LOCUS       c00021_gnlPro..        24536 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OECOAAEK_21.
ACCESSION   c00021_gnlPro..
VERSION     c00021_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 10:53:14
            Original ID  :: gnl|Prokka|OECOAAEK_21
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 21064
            Orig. end    :: 45600
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..24536
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[31064:35600]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14536
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..24536
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..24536
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             581..1102
                     /locus_tag="ctg21_25"
                     /transl_table=11
                     /translation="MSFLELARKRCSIRKYAPKNVEQEKIDYILEAARLAPSAVNYQPW
                     YFVWVQSAEGKAKLQECYPREWFKQAPYYLIVCGDHQQSWKRGDHKDHMDIDTAIATEH
                     ICLAAAEQGLGTCWVCNFDTELCRKHFKIPETIEPVVLIPFGYPSDPALFDETPKKRKP
                     IEEIIKRESF"
     CDS             1104..1670
                     /locus_tag="ctg21_26"
                     /transl_table=11
                     /translation="MLYIEVLLLAIGLSMDSLAVSVTGGAVLKNNCTAGNIIKIASVLG
                     IFQAGMTVIGYTMGLGFEKYICAFDHWIAFTLLLYLGGKMIYDSTKEEEEDGKFDPLCN
                     RTLCGLGIATSIDALAVGISLAILKSPLLLQASTIGVVTFAISAFGVYFGNRFGKRIDL
                     KLDLIGGLILIGIGTKILIEHVFFS"
     CDS             1715..3439
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ILVD_EDD"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_27"
                     /sec_met_domain="ILVD_EDD (E-value: 2.2e-183, bitscore:
                     602.4, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSQQLRKLAPELDSLRLGSGWKIDELSKPQIIVESSYGHSHPGS
                     AHLDKLMDEAGIGIKEKGGRAANYFVTDICDGEAQGHDGMNYSLVSRDIMAAMMEIHVK
                     ATPFDAGVFIASCDKSVPAHLMAIARLDMPAIFMPGGIMKAGPNLLTLEQIGTYSAQYE
                     RKEITEEQFMVYKRDACPDCGACSFMGTASTMQVMAEALGIALPGSALIPAHLPELKET
                     ARKAGEHALGLAKEELKPSDIMTIQAFENAIMVHAAIAGSSNSLLHLPAIAHELGIQLS
                     PDLFDKIHRKIPYLLNIRPSGFWPGEYFWYAGGVPAIMEEIKEFLHLDVMTVTGKTLEE
                     NLKDLQLNGFYENCHKYLPALGVKVGDIIKPFHTPIKAQGAIAILKGNLAPEGAVVKHS
                     AISPRLMQVTLKARVFDCEENAIEAVLQKKIHPGEAVFIRYEGPKGSGMPEMFYTTEAI
                     ASDPELVETIALITDGRFSGATRGPAIGHVSPEASEGGPIALVENDDLIRIDIPARTLD
                     IIGTDSIERSVEEIEKILSERRAHWIKPESQYKKGILDIYTHNSVSPMKGAYMEFFM"
     CDS             3465..4493
                     /locus_tag="ctg21_28"
                     /transl_table=11
                     /translation="MRKNITILVSLLILSHTACSDKGQYFEESGSVFHTSYHIKYKAKQ
                     ILTDKIDSELQRFNLSLNPFNPNSTIAKVNNNEDVEVDEWFTEVFNKAEEISQKSGGAF
                     DITCAPLINLWGFGFSKMDSVTPQMIDSIKAFVGYQKVRLEGKKIIKEDPRILLNCSSI
                     AKGYACDVIARLLEKEGVKNYMVEIGGEVTMKGVNQQGDCWRVGINKPEIGTSGVTNDV
                     EEIVQLCQKGGVATSGDYRNFYIKDGKKYAHTINPATGYPAGQNILSATIVAEDCMTAD
                     AYATTFMVLGVEKAKLLAQSIPQIEYFIIYADNNGQQKVTYSKGMLEYLPNRKTLAILE
                     NP"
     CDS             4502..4879
                     /locus_tag="ctg21_29"
                     /transl_table=11
                     /translation="MKRYLNQLECKILRAGDSLFNTTTTDNLLIFVFSGKLIIYSQEGT
                     HIAEVAKDHFMLLAQNTNHKVIASTPTRLILIHAGSLSDMIINDPEWNVEKPVVLPIPP
                     ALAHTLNQIEYYMKDKYFTLN"
     CDS             complement(4882..5463)
                     /locus_tag="ctg21_30"
                     /transl_table=11
                     /translation="MLENLKKYKIVLASNSPRRRNLLSGLDIDFEVRIIPDIDESYPDS
                     IDSMEIPLYIARSKAEAYKSTMADDELLITADTIVWTFDGVMGKPANREEAYAMLHALS
                     DHVHQVITGVCIMTKDKNVGFSVESAVCFAKLGDEEINYYLDKYKPYDKAGGYGIQEWI
                     GYIGVEAINGSFYNVMGLPVQKLYQELKHF"
     CDS             complement(5501..6022)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HAD_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_31"
                     /sec_met_domain="HAD_2 (E-value: 2e-08, bitscore: 26.4,
                     seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSINYDLRKIKAFVFDVDGVLSCDVIPLHPNGDPMRTVNIKDGY
                     ALQLAVKKGYEVAIITGGYTEAVQIRFSRLGIQHIYMRSAVKVHDFKDFMEKTGLSPEQ
                     IMYAGDDIPDYEVMTRVGLPVAPADAAPEIKEIAKYISSRRGGEGVARDVIEQTMRAQG
                     HWFGEEAFGW"
     CDS             complement(6015..6782)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_32"
                     /sec_met_domain="F420_oxidored (E-value: 4.9e-09, bitscore:
                     28.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVIPEEIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAGSMPISVFEGLTARY
                     GVVYPLQTFSKSREVDFKKIPFFLEANSSEDEKVLGEVARALSSDVRFLSSEKRKNLHL
                     AAVFACNFTNHMYALAEKILEEQQIPGEVLLPLIDETAAKAHVMSPAQAQTGPAIRYDE
                     NVINKHMAMLKDPDMRNLYELISRSIHKEARHE"
     CDS             complement(6779..7339)
                     /locus_tag="ctg21_33"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEVDSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKETGE"
     CDS             7461..9872
                     /locus_tag="ctg21_34"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISVIYSCLGYNKAERIIPSAQADMRLNVQMNNTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKDNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPDDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRRVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRGFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             10001..10411
