LOCUS       c00165_gnlPro..        12127 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OGOJNIIE_165.
ACCESSION   c00165_gnlPro..
VERSION     c00165_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 07:54:17
            Original ID  :: gnl|Prokka|OGOJNIIE_165
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12127
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1173
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_1"
                     /sec_met_domain="ILVD_EDD (E-value: 2.1e-130, bitscore:
                     424.7, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TPANRTRLFKKAAKMIVDNAFKYYRDGDDSVLPRSIATRQAFLNA
                     MSLDIAMGGSTNTVLHLLAVAHEAEVDFTMKDIDMLSRKTPVICKVAPSCSYHVEDVNR
                     AGGIIGIMNELVKAGLVDGSVKRADGLTLNEAIDQYCITSVNVTEEAINIYKSAPAHRF
                     NLVLGSQESYYKELDTDRAPGCIRDVEHAYVKDGGLAVLYGNIAQDGCVVKTAGVDESI
                     FRFAGPAKVFDSQDAACEGILKDQVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSRHL
                     GKECALITDGRFSGGTSGLSIGHISPEAAAGGAIGLVKDGDIIEINIPERTIHVKVTDE
                     ELAKRREAEEARGTKAFTPPFRQRTVSKALKAYAKMVASADKGGVRIVED"
     protocluster    1..12127
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:5323]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..5323
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12127
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12127
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1200..2900
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.7e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LKHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGG
                     AEEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELG
                     TIMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVD
                     KREDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             2913..3467
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_3"
                     /sec_met_domain="ALS_ss_C (E-value: 9e-19, bitscore: 56.7,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             3504..4235
                     /locus_tag="ctg165_4"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLTDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSLD
                     KYNMAICNDGKAISRAAVTWI"
     CDS             4277..5323
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg165_5"
                     /sec_met_domain="IlvN (E-value: 9.8e-49, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.2e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             5824..9102
                     /locus_tag="ctg165_6"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGTITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWI
                     DNLSLRGSYGTTGNDKLIVRESNGKAGDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDL
                     KWESNQQWNIGLDFSVFNRLSGTVEYYSRTSHDLLYYKELPLSAQVGSASGYNMNIGDL
                     RNSGIEITLNANILTTKDFRWDIDANMSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSL
                     YEFIAPQYDGVNPETGVPGWLIRDGNGGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITN
                     NFQFKGIDLSFMFYYSYGSKISDYTYKERIMNRPGVGVIQELVEDRWRQPGDADVLIPR
