LOCUS       c00085_gnlPro..        12491 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|CIDLEMKA_85.
ACCESSION   c00085_gnlPro..
VERSION     c00085_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 05:54:59
            Original ID  :: gnl|Prokka|CIDLEMKA_85
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12491
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12491
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:5231]"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /neighbourhood="10000"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..5231
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /neighbourhood="10000"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protocluster_number="1"
     cand_cluster    1..12491
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(3, [Amidohydro_1, Amidohydro_3,
                     Arginase, FGase, Urocanase]) and Lyase_aromatic and
                     Urocanase_C)"
                     /kind="single"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12491
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="histidine2glutamate_hutHGIU_operon"
                     /region_number="1"
                     /rules="(minimum(3, [Amidohydro_1, Amidohydro_3, Arginase,
                     FGase, Urocanase]) and Lyase_aromatic and Urocanase_C)"
                     /tool="gutsmash"
     CDS             2..1135
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Urocanase_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Urocanase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_1"
                     /sec_met_domain="Urocanase (E-value: 4e-44, bitscore:
                     140.3, seeds: 148, tool: rule-based-clusters)"
                     /sec_met_domain="Urocanase_C (E-value: 9.5e-87, bitscore:
                     279.0, seeds: 88, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="EAEAFRLATDACRAKEPLSVAYHGNIVDLLEYAASESIPIDLLSD
                     QTSCHAVYEGGYCPAGISFEERTRLLSEDQETFCALVDRSLRRHYEVIKRLVEGGAYFF
                     DYGNSFLKAIYDAGVKDISRNGIDEKDGFIWPSYVEDIMGPELFDYGYGPFRWVCLSGK
                     KEDLVKTDHAAMDCIDPDRRGQDRDNYNWIRDAEKNNLVVGTQARILYQDAEGRLKIAL
                     RFNQMVRDGEIGPVMLGRDHHDVSGTDSPFRETSNIYDGSNVMADMAVQCFAGNAARGM
                     SLVALHNGGGVGIGKAVNGGFGMVLDGSNRVDEILRSAMLWDVMGGVARRAWARNRHAL
                     ETSETFNKNNENQYHITLPYIPEEELIRKTIKTSLNT"
     CDS             1140..2042
                     /locus_tag="ctg85_2"
                     /transl_table=11
                     /translation="MSSWNKIMECVPNFSEGRDLGKIEKIIEPFRARQGVKLLDYSNDE
                     DHNRLVVTVVGEPEALKAALLEAVGQAVALIDLNRHVGQHPRMGAVDVIPFIPIKGCAM
                     DEAIALSKEVGEQIATLYQVPVFLYEKSATAPHRENLAAVRKGEFEGMAEKIKLAEWQP
                     DFGPAERHPTAGTVAVGARMPLVAYNVNLGTADLNIASDIARKIRFIGGXXXCKAMGVE
                     LKERGIVQVSINMTDYTRTALYRAFELVKIEARRYGVAVVGSEIIGLVPMEALIDTASF
                     YLGLENFSMNQVLEARIME"
     CDS             2046..2795
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Amidohydro_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_3"
                     /sec_met_domain="Amidohydro_3 (E-value: 8.2e-11, bitscore:
