LOCUS       c00043_gnlPro..        12229 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NMLEJDGF_43.
ACCESSION   c00043_gnlPro..
VERSION     c00043_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 08:04:46
            Original ID  :: gnl|Prokka|NMLEJDGF_43
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12229
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1161
                     /locus_tag="ctg43_1"
                     /transl_table=11
                     /translation="IGKNKVRQPLAANFSVPIALFWKLSDADGTELLGAFRPKKAINTM
                     GLYFSEPYDPRKIPVVFTHGLMSGPATFANLTNRLLVDPVIRENYQFWFFGYPSGLAWT
                     IPASRQRQALKELMQEYNPRGTSREMNNIVMVGHSMGGLITRFNNSTKPWTLMKGVFEL
                     SPETFEGMTLENWKKGMAPLHYDEQTLERLQNNFIFSPPQGVTRIVYMATPHRGSTFAD
                     NWIGRLGQRLIDLPSDMLEEVTRIATLSRGMFLLNPLQLKDELTSIRQLSPNSSLVKYM
                     SELRGSPNVPVHSIIGDRGRNDTPNSSDGVVKYHSSHLDWSASEKIVPSGHSVQDDPAS
                     AVELRRILREHLVKVKGRKTLEEADAKAATPVWQANPSPPIILKRL"
     protocluster    1..12229
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[5863:12227]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      5864..12227
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12229
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12229
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(1376..1516)
                     /locus_tag="ctg43_2"
                     /transl_table=11
                     /translation="MPGWSEPFSVTGQSNQGSQEQAVMSGENFSCFNRRGGMLPQMPAA
                     R"
     CDS             1636..3276
                     /locus_tag="ctg43_3"
                     /transl_table=11
                     /translation="MSADDSFPMDQISSLFPQLENIQLVGAKGPQQIFTATLKSNFAPV
                     MLRVVPTEEAGIFGWDPEFIVRSLTIVEQSHQGLLRVYEVGQAEPFTFIISEHPPYPRM
                     ADMETLPQISPQAALNLVRNMAEGLLTLHRKNIFHGGITPKLICLREDGGDALLLPINI
                     YPAQPPVDMGDFASPEWVTGAETTFTPGMDIYALGLALYILLTRKTPMEAGFAMPSSLI
                     KCSDAVDSAVSRAINPDTRERYRDLGDFITDLDKAIANPSGRNAASIPPPSSSPAIPTL
                     NMQKGQSNIYYYLIPALIVGIVLTYTCILYKKDVVRMRNDYNEQVQKENNAKAEAARQA
                     NRDARRHAPATAQNAAAVIPSPVPAARPAQAPAVPKVSAEPGKINWSLQPGVKVRQSSN
                     RNMLGAYGPEKAVDGNTSSRISDVSISATGVVEGKTAWFGIDFGRETNRTIEKVVIYTP
                     ANLTLLGTMEKFKVILYGNDKNVLAEKTFSTTPSEKSTNVTSWKLDAPVKARALRVESA
                     NPSQPLALTEVEAYGPEDAEDTPVPAPAE"
     CDS             3380..3586
                     /locus_tag="ctg43_4"
                     /transl_table=11
                     /translation="MECHALSSGFGFAYEIFRFLLHSPEAIQARTEENPKNVFAPDRKQ
                     PPLSTFPTPEKRSHPHMAPGEIS"
     CDS             complement(3702..4049)
                     /locus_tag="ctg43_5"
                     /transl_table=11
                     /translation="MNIINKIEQEQLKADVTPFNVGDTIKVHTRVIEGGKERIQIFQGI