                     WSYNQYGATVKYADNFVFDNHYWRLRNLTLGYTLPKSLTRKALVENLRVYVTGNNLLTF
                     GPAKKRYTDPETGIMGNSYNGNAETDNGIQGSRRLYMVGIQITL"
     CDS             9121..10710
                     /locus_tag="ctg165_7"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYAIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHSQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKWAFDKYKHYGEDGGSVIQSATRPEVCLMRGAEMLLIMAEAAA
                     QKGNSGEALNLLNRLQVARNATPTTNAGGEALLEDIYVERRKELICEGQAGFYDLVRLQ
                     KRLVRIGESTTNPAGHYVWGMQYLNGYNALDPQPIGTLESNDYRFFCQIPQMEILNNDA
                     ISESDQNPWSGQ"
     CDS             11379..11483
                     /locus_tag="ctg165_8"
                     /transl_table=11
                     /translation="MNIMSVNGLWRKQTYFLFVHSRKGKHTFINITDI"
ORIGIN
        1 actcctgcca accgtacccg cctgttcaaa aaagccgcga agatgattgt tgataatgcc
       61 tttaaatatt atcgtgacgg cgatgattcc gtattgcctc gcagtattgc cacccgtcag
      121 gcctttctga atgctatgtc gctggatatt gccatggggg gatcgacgaa tacagtcctt
      181 cacctgttgg ccgtggctca tgaagcggaa gtcgatttta caatgaaaga catcgatatg
      241 ctttcacgca aaacaccggt tatctgtaaa gtggctccga gttgttctta tcatgtggaa
      301 gatgtgaacc gtgccggagg tattatcggt attatgaatg agctggtaaa agccggtctg
      361 gtggacggtt ccgtgaaacg tgcggatggt ctgactttga atgaggctat cgaccaatac
      421 tgcattacct ctgtaaatgt aacggaagaa gcaatcaata tttataaaag tgctccggcc
      481 caccgtttca atctggtgct cggatcgcag gaaagttatt ataaagaact ggataccgac
      541 cgtgcacccg gatgtatccg cgatgtggaa catgcttatg tgaaagacgg cggtctggct
      601 gttctgtatg gaaatattgc acaggacggt tgtgtggtta aaacagccgg ggtagatgaa
      661 agtatcttcc gttttgccgg ccctgccaaa gtattcgatt cgcaggatgc cgcttgcgaa
      721 ggtatcctga aagatcaagt cgtctccggc gatgtcgtcg ttatcaccta tgaaggtccg
      781 aagggtggcc ccggtatgca ggaaatgctt tatcctacct cttatattaa atcccgtcat
      841 cttggaaaag aatgtgcttt gattaccgac ggacgtttca gcggtggaac ttccggattg
      901 agtataggac atatttctcc cgaagcggct gcaggcggag cgattggctt agtgaaagac
      961 ggcgatatta tcgaaattaa tattcccgaa agaaccatac atgtaaaggt gacagacgaa
     1021 gaactggcca aacgccgtga agcggaagaa gcccgcggaa caaaagcctt tacacctcct
     1081 ttccgccaac gtacggtatc gaaagcactg aaagcatatg caaagatggt tgcttcggcc
     1141 gataagggcg gtgtacgaat agtagaagat taataaacac caaatactat attttagaga
     1201 tggacaaaca aaagataacc ggttcggaag ctttgctgaa agcgctgatc gctgaaggag
     1261 tagatactat cttcggttat ccgggtgggc aggcgatacc aatttacgat agtttatacg
     1321 attacagaga tcagttaaaa catattctgg tgcgccacga acaaggtgca acacatgctg
     1381 cacagggata tgcccgtgtt tccggaaaag tgggagtaac ggtggttact tcgggtcccg
     1441 gggcaaccaa taccatcact ggtattgccg atgcgctgat ggacagtaca ccgatggtgg
     1501 tgattgccgg ccaggttccg tctccgctgc ttggaacaga tgctttccag gaagttgatg
     1561 tgatcggtat cacacaaccg attaccaaat gggcttacca gatacgccgc ccggaagaaa
     1621 ttgcttgggc cgtttcccgt gctttctata tcgcatcgac cggtcgcccg ggacctgtgg
     1681 tactggattt ggcgaaagat gcacaggtgg gtttggtaga ttatgagtat cagaaagtgg
     1741 attatgttcg tagttaccaa cctgaaccgg atatcaggga ggaacgtatc gaggcggctg
     1801 cttcattgat aaataatgcc aaaaagccat tctgtctggt agggcagggg gttatcctgg
     1861 gaggagctga agaagaactg aaagaattct tgttgaaaaa cgatatacca gccggttcta