                     31.4, seeds: 42, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKGDKLLIRNASQVVTCSGFEAKRGTAMSDLHIIEDGAVVVSEGV
                     ITHVGPTKEIVRQVDPDEYLEIDASGRALLPGFVDSHTHFIFGGYREEEFSWRLKGDSY
                     MSIMERGGGIVNTVNATRERDFEQLWSIGYERLDEMLDMGVTTVEGKSGYGLDFETELM
                     QLRVMADLNEEHPVDVVSTYLGAHAVPPEYTHQTDDYITYMIEQVLPELRLERTVTFCD
                     VFXXXXSVPIICCTLRMKASNGWHAAG"
     CDS             2792..3169
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Amidohydro_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_4"
                     /sec_met_domain="Amidohydro_1 (E-value: 1.7e-20, bitscore:
                     63.1, seeds: 57, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VIATLLPLTAFSLNEPYARGREMIDAGCAVALATDYNPGSCFSCS
                     IPMLFALACIQMKLTPEEAVTALTINGAAALGRANKIGSIDVGKKADLILLKYPSYKFL
                     PYNVGMNIVDTVIKDGIIYMI"
     CDS             3280..3732
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) FTCD_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg85_5"
                     /sec_met_domain="FTCD_C (E-value: 7.6e-42, bitscore: 132.6,
                     seeds: 242, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTIATEAALIRERLIRDIDRDSEAYDRVFAAFKLPKETEEQIVE
                     RAQAIEDATKEAAIVPMQVAEEIASVMETVIYVAHKGNRNAVTDACVAMMTARTCVLGA
                     LLNVRINLASIKDEAFVKQMKVKADHLESEAIRIETKLLDWVKTIV"
     CDS             3734..4501
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Lyase_aromatic"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_6"
                     /sec_met_domain="Lyase_aromatic (E-value: 3.5e-84,
                     bitscore: 272.5, seeds: 479, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNVYYVGSEPLTFDSIELILTQNMKLELSQEVRERIQRCRDYLD
                     RKIEQQDGPLYGITTGFGSLCNKNISPDELSTLQENLVKSHACSVGDEVSPVIVRLMML
                     LKAHALSLGHSGVQVITVQRILDFFNNDVLPIVYDRGSLGASGDLAPLANLFLPLIGVG
                     DVYYKGKKREAISVLDEFAWKPVRLKSKEGLALLNGTQFMSANGVFALMRAFRLSQKAD
                     TIAALSLEAFDGRIDPFMXXXXYPADASSSGTD"
     CDS             4476..5231
                     /gene_functions="biosynthetic (rule-based-clusters)
                     histidine2glutamate_hutHGIU_operon: Lyase_aromatic"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg85_7"
                     /sec_met_domain="Lyase_aromatic (E-value: 1.4e-89,
                     bitscore: 290.3, seeds: 479, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRPHPGQIETGAAFRRLLEGSELINRKKEHVQDPYSFRCIPQVHG
                     ATKDAINYVSGVLLTEINSVTDNPTIFPEEDKIISGGNFHGQPLAISFDFLAIALAELG
                     NISXXXVAQLIMGLRGLPEFLVANPGLNSGFMIPQYAAASMVSQNKMYCYAASSDSIVS
                     SNGQEDHVSMGANAATKLFKVMDNLDHILAIELMNAAQGMEFRRPARTSPVLEKFLRDF
                     RKEVPFIEDDIVMYTEIHRTVAFLRRYPL"
     CDS             5587..6183
                     /locus_tag="ctg85_8"
                     /transl_table=11
                     /translation="MDISIRQLRNSNEQMFKSIVESYWPRLHKFAQIYVLDREVAKEIV
                     QDTFLVLWKQREKLDKETCLITYLMVICRNKCFNYLKGLQLEQVEINDLNEFAIYQRSN
                     VYVLENDSLEILMTKELASAIEASLSKLSARTRDIFMMSRYDGFKNKEIAESQCITVKA