                     VIAKRGSGINEAFTVRKISYGEGVERVFPLHTPRIAKIEVVNRGKVRRAKLHYLRGRIG
                     KDAMIVKSANR"
     CDS             complement(4159..5697)
                     /locus_tag="ctg43_6"
                     /transl_table=11
                     /translation="MFKSGLAVLFLLASWFSAACAYELLPAHVAVVYNGKSELSRRMAR
                     EYARVRGVPEGNLVSLDCPMTGEISRKEYEETIRVPLLETARKQRWWTPSGIASSPLMN
                     RKIFVLALMADLPMKIRHETPAPLPGKGVNQMQTDRAAVDSELALLAVGGYERKSWQVN
                     PYFNKREDFVGSGLPSFLVCRLDGLTPDTCMRLVTEPANVEKKGLWGWAVVDRGGPYAQ
                     GDRWMDDVFERVREAGIPAYLDDWPQTLPEKFPLSRDTALYCGWYAGNANGPFSDPSFR
                     FRPGAIAMHLHSFSAADFKVPGRGWSSALLEKGAAVTVGNVYEPFLGACHRFDIFVDRL
                     LDGYTVAEASWMSMPVLSWQGVVFGDPLYRPYARMKDMDVEPTEEDRYFQGWWASSVQF
                     GDRWKERSARLMESARKAPFSCLYEALALECLYRKEPARAGELLSSALDGAADARTRAR
                     LLLEILMAERARGGNKAFLQRADGIRGLMSSSAFLPALEEWLARVAPPPAPPKK"
     CDS             5864..6286
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_7"
                     /sec_met_domain="Glyoxalase_4 (E-value: 6.6e-26, bitscore:
                     80.6, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIQQIDHIGIAVKSLDATVPYYRDALGLGEPHIEEVPTQKVRVAM
                     FDVAGVHIELLEPTSPESAIAKAIEKKGEGIHHIAFKTNDIAGNISQAKEAGLTVLNDP
                     PVPGAHNTQVTFLHPKCTFGVLTEFCQHPGGCECGK"
     CDS             6318..7883
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Vparvula"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_8"
                     /sec_met_domain="CT_Vparvula (E-value: 1.2e-216, bitscore:
                     709.8, seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAIDPKLIDDLNSRRKKVILSGGQEKIDKRHEKGEMTARDRMGYL
                     FEEGTFSEIGMHVRHNCHNFGMGKKEIPGDGVVSGFGLVDGRPVACAASDFLAQGGSLG
                     YMHAMKIADAQKYALKAGIPMVTVNDSGGARLQEGVAALSGYAQVFYNNVLASGVVPQI
                     SMILGPCAGGAAYSPALTDFIIMRNSGNAGMYITGPKVIEQVTYEKCTMDDIGSAAIHA
                     TVSGNVHFVADSDAHAMDILKRLLSFLPSNNTEEPPHKLDTPLDLSADEGMSDLIPGDN
                     RTPLDVQPIISRLVDNGDFLEVHKDFAKNVVVGFGRICGVVVGIIANQPNVKAGCLDID
                     SSDKAARFIRFCNAFNIPLVNLVDVPGFLPGKNQERGGIIRHGAKLIFAYSQATVPKVT
                     LIMRKAYGGAYIAMCCKDLGADAVFAWPGAEIAVMGAEGAVPVLYGRELKAVEDPAEKA
                     KRQGELLEEYREAFYNPYVAAGMGQITEVINPEETRAKIAFALRTLLNKKEVRPAKKHG
                     NIPL"
     CDS             7904..8350
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_9"
                     /sec_met_domain="OAD_gamma (E-value: 2.8e-11, bitscore:
                     33.8, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLLTTLAFAQGIANVMNNLNYQIVGIMVVMMCLGGLAVILTISGS
                     IAAAIQNRAKAKTAAPVAAPAAAPAAAGKPGMTPEMLAILSAAVDSAMTELTPEMVAVI
                     SAAVDAGLDGMSHRIVEIKQSPGSGYAAAGRAEIFASHRIRPSR"
     CDS             8425..8826
