LOCUS       c00016_gnlPro..        13701 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LJKEAIOP_16.
ACCESSION   c00016_gnlPro..
VERSION     c00016_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 06:17:34
            Original ID  :: gnl|Prokka|LJKEAIOP_16
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 42314
            Orig. end    :: 56015
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13701
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[52314:55804]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13490
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13701
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13701
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(468..1058)
                     /locus_tag="ctg16_46"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPILVQRIFQSDQQNEAKAAAE"
     CDS             1298..2908
                     /locus_tag="ctg16_47"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             2972..3490
                     /locus_tag="ctg16_48"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             3619..4365
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg16_49"
                     /sec_met_domain="adh_short_C2 (E-value: 2.2e-75, bitscore:
                     245.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSCGG
                     AAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLRMK
                     EEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKAGL
                     IGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDIAA
                     LTAFLASDDARYITGQVIACDGGMTM"
     CDS             4389..5594
                     /locus_tag="ctg16_50"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATKDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPVA
                     GASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             5608..5808
                     /locus_tag="ctg16_51"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             5920..6054
                     /locus_tag="ctg16_52"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGRYVKAAVYHMDEKRAAEFDGIFR"
     CDS             complement(6272..7012)
                     /locus_tag="ctg16_53"
                     /transl_table=11
                     /translation="MKKTLTFLIAMGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGL
                     GSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNT
                     GTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAP
                     TANTEGDTVTISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRRRA"
     CDS             7307..8014
                     /locus_tag="ctg16_54"
                     /transl_table=11
                     /translation="MKKLLSTLILSAGMSLSATANTTLLDSSIVGYSDFTSQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGTNNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLTESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             8269..8676