                     VEFHINKALSHLRDDLSKEYLIPIIFLILYIGLKK"
     CDS             6455..7516
                     /locus_tag="ctg85_9"
                     /transl_table=11
                     /translation="MLLLELIXXXXXXXXXXXXXXXXXXXXXTEKVSPEDVRKIMKEIS
                     RKRYRLLPYAAAVVCAVVAVLLFIISPLNERNLSEYEKVLAGIEDKKEITLTVNNDKEI
                     ELSDTSIVVTYDKKGQILINDTVAVPGEKENLDHLNMIRVPYGKRSTLILADGSKVYLN
                     SGSSLVYPAVFAKDKREVYLDGEAYFEVSKEARRKFVVQTAYKAVEVLGTKFNVSVDKR
                     QSLFEAVLVTGKIGLESNTGKIELIPNQYYGYDPDSGQDELKTVDTRDYISWIEGRLRF
                     NREPLDKVIHRLEKSYNIKIEILDSKYLKYQISGNLDLKSTPEETMNVLMRILIMKAYV
                     IKKLLFNKKNLSL"
     CDS             7513..11043
                     /locus_tag="ctg85_10"
                     /transl_table=11
                     /translation="MRKKTSTSKAGPCGRASWRRFLVVGLCSCVSLTMYANVLKSQVSL
                     SFNNTTLKDALEQLQEQAGVSIIYSNNVLNDEAVVNLNSKKISLEDALHILLLNQNCSY
                     KVENGQVILYPVEKVQPAVTVVAQEGFKVKGSVSDVTGPLAGVNIMVKGTMTGVISDMD
                     GNFEITAPYSGASLIFSYIGYQPQEVQINGRNTLKITLVEDTKALEEVVVIGYTTQKKA
                     TITGSISTITTKDLKQSPTANLNNALAGRMPGLMANQFGGGEPGVDGAEIRIRGMGTYG
                     DKSPIVIVDGVERDMSYLAPEEIETFTILKDASATAPYGVRGANGVIIVTTKRGKASEK
                     PSVNFKASVGTNAPVKFPTYLGSADYATLYNEAMINSNPRTDPSKLELFTQDAINNYRM
                     AKGDNSDGLGYNWDYFDYAFKPGIQQDYSLSIRGGSERARYYVMANYYSQDGNYEHTDL
                     TEHDTQARFKRYNFRANVDVDITKDFYVRVDLGARITDRHAPGTTASTVVSLCNTLPPY
                     LPITVPENDNPDNEDYVLNNPYGMLYGDYRHRKNILGELSRTGYLIEKKTYLNGSFAIG
                     HKLDFITKGLKIEGVFSYDASEGNWVNRKLGVNKDGYMEFTKYATFQPAEGSYGSFYMN
                     NPNYTGKYILGNPWYDKDETIENTFSHNAAESKTYYQLKLDYARTFNDHDITAMVLLNR
                     SNRSYDNRVAYRYQGLTARATYAFQNKYLAEFNIGYNGSENFAPGKRYGTFPAGSIGWV
                     ISREKFMKGTDKWLSNLKLRASYGLVGSDKISDNNDDRFAYLQFFQGGDGYSYGVNEFG
                     NGYNGLKEGNFANPNLTWEKARKLNIGIDASFFNERLTFSADYFYEHRFDIITNLSNSG
                     KLGYPGIVGKDAPFVNSGIVDNRGIDFEIGWNGSIGDDFRYYIKPNFTFARNKIKFMNE
                     VSYDNDWRANTGKRIDEYFVYEVDHFVYDQAEADRLNSMNNGEGFQPWGTLYPGDVVYK
                     DLNGDGKIDDEHDRRAMGNPRTPEIQFGIPLGLQYKGFDLSLLFQGAANSSILLNGAGV
                     WDFPQYDNDQIGKVKPMHMNRWTEESKDFATYPRLTIGKNDNNKNENSSLFLYNASYLR
                     LKNVEIGYTLPKSAIRFAGLQNVRFYVQGMNLLTFDGLDHVDVDPETNNGNGAWYPIQR
                     IFNFGVDITY"
     CDS             11061..12491
                     /locus_tag="ctg85_11"
                     /transl_table=11
                     /translation="MKKLYILAGLVVGLLCVTSCDDYLDRTPDDKTTEQQVFTRYDKVE
                     SLVTDLYAHAKYAQHPLIYFNHFGLSSISDECSASSHEGAIPHQFHTGNYGPSQGMPSG
                     SSAGQYWDDLYSTIRSSNIILEGIAKYNTPDNPQDGRTGDLKRRIGEVYFLRGYLHLLL
                     IRSYGEAVYVNRVINPGDDMTFEKESFHSMVEKICADADSAYNRVDSWNGGQYFGRVDK
                     GACLGLKAMARWLAATPLWNGGNLPNDNRIFKSEYGYDQKRWELARDAAKAVLECTKED
                     GSLRYKLYETYTKDDFRDVDGKTDTNNKKVQQRLWQMMYDMNAIQDEWVWFVTRDKDTG
                     WSGDVLPPSQGGHARQRPLQEQVDEYEYIAPDGYGYPIYCNHAEKDGYDDGNPYEGIQR