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 59.8; E-value:
                     5.7e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_10"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.2e-19, bitscore:
                     59.8, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKLRITVDGKVFDVSVELLDQVSSTTAAPAPAPVAAPAPAASAP
                     VAAPAPAPAPAPAPAAAGAGDVPSPLAGKVVSLDVAAGASVKAGDQILTLEAMKMNTII
                     YAPASGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             8944..10569
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_11"
                     /sec_met_domain="OAD_beta (E-value: 8.6e-160, bitscore:
                     521.1, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGIFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTSTSLNNVGYLRVHVAPLQQTPAKVPANLTTPEAR
                     AQYLETMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRVPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFNPNEAASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQAETLLIILLGIVAF
                     GVATAGGVIAAKLMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             10607..11386
                     /locus_tag="ctg43_12"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARSLPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPADTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRDCPSLHAVMASLGSHLNQVLSVFSHGGVPSLQEGLSRAWAGERPVSILTDDET
                     VRGIFTGIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             11448..12227
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: AcetylCoA_hydro"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg43_13"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 5e-45, bitscore:
                     143.7, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQKVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNAAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVG"
ORIGIN
        1 attggcaaaa ataaggtgcg gcagcctctg gcggccaatt tttccgtccc catcgctctc
       61 ttctggaagc tttccgacgc agacggaacg gaactgctgg gggcattccg ccccaaaaag
      121 gccatcaata cgatggggct ttatttttcc gaaccctatg acccccggaa aatacccgtg
      181 gttttcaccc acggcctgat gtccggcccc gccaccttcg ctaacctgac caaccgtctc
      241 ctggtggatc cggtcatccg ggaaaactac caattctggt tcttcggcta tccgtccggg
      301 ctggcctgga ccattccggc cagcaggcag cggcaggccc tgaaggagct catgcaggaa
      361 tacaatcccc gcggaacatc cagggaaatg aacaacatcg tcatggtggg acactccatg
      421 ggcggcctca tcacccgctt caataactcc accaaaccct ggacgctgat gaagggagta
      481 tttgagcttt ctccggaaac gtttgaggga atgacgctgg aaaactggaa gaaaggaatg
      541 gcccccctcc attatgatga acaaacgctt gaacggctcc agaataattt catcttttcc
      601 ccgccccagg gagtcacgcg catcgtgtac atggccaccc cgcaccgcgg ttccactttc
      661 gcggacaact ggataggaag actgggccag cgcctgatcg acctcccctc ggacatgctg
      721 gaagaagtca cccgcatcgc cactctcagc cgcggcatgt tcctactcaa ccccctgcaa