     1921 ccgtattggg cttgtctgca ttaccttcgg acttcccatt aaataaaggt atgttgggga
     1981 tgcatggaaa tgtcggaccg aaccgcaaga caaacgaatg tgacgtgctg attgctatcg
     2041 gtatgcgttt cgatgatcgc gtaaccggcg acctgaagac ttatgccaag caggcaaaga
     2101 ttatccacct ggatatcgac aattcggaga tcggaaagaa tgtgccggtc gacgtgaaag
     2161 tgctgggaaa tgccaagcat acgattccga tgattacggc tttactggaa gaacggaagc
     2221 gtccggaatg gaatgctgaa ttcgaaccgg atgaaaaaga ggaatataat aaggtaatag
     2281 aaaaagaact ctatcctacc gaaggccaac tgaaaatggg cgaagtagtc cgtaaggttt
     2341 ccgaagcaac cgataatgat gcgattctgg ttacggatgt aggtcagaac cagatgatgg
     2401 gtgttcgcta tttcaaatat aaacaaacac gcagcgtagt tacttcagga ggtttgggaa
     2461 cgatgggctt tggccttccc gccgccattg gagcgaagct gggagcgcct gaccgtacgg
     2521 tctgtttctt taccggcgac ggtggtatcc agatgactat ccaggagttg ggaactatca
     2581 tgcaggaaaa tctgaatgta aagatcatcg ttcttaacaa caatttcctg ggaatggtac
     2641 gccagtggca ggagctgttc ttcaacgaac ggtattcgaa taccatcatg aagaatccgg
     2701 attttgtagc gatagccaag gcttttggta ttgcttcccg tgcggtagat aaacgggaag
     2761 acttggatga ggcgattgct gaaatgttga atcacgatgg tgcctatatg ttggttgcca
     2821 atgtggaaac ttgtggtatg gtatatccga tggttccggc cggaggaagc gtgacaaaca
     2881 tgattttggg tgataagtaa ggaggagaaa ctatgaatac aaaacaatta tataccgtta
     2941 ttatcttttc ggaaaacact gttggtcttc tgaatcagat aactgttatc tttacgcgcc
     3001 ggcaactgaa cattgagacg ctttctgttt ctccctctgc tataaaggga atacataagt
     3061 ttacaattac tacctttgcc gacgaggata cgatcgacaa ggtcgtaaaa cagatcgaca
     3121 agcgtgtgga tatcctgaaa gcctattata atacggatga agacctggtt taccaggaaa
     3181 tcgctcttta taaactgagt accgaactct ttatcaagat ggggacggtt gaggatctga
     3241 tccgtaagta caatgcccgt atccttgaaa tgaatgagga ttgtgtggtg ttggaaaaga
     3301 gtggtcatta tgatgagaca caggctttgt ttaaagaatt gagtgagacg atcggtgtcc
     3361 tgcaatttat ccgttccgga cgcgttgcta taacgaagag taaggtagaa cgtctgagcg
     3421 acatgttatc tgcaatggaa aagaagttgc aggaaaaaca tgtctgagaa taataaggaa
     3481 acattttgta aataaagtaa attatggaga agaacaaagt aggagaattt catttcgtaa
     3541 cagagtctta tctgacggac ttccggggac gtattacaat ccctatgatc ggaacttatt
     3601 tgttgcatgc tgcttcttgc catgccgccg accgtggatt cggatataac gatatgaccg
     3661 aaaggcatac cgcctgggtt ctttcccgtc tggctatcga gatgacttct tatcctgcca
     3721 tgtctgaatc cgtaacttta tatacctggg tggatgaggt cggtaagttg tttaccagcc
     3781 gttgctttga actggtgaac ggcgaaggca agacctttgg ctttgcccgc tctatctggg
     3841 cggctatcga tatggaaacc cgccgcccga ccttgctcga tgtggagggc ctgagtgctt
     3901 atatcaccga ccgtccctgt ccgattgaaa aaccgggtaa aattgctccg gtggaaaaca
     3961 acacttccgg cgaaccttac cgtgtgaagt atagtgacct ggacgtaaac ggccacctga
     4021 acagtatcaa atacatggaa cacctgctcg acttgttcga tatcagtctg ttccgagaaa
     4081 aagagataag ccgtttcgaa atagcttatc agtccgaagg aaagtatggg atggagctga
     4141 ctctccataa ccaggaagta tccctcgata aatataatat ggcaatctgt aacgacggca
     4201 aagccatcag ccgcgctgcc gttacctgga tctgaaaaac aaattatttt atatacattt
     4261 taatagtaaa aagaaaatgg cagtaatgaa ttttggcggc gttgacgaaa acgtagtaac
     4321 ccgcgaagaa tttccgttgg aaaaggcaag agaagtattg aaagacgaaa caatcgctgt
     4381 aataggttac ggcgtacaag gtcctggcca gagcctgaac ctgcgcgaca acggttttaa
