LOCUS       c00049_gnlPro..        13882 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EDJIFBFH_49.
ACCESSION   c00049_gnlPro..
VERSION     c00049_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 11:06:43
            Original ID  :: gnl|Prokka|EDJIFBFH_49
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13882
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13882
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[392:3882]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      393..3882
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13882
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13882
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(393..1160)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_1"
                     /sec_met_domain="Fer2_3 (E-value: 4.1e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 1.4e-10, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 7.8e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(1201..3159)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 7.6e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 2.2e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(3181..3882)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_3"
                     /sec_met_domain="SucD_FumR (E-value: 4.7e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             4083..4355
                     /locus_tag="ctg49_4"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             4358..5173
                     /locus_tag="ctg49_5"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(5207..5440)
                     /locus_tag="ctg49_6"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(5872..6579)
                     /locus_tag="ctg49_7"
                     /transl_table=11
                     /translation="MNKLLSTLILSVGMSLSATAATSLLDSSIVGYSDFASQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLSKINTPDAYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSTTYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             7097..8170
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_synthase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_8"
                     /sec_met_domain="NAD_synthase (E-value: 1.1e-09, bitscore:
                     30.6, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VARILVGLSGGVDSSVAAALLVEQGHDVVGAYMKNWVNDEGIPGE
                     CPWEQDIQDALAVAKTTGIEFRVIDLVDEYRARIVNYLIEGYRAGYTPNPDVLCNREMK
                     FGVFLDYALEQGFDYVATGHYARRMDTPQGAFILRGRDPNKDQSYFLSLMRPDQIARAV
                     FPLGDLLKPEVRVLAEKYGLPTARKKDSQGICFIGQVKMSDFLRHYLPDKPGKIVDTEG
                     RTLGTHNGLHLFTMGQRKGHGVASPREGVAYVVVGKDVQRNRLILGYEDASTRGLYASR
                     AVVGGISNTLAPLPARVMAQPRYRAKAEWASCEYLEEGKVRLGFDTPLRALAVGQVCAF
                     YDGGKLLGGGFFESIEP"
     CDS             8167..9516
