LOCUS       c00052_gnlPro..        16324 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PCOFJJCD_52.
ACCESSION   c00052_gnlPro..
VERSION     c00052_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 06:11:57
            Original ID  :: gnl|Prokka|PCOFJJCD_52
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16324
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16324
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3863:10326]"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC,
                     Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical
                     or Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_unknown"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3864..10326
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC,
                     Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical
                     or Gly_430_pcre or Gly_8-9_TMA))"
                     /neighbourhood="10000"
                     /product="OD_unknown"
                     /protocluster_number="1"
     cand_cluster    1..16324
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(1, [PFOR_II, POR, POR_N]) and
                     minimum(2, [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC,
                     Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical
                     or Gly_430_pcre or Gly_8-9_TMA))"
                     /kind="single"
                     /product="OD_unknown"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16324
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="OD_unknown"
                     /region_number="1"
                     /rules="(minimum(1, [PFOR_II, POR, POR_N]) and minimum(2,
                     [CoA_binding, CoA_binding_2, Ligase_CoA, PTAC,
                     Succ_CoA_lig]) and not (Gly_radical_scatole or Gly_radical
                     or Gly_430_pcre or Gly_8-9_TMA))"
                     /tool="gutsmash"
     CDS             2..226
                     /locus_tag="ctg52_1"
                     /transl_table=11
                     /translation="LPVGMKNMAEHRNRPLKQRTIGIFDRYTENYAYLRSRKQGFFEMA
                     EAKSGSIPLRFHHRIDTKKGQRIGSKITS"
     CDS             360..2642
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_2"
                     /sec_met_domain="Peptidase_M22 (E-value: 1.5e-09, bitscore:
                     27.8, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKNKVYALIIQGLVQGVGFRPFIYRIAKDLGMKGCVENMNNGVR
                     ILVAATPDDRDLLISRIRTEHPRVAYIHRISYTSTEMDEDDFDDFTITPSHSESDEVTQ
                     VSPDIAVCADCMRDRTTQPHRIGYPFINCTHCGPRFSIIRDLPYDRSQTTMGGFLMCPD
                     CEKEYTNVIDRRFHAQPVACNHCGPTYYATYNEETYIYYETLLKLTSRLLLGGEVIAAK
                     GIGGYHLICDASNERAVARLREIKQRDTKPFAVMFRDLEHLQVYTVTEPMEERCLVSWR
                     RPIVLLRQRSRLASGINPGMHTLGCMLSYMPIHYDWFARTGIPALVMTSGNLSDLPIAI
                     TPEDAEAQLAGKVAILLHHNRPIHNRVDDSVLQVCGGQPCLIRRSRGYVPEPFFTDTNV
                     EGIMAFGAEKVNTFALGKGETILQSQYIGDLKNWETFRFYTESMEQFRHLFRFNPQRLV
                     CDLHPDYLSSQEAERISKSLSLPLLKVQHHHAHAAACMLEHGLNEPVLAIVMDGTGLGD
                     DGKVWGGEFFFCDRAKYRRLSHFEYVPLPGGDKAAEEPWRMVVAYLWHYFKDEPSGIPY
                     PADFVERIGTERIAMLERMMEKGVNTPYTSSAGRLFDAVASLLGICDVSSHQAEAPVLL
                     EQAAMGERNAYAYPVSAEGEEISFYSLFEALLHDKTNEVPVSLISARFHTTLASLFVQK
                     ARLLIKRTKATQVVISGGCFQNKLLTESMRRQFIMAGVPVYIPSRIPCNDGGIAVGQLT
                     IASVTPF"
     CDS             2655..3002
                     /locus_tag="ctg52_3"
                     /transl_table=11
                     /translation="MHELSIARSIVELVEEQADNRGASVVEELELEIGHLSGVEIQTLA
                     FALDSAIKGSKLEKARIIRHYIEGEGQCSDCETIFPMNALFSPCPHCGSYLVKILKGKE
                     LRVKSIVIKKE"
     CDS             3032..3784
                     /locus_tag="ctg52_4"
                     /transl_table=11
                     /translation="MCGTCGCGEHHHHHDHAHEHSHGHEHHHHPDEGIVINLEQDILQR
                     NNLLAERNRGYFEAKNLFCLNLMSSPGSGKTTLLEETIRRLKAKRPIYVIEGDQQTSND