     4441 cgtaattgta ggacaacgta aaggtggtaa gacctgggaa aaggccgttg ctgacggttg
     4501 ggtaccgggc gaaacactgt tcgatatcga agaagcatgc gaaaaagcaa ctatcatcca
     4561 gtatctgctt tcagatgctg ctcagattga agtttggccg cgcatcaaaa aatacctgac
     4621 tccgggtaag gctttgtatt tctctcacgg attcggtatc acttacaaag aacgtacaaa
     4681 catcatccct cctgctgatg tagacgtaat cctggttgct ccgaaaggtt caggtacttc
     4741 actgcgccgt atgttcttgc agggtcgtgg tctgaactca agctacgcaa tcttccagga
     4801 tgcaacaggc aaagcatggg atcgcgtgat tgcactgggt atcggtgttg gttctggtta
     4861 cttgtttgaa acaacattca agaaagaagt ttattctgac ctgaccggcg aacgtggtac
     4921 tttgatggga gctatccagg gattactgtt ggctcagtac gaaactttgc gtgaaaacgg
     4981 tcacgaacct tctgaagcat tcaatgaaac agtagaagaa ctgactcagt cattgatgcc
     5041 gttgttcgca gaaaacggta tggactggat gtatgcaaac tgttcaacaa ctgcacagcg
     5101 tggtgctttg gactggatgg gcccgttcca cgatgctaca aaaccggtgt tccagaagtt
     5161 gtatagcgaa gttgcctgcg gtaacgaagc acagcgttct atcgacacaa acagcaagcc
     5221 tgactatcgt gaaggtctgg aaaaagaact ggctgctctt cgcgaaagtg aaatgtggcg
     5281 tgcaggtgct gttgttcgta aacttcgtcc tgaaaacaac taataaatgg tgatacatta
     5341 atagttaaac attttgtgat ataaaaacgg caatccggct tttcgggttg ccgtttttta
     5401 tggtttatgt aatgcgttaa tggttaaaaa atgtttttga ttgcaactgt tattgatttt
     5461 tcatcccaat atgtatgtca ttgtttgaat gtggatttta gataaaaaaa tcaattaaat
     5521 ggtggttaaa atatatttat tagagcaata aatatacata attatgcttg tattaaataa
     5581 tgataagtta tatttgctga tggagatact gtagtttgta gagtggaaat atagaaggat
     5641 gttgtgtgta atgatcagta tatctttgtt ttagttaact ttattttatt gaaatgtatg
     5701 ccagtcactt ttatcttaga aaagtgtaac ctctaatgaa atgaacgcta ttgtgattaa
     5761 ttttatttaa ttaaagactt gaatttagct atgtggacca actcaaaact aattagatca
     5821 ctaatgattt ctgtattatt aggtgcggca ggtgcgattg ctgccaatcc tacaggtccg
     5881 gaaacgatgg tagtacaaca gggtaataag gtaaccggcc tggtagagga ccagatggga
     5941 cctgtcgccg gagcttctgt tgtagtgaaa ggaaccacta tcggtacgat aaccgatatc
     6001 gatggaaagt ttacgctgga taatgttcgg cggggagcgg ttattgttat ttcctttgtc
     6061 ggcctggcca ctcaggagat cacttggaac ggacaatcta ttttaaatgt aaaattaagt
     6121 gatgcgacac aggacctgga tgaagtcgtt gtcgtagcct atggaacggc taagaaatca
     6181 accttcaccg gatcggcctc cgttgtaaaa gctgaaaaac tcgaaaagat catgggctcc
     6241 ggctttgcgg aagcattgca ggggatgagt gccggtgtga atgttgtgaa tgtacagggt
     6301 aaccccggag ctgatgcccg tgtggagatc cgtggtattg cttccatgtc cggaaaggcc
     6361 gatccgttat atattgtgga cgggatgcct tacgatggaa aactgaatca gatcaatcct
     6421 acggacatag aatcgatgac ggtgctgaag gatgcggcgg ccacttcgct ctacggttcg
     6481 cgtgcagcaa acggcgtcgt aatgattaca accaagcggg gtaaatcaga aaaaccgcgt
     6541 attaacttcc gcggaggttg gggtacttcg gataatgctg tcaagaatcc gaaaaaagcc
     6601 gatccgtacc agcagctgga aaatacctgg tatgccttgt attatgatgc ccttctttat
     6661 gacggcatga atatgcaaca ggcgggcgat tatgcttcgt cgcaggcatt gaccaaacag
     6721 gtaaaggcta caaaagattc gaatggtaat ctgatttatg tcactccgtt cagacatatc
     6781 aatgaaaatt acgtattgca tgacggcaat gggaatcctt acatgaatcc taatctggaa
     6841 tatgtctggg atgaagatga ttgggatgtc tacaaagcta tcttctcccg taaactgcgc
     6901 caggattata gtgtggatat aagtggtcag gccaatggtg gaaaaacagc ctatttcttc
     6961 tccggcggtt atctggacga ccagggatat ggtaaccggc agtattataa acgttattct