      781 ctgaaggacg agctgaccag catccgccag ctttccccga attcatccct ggtcaaatac
      841 atgtcggagc tgcgcggctc cccaaatgtt cccgttcatt ccatcattgg agacaggggc
      901 aggaacgaca ctcccaattc ctccgacgga gtggtcaagt accactcatc ccacctggac
      961 tggagcgcca gtgaaaaaat cgttccgtcc gggcacagcg tgcaggatga cccggcctcc
     1021 gccgtggaac tgcggcgcat cctccgggaa cacctggtca aggtcaaagg ccgtaaaacg
     1081 ctcgaagaag cggacgcgaa agccgccact cccgtatggc aggccaatcc ctcgccgcct
     1141 atcatcctga aaaggctctg atgcagggga ctgattctcc ttgtccatgc aaggcctcct
     1201 tcccttcccc ccttctgctg ttcctgctga taacagcagc catcttccag tcaaacggtc
     1261 acgcctcggc gatcctgttt ccgggttcct gtatgtcccg gctttaacgg ttggaacgcc
     1321 ctcgttcatc caccctccct gccgctcccg gaaaaaaaca ggaaccgaac aggatttacc
     1381 ttgccgcggg catctgcggc aacatgccgc cgcggcggtt gaaacaactg aaattttccc
     1441 cgctcattac ggcctgttcc tggctgccct gatttgactg gccggttacg gaaaaaggct
     1501 cgctccatcc gggcatgatt ggcgtccgtt cagcatcagg gcgtcccgcc atcaaaatat
     1561 gcccgcttat agagttgctt ccgtagggga atttaaggta gagtgggaat caatactatt
     1621 ccacctccct tttccatgtc tgccgacgat tcctttccca tggaccagat ttcctctctc
     1681 tttccccaat tggaaaatat tcagcttgtc ggagccaaag gcccccagca aattttcaca
     1741 gctaccctga aatccaactt tgctcccgtc atgctgcggg tggttcccac ggaagaagcc
     1801 ggcatcttcg gctgggatcc tgaattcatc gtccgctccc tcaccatcgt ggaacaatcc
     1861 caccaggggc tcctgcgcgt ttatgaagta ggacaggcgg agccgtttac tttcatcatc
     1921 tccgaacacc ccccctatcc gcggatggcg gatatggaaa cccttcccca aatatctccc
     1981 caggcggcgc tcaacctggt gcgcaacatg gcggaaggac tgctgacgct gcaccggaaa
     2041 aacatttttc acgggggcat cacgcccaag ctgatttgcc tgcgcgaaga cggcggagac
     2101 gccctgctgc tgcccatcaa tatttatcct gcccaacctc cggtggacat gggggacttc
     2161 gcctctccgg agtgggtcac cggagcggaa accacgttca cgccgggcat ggatatttac
     2221 gcactggggc tggcgctcta cattctgctt acccgcaaaa cgccgatgga agcgggcttc
     2281 gccatgccct cctcactaat caaatgcagc gatgccgtgg attcggcagt ctcccgcgcc
     2341 atcaatccgg atacccggga acgctaccgg gacctggggg atttcatcac ggatctggat
     2401 aaagccattg ccaatccttc gggaagaaat gcggcctcca tccctccacc gtcatcttcc
     2461 ccggccattc cgaccctgaa catgcaaaaa gggcagtcca acatctatta ctatctcatt
     2521 ccggccctga tcgtgggcat tgtgctgacc tatacctgca tcctgtataa gaaggatgtc
     2581 gttagaatgc gcaatgacta taatgaacag gtgcagaagg aaaataacgc gaaagcggaa
     2641 gcggcaagac aagcgaacag ggacgcgcgc cgccacgctc cggccaccgc gcaaaacgcc
     2701 gctgcggtca ttccttcacc tgttccggcc gcgcgtccgg cgcaggcgcc ggcagttccc
     2761 aaagtttccg cggaacccgg caaaatcaat tggagccttc agcccggcgt caaggttcgc
     2821 cagagttcca atcgcaacat gctgggagct tacggtccgg aaaaggccgt tgacggcaat
     2881 accagctcca ggatttccga cgtttcaatc agcgccacag gcgtggttga agggaaaacc
     2941 gcctggttcg gcattgactt cggcagggag accaaccgca ccatagaaaa ggtagtcatt
     3001 tacacgccgg ccaacctgac gctgctgggc actatggaaa aattcaaggt aatcctctac