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_35"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.3e-26, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             10448..12001
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_36"
                     /sec_met_domain="CT_Btheta (E-value: 5e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             12023..12916
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_37"
                     /sec_met_domain="OAD_gamma (E-value: 7.9e-13, bitscore:
                     40.9, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLLMVLFNMGAKAQLTTSVKLNEVLVVNEDNFVDDY
                     GKRHPWFELFNNSAGTVDLRGCFLTNDKSNPRKYMIPKGDVLTKVPPRQHLLFWADDQP
                     TKGTFHVNFTFDPNKDNYLALYDSDGTTLIDEVTIPAGQKADVSYGLDLDGVGNWSILD
                     KVTPSTNNLTLDSNAKLENFQRNDPWGIGMTITAMAVVFLGLIILYLVFKQIGNAAIKA
                     SKRNAQKAAGTGAAVSANIGQESGEIFAAIATALYEMSDDNHDIENTVLTIHKVQRSYS
                     PWSSKLYSLRQTPNKK"
     CDS             12940..13371
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.7; E-value:
                     3.5e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_38"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.4e-20, bitscore:
                     63.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNTYKVHINSVVDDVAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTNASGEPVITRQAAPSVAGAVKSPLPGVILSVDCKVGDTVKRGQKILV
                     LEAMKMENNINADRDGKIVEIKVNKGDSVLEGADLVVIG"
     CDS             13376..14536
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg21_39"
                     /sec_met_domain="OAD_beta (E-value: 3.1e-153, bitscore:
                     501.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLQFLGENIQIFLSYTGFANATPGHIVMLLVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQLGIYEEGSVLNILYQGVKQGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYIIALQMGFDPSQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERVIRMKPPRAVSQTEKIVFP
                     IVGLLLTAFLVPSGLPLLGMLFFGNLIKESGVTRRLAETARGPLIDVITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKFFNLFLKEGNKINPLIGNSGVSAVP
                     DAARISQNVGLEYDPSNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(14603..14749)
                     /locus_tag="ctg21_40"
                     /transl_table=11
                     /translation="MRKKSVNTLLVFGVVVAIILLMIWLFLGTTLVEDTSTEISPVPIE
                     QAN"
     CDS             complement(14818..15534)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_41"
                     /sec_met_domain="Peptidase_M22 (E-value: 1.6e-27, bitscore:
                     88.7, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLILNIETSTSVCSVALSEGEEVVFEKASFEGPSHAALLGVYME
                     EALEAAKSKGIKLDAVAVSSGPGSYTGLRIGVSVAKGLCFGYGIPLIGIHTLDILASAA
                     IRKNKEEADCLYCAMLDARRMEVYSSIYDSHLNTIRATTADIVDADSYASFLENGKVCF
                     FGDGAAKCETVITSPNACFIDGIYPLAVNMASLSQKAYDDGRFENVAYFEPFYLKEFQA
                     TIAKNKVLNEALGKNK"
     CDS             15736..16596
                     /locus_tag="ctg21_42"
                     /transl_table=11
                     /translation="MTGFGKVTAELPSKKVTVEIKALNSKQLDLSTRIPSIYKDKEMEL
                     RSLLLQSLERGKVEFNIFIEYIGKDTPTQINLAAVENYYNQIKEIAEKLNISVPNDWFQ
                     TLLRMPDAIKSETVEPDESEWEVVLETVKDAIKHLCDFRIQEGAMLQKLFEQKIANIAT
                     LLKEVEKYEGERIEKIKARIMDNLQKIAEKDYDKNRFEQEMIYYIEKLDVNEEKNRLDN
                     HLKYFISTMESGHGQGKKLGFIAQEMGREINTLGSKSNHAEMQKIVVQMKDELEQIKEQ
                     VLNVL"
     CDS             16611..17177
                     /locus_tag="ctg21_43"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTE
                     KNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYYGTLKSEVERILNEGDNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQFD
                     KVVVNDDLETAQKDALKIIREFLNK"
     CDS             17181..17360
                     /locus_tag="ctg21_44"
                     /transl_table=11
                     /translation="MPNIFKNTRFMMGLSIVCGIASLVLGGISLYYKEYIIGGALIFNI
                     FICFINYKGWQKKG"
     CDS             17372..17947
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_45"
                     /sec_met_domain="CTP_transf_like (E-value: 5.8e-25,
                     bitscore: 80.1, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLKIGIYSGSFNPIHIGHLALANWLCEFEGLNEVWFVVTPHNPL
                     KKKDDLLDDSLRLEMAQAAIDGYPKFKVCDIEFHLPKPSYSIDTLRALSSNYPDRDFYF
                     IMGADNWLLFPRWKEYEKILQNYKLLIYPRLGFDISIPTIYPNVKKVDAPLMEISSTFI
                     RNAYQTGKDIRFFLPEGVRPYFGSVANQ"
     CDS             18428..18676
                     /locus_tag="ctg21_46"
                     /transl_table=11
                     /translation="MNSLYMVEGVIGAVGGAIFVQTNKYLQAGMENEDFYGWGLEDGER
                     HYRWLSFGYRIYGVRAVYSICLIPGIKTGCKDKIIGS"
     CDS             18857..20587
                     /locus_tag="ctg21_47"
                     /transl_table=11
                     /translation="MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKET
                     FKDDAEPRPVSIAGRIMSRRIMGKASFMELQDSEGRIQVYISRDDICPDENKDTYNVVF
                     KKLLDIGDFVGIKGFVFRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFNDPE
                     LRYRQRYVDLVVNDGVKDIFMKRAAIIKTMRTALDEAGYTEVETPILQSIAGGASARPF
                     TTHHNSLDIDLYLRIATELYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYV
                     QYKDYNWMMSFTEKLLERICIAVNGTSKSTIDGKTISFKAPFRRLPILEAIKEKTGYDL
                     EGKSEDEIRTICKELKMEIDDTMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTK
                     MHRSKPGLTERFELMVNGKELANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDF
                     LRALQFGMPPTSGIGIGIDRLVMLMTGQTTIQEVLLFPQMRPEKTAKKDNADKYVALGI
                     SEEWVPALQKAGYLTVDTLKEANANKLRQELCELNKKYKLELQNPTIQEIEAWIANVGE
                     "
     CDS             20600..21595
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_Gly3P_dh_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg21_48"
                     /sec_met_domain="F420_oxidored (E-value: 1.8e-09, bitscore:
                     30.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_Gly3P_dh_N (E-value: 4.1e-35,
                     bitscore: 113.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLPGKIAIMGGGSWATALAKIVLSTQDSINWYMRRPDRIEEFKQ
                     LGHNPCYLTAVKFDTNKINFYSNINQAIKDSDTLIFATPSPFLKQHLKKVKTSLKDKFI
                     ISAIKGIVPDENMLITDYFAEYYKVPTENIAVIGGPCHAEEIALERLSYITLACSDIEK
                     VRTISPVFKNQYLKNSFCKDVTGIEYAAVLKNVYAIAAGICHGMKYGDNFQAVFISNAI
                     EEMRNFVDAVHGLERDITDSVYLGDLLVTAYSRFSRNRTFGTMIGKGYSVKTAQLEMEM
                     IAEGYYGTKCMREINEKYKVNMPILDAVYDILYEKKSPTTVIRQLTETFK"
     CDS             21604..22947
                     /locus_tag="ctg21_49"
                     /transl_table=11
                     /translation="MKNISLNIDKALGTVSKEQVYAQEAKAMECIATLHNGNGAGNDFL
                     GWLHLPSSITDTELADIENTANVLRSKCEVVVAIGIGGSYLGTKAVVEALNNSFDWLQN
                     DRKNPVMLYAGHNIGEDYLYELSEVLKGKQFGIINISKSGTTTEPALAFRILKKQLEDA
                     VGKEEAKHRIVAITDAKRGALRTLADQESYKTFIIPDNVGGRFSVLTPVGLLPIAVAGI
                     SIRDLVAGAVSMEKATDASVPFADNMAAIYAATRNELYKSGKKIEILANFHPKLHYIAE
                     WWKQLYGESEGKDGKGIFPASVDLTTDLHSMGQWIQDGERTIFETVISVEATDHSVLVP
                     TDEADLDGLNFLAGKHVDEVNKMAELGTQLAHVDGGVPNIKVTMPEVSAFYIGQLFYFF
                     EKACGISGYMLGVNPFNQPGVEAYKKNMFALLNKPGYEKESEAIKARL"
     CDS             complement(23018..23263)
                     /locus_tag="ctg21_50"
                     /transl_table=11
                     /translation="VEETGLPKNVVRTVVNALPTVVAKGIREGESISMKGFGSFVPWQQ
                     SERLARNPKTGEEVMITPRVSVKFKAGSDLLKELNE"
ORIGIN
        1 aaagatatga cccgttgtct aagacgatcc ccacgaaatt attcaacgcg acagctcgta
       61 aattctcggg aataaagaac ttacacgatt tcaattgcgg attgaaagcg tataagaatg
      121 ttgtcattaa aaatatagag gtgtataacg atatgcaccg ttacatacct tatttagcta
      181 agattgccgg atttcacaag attggcgaga aagtagtgaa acatcaagcc cgcaagtacg
      241 gaactactaa attcgggttg gatcgcttcg tgaacggtta tcttgatttg atcacgcttt
      301 ggtttacttc caaattcgga aagaaaccga tgcacttctt cggtttatgg ggaagcgcta
      361 tgttcttcat tggttttatc gctctagtaa tcgtactcag catgaaattg atctcgatgt
      421 actctggaga tctaagacct ttggttacaa gttcccctta tttctatatt tcattgacag
      481 cgatgattct gggaacccag atgttcctag cgggctttat cggggagttg atttcccgca
      541 attctccgaa tcgcaataac tataaaatag aggatgagat atgagtttcc tagaattagc
      601 gagaaaacgt tgctctatcc gaaagtatgc ccccaaaaac gtagagcaag aaaagattga
      661 ttatatccta gaagcagctc gtttggcccc ttcggcggta aattatcaac cttggtattt
      721 tgtatgggtt caaagtgcgg aaggaaaagc taaattacaa gaatgctatc cccgggaatg
      781 gttcaagcaa gcgccttatt acttgatcgt ttgcggagat catcagcaat cttggaaacg
      841 gggcgatcat aaggatcata tggatatcga tacggctatc gccacggaac acatttgttt
      901 agccgctgcc gaacaaggat tgggtacttg ttgggtttgc aatttcgaca cggagctttg
      961 ccgtaaacat tttaaaattc cggaaacgat cgagcctgtt gtactgatac cgttcggcta
     1021 tccttccgac ccggcattat tcgatgagac tccaaagaaa cgtaagccca tagaagaaat
     1081 tattaaacgg gaatcattct agtatgttat acattgaagt tctgctacta gcgatcggct
     1141 tatccatgga tagcctagca gtatcagtta ccggcggcgc agttcttaag aacaactgca
     1201 ccgccggtaa tattattaag atagcgagcg tgctcggtat attccaagcc ggaatgaccg
     1261 tgattggtta tacgatggga ttaggattcg aaaaatacat ttgcgccttc gatcattgga
     1321 tcgcatttac cctcttgctt tacttaggtg gaaaaatgat atacgatagc acgaaggaag
     1381 aggaggaaga cgggaaattc gatcctctat gtaaccggac attatgcgga ttgggaatag
     1441 cgacaagtat cgatgccctc gccgtaggaa tctctctggc gatcttaaaa tcaccgctct
     1501 tgctgcaagc ctcgactatc ggtgttgtca ccttcgctat ctctgccttc ggcgtctatt
     1561 tcggtaaccg attcggcaag agaatcgact tgaagctgga cctcatcgga ggtttaatct
     1621 taatcggtat cggtacaaag attttgatag agcatgtatt ctttagctag ggatacctta
     1681 ttgaataaat aaccttatac attaattaat agacatgaaa agccagcaat tacgaaaact
     1741 agcgccggag ctggattcac tccggctagg cagcggttgg aaaatcgacg aattgagtaa
     1801 accgcaaatc attgtagaaa gcagttacgg acatagccat ccgggaagcg cccatctgga
     1861 taaattgatg gacgaggccg gaatcggtat aaaggaaaag gggggacgtg ccgcaaacta
     1921 cttcgtcact gatatttgtg atggagaggc gcagggacac gatggtatga actactcatt
     1981 agtctcccgt gatatcatgg ccgccatgat ggagattcat gtaaaagcga ctcctttcga
     2041 cgctggtgtc tttatagcca gttgcgacaa atccgtccct gcgcatttga tggcgatagc
     2101 ccggctagat atgcctgcta tattcatgcc tggtggtata atgaaagccg gtcccaacct
     2161 actcacgtta gaacaaatcg gtacctatag cgcccagtac gagcgaaaag aaataacgga
     2221 agaacaattc atggtttata agcgtgacgc atgtccggat tgtggagctt gctctttcat
     2281 gggtaccgcc tctacaatgc aagtaatggc agaagcgctt ggcatcgctt taccgggctc
     2341 cgccttgatc cccgcccatt tacccgagtt aaaagaaacc gcccgtaaag ccggagaaca
     2401 tgcactcgga ctggcgaaag aagagttaaa accctccgat atcatgacga tacaagcgtt
     2461 tgaaaatgcg atcatggtac atgccgccat agcgggttcc agcaacagcc tgcttcatct