     7021 ttccgtacca acctgagtac agagttgttc gattggtgga aagtggccgg tagcctttct
     7081 tattcgcgtc atcgccagaa cctttccggt ggtgccagcc gtgcggctaa ctttacgacg
     7141 actttgtctt caccctggtt acgtaatgaa gataataccg gttgggtcgt ttctgaaaaa
     7201 acaggggaac ggatgtacag ttacggtaaa tataccaata acttctttgg tgcccatatc
     7261 ctgaataact cgggtgatta ttgggataat ccgaacgatg acagtttcga taacaatatg
     7321 gggcatatcc tgtctgctca ggtaaataca gagtttactc ttcctttcaa cctgaaattc
     7381 cgttcggctt tgaatattga cgattactgg tatcgtacca tgcaatatac ttccgccgta
     7441 catggcagcg gacagactgc accttatggt atttctatac tggcagacgg tggttatgcc
     7501 agccgttata atttcaataa acgttccacc acctggaata atgtattgtc tggtgaatgg
     7561 atgattggtg accatacgat ttcaggtctg gtcggacatg agtggtatac ctgggactcc
     7621 cactacgaac aaggttgggg tgaaggtatc atggaactgg gtaaatatga attatcgaat
     7681 accaccaaga acttcggtgt ttccggcgga cgtgataaat actctctgct ttcgttcttt
     7741 ggtaaggtcg attataactt cttgaataag tattacttgt ccgcttcact tcgtgaggat
     7801 ggttcttccc gtttcagctc cgatcatcgc tggggtacat tctggtcgac aggcggttca
     7861 tggcgaatat cgaaagaagg ttttatggaa gacctgaaat ggattgataa cctttcgttg
     7921 cgtggtagtt acggtacgac tggtaatgat aagctgatcg tgcgtgaatc gaatggtaag
     7981 gcaggggatg aagtccttta cggataccag ggtacttatg aaagtgatga cctgtatctg
     8041 aaatccggtt taaaaccatc tacctatccg acaccggact tgaagtggga aagtaatcag
     8101 caatggaata tcggtttaga tttttccgta ttcaaccgac ttagcggtac agtggaatat
     8161 tattcccgta cttcccatga cttgttgtat tataaggaac tgcctctctc tgcccaggtt
     8221 ggtagtgcat ccgggtataa tatgaatatc ggtgacctgc gtaatagcgg gattgaaatc
     8281 acattgaatg cgaatatcct tacaacgaaa gatttcagat gggatatcga tgccaacatg
     8341 agtacgctga aaaatgaggt gacttatttg cctacaggtc cttacactta ttctggtacc
     8401 gcctgtacct acaagatgga ggaaggcaag tctctgtatg aatttatcgc tccccagtac
     8461 gacggtgtta atccggaaac cggagtaccc ggctggttga tccgcgatgg taacggcggt
     8521 tggaaacgta cggaaaagca ggaagaagta acgacagacg attttgtgta ctgtggctcc
     8581 gcgattccca aagtgttcgg tgctatcacc aataacttcc agttcaaagg gatcgacctg
     8641 tcgttcatgt tctattattc ttatggttcc aaaatatcgg actatacata taaagaacgt
     8701 atcatgaacc gtccgggtgt cggtgtgata caggagttgg ttgaggacag atggcgtcag
     8761 ccgggcgatg cggatgtgct tatcccacgt tggtcgtaca accagtatgg cgcgacggta
     8821 aaatatgcag ataacttcgt attcgacaac cactactggc gtctgagaaa cctgacatta
     8881 ggctatacgc tgcctaagag ccttacccgc aaggccctgg tagaaaacct gcgtgtttat
     8941 gtaaccggta ataacctgtt gactttcggt cctgccaaaa aacgctacac agaccccgaa
     9001 acaggtataa tgggtaacag ttataacggt aatgctgaaa ccgataacgg tattcagggt
     9061 tcgagaagac tgtatatggt cggtattcaa atcacattgt aaacgtaaaa aatgatattt
     9121 atgaaacgat ttataaatat atccttcctg tccctggttt ttgctggtat ggccctgacc
     9181 ggatgtaacg acgacctgac aaccagctcc tacgtgaaag taaacgatga agatgtactg
     9241 gggaatgtct cccagttgga aaaagtattg acttcagcct ataagcagct gtattttaat
     9301 actgataaag gagaccgtgt gtatgccggt cttcccggat tccagatgta tgtcgatgcg
     9361 agtggtgccg acgtgatcag ccataccaat atgggaggtg atcaggtaac agcataccag
     9421 tattccaact caaaaacaca ggctgacgga aatgcctcaa aaatctggtc gatgtgctat
     9481 aatgtgatca accgtgccaa tatcatcctg accaatgtgg atgccgccgc cggtgatgaa
     9541 acacagaaaa aacatatcaa aggccaggcg ttggcgatgc gtggaatcca gtatttccat
