LOCUS       c00062_gnlPro..        11879 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LGOFKNNH_62.
ACCESSION   c00062_gnlPro..
VERSION     c00062_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 05:55:23
            Original ID  :: gnl|Prokka|LGOFKNNH_62
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11879
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..246
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg62_1"
                     /sec_met_domain="SDH_alpha (E-value: 1.6e-22, bitscore:
                     69.9, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVE
                     GIIDEDVDQSIRNLTKIGSKGMNETDKLVLEIMTSK"
     protocluster    1..11879
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1444:7404]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1445..7404
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11879
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11879
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(383..955)
                     /locus_tag="ctg62_2"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     GGGCGSCGCGDCGDGCGDHECGGGCCH"
     CDS             1445..2704
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_3"
                     /sec_met_domain="ILVD_EDD (E-value: 1.2e-129, bitscore:
                     422.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKKLFEDAARLIVENAFRYYEEGDESVLPRSIATRKAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXQGWRSGGFEGKYSSGRLRCQDCRCR
                     REYLEIYGASESLRLTRCGL"
     CDS             2781..3125
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_4"
                     /sec_met_domain="ILVD_EDD (E-value: 1.9e-45, bitscore:
                     144.9, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHVSPEAA
                     AGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNREVSKALKAYASMVSS
                     ADKGAVRLID"
     CDS             3217..4968
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.3e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAERPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             5001..5561
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_6"
                     /sec_met_domain="ALS_ss_C (E-value: 6.7e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             5558..6310
                     /locus_tag="ctg62_7"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             6361..7404
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg62_8"
                     /sec_met_domain="IlvN (E-value: 4.3e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.8e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIVMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(7466..9379)
                     /locus_tag="ctg62_9"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQLLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQI
                     NAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGD
                     HCQLPPTIKCHEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGE
                     LEAASEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINR
                     ISGNRILEEKIDFGIISPYKAQVQYLRNKIKADASLKPYRSLFTVNTVDGFQGQERDVI
                     FISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIG
                     NQ"
     CDS             9494..11737
                     /locus_tag="ctg62_10"
                     /transl_table=11
                     /translation="MVYDLTMLKAFYAAYSEKIERVRNVLQRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLENYAFPGGMMVGTDSHT
                     PNAGGLGMVAIGVGGADAVDVMTGMEWELKMPRLIGVHLKGKLSGWVAPKDVILKLAGI
                     LTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEVGATTSLFPYDERMGTYLKATGRE
                     EVAKMAASVAADLRADDEVLANPEKYYDRIIEIDLSLLEPYINGPFTPDAATPISKFAE
                     VVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQVKEKNLKVASSLIVNPGSEQIRA
                     TAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDDPERKNSIVTSFNRNFAKRADGNP
                     NTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGEVVKLSEPVGEELPAHGFIGGKEG
                     YIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLNMPLLIKVQGKCTTDHISMAGPWL
                     RFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTYGTVSGTAKLYKSEGIPSIVVAEE
                     NYGEGSSREHAAMEPRFLNVRAILAKSFARIHETNLKKQGMLALTFTDKADYDKIRERD
                     LISVMGLKDFASGRTLKVVLHHEDGSKESFEVQHTYNEQQIAWFRAGSALNAR"
     CDS             11741..11878
                     /locus_tag="ctg62_11"
                     /transl_table=11
                     /translation="MEKITVPFITGDGVGAEVTPSMQAVVNAAVKKSYGDRRGIEWKEV
                     L"
ORIGIN
        1 atgattgcca atcttaccgg aatgatttgt gatggtgcca aacccagttg tgcattgaaa
       61 gtaactaccg gagtttcaac cgcagtgctt tcagccatca tggccatgga aaaccgttgt
      121 gtgacttccg tagaaggtat tattgatgag gatgtggatc agagtatccg taatctgaca
      181 aaaatcggtt ctaaaggaat gaatgaaacg gataaattgg tattggagat aatgacaagt
      241 aaataatata gaatttgaaa attaaagaat taaaaattaa agaattaaaa attaaagaat
      301 taccatgcgg catgcttaat actgtgtagt ctgattcttt aatttttaat tctttaattt
      361 ttaattctta attcttaatt ctttagtggc agcatccacc tccacattca tggtcgccgc
      421 atccgtcgcc acagtcacca caaccgcagc tgccgcaacc gccacccatc atacgggcaa
      481 cttcagcaag ctcttcgttc gtagccgggc ggctttccac cacttctccg gtaaagttca
      541 aatcacaacc tgcgagtgga tgattcatgt ccattacaac tacgtcttcc tttacttcta
      601 ctacacttcc attgatgcgt tgaccttcag aagtcatcaa ggggatgacg gcgccttcca
      661 ctacacggtc gctgtcgaat tctccttcta tcatgaagat ttctttgggg aggtcaataa
      721 catggtcgtc gtcatattca ccataagctt ctgatgccgg aatggtaaag tcgaatttat
      781 cgcctatctg caagtctttt atctgggctt caaagggttc gagtgtcatt cccagacctg
      841 agataaactg aaaaggatgc tctacgggtg cttcttcttc gaaatctttt tctccgtttt
      901 cgattgagta cagcttatat gctacggtga tgtacttgtt ttctactgtt tccattaatt
      961 ttctatcttt atttaattag taaatacttt tttttgagta tttgaagaga caaagatacg
     1021 aattatttgt ttcgggatgt agagagcctt tggtaatttt cagattatta aatggtttca
     1081 atgattggca atacatttac attggctgtc tgaatggtgc tatttagaac tgttaagtga
     1141 taaaatagga ttttagggcg atattttctt acgattattc atatttatct tatttttttc
     1201 ttcaatttgt ttggagatta taaaaaagcc cttacctttg cagcacgttt gaaacaaaaa
     1261 agaagaatta agttatgaat ttacatacat ctattaacct ggcagtcctg catattattc
     1321 gcgtcgtggt ggtggcatca agagcgtgag aaaggttatg tatgtattcg tacgttagaa
     1381 gataatttat taagcctttc tcactatagt gggagaggct ttttcattaa aaggagattt