     2521 tccagctatc gcccatgaac tgggaatcca gttatcaccg gatttgttcg acaagataca
     2581 tcgtaagatc ccctaccttt taaatatacg tcccagcggt ttttggcccg gcgaatattt
     2641 ctggtatgcg ggaggcgtac cggcgatcat ggaagaaatc aaagaattcc tccatctcga
     2701 cgtcatgact gttaccggca aaacattgga agaaaactta aaagatttac aactcaacgg
     2761 cttctatgag aattgccata aatatcttcc tgccctagga gtaaaggttg gcgatattat
     2821 caaacctttt catacaccga tcaaggcaca aggagccatc gctatattga aaggaaattt
     2881 agcgcccgaa ggggcagtcg taaaacattc ggcgatttca ccccgcttga tgcaagtcac
     2941 cctgaaagcg agggtattcg attgtgagga gaacgctatt gaggcggtat tacaaaagaa
     3001 aatccatccg ggagaagcgg tatttatccg ttatgaagga ccgaaaggaa gtggaatgcc
     3061 agaaatgttt tatacgacag aagcgatcgc ctccgatcct gagttggtag agaccatcgc
     3121 attgatcacc gacggtcgtt tctccggagc gacccgaggc ccggcgatcg gacatgtatc
     3181 cccggaggct tccgaggggg gaccaatcgc cttggtcgaa aacgatgact tgatccgtat
     3241 cgatattcca gcgagaacat tggatataat cggtaccgac agtattgaga gaagcgtgga
     3301 agagatagaa aagatcctat ccgaaaggcg tgcacattgg ataaaaccag agtcacaata
     3361 taaaaaagga atccttgata tttatacaca caacagcgtc tcccccatga aaggggcata
     3421 tatggaattt tttatgtaag ttcgcgacat aaaatttcat aatgatgcgc aagaatatta
     3481 ccatattagt cagcctgttg atcttatcgc atacggcttg ctcggacaag ggccaatatt
     3541 tcgaagagag tggttctgtt tttcatacaa gttaccacat caaatacaag gccaagcaaa
     3601 tcctaaccga taagatcgac agcgagctgc aacgttttaa cctctcctta aatcctttca
     3661 accccaactc cacgatcgcg aaagtcaata ataacgagga tgtggaggta gacgaatggt
     3721 ttaccgaagt attcaataag gcggaagaaa tctcccaaaa atcaggagga gcttttgata
     3781 ttacttgtgc tccattaatt aatctatggg gattcggatt cagtaagatg gatagcgtaa
     3841 ccccgcagat gatcgatagc ataaaggctt tcgtcggtta tcaaaaagtg agattggaag
     3901 gaaagaaaat catcaaagaa gatccccgga ttctattgaa ttgttcgtcc atcgcaaaag
     3961 gttatgcttg cgatgtcatc gcccgcctgc tggaaaagga aggcgtaaag aactacatgg
     4021 tagaaatagg tggtgaggtc accatgaaag gcgtaaatca acaaggtgac tgttggcgag
     4081 tcggcatcaa caagccggaa atagggacaa gtggcgtaac aaatgatgtt gaagagatcg
     4141 tacaattatg ccaaaaaggg ggtgtggcta cttctggtga ctaccgaaac ttctacatca
     4201 aggatggtaa gaaatatgcc catacgatca atccggcgac cggttatccc gctggacaaa
     4261 atattcttag cgcgaccatc gtggcggaag attgtatgac agcagacgct tacgctacga
     4321 ctttcatggt tttgggagtc gagaaagcga agctactggc acaatccatc ccccaaatag
     4381 agtattttat tatttatgcg gacaacaacg gacaacagaa agtcacctac tcaaaaggta
     4441 tgttggaata ccttcctaac agaaaaacat tggctatcct cgaaaatcct taagttccta
     4501 catgaagcgt tatctaaatc aacttgaatg caaaatactg agagccggag attccctgtt
     4561 taataccaca accacggata atctattaat cttcgtattt tcgggaaaac ttattattta
     4621 cagccaagaa gggacacata tagcggaagt ggcaaaagat catttcatgc tacttgcgca
     4681 aaacaccaat cataaggtta tagcctcaac ccctacccgc cttatcttaa tacatgcggg
     4741 cagcttatcc gacatgatca taaatgaccc ggaatggaat gtggagaaac cggtcgtctt
     4801 accgattccc ccagccttag cgcacacatt aaatcagata gaatattata tgaaggataa
     4861 atactttacc ttgaattgag attaaaaatg tttcaattcc tgataaagct tttgcacagg
     4921 taatcccatc acgttataaa agctaccatt gatagcctct accccgatat aaccgatcca
     4981 ctcctgaatg ccataccctc ccgctttatc ataaggttta tatttatcca aataataatt
     5041 aatctcttca tcacccaatt ttgcgaaaca aaccgcagat tcgacggaaa agcctacatt
     5101 tttgtccttc gtcatgatac aaacgccggt tattacctga tgtacatgat ccgacaaagc
     5161 atgaagcata gcataagctt cctcccggtt cgcaggcttc cccataaccc cgtcaaacgt
     5221 ccaaacgatc gtatctgccg tgattagcaa ttcatcatcc gccatagtcg atttataggc
     5281 ctccgctttc gaacgggcaa tatataaagg gatctccatg gagtcaatag aatccgggta
     5341 agactcgtca atatccggaa ttatcctcac ctcgaagtcg atatccagac cagataacaa
     5401 attccgtcgt ctcggagaat tagaggctaa gacgatcttg tactttttta aattctctaa
     5461 cataacctat tcgattaagc gttacacatt caccaaaatt ttaccaccca aaagcctcct
     5521 cgccgaacca gtgtccttgc gcccgcatcg tttgctcgat cacgtcccta gctacgcctt
     5581 cgccacctcg ccgggaggat atatatttcg ctatctcctt gatctccgga gccgcatccg
     5641 caggtgccac cggcaatccg actcgcgtca ttacctcata atcaggaata tcatcacccg
     5701 catacatgat ttgctcagga gacaagcccg ttttttccat gaaatcctta aagtcatgca
     5761 cctttacagc gctacgcata taaatatgct gtatacccaa acgagaaaag cgaatctgta
     5821 cggcttccgt atatccgccc gtaattatag cgacctcata acctttcttc acggccaatt
     5881 gcaaggcata gccatccttg atattgaccg tacgcatcgg atctccattc gggtgaagcg
     5941 gaatcacatc gcaggatagc accccgtcta catcaaagac aaaagccttt atttttctca
     6001 aatcatagtt tatactactc atgtcgagcc tccttatgta tacttcggct aatcagctca
     6061 tatagatttc gcatatccgg atctttaagc atagccatat gtttgtttat cacattctcg
     6121 tcatatcgta tagctggtcc cgtttgggct tgcgccggcg acattacatg tgccttagcg
     6181 gctgtctcgt ctatcaaagg tagcaagacc tctcccggta tttgctgttc ttccaagatc
     6241 ttttcagcta gcgcatacat atgattcgta aaattacaag cgaaaaccgc cgctaaatgt
     6301 aagttctttc gcttctcgga ggagaggaaa cggacatcac tggagagcgc cctagccacc
     6361 tctcccagca ccttctcatc ttcagacgag ttcgcctcta aaaagaacgg tattttcttg
     6421 aaatccacct ccctactctt actaaacgtt tgtaacggat aaaccacccc atatctagcc
     6481 gtaagacctt caaatacaga gattggcata ctccctgccg tatgcaccca caaaccgtta
     6541 ttcggtttta cacgggcgat aacatcttgg agcacggcat ctttcaaaga gaaaacatac
     6601 aagtcggcat cttccacaat ctcttccggg atcacggtcc acccacatcc caattcatca
     6661 gctaaaatct tagcatgctc acttgtgtga ctatatactt gcccgatact cattccggac
     6721 ttacgcattt ccaacgaaag ccgggtagct aagtttccgg caccaacaaa tacgactctc
     6781 attctcccgt ctctttattt tcttccggaa gagagaactt tcctatatgt atcttctccc
     6841 attgtaaatg ggattcatca aaaggcttac gaacctgatc cttataaccg ataccaatga