                     DPRLYRDIRYHGSWYGGNQLNTAEGNDAVGGSYLDQASHTGYYLRKFYKDGWDRGHGGH
                     TINGPAIWRLPEFIYMYCE"
ORIGIN
        1 cgaggccgag gcttttcgcc tggctacgga tgcttgccgt gccaaagagc ctctttcggt
       61 tgcttatcat gggaatattg tagacctgtt ggaatatgcc gcatcggaat ctattcctat
      121 cgacttgctg agcgaccaga cttcgtgtca tgctgtttat gagggtggat actgtcccgc
      181 aggaatctct ttcgaagaac gtacgcgttt gctttcggaa gaccaggaaa cgttttgtgc
      241 cctggtggac cgttctttgc gcagacatta tgaagtgata aaacggctgg tcgagggcgg
      301 agcctatttc ttcgattacg gcaattcatt cctgaaagcg atttatgatg ccggtgtaaa
      361 agatatatcc aggaatggta tcgatgagaa agatggtttt atctggccgt cttatgtgga
      421 agatataatg ggaccggaat tatttgatta cggctacggt cctttccgct gggtttgtct
      481 gagcgggaaa aaagaagacc tggtcaaaac cgaccatgcc gccatggatt gtattgatcc
      541 ggaccggcgg ggacaggacc gtgataacta caactggata cgcgatgccg aaaagaacaa
      601 tctggtagta ggtacacagg cccgtatcct ttatcaggat gccgaaggca ggctgaagat
      661 tgcacttcgt ttcaatcaga tggtccgtga cggagagatc gggccggtga tgctgggacg
      721 cgaccaccat gatgtcagcg ggacagactc gcctttccgg gagacgtcca atatctacga
      781 cggtagtaac gtcatggccg atatggctgt acagtgtttt gccggaaatg cagcccgcgg
      841 aatgagtctg gtagcccttc ataatggtgg tggtgtcggt atcggtaaag cggtaaacgg
      901 aggattcggt atggttctcg acggaagtaa ccgtgttgat gaaatattac gttctgccat
      961 gttatgggat gtaatgggcg gtgtggcgcg ccgtgcctgg gcacgtaacc ggcatgctct
     1021 ggaaacaagt gaaacattta ataagaataa tgagaatcag tatcatatca ctcttcctta
     1081 tattccggag gaagaattga tacgaaaaac aataaagacc tctttaaata cctgaattta
     1141 tgagtagttg gaataaaatt atggagtgtg tccccaattt tagtgaaggt agggacttag
     1201 ggaagataga aaagattatt gagccgttca gagccaggca aggagtaaaa ctgttggatt
     1261 atagcaatga tgaagatcat aaccgcctgg tcgttactgt agtcggtgaa ccggaggcgt
     1321 tgaaagccgc cctgttggag gctgtaggac aggcggtcgc tttgatagac ctgaaccggc
     1381 atgtcgggca acatccgcgg atgggagctg tcgatgtgat cccgttcatc ccgatcaaag
     1441 gatgtgcaat ggatgaagcg attgctttat ctaaagaagt tggtgaacag attgcaacct
     1501 tataccaggt ccctgtgttt ttatatgaga agtcggcaac cgcccctcac agggagaatc
     1561 tggcagcagt caggaaaggt gagttcgaag ggatggctga gaagattaaa ctagcagaat
     1621 ggcagccgga tttcggaccg gcggagcgcc acccgacagc cggtacggtt gccgttggtg
     1681 cccgtatgcc gcttgttgcc tataacgtca acctgggtac ggccgatttg aatattgcca
     1741 gcgacattgc ccgtaagatc cgttttatcg gcggnnnnnn nnnntgtaaa gcaatgggag
     1801 tcgaactgaa agaacggggt atcgtgcagg tctcgattaa tatgaccgac tatactcgta
     1861 cggccttgta ccgcgctttt gaactggtga agatagaggc tcgccgttat ggtgttgcgg
     1921 ttgtaggtag tgagattatc ggattggttc cgatggaagc attgattgat acagcttctt
     1981 tctatttagg gttggaaaac ttttccatga accaggtgtt agaagctaga ataatggaat
     2041 aaaacatgaa aggagataaa ttactgataa ggaacgcatc gcaagttgta acctgttccg
     2101 gttttgaagc aaaaagaggg acggcaatgt ctgatctcca tattatagaa gatggagcag
     2161 tggttgtttc cgaaggtgtt ataacgcatg tcggtccgac aaaagaaata gtacgtcagg
     2221 tagatccgga cgaatacctg gaaatcgatg ccagtggaag ggcattgctt cccgggtttg
     2281 tggatagtca tacccatttt attttcggtg gttatcgtga agaagagttt tcctggcggt
     2341 tgaaaggcga cagctatatg tcgatcatgg agcgtggcgg tggtatagtc aatacggtca
     2401 atgccacccg tgaacgtgat ttcgagcaac tgtggagtat cggttatgaa cggctcgacg