     1441 gaaaatgaag catcagttac gcagctcgtt cagcacacaa ggtcgccgca tggcgggagc
     1501 ccgtgcattg tggacggcga atggtatgaa gaaggaacag atgggtaagc ccattatcgc
     1561 tatagtcaat tcatttacac aattcgtccc cgggcatgta catctgcacg aaataggcca
     1621 gtttgtaaag gaagagattg aaaaactggg gtgttttgct gcggagttca atacgattgc
     1681 cattgacgac ggtatcgcta tgggacacga cggtatgctt tattccctgc cttcaagaga
     1741 tatcattgcc gatagtgtgg agtatatggt aaatgcccat aaggcagatg ctatggtttg
     1801 catcagtaac tgtgacaaga ttactccggg gatgctgatg gcggctatga ggctgaatat
     1861 accgactgtg tttgtttcag gcggtccgat ggaagccggg gaatggaacg gacagcattt
     1921 ggatttgatt gatgccatga ttaaatctgc tgatgaaagt gtgggcgata aagaggtggc
     1981 acagattgag caacatgcct gccccacttg cggatgctgc tcaggcatgt ttaccgctaa
     2041 ttccatgaat tgcttgaatg aagcgattgg attggcactg cccggtaacg gcacgattgt
     2101 agccactcac gaaaatcgca agaaactatt tgaggatgca gccaggttga ttgtagagaa
     2161 tgcctttaga tattatgaag aaggggatga gagtgtactc ccgcgcagta ttgctacccg
     2221 caaggcattt ttgaatgcca tgacgctgga tattgcgatg ggcggttcca ctaatacggt
     2281 acttcatttg ttggctgtgg ctcacgaagc cggagcggat tttaagatgg acgacattga
     2341 catgctctcc cgcaagaccc cctgcttatg caaggtggct cccaataccc aaaagtatca
     2401 tgtacaagac gttaaccgtg ccggtggcat cattgccatc atggatgagc ttgccaaggg
     2461 cggannnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     2521 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnagcaag gatggcggtc
     2581 tggcggtttt gaagggaaat atagctcagg acggttgcgt tgtcaagact gccggtgtag
     2641 acgagagtat ctggaaattt acggggccag cgaaagtctt cgactcacaa gatgcggctt
     2701 gtgacggtat tctgggtgga aaggtggtca gtggagacgt cgtcgtcatc actcacgaag
     2761 ggccgaaagg tggaccgggt atgcaagaga tgctttatcc tacttcttat atcaaatccc
     2821 gccatctggg taaggagtgt gcattgatta ccgacgggcg tttcagtggt ggtacttccg
     2881 gactaagtat cggacatgtt tctcccgaag cggctgccgg tggtaatatc ggcaagatta
     2941 aggatgggga cattatcgaa attgatatac cgaaccgttc tatcaatgtg aagttgacgg
     3001 atgaagagct tgcagcacgc cctatgactc cggtaacccg caaccgtgaa gtctccaaag
     3061 cattgaaagc atatgccagt atggtgagtt ccgctgacaa aggggctgtg aggctgattg
     3121 attaaaagcc cccctttccg aaagcgaggg gaggagagaa tgaaacaaat ttttcaagct
     3181 actattgagc ttttaaatat aatgaataga taaagtatgg ctgataataa taaaaagagt
     3241 aacttttcct ccctctccca aggagagggt cggggtgagg ctctaataac aggcgcagaa
     3301 gcattgatgc gctctctgga gcatcaggga gtaaagacta ttttcggtta tccgggaggg
     3361 agcatcatgc cggtattcga tgccttatac gaccaccgga aggaattgaa ccacatcttg
     3421 gttcgccatg aacaaggagc aacccatgcg gcacaaggct ttgcacgtgt atcaggcgag
     3481 gttggcgttt gtctggttac cagtggaccg ggtgctacca atactatcac gggcattgca
     3541 gatgccatga ttgacagtac gcctatcgtt gtcattgccg gccaggtagg gacgaacttc
     3601 ttgggtacgg atgcatttca ggaagtggac ttggtaggca ttactcagcc tatcacgaaa
     3661 tggagttacc agattcgtcg tgcagaagat gtggcttggg cagtggcacg tgctttctat
     3721 gtggcaaaga gcggacgtcc gggaccggtc gtgctggatt ttgctaaaaa cgcccaagtg
     3781 gagaaaacag aatatgcgcc tactaaggtg gactatgtcc gtagctatct tcccgttccc
     3841 gaaatggagc cggaggccat acggaaggct gctgaattaa taaatggtgc ggaacggcct
     3901 ttggtgctgg taggacaagg cgtggagctg ggagaagccc agcaagagct tcgtgctttc
     3961 attgagaaag ccggaatgcc tgccggatgc actttattgg gactttccgc attacctacg
     4021 aaccatccgt tgaacaaagg aatgcttggt atgcacggta acctggggcc caatatcaat