                     /locus_tag="ctg49_9"
                     /transl_table=11
                     /translation="MTDPERTIAAQATAAGQGAIAVIRMSGPGCMDILKQCTPAAFTER
                     LRPRRATLVCIRDAEGAAIDQALVTWFPAPASYTGEDTAEISCHGGMLVTDRLLKRLYQ
                     CGASPAEPGEFTKRAFLNGRMDLTQAEAVMDVISAGSDLALKAAQTQLDGGIGAQVDEL
                     KDNLVHVLAHIEAYIDFPDEDISPDTASDLLARLRSMEEKLTALLKTAEGGRLLREGIR
                     TAIAGPPNVGKSSLLNTLLGYDRAIVSNIAGTTRDTVEESIQLAGLALRLIDTAGVRES
                     SDVIEQAGITRTNRALETADLVLEVADASTPRIQDFPAPVLTAPRLLILNKCDLGVHPD
                     WKAVPGIRFSCATGEGRKELEEAIIQAFSSSLPGETGSSLVAINARHQHELGLCREHVR
                     LASESISRQESPEFTALELREALTHLGEITGAVDTEDVLGAIFSSFCLGK"
     CDS             9661..10518
                     /locus_tag="ctg49_10"
                     /transl_table=11
                     /translation="MLRTLSLFFLFALVPVQAAIYFAHNVSEDSGFINTKKYWNGDSDL
                     CWAATASNMLQWWQNNSSGIPAFVPNGQNESGRTEIYDVFCNNWANTGKGIEIGLRWYL
                     GGKPLNPNNYLYDFKETITEPQNTGRYWEGYITSLGLSSSTWEGDCPFISSKYFTQSDF
                     PLQFGTDLVSFFQNGGVVGLSIAPASGPGHAITCWGIEVDDTTGMAKSLYVTDSDNGQG
                     LEKRDVYYHETDGTLHLGSKNGPRINAYDALMLPFHNVPEPSTAVLTTLAAGTAFCRRR
                     RRRS"
     CDS             complement(10544..11197)
                     /locus_tag="ctg49_11"
                     /transl_table=11
                     /translation="MFLSTCEIMSTIIGALAGSIASSRVKMDLFGVIVCGTLAALGGGT
                     VRDILLDIPVYWTLPSGEIFVLASVVTSLATFYVAQKYPPPMGTIRVADAIVLALFGMI
                     GTEKSYLHGYTPTVSVMMGICTGVAGGLLRDVLTGNVPYVFRPGELYATAALLGGVAYA
                     VLYYAGIDSSTCFVTGFMVTLSVRLAAIRWNWNLPSYIPLFTSDTDSPPEEPET"
     CDS             complement(11226..12005)
                     /locus_tag="ctg49_12"
                     /transl_table=11
                     /translation="MMQFCVLGSGSGGNATIVRAGETVLLVDAGFSAARLRDKMKSAGV
                     EPDELDAILLTHEHADHMKGVHQFTRKHAVRVYATRHTAMCVQEKAPEAPWAYFEKGQS
                     FRIGDIVITPFPTYHDAVDPVGFKFETERSSLGFISDTGQAPGCIAEYLAMVDSLVVES
                     NYDPDMLAATPRRPWPLKQRIASAHGHLSNEQACDLLRRIAHGALKNVVLAHLSAESNS
                     PALAESLMRDTLHDMGLASTSLFCASQDSCLPWIRVC"
     CDS             12163..12618
                     /locus_tag="ctg49_13"
                     /transl_table=11
                     /translation="MSSVSDNLFGAYTHKLDPKNRIAIPAEWRPSEGCALLLLSGRRLD
                     LPTVKAYTREKFQQLIDKIETTPGYTEAQIDLFIGKLYANCVEAVINAQGKLLIPKQMC
                     EHAQLSSSVRLAARRGYFELWEPSLYEEVSRRENASISDINQSYGIL"
ORIGIN
        1 attataattc ttacgctcaa cacctccctg ttatggacat caatgttgtc tgtttgttag
       61 aaaatatttt cctctcatgc agaacccttg acaggatgcc atcccttccg ggcatcagtc
      121 caattcctgt aatcaatgtt tctttctctc gaagaaagat gggggccgtc gctgtcggac
      181 gggggcttgc ttaggtttcg tccggcattt ccaagtacgg tctcctggat tactggaacc