                     /locus_tag="ctg16_55"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSPKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLDLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8710..9525)
                     /locus_tag="ctg16_56"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(9528..9800)
                     /locus_tag="ctg16_57"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_58"
                     /sec_met_domain="SucD_FumR (E-value: 2.5e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             10724..12682
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_59"
                     /sec_met_domain="FAD_binding_2 (E-value: 4e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             12723..13490
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg16_60"
                     /sec_met_domain="Fer2_3 (E-value: 2.1e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 7.2e-11, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.1e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
ORIGIN
        1 tctgtaatgc cgtgacatgg aacaagaaaa tctcttgatt tctacttgcc accatttaca
       61 ttggtgccag caaacctccg tggatgcgga ggttccagta gttaacaaac actgtattta
      121 attcgaatta tgaagaacat cgctatcctc gccatcgccg gcgccgcttg cctggtcgct
      181 tcctgctccc agcagcagca gcaacagcaa accaccgctc ctgctcccgc tccggttgtg
      241 caggccaagg gcaagtaagt ttgcagcggg gttttgccct gcaacactag caaattatcc
      301 aattaatccg cactcggtgt acgcactgag tgcgttttta tttgccctga gtccggattc
      361 cctccgccat ttgccgattc gccgggattt tccttaaaaa cggaggatac cgcaaaccgc
      421 cgcggcgcag caccgtgtgc cggttcctgc cggatcaggc ttccccttta ttcagcggcc
      481 gccttcgcct cattctgctg atcggactgg aatatccgct gaaccagaat ggggcgtttc
      541 ctggcccacc cgggccagac caggtgatgt tccatgccgt aggaatggcc ctccggaaag
      601 gccttggaaa caaatggttc ccgccagtcc tcctcccatt tgccgccttc ccggtccttc
      661 tgggtcagcg tcaccagatg cccgcagttc ttccaggcat ccagaacaat ggagccctgc
      721 aatcccttcc ccgcggcatt gacatacacg caactgtgct ccctgcccgt tcctcggtct
      781 cgaatcgtca gccctatgcg gaaatacttc acggggcggc ggcgcaggtc ccggtacaaa
      841 tcctgctgga cctgccagca caaccccctg tcgcgcaggt tggaattgac cagaatattg
      901 ttcagccagc caaacagcac agtcctgttg tcccgggcaa tcgcggcgga ctggaccacg
      961 gccgtgtccg ccagccacct ggcctccgct ccggcagcgg gaagagaggc ctgatccggc
     1021 ggcagcagcg ccaggaaggc attagccagc ccggacattt gctgctgcac gtaagtttgt
     1081 tgtatataat cctccgccgg aggagtacag caggaactcc atccgcacaa aagggcggca
     1141 gcaagcaaaa gcctgaatgt ctgcgtggtc ggcatggcgc gccaaggcta gcagactacg
     1201 cgtaaaaatc cagtaaagct ttcaaaaatg cctgcctccg ccctgacggc tcttgccttc
     1261 ccctttccat cccggtagaa tacatcctct cttcaccatg ctgacgatca aaaatctcac
     1321 aaaatcccac gccggacgga ccttgttcag ggaaacggaa atgaccatta actgggggga
     1381 acgggtggct ctggttggcc ccaacggagc aggcaaatcc accctgttcc gcatgattct
     1441 gggagaagac acgccggacg aaggctccat cagcatggat gaatacgcca tcgtgggcta
     1501 tcttccccag gaagccagcg aaccgaagga tgaaaccgtt ctggaaatcg ccctgggcat
     1561 cacgccggaa atggaacagg ccatccacac catccggacg gcggaaaacg ccaacaaaac