                     ADRIAALEIPVFQVNTGTGCHLEADMVNHAVKHLNPKEGAILFIENVGNLVCPAMFDLG
                     ESKKVVIVSTTEGDDKPLKYPHIFQEADICVINKIDLAPYLNTKVEVLRENALKVNHHL
                     QIFEVSATKGDGMDAWCDWLQTESAKCK"
     CDS             3864..5924
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_unknown: CoA_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_unknown: Succ_CoA_lig"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_5"
                     /sec_met_domain="Succ_CoA_lig (E-value: 6.1e-37, bitscore:
                     116.4, seeds: 149, tool: rule-based-clusters)"
                     /sec_met_domain="CoA_binding_2 (E-value: 1.7e-21, bitscore:
                     66.9, seeds: 225, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINRELINPQSIVVVGGSNNVHKPGGRIVRNLLDGKYKGELCVVN
                     AKETDVQGVKSYPSVHDIPGTELAIISIPSKSCPEVMEVLARQKGVKAFIVISAGFGEE
                     THEGGILEQQMLDVVNEAGASLIGPNCIGLMNMNYHGVFTQPIPEFHPDGVDFISSSGG
                     TALFIIESALTKGLRFSSVWSVGNSKQNGVEDILEYMDRNFDPVLDSKIKMLYIEQIKQ
                     PDKLLYHASSLIRKGCKIAAIKAGSTESGKRAASSHTGAIASSDSAVEALFRKAGIVRC
                     FSREELTTVASIFTLKDVKGKNCAIVTHAGGPAVMLADALSKGRLNVPSLEGPIADELK
                     SKLYPGAAVGNPIDIIGTGTPEHLATAIDFCENRFDNVDLMMVIFGSPGLVKLYDTYEV
                     LHKKMEECKKPIFPILPSIVTAGPEVKSFVKKGHVNFSDEVTLGTALSRVINTPKPMST
                     DIQLYGVDVPEVRRIIDRLPGSGYLNPEEVRTLLRAANIPLVEEYASDDRDALLAFAKK
                     VKYPVVAKVVGPVHKSDIGGVALNIRGEEHLLFEYERMMRLPGVTGIMVQPMLKGQELF
                     LGAKYEDRFGHVVLCGLGGIFVEVLKDVSYGLAPLSYDETYSMIRSLRGYPIIKGTRGQ
                     KGIDEQQYADIIVRLSTLLRFASEIKEMDINPLVATDRGLFAVDARIRIEK"
     CDS             complement(6013..6627)
                     /locus_tag="ctg52_6"
                     /transl_table=11
                     /translation="MTIAFIRTYNNKQNSEVQEAVIREFAESQKIEIGKWAKEVGNSPR
                     ANRRLESIVKSLSPGDEILVSDISRVSRKMIEIIHIILLCIERKVTLRSVSDGYVFEDN
                     IDSKTLAFTFGLVSEIERKLVSIRTKEALALIRSKGVVLGRPKGSQQMGRLEPYKEQIE
                     KDLKDPSLTYAQIAEKYNVSLSSFKRFLKEYLPDKKKKKKK"
     CDS             6697..6879
                     /locus_tag="ctg52_7"
                     /transl_table=11
                     /translation="MKHFNSVGLKTKKPTNKFISWLFAEAGGFEPPVPLRVRQFSKLVV
                     SATHPHFLVCSVLLP"
     CDS             6993..8042
                     /locus_tag="ctg52_8"
                     /transl_table=11
                     /translation="MDLNKQILSRRPIIIALIAILVVLIGGGGFWVYRLAWAPNFKPDK
                     TVYVYIDDKKDFDDLCRQLRDSANCLRIGSFKQLSGLLKYPASMRTGRYAVKPGMSNLT
                     LLNDLRRGHQVAARVTFNNIRFKEDLAERISDQLMFGKENLLRLLNDSVYCDSLGFTPE
                     TIDALFIPNTYEIYWNISADKFIRRMKREYDAFWTPERLKKAEEIGLTPVEVSILASIV
                     EEETAASDEYPIVAGLYINRLHAGIPLQADPTVKFAVGDFSLQRILFEHLEIDSPYNTY
                     KYAGLPPGPLRIPTIKGLNSVLNHTKHKYLYMCAKEDFSGRHNFAVTLAEHNRNANRYR
                     AELNRRRIR"
     CDS             8147..9748
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_unknown: POR_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_9"
                     /sec_met_domain="POR_N (E-value: 1.5e-14, bitscore: 44.1,
                     seeds: 31, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.1e-19, bitscore:
                     57.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKHLFLGDEAIAQAAIDAGISGVYAYPGTPSTEITEYIQGSPVT
                     KERGIHCRWSANEKTAMEAALGMCYAGKRALCCMKHVGLNVAADCFMNAAMSGINGGMI
                     ILTADDPSMHSSQNEQDNRIYGNFAMIPMFEPSSQQEAYDMVYHGFELSEKLGYPILLR
                     VTTRMAHSRAGVVTSPLKPENRMNCPEDGRQRFILLPALARKRFKSLLASQEAFTEASE
                     NSAYNKYFDAPNKDLGIITTGIAFNYLSENYPDGFEHPVLKISQYPLPRKQVEKIVGEC
                     KEILVLEEGYPVVEEQLKGFLAKGVTVHGRLDGTLQRDGELTPDAVGKALGKEIQSYYA
                     IPEVVEQRPPALCQGCGHRDMYEALNEVIAEYNGTAKVFGDIGCYTLGALPPFRAIDSC
                     IDMGASITMAKGASDAGVFPAISVIGDSTFTHSGMTGLLDCVNENTNITIVISDNETTA
                     MTGGQDSAGTGRLESICAGIGVDPAHIRVMVPLKKNYEEMKAIIREEIEYKGVSVLIPR
                     RECIQTLTRKKKASKK"
     CDS             9745..10326