      241 cttccggtgt aacaattttt tacgctgcgc gacgatgagg aagcaactgt ctggtatttt
      301 attcctggtt caaggaaacc tggtaatgaa aaaactcccg acagccgatg ccgccgggag
      361 tttttacaga gcgtcttaag aaggaatctt ctttagaaac agaggccttc cttggcgttg
      421 gcccgcatga agtcgcggtt gaggcgggcg atgttgtcca cgctgatgcc tttcgggcag
      481 gcggcttcac attcatactg gttcgtgcag ttgccaaagc cttccgcttc catctgcttc
      541 atcatggcca ggacgcgctt ggaacgttcc ggctggccct gcggcagcag attgagatgg
      601 gcgatcttgg cggaggtgaa cagcatggcg gaggcgtttt tacaggaggc cacgcaggcg
      661 ccgcagccga tgcaggcggc cgcgtcaaag gcggcgtccg ctttcacttt ttccacggcg
      721 atgttgttgg cgttcggcgc ggaaccggta cgcacgtcaa tatagcctcc agcggcgatg
      781 atgcggtcca gggcggagcg gtccaccatc aggtcccgca ggattgggaa agccttcgcg
      841 cggaagggtt caatccagac ggtatcgcca tccttgaact tgcgcatgtg aagctggcaa
      901 gtggtcacct ggcgttccgg cccgtgggga atgccgttga tggtcaggga gcacatgccg
      961 cagatgcctt cccggcagtc gtggtcaaaa tggatgggtt ccttgccttc cttgaccagg
     1021 ccttcattga cgatgtccag catttccagg aaggaggcgt ccaccggaat gtccttggcg
     1081 gcataggtct caatgcggcc cttggcttcc cggttttcct ggcgccagac cttgagagtg
     1141 agattgagtg ttttagccat gttataatct ttcttttgag tgttaatgta ttggctatct
     1201 ttacttgtag ctgcggatgg caaggtgcac gttctcgaag gtcagcggtt ccttgtggag
     1261 aacaggcagg ctgtccacgc cagtgtattc ccaggcggct acataggcgt attcatcgtc
     1321 gttgcgctta gcttcgccgt ccggcagctg gtattccacg cggaagtggg cgccgcagga
     1381 ttcctggcgg ttcagggcgt catagcagag cagctgggcg aattccagga agtcggccac
     1441 gcggcaggct ttttccagtt ccgcgttgat gccgtccgcc gtgccggtta cgcgcacgtt
     1501 ttcccagaat tccttgcgga gctggggaat gcgttcaatg gcgtgggtca ggctttcttc
     1561 cgtgcgggcc atgccgcagt cttcccacat aatgaggccc agttcccggt ggaaggagtc
     1621 caccgtcttg gtgcccttca cattcaggag cttgttgatg cgttccttca cttcgtcttc
     1681 cgcagccttg aattccgggg cggcggtggt gacggcgccg ggtttggtgg tcgtcaggta
     1741 agcgggcagc gtggcgggaa tgacgaagta gccgtcagac aggccctgca tcagggcgga
     1801 ggctcccagg cggttggcgc cgtggtcgga gaagttggct tcaccgagga cgtgcagccc
     1861 cttcacattg gacatgaggt tgtagtccac ccacaggcca cccatggtgt agtgggaggc
     1921 ggggtagatc atcatgggcg tttcatgggg gtcgtcgtcc gtgatttctt cgtacatgtc
     1981 aaacagattg ccgtattggc cgtcaatcca ttcgcggccc atgcgcttga tttcatccgc
     2041 aaaatctagg aagacgccct tgccggtgac ggccacgccg cggccgtcgt cgcaggcttc
     2101 cttggcggcg cgggaggaaa tgtcgcgcgg agccaggttg ccgaaggagg gatacttgcg
     2161 ttccaggtag tagtcccgtt cttcttcggg aacatcggaa ggcttgattt cctttttacg
     2221 gattttttct gcggtttcac gggacttggg cacccagatg cggccactgt tgcggaggga
     2281 ttccgacatc agcgtcagtt tggactgata gtcgcccttg accggaatgc aggtggggtg
     2341 gatttgcgtg aagcaggggt tggcgaagaa ggcaccgcgc ttgtaggcct tgtaggcggc
     2401 agtgacgttg cagcccatcg cgttggtgga caggaagaac acgttgccgt agccgcccgt
     2461 gcagagcagg acggtatccc ctgcgtagga tttgatttcg ccggtaacca gattgcgggt