     2461 aaatgttgga catgggcgta acgacggtgg aagggaagag tggatatggt cttgatttcg
     2521 aaaccgaact gatgcagttg cgtgtaatgg cagacctcaa cgaggaacat ccggtcgatg
     2581 tcgtgtctac ttatttggga gctcatgccg ttccccctga atatactcat cagacggatg
     2641 attacattac ttatatgatc gaacaggtcc tgccggaact tcgtctggag agaacggtta
     2701 ctttctgtga tgttttttgn nnnnnnnnnt cagtgccgat catttgctgc acgcttcgga
     2761 tgaaggcatc caacggttgg cacgcagcgg ggtgattgcc accttgcttc cgctcaccgc
     2821 cttttcgttg aacgaacctt atgcccgtgg ccgtgagatg attgacgccg gttgtgcagt
     2881 tgcgctggct accgattata atcccggcag ttgtttttcc tgttctatcc cgatgctatt
     2941 cgctttggcg tgtattcaga tgaaactgac tccggaagag gcggttaccg ctttgacgat
     3001 taacggggcg gcggctctgg ggcgtgctaa taagatcggc agcatagatg taggaaagaa
     3061 ggccgacctg atcctgctga aatatccgtc ctataaattc cttccttata atgtgggaat
     3121 gaatatcgtg gatacggtga ttaaggacgg aatcatttat atgatttgag aaacagttta
     3181 ttcattgttt aataccttaa atataaatac nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     3241 nnnnnnnnnn nnnnnnnnnn nnnnnnnnng gaagggcaga tgaaaacgat agctacggaa
     3301 gcggccctga tccgtgagcg cctgatccgc gacatcgacc gtgacagtga agcctacgat
     3361 cgtgtgtttg ccgcctttaa acttccgaaa gaaacggaag agcagatcgt cgaacgtgcc
     3421 caggccattg aagatgccac gaaagaggcg gctattgttc ctatgcaggt tgccgaagag
     3481 atcgcgtctg tgatggaaac cgtcatttat gtggcacata aaggaaaccg gaatgccgtt
     3541 accgatgctt gtgttgccat gatgactgcc cgtacctgtg tcttgggagc cctgctgaac
     3601 gtacgtatca acctggcttc catcaaagac gaagcttttg taaagcagat gaaagtgaaa
     3661 gccgaccatc tggaatcgga agcgatccgt attgaaacga agttactgga ttgggttaaa
     3721 acaatagtat aacatgagca atgtctatta tgtaggttcc gaaccgctga cattcgacag
     3781 cattgagttg atcctgactc agaacatgaa gctcgagtta agccaggaag tgcgcgaacg
     3841 catccagcgt tgccgcgatt acctggaccg gaaaatcgaa caacaggatg gtccgcttta
     3901 tggcattaca accggcttcg gctcgttatg caataaaaat atctcgcccg acgaactgag
     3961 taccttacag gaaaacctgg tgaaaagcca tgcctgtagt gtcggtgacg aggtgagtcc
     4021 cgtcattgtc cggttgatga tgctgctgaa agcacatgct ttgtctttgg gccatagcgg
     4081 tgtacaggtt attaccgtac aacgtatcct cgatttcttc aataatgatg ttctgccgat
     4141 cgtttatgac cggggctccc tgggagcttc cggcgatctg gctccgttgg cgaatctctt
     4201 cctgccgctg atcggagtgg gagatgttta ttataaagga aagaagcgcg aagcgatcag
     4261 cgtattggat gagtttgcct ggaagcccgt acgcctgaaa agtaaagagg gactggcttt
     4321 actgaatgga acacagttta tgagtgcaaa tggcgttttt gccctgatgc gtgcttttcg
     4381 tctttcccaa aaggcggata cgatagcggc cttgtctttg gaagccttcg acggtcgtat
     4441 cgatcctttt atggnnnnnn nnnngtatcc agcagatgcg tcctcatccg ggacagattg
     4501 aaacgggagc agctttccgc cggttgttgg agggaagcga actgatcaac cggaaaaagg
     4561 agcatgtgca ggacccttat tccttccgtt gtatcccgca ggttcacgga gcgacaaagg
     4621 atgcgatcaa ttatgtttcc ggcgtattgc ttacggagat taattcggtg acggataatc
     4681 cgaccatctt cccggaagaa gacaagatca tctcgggtgg taatttccat ggtcagccat
     4741 tggccatttc tttcgacttt ctggccatcg ctttggctga attaggaaat atatcnnnnn
     4801 nnnnngtcgc ccaattgatc atgggacttc gcggtttacc ggaatttctt gtagccaatc
     4861 ccggactaaa ctctggtttt atgatcccgc aatatgctgc tgcaagcatg gtcagccaga