                     /gene_functions="biosynthetic (rule-based-clusters)
                     OD_unknown: POR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg52_10"
                     /sec_met_domain="POR (E-value: 2.4e-43, bitscore: 138.1,
                     seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTDIILSGVGGQGILSIAAVIGEAALKEGLYMKQAEVHGMSQRG
                     GDVQSNLRLSDEPIASDLIPKGHADLIISLEPMESLRYLPYLKKEGWLVTNSRPFVNIP
                     NYPEIEKVNAELDKLPHKVVLDVEEIAKEAGSVRAANIVMLGAATPFIGIEYDKIEAGI
                     RQIFGRKGEDIVNMNLKALKAGYDLAQSLR"
     CDS             10474..11049
                     /locus_tag="ctg52_11"
                     /transl_table=11
                     /translation="MRFDENFNVSLSLNPKREMIKVMKKYLLASLLALLAFVGKAQEDN
                     SDIVKVGDTMPSFTIVSDNGSKLQSASLKGKVILVNFFATWCPPCQKELAAVQQTLWPK
                     YKNNKDFVLLVIGREHSDADLQKYNEKKGFDFPLYPDKDRAIFGAFAKNLIPRGYLVGK
                     DGKIIYTSKGYTDEEFAELMTKIEGALK"
     CDS             11055..11843
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg52_12"
                     /sec_met_domain="Fer4_7 (E-value: 5.7e-11, bitscore: 32.9,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4 (E-value: 6e-11, bitscore: 31.8,
                     seeds: 528, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 1.2e-05, bitscore: 15.7,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYSNIHLIYFSPTHTSAKIVYAIAEGMGATSMSESDVTCESLDM
                     EEYIDDELTIIAAPVYGGRVAETAMERFRMFRSAHHAPVVPVVLYGNRDYEDALKELCD
                     LVSEQGFVPVAAGAFIGEHSFSRKGMPIAEGRPDESDLNQATEFGKKIIEELEKVSCVE
                     CLSALEVKGNFPYRVKGPSTPQAPVTDNDLCTQCEYCVDVCPTHAISLADEGMYSDPNL
                     CIKCCACVKECPEGARTFDTPYTAMLHKNFSARREPEIFF"
     CDS             11965..14391
                     /locus_tag="ctg52_13"
                     /transl_table=11
                     /translation="MKTYLFLLLFVFQAFSLSSQISLKGYNQEKIDPSLFEGRWKARWI
                     SYPGEAPNVYGVYHFRKSFDLEVVPSRFIVHVSADNRYKLYVNGKLVSLGPARGDIYNW
                     SFETVDLAPYLRKGKNTLASVVWNYAERKPVAQISYDQTGFILQGNTGHEAVVNTDTTW
                     VCLRNKAYAPWTEWQVLGYYVAGPGEELEASAYPWGWEQPDYDDRKWEKAVRGMEGATK
                     GSRDYPGRLLVPSPIPPMDSRIERLAKLRRSEGIECPQGFPYWPKALTIPANTEVRLLL
                     DNDYLTTGYFSLAFSKGKEAEIHIGYSEALYKQEEESTTKSYALNGKGHRDELTDKQFI
                     GYGDKILADGGDNRLFTSLWWRTWRYVELKVKTASEPLVIEDMYGTFSAYPFRNETTFS
                     APGHEELGRMLEIGWRTARLCANETYMDCPYYEQLQYFGDTRIQAMISMYNTSDPYMVK
                     NAIEQGRQSMVAEGITMSRYPSSVHQFISSYSLWWICMGHDYWMYRGDEAYMKTLLPAY
                     RQVLSWYEQWLKPDYSLSYVPHWFFVDWAAGFDYGEPIREKEGSSALQDLMYIMTLEFA
                     VEMEQAIGLPAMADHYRKIATEMRKTIRPKYWDAARNLFADTQDHRGYSQHVNALAILT
                     GVTKGEEAVKVMNQTLADTSLIQCTIYFRYYLNQALKVSGLGDQFLDNLQIWRDQMALG
                     LTTWAEMPEPSRSDCHAWGASPNIEFYRILLGIDSDAPGFRKIRIAPSLGKLKEVSGTI
                     PHPLGSVTAAYKLDERGEGTARLVLPEGTTGIFIWDGKEIPLKPGEQVISLSSRH"
     CDS             14410..16140
                     /locus_tag="ctg52_14"
                     /transl_table=11
                     /translation="MRRVYSIALLLLVALGLSATTKEVKLKLVETSDIHGNFFPYNFIE
                     QREWGGSLARVYSFVQEERRAYGDNLLLLDNGDILQGQPSAYYYNFMDTVSTHIASAMM
                     NYIGYNAGNMGNHDVEAGHAVFDRWIKQCDFPILGANIIRTSDRETYLKPYEVFERDGV
                     KIVVLGMITPAIPVWLPETLWQGLYFADMEETARKWMKIIQEKEKPDVVVGIFHAGNEA
                     RTMSGQYREDASMEVAQRIPGFDVVMMGHDHRRYCGKVANIEGDSVLLINPASNGRVVG
                     SVDVVLKMEHGKVLDKQVSGVLTDVDKLEPSEEFMEKFAPQYKAVNDFVSEKVGTFTES
                     IATRPAYFGPSAFIDFIHSLQLELTGADVSFAAPLSFDAKIDKGDITISDMFSLYKYEN
                     MLYTMNLTGAEIKGFLEESYAMWTNRMKSPDDHVLLLKERKKGQENYVSFVNFSFNFDS
                     AAGIIYTVDVTKPEGEKITILKMADNRPFDENKTYKVALNSYRGNGGGELLTKGAGIPQ
                     DELKSRIIHSTDKDLRYYMIQYIKEKGVLSPQPLNQWQMIPQDWTRPAAERDCKFLFGE
                     "
ORIGIN
        1 gttacctgtc ggcatgaaaa atatggcaga acatagaaac aggccactga aacagagaac
       61 aataggcatc tttgaccgat atacggaaaa ttatgcgtat cttcgctctc gcaaacaagg