     2521 gacgatgccc ttggcttcgc cgtccaccag caccagatcc atcatttcat ggcgggagaa
     2581 catttcaatg tgtcccttgg ccacttcctt ttccagggcc tggtaggcac ccagcagtag
     2641 ctgctggccc gtctgtccgc gtgcgtagaa ggttcgcttg agctgggcgc cgccgaagga
     2701 gcggttgtcc agcaggccgc cgtattcacg gccgaaggga acgccctggg ccacacactg
     2761 gtcaatgatg ttggaggaga cttccgccag acggtagaca ttggcttcac gggcgcggaa
     2821 gtcgccgcct ttaacggtgt cgtaaaacag gcggtaaacg gagtcgccgt cgttctggta
     2881 gttcttggct gcgttaatgc cgccctgggc cgcaatggag tgggcgcggc gggggctgtc
     2941 ctggtagcag aagcatttga cgttgtagcc aagttcggca agcgtggcgg cagcggaggc
     3001 gccagccagg ccggaaccta ccacaagcac cgtgtacttg cgcttgttgt tcggattgat
     3061 cagtttggac tcaagtttgt acttggacca tttgtcctga atagggccgg agggaatttt
     3121 ggcatccggc atccagtcgc ttacgggaaa attaatcatg actttgagag gagttgatgg
     3181 ttatttgatg atacccagaa gaaccgagac cggcacggag atgaagccca ggcagataat
     3241 cgcgccgtag gcgatggcga taaagttgta gaagggccgg attttgcggg aatcgacgcc
     3301 cacagtctgg aagatggact gtaccccgtg gcgcagatgg ctgaacagca tcagaacggc
     3361 caggatgtag aaggcggagc accatacgtt ggagaatccg gtcacgatca tcttgtacac
     3421 gtcaaaggtt tccaccgtac cgtcggaaat gaaggtggtg aactgggcgg ggtcgtatcc
     3481 cacgcgcagg gtgtactggt acaggtggta gatcaggaac accaggacgg tcaggccggt
     3541 atagatcatg tagcgggagg agagcgtcgc cttgatggtg ttcttgaaca cgtagggttc
     3601 gcgggccgca tggttttcca gcttcagctg gatggtcagc cagacgtgga tgatgaagat
     3661 caccgcaagc cccgcgcgga ttccccagag ggctgcttcc ggcatggagt gcaggccgtg
     3721 ggcgtaggtg ttgatccatt cagggcctcc gaagatgaga aggttgcctg ccaggtgtcc
     3781 cgcaaggaac aagaccaaac ataaccccgt cagagccaca atgattttgc ggccgatgga
     3841 ggatgtcacg aatgtacata tggtttttac tagtgcattc ataggcgctc taatgaaata
     3901 aatgcgtctt cacaggatgc ctggttcaag cccggatggc aagcctcttc ttgaatttcc
     3961 ggcgcttttc ggatttttga aaagccgggg aaagatgttg ctgtttatca gtttggaatg
     4021 gttatcattt tgttgcctgt tccggcttga cgaggctttc cgcataggcg tatcgtctgt
     4081 gcatgaaaag aagtaaaaag gaagtgctgg acgcggattt cgcagcggcg cgcgccggcg
     4141 ttctggatgt ggccgcattt ctggaccggg tggaccgcgg ggaaggggag gcggatttcc
     4201 gctaccatgc cctgatggat gttcttcccc tcttatccgc atccggcccc ggacgcgtcc
     4261 gggccatcct ggaagccctt tcctacaggg atgacaccgt gccggaaacc gccgcagcca
     4321 aagcggcctg cggagccccg aacctcagca aataagaatg atggctttca tagaacctca
     4381 tatacatatg gtgtgccgca ccacggacga ataccgggcc atggcgcagg ccggctgcct
     4441 ggcggtaggg gaaccggcgt tctgggccgg ttacgaccgt tcgtccgcgg acggtttccg
     4501 ggattatttc gtacagctta cggaatgcga acccgccagg gcggccaagt tcggcatgga
     4561 ccattacaca tggctgtgca tcaatcccaa ggaggcgcag gacgtggctt tcgcgcggga
     4621 tgtgatgaag ctgattccgg agttcatcga ccggcccaat gtcctcggca tcggggaaat
     4681 aggactgaac cggaatactt cccatgaaat gactattttt gaagagcatc tggatctggc
     4741 ggtgcgcctc aaccagcttg tgctgattca cactccccat ctggaagaca agcttaaggg