     3061 ggcaatgaca aaaacgtgct ggcggaaaaa accttcagca ccactccttc ggaaaaatcc
     3121 accaacgtca cttcctggaa actggacgct ccagtcaagg cgcgcgcctt gcgcgtggaa
     3181 tccgcaaatc cctcccagcc cctggcgttg acggaagtgg aagcgtacgg accggaagat
     3241 gcggaggaca caccggttcc cgcacctgcg gagtaataat tatccgcgca gccctgcacc
     3301 cgctcgcccc ccctccgggg gccatgctga aaccccgttt cctttccccc tcccggaaat
     3361 caggttgggg cagggcctga tggaatgtca cgcgctaagt tccgggtttg gattcgcgta
     3421 tgaaattttc cggtttctgc tccattctcc ggaagccatc caggcccgga cggaggaaaa
     3481 tccgaaaaac gtatttgctc cggaccggaa acagccgccc ctctccacct tccccacccc
     3541 ggaaaaacgc tctcatcccc atatggctcc cggagaaata tcttgaagtg gctgttgttc
     3601 ctgtggacct ctttcccatt caggaaaaac aatactccgg aaataaaaaa cccggcgccg
     3661 cctcacggcg ggccgggcca gcaaaatagc aattcttccg attaccggtt ggcagacttc
     3721 acaatcatgg catccttgcc gatgcggccg cgcagatagt gaagtttggc gcggcggact
     3781 ttgccgcggt tcacgacttc aatcttggca atgcggggag tatgcagggg gaatacgcgt
     3841 tccacgcctt caccgtagga aattttgcgg acggtgaaag cttcattgat gccggaaccg
     3901 cgcttggcga tcacaatgcc ctggaaaatc tggatacgtt ccttgccgcc ttcaataaca
     3961 cgagtgtgaa ccttgatggt atcacctacg ttaaatgggg tcacatccgc cttgagttgc
     4021 tcttgctcga ttttgttgat aatgttcatc ttgtgttatc tattgctggt gaatatcagt
     4081 aaaaggaaaa cttacgggac gcagaatatg agccataatc ccctaaaagg caatccaaat
     4141 ttgccgtacg tccttaattt attttttcgg cggggccggc ggcggagcca ccctggcaag
     4201 ccattcctcc agcgccggaa gaaaagcgga ggaagacatg aggccccgga tgccgtccgc
     4261 acgctgcaga aaggccttgt taccgccccg ggcccgttcc gccatcagga tttccagcag
     4321 cagacgcgcg cgggtgcggg cgtctgccgc gccgtccaga gcggaggaaa ggagctctcc
     4381 ggcgcgggcc ggttccttcc ggtacaggca ttccagcgcc agagcttcat aaaggcagga
     4441 aaaaggggcc ttccgggcgg actccatcaa acgcgcggaa cgctccttcc agcggtctcc
     4501 gaactgcacg gaggaagccc accacccctg gaaataacgg tcttcttccg tcggctccac
     4561 gtccatatcc ttcatgcggg cgtatggacg gtacaggggg tctccgaaca ccaccccctg
     4621 ccaggacagc acaggcatgc tcatccagga agcctccgcc acggtatagc catccaggag
     4681 gcggtccaca aaaatatcaa agcggtggca ggcgcccagg aacggctcat acacgtttcc
     4741 caccgtcaca gcagccccct tctccagcag ggcggaactc caccccctgc cggggacctt
     4801 gaaatcggcg gcgctgaagg aatgcagatg catggctatc gccccgggcc ggaagcggaa
     4861 cgaaggatcc gaaaacggtc cgttcgcatt ccccgcatac cacccgcagt aaagagccgt
     4921 atcccggctc aaggggaatt tttccggcag ggtctggggc cagtcatcca gataagcggg
     4981 aatgcccgcc tccctcacgc gctcgaacac gtcgtccatc caccggtccc cctgggcata
     5041 ggggccgccc cggtccacaa cggcccaccc ccataaacct tttttctcca cgttcgccgg
     5101 ttccgtcacc agccgcatgc aggtatcggg cgtcagtccg tccaggcggc ataccagaaa
     5161 cgaaggaagg ccggaaccca caaaatcctc ccttttatta aaatagggat tcacctgcca
     5221 ggacttcctt tcataaccgc ccaccgccag cagagccagt tcggaatcca ccgcagcgcg
     5281 atccgtctgc atctggttga cgcctttccc gggaagggga gcgggcgttt catgccgtat
