagc
    15781 gatcaagaat gatttttatt cctttttatt acctcatgag aagagcgggt tcacgacaag
    15841 tatcgccccc gcttattctg atgcgcaaaa ctccgtgttg tttaagaccg gtagcaatga
    15901 tacggtcttc agtatctcgg cggatcgaat aagtgcggct tgtgtccttg atctgaaaaa
    15961 ctcggatgcg gaagtgattc gttcgttgga tgttacggac atgagtattt gcgaattgaa
    16021 aaaaaaggcc cccaaggata tctttgtgca agatatgatt gagtttccgg aacattatta
    16081 tttccgttta ttgtataacc aaggctatta tatagcctct gtagataaaa agacgggaaa
    16141 gac
//