     4801 gaccgtaatg attctttccg ccctgaaaaa ccgtccggat ctggaccctt gccgcgtgct
     4861 ggtggatcac tgtgaggaac ataccttccc gctggtgaag gaggccggtt actgggccgg
     4921 gctgaccctt tatcccacca gcaagctgaa tcccaagcgg gcggcggata ttctggaatt
     4981 gtacggaatg gaccgtgtct gggccaattc cgcggcggac tggggggatt ccgatcccct
     5041 ggcgctgacg gccctggcct gcgagctgcg caggcgcggt ttttcccggc aggaaacgga
     5101 acgtcttctc ctggaaaatc cggagacatt catgggacag tccccgaagt tccggaaagt
     5161 gtcgtcccgc taattccgcc cgaggcgcgg cggagggtac ggccctctag tccccgtccg
     5221 ggaaaaagac ggtgaggacg gcgcccagga tgaccgccgc gtcatccaga aggcccagcc
     5281 tgccgattcc gtcaaacagg aattcgtcgg gagtcaggat gtaggcgccg gcggcggcca
     5341 gaaggcatat attccgtttg ttgaaaaaac gcggttctcc ttttctgctt ttgaaatacc
     5401 ggaacaggcg cagtagcagc tgctgttttt gaaggttcat ggacgggaac gggggataaa
     5461 ggttcaagct cagccatttt cccactcctt ttccctgttt cggggaagga gtctgttgcc
     5521 gacggacgga aaccgcagcg atccggaccg tgcggggaaa tggattgctg aaaggatggg
     5581 ctgttccgga tgctgaggga agccgggctt tgcatgctcc ggttccggct gtcccggcat
     5641 gggaaaaagg ggcgtgtacg gaagtggggc ggggccggaa gctcttgaaa tgaccctccc
     5701 gggggagcct gaatgccatt tccccgtcaa gtgctggccg tgagggtacc gcagcaaatg
     5761 gaagcttctt cccccctgtt ttttccggca gatgtttgaa cggataagga aaaggccggc
     5821 tcacgatttt gtgagccggc ctttgaatat agggaggcgg acggtacagg cttatgccct
     5881 gcggcggcgc atcatcagcg cggccagtcc cagcaggccc agggaagccg tggcgggttc
     5941 cgggatgctg gcgatttcac tcatcagttg accaacttgt tcctgggaaa ggagggagtc
     6001 gtgaatgtag agctgttcga tggattcagc cagtcctgcg tccatgagaa tctgatcaat
     6061 ttgctggttg ccgaatttca ggccgctgtt ggaatagtac gtagtgctgt ctccaaaata
     6121 gatgcgggtg ccaagatctc cggtgactac ggaaatggtc agggaacctt ccgtgcccag
     6181 cggggtgtca acgacaggcc cgctgtagga ggtgttgttc cataatccct ggagtttccg
     6241 gtccgtgttc aggcccacgc cccagcttac actgctgttt ttggcgttaa acagagcggt
     6301 ataggcgtcc ggagtgttga ttttggacag gtcaagaacc atcgtcacag acataacgtc
     6361 gcggttgttg gcaccgtatc cgttgaaggt tatcccggat aacgtcagat tgctgtcgtc
     6421 agacgtgatg gaaacggaat ctttcagggt gccgaaatcc gccgtttggg aggcaaagtc
     6481 cgaatatccc acgatggagc tatccagcag agaggtagcc gcggtagcgc ttaggctcat
     6541 gccgaccgaa agaatcaggg tggataataa tttattcatg gtcagtatct taataaaatg
     6601 atgcaagatt caatgtatgt acttgtgctt gaataacgaa tttggaatcc gtagcttttt
     6661 tccaggtggc ctccgttctc cggcagactg aaatcatcag accaccgcat tctgaaaaac
     6721 tgaatatgcc attgaacaac aattttttag ttaatacctc ctcatctttc ctcatcacgg
     6781 aaatacctcc tgaaaaaaaa tgaagggcct tacctctcca tattccagct tcctgtttaa
     6841 agaggtggta aattaattat aatacttttt tctaatttat tatattgact acggattcca
     6901 aattcgattt cagggaatgt gattaaaaat caaaagcctc ccggatcgac cgaatcatat
     6961 tccgcatcag ggaccggatg ccccatttcc acgctttttg tcttggctta cggaaacatc
     7021 tttggtttac aggggcaggc ggcaaagcct ttctcaaagc ggtccgcctt atcaccccca