     5341 cttcatcggc aggtccgcca tcagcgccag cacaaaaatc ttccggttca tcaaggggga
     5401 ggacgcaatg ccggaaggcg tccaccaccg ttgtttccgc gccgtctcca gcagcgggac
     5461 gcggatcgtc tcctcatact ccttccgcga aatctcgccg gtcatggggc aatccaggga
     5521 aacgagattc ccttccggaa cgccgcgcac ccgcgcatat tccctggcca tgcggcggct
     5581 cagctcggat tttccgttat aaaccacggc cacatgagcg ggcagcagct cataggcaca
     5641 cgcggcggaa aaccatgacg ccagcagaaa taacacggct aatccactct tgaacatgcc
     5701 cctaccatac ctcatcttcc ggggcaatca agcaggtgaa aaggccggcc acgaattcgc
     5761 catttttccg cttttcgctt cacatcttaa aaaaatccgc tttaataact cttgatgtat
     5821 tgcaggcctc ccccctgcat tcccctataa ccatcacacg catatgattc agcaaattga
     5881 ccatatcggc atcgccgtca agagtcttga cgccaccgtt ccctattacc gcgatgcgct
     5941 cgggctcggc gagccccaca ttgaggaagt ccccactcaa aaggtccgcg tcgccatgtt
     6001 tgacgttgcc ggcgtccaca tcgaactgct cgaacccacc tctccggaaa gcgctatcgc
     6061 caaggctatt gagaaaaaag gggaaggcat ccaccacatc gctttcaaga ccaatgacat
     6121 cgccggaaat atctcccagg ccaaggaagc gggccttacc gtgctgaacg acccgcccgt
     6181 ccccggcgcc cacaacacgc aggtcacctt cctgcatccc aaatgcacct tcggcgtcct
     6241 gaccgaattc tgccagcacc ccggcggctg cgaatgcggc aagtaacatt ctccctattc
     6301 accataccac tataccaatg gctattgatc ccaaattgat tgacgatctg aacagccgcc
     6361 gcaagaaggt aatcctcagc ggcggtcagg aaaagatcga caagagacat gaaaagggcg
     6421 aaatgacagc ccgcgaccgc atggggtacc tctttgagga aggcaccttc tcggaaatcg
     6481 gcatgcatgt gcgccacaac tgccacaact tcggcatggg caagaaggaa atccccggcg
     6541 acggcgtcgt ttccggcttc ggcctggtgg acggccgtcc ggtggcctgc gcggcctccg
     6601 acttcctggc ccagggcggg tccctcggct acatgcacgc catgaaaatt gcggatgccc
     6661 agaagtacgc cctgaaagcc ggcatcccga tggtgaccgt gaacgactcc ggcggcgcgc
     6721 gcctccagga aggcgtggcg gccctttccg gctatgccca ggtgttctac aacaatgtgc
     6781 ttgcctccgg cgtggttccg caaatctcca tgattctggg tccctgcgcg ggcggcgcgg
     6841 cctactcccc cgccctgacg gacttcatca tcatgcgcaa ttccggcaac gccggcatgt
     6901 acatcaccgg ccccaaggtg attgaacagg tcacgtatga aaaatgcacg atggacgaca
     6961 tcggctccgc cgccattcac gccaccgtgt ccggcaacgt ccatttcgta gcggacagcg
     7021 acgcgcacgc catggacatc ctgaagaggc tgctttcctt ccttccttcc aacaacacgg
     7081 aagaaccgcc ccacaaactg gataccccgc ttgacctgag cgcagacgaa ggcatgagcg
     7141 acctgattcc cggcgacaac cgcacgccgc tggacgtcca gcccatcatc agccgcctgg
     7201 tggacaacgg ggacttcctg gaagtgcata aggacttcgc caaaaatgtc gtcgtcggct
     7261 tcggccgcat ctgcggcgta gtagtcggca tcatcgccaa ccagcccaac gtgaaagccg
     7321 gctgcctgga tatcgactcc tccgacaagg ccgcgcgctt catccgcttc tgcaacgcgt
     7381 tcaatattcc gttggtgaac ctggtggacg tgcccggctt cctgcccggc aagaatcagg
     7441 aacggggcgg cattatccgc cacggcgcca aactcatctt cgcctattcc caggccacgg
     7501 tgcccaaagt caccctgatc atgcggaaag cctacggcgg cgcctacatc gccatgtgct
     7561 gcaaggacct gggcgctgac gccgtcttcg cctggcccgg cgcggaaatc gccgtcatgg