     1621 ggatacgccg gaatacgcgg aagccattga cactttcaac gccgccaacg gttaccagct
     1681 ggagcccaaa gccaagaaaa ttctcaaagg gctggccttt cgggaaagcg acttccatcg
     1741 ccccgcccgg gaaatgtccg gcggctggat catgcgcgcg tacctggcca agctccttgt
     1801 cctggagccg gacctcctga tgctggacga acctaccaac cacctggacc tcctgtccct
     1861 gctgtggctc cagcgatacc tgaaaaacta ccccggagcc atcctgatga tttcccacga
     1921 ccgggatttc atggatgagc tggtggaaag cgtgtacgac atcgacaacg aagaactggt
     1981 ggaataccgc ggcaattact cggacttcct ccaacaaaag gacgtgcgct tcgagcagct
     2041 tcaggcggcc taccgcaacc agcagaagga aatagcgcac attcaggaat ttattgaccg
     2101 tttccgctcc atcaattcca aagccgggca agtccagagc cgcatcaagc agctggaaaa
     2161 gatgaaaatc attcaaaaac cggtagcccg caggaaagta tttaaattca acttccccca
     2221 gcctccgcgc agcacccaga aagtcattga gctggaaaaa gtctgccaat cctatggcga
     2281 ccgcagggtt tatgaaaacc tggacctgct ggtggaacgc ggggagcgca ctgttcttgt
     2341 aggcccgaac ggcgcgggca aatccactct tctcaaaatc ctggcgggca tcatccccat
     2401 tgactccgga caacgcactc ccggtaccac gacgcgcatc ggctacttct cccaggcgcg
     2461 aacggaaaac ctgaatccgg aaaataccgt gctggaggaa atcatgaaat gcagcgctga
     2521 aatccgggag gaagaagcgc gttccatcct gggttccttc ctgttccgga ggctggatgt
     2581 ggaaaaacgc gtcagcgttc tttccggcgg ggaaaaatcg cggctcagcc tggtcaaatt
     2641 cctggtggat ccgcccaacc tcctgctgat ggacgagccg accacccacc tggacctttt
     2701 gtccgtagaa gccctggtgc aggctctgaa gcattatgaa ggaacactgg tcttcatctc
     2761 ccacgatgtg cacttcatcc gttccctggc acaaaaaacc ctgcatgtga accgggggac
     2821 catcaccgcc tacgcaggtg gatatgacta ctatctggaa aagtcaggca ttctggacga
     2881 tgaaaaaggc ggcatcacgg cggaataagg ctcttttttc agtttcccct ttttccttgc
     2941 cgtggatttc atcctgcctt aaaagaacag gatgaaggct tttcttgttc ctctcttata
     3001 ttctgcgctt ctgtccggag cctctcttgc atttggtgaa acggccgccg gaacggcttc
     3061 ccccgcagca gcggctccgg cggaaaaaat tccttccgcg gaatccctga tcaaccaggc
     3121 cttttccttt gccatcaata tccagcagac gttggcaggc gttcaggaca aggaaagcgc
     3181 ggacaacgcc gtcaaaacgc tgcaggacat tcagaaggac atccggcatt tcctccagct
     3241 tcaggataaa ttgaacgatg cggaaaagga gaaagaagac gccttgatag aaaaaatgga
     3301 aaaacgaatg gaaatgctgg acaaccgctg caggcaggaa ggcaaacgcc tgtttgaggc
     3361 ccgctattac ggttccgccg ccttaaagga cattttggaa aattcggatg aattcagcga
     3421 cctggtagaa ccggatgaag acggggcgcc ccccggtgca ctccgggaaa atgaagaggc
     3481 cggacagtag ccccccgccc cgtttctccc cccctctttt ttcattcccg gcacgcccct
     3541 tccccgtatg ggttcctgcg cggccaagtc catttcaagc ttgccggaac cgtgaaaaac
     3601 gggtttactg tgggcagcat gcaaaagtta gcaggtaaaa cagccatcgt taccggcgcg
     3661 ggccgcggaa tcggcaatgc cgtcgcgcgc cgcttcgctt cggaaggagc cagggtcatc
     3721 ctgatcagcc gcagtccatc cagctgcggg ggggccgcag aagaaatcaa caaggaattt
     3781 ccggattcct gcaaggccta cccctgcgac gtagcggatt acgcggccgt tcaggaaacc
     3841 atggccgcca ttttgaaaga cttcccgcag attgacatcc tggtgaacaa cgccggcatc
     3901 acgcgggact ccctgatgct ccgcatgaaa gaggaagact gggatgccgt tctggacacc
     3961 aacctgaaaa gcgcgttcaa tacggtcaag gccctccagc gtgttctcat gaaatccccg