     7081 tatcttttcc agcatcgtgg cacgcatact tgtaggctta tcaggcggag tggacagctc
     7141 cgtggcagcg gccctgctcg tggagcaggg ccatgacgta gtgggggcct acatgaaaaa
     7201 ctgggtgaat gacgaaggca ttcccggcga atgcccgtgg gaacaggaca ttcaggacgc
     7261 tctggccgtc gccaaaacaa caggtattga attccgggtc attgacctgg tggacgaata
     7321 ccgcgcccgc atcgtgaatt atctgattga aggctaccgc gccggatata cgcccaaccc
     7381 ggacgtattg tgcaatcggg aaatgaaatt cggcgtcttt ctggattatg ccctggaaca
     7441 ggggttcgac tacgtcgcca ccggccatta cgcccgcagg atggacacgc cgcaaggggc
     7501 tttcatcctg cgcgggcggg acccgaacaa ggatcaatcc tacttcctgt ccctgatgcg
     7561 cccggaccag atagcccgcg ccgtctttcc ccttggggat ctgctgaaac cggaagtgcg
     7621 cgttcttgcg gaaaaatacg gcctccccac ggcacgcaag aaagacagcc agggcatctg
     7681 tttcatcggc caggtaaaaa tgagcgattt cctgcgccac tacctgccgg acaagcccgg
     7741 caaaatcgtg gacacggaag gccggacgct cggcacgcac aacggcctgc atctgttcac
     7801 catgggccag aggaaagggc acggcgtcgc ctccccgcgg gagggagtcg cctatgtggt
     7861 ggtgggaaag gatgtccagc gcaaccgcct gattctggga tacgaagacg cgtccacgcg
     7921 gggattgtac gcgtcccgcg ccgtggtcgg cggcatttcc aatacgctcg ctcccctgcc
     7981 ggcccgcgtc atggcccagc cccgctaccg ggccaaggcg gaatgggcct cctgcgaata
     8041 tctggaagaa ggaaaggtgc gcctgggctt tgacacgccc ctccgggccc tggccgtggg
     8101 acaggtctgc gccttttacg acggaggcaa gttgctcggg ggcggctttt ttgaatccat
     8161 agaaccatga ctgacccgga acgcaccata gccgcacagg ccaccgccgc aggacaggga
     8221 gccatcgccg tcatccgcat gagcggtccc ggctgcatgg acatcctgaa acaatgcacc
     8281 cctgcggctt tcacggaacg cctccgtccg cgcagggcga cgctggtctg catccgggac
     8341 gcggaaggag ccgccattga ccaggcgctt gtcacctggt tccccgcccc ggccagttat
     8401 acgggggaag ataccgcgga aatctcctgc catggcggca tgctggtgac ggaccgcctg
     8461 ctgaaacgcc tctaccaatg cggggcctcc ccagcggaac cgggagaatt tacaaaaagg
     8521 gcctttctga acgggcgcat ggacctgacc caggcggaag ccgtgatgga tgtgatttcc
     8581 gccgggagcg acctggccct gaaagccgcg cagacccagc tggacggagg catcggcgcc
     8641 caggtggacg aactgaaaga caacctggtt catgtgctgg cccacattga ggcctatatt
     8701 gattttccgg atgaagacat ttccccggac accgcctccg atctgctggc gcgcctccgg
     8761 agcatggagg aaaaactgac cgccctcctc aaaactgccg aaggcggacg cctgctgcgg
     8821 gaaggcatcc gcacggcgat cgccggacct cccaacgtgg gaaaatccag cctgctgaat
     8881 accctgctgg gatatgaccg ggccattgtc agcaatattg ccggtaccac gcgggacacg
     8941 gtggaggaat ccattcagct ggccgggctg gccctgcggc tgattgatac ggccggtgtc
     9001 cgcgaatctt ccgacgtcat tgaacaggca ggcattaccc gcaccaacag ggctcttgaa
     9061 accgcggatc tggttctgga agtggcggat gcctccacgc cccggatcca agacttcccc
     9121 gcccctgttc tcaccgcgcc ccggctgctc attctgaaca agtgcgacct gggagtccat
     9181 ccggactgga aggccgtgcc cggcatccgg ttttcctgcg ccaccgggga aggaagaaag
     9241 gaattggagg aagccattat ccaggccttt tcctcctccc tgcccggtga aacgggcagc
     9301 tccctggtag ccatcaatgc ccggcaccag catgaactgg gcctctgccg ggagcatgtc