     7621 gcgcggaagg cgccgttccg gtgctctacg gccgtgaatt gaaggctgtg gaagacccgg
     7681 cggaaaaagc caaacgccag ggagaactcc ttgaagaata ccgggaagcc ttctacaacc
     7741 cgtatgtggc ggccggcatg gggcagatca cggaagtcat caatccggaa gaaacccgcg
     7801 ccaaaatcgc cttcgccctg cgcaccctgc tgaacaagaa ggaagtgcgc ccggccaaga
     7861 aacacggcaa cattccgctc taacatccat ctcaacggat catatgttac tcacaacact
     7921 cgcctttgca cagggcatcg ccaacgtcat gaacaatctg aactatcaga ttgtcggcat
     7981 tatggtggtc atgatgtgcc tgggtggcct ggccgtcatt ctgaccatca gcggctccat
     8041 cgccgccgcc attcagaaca gggctaaagc caaaaccgcc gctcccgtgg ccgcgcctgc
     8101 cgccgccccc gctgcggcgg gcaaaccggg catgacgccg gaaatgctcg ccatcctctc
     8161 cgcagcggtg gactccgcca tgacggagct cacgccggaa atggtggccg tcatctccgc
     8221 cgccgtggac gcgggcctgg acggcatgag ccaccgcatt gtggaaatca agcaatcccc
     8281 gggctccggc tatgcggccg caggcagggc ggaaatcttc gcctcccacc gcattcggcc
     8341 ttcccgttga actacagcat tattcaccct tacccccgcc ccggcgggaa ccatttaact
     8401 taatactcca taccatacat tatcatgaag aaacttcgca tcaccgtaga cggcaaggta
     8461 tttgacgtat ccgtagaact cctggaccag gtatcctcca ctaccgcagc cccggccccc
     8521 gcacctgtgg ccgctcccgc tcctgccgca tccgcacccg tggccgcccc ggctccggct
     8581 cccgcacctg cgcccgctcc ggccgccgcc ggcgccggag acgtgcccag cccgcttgcc
     8641 ggcaaggttg tttccctgga cgtggccgct ggcgcctccg tgaaggccgg cgaccagatt
     8701 ctgacgctgg aagccatgaa gatgaatacc atcatctacg ctcccgcctc cggcacgctc
     8761 accgctttct gcgtaaaccc gggtgatacg gttcaggaag gacaggctct ggccaaaatt
     8821 ggttaatccc ggcggcaacc gcccggaacc tccaacagtt cctggctccg actcagataa
     8881 caaaccgcta caataacatt ccgtatgagt ctttttgatt cattaatcac ctttttacag
     8941 gggatgggca tcttctccct atcatggcaa atggtaggga tgtggggcat tgccatcctg
     9001 ctcctgtatc tgggtgtagc caagcaatac gaacctctcc tgatggttcc cattgctttc
     9061 ggcgccctca tcgccaacat tccggacaac ggaatgctca tcacccagct gaaccagcag
     9121 gtcatctcct ccaatgaaca gggggaagta acctccacgt ccctgaacaa cgtgggctac
     9181 ctgcgcgttc atgtggctcc tctgcagcag acgcccgcca aggtgccggc caatctgacc
     9241 acgccggaag cccgcgccca gtatctggaa accatgcagc agcccatgca ggtttatccc
     9301 ggcagccagc tgaccgtttc caaaatcaag tccgtgcggg aatcccagga aaaagccaaa
     9361 gctgacgccg cccgcctggg agacgacagt ctgacggtgg atcccaacct gaaggacttc
     9421 cagaacgtga cggaggacaa cggcaatgag ccggtcttcc tgctcacgaa cggagaagga
     9481 accaccgtcg tccgccagca gggcgtcaat tactttgaca ccagcggcaa ccgtgttccc
     9541 gtggacctga aaacgcagaa gctggaaccc ctggtggttt ccgccgcagg caaatacgtg
     9601 gccgtaggcc aacataccca ggaactgctg gtcacctcca tccacggggg cctgtatgac
     9661 tggatcgggc tgggcatcaa ggctgaaatt ttcccgccca tcatcttcct gggcgtagga
     9721 gccctgacgg acttcggccc gctgctcgcc gcaccgcgca ccctgcttct gggcgcggcg
     9781 gcccaggtgg gcgtagccgc cacgttcttc atggccctgt tcatgggctt caacccgaat
     9841 gaagccgcct ccatcggcat catcggcgga gctgacggcc ccacttccat cttcctgacg
     9901 atgaagctgg ctccgcacct gctgggcgcc gtggccgtgg ccgcatacac gtacatgtcc