     4021 gccgggcgca tcatcaacat gagctccgtc atcggtctcg tcggcaacat cggtcaggcc
     4081 aattacgccg cttccaaggc gggcctcatc ggtttcacca aatcactggc tcaggaattc
     4141 gctccgcgca aagtcacgtg caacgccatt gctcccggct tcatctccac ggaaatgtcc
     4201 aatgccattc ccgacaatct caaggaagaa atcgttaaga aaataccttt gaaagaacaa
     4261 ggttccgtgg aagatatcgc cgccctgacg gccttccttg cctctgacga tgcccgttac
     4321 atcaccgggc aggtcattgc ctgcgacgga ggcatgacga tgtagggcat tccggttttc
     4381 tccattccat gcgcggcatt ttccttgttt cctgctttct gggaggaagc gccctgctgg
     4441 ccgggtgccg ggaagaaaat aattcccccc gcccggccac gaaagatgcc gcgcgcatta
     4501 ccagcgcacg ccagtgggga gaaagccgat ccgcgctgca aaaacgggaa ctggaccgcg
     4561 ctgccggtcc tgcccttccc attccggatg acctgccgtc ccgggagctg gtcggcacaa
     4621 cgcgccaaat ccatcagctc attgaagctt ccggaaatcc ggcacgtttt gaatcctaca
     4681 cggaaacggt tcccgtggcg ggagcttccc tgcgcatggt cgccataccg ggaggaacgt
     4741 tcctcatggg gagtcccgcg gaagagccgc accggaaacc ggacgaaggt ccgcagcata
     4801 aagtgagcat ctcccccttc tggatctcgg aaacggaaat cccctgggaa ctttatacgg
     4861 ccttcatgga aaacgggcgt ccgcgcgcca aggacggcca gcttctggag gaacagccgg
     4921 atgacgaact gtgggactcc gttacgcagc ctaccgcccc ctacaccgcc atgaacctgg
     4981 gcatgggcca cggctatgaa cacggtctgc ccgccatctc catgtcccac cacgccgcca
     5041 gcaaattctg cgaatggctg agcgcccaga ccgggcatta ctaccgcctg cccacggagg
     5101 cggaatggga atacgcctgc cgggccggct cccccggcgc ctattcttac ggaaacgggg
     5161 aagcctctct ggaccagtac gcctggtact ggaacaactc caatgaccgc taccagaaaa
     5221 caggctctaa aaaaccaaat aagtggggac tccgggacat gcacggaaat gtggcggaat
     5281 gggttttgga ctcttacgtt ccggatgcct acggcaaacg gagcggcttg cccgcgaaag
     5341 accccttggt catcatcccc ggcgcccctc acatcgttcg cggcggttcg tgggaagacg
     5401 acccggacag cctgagaagc gctgcgcgcc gcgccagcac ccccgcctgg aaccgtcagg
     5461 atcctcaaaa ccctaaaagc atctggtacc tgacggacgg aggcatgatc gggttccgcg
     5521 tggtgcgccc catgaacatt ccggacatta tgacgatgca ccgcctctgg aatttctcca
     5581 agggggagcc gtaaagaaca acctttcatg accattgcat taagaacgga acaatcctca
     5641 gaccatgccg aaacggaaca tgtcacgaga gaagcgttct ggaactattt cgtccccggc
     5701 tgccatgaac attacctgct ccatatcatg cgcgtcagtc cgtccttcat cccggagctg
     5761 gatgcagtcg ccgtccacgg cagccgcatc gtcgggaaac atcgttgatg caacgtccgt
     5821 catcagggca gacgatggaa aagaatatga agtgctgggc atggggccca ttgccgttct
     5881 tccgaaatac cagcgccggg gaataggacg gcgaataata tgtatgcggc ggccctccag
     5941 gtctgtgagc tgcaaagggg ttccctatcc ggcctgaaag gccgctatgt gaaagctgcc
     6001 gtgtaccata tggacgaaaa gcgcgctgcc gaatttgacg gcattttccg gtaaagaaaa
     6061 agctttccgg tactgcgtct caaaaacgtt tccagcaaat tgccgccatg ccgaaaaaac
     6121 cggatacggc ctcctgcccc cggaaattcc gtaccttccg gagggcatga atcccgcata
     6181 cggataagca attcttcctc tctggatata aaaaacaaga gctgttccgc aagaacagct
     6241 ctcatccgcc gatttttcgc catcaggaag ctcaagccct gcggcggcgc atcatcagcg
     6301 cggccagtcc cagcaggccc agggaaaccg tggctggttc cggcaccatt tcccctcgga
     6361 tttccgtgaa aatcggggat aataagctga aagtattggt tccgttggct cccgtaataa
     6421 cgacagaatc accaggcgct ccctcggcgt cataatggcc gcggatgccg ggagcagtca
