LOCUS       c00084_gnlPro..        11067 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DLEEINDK_84.
ACCESSION   c00084_gnlPro..
VERSION     c00084_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 10:48:53
            Original ID  :: gnl|Prokka|DLEEINDK_84
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11067
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11067
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1143:7100]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1144..7100
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11067
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11067
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             149..988
                     /locus_tag="ctg84_1"
                     /transl_table=11
                     /translation="MHKGLLVVGRGIGQVMFQGNALSGLLMLIGIACSSWTLALLALAG
                     NIASTLAAYLLGYSREDIREGLYGFNGTLVGIAIGVFMRINIGSISLLLMGSALSSGIA
                     RQFNRQNKLPGYTAPFILSVWILLILCRYLFPSLMLPTVATPPGHVPDLLHAFTANIGQ
                     VMFQGNMLTGLFFLLAILVNSRLNAAYTIWGASLPLGMILLPATSIADFNMGLLGYNGV
                     LCAIAAGNHLSIRSLIRATLAILLSIGLQIGGMRLGITTLTAPFVLSVWITNLIIKE"
     CDS             complement(1144..2187)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_2"
                     /sec_met_domain="IlvN (E-value: 1.6e-47, bitscore: 150.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.1e-40, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYEKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPTDIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(2237..2962)
                     /locus_tag="ctg84_3"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDVEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             complement(2969..3523)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_4"
                     /sec_met_domain="ALS_ss_C (E-value: 1.2e-17, bitscore:
                     53.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             complement(3539..4462)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.8e-51, bitscore:
                     163.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MHGNVGPNRKTNECDVLIAIGMRFDDRVTGDLKTYAKQAKIIHLD
                     IDNSEIGKNVAVDVKVLGNAKHTIPMITALLEERKRPEWNAEFDRDEKEEYDKVIEKEL
                     YPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQMMGVRYFKYKQTRSVVTSGGLGTMG
                     FGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELGTIMQEKLNVKIIILNNNFLGMVRQ
                     WQELFFHERYSNTIMENPDFVAIAKAYGIAGRAVEKREELDDAIAEMLNHDGAYVLVAN
                     VETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             complement(4425..5231)
                     /locus_tag="ctg84_6"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVEYEYKKVDYVRSYQPEPDINKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELKAFLQKNDIPAGSTVLGLSALPIEQGNARHAWKRRAEPENE"
     CDS             complement(5265..7100)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg84_7"
                     /sec_met_domain="ILVD_EDD (E-value: 2.7e-217, bitscore:
                     711.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFT
                     QFVPGHTHLHEIGQLVKAEIEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMASMRLNLPTVFVSGGPMEAGELDGRHLDLID