     6901 tagacaagac atccaattga taagggatat ccagcaacga acgaacataa ttattcgaat
     6961 ccacctcgtc ctctgttacc cggttccgga tctgacacca gcaactgccc agtcccaaat
     7021 cctccgcttg caattgcata taaatagaag cgaccgaagc gtcctcgatc caaacatcgc
     7081 tttccatcac attcgccaag acaaccacgg ccaaggcaca accctccaga aaagcggaac
     7141 catttttctt acacccggca agtttcttca acatttcctt atcttccacg accacgaact
     7201 gccaaggatt actacgtttt gaggccggag ccatcaacgc cgccttcaag atcagttcta
     7261 cctgctcggg tgaaagtagt tgttcggtaa acttacgtgt acttcttcta ttttgtataa
     7321 gtgttgcaaa actctccatt tttttcgttc tttgtactct tttaatatta agattcgcaa
     7381 atataaatat aattttttgc acccatatat acgtatcgtt cttttttctc gttagtattt
     7441 ttataattga acaatagatt atgaagattc gtgcgatagc tgcgctgcta tttatactta
     7501 tttccgtgag tgcctttggc gagggccgca taaaaatcac tggttatgtc cgtgacgccg
     7561 acggtaaccc tctggaatta gtgaatgtcc gggttaagaa cacgttgatc ggctccatga
     7621 ccaacgagaa gggatattat tccttttcca tatcgccggg ggattctatc tccgttattt
     7681 actcttgtct gggatataat aaggctgagc gtatcattcc ctcggcacaa gcggatatgc
     7741 gcctgaacgt acagatgaac aatacctcat ttgatttagg ggaagtatcc gttactgcca
     7801 tccgcaagca gaccacgacc atggagtccc taaatgcgga caaaattaag ttattgcccg
     7861 atccctccgg aggtagtata gagagcttgg tcgttacgtt tgccggagta tcgtccaata
     7921 acgagttaag ttcccagtat tccgtacgtg gaggtagtta tgatgaaaat atcgtttatg
     7981 tgaatgggat cgaggtattc cgtccgcttc tgattcgctc gggacaacaa gagggcctta
     8041 gctttatcaa tccggacctg acggaggcgg tcaatttcgc cgccggtggc ttcgaggctc
     8101 gttacggaga caagatgagt tccgtgctgg atattaccta taaaaagcct aagatattcg
     8161 aaggctcggc ttccgcaagc ttgttgggcg cgaatgctta tgtaggcagt tctatcggta
     8221 aatttaccca agtaacgggt ttccgcttta aaagcggtcg gtctattttg ggtaccatgg
     8281 atacagacgc agaatacgac cctaaattta tcgatctgca aacttacatc acgtaccaat
     8341 tggcccctaa atgggaaatc aatttcttgg gaaacctcgc taacaataat tataaattca
     8401 ccccttatag ccgggaaacc tctttcggta cagccgagca tcccaagaac ttcaaagtct
     8461 atttcgacgg aagggaaaga gaccgtttcc aaaccttatt cggtgcgctt acattgaaag
     8521 acaaccccaa tgagaacaca gagttgggac ttcaagcctc cgctttcaaa agcaaggaag
     8581 aagagggata cgatatcgcc ggagaatatt ggctaagcga gaacggagcg gaaaatccgg
     8641 atgacgacgc gtcagccgcc atgtccgtag gccgttatca cgagcacgca cgaaaccgtt
     8701 tgaactccac cgtcatgaat gtcgggcact atgggatggc ccgcctttta aacaatacgt
     8761 tgaaatgggg agccacggta caaatggaga aaatcaatga taagatcagt gaatgggaaa
     8821 aaagggattc ctcaggttat tctttgcccc aaaccggtaa taacgtaagt gtatattcga
     8881 acctcttttc tgataatcag atagaaagca cacgcttttc cgcttatgcg caagacgcgt
     8941 tcaaattcag gaccaagcaa ggtctgttca cgttagtcgc aggggttaga ggtagttatt
     9001 ggacttataa taaggagttc cttttcagtc cccgtgcctc attgggcttt atcccgaact
     9061 tcgaccaaga cttgacgctc cgtttcgcca ccggactgta ttatcaatcg cccttctaca
     9121 aggaattacg tagagtagac aaagataaga acggcaataa tatcacggta ttgaacaaag
     9181 atctaaagtc acaacgctcc atccatttca tattgggagg agattatacg ttccgtgccg
     9241 tagaccggaa tttcaaggtg accgccgaga tgtactataa aaagctggac aatctgaatc
     9301 cctacaccgt agataacgtc aagatccgct attacggcga gaactgcgcc aaaggttacg
     9361 ccatgggact cgatgtcaaa ttcttcggag aattcgtacc gggtaccgac tcatggatca
     9421 gcttctcctt gatgaaagcc cagcaaacca tccgggaaac aacgaccgtt cctatggcca
     9481 atagccaagg ctacaacatc tcactcttct tccaagatta tttcccgggc tataaacgag
     9541 tcaagctaaa tctgaaagga gttctatccg gaggacttcc ccagacaatc ccgggcaaag
     9601 gatacgaagc cggctatttc cgtacgcccg cctacaaacg tgtagatatc ggcctctcct
     9661 atcaattggc aggaggcacg gacgctatca tggacagggg cttcttccgc catttgaaaa
     9721 acatttggct aggtctggat gtatttaaca tattagacat caaaaacgtt agttcctact
     9781 attggataac agatgtatat aatgtccaat acgcagttcc aaactatctg accggacgtc
     9841 aattgaacgt tcgtctgatt gtcgattttt aataaaatgt atctttaaac acatttactg
     9901 ggagataaaa acaaaaaatt atttcctcat tcataaaaag tagtgtacat ttgcacacaa
     9961 tagaaacaaa catttactaa atctttaaat tattattgac atggaactta cacatatcga
    10021 acatttaggt atcgcagtga agagtatcga ggcttgttta ccctattatg aaggcgttct
    10081 tggattaaaa tgctacaata tcgaagtagt agcagaccaa aaagtaaaaa ccgcattttt
    10141 caaggtagga cagactaaga ttgaattact agagccgacc agcgaagata gcacgatcgc
    10201 aaaatttatc gagaaaaaag gtgaaggtat ccaccatatc gcattcgcgg tacctgatgt
    10261 acaggcagct ttgaacgagg ctgaggaaaa aggcgttaaa ttaatcgata aagctccccg
    10321 tggtggcgcg gaaggcttga acatcgcttt ccttcacccg aaatcaactt gcagcgtatt
    10381 gacagagctt tgcatgccgg gcaacaaata attaatccgt tcatttctaa caacaaatca
    10441 aaatacaatg agtaaccagc ttgaaaaagt aaaagagctc atcgcacttc gtgagcaagc
    10501 tcgcttgggt ggaggagaga aaagaatcga atcacagcac aaaaaaggca aatataccgc
    10561 tcgtgagcgt atcgccatgt tgcttgacga aggtagtttc gaggaattcg acatgtttgt
    10621 tcaacaccgt tgtacaaact tcggtatcga gaaaactaaa tatttaggcg atggtatcgt
    10681 aacaggttat ggtacgatcg acggacgttt ggtatatatc ttcgctcaag atttcaccgt
    10741 attcggtgga gccttgtctg aggctttggc tatgaagatc tgtaaagtaa tggatcaagc
    10801 catgaagatg ggcgctcccg ttatcggttt gaacgactcc ggtggagctc gtatccaaga
    10861 aggtgtaaac gccttggcag gatacgcaga gattttccaa cgtaacatct tggcttccgg
    10921 tgttgttccc cagatttccg gtatcttcgg cccttgcgcc ggtggagccg tttattctcc
    10981 ggctttgaca gacttcaaca tcatgacacg tggtaccagc tatatgttct tgactggtcc
    11041 gaaagtcgta aaaaccgtaa caggtgagga tgtaacccaa gagcagttgg gtggagccag
    11101 cgtacacact accaaatcgg gtgtagccca tttcgctgtc gatacagaag aagatggttt
    11161 gcaattgatc cgtaaattgc tcagtttctt acctcagaac aacttagagg aaacgccgtt
    11221 agttgagtgc aaagacccga tcgatcgtct ggatgatgta ttgaacgata tcattcccga
    11281 taacgccaac caatcttacg atatgtatga ggttatcggt acgatcgtcg ataacaacga