      121 gttctttgag atggcagaag caaaatcagg gtcgattccg ttacgttttc accaccggat
      181 tgacactaaa aaagggcaac ggataggtag caaaattacc tcataacctc tcgatatccc
      241 gctttttcag taaaaggaag aacattgtca ttcaacaccg aattccttta gcctccaatc
      301 acttacttta ttccaccaaa atctgcctga atctcacgaa ttcttcctat atttgtgcta
      361 tggcgaagaa taaagtatat gcgttgatta ttcaaggctt ggttcaaggg gttggttttc
      421 gcccttttat ctaccggatc gctaaagatc tggggatgaa aggttgtgtg gagaatatga
      481 ataatggagt acgtatcttg gttgccgcta ctccggatga tcgggatttg ctgataagtc
      541 gtatacggac cgagcatcct cgtgtcgctt atatccatcg gatctcctat acatctacgg
      601 aaatggatga agatgatttt gacgatttta cgattacgcc tagccattca gaatcggatg
      661 aggtcacgca ggtctccccg gatatcgctg tttgtgcgga ttgtatgcga gaccggacta
      721 ctcaacccca tcgaatcgga tatcctttta ttaattgtac gcattgtggc cctcgcttct
      781 ctattatccg ggaccttcct tacgaccgtt cgcagacaac gatgggcggt ttccttatgt
      841 gtcccgattg tgagaaagaa tatacgaatg ttatcgatcg ccgtttccat gcccaaccgg
      901 tcgcttgcaa tcattgtggc ccgacttatt acgcgactta taacgaggag acttatatct
      961 attatgagac cttattgaaa cttacctctc gcttattgct tggtggagag gttattgcgg
     1021 ctaaaggaat cggaggctat catttgattt gtgatgcctc gaacgagaga gcggttgccc
     1081 gtctgcgaga gataaagcag cgggatacca aaccattcgc tgttatgttc cgtgatctgg
     1141 aacatctgca agtctataca gtaacggagc cgatggagga gcgatgctta gtttcttggc
     1201 gccgtccgat cgtactgctg aggcaacgga gccggttagc ttccggaatc aatccgggca
     1261 tgcatacgct aggatgtatg ttgtcttata tgccgattca ttacgattgg tttgctcgta
     1321 cagggatacc tgcgttggta atgaccagcg ggaatctaag cgatttgccg atagcgatca
     1381 ccccggagga tgcggaggcg caattagcgg gaaaggtagc gatcctcttg catcataatc
     1441 gcccgatcca taaccgggta gatgattctg tattgcaggt ctgcggagga caaccttgct
     1501 tgatccgtcg ttcccggggc tatgtgccgg aacccttttt cacggataca aatgtggagg
     1561 ggatcatggc tttcggtgcg gagaaagtga acacgttcgc tttggggaaa ggagagacga
     1621 tcctgcaaag tcaatatatt ggcgacttaa agaactggga gactttccgg ttctatacgg
     1681 aatctatgga gcagtttcgt catttgtttc gtttcaatcc ccagcgattg gtttgtgacc
     1741 tgcatccgga ttatctttcc agccaagagg cggaacgtat ctcgaaatct ctttccttac
     1801 ctttattaaa ggtacaacat catcatgctc atgccgctgc ttgtatgttg gagcatggat
     1861 tgaatgagcc ggttctcgct atcgtgatgg atgggacagg tctgggtgat gatggtaagg
     1921 tttggggagg cgagttcttc ttttgtgacc gagcgaaata ccgtcgcctt tcccattttg
     1981 agtatgtccc gttaccggga ggcgacaagg cggctgagga gccatggcga atggttgtcg
     2041 cctatttgtg gcattatttc aaggacgaac cgtcgggtat tccttatccg gccgatttcg
     2101 tggaacgcat aggcacggaa aggatcgcta tgcttgaacg aatgatggag aaaggtgtga
     2161 atacacccta tacatccagc gctggccggc tgtttgatgc ggtagcttct ttattgggaa
     2221 tttgcgatgt ctccagccac caagcggagg ctccggtctt attggagcag gcggcgatgg
     2281 gagagaggaa cgcttatgcg tatccagtct cggcggaggg agaggaaatc tctttttatt
     2341 ctttgtttga ggcattattg catgataaga cgaacgaggt cccggtgagc ttgatatccg
     2401 cccgtttcca tacgacattg gcttccttgt ttgtgcagaa agcccgcttg ttgattaaac
     2461 ggacgaaagc gacacaagtg gttatctcgg gaggatgttt ccagaataaa ttattgacgg
     2521 agtcgatgag gagacagttc atcatggctg gggtccccgt ctatattccg tctcgtatac
     2581 cttgtaacga tggggggata gccgtggggc aattaacgat cgcctcggtg actccctttt
     2641 aaaagagatc agatatgcat gagttgtcta tagcccgtag catcgtggag ctggtcgagg
     2701 aacaagcgga taaccgggga gcctcggtgg tcgaagagtt ggagttagag ataggacatt
     2761 tgtccggcgt agagatccaa accttagcgt tcgcattgga tagcgccata aaaggtagca
     2821 agctggaaaa ggcccggatt atccgtcatt atattgaggg ggaaggacag tgtagcgact
     2881 gtgagaccat tttcccaatg aacgccttgt tttccccttg tccccattgt ggctcctatt
     2941 tagttaaaat ccttaaaggg aaggaacttc gggtgaagtc gattgttatt aaaaaggaat
     3001 gatatattaa tgaaataaaa acttaaatac tatgtgcgga acttgcggat gcggagagca
     3061 tcatcaccat cacgatcatg cgcatgagca ttctcatggc catgaacatc atcaccatcc
     3121 tgatgaaggg atcgtaatca atctggaaca agatatactt caacgtaaca acttattggc
     3181 ggagcgaaac cggggatatt tcgaggctaa gaacctgttc tgcctgaact tgatgagttc
     3241 gcccggatcc ggtaagacaa ctttgctgga agagacgatc cgccgtttga aagcgaagcg
     3301 accgatctat gtgatagaag gcgatcaaca aacctcaaac gatgccgacc gtatagcggc