     4081 accaataaat gtgatgtcct tatcgccgta ggcatgcgct ttgatgaccg tgtgacgggt
     4141 aaattggaaa catatgccaa gcaggcgaag attatccact ttgatattga ccctgccgaa
     4201 atagataaga atgtaaagac tgatgttgct gtcctgggag attgcaaaga gacactggct
     4261 gccgttaccc aattgctgga acccgccaac catcaggaat ggattgacag tttccggcaa
     4321 tacgaggaag tggaagagga aaaggtaatc cgtccggaat tacatccggc aggaaaagcg
     4381 ctaagcatgg gtgaggtggt gcgtgctgtg agtgaggcta cccataacga ggcgatattg
     4441 gtgactgatg tcggccagaa tcagatgatg tccgcccgtt atttcaaata cagcaaggaa
     4501 cgtagcattg ttacttccgg tggcctgggt actatgggct tcggccttcc ggcagctatc
     4561 ggtgccactt ttggacgtcc ggaccgcacg gtatgcgtat tcatgggaga cggcggcttg
     4621 cagatgaacc tgcaggaact gggtaccatc atggaacaaa aggctccggt gaagatgatt
     4681 ctgttgaaca ataacttcct gggcaatgtt cgtcaatggc aggcgatgtt cttcaatcgt
     4741 cgttattcgt ttactccgat gatgaatccg gattatatga agattgcttc ggcatatgat
     4801 attcctgcac gcagggtaat gacccgcgag gagctggcaa aagcgattga cgagatgata
     4861 gcgactgacg gaccattcct gctcgaagct tgtgtggagg aagaaggaaa tgtaatgccg
     4921 atgacacctc cgggcggttc ggtcaatcag atgttgttgg aatgctgaag tcatgcgaaa
     4981 ttaaagaatt tactctatct atggataaaa aactatatac aatcattgtt cattcggaaa
     5041 actttgccgg tttgctgaat caggtgacgg ctgtgtttac ccgccggcag ataaacatcg
     5101 agagtttgaa tgtatcggcc tcctccatca agggggtaca taaatatacc attaccgctt
     5161 ggacggataa ggataccatt gaaaaggtga ccaagcagat taccaagaaa atagatgtgc
     5221 tgcaagccca ttatttcacg gatgatgaaa tctatcagca cgagattgcc ctttataaaa
     5281 taacgacccc tacgctggaa gaaaaaccgg aggtgtccaa agtaatccgt aagtacaatg
     5341 cccgtattgt ggaggtgaat gctgtatttg ccattgttga gaagaatggc atgagtgagg
     5401 aaataaccaa tctttatgag gagttgcgcc agttggattg cgtacttcag ttcgtccgtt
     5461 cgggtcgcgt agccattacg accagctgct ttgagcgtgt caatgaatat ctggcggacc
     5521 gtgaagcaaa atatcgtcaa agtaaacacc aggaatcatg atgagcgaga acaataaaat
     5581 aggtacctac aagtttgttg ccgaaccgtt tcatgtcgac tttaccggac ggctgacaat
     5641 gggagtattg ggcaaccatt tgttgaattg tgcgggtttc catgccagcg accgcggttt
     5701 tggcatcgcg actctaaacg aggacaatta tacttgggta ttgtcccgtc tggctgtcga
     5761 actggatgaa atgccttatc agtacgaaga tttctccatt cagacttggg tggagaatgt
     5821 ctatcgcctt tttacagacc gtaatttcgc tatcatcgat aaggagggta agaagattgg
     5881 gtatgcacgt tccgtttggg cgatgattag catgaatacc cgtaagccgg cagatttgct
     5941 ggctcttcat agtggcagca ttgtagatta tgtttgcgat gagccttgcc cgatagaaaa
     6001 accttcgcgg ataaaggtgg cctcaaagga accggttgct gctttggtag ccaaatacag
     6061 tgatattgac attaacgggc atgtgaacag catccgttac atcgagcata tccttgattt
     6121 gttcccgata gagatgtata aggagaagcg catccgtcgt tttgaaatgg catatgtagc
     6181 cgaaagctat tatggggatg agttgacttt gttcatggat gatgccggtg agggcgttta
     6241 cgatgtggag gtgaaaaaga atggcagcga agtggtctgt cgctctaaag tgatatttac
     6301 agagaaataa ataaatttat caacgttggc gtaagccaca aataaaaatt aaaacaaaaa
     6361 atggcacaat tgaattttgg cggtgttatt gagaatgtaa tgacccgcga agaatttcct
     6421 ttggaaaaag cacgtgagat tttgaaagat gaaacaattg cagtaatcgg ttatggcgta
     6481 caaggcccgg gccaggcttg caacttgcgt gataacggtt tcaatgtgat tgtaggacaa
     6541 cgtccgggca agacatacga aaaggctgtg gctgacggat gggtgccggg tgagaccttg
     6601 ttcggcatcg aagaggcttg ccagaaaggt actatcgtca tgtgtctgtt gtctgatgcg