     6481 atccgccgct gatcgttacg gtatctcctt ccgtgttagc agtaggggcg gctgttcccc
     6541 ccgcagcata taaatacgtt ttagacgtat cctgcatcaa gtccatcacg gactggctca
     6601 cggccaggaa acggtatgtc aatgccgcgt caagaagcag gggagaacca tccagggaag
     6661 aaaaactgaa cgtcagatta atccctgctg cagtagttcc cgtattggtg ctccagccga
     6721 tgaccgaatt gtcggagcca ttcagcacca ggaagccgta agtgacatta gcgcccaaat
     6781 tgttggcggc tccgcgcagc gtaaaactgt ccagtctgat ctctccggac agggaggagg
     6841 gagaagagga atcggaagga gccagggaag aagaccccag gccaagataa aacccatgga
     6901 tggtactatt gtaattatcc gtaccgggag tgtaataatt aaaaacggtc gctgcctccg
     6961 aggaaacagc aaagcttccc atcgcgatta aaaatgtcag tgttttcttc atatttatta
     7021 ttccttttgg atggcaactt gtagcgaatt tggaatccgc aagcaattaa aaatattaag
     7081 ggttagtata ttgtatttat aattcattga aaataatgat tttttaatat ctctggttct
     7141 tttgtcaaga tgacggggca atctttgtta ttcattggtt tcatgattga tttggcctct
     7201 ttttcattac ttgacggatt ccaaatccga ttggggaatt ccaaattcgt tattcaagcg
     7261 caagtgcata cattgaatct tgcatcattt tattaagata ctgaccatga agaaattatt
     7321 atccaccctg attctttcgg ccggcatgag cctgagcgcc accgcgaata ccactctgct
     7381 ggatagctct atcgtgggat attcggactt tacctcccaa acggcggatt tcggcaccct
     7441 gaaagattcc gtttccatca cgtctgacga cagcaatctg acgttatccg ggataacctt
     7501 caacggatac ggtaccaaca accgcgacgt tatgtctgtg acgatggttc ttgatctgtc
     7561 caaaatcaac actccggaga cctataccgc tctgtttaac gccaaaaaca gcagtgtaag
     7621 ctggggcgtg ggcctgaaca cggaccggaa actccaggga ttatggaaca acacctcata
     7681 cagcgggccc gtcgttgaca ccccgctggg cacggaaggg tccctgacca tttccgtagt
     7741 caccggagat cttggcaccc gcatctattt tggcgacagc gctacgtact attccaacag
     7801 cggcctgaaa ttcggcaacc agcaaattga tcagattctc atggacgcag gactgactga
     7861 atccatcgaa cagctctaca tccacgactc cctcctttcc caggaacaag ttggtcaact
     7921 gatgagtgaa atcgccagca ttccggaacc cgccacggct tccctgggcc tgctgggact
     7981 ggccgcgctg atgatgcgcc gccgcagggc ataagcctgt accgtccgcc tccctatatt
     8041 caaaggccgg ctcacaaaat cgtgagccgg ccttttcctt atccgttcaa acatctgccg
     8101 aaaaaacaga ggggaaaagc ttccatttgc tgcggcaacc tcacggccag cacttgacgg
     8161 aaaaatggca ttcagtctcc cccggtaggg tcatttcaag agcttccggc cccgccccac
     8221 ttccgtacac gccccttttt cccatgccgg gacagccgga accggagcat gcaaagcccg
     8281 gcttccctca gcatccggaa cagcccatcc tttcagcaat ccatttcccc gcacggtccg
     8341 gatcgctgcg gttccgtccg tcggcaacag actccttccc cgaaacaggg aaaaggagtg
     8401 ggaaaatggc tgagcttgaa cctttatccc ccgttcccgt ccatgaacct tcaaaaacag
     8461 cagctgctac tgcgcctgtt ccggtatttc aaaagcagaa aaggagaacc gcgttttttc
     8521 aacaaacgga atatatgcct tctggccgcc gccggcgcct acatcctgac tcccgacgaa
     8581 ttcctgtttg acggaatcgg caggctggac cttctggatg acgcggcggt catcctgggc
     8641 gccgtcctca ccgtcttttt cccggacggg gactagaggg ccgtatcctc cgccgcgcct
     8701 cgggcggaat tagcgggacg acactttccg gaacttcggg gactgtccca tgaatgtctc
     8761 cggattttcc aggagaagac gttccgtttc ctgccgggaa aaaccgcgcc tgcgtagctc
     8821 gcaggccagg gccgtcagcg ccaggggatc ggaatccccc cagtccgccg cggaattggc