     3361 gttggagatt cccgtgtttc aggtaaatac cggtaccggc tgtcatttgg aagccgacat
     3421 ggtcaatcat gccgttaagc atctgaatcc gaaggaggga gcgatccttt ttatagagaa
     3481 tgtcggcaat ctggtctgtc cggccatgtt cgatctcgga gagtccaaga aagtcgttat
     3541 cgtgagtacg acggaggggg atgataaacc gttgaaatac ccacatatct ttcaggaggc
     3601 agatatctgc gtaatcaaca agattgatct ggctccttat ctgaatacaa aagtggaagt
     3661 gcttcgggaa aacgccttga aggtaaatca ccatctccag atattcgagg tatccgccac
     3721 gaaaggagac gggatggatg catggtgtga ctggttgcag acagagagtg caaagtgtaa
     3781 ataaataccc cgggttttaa tgaataaatg gagaaaaaaa ctatatttgc tcccattcat
     3841 tgaatctaac taatcaaaat gttatgatta accgagaatt gattaatcct caaagcatcg
     3901 tagtggtggg aggttccaac aacgtacata aaccgggcgg tcgtatcgtg cgaaacctgt
     3961 tggatggaaa atataaagga gaattatgtg tggtaaacgc caaggagaca gatgtgcaag
     4021 gcgtcaagtc ttatccttct gtacatgata tcccggggac ggagttggcg atcatctcga
     4081 ttccgagtaa atcgtgcccc gaggtgatgg aagtgctggc ccggcaaaag ggggtaaaag
     4141 cttttatcgt gatctcggcc ggcttcggcg aggagacaca cgagggcggt atcttggaac
     4201 aacagatgct ggatgtcgtg aatgaggcgg gagcctcctt gatcggcccg aactgtatcg
     4261 ggttgatgaa tatgaattat catggcgtgt ttacgcaacc gataccggaa ttccatcccg
     4321 atggcgtgga tttcatctct agctccggcg gtacggcctt gttcattatc gagtcggcgc
     4381 tgacaaaagg gctgcgtttc tcttctgttt ggtcggttgg gaactccaag cagaatggag
     4441 tagaggatat ccttgaatat atggatcgga actttgatcc ggtattggat tccaagatca
     4501 agatgttgta tatcgagcaa atcaagcaac cggataaatt gttgtatcat gcgtcttcct
     4561 tgatacgtaa gggatgcaag atcgccgcta tcaaggcggg aagtacggag tcgggaaagc
     4621 gagctgcctc ttcgcatacg ggcgctatcg ctagttcgga ctctgccgtg gaggctttgt
     4681 tccgtaaggc gggtatcgtg cgttgtttta gccgtgagga attgactacc gtggcgagta
     4741 tctttacctt gaaagacgtg aaagggaaga attgtgcgat cgtgacacat gccggagggc
     4801 ctgcggtaat gctggcggac gctttatcca aggggcgttt gaatgttcct agtttggaag
     4861 gccctatcgc tgatgagttg aaatccaaac tgtatccggg tgccgctgtc ggtaatccga
     4921 ttgatattat cggtacgggg acaccggaac atctggctac agccatcgat ttctgtgaga
     4981 atcgtttcga taatgtggat ttgatgatgg tcatcttcgg tagtcccggt ttggtaaaac
     5041 tttatgatac ctacgaggta cttcataaaa agatggaaga gtgcaagaag ccgatcttcc
     5101 cgatattacc gtctatcgta acggccggac cggaggtgaa gagctttgtc aagaaaggcc
     5161 atgtgaactt ctcggacgag gtgacattgg gtactgccct ttcacgggtg atcaatacgc
     5221 cgaaaccgat gagcacggat atccagctat atggcgtgga tgtaccggaa gttcgtcgta
     5281 tcatagaccg gttgccgggt agcggttatt taaatccgga ggaagtgcgt acattgttgc
     5341 gtgccgctaa tatcccgtta gtggaggaat atgcttcgga tgatagggat gcgttgctgg
     5401 cttttgccaa gaaggtgaaa tatccggtgg tagccaaggt tgtggggcct gtgcataaga
     5461 gcgatatcgg tggtgtggcc ttgaatatcc gtggagaaga gcatttattg ttcgagtatg
     5521 aacgtatgat gcgtctgccg ggtgttacgg gcatcatggt acaaccgatg ttgaaaggac
     5581 aggaattatt cttgggagct aaatatgagg atcgtttcgg ccatgtggta ctttgcgggt
     5641 tgggtggaat cttcgtggag gtattgaagg atgtgtctta tggtttggca ccgttatcat
     5701 atgatgagac ttattcaatg attcgttctt tgagagggta tccgatcatt aaaggtacgc
     5761 gtgggcaaaa gggcatcgac gagcaacaat atgcggacat tatcgttcgc ctctctacct
     5821 tattgcgttt tgccagcgag ataaaggaaa tggatataaa tccgttggtg gctacggata
     5881 gaggcttgtt cgctgtagac gcccgtatcc gtatagagaa ataataatga ttcaatgtgc
     5941 caatatgcga atatgctaat atctgaatta tccacttctg gtatttcatt ggcatattgg
     6001 cacattgaat cattatttct tcttcttctt tttcttatcg ggaagatact ctttcagaaa
     6061 gcgtttgaag ctacttagcg atacattgta tttctccgct atctgggcgt aagtcaagct
     6121 cggatctttc aagtctttct cgatttgttc cttataaggc tccaagcgtc ccatttgttg
     6181 actacctttc ggacggccca gcaccacacc tttacttctg atcaaggcaa gggcttcctt
     6241 cgtacggata gagaccagct ttcgctcgat ctcggagacc agaccgaagg taaaggccaa
     6301 agtcttactg tcgatattat cctcgaacac atatccgtcg cttacgctac gaagcgttac
     6361 ctttcgctct atacaaagca aaatgatatg gatgatctcg atcatcttac ggctcacacg
     6421 ggatatatcg gacacaagta tctcatcccc gggacttaaa gatttgacaa tactttccag
     6481 tctgcggttc gcacgaggac tatttcccac ctctttagcc cacttcccga tctctatctt
     6541 ctgagattcg gcaaattccc ggatcacagc ttcttggacc tcggagtttt gcttattatt