     6661 gctgtaatgt ctgtatggcc gactatcaaa ccttatttga ctcccggaaa ggctctttac
     6721 ttctctcatg gttttgctat tacctggaac gaccgcactg gtgtggttcc tcctaaagat
     6781 attgatgtta ttatggttgc tcccaaaggt tccggtactt cacttcgtac catgttcctc
     6841 gaagggcgtg gcttgaactc atcatatgcc gtctatcaag atgctacggg taaggctttt
     6901 gacaagacga ttgcactggg tatcggtatc ggttcgggat atttgttcga gacaactttc
     6961 atccgcgaag ccacttccga cttgaccggt gaacgcggtt cattgatggg tgctatccag
     7021 ggattactgt tggctcagta tgaagtattg cgcgaaaacg gccatactcc ttctgaagca
     7081 ttcaatgaaa cagtggaaga gttgactcaa tctttgatgc cattgtttgc caagaacggt
     7141 atggactgga tgtatgccaa ctgttctact acggcacagc gtggtgcgct ggattggatg
     7201 accccgttcc atgatgccat caagccggtt gtacagaaat tgtatgcaag tgtgaagtcg
     7261 ggcaacgaag cccagatttc tatcgacagt aactccaaac ccgattatcg tgagaagctg
     7321 aatgcagaat tgaaagcctt gcgtgaaagc gaaatgtggc agacagctgt tacagttcgt
     7381 aaacttcgtc cggaaaacaa ttaatcagct ttatataaat aggtgaaata ccctcttcgg
     7441 tgttaccgga gggggtattt ctttattatt gattccctat attttgaata aactccaata
     7501 gcttccggta aaaaccgtga tgtttcagcg tctctgcctc tcccaatatc accagcttca
     7561 tacgtgcccg ggtgatggct acattcattc tccttaaatc attcaggaat cctatctgcc
     7621 cttcttcgtt ggcacggaca aggctgatga agataacatc gcgctcttgc ccttggaagc
     7681 catccaccgt atttacagtg aacaagctgc gataaggctt gagtgaagcg tctgccttta
     7741 tcttgttgcg gagatattgc acttgtgcct tgtaagggga gatgatgccg aagtctattt
     7801 tttcttccag aatgcggttg ccactgatac ggttgatgta gattttcagt tctgatagga
     7861 gcaggtccgc ttccgcctta ttaatgcgcc cgaaagtctc tcccacaaat tcttctttga
     7921 aatccatttc ggaggtgtca atccagtgga tgggggtatc ccagtccagg atgccccggt
     7981 aacgcacttc ggaagcggct tccaactcgc cattataaaa ccattgggaa ggaaatttca
     8041 tgatttcctc gtgcatgcgg tattgcactt tcagcaaaga gacaacggca ggtttgttgg
     8101 acaccacttt ctccatcaat gttcgttcca gacctccacg ggcggcttcg tggcatttta
     8161 tggtgggcgg aagttggcag tggtcacccg ccaataccac gcggtctgct tttcggatag
     8221 ctatccagca ggcagcctct aaggcctggg ctgcttcatc aatgaaaagg gtgccgaaac
     8281 ggcgtccgtt cagcagccgg tgattgctgc ttaccagcgt ggaggctatg acgtgtgccc
     8341 catcaaaaag ctctgcattg atttgtattt ccaatgcggt ggcgcggtcg cgcaggcggc
     8401 tcatacggct gcgtactcct tcgcgttcgt catagctgcc acggcgggca cggctgccca
     8461 gttcacggag atttttccgg atgctccaca gttccggata aagcggatgg ttctcgaaac
     8521 gacgctcgta ggtaaaggaa agcatcttgt cgttgacacg ggtcggattg ccgatacgca
     8581 ggacattgac gccacggtct accagttttt ccgaaatcca gtcgacggca gtattgcttt
     8641 gggcacatac cagtacctgc ggttcccgat gcagggtttc gtagatggct tccactaagg
     8701 tggtcgtttt tccggttcct ggaggaccat gtacaatggc cacgtcgcga gcacacagca
     8761 ctttgtttac agctgtttcc tgcgtggagt tcagccaggg aaaccgtacg ggatagagct
     8821 ctcggaaacc ggctttcgag gttcccagca atatgtcccg caattcggcc aggcggttgc
     8881 ctttggagcg taacgtatct tccaaggctt cgaacatggt ccgataggat gtttcgtcga
     8941 aataaagttg cacgccgagg ttgtccgttt cctgcacttc cataacggca ccggctccgg
     9001 gcattatcgc taccatccgt gtctcgtcgg catagcttac ggtagcggtg aagttcatat
     9061 aggttatttt tccatcggca gactggcgga aaaaacatac gggacggccg aactcaaaat
     9121 tatgttctat atcggtattt tctgtgtgtg taatttctat tactaattga ttcagtgaat
     9181 tatagtaact tcgtcccgga gtggcaggat accagcaaag tccccgtttc actttccggg
     9241 caacccccat gttttcggtt tggcgtttga attcctcttt ttcgtattcg tattccatgc