     9361 cggctggctt cggaatccat ctcccgccag gaaagtccgg aattcacagc cttggaactg
     9421 agagaggccc tgacgcacct gggagaaatc accggagccg tggatacgga ggacgtgctg
     9481 ggcgccattt tttcctcctt ctgcctgggg aaataagaag aagcttccat caacaggttt
     9541 ttctgactcc agattcttct ttcctctcca ttctgtggaa ggatggcaat catccaaaaa
     9601 tttatttgcg gatattttca ttgattccgg cttgttaatt cgctatcgat atcatgtttt
     9661 atgttgcgca ccctttctct ctttttcctt ttcgctctgg ttcctgttca agccgccatt
     9721 tattttgccc ataatgtttc cgaagattcg gggttcataa ataccaaaaa atactggaac
     9781 ggagattccg atttatgctg ggcggccaca gccagcaata tgctgcaatg gtggcagaat
     9841 aattcctccg gcattccggc tttcgttccc aacggccaga atgaaagcgg aagaacggaa
     9901 atttacgatg tgttttgcaa taattgggcc aataccggga aaggcataga aataggcctg
     9961 cggtggtacc tgggagggaa acctctcaat cccaacaatt atttatacga ttttaaggaa
    10021 accatcactg aaccgcagaa tactggccga tactgggagg gatacattac atctctggga
    10081 ttgtcctctt ccacctggga aggcgactgc cctttcatca gcagcaaata cttcacgcaa
    10141 agcgattttc ccctccagtt cggtacagac ctcgtctcat ttttccagaa tggcggcgta
    10201 gtgggacttt ccattgctcc tgcatcaggt ccgggtcatg ccattacctg ctggggaatt
    10261 gaggttgacg acactaccgg catggccaaa tccctgtacg tcacagactc cgacaacgga
    10321 caaggtctgg aaaaacggga cgtttattat catgaaacgg atggaaccct gcacttgggg
    10381 agcaagaacg gccctcgaat caacgcatac gacgccctga tgctgccctt tcataatgtt
    10441 ccggaacctt ccacggcagt tctcaccacc ctcgcggcgg gaactgcctt ttgccgccgc
    10501 aggcgccgac gctcttaagg cttcacggaa acattccctc ctgtcaagtt tccggctctt
    10561 caggaggcga atcggtatcc gaggtgaata acggaatgta ggaaggcagg ttccagttcc
    10621 agcggatggc cgccaggcgt acggaaagcg tgaccatgaa gcccgtcacg aagcaggtgg
    10681 aagaatcaat tccggcatag taaagcaccg cgtacgccac gcctcccagc agggccgcgg
    10741 tggcgtataa ttctccggga cggaacacgt agggaacgtt gccggtaagc acgtcgcgca
    10801 gcaggccgcc cgccacgccg gtacaaatgc ccatcatcac ggaaacagtg ggcgtatagc
    10861 cgtggagata ggatttttcc gtgccgatca tgccgaagag agccagaacg atagcatccg
    10921 ccacgcggat agtgcccatg ggaggcggat atttctgggc cacataaaag gttgccaggc
    10981 tggtgacgac agaggccagg acaaaaattt ccccggaggg gagcgtccag tacaccggta
    11041 tgtccagcag gatgtcgcgc acggttccgc cgcccaacgc agccagggtg ccgcagacaa
    11101 tcacgccgaa caaatccatt ttcacccgcg aggaagcgat ggaacccgcc agggctccaa
    11161 taatcgtgct catgatttca caggtggaga ggaacatggc gggaggaaca ggaaaaaagg
    11221 catattcagc agacccgtat ccacggcagg caggagtcct ggctggcgca gaacagggag
    11281 gtggaagcca gccccatgtc atgcagggta tcacgcatca ggctttctgc caatgccgga
    11341 gaattgcttt ctgcgctcag gtgggccagc accacgtttt tcagggctcc atgggcaatc
    11401 cgcctcagca ggtcgcacgc ctgctcattg gacagatgcc cgtgcgcaga ggcgatgcgc
    11461 tgcttcagcg gccaaggcct cctgggagtg gccgccagca tgtccggatc atagtttgat
    11521 tccaccacca ggctgtccac catggcaagg tattccgcga tgcagccggg agcctgcccc
    11581 gtatcggaaa taaaacccag gctggatcgc tccgtttcaa atttgaatcc caccggatcc