     4921 ataagatgta ttgttatgcc gccagcagcg attcgatcgt atccagcaat ggtcaggaag
     4981 atcatgtcag catgggagcc aatgctgcaa ccaaactatt caaggtaatg gataatctcg
     5041 atcatatcct ggcgattgaa ttaatgaatg cggcacaagg aatggagttc cgccgtccgg
     5101 ccaggacttc acctgtcctt gaaaaattcc tgagagactt ccggaaggag gtccctttca
     5161 tagaggatga tattgtaatg tacacggaga tccatcgtac ggtggctttc cttcggaggt
     5221 atccgttgta gttacgctga tcgtagatag ttcagctata tgttttgaga gacctttgtt
     5281 tctgaattat ccgtgtggat atggcctgat tgtagagccg aagcttttga atataaagct
     5341 tcggctctaa ttttttatga gaatttaact gacnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5401 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     5461 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntc atataaagaa aatccactgt
     5521 tacagaggtt tgtatttata tttttggctt tgattgtgta atagaattct aagtagacgc
     5581 tttctgatgg atataagcat acggcaatta agaaatagta atgagcaaat gtttaaaagt
     5641 attgtagaat cttattggcc ccgtttacat aagttcgccc agatttatgt attggataga
     5701 gaggtggcca aagagattgt gcaggatact ttccttgttt tgtggaaaca acgggaaaaa
     5761 ttggacaaag agacctgtct aataacttat ttaatggtga tatgccggaa taaatgtttt
     5821 aattatttga aaggtttaca attggagcag gtcgagatta atgatttaaa tgagtttgct
     5881 atttatcaaa gaagtaatgt ttacgttttg gaaaatgatt cgttggaaat actgatgaca
     5941 aaagagttgg catcggctat agaagcttca ttatcgaaat tatctgcacg tacaagagat
     6001 atttttatga tgagccgtta tgacggtttc aaaaacaaag agatagccga aagtcagtgt
     6061 ataacggtta aagctgtcga gtttcatatc aacaaggccc tgagtcattt gagagatgat
     6121 ctgtccaaag aatatctcat tcctattatt tttttgattt tgtatatagg attgaaaaaa
     6181 taattgtatt gtttgtatgt ctgattatca aagttttatg gtgttgctat gaaaaaactt
     6241 accaaaaagt gaaaaaaatc tccattttct actagggtaa aattaaaaaa agttgttcct
     6301 cctctgtctg gtatcaaaag atagattatg aacaacgatt tagttatacg atttatagaa
     6361 agacagtgca caatagaaga agcgcgtgaa gttctgcgct ggattgaggc aactgaagag
     6421 aacaaggctg ttttctgtca aatgcaggct gtacatgctt ctattggaat tgatcannnn
     6481 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnngtac
     6541 agaaaaagta agcccggaag atgtccggaa gataatgaaa gaaataagcc gcaaacggta
     6601 tcggctatta ccttatgccg ctgcggttgt ttgtgctgtt gtggctgtcc tgttatttat
     6661 tatctcccct ttgaatgaaa gaaatcttag tgaatatgaa aaagtcctgg ccggaattga
     6721 agataaaaaa gagattactc tgactgtcaa caatgataag gagatagaat tgtctgatac
     6781 ttcgattgtt gttacgtatg ataaaaaagg acaaatcctg attaatgata cagtggctgt
     6841 tcccggggag aaggagaatc ttgatcattt gaatatgatc cgtgttcctt acgggaagcg
     6901 ttccactttg attctggctg atggttccaa agtgtatctc aattctggtt cgtcattagt
     6961 ctatccggct gtgtttgcca aagataaacg tgaagtttac ctggatggtg aggcctattt
     7021 tgaagtatcg aaagaagcac ggcggaaatt tgttgtgcaa acggcttata aagcagtgga
     7081 agtattgggg acgaagttta atgtatcggt cgataaaagg caaagcctgt ttgaagcggt
     7141 attggtgact ggtaaaatcg gtttggaaag taataccggc aaaatagaac ttatcccgaa
     7201 ccaatattat ggttatgatc cggattccgg acaggatgag ctgaaaacag tagataccag
     7261 ggattacatt tcctggattg aagggagact ccgatttaat cgtgagcctt tggataaagt
     7321 aatccatcgg ttagagaaat cttataatat aaaaatagaa attcttgatt ctaaatacct
     7381 caaatatcaa atatcgggta atctggattt gaaaagtacg ccggaagaga caatgaatgt