    11341 gttcctagag gtccatgcgg actacgctaa gaatatcatc gtaggtttcg ctcgtttcaa
    11401 cggacaatcc gtcggtatcg tagctaacca gccgaaggtt atggcaggat gcttggatag
    11461 caacgcatct cgtaaagcag gtcgcttcgt tcgtttctgc gacgctttca atattccttt
    11521 ggtaacattg gttgacgttc cgggattcct tccgggtaca ggtcaggaat acaacggtgt
    11581 aatccttcat ggcgctaaat tgctttacgc ttatggtgag gctaccgttc ctaagattac
    11641 cgttacattg cgtaagtctt acggtggagc ttattgcgtg atgagttcta aacatttacg
    11701 tggtgatatg aattacgcat ggccgacagc cgagatcgcc gttatgggcc cgagcggtgc
    11761 cgtagaggtt atcttcgcca aggaagtagc agccgctgaa gatccgaaag catgcgcagc
    11821 agagaaagaa gctgaatata agaaagcatt cgctaatcct tataacgcag ctcaatacgg
    11881 ttatatcgac gatgttatcg aaccgcgtaa cactcgtttc cgtattattc gtgctttgca
    11941 gcaattgcag actaagaagt taagcaatcc tgctaagaaa catgataacc tgcctctata
    12001 atccgtaaaa caggagatga atatgataaa taagaaaata ggggtattgc tactgttaat
    12061 ggttctcttc aatatgggag ccaaggcaca gttgactacc tccgttaaat taaatgaagt
    12121 gctagttgtc aatgaagata actttgttga tgactatgga aaacgccatc catggtttga
    12181 gttatttaat aactcagcag gtacggtgga tttacgagga tgcttcttaa cgaacgataa
    12241 aagtaatccc agaaaatata tgatcccgaa gggagatgta cttaccaaag ttcctccccg
    12301 ccagcatctt cttttttggg cagatgatca gccaacaaaa gggacatttc atgtaaactt
    12361 cacattcgat ccaaacaaag ataattatct agccttatat gattcagatg gtacaacttt
    12421 gatcgacgag gtgacaatcc ctgccgggca aaaagcagat gttagttacg gtctggatct
    12481 tgatggagta ggaaattgga gtatccttga caaagtgact cctagcacca ataatctgac
    12541 gttagattcg aatgcgaaac ttgagaactt ccaacggaac gacccatggg gtattggtat
    12601 gaccataaca gccatggcag tcgtattcct tggcttaatc attttgtatc tagtattcaa
    12661 gcagatcggt aacgcagcga tcaaagctag caagcgtaac gctcaaaaag ccgcaggaac
    12721 aggtgctgcc gtatcagcca atatcggtca agaatcaggt gaaatttttg ccgctatcgc
    12781 taccgctctt tatgagatga gcgatgacaa ccacgatatc gagaacacgg tattgactat
    12841 ccacaaggtt caacgcagct attcaccatg gagttctaag ctttattctc tgcgtcagac
    12901 tccaaataaa aagtaatcat cctaaaatcc aattgacgaa tgaaaagttt taaatatacc
    12961 attaacggta acacatataa agtacatatc aactcagttg tagatgatgt ggcagaggta
    13021 gaggtaaacg gaacccctta taacgtaaaa atggagaaac ctgcgaaaaa acaaatggtt
    13081 acattgaaac gtccggctca agctccgacc aatgccagcg gtgaacctgt tatcacccgt
    13141 caagcagctc caagtgtagc cggcgctgtt aaatctccgc tgccaggtgt aattttaagt
    13201 gtagactgta aagtcggcga tacagttaag agaggccaaa agatcttggt attggaagcc
    13261 atgaagatgg aaaacaacat caatgccgat cgtgacggta aaattgtaga aattaaagta
    13321 aacaaaggcg actctgtatt ggaaggtgca gatctcgttg taatcggtta atgatatgca
    13381 agaaagtttc ttacaattcc taggagaaaa tatccaaata tttctctcct atacaggatt
    13441 tgcgaacgcg actccagggc atatcgtgat gctattggta ggtttgctgt tcatattcct
    13501 agcgattaaa tatgaattcg agccaatgct tctgatccct attggtttcg gtatcttgat
    13561 cggaaatatc cctttcaagg atgccggatt acaattaggt atatacgaag agggttctgt
    13621 attgaacatt ttataccaag gagtgaaaca aggttggtat ccccccttga tattcctcgg
    13681 tatcggtgcc atgacagact tctccgcttt gatatccaat cctaagttaa tgctagtcgg
    13741 agctgccgcc caatttggta ttttcggtgc ttatatcatt gcattgcaaa tgggatttga
    13801 cccgagccaa gccggtgcta tcggtattat cggaggagct gatggtccaa ccgcaatctt
    13861 cttgtcatcc aagttagctc ctaacttgat gggtgctatc gctgtatccg catactcata
    13921 tatggcattg gttcctatta tccagccacc gtttatgaga ttgcttacaa cgaagaaaga
    13981 acgtgtgata cgtatgaaac ctccaagagc cgtttcacag acggagaaaa tcgttttccc
    14041 gatcgttggc ttgctattga cagccttctt ggtaccgtct ggtttgccat tgttaggaat
    14101 gttgttcttc ggtaacttga tcaaggaaag tggtgttact cgccgtttgg cagagacagc
    14161 ccgcggcccg ctgatcgatg ttattacgat cttgttaggc atcacggtag gtgcttctac
    14221 acaagctacc cagttcttaa cattgaactc tatcaagatt ttcggtttgg gtgcgttgtc
    14281 attcgttatc gctacttgtg ccggtgtatt gttcgttaag ttctttaacc tgttcttgaa
    14341 agaaggcaac aagatcaatc cgttgatcgg taactccggt gtatccgccg tacctgacgc
    14401 tgcccgtatt tcccagaacg taggtttgga atacgatcca agcaactact tgttgatgca
    14461 cgctatgggt ccaaacgtag caggtgtaat cggttccgct gtagctgccg gtatcttgct
    14521 aggattcctt ggttaataaa acaactatct atattaaaaa aggcgaggtc cgaaaggatc
    14581 ccgccttttt atgttattgt tctcagttag cttgctctat aggaaccgga ctaatctccg
    14641 tactcgtatc ctccaccaac gttgtcccga ggaacaacca gatcatcaaa aggattatag
    14701 cgacaaccac accaaatacc aatagcgtat tcacactttt ctttctcatg tctttaactg
    14761 atttattcat tttagaataa acagccggaa catgaatttg gttgtgtact cttactctta
    14821 tttgtttttc cctaacgcct cgttcagcac tttgttctta gcgatcgttg cttggaattc
    14881 tttcaagtag aaaggctcaa aataagccac attctcaaaa cggccatcat catatgcttt
    14941 ctgcgacaag gatgccatat ttacagctaa tggatagata ccatctataa aacaggcgtt
    15001 cggagaagtg attaccgtct cacatttagc ggcaccgtct ccaaagaaac aaaccttacc
    15061 gttctctaaa aaagaagcat acgaatcagc atctacgata tcagcagtcg tggcacgtat
    15121 cgtgttgaga tgggaatcat aaatcgaaga gtagacttcc atacgacggg catccaacat
    15181 agcgcaatac aagcaatcgg cctcctcctt atttttccga atagcggcag acgctaaaat
    15241 atccagcgta tgaataccga tcaaaggaat accataccca aagcataatc ctttagccac
    15301 agacaccccg atgcgtaacc ccgtataaga tccgggtccg ctacttaccg ccacagcatc
    15361 cagttttatc cctttcgact tcgcagcttc taatgcctct tccatataaa cgcccaataa
    15421 cgccgcatga gacggcccct cgaaggaagc cttctcaaag accacctcct ccccttccga
    15481 cagggctact gaacatacgg aagtggatgt ctcgatattt aagatcaatg acataataat
    15541 taactattaa caattgataa ttgaacgaac aaacaatctc aatccttcaa tctgattagg
    15601 ctgcgaaggt atacaaaaat tcattatgct atcaaggcag ccctatgaga aacatctatt
    15661 tatgagaaaa taaacatcaa atctaaaagg aaaccactat ctttgcgcaa acttttgaga