     9961 ctggttccgc tgatacagcc gcccatcatg gcgttgctga cgaccaagaa ggagcgcctc
    10021 atccgcatga aatccctgcg gacggtcagc aagagcgaaa aactgttctt cgccgtgctg
    10081 gtaaccattg tcaccattct gctgattccg gacgcatccc cgctcatcgg catgctgatg
    10141 ctcggcaact tcctgcgcga atgcaaggtg acggaacgcc tggttcaggc ctcccagaat
    10201 gaaatcatca acatcgtcac catcttcctg ggaacctccg tgggtctcac gatgcaggga
    10261 gaccgcttcc tgcaggcgga aacgctgctg atcattctgc tgggcattgt cgccttcggc
    10321 gtagccactg cgggcggcgt catcgccgcc aagctcatga acctcatctg gcgcaagaat
    10381 ccggtcaacc ccctcatcgg gtccgcaggc gtctccgccg tcccgatggc agcccgcgtc
    10441 tcccacaatg tgggccagaa gtacgacccc tccaactatc tgctcatgca cgccatgggc
    10501 ccgaacgttg caggcgtgat cggcaccgca gtcatcgcgg gctactacat cgccactctg
    10561 gcgaaataac cagaattgaa aattactccc ggcctcggcc cgtcccatga attccgcagc
    10621 ctcattttcc acccctccgg aggaggaagg accatgcggc gactggactt atcatgaatg
    10681 ggccgaggct ttttccacca atgacctggc ccgctccctg cccccggggc atattgccgt
    10741 ctgccgcgtt cagacaggag gccgcggcag gttcaaccgc aaatggatag gggaggaagg
    10801 cggcctgtgg gcatccttca ccgttcccct gtccgctcct gcggatacag cggccggcgt
    10861 gcactggggc catttgcccc tggttgcggg gctggccctg ttcaacatgc tccgcggcat
    10921 ggggctggat tccgtgcgcc tgcgctggcc gaacgacctg ctggcgggca aatccaaact
    10981 ggcgggaata ctggtggaac gcccggcgga gaacatggcc gtcatcggca tcggcatcaa
    11041 tgttttcaat gatgtatcct ccatcgccgg ggaaatcaag gaccctccgg caaggctggc
    11101 ggatcttgtt cgggactgcc cttccctgca cgccgtcatg gcttctctgg gcagtcattt
    11161 gaaccaggtt ctttccgtct tttcccacgg cggcgtcccc tcccttcagg aggggctgtc
    11221 ccgggcatgg gccggagaaa ggccggtttc cattcttacg gatgacgaaa ccgtccgggg
    11281 catttttaca gggattgacg atcagggcaa tcctgtgcta tcccttccgg ccggcaccgt
    11341 ccgcaccatt ccggcgcacc tgatcaacag gctcctcgaa gaatgagcct accgctccgt
    11401 ttttacacgg ggtttctttc ttttttcatc caacaaaaat cactgacatg agttacaagg
    11461 tactgacacc agaagaagca gcaagcctga tcaagcatgg ccaccatatt gggctgagcg
    11521 gattcacgcc cgccggaacg gccaaggccg ttacggctgc gctggcaaaa atcgcagaag
    11581 cggaacatga gaaggggaac cctttccagg tgagcgtctt caccggcgct tccaccggcg
    11641 attcctgcga cgggatcctt tcccgggcca aggcaatccg ctaccgcgct ccctacacca
    11701 ccaacgttga tttccgcaag gcggtgaaca acggggaaat cgcctataat gacatccatt
    11761 tgtcccagat ggcccagaaa gtgcgctacg ggttcatggg caacgtggac atcgccatta
    11821 ttgaagcctg tgaagtcacg gccgacggca aaatttacct gacggccgcg ggcgggatcg
    11881 ctcccaccat ctgccgcctg gcagacaaaa ttatcgtgga attaaacgcc gcccacagca
    11941 agagcgccat gggcctgcac gacgtttacg aacccctgga tcctccctac cgccgcgaaa
    12001 tttccatctt caaacctagc gaccgcatcg gcaagccgta catccaggtt gacccgaaaa
    12061 agattgtggg cgttgtggaa accaactggc cggatgaagc ccgttccttc gccgcagcgg
    12121 atcccctgac cgataaaatc gggcagaacg tggccgattt cctggctgcc gacatgaaac
    12181 ggggcatcat tccctccacg ttcctgcctc tccagtccgg cgtgggcaa
//