     8881 ccagacacgg tccattccgt acaattccag aatatccgcc gcccgcttgg gattcagctt
     8941 gctggtggga taaagggtca gcccggccca gtaaccggcc tccttcacca gcgggaaggt
     9001 atgttcctca cagtgatcca ccagcacgcg gcaagggtcc agatccggac ggtttttcag
     9061 ggcggaaaga atcattacgg tccccttaag cttgtcttcc agatggggag tgtgaatcag
     9121 cacaagctgg ttgaggcgca ccgccagatc cagatgctct tcaaaaatag tcatttcatg
     9181 ggaagtattc cggttcagcc ctatttcccc gatgccgagg acattgggcc ggtcaatgaa
     9241 ctccggaatc agtttcatca catcccgcgc gaaagccacg tcctgcgcct ccttgggatt
     9301 gatgcacagc catgtgtaat ggtccatgcc gaacttggcc gccctggcgg gttcgcattc
     9361 cgtaagctgt acgaaataat cccggaaacc gtccgcggac gaacggtcgt aaccggccca
     9421 gaacgccggt tcccctaccg ccaggcagcc ggcctgcgcc atggcccggt attcgtccgt
     9481 ggtgcggcac accatatgta tatgaggttc tatgaaagcc atcattctta tttgctgagg
     9541 ttcggggctc cgcaggccgc tttggctgcg gcggtttccg gcacggtgtc atccctgtag
     9601 gaaagggctt ccagaatggc ccggacgcgt ccggggccgg atgcggacaa gaggggaaga
     9661 acatccatca gggcatggta gcggaaatcc gcctcccctt ccccgcggtc cacccggtcc
     9721 agaaatgcgg ccacatccag aacgccggcg cgcgccgctg cgaaatccgc gtccagcacc
     9781 tcctttttac ttcttttcat gcacagacga tacgcctatg cggaaagcct cgtcaagccg
     9841 gaacaggcaa caaaatgata accattccaa actgataaac agcaacctct ttccccggtt
     9901 tttcaaaaat ccgaaaagcg ccggaaattc aagaagaggc ttgccatccg ggcttgaacc
     9961 gggcatcctg tgaagacgca tttatttcat tagagcgcct atgaatgcac tagtaaaaac
    10021 catatgtaca ttcgtgacat cctccatcgg ccgcaaaatc attgtggctc tgacggggtt
    10081 atgtttggtc ttgttccttg cgggacacct ggcaggcaac cttctcatct tcggaggccc
    10141 tgaatggatc aacacctacg cccacggcct gcactccatg ccggaagcag ccctctgggg
    10201 aatccgcgcg gggcttgcgg tgatcttcat catccacgtc tggctgacca tccagctgaa
    10261 gctggaaaac catgcggccc gcgaacccta cgtgttcaag aacaccatta aggcaacgct
    10321 ctcctcccgc tacatgatct ataccggttt gaccgtcctg gtgttcctga tctaccacct
    10381 gtaccagtac accctgcgcg tgggatacga ccccgcccag ttcaccacct ttatttccga
    10441 cggtacggtg gaaacctttg acgtgtacaa gatgatcgtg accggattct ccaacgtatg
    10501 gtgctccgcc ttctacatcc tggccgttct gatgctgttc agccatctgc gccacggggt
    10561 acagtccatc ttccagactg tgggcgtcga ttcccgcaaa atccggccct tctacaactt
    10621 tatcgccatc gcctacggcg cgattatctg cctgggcttc atctccgtgc cggtctcggt
    10681 tcttctgggt atcatcaaat aaccatcaac tcctctcaaa gtcatgatta attttcccgt
    10741 aagcgactgg atgccggatg ccaaaattcc ctccggccct attcaggaca aatggtccaa
    10801 gtacaaactt gagtccaaac tgatcaatcc gaacaacaag cgcaagtaca cggtacttgt
    10861 ggtaggttcc ggcctggctg gcgcctccgc tgccgccacg cttgccgaac ttggctacaa
    10921 cgtcaaatgc ttctgctacc aggacagccc ccgccgcgcc cactccattg cggcccaggg
    10981 cggcattaac gcggccaaga actaccagaa cgacggcgac tccgtttacc gcctgtttta
    11041 cgacaccgtt aaaggcggcg acttccgcgc ccgtgaagcc aatgtctacc gtctggcgga
    11101 agtctcctcc aacatcattg accagtgtgt ggcccagggc gttcccttcg gccgtgaata
    11161 cggcggcctg ctggacaacc gctccttcgg cggcgcccag ctcaagcgaa ccttctacgc
    11221 acgcggacag acgggccagc agctcctgct gggtgcctac caggccctgg aaaaggaagt