    11641 acggcgtcat ggtaagtggg gaagggagta atgacgatat cccctattct gaaagactgc
    11701 cccttttcaa aataggccca gggagcctcc ggcgcttttt cctggacgca catggccgta
    11761 tggcgggtgg cgtaaacacg cacggcatgc tttctggtga actggtgcac gcctttcatg
    11821 tggtccgcgt gttcgtgggt aagcagaatg gcgtccagct catccggctc cactccggcg
    11881 gacttcatct tatcccgcag cctggcggcg ctgaacccgg catccaccag caggacggtt
    11941 tcccccgccc tgacaatggt ggcatttccc ccgctgccgc tgcccaacac gcaaaactgc
    12001 atcatgcgcg gaatataata ccgcccccgg aagggagcaa gaccgtatcc atgctttttt
    12061 ttatgacatg ggaacatgaa aaaatacttt tttccagtac ggggttgaca tttcaggtgc
    12121 attaaagtgt attgaagtca ctacgtagtg tacttgcatg cgatgagcag tgtatcagac
    12181 aacctttttg gtgcatacac gcacaagctg gaccccaaaa accggattgc cattccggcc
    12241 gaatggaggc cctccgaagg ttgcgccctg ctcctgttat ccggccggcg ccttgatttg
    12301 ccgaccgtca aagcctatac gcgggaaaaa ttccagcaac tcattgacaa gatagaaaca
    12361 acgcccggct atacggaagc gcaaatcgac ctgttcatcg gtaaattata cgccaactgt
    12421 gtggaggctg tcatcaacgc ccaaggcaag ctgctgatac ccaaacaaat gtgcgaacac
    12481 gcacagctca gttcctccgt ccggctcgcc gcgcggagag gatatttcga attgtgggag
    12541 ccctctctct atgaagaagt ttcccggcgt gaaaacgcca gcatctccga catcaaccaa
    12601 tcctacggca ttctctagct ttccttcatg cccccagact cttccattct gcccaatccc
    12661 caggcacgcc cctgcgcaac gcttgcattg cgcccgggct ggcttgcttc cggcctgggc
    12721 gtcggcgcca gaaccgggct gcatgcggaa ctcacggctt attccatcgt tttctggggg
    12781 cacgacgccc ttccggcgca ggatatggtt gcctggcaac aggaaaaagc acgccttatg
    12841 gaggaaatgt ccctggccgg gcaaaagagc gcctatggca agctgggcgc attgtcctcc
    12901 gacctgaacc gggcttttga cgaccatatt gagctttctt tacgcgcggg cgcgggtacg
    12961 cacatccgca cggaggaagt gcaggccctg gcaaacggac ttgcggaaga aacgtcctgc
    13021 cgcgtactgg cgtggagcgt ctgccgcaac catgtgcatg tggttgcgga gctgacggag
    13081 gagaagggag tggatgaact ggtctgctcc tggaaggcgc tggccccctc catgaactgg
    13141 gagaacgcgt accacacgga agccctgaaa gcccgggaag ccgcggcaag ggcggatgcc
    13201 ctgatttccg aacttgggga tgacgccttt gccgctgttg atgcggaagc ggacggaacc
    13261 gtctccggaa acggtttccg gcacattacc gttctgctgc atgaaacggt ggacatgctg
    13321 aaagcgggcc ccggcaaatt catcgtggac tgcacgcttg gcggcggggg ccacacggag
    13381 cttctgctgg aacagggcgc caccgtctgg ggcattgacc gcgatgcgga cgcccgccgc
    13441 gccgccatgc tcaggctggc gcgcttcggt tcccgtttca aggcgctcgc cggcaacttc
    13501 caggatgtgg aaagcattct ttcccagcag ggggtttccc gggtggacgg gctgctggcg
    13561 gatctgggcg tttcctccca ccagcttgac accgcctccc gcggtttttc ttttcgggaa
    13621 gacggccctc tggacatgcg gatggatacc cgcgccgcct tttccgcccg gaacctggtg
    13681 aatgaggccc cggaagaaga aatcgcagcc attctctggc aattcggaga ggaacgcgct
    13741 tcccgcgcca ttgcccgcgc cattgggaaa gcccgcgccc aggcccccat caccactacc
    13801 gcacagcttg cccgcatcgt ggaatccgtc ctgccgcgca aaggaaggca gcaccccggc
    13861 acccgcacgt tccaggccct ga
//