                     AMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     KNRIQLFRDAAKQIVENAYKYYRDGDDSVLPRNIATRQAFLNAMTLDIAMGGSTNTVLH
                     LLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAG
                     LVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELD
                     TDRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSDEELAERRKAEEARGKK
                     AFTPPMRQREVSKALRAYGKMVSSADKGGVRIVED"
     CDS             8197..9423
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg84_8"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.2e-41, bitscore:
                     132.4, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTPIAIKKLIVNKNMKHYNFDEVIERHGTSCVKFDRLKEMFGDEN
                     LIPLWVADMDFRTPDFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHYKHNWKIQREW
                     IXXXXYMPGIVKGIAFAIQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDG
                     VYEMDFDHLESIIDDKCKVLILCNPHNPGGIVWKKETLVRLAEICAKHNILVISDEIHA
                     EMAYPQYTHYPFASVSDTAASCSLTFMAPSKTFNIAGIVTSYAIVPNDRIREEFYSFLE
                     AGEFGDGTIFAYTATTAAYTYGAEWLQQMRMYIMENVRFVEEFMKLHLPKIKVYQPQAS
                     FLVWLDCRELELSQDELVHLFKDKAGLALNDGSIFGPGGEGHMRLNIGCPRSVLDKAMN
                     ALKKAVDKK"
     CDS             9472..10062
                     /locus_tag="ctg84_9"
                     /transl_table=11
                     /translation="MKXXXXXXXXXXYVAVTYDLNVGEGEERELMEKATVEAPLKFIYG
                     TGMMLPAFEKALNGLEVGGTFNFSIEPAEAYGEYNEEHVLDLPKNIFEVDGKFDAEMIK
                     EGNTVPMMDSNGNRMNGSVLEVKDDIVVMDFNHPLAGETLHFSGEVIDVHEPTAEEIAA
                     FSAPAGGCSCGCDDCGSDCGDNHEGGCGCGGCH"
     CDS             10166..11065
                     /locus_tag="ctg84_10"
                     /transl_table=11
                     /translation="VNTFGNIYRLTSFGESHGPGIGGVIDGCPAGIELDTAFIQQELNR
                     RKPGQSRITTPRKEDDEVQFLSGIYEGKTTGTPIGFIIWNKNQHSSDYDNMKTIYRPSH
                     ADYTYQTKYGIRDPRGGGRSSARETIARCVAGAIAKLALKQYGIQIQAYTSQVGPIQLA
                     GSYQDYDLSLTEESDVRCPDPKTASEMETLIAEVKSKGDTIGGVITCVAKGVPVGLGEP
                     VFGKLHATLGHAMLTINAVKGFEYGDGFNAAFFRGSERNDRFFNDNGHINTRTNNSGGI
                     QGGISNGQDIYFRVAFKSV"
ORIGIN
        1 ataagcggtt atttgcaaaa aaacgcaaaa gaaacaggtt gacgatcatg ccgcaaaaca
       61 tatcgtaacc ggaatcttgg cacagttgcc cgaattacgc tcgtgattgt gctattttcg
      121 ttattttcgc agtcaaaact aaaatggtat gcataaggga ttactcgttg taggccgggg
      181 aatcggtcaa gtgatgtttc aaggcaatgc tctttccgga ctattaatgc tgataggtat
      241 tgcctgtagt tcatggactt tagcgttatt ggcgttagcc ggcaatatcg caagcacgct
      301 ggcggcctat ctcctcggat attctcgcga agatatacgc gaaggactat atggtttcaa
      361 cggaacactg gtaggtatag cgatcggagt attcatgaga ataaatatcg ggtcgatatc
      421 tctgcttctt atgggatccg ccttatcaag cgggatcgcc cggcaattca atcgccagaa
      481 taaactaccg ggatatacag ccccattcat actttcggta tggattttat taatcctatg
      541 tcgatatcta ttcccttcgt tgatgcttcc aaccgtagcg actcctcccg ggcatgtccc
      601 cgatttactt catgctttca ccgctaacat cggacaagtg atgtttcaag gcaatatgct
      661 aacagggcta ttctttcttc ttgccatctt agtaaactca cgcttaaacg cagcctacac