     9301 gcagcaaaag ttgttgctgc tggaggtgaa taataggact atttgaatct tgttccttca
     9361 tggttgcaaa ggtaatcatt cttcgcttcc gacggaaaag atgctttatt ttgttaaact
     9421 attcagcctt tttatttgtt tatgatatta atttgtaatc tttacaataa tgaaaaacta
     9481 aaaaatagtg gttatggtat atgatttaac gatgctcaaa gcgttttatg ccgcttattc
     9541 ggagaagata gaacgtgtac ggaatgtact acagcgtccg atgactttag cggagaaaat
     9601 tttgtatgct catttgtatg atggggataa agtgaagaac tacagacggg gagaagacta
     9661 tgtgaatttc cgtcccgacc gtgtggccat gcaggatgca acggcccaaa tggccttatt
     9721 gcaatttatg aatgcaggcc gtgagcaggt tgccgtgcct tccactgtgc actgtgacca
     9781 tttgattcaa gcatataaag gtgcaaaaga agatgttgcg actgctacga agaccaacga
     9841 ggaggtctat aattttctcc gtgatgtttc ttcccgctat ggcataggtt tttggcagcc
     9901 gggagcaggc attattcacc aggtggtatt ggagaactac gcatttccgg gtggaatgat
     9961 ggtaggcacg gactctcata cgcccaatgc cggaggtttg ggcatggtgg ccattggtgt
    10021 gggtggtgcc gatgcggtgg atgtgatgac cggcatggaa tgggaattga aaatgccgcg
    10081 tctgataggc gtacacttga agggtaaatt gagtggctgg gtagctccca aagatgttat
    10141 tctgaagttg gcgggtattc ttacggtaaa agggggaacc aatgccatca ttgaatattt
    10201 tggaccggga accgcttcat tgtctgccac tggaaaggct accatctgca atatgggggc
    10261 agaggtgggg gcgactacct cccttttccc ttacgatgag cgcatgggta cttatttgaa
    10321 ggctaccgga cgtgaagaag tggcaaaaat ggctgcttcc gtagctgccg accttcgcgc
    10381 cgacgacgaa gtgctggcaa atccggaaaa atattacgac cgcatcattg aaatagacct
    10441 ctcgctgttg gaaccgtata tcaacgggcc ctttacgccg gatgcagcaa caccgatatc
    10501 gaaatttgcc gaggtagtga taaccaataa ctatccccgc cggatggaag tcggcctgat
    10561 agggtcgtgt accaattcgt cctatcagga tttgagccgc gcagcctccc ttgcccggca
    10621 ggtaaaggaa aagaatttga aggttgcttc ctcgctgatt gtcaaccccg gttcggagca
    10681 gatacgtgcc actgctgaac gcgacggcat gattgccgct ttcgaagata ttggcgcaac
    10741 gataatggcg aatgcctgcg gaccttgtat tggccagtgg aagcgccata ctgatgaccc
    10801 tgaacgaaaa aattccatcg tcacctcttt taaccgtaat tttgccaaac gtgccgatgg
    10861 aaatcccaac acttttgctt acgtcgcttc cccggagata acgatggcgc tgaccattgc
    10921 cggtgacctt tgtttcgacc cgttgaggga tacgctggtc aatgccaaag gagaggttgt
    10981 gaaactgtcc gaaccggtcg gtgaagaact gccggcacac gggtttatag gaggaaagga
    11041 aggatacatt gctccaggca aaggacagac ggaaattacg gtcaatcctc attcacagcg
    11101 cttgcaactg ctgactccct tccctgcctg ggatggcatg gacttgctga atatgccttt
    11161 attgattaaa gtgcaaggga aatgtaccac cgaccacatc tctatggcgg ggccatggct
    11221 ccgtttccgg ggacatttgg agaatatttc ggacaatatg ctgatggggg ctgtcaatgc
    11281 tttcaatgga gagacgaaca aggtttggaa ccgctccacc aatacctatg gaacagtgtc
    11341 aggcactgcg aagctgtata aatcagaagg catcccttcc attgtcgttg ccgaagagaa
    11401 ttatggtgaa ggttccagcc gtgagcatgc tgccatggaa ccacgcttcc tgaatgtacg
    11461 cgccattttg gcgaaaagct ttgcccgtat ccatgagacg aatttaaaga aacaaggcat
    11521 gttggcgctg acctttacgg ataaggccga ttatgacaag attcgggaac gcgacctgat
    11581 ttctgtcatg gggttgaaag attttgcttc gggacgtacg ttgaaggtgg ttcttcatca
    11641 cgaggacggg agtaaagaaa gttttgaagt acaacatacg tataacgaac agcagatagc
    11701 ctggttccgg gccggttctg cacttaatgc aagatagaat atggaaaaaa ttactgtacc
    11761 ttttattacc ggcgatggag tgggagcaga agtgacccca tccatgcagg ctgtcgtgaa
    11821 tgccgctgtc aagaaatcct atggtgaccg gcgtggcatt gaatggaaag aagtgctgg
//