    11281 ggccaaggga cacattgaaa tgttctcccg ccatgaaatg atggatctgg tgctggtgga
    11341 cggcgaagcc aagggcatcg tcacccgcaa tctggttacc ggcgaaatca aatcctacgc
    11401 aggggatacc gtcctgctct gcacgggcgg ctacggcaac gtgttcttcc tgtccaccaa
    11461 cgcgatgggt tgcaacgtca ctgccgccta caaagcctac aagcgtggtg ccttcttcgc
    11521 caacccctgc ttcacgcaaa tccaccccac ctgcattccg gtcaaaggcg actaccagtc
    11581 caaactgacg ctgatgtcgg aatccctccg caacagcggc cgcatctggg tgcccaagtc
    11641 ccgtgaaacc gcagaaaaaa tccgtaagaa ggaaatcaag ccttccgatg ttcccgaaga
    11701 agaacgggac tactacctgg aacgcaagta tccctccttc ggcaacctgg ctccgcgcga
    11761 catttcctcc cgcgccgcca aggaagcctg cgacgacggc cgcggcgtgg ccgtcaccgg
    11821 caagggcgtc ttcctggatt ttgcggatga aatcaagcgc atgggccgcg aatggattga
    11881 cggccaatac ggtaatctgt ttgacatgta cgaagaaatc acggacgacg acccccatga
    11941 aacgcccatg atgatctacc ccgcctccca ctacaccatg ggcggcctgt gggtggacta
    12001 caacctcatg tccaacgtga aggggctgca cgtcctcggt gaagccaact tctccgacca
    12061 cggcgccaac cgcctgggag cctccgccct gatgcagggc ctgtctgacg gctacttcgt
    12121 cattcccgcc acgctgcccg cttacctgac gaccaccaag cccggcgccg tcaccaccgc
    12181 cgccccggaa ttcaaggctg cggaagacga agtgaaggaa cgcatcaaca agctcctgaa
    12241 tgtgaagggc accaagacgg tggactcctt ccaccgggaa ctgggcctca tcatgtggga
    12301 agactgcggc atggcccgca cggaagaaag cctgacccac gccattgaac gcattcccca
    12361 gctccgcaag gaattctggg aaaacgtgcg cgtaaccggc acggcggacg gtatcaacgc
    12421 ggaactggaa aaagcctgcc gcgtggccga cttcctggaa ttcgcccagc tgctctgcta
    12481 tgacgccctg aaccgccagg aatcctgcgg cgcccacttc cgcgtggaat accagttgcc
    12541 ggacggcgaa gctaagcgca acgacgatga atacgcctat gtagccgcct gggaatacac
    12601 tggcgtggac agcctgcctg ttctccacaa ggaaccgctg accttcgaga acgtgcacct
    12661 tgccatccgc agctacaagt aaagatagcc aatacattaa cactcaaaag aaagattata
    12721 acatggctaa aacactcaat ctcactctca aggtctggcg ccaggaaaac cgggaagcca
    12781 agggccgcat tgagacctat gccgccaagg acattccggt ggacgcctcc ttcctggaaa
    12841 tgctggacat cgtcaatgaa ggcctggtca aggaaggcaa ggaacccatc cattttgacc
    12901 acgactgccg ggaaggcatc tgcggcatgt gctccctgac catcaacggc attccccacg
    12961 ggccggaacg ccaggtgacc acttgccagc ttcacatgcg caagttcaag gatggcgata
    13021 ccgtctggat tgaacccttc cgcgcgaagg ctttcccaat cctgcgggac ctgatggtgg
    13081 accgctccgc cctggaccgc atcatcgccg ctggaggcta tattgacgtg cgtaccggtt
    13141 ccgcgccgaa cgccaacaac atcgccgtgg aaaaagtgaa ggcggacgcc gcctttgacg
    13201 cggccgcctg catcggctgc ggcgcctgcg tggcctcctg taaaaacgct tccgccatgc
    13261 tgttcacctc cgccaagatc gcccatctca atctgctgcc gcagggccag ccggaacgtt
    13321 ccaagcgcgt cctggccatg atgaagcaga tggaagcgga aggctttggc aactgcacga
    13381 accagtatga atgtgaagcc gcctgcccga aaggcatcag cgtggacaac atcgcccgcc
    13441 tcaaccgcga cttcatgcgg gccaacgcca aggaaggcct ctgtttctaa agaagattcc
    13501 ttcttaagac gctctgtaaa aactcccggc ggcatcggct gtcgggagtt ttttcattac
    13561 cagatttcct tgaaccagga ataaaatacc agacagttgc ttcctcatcg tcgcgcagcg
    13621 taaaaaattg ttacaccgga aggcacccag taatccagga gaccgtactt ggaaatgccg
    13681 gacgaaacct aagcaagccc c
//