     7441 tctgatgagg attctgatta tgaaagccta tgtaattaaa aaattattgt ttaacaaaaa
     7501 gaatctatca ttatgagaaa gaagacaagc actagtaaag ctggtccatg cggacgagca
     7561 tcctggagaa ggttcctggt tgtaggtttg tgtagttgtg tttcattgac aatgtatgcc
     7621 aatgtattaa agtcacaggt aagtttatcc ttcaataata ctacattgaa ggatgctctg
     7681 gaacaacttc aggaacaagc gggagtgagt attatttatt cgaacaatgt gttgaatgat
     7741 gaggcggttg taaatcttaa ttccaaaaaa atttcattgg aagatgcttt acatattttg
     7801 cttcttaatc agaattgctc gtataaagtg gaaaatgggc aggttatatt gtaccctgtg
     7861 gagaaagtac aaccggcagt cactgtagtc gctcaagaag gttttaaggt aaaaggtagt
     7921 gtttctgatg ttacaggtcc tttggctggt gtaaatatta tggtaaaagg aactatgaca
     7981 ggtgttatat ctgacatgga tggtaatttt gaaattactg ccccttattc aggagctagt
     8041 ttgatttttt cttatatcgg ttatcaacct caggaggtac agataaatgg acgaaatact
     8101 ctaaaaatta cactggtgga agatactaaa gctttggaag aagttgttgt cataggttat
     8161 actactcaga aaaaagcaac aattactggg tctatatcga ccataactac caaagattta
     8221 aagcaaagcc cgaccgcaaa cctgaataat gccctggcgg gtagaatgcc tggtttgatg
     8281 gctaatcagt ttggtggtgg tgaaccaggt gtggatggag cagagatacg tatccgtggt
     8341 atgggtacat atggagacaa atctccgatt gtcattgtag atggtgttga acgcgacatg
     8401 agttatctgg ctcctgaaga aatcgagact tttacaattt tgaaggatgc ttctgcaact
     8461 gctccttatg gtgttcgtgg tgctaacggt gttatcattg ttacgactaa acgtggtaaa
     8521 gcttctgaaa agcctagtgt gaattttaag gcatcggtag ggacaaatgc tccggttaaa
     8581 tttcctactt atttaggatc tgcggattat gcaaccttat ataatgaagc tatgataaat
     8641 agtaatccca gaacagatcc ttcaaaactt gagttgttta cgcaggatgc tattaacaat
     8701 tacagaatgg ctaaaggaga taattctgac ggtttaggct ataactggga ctattttgat
     8761 tatgcgttta aaccgggaat tcaacaggat tatagtttgt ctatccgagg aggttctgag
     8821 cgtgcgcgtt attatgtgat ggctaattat tattctcagg atggaaacta tgagcataca
     8881 gatttgacgg aacacgatac tcaggctagg tttaagcgtt ataacttccg tgcaaatgtc
     8941 gatgtcgata ttacaaaaga tttttatgtg cgggtagatt taggcgctcg tattacggat
     9001 cgtcatgctc cgggaacaac agcatctaca gttgttagtt tatgtaatac gttgcctcct
     9061 tatttgccga taacagtacc tgaaaatgat aatcctgaca atgaagatta tgtattgaat
     9121 aatccatacg gcatgttgta tggggattat aggcatcgta aaaatatttt aggagagtta
     9181 tcaagaaccg gatatctgat tgagaagaaa acttatctga acggatcatt tgcaatcgga
     9241 cataaacttg attttataac aaaaggattg aaaattgaag gagttttctc ttatgatgcc
     9301 tctgaaggta actgggtcaa tcggaaacta ggtgtcaata aagatggtta tatggagttt
     9361 actaaatatg ctacattcca gccagcagaa ggtagttacg gttcatttta tatgaataat
     9421 ccgaattata cgggtaaata tatattagga aatccttggt atgacaaaga tgagacaata
     9481 gagaatacat ttagccataa tgcagctgaa agtaagacct attatcagtt aaaactagat
     9541 tacgcacgta catttaatga tcatgatatt acggctatgg ttttgttaaa tcgttcaaac
     9601 cggagttatg ataaccgtgt tgcttatcgt tatcaggggc tgacagcaag agcgacatac
     9661 gcttttcaga ataaatattt ggcagagttc aatattggat ataacggttc tgaaaacttt
     9721 gcaccgggta aacgatacgg aacatttcct gccggatcta tcggatgggt tatttcccgg
     9781 gaaaaattta tgaagggaac tgataaatgg ttgagcaatc ttaaattgag agcttcttat
     9841 ggtttagttg gtagtgataa aatttctgat aataatgatg accgttttgc ttatttgcaa
     9901 ttttttcagg gaggagacgg ttattcgtat ggtgtgaatg aattcggaaa tggatacaac