     6601 atatgttcgg ataaaagcaa ttgtcataat gtatatattt aattatctcc ttttaataac
     6661 agatcgactt acgataagtt caaatatgac aaatatatga aacactttaa ttcggttggc
     6721 ttaaaaacaa aaaaaccaac taataaattt attagttggc tctttgcgga agcgggggga
     6781 ttcgaacccc cggtaccctt acgagtacgt cagtttagca aactggtggt ttcagccact
     6841 cacccacact tccttgtgtg ttctgtgctt cttccttaga attgcgatgc aaaggtagaa
     6901 ctataatttt aaataaacaa ggctttgcac atcatttttt tcgaaaaaag atactacttt
     6961 tgtgccttat tctgatattc aatagattat tcatggattt gaacaaacaa attttatcga
     7021 ggcgcccgat aattatcgcc ttgatagcga ttctcgttgt tttgataggc ggtggaggct
     7081 tttgggtgta ccgtttggct tgggctccga attttaagcc ggataagacg gtctatgtct
     7141 atatagatga taaaaaggat tttgatgatc tttgccggca gttgagggat tcggcgaact
     7201 gtctccgtat cggtagcttt aagcaattga gtggattgtt gaagtatcct gcgtccatgc
     7261 gtaccggtcg atacgccgtg aagcccggca tgagtaattt aaccttattg aatgatttgc
     7321 ggagaggaca tcaagtagcg gcccgggtta cttttaataa tatccgtttc aaggaagatt
     7381 tggcggaacg tataagtgat caattgatgt tcgggaagga aaatctcctg cgtctattga
     7441 atgattctgt gtattgcgac tctttaggtt ttaccccgga aacgatcgat gccctcttca
     7501 ttcctaatac ctatgagatt tattggaata tatccgcgga taaatttata cgtcgcatga
     7561 agcgtgaata tgacgctttc tggacaccgg aacgattgaa aaaggcagag gagatcgggc
     7621 ttactccagt cgaggtatct atcttggctt ctatcgtaga agaggagacg gcggcatcgg
     7681 acgaatatcc aatcgtggcg ggcctttata tcaaccgcct tcatgctggt attcctttac
     7741 aggcagaccc taccgtaaag ttcgcggtgg gggatttttc tttgcaacgt atcttatttg
     7801 agcatttgga aatagattct ccctataata cctataaata tgcgggcctg cctcctggtc
     7861 ctctacggat tcctactatc aagggcttga atagcgtatt gaatcatacg aaacataaat
     7921 acttatacat gtgcgctaag gaggatttct cgggacggca taatttcgcc gtgacgttgg
     7981 cggagcataa ccgcaatgcc aaccggtatc gggcggagtt gaataggcgc cggatacggt
     8041 aatggatcta gtataaatca taagtctctc attctaaatt gaacattttt cattaccttt
     8101 ggcggctaaa tagtgtgaat agtcaatatt aagaaaacag atacacatgg aaaaacattt
     8161 atttttgggg gacgaggcca tagcgcaagc cgctatagac gctggaatct ccggggtata
     8221 cgcatacccg ggaacccctt ctactgaaat cacagaatat atccaaggtt ctccggtaac
     8281 gaaggaaaga ggtatccatt gtcgctggag cgcgaatgag aaaaccgcca tggaagccgc
     8341 tttgggtatg tgctatgccg gtaaacgtgc gctttgctgc atgaagcacg tgggtttgaa
     8401 tgtagccgcc gattgcttta tgaacgccgc tatgagcggt atcaacggag gtatgatcat
     8461 ccttacggcc gacgacccat ccatgcactc ttcccagaat gagcaagaca accgtattta
     8521 tggcaatttc gccatgatcc cgatgtttga gccatccagc cagcaagagg cttatgatat
     8581 ggtatatcat ggattcgagt tatccgagaa attagggtat cctatcttgc tgcgtgtaac
     8641 gacccgtatg gcgcattctc gtgccggtgt cgtaaccagc ccgttgaagc cggagaaccg
     8701 gatgaattgt ccggaagacg gtcgtcaacg ttttatctta ctcccggcat tggctcgtaa
     8761 acgtttcaag agtttgctgg cgtctcaaga ggctttcacg gaagcttccg agaattccgc
     8821 gtataataag tatttcgatg ccccgaataa agacttgggt atcatcacga cgggtatcgc
     8881 tttcaattat ctttccgaga attatccgga cggtttcgag catcccgtat tgaagatctc
     8941 ccagtatccg cttccgagaa agcaagtgga gaagatcgtt ggcgagtgta aggagatctt
     9001 ggtgttggaa gagggatatc cggtcgttga agagcaatta aaaggcttct tggcgaaagg
     9061 cgtgacggtt catggccgtc tggacggtac gcttcagcgt gacggtgagc ttacgccaga
     9121 tgcggtaggc aaagccttgg gtaaggagat ccagagctat tatgcgatcc ccgaggtggt
     9181 tgagcaacgt ccgcccgcat tgtgccaagg ttgtggacac cgggatatgt atgaggcctt
     9241 gaacgaggtg atcgccgagt ataacggtac ggctaaggtg tttggcgata tcggctgtta
     9301 taccttggga gctttgcctc ctttccgtgc gatcgattct tgtatcgata tgggcgcctc
     9361 catcacgatg gcgaagggcg cttccgacgc gggtgtattc ccggctatct ccgtgatcgg
     9421 cgattctacg tttacccatt ccggtatgac tggtttgctg gattgcgtga acgagaacac
     9481 gaatatcacc atcgttatct ccgataatga gacaacggcc atgaccgggg ggcaggattc
     9541 cgccggaaca ggacgtctgg agtctatctg cgccggtatc ggtgtggacc cggctcacat
     9601 ccgtgtgatg gttcctttga aaaagaacta tgaggagatg aaagctatca tccgcgagga
     9661 gatcgagtac aagggcgtat ccgtattgat cccccgccgt gagtgtatcc agacattaac
     9721 cagaaagaaa aaagcaagca agaaatgaaa acagatatta tactatcagg tgtaggagga
     9781 cagggtatcc tttctatcgc cgccgttatt ggagaagccg ccttaaaaga aggtctgtat