      721 aatatggggc gcgtcgctgc cattggggat gatattacta ccggcgacaa gcatcgctga
      781 ttttaacatg gggttgctcg gctacaacgg tgtattatgc gctatcgcgg caggcaacca
      841 tctttctatc cgtagcctga tacgggcaac cttggcgatc ttactatcta tcggattaca
      901 gattggcggc atgcgtctgg ggatcacgac ccttaccgcc ccattcgtac tctccgtatg
      961 gataacaaac cttataataa aggaatgatt ccagcatcat ccatttaata atgattacga
     1021 ctatgacgaa attaagcaac atccccgtaa aagaaacagc ggccaaggcc gcaaggacac
     1081 gcaaggcgag ccacccgtaa gtgacccgcc tctttttgct gatatataag gattaagatt
     1141 ggattagttg ttctccggac gaagcttgcg tacggtaaca gcagtctgcc acatctcgct
     1201 ctcgcgcaac gccttcaatt cagcctccaa tttctcacga taatccggct tagagttaga
     1261 atcgatagag atctgagcct cgttaccgca ttttacgttc gcatacaatt tctcgacaac
     1321 cggcttgatt gcgtcgtgga acggacccat ccagtccaaa gcgccacgct gggcagtcgt
     1381 agagcagtta gcgtacatcc agtccatacc attcttggcg aataagggca tcaaggattg
     1441 agtcaactcc tcgaccgtct cgttgaaagc ctcggaagga gtatgtccat tctcgcgcaa
     1501 tacctcatac tgggccaaca acaaaccttg gatagcgccc atcaaagaac cgcgctcacc
     1561 ggtcaagtcg gaagtagcct cacggatgaa agtcgtctcg aacaaataac cggaaccgat
     1621 accgataccc aacgccaacg tacgatccat tgccttgcca gtagcgtctt gatagatagc
     1681 gaaagaagag ttcaagccac gaccctcaag gaacatggaa cgcaaagacg taccagaccc
     1741 cttcggagcg accatgatca cgtcaatatc cgtgggagga acaacgcccg tacgatcgtt
     1801 ccaagtgatc gcgaaaccat gagagaaata cagggccttg ccagctgtca gataaggctt
     1861 catcgtaggc catacagaca ttacggcagc gtcggacaat aagcacatga tgatcgtggc
     1921 cttgtcgcaa gcctcctcga taccgaacag agtctcaccc ggaacccatc cgtcctcaac
     1981 cgctttctcg taagtcttac cttggcgctg gccaacgatt acgttgaagc cattgtcacg
     2041 aaggttcaat gactgtcccg gtccctgtac gccatagccg ataacagcga ttgtctcatc
     2101 ttttaatatc tctcttgcct tttccaacgg aaattcctcg cgggtcatta cattctctac
     2161 aacaccgcca aaattcattt gtgccatttt ctttttaact attaatgttt aaaaacctat
     2221 ttatgtatct cttttattat ctccaagtaa ccgccgcacg acagatcgcc tttccctcat
     2281 ggcaaatagc catgtcttgc ttatcgggag cggactccgc cttatgaagc gtaagcggca
     2341 taccttgttt accctcggat tggtaggcga tctccagacg gccgatctca cgggtcttga
     2401 actggtcgat atcgaacaaa tccagcagat gctcgatata cttcacgcta ttgaagtgac
     2461 cgttgatatc caagtcgctg tatttgatcg aatacgggat tccctccgcc ttattctccg
     2521 ccggcatgat cttgcccggc ttctcgatcg ggcacggacg ctcgtcgata tatttgccca
     2581 atgcctctac atccaataag gtaggacggc gggtctccac gtcgatagcc gcccaaatag
     2641 aacgggcaaa tccaaaggtt ttcccattct catccgccag ctcaaaacaa cggctggtga
     2701 agaggcgtcc gacctcatcg atccaagtgt atagattaat cttatcgaag gcggtaggat
     2761 attccttcat ctcgatagcc agacgggaca acacccaagc cgtatgacgc tccgacatat
     2821 cattgaaacc gaacccacgc tctccggcat ggctggaagc ggcgtgaatc aaatagttac
     2881 caatcatagg gagcgttaca cgtcccctaa aatccatcaa atacggctcc gccacgaaat
     2941 gaaataatcc tactttctcc atatcttatt attgttgctt ttcatgtaac tttcgctcca
     3001 tatcggccaa catatcgctc aagcgctcca ccttgctctt cgtgatagcc acacgtccgg
     3061 agcggatgaa ttgcaggaca ccgatcgtct cgctcaactc attgaacaag gcttgtgtct
     3121 cgtcataatg gccactcttc tccaatacca cgcaggtctc gttcatctcc aagatacgag
     3181 cgttgtattt acggatcaat ccctccacgg ttcccatctt gatgaaaagc tcggtactta
     3241 gcttataaag agcgatctct tgataaacca aatcctcatc cgtattataa taagccttca