    15721 aaaatgatac aatcaatgac tgggttcggt aaggttactg ccgagctccc ttcaaaaaaa
    15781 gtaaccgtag agataaaggc tttaaacagt aagcaattgg atttgtccac ccgtatccct
    15841 tccatataca aggataagga aatggagctt cggagcctgt tacttcaatc tttggagcgg
    15901 ggaaaagttg agttcaatat ctttatagaa tatataggca aagatactcc tacacagatc
    15961 aatcttgccg ccgtagagaa ttattacaac caaatcaagg agatcgcaga gaaactgaat
    16021 atcagcgttc cgaacgattg gttccagacc ttgctccgga tgccggacgc aatcaagtct
    16081 gagaccgtag aaccggacga atccgaatgg gaggtggttt tagaaacggt aaaggacgct
    16141 atcaagcacc tgtgtgattt ccgtatccaa gaaggagcca tgcttcaaaa gcttttcgag
    16201 caaaagatag ccaatatcgc cactctgttg aaagaagtgg agaaatacga gggggaacgt
    16261 atcgagaaga tcaaggctcg tatcatggat aacctgcaaa agatagccga gaaggactac
    16321 gacaagaatc gtttcgagca ggagatgatc tattacatag agaagctgga tgtcaacgag
    16381 gaaaagaacc gtctggacaa ccacttgaaa tattttatct caaccatgga atccggtcac
    16441 ggccaaggca agaagctcgg ttttatcgct caggaaatgg ggcgtgagat caatacgctc
    16501 ggatcaaaga gcaaccacgc cgagatgcag aagatcgtgg tccagatgaa agacgagttg
    16561 gaacaaatca aggaacaggt actaaacgta ttataataag attaacgaga atggctggca
    16621 aattaattat cttctccgca ccctcgggtt ccggaaaatc aaccattatt aattatcttt
    16681 tgaaacaaga tttacacctt cgtttctcca tctcggctac cagccgggct ccgcggggaa
    16741 ccgagaagaa tggtgtggaa tattatttcc ttacgccgga agagttccgc agtcgtatcg
    16801 ctaatggaga cttcttggaa tatgaggagg tgtataccga taaatattac ggtacgttaa
    16861 aaagcgaggt agagcgtatc ttgaatgaag gggacaacgt gattttcgat gtggatgtgg
    16921 taggcggatg caatatcaag aaattctatg gagaccgtgc cctgtctgtc tttatccaac
    16981 ctccttgcat cgatgaccta cggaagcgat tggaaggacg gggaacagac agcccggaag
    17041 ttatcgaaag ccgtatcgcc aaggctgagt atgaattagg gttcacggga cagtttgata
    17101 aggttgtcgt aaacgatgat ctggagactg cccaaaaaga cgcgttgaag atcattcgtg
    17161 agttcttaaa caaatagtct atgcctaata tattcaagaa tacccgtttt atgatggggc
    17221 tttctatcgt ttgtgggata gcgagcctcg tattaggtgg tatcagcctg tattataagg
    17281 agtatatcat cgggggtgcc ctgatattta atatattcat ttgttttatc aactataagg
    17341 gttggcaaaa gaaggggtaa gtataaatcg gatgagactc aagatcggca tctacagtgg
    17401 atcgttcaat cccattcaca taggccatct cgccttggcg aactggctat gtgagttcga
    17461 gggactgaat gaggtgtggt tcgtggtcac gcctcataat ccgctgaaga aaaaggatga
    17521 cttgctagat gactcactac ggttggaaat ggcccaagcc gccattgacg gatatccgaa
    17581 attcaaggtc tgcgatattg agttccacct gccgaaacct tcttattcca ttgatacctt
    17641 gcgagcctta tccagcaact atccggatag ggacttttat tttatcatgg gagccgataa
    17701 ctggctgctt tttccccgat ggaaagaata tgaaaaaata ctccaaaact acaaactgct
    17761 gatttatccc cgcctaggat tcgatatctc gatcccaacc atttatccga acgtgaaaaa
    17821 ggtagacgct cccttgatgg aaatctcctc cacatttatc cgtaacgctt accaaaccgg
    17881 caaggatatc cgtttcttcc tgccggaagg agtgcggcct tatttcgggt cagtagcaaa
    17941 tcagtgacat acctgcgata gaagatatac ttacttgggt tatgaagtat atatcctatg
    18001 ccacttgaag tatatattct tcgagaaggg aagttatacc gtgattattt acagctttgc
    18061 catcttaggg caatctgcca aaattcccat taaaacatgt tttacagcac agccgttaaa
    18121 gatgatcccc gtaacatcaa aacaggctca cccgataatc tttttggagt atccaaatat
    18181 ataatttgag ccttgtcaag tgaataacta atggttacac cgaggattac tgaatggttt
    18241 ccccggtgtg atattggcat tgttgaacat taagcaaaga tatttatgcg aatagacttg
    18301 acaagatcta agacatacga ggtagcttat ccatacgatg ggaatgcttt ggacacttca
    18361 aatatattga gggaacatta ctggccacat agagacattg acttcctaaa aaaaacacca
    18421 aagaaaaatg aactctttgt atatggtgga aggagttatt ggggcagtcg gaggagcgat
    18481 ttttgtccaa acgaacaaat atctgcaagc gggtatggaa aatgaggatt tctatggctg
    18541 gggcttggag gacggagaaa gacattaccg ttggttgagt tttggctacc ggatttacgg
    18601 agtgagggct gtttattcca tttgtctcat ccccgggatc aaaacgggat gtaaagataa
    18661 aattattggg tcttaagttc attagcctac aaacctaaga tacttcacca aggatcctaa
    18721 gatactttac cgatgaacct aagatacttt atccatgaac aaacaagatc ggtgacctca
    18781 accttttacc acataagtca gcataaatca gaaatatttt gtacttttgc gccgtattat
    18841 acaaaataat agcataatga atctattaga actgagtgaa caggaaataa taagacgtaa
    18901 tagcatggag cagttgcgtc agatggggat agagccttat cccgcagctg agtatgtaac
    18961 gaacgcattt tccaaagaaa taaaagagac attcaaagac gacgctgagc cacgcccggt
    19021 aagtatcgcc ggccgtatca tgagccgtcg tatcatgggt aaggcttcct tcatggaatt
    19081 gcaggattcc gagggcagaa tacaggtcta tatctcccgt gacgatattt gtccggatga
    19141 gaataaggac acctacaatg tcgttttcaa gaaattactg gatatcggtg atttcgtcgg
    19201 gatcaaggga ttcgttttcc gtactcagat gggagaaatt tccgttcatg ctcaagaatt
    19261 gacagttttg tctaaatcac ttcgtccgct accggtcgtt aaatataagg acggtgtcgc
    19321 ttacgacggt tttaatgacc cggagcttcg ctaccgtcaa cgttacgtgg atttggtagt
    19381 aaacgatggc gtaaaagata ttttcatgaa acgtgcggct atcatcaaga ccatgcgtac
    19441 cgctttggat gaggccggat acacggaggt agagactccg atcctgcaat ctatcgccgg
    19501 aggagctagc gcacgtccgt tcacgacaca tcataactcc ttggacatcg atttatattt
    19561 acgtatcgct accgagttgt atttgaaacg attgatcgtc ggtggattcg agggtgtata
    19621 cgagatcggt aagaatttcc gtaacgaggg tatggaccgt acgcacaacc cggagttcac
    19681 ctgtatggaa ctttatgtcc aatacaagga ctacaactgg atgatgagct tcaccgagaa
    19741 gctgttggag cgtatctgta tcgccgtgaa cggtacgagc aagagcacga tcgacggtaa
    19801 gacaatcagc ttcaaggctc ctttccgccg tttgccgatc ttggaggcga tcaaggaaaa
    19861 gacgggttac gacttggaag gtaagagcga ggacgagatc cgtacgatct gcaaggaatt
    19921 gaagatggag atcgacgata cgatgggtaa aggtaaattg atcgacgaga tcttcgggga
    19981 gttctgcgag ggtacgttta tccagccgac cttcatcatc gactatccgg ttgagatgag
    20041 cccgctgact aagatgcacc gtagcaaacc gggattgacc gaacgcttcg agttgatggt
    20101 aaacgggaag gaattggcga acgcttatag cgagctgaac gatccgatcg accaagaaga