     9841 atgaagcaag cggaagtaca cggtatgagt caacgggggg gagacgtgca gtctaacctg
     9901 cgtctttccg acgagccgat cgcctcggac ttgatcccga agggccacgc cgatttgatc
     9961 atctccttgg aaccgatgga gagcttgcgt tatctgcctt acctgaagaa agagggttgg
    10021 ctggtgacaa actcccgtcc gttcgtgaac atcccgaact atccggagat cgagaaagtg
    10081 aacgccgagt tggacaagct ccctcacaag gtcgtattgg acgtggagga gatcgccaag
    10141 gaagcgggtt ctgtccgtgc cgccaatatc gtgatgttgg gggcagctac cccatttatc
    10201 gggatcgagt atgataagat cgaggcggga atccgtcaga tattcggtcg taagggcgag
    10261 gatatagtta atatgaacct aaaggcgttg aaagccggtt atgacttagc gcaaagtctg
    10321 cggtaaatct ttctccgggt ttgcatggta tcagcgtacg tgacatctcc gggtttcacg
    10381 tacgtttttt ttaacatcta accccctaga acttttagaa gagctgtcga ggggtaggta
    10441 cagcatcgta gaactttcgt aagccttaga attatgcggt ttgatgagaa ttttaatgta
    10501 tctttgtcgc tgaatcctaa acgagaaatg attaaggtta tgaagaagta tttattggct
    10561 agtttactag cgttattggc tttcgtaggc aaagctcagg aggataattc cgatatcgtg
    10621 aaggtcggtg ataccatgcc gtcatttacg attgtttccg acaacgggag taagttgcag
    10681 tccgcttcgt taaagggaaa agtgatcctc gtgaatttct tcgccacttg gtgtcctccc
    10741 tgccaaaaag aattggccgc tgtccaacaa accctctggc cgaaatacaa gaacaacaag
    10801 gacttcgttc tcttggtgat cgggcgtgag cattccgatg ccgatctaca gaaatataac
    10861 gagaaaaaag gcttcgattt tcctttgtat cccgataagg accgggctat tttcggcgct
    10921 ttcgccaaga acttgatccc tcgtggctat ttggtcggaa aagacgggaa gatcatttat
    10981 acgagcaaag gctataccga tgaggaattt gctgagttaa tgactaaaat agagggtgcg
    11041 ttaaaataag aatcatgaaa tatagtaaca tacatttaat ttatttttct ccgacacaca
    11101 cgtccgccaa gatcgtttac gcgatagcgg aaggaatggg tgccacttcg atgtccgagt
    11161 ctgatgtcac ttgtgagagt ctggatatgg aagagtatat tgatgatgag ctgacgatta
    11221 tagccgctcc tgtatacggt ggccgtgtgg cggagactgc catggaacgt tttcgcatgt
    11281 tccgttctgc ccaccatgcg ccggtagtcc ccgtggtact gtatgggaac cgggattatg
    11341 aggatgcctt gaaagagctc tgtgatttag tgtcggagca ggggttcgta cctgtggctg
    11401 ccggagcgtt tatcggcgag cattctttca gccgcaaggg gatgcccatt gccgaggggc
    11461 gtccggacga gtcggatctt aatcaggcta cggaattcgg gaaaaagatt atcgaggagc
    11521 tggagaaggt ttcctgcgtg gaatgcttgt ccgccttgga ggtgaaaggt aatttcccgt
    11581 atcgggtgaa aggcccttcc actcctcaag ctcctgttac ggataacgat ttatgtacgc
    11641 aatgtgagta ttgcgtggat gtgtgtccta cacatgcgat atccttggca gacgagggta
    11701 tgtatagcga cccgaaccta tgtatcaaat gttgcgcctg cgtgaaagag tgtcccgagg
    11761 gcgcacgtac tttcgatact ccttacacgg cgatgctcca taagaacttt agcgcacgca
    11821 gggagccgga gatattcttc taatggagga ccgggcatcc ggtatattgt gagggaaagc
    11881 gtcaaaaggc aaaagttctt ttggcgcttt ctcttttttt gtacctttgt tcggatcgtt
    11941 aatctcaaat aataccgtgt ttgtatgaaa acctatttat tccttttgct ttttgtgttt
    12001 caagcctttt ccctttcctc ccagattagc ctgaaagggt ataatcagga gaagatcgat
    12061 ccttctcttt tcgagggacg atggaaagcc cgttggatct cctacccggg tgaggccccg
    12121 aatgtatatg gggtctatca ttttcgtaaa tcgttcgatc tggaggtggt tccttcccgg
    12181 tttatcgtcc atgtttccgc cgataaccgt tataaattat atgtaaacgg gaaattggta
    12241 tccttgggcc cggcccgtgg ggatatctat aactggagtt tcgagacggt ggatctggct
    12301 ccttatctga ggaaagggaa gaatacgctg gcctccgttg tctggaatta tgccgagcgg
    12361 aaacctgttg cccagatcag ttacgatcag acgggtttta tcctgcaagg caatacgggg
    12421 catgaggcgg tggtaaatac ggataccact tgggtctgcc tgcgtaataa ggcgtatgct
    12481 ccttggaccg aatggcaggt attggggtat tacgtggctg gcccgggtga ggaactggaa
    12541 gcctccgctt atccttgggg ctgggaacaa ccggattacg acgacaggaa atgggagaag
    12601 gccgtacggg gcatggaagg tgccacgaaa ggatcgagag attacccggg acggttgctg
    12661 gttcctagcc cgatacctcc gatggacagc cggatcgagc gtctggccaa gctccgccgg
    12721 tcggaaggga tcgaatgccc gcaaggattt ccttactggc caaaagcttt gacgatcccg
    12781 gcgaatacag aggtccgctt gcttctggat aatgattact tgacgacggg ttatttctcc
    12841 ttagccttca gcaaaggaaa ggaggccgag atccatatcg gttattcgga agccctctat
    12901 aagcaagaag aggaatcgac cactaaatcg tatgcgttga atggcaaggg acatcgggac
    12961 gagttgacgg ataagcagtt tatcgggtac ggggataaga tactggctga tgggggagat
    13021 aatcgtctct tcacctccct gtggtggcgt acatggagat atgtggagtt gaaagtgaag