     3301 agatatccac acgtttatcg atctgtttca ccaccttatc gatcatatcc tcatcggcga
     3361 atgtcgtgat cgtaaactta tggatgccct tgatagcgga cggagagacg gacagagtct
     3421 cgatgttcag ctgtcggcgt gtaaagataa tcgttatctg gttcaaaaga cctacgatat
     3481 tctctgaaaa gataataacg gtatataatt tctttgttgt catagcttca tctcctcctt
     3541 atttctcgtc tcccataatc atgtttgtca cgcttccccc ggcaggaacc atcggatata
     3601 ccattccgca agtctccacg ttagcgacca acacgtaagc gccgtcgtgg tttagcatct
     3661 cagcgatagc gtcgtccagc tcctcccgct tttcaacggc acggccggcg ataccatagg
     3721 ctttagcgat cgccacgaaa tccggattct ccatgatggt gtttgaataa cgctcgtgga
     3781 agaacaattc ttgccactga cgtaccatac ctaagaagtt attattaaga atgataatct
     3841 tcacgttcag tttttcctgc atgatggtac ccaattcttg aatcgtcatc tgcatacccc
     3901 catcaccggt aaagaagcag accgtacggt ccggagctcc gaacttagcg cccatagcgg
     3961 ccggcagacc aaatcccatc gtacctaaac caccggaagt caccacgcta cgggtttgtt
     4021 tatatttgaa atagcggacg cccatcatct ggttctgccc aacgtcggtc accaatacag
     4081 cgtcgttacc ggtcgcctcg gaaaccttac ggactacctc gcccattttc agttggccct
     4141 cggtcggata caattccttc tcgattacct tatcgtattc ctctttctcg tcccgatcga
     4201 actcggcatt ccattccgga cgtttacgtt cttctaacaa cgccgtgatc attggtatcg
     4261 tgtgcttggc attccccagc acctttacgt ccacggcaac attcttgccg atttccgagt
     4321 tgtcgatatc cagatggata atcttggctt gcttagcgta tgtctttaaa tcgccagtca
     4381 cacggtcgtc gaaacgcata ccgatagcga tcaatacatc acactcattc gttttccggt
     4441 tcggccctac gtttccatgc atgccgagca ttcccttgtt caattggcaa cgcagataag
     4501 cccaataccg tagatccggc aggtatatca ttcttttgga gaaacgcttt caattcctct
     4561 tccgcaccgc ctaacaatac tccctgtccg accagacaga agggtttctt cgcctcattg
     4621 attaaatcgg cggcggcctt gatacgatcc ttattgatat ccggctccgg ttgataacta
     4681 cgtacgtaat cgaccttctt atattcatat tccaccaacc ctacttgcgc gtccttcgct
     4741 aaatccagca caactggacc cggacggcct gtagaagcga tataaaaagc acgagaaaca
     4801 gcccatgcga tctcctccgg cttgcggatt tgataagccc atttcgtgat cggttgcgtg
     4861 atgccaatca cgtcgacttc ctgaaaagca tcggttccca acaacggcga gggtacttga
     4921 ccggcgatta cgaccattgg cgtactatcc atcagcgcat cagcgatacc cgtgatggta
     4981 ttcgtagcgc ccgggccgga agtaaccaac gtcactccta ccttgccgga tacacgggca
     5041 tatccttgag ccgcatgggt agcgccttgc tcgtggcgca ccaatacatg cctcaactgg
     5101 tccctataat catataaact gtcgtaaata ggtatcgcct gtcctccggg ataaccgaag
     5161 atagtatcta ctccttcagc aatcaacgct ttcagcaaag cttccgaacc ggttatcttt
     5221 tgtttctcca taagaaataa cgtgtttaat gtatattatt ggctttaatc ttcaacaatc
     5281 cttacacctc ccttatcggc ggagctaacc atcttcccgt acgctctcaa cgctttcgag
     5341 acctcacgct gacgcatcgg cggcgtaaag gctttctttc cacgtgcctc ttccgcctta
     5401 cggcgctcgg ccaactcctc gtcgctcaac cgcacgttga tggaacgttc cgggatattg
     5461 atctcgatga tatccccgtc tctcaccagt ccgatagcgc caccggaagc ggcctcggga
     5521 gagatatgcc cgatagaaag accggacgta ccgccactga aacgaccatc cgtgatcaag
     5581 gcgcactcct tacctaagtg acggctcttt atataagagg taggatataa catctcttgc
     5641 attcccggcc cccctttcgg cccctcatac gtgatgacga ccacatcgcc tgaaacgacc
     5701 ttgcctccta aaatgccctc gcaagcggca tcctgtgaat cgaagacttt cgccgggccg
     5761 gagaatttcc aaatactctc atccacaccg gcggttttta cgacacatcc gtccaaggcg
     5821 atattccctc tcaaaacagc caagccgcca tccttggaat aagcgtgctc cacgtcacgg
     5881 atacaacctt cggcacgatc cgtatctaat tccttataat aagattcttg ggagcccatc