     9601 ctgatccaga attaccagca gacgtatgcg atagctaaaa gcaagcgtgg ggtgatcctg
     9661 cgtacctctt ccgatgatga atcccataaa ggtttttcta ctgtagagga agtctatacc
     9721 cagattgtgt ccgacctgac gacggctaaa acattgcttg ccgattataa tccggacgat
     9781 atgtggctga tcaactccaa aatatgttcg ggaatcctgg cccgtgttta tctggtgatg
     9841 cagaactggg acggcgctta caatgaagcc aagatcgtct acgaccagca cagccagttg
     9901 atgacccgcg aacaataccg ttccggtttc gacgatatga tctccggcaa ttatgcggaa
     9961 gtggtatggg ccatgaaata taccgccgat aataacctgg gcggtagtac gcagttcaat
    10021 ttctggtata accaggatgc cagctacggc gagggttatg ccgatggtcc tatctactcg
    10081 ttccttgact acttcgtgga tgagcagttt gtgaaactat ttgaagaaaa agaagaccgt
    10141 taccagttct ggaaacgtac gaacaatgcg aatacggaaa tcaatacaaa atgggctttc
    10201 gacaaataca agcattatgg tgaagacggc ggaagcgtta ttcaaagcgc cacccgtccg
    10261 gaagtctgcc tgatgcgcgg agccgaaatg ctgctgatta tggcggaggc tgctgcccaa
    10321 aagggtaact ccggcgaggc tctgaatctg ctgaaccgtt tgcaggtggc gcgtaatgct
    10381 accccgacaa ccaatgccgg aggcgaagct ttgctggaag acatctatgt ggaacgccgt
    10441 aaagagttga tctgtgaagg acaagccggt ttttatgacc tggtgcgcct gcaaaagaga
    10501 ttggttcgta tcggtgaatc aactaccaat cctgccggac attacgtatg gggcatgcag
    10561 tatctgaacg gatataatgc gctcgatccg caaccgatag ggacgctgga gtcgaacgat
    10621 taccgtttct tctgccaaat cccgcaaatg gaaatcctga ataatgatgc gatctccgaa
    10681 tcagatcaga atccgtggag cgggcagtaa gtttcatctg ttgtaaataa ataaaagaga
    10741 gggaggtgtt tattacatgc ctccctctct tttatttgta acatttgatg ttcactgttt
    10801 tactttttgt cctttagcac ttcctgtaac atggccacct tctcctgctc cgctttcaat
    10861 aaacgttcgt ataattcaac gactttttct aaggggttaa atgtaggatt ataattctgg
    10921 caattagcat tatcttgcca ggtgccggaa aagatattaa tggaagtggc ttcgcctagt
    10981 tccgtaattg cttcttcggg tatatctaat gctttggcaa tcttttcgat tacttccggc
    11041 tccagattac ttcttttttc gtatgtcgaa agggttagta gaaaataaat ccggtttatc
    11101 tctcataata aatatcggaa agagttgcct gataatattt gtaccacaga aaaaacacat
    11161 caaaggtcag gcgctggcga tgcgtggaat ccagtatttt cacctgatcc agaattacca
    11221 gtaaacgtat gtcattgcga aaaatagttt ctctttcaac cgataatagt ggacatgata
    11281 tcagtgaaac ggttgatgca aatcagtgtc gtatggaaac ttcacttcct gtaaccaaac
    11341 agacggcaaa atcaaaatga tataaaaatg aatgatatat gaatattatg agtgtaaatg
    11401 gcctttggag gaaacagact tattttttat ttgttcattc tagaaaaggg aagcatacat
    11461 ttattaacat aacagatatc tgatatcgac tttttatctc gtttaaaccg aagaaaattt
    11521 tagtttaaac agatttcaat ttcgtttaaa ctgagataaa tttctattgt agtggagttt
    11581 ttattcgttt agagaagaaa aacacctcaa ttagtgnnnn nnnnnncttt taaaaaagaa
    11641 aatcatatgt ttttagacag tttttatttc cagagcaacc gctttttgat gtgtgtgtaa
    11701 aatagcaata tgttaataaa ttatgaatag atgtggtata tgggtaacaa tcatagataa
    11761 tatacatttt ttgtgatatg aatattgcaa caatcaggtc aaagcgaaca aaggtaagtc
    11821 ggcgagattt ctataaaaac agatcgacat ttccctttgc ccgtacaatt ccttcagcac
    11881 atacataaaa tatcattttg acaatccttt aacttccagg aactctcctg acgctttgta
    11941 tccaatagta tgttctccgg ataggacttg gcttttatat cccaaaaagt aaatcatcaa
    12001 tagtaaacaa ggcaaccgca gcaaaaggat gtttcaatat agaaatattt gaactatccc
    12061 gttcccgtgc tcgacacggg atcgcaaaag cacaaaccgt atcctatatg tatcttttga
    12121 tactgcc
//