     9961 gggttgaaag aggggaattt tgcgaatccg aatttaactt gggaaaaagc acgtaagttg
    10021 aatattggta ttgacgcttc tttctttaat gaacgtctga ctttctcagc tgattatttt
    10081 tatgaacatc gttttgatat tataactaac ttaagtaatt ccggaaaatt gggatatcca
    10141 ggaatagtcg gaaaggatgc accatttgtt aactcaggta ttgtggataa tagaggtata
    10201 gactttgaga tcggctggaa tggtagtata ggagatgatt tccgttatta tatcaagcca
    10261 aatttcacat ttgcacgaaa taagatcaaa ttcatgaatg aagtatcgta tgataatgac
    10321 tggcgtgcaa ataccggaaa acgtattgat gaatattttg tttatgaagt agaccatttc
    10381 gtgtatgacc aggcggaagc tgatcgtttg aactctatga ataacgggga aggtttccaa
    10441 ccttggggaa cgttatatcc aggtgatgta gtttataaag atttgaatgg agacggaaaa
    10501 atagatgacg aacatgaccg tcgtgcgatg ggaaatcctc gtacaccgga aattcaattt
    10561 ggtattcctc ttggtctcca gtataaaggt tttgacttga gtctgttatt tcagggagct
    10621 gccaactcaa gcattttgtt gaacggtgca ggtgtatggg atttcccaca gtatgataat
    10681 gaccagattg gtaaggtaaa accgatgcac atgaaccggt ggactgaaga aagcaaagat
    10741 tttgcaactt atcctcgttt gacaattgga aagaatgaca ataataagaa tgagaacagt
    10801 agcttattct tatataatgc ttcttatttg cgtttgaaga atgttgagat tggatatact
    10861 ttacccaaaa gtgctattcg ctttgccggg ttgcagaatg ttcgttttta tgtacaaggc
    10921 atgaacctgc ttacttttga tgggttggat catgtggatg ttgatcctga aacaaataat
    10981 ggaaacggtg cttggtatcc tatccagcgc atattcaatt ttggtgttga tattacttat
    11041 taatttaata acaaacgaca atgaagaaat tatatatatt agccggcttg gttgtaggat
    11101 tattatgtgt gacatcctgt gatgattatt tagaccgtac tccggatgac aaaacgacag
    11161 aacagcaagt tttcacacgt tatgataaag tcgagtcatt ggttaccgac ttatatgcac
    11221 atgcaaaata tgcacagcat ccattgattt actttaatca tttcggtttg tcgagtattt
    11281 cggatgaatg tagtgcaagt agccatgaag gggcaattcc acatcaattt catacaggta
    11341 attatggtcc ttctcaagga atgccctctg gcagtagcgc aggacaatac tgggatgatt
    11401 tgtattctac tattcgctct tctaatataa tattggaagg tattgcaaaa tacaatacac
    11461 cggataatcc gcaggatgga cgaacgggag atttaaaaag gcgtattggt gaagtttatt
    11521 ttttgagagg ttatttgcat ttacttttga tccgttctta tggtgaagct gtttatgtca
    11581 atcgtgtaat aaatccgggg gatgatatga cttttgagaa agaatcgttc cattcgatgg
    11641 ttgaaaaaat ctgtgcagat gctgattcgg cttataatcg tgttgatagt tggaatggag
    11701 gacaatactt cggtcgtgtc gataaaggag catgtttggg cttgaaagct atggctcgtt
    11761 ggcttgcagc tacacctctt tggaatggtg gtaatttacc gaatgataat cgtatcttca
    11821 agtccgaata cggttatgac cagaaacgtt gggaattggc aagagatgca gctaaggctg
    11881 tattggagtg cacaaaagag gacggctctt tacgttataa attatacgaa acctatacaa
    11941 aggatgactt cagagatgtt gatggtaaaa ctgatacgaa taataaaaaa gtccagcaac
    12001 gtttgtggca gatgatgtat gatatgaatg ctatccagga tgaatgggtt tggttcgtaa
    12061 caagagataa agatacgggc tggtccggcg acgtattgcc tccgtcacaa ggaggtcatg
    12121 cccgtcaacg acctttgcag gaacaggttg atgaatatga atatattgct ccggatggat
    12181 atggttatcc tatctattgc aatcatgcag aaaaagatgg atacgatgat ggcaatcctt
    12241 atgagggcat tcaacgtgat cctcgtttgt atcgtgatat tcgttatcat ggttcctggt
    12301 atggaggtaa ccagttgaat acagctgaag gtaatgatgc ggtcgggggg agttatttgg
    12361 atcaggcttc tcatacgggg tattatttga gaaagttcta taaagatggt tgggatcgtg
    12421 gtcatggtgg ccatactatt aacggaccgg ctatttggcg cttaccggaa ttcatttata
    12481 tgtattgtga g
//