     5941 tggatactga accgatgagc gggagcgctc ttgtatttac gaatcgcctc ctccgttacg
     6001 ttcggggaag tgacggcgta tttatcaaca gcctcggcca aggtcaggcc gtccgcacgt
     6061 ctcgtgctgc catccacaag cccggctttc atcaactcgt tcatgatacc gaggattcca
     6121 ccggcacggt ttacgtcttg tacatgataa gtgtgcgtat tcggggctac cttacacagg
     6181 caaggagtct tgcgggataa catatcgata tcctccatat gaaaatcggc gccggcttct
     6241 tgtgccacgg ccaataagtg aagcactgta ttggtagacc cccccatggc gatatccagc
     6301 gtcatggcat tcaagaaagc ctgacgggta gcgatgttgc gaggtaacac ggaatcatcc
     6361 ccgtcacgat agtatttgta agcgttctca acgatttgct tagccgcgtc acggaaaagt
     6421 tggatacggt tcttatgggt agccacgatc gtcccgttac ccggaagcgc cagaccgatc
     6481 gcctcgttca agcagttcat agagttagcg gtaaacatac cggaacaaca accgcaaccc
     6541 ggacacgcat ggcgttccac ctgctcgata cgctcatcgc ttaccgatgt atcggcagac
     6601 tcaatcatcg catcgatcaa atcaagatgg cggccatcca gctcacctgc ctccatcggg
     6661 ccaccggaca cgaacaccgt cgggagattt aatcgcatgg aagccataag catacccggc
     6721 gtgatcttat cgcaattgct gatgcaaacc atagcgtccg ccttatgggc atttaccata
     6781 tattccacgc tgtccgcgat aatgtcgcgt gaaggaagcg agtaaagcat cccatcgtgc
     6841 cccatagcga taccgtcgtc gatagcgatc gtattaaatt cagcggcgaa acaaccttgt
     6901 ttctcgatct cggccttgac caattgcccg atctcatgca aatgcgtatg ccccggcacg
     6961 aactgggtaa atgaatttac gatagcgata ataggcttgc cgaactgttc ctctttcatc
     7021 ccgttggcac gccatagcgc acgggctccg gccatcctac gaccttcggt gctaaatgag
     7081 cttcttaacg gattcttcat ctctttccta ttttttgttc gtagagcgct ttatccacgc
     7141 ctctaccttg atttatttat aataaaaaag cctttcccta tatggagaaa ggcttaagaa
     7201 atatctctac gacttcacaa cttcttacac acctttctcc ttacctacta atgactagaa
     7261 ggaccaccac gagaataata tgcaatacgt tgttcatcat cttttcttat tgtctttgtt
     7321 tgtttgacgc tgcaaatgta gaacaataat tgannnnnnn nnnnnnnnnn nnnnnnnnnn
     7381 nnnnnnnnnn nnnnnnnntc atttttcttt caattctcaa gcaaatacca ttttaggatt
     7441 gcattttaac aggagcaaga gtgtattact taggaatcgg aaggtataga agggaaaaaa
     7501 cttcgatttc caaacagaaa cagtaaaaag acaaatgtta tctaaaacag attccagata
     7561 acatttttat cagataacac gacttacgat aacacgtatc tcataagaaa atcctattct
     7621 agcgataaaa aagatacata taaactctaa atcacatatt tattaacact tgtagactat
     7681 aaatagcctt gaaaaaattc ataatagtgt tctagaaaaa acataaggaa gttttctgaa
     7741 gaacataagg aataaatttc atctagtatc ggactaaatt ttgttaacat ccgaatgaaa
     7801 atcacctaaa atcaagacta aatccggcat aacccacgct agaagcagct caagcgaaga
     7861 cattttcaaa atgactttca gacagagaaa gccttaaata ctcaaccgat agacagctct
     7921 tcaaacatca atcataaaaa aagaccaaca agacctgcat tcaaacatca ttctgattta
     7981 cacaaccatc aaatgcttgc gctttttccg tgcgaccaag cccccgcccc ataattcatc
     8041 acccacagag agcaataata gcactttgac attttgccag ttcacggttt gataagccgt
     8101 ttaagtaaac gattcattaa atatatcgcc gatttcctaa tatacagtat ttcatatttt
     8161 gatttggata aacaataaat ataataattt gtatctttga ccccaatagc aattaagaaa
     8221 ctgatcgtta ataaaaatat gaaacactac aacttcgacg aagttatcga acggcatggg
     8281 acgagttgcg tgaaattcga ccgtttgaaa gagatgttcg gtgacgagaa tctgatacca
     8341 ctatgggtgg cggatatgga tttccgcaca ccggacttta ttgtagaggc cctgaagaaa
     8401 cgttgtgagc acgagatatt cggctataca ttcggctccg acgagtatta cgagagtatc
     8461 atcaattggg tacactacaa acataactgg aaaatacaac gggaatggat cannnnnnnn