    20161 acgtttcaag gagcaattac gcttgagcga gaaaggggac gacgaggcga tgttcatcga
    20221 tcaagatttc ttacgcgccc ttcaattcgg tatgcctcct acgtcgggta tcggtatcgg
    20281 tatcgaccgt ctggttatgt tgatgaccgg acagacaacg atccaagagg tattgctttt
    20341 cccgcaaatg cgtccggaga aaaccgcaaa gaaagataac gccgacaaat acgtagcctt
    20401 gggtatttcc gaggagtggg ttcccgcttt gcagaaagcc ggctacctga cggttgacac
    20461 gctgaaagaa gcgaacgcca acaaattaag acaagagctt tgtgagctta ataaaaaata
    20521 taagttagaa ctgcaaaatc ctacgatcca agaaatagaa gcttggatag ccaatgtagg
    20581 agaataaaag cgtgatacga tggatttgcc cggaaaaatc gcgataatgg gaggtggtag
    20641 ctgggctacc gccttagcca agatcgtact ttcaactcaa gatagtatca actggtacat
    20701 gcgtaggccc gatcgtatcg aggagttcaa gcagttggga cacaacccgt gttacctcac
    20761 cgccgtgaaa ttcgacacga acaagataaa cttctattcc aatatcaacc aagcgatcaa
    20821 ggactcggat accttgatct tcgctacgcc ttcccctttc ttgaaacaac atttgaagaa
    20881 ggtgaagacc tctttgaaag ataagtttat catctcggcg atcaagggta tcgtaccgga
    20941 tgagaatatg ttgattacgg attacttcgc ggagtattac aaggttccga cagaaaatat
    21001 agcagttatc ggtggtccct gtcatgcgga agagatcgct ctggagcggc tctcgtacat
    21061 tacgttggct tgttccgaca tcgagaaggt ccgtacgata tcccccgttt tcaagaatca
    21121 atacttaaag aattccttct gtaaggatgt gaccggtatc gaatacgccg ccgtactgaa
    21181 gaacgtgtac gctatcgccg ccggtatttg ccatgggatg aaatatggcg ataacttcca
    21241 agccgtattt atctcgaacg ctattgagga gatgcgtaat ttcgtggacg ccgtacacgg
    21301 gctggagcgg gatatcaccg actccgtcta ccttggcgat ttgctggtta ccgcttattc
    21361 ccggttcagc cgtaaccgta ctttcggaac catgatcggt aaaggatatt ccgtgaagac
    21421 agcgcagctg gagatggaaa tgatcgccga gggatattat ggaaccaagt gtatgcgtga
    21481 gatcaacgag aaatataaag tgaacatgcc gatactggac gctgtttatg atatattgta
    21541 cgagaagaaa tcgccaacaa cggtcattcg tcaattaacg gaaacgttta aataaaatag
    21601 catatgaaaa acatcagttt aaacatcgac aaggctctgg gcactgtctc caaggaacag
    21661 gtttacgctc aagaggccaa ggcaatggaa tgtattgcca cattacataa cggtaacgga
    21721 gcaggtaacg actttttggg ttggttgcat ctcccctctt ctatcacgga cacagagttg
    21781 gccgacatcg agaatacggc gaacgtgctt cgttctaaat gtgaagtggt cgtagccatt
    21841 ggtatcggtg gtagctattt gggtaccaaa gcggtagtag aagcgttaaa caacagcttc
    21901 gactggttgc aaaacgaccg taaaaacccg gttatgttat acgccggaca caatatcgga
    21961 gaggattatc tttatgaatt aagcgaagtt ttgaaaggta agcaattcgg tattatcaat
    22021 atctccaagt ctggtacgac tacagagccg gctttggctt tccgtatctt gaagaaacaa
    22081 ttggaagatg ctgttggcaa ggaagaggct aaacatcgta tcgtagctat cacggacgct
    22141 aagagaggcg ctttgcgtac cttggcggat caagaaagtt acaagacttt catcatccct
    22201 gataacgtag gtggacgttt ctctgtttta actccggtag gtttgcttcc gatcgccgtg
    22261 gcaggtatca gcatccgcga cttggttgct ggagctgttt ccatggaaaa agctacagac
    22321 gcgagcgttc ctttcgctga taatatggcc gctatctatg ccgctactcg taacgagttg
    22381 tataagagcg gtaaaaagat tgagatcttg gctaacttcc atccgaaatt gcattatatc
    22441 gcagaatggt ggaaacaact ttatggagag agcgaaggta aagacggtaa aggtattttc
    22501 cccgcatctg tagatttgac aaccgatttg cattccatgg gtcaatggat tcaagacggt
    22561 gagcgtacga ttttcgaaac ggttatctcc gtggaagcta cagatcatag cgtattggtt
    22621 cctacagacg aggctgattt ggatggattg aacttcttgg caggcaagca tgtagacgag
    22681 gtaaacaaga tggctgagtt aggtactcag ttagctcacg tagatggtgg cgttcctaat
    22741 atcaaggtaa ctatgccgga agtaagtgcg ttctatattg gtcagttgtt ctatttcttc
    22801 gagaaagctt gtggcatcag tggttatatg ttgggcgtta acccattcaa tcaaccgggt
    22861 gtcgaggctt ataagaagaa tatgttcgcc ctgttgaata agccgggata cgagaaagaa
    22921 agcgaagcta tcaaagcacg tttataatac gatttacccc ataaaaaaac ggttttctca
    22981 tcacgaggaa accgtttttt cgtttgaata gtttttatta ctcatttaat tctttaagta
    23041 aatcgctccc ggccttgaat ttgaccgaga cacgtggagt aatcattact tcctcccctg
    23101 ttttcggatt acgtgccaat cgctcggatt gttgccaagg tacaaaagat ccaaatcctt
    23161 tcatggaaat agattctcct tcccgtattc ctttcgccac aacagtcggt aacgcattca
    23221 ctacggttct aacaacattt ttcggcaatc ctgtttcttc cacaagagat tgtactaatt
    23281 ctcctctatt catactagat aataaatata ccattcttca ccagaaaaga gtccggtgag
    23341 aacttagttg tttaatcatt gcaaatatat gaatatttgg ggaatatcaa aataacatat
    23401 attaaaaatc aatgcataca gaaatattat atacctaaat gtaggtataa ttgaacccct
    23461 ttcagataga caagtgagac tttggtagaa atataattaa taagaaatag tatacagtat
    23521 tatgatatca cttattcata gcaagttata gcctttgaaa attcgttatt aatgcgttta
    23581 ctagagttct caccgaacta cgtcataatt tattgattaa ttatctcaac gaaataaatt
    23641 tatatccctt atttttcaat acatctatca actcatccag ataattatag aatttatcaa
    23701 tccggttagg gtgtacatgt aggtggatca aaagtaagca cccatttaaa ccatttttgt
    23761 ttcataaaat gaaatttcat tatatatcat atttatttaa tttcaagaag ctttcctccc
    23821 atttctgtta attccgattt attacgtacc tttgtattgg tttttaagaa ggttataaca
    23881 tgattcaaga agcgattatc cgatatctgc gtaaacacag gcaggaatcc ctttctccca
    23941 aagctgttct tttcgatatg gatggtgtat tatatgactc tatgcgtttt catgcacggg
    24001 catggcatga ggtagcgacc ctccatcagc taacttctcg gccggaagac ttttatatgt
    24061 tcgaaggacg tactggggaa agcacgatca acgagctata ccaacgcact ttccaacgag
    24121 acgctaccgc cgaggagaag caaacgatct ataaagagaa agcggatcta ttcaatacct
    24181 ataatgacgg tgcccccatg accggcgccg cagaggttct aaaagaagtg gaagcatccg
    24241 gactgcaacg attggttgtc accggttccg gccaacatag cttgatcgat aagctaaacc
    24301 atacctatcc gggacatttc aaccgagaga aaatggttac ggctttcgac gtgaaatatg
    24361 gcaagccaca ccccgaacct tatttaatgg gacttcaaaa agcgcatgcg aagcctaatg
    24421 aaacttttgt ggtagagaac gctcccatgg gagtagaagc tgccgtggca gccaatatct
    24481 ttacgatagc cgtaaacacc ggacctctcc ccgatcaagt tttattagat gccgga
//