    13081 acggcttccg agcctttggt gatcgaggat atgtatggga ctttctctgc ctatcctttc
    13141 cgtaacgaga ccactttctc cgctccggga catgaggagc tgggccgtat gctcgagata
    13201 ggatggcgta ccgcccgtct gtgcgccaat gagacgtata tggactgccc gtattacgag
    13261 caactgcaat atttcgggga tacacgcata caggcaatga tttccatgta taatacatca
    13321 gacccttata tggtgaagaa tgccatagag caaggacggc agtccatggt ggcggaaggg
    13381 attacgatga gccgatatcc gtctagcgta catcagttta tatcctcgta ctctctctgg
    13441 tggatttgta tggggcacga ttattggatg taccgtgggg atgaggcata catgaagacc
    13501 ttgcttcccg cttaccgtca ggttttgtcg tggtacgagc aatggttgaa gccggattat
    13561 agtttgtcgt acgttcctca ttggttcttc gtggattggg cggccggttt tgattatggc
    13621 gagccgatac gggagaaaga gggaagctcg gcgctccaag atttgatgta tataatgacc
    13681 ttggagtttg cggtggagat ggaacaagcg atcggcctcc ctgccatggc ggatcattac
    13741 cggaagatcg ctaccgagat gcgtaagacg atccgcccga aatattggga cgctgcccgt
    13801 aatctattcg ccgatacgca ggatcatcgt ggctattccc agcatgtgaa cgccttggcg
    13861 atcttgactg gggttacgaa aggggaggag gccgtaaagg tgatgaacca aaccttggcg
    13921 gatacgagct tgatccagtg tacgatctat ttccgttatt acttgaatca agcgttgaaa
    13981 gtttccggtt taggggatca gttcttggat aacttacaaa tatggcggga tcagatggcg
    14041 ttgggattga ccacatgggc agagatgccg gagccatccc gttctgattg ccatgcttgg
    14101 ggagccagtc cgaatatcga gttttaccgg atcttgttgg ggatagatag cgatgctccc
    14161 ggatttagga agatacggat cgctccgtct ttgggaaaac tgaaggaggt ttccggtacg
    14221 atcccacatc cgcttggaag cgtgaccgcc gcttataaat tggatgagag aggtgaggga
    14281 accgcccgtc tggtcttgcc ggaaggtact acgggtatat ttatctggga tggaaaagaa
    14341 atcccgttga aaccgggcga acaggttatt tcgttatctt cgcgtcatta atctatctaa
    14401 aatcctgata tgagacgagt ttattcaatt gccttattgc tgctggtcgc tctcggtctg
    14461 tcggcgacaa cgaaggaagt aaagttgaaa ttagtggaaa ccagtgatat ccatggaaac
    14521 ttcttcccgt ataattttat cgagcagcgg gagtggggag gaagtctggc acgggtatat
    14581 tcgttcgtgc aagaagaacg ccgggcgtat ggcgataacc ttttgctatt ggataatggc
    14641 gatatcttgc aaggacaacc ttcggcgtat tattataatt tcatggatac ggtctctacg
    14701 catatagctt ccgccatgat gaattatatc gggtacaatg cgggaaatat gggtaaccat
    14761 gatgtagagg ctggccatgc cgttttcgat cgttggatca aacaatgtga tttcccaatc
    14821 ttgggtgcca atattatccg tacctccgac cgggagacct atttaaagcc ctatgaggta
    14881 tttgagcgtg acggtgtgaa gatcgttgta ctggggatga ttactccggc tattcctgta
    14941 tggttgccgg agactctgtg gcaaggtctt tatttcgccg atatggaaga gacggcccgt
    15001 aaatggatga agatcattca ggagaaggag aagccggatg ttgtggtagg tatctttcat
    15061 gcgggaaacg aggctcgtac catgtccggc cagtaccgtg aggatgcgtc gatggaggtt
    15121 gcccagcgca ttccgggctt cgatgtggtt atgatggggc atgatcatcg ccggtattgt
    15181 ggtaaggtgg cgaatatcga gggagattcc gtgttgctga taaatccggc aagtaatggg
    15241 cgtgtagtcg gttccgttga tgtcgtgtta aagatggagc atggaaaggt tttggataaa
    15301 caagtatcgg gtgttttgac ggatgtggat aagttggagc ctagcgagga gtttatggag
    15361 aaattcgctc cgcaatacaa agcggtgaat gattttgtct ccgagaaggt gggaactttt
    15421 acggagagta tcgcgacccg tcccgcttac tttgggccat ccgcttttat tgattttatt
    15481 cactctttac aattggagtt gactggtgcg gacgtctctt ttgccgcccc gttatccttt
    15541 gacgcaaaaa tagataaagg ggatatcacg atcagcgata tgttcagtct ttacaaatat
    15601 gagaatatgc tttatacgat gaatttgacg ggagccgaga tcaaaggttt cttggaggaa
    15661 tcatacgcta tgtggaccaa ccggatgaaa tctccggacg atcatgtctt attattgaaa
    15721 gagagaaaga aaggacagga gaattatgtc tcattcgtca acttcagttt taactttgac
    15781 tccgcagctg gtatcattta caccgtggac gtaacgaaac cagagggtga gaagattacg
    15841 atcttgaaaa tggcggataa caggcctttc gacgagaata aaacgtataa agtagctctc
    15901 aactcttacc gaggtaatgg aggaggtgag ttattgacga aaggggccgg tattccccaa
    15961 gacgagttaa agagtcgtat cattcattcg accgataaag acctccgtta ttatatgatt
    16021 caatatataa aggaaaaggg cgtacttagc ccacaacctt taaaccaatg gcaaatgatc
    16081 ccgcaggatt ggacgagacc ggcggccgaa cgggattgta agtttctttt cggggaatga
    16141 gtttccgtcc ttgaagtgtc tggtttgcga tagtatctca atgggaaacg gtggtaaagt
    16201 caatggaata gagatggttt ctcaatgact ttacggccgt gtcccattga cttttttgta
    16261 tcccgtatta gggatgttgc tgataggtta gggcgcaaag ggcgcatctt tacgtatgtt
    16321 tcta
//