     8521 nnctatatgc cgggaatcgt gaagggaatc gctttcgcta tccaatgctt tacgcaaaaa
     8581 ggagataagg tcatcatcca gccccctgtt tatcatccgt tccgcatcgt tccggaaaaa
     8641 atgaagcgtg aggtcgttta taatccgcta aagatggtag atggtgttta tgagatggat
     8701 ttcgatcatc ttgaatctat tatagatgat aaatgcaagg tattgatcct ctgcaaccct
     8761 cacaatccgg gcgggatcgt ctggaaaaag gaaaccttgg tccgattggc cgagatttgc
     8821 gccaagcaca atattttggt tatctccgat gagattcatg cggaaatggc ctatcctcag
     8881 tatacgcatt atccattcgc ctccgtatcg gatactgccg cttcttgcag cctaactttc
     8941 atggcaccga gcaagacgtt caatatcgcc ggtatcgtga cttcctacgc aatcgttccc
     9001 aatgatcgca tccgggaaga attttattct ttccttgagg ccggagagtt tggcgatggc
     9061 acgatcttcg cttatacggc gacaaccgcc gcttacacct atggtgccga atggttgcaa
     9121 caaatgcgaa tgtatatcat ggagaatgta cgtttcgtgg aagagttcat gaaactacat
     9181 ctccccaaga taaaagttta ccagccccaa gcctccttcc tcgtttggtt ggattgcagg
     9241 gaactggaat taagtcaaga tgaactcgta cacctgttca aagacaaagc cggactagcg
     9301 ctgaacgacg gaagtatctt cggccccggg ggagaaggcc atatgcgttt gaacattggt
     9361 tgcccccgct ctgttttaga taaagcgatg aacgctctta aaaaggcggt ggataagaaa
     9421 taaaatcgta tctttgcgag catttctata catatttaaa atacaagaca aatgaaaann
     9481 nnnnnnnnnn nnnnnnnnnn nnnnnnntac gttgcggtta catacgacct gaacgttggc
     9541 gaaggtgaag aacgtgagtt aatggaaaaa gcgacggtcg aggctccttt gaaattcatc
     9601 tacggaacag gcatgatgct tccggcattc gagaaagcct tgaacgggct ggaagtaggt
     9661 ggcacgttca acttctccat cgagccagcc gaggcttatg gcgaatataa cgaggagcac
     9721 gtattggatc ttccgaagaa tatcttcgag gtggacggta aattcgacgc cgagatgatc
     9781 aaggaaggta ataccgtccc aatgatggat tctaatggca accgtatgaa cggctctgta
     9841 ttggaagtga aggatgatat cgtggtaatg gacttcaacc atccgttggc tggcgagact
     9901 ttgcacttca gcggcgaggt aatcgacgta cacgaaccga ctgcggaaga gatcgcagcc
     9961 ttctccgctc ccgcaggtgg atgcagttgc ggttgcgacg attgcggtag cgattgtggc
    10021 gataaccacg agggtggttg tggttgtggt ggatgccact aaataatggg aaattgagaa
    10081 ttgaaaattg aaaattagga gaaacgccta atcatcggct tttgattctc aattttcagt
    10141 tttcaatttt caattagaca aaacggtgaa tacttttggt aatatttata gattaacatc
    10201 gttcggcgaa tcgcacggcc ccggtatcgg cggcgtgatc gacggatgcc cagccgggat
    10261 cgaattagat acggcattca tccagcaaga gctgaaccgt cgtaaaccgg gacaatcccg
    10321 tatcacgacc ccccgtaaag aggatgatga ggtacagttt ctttccggta tctacgaggg
    10381 aaagacaacc ggcacgccga taggtttcat catctggaac aaaaaccaac attcctcgga
    10441 ctatgacaat atgaaaacga tttaccgtcc ttcccatgcc gattatacct atcaaacgaa
    10501 atatggaatc cgtgaccccc gtggaggtgg acgttcgtcc gcccgggaaa cgatcgctcg
    10561 ttgcgtggct ggggctatcg ctaaactcgc ccttaaacaa tacggcatac agattcaagc
    10621 ttatacctcg caggtcggcc cgatccaatt agcgggtagt taccaagatt atgatttaag
    10681 cttgacggag gagagcgacg tacgttgccc ggacccgaag accgcctcag agatggaaac
    10741 cttgatcgcc gaggtcaaat caaaaggaga tacgatcggc ggtgttatta cctgtgtggc
    10801 gaaaggggtt cccgtcggat tgggagagcc tgtgttcggc aagttacatg ccacattggg
    10861 acatgcgatg cttacgatca acgccgtgaa gggcttcgag tatggagacg gattcaacgc
    10921 cgccttcttc cgcggatcgg aaaggaacga tcgctttttc aatgataacg ggcatatcaa
    10981 tactcgtacc aataattccg gcggtatcca aggagggatc tccaacggac aagatattta
    11041 tttccgggta gcctttaaat cggtcgc
//
