LOCUS       c00028_gnlPro..        13794 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IEPJPLPJ_28.
ACCESSION   c00028_gnlPro..
VERSION     c00028_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 07:05:06
            Original ID  :: gnl|Prokka|IEPJPLPJ_28
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13794
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..291
                     /locus_tag="ctg28_1"
                     /transl_table=11
                     /translation="LDRMPSLPGISLIPVINVSLSRRKMGPSLSDGACLGFVRHFQVRF
                     PGLLGAFRCNNFLRCATMRKQLSGILFLVQGNLVMKKLPTADAAGSFYRAS"
     protocluster    1..13794
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[304:3794]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      305..3794
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13794
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13794
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(305..1135)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.6; E-value: 9.2)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_2"
                     /sec_met_domain="Fer2_3 (E-value: 1.8e-23, bitscore: 74.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 5.7e-11, bitscore: 34.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.1e-06, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPSAATSKDSQYINTQKKDYNMAKTLNLTLKVWRQENREAKGRIE
                     TYAAKDIPVDASFLEMLDIVNEGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPER
                     QVTTCQLHMRKFKDGDTVWIEPFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAP
                     NANNIAVEKVKADAAFDAAACIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSK
                     RVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(1113..3071)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.1e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.7e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 7.8e-38,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAITGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(3093..3794)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg28_4"
                     /sec_met_domain="SucD_FumR (E-value: 1.7e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             3995..4267
                     /locus_tag="ctg28_5"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             4270..5085
                     /locus_tag="ctg28_6"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(5119..5352)
                     /locus_tag="ctg28_7"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             5704..5883
                     /locus_tag="ctg28_8"
                     /transl_table=11
                     /translation="MFERIRKRPAHDFVSRPLNIGRRTVQAYALRRRIISAASPSRPRE
                     AVAGSGMLAISLIS"
     CDS             6034..6216
                     /locus_tag="ctg28_9"
                     /transl_table=11
                     /translation="MRVPRSPVTTEMVREPSVPSGVSTTGPLYEVLFHNPWSFRSVFRP
                     TPQLTLLFLALNRAV"
     CDS             6226..6513
                     /locus_tag="ctg28_10"
                     /transl_table=11
                     /translation="VLILDRSRTIVTDITSRLLAPYPLKVIPDNVRLLSSDVMETESFR
                     VPKSAVWEAKSEYPTMELSNRAVAAVALRLMPAERIRVDNNLFMVSILIK"
     CDS             complement(6522..6611)
                     /locus_tag="ctg28_11"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKHKYIH"
     CDS             complement(7037..7333)
                     /locus_tag="ctg28_12"
                     /transl_table=11
                     /translation="MPGAVNPPLIVTVSPSVLAVGAAVPPAAYKYVLDVSCIKSITDWL
                     TARKRYVNAASRSRGEPSREEKLNVRLIPAAVVPVLVLQPMTELSEPFSTRKP"
     CDS             complement(7744..7878)
                     /locus_tag="ctg28_13"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGHYVKAAVYHMDEKRAAEFDGIFR"
     CDS             complement(7990..8190)
                     /locus_tag="ctg28_14"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             complement(8383..9060)
                     /locus_tag="ctg28_15"
                     /transl_table=11
                     /translation="MGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENGR
                     PRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCEW
                     LSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSKK
                     PNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGXXXCPRKTPWSSSPAPLTSFAAVRGKTT
                     RTA"
     CDS             complement(9441..10214)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg28_16"
                     /sec_met_domain="adh_short_C2 (E-value: 1.7e-75, bitscore:
                     244.9, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILI
                     SRSPSSCGGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGIT
                     RDSLMLRMKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQA
                     NYAASKAGLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNSIPDNLKEEIVKKIPLKE
                     QGSVEDIAALTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(10316..10834)
                     /locus_tag="ctg28_17"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGTPPGA
                     LRENEEAGQ"
     CDS             complement(10898..12508)
                     /locus_tag="ctg28_18"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             12631..13338
                     /locus_tag="ctg28_19"
                     /transl_table=11
                     /translation="MPTTQTFRLLLAAALLCGWSSCCTPPAEDYIQQPYVQQQMSGLAN
                     AFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNRTVLFGWLNNILVNSNLRDRG
                     LCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCVYVNAAGKGLQGSIVLDAWKN
                     CGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGMEHHLVWPGWARKRPMLVQRIF
                     QSDQQNEAKAAAE"
ORIGIN
        1 cttgacagga tgccatccct tccgggcatc agtctaattc ctgtaatcaa tgtttctctc
       61 tctcgaagaa agatggggcc gtcgctgtcg gacggggcct gcttaggttt cgtccggcat
      121 ttccaagtac ggtttcctgg attactgggt gccttccggt gtaacaattt tttacgctgc
      181 gcgacgatga ggaagcaact gtctggtatt ttattcctgg ttcaaggaaa cctggtaatg
      241 aaaaaactcc cgacagccga tgccgccggg agtttttaca gagcgtctta agaaggaatc
      301 ttctttagaa acagaggcct tccttggcgt tggcccgcat gaagtcgcgg ttgaggcggg
      361 cgatgttgtc cacgctgatg cctttcgggc aggcggcttc acattcatac tggttcgtgc
      421 agttgccaaa gccttccgct tccatctgct tcatcatggc caggacgcgc ttggaacgtt
      481 ccggctggcc ctgcggcagc agattgagat gggcgatctt ggcggaggtg aacagcatgg
      541 cggaggcgtt tttacaggag gccacgcagg cgccgcagcc gatgcaggcg gccgcgtcaa
      601 aggcggcgtc cgccttcact ttttccacgg cgatgttgtt ggcgttcggc gcggaaccgg
      661 tacgcacgtc aatatagcct ccagcggcga tgatgcggtc cagggcggag cggtccacca
      721 tcaggtcccg caggattggg aaagccttcg cgcggaaggg ttcaatccag acggtatcgc
      781 cgtccttgaa cttgcgcatg tgaagctggc aagtggtcac ctggcgttcc ggcccgtggg
      841 gaatgccgtt gatggtcagg gagcacatgc cacagatgcc ttcccggcag tcgtggtcaa
      901 aatggatggg ttccttgcct tccttgacca ggccttcatt gacgatgtcc agcatttcca
      961 ggaaggaggc gtccaccgga atgtccttgg cggcataggt ctcaatgcgg cccttggctt
     1021 cccggttttc ctggcgccag accttgagag tgagattgag tgttttagcc atgttataat
     1081 ctttcttttg agtgttaatg tattggctat ctttacttgt agctgcggat ggcaaggtgc
     1141 acgttctcga aggtcagcgg ttccttgtgg agaacaggca ggctgtccac gccagtgtat
     1201 tcccaggcgg ctacataggc gtattcatcg tcgttgcgct tagcttcgcc gtccggcagc
     1261 tggtattcca cgcggaagtg ggcgccgcag gattcctggc ggttcagggc gtcatagcag
     1321 agcagctggg cgaattccag gaagtcggcc acgcggcagg ctttttccag ttccgcgttg
     1381 atgccgtccg ccgtgccggt tacgcgcacg ttttcccaga attccttgcg gagctgggga
     1441 atgcgttcaa tggcgtgggt caggctttct tccgtgcggg ccatgccgca gtcttcccac
     1501 ataatgaggc ccagttcccg gtggaaggag tccaccgtct tggtgccctt cacattcagg
     1561 agcttgttga tgcgttcctt cacttcgtct tccgcagcct tgaattccgg ggcggcggtg
     1621 gtgacggcgc cgggtttggt ggtcgtcagg taagcgggca gcgtggcggg aatgacgaag
     1681 tagccgtcag acaggccctg catcagggcg gaggctccca ggcggttggc gccgtggtcg
     1741 gagaagttgg cttcaccgag gacgtgcagc cccttcacat tggacatgag gttgtagtcc
     1801 acccacaggc cgcccatggt gtagtgggag gcggggtaga tcatcatggg cgtttcatgg
     1861 gggtcgtcgt ccgtgatttc ttcgtacatg tcaaacagat tgccgtattg gccgtcaatc
     1921 cattcgcgac ccatgcgctt gatttcatcc gcaaaatcca ggaagacgcc cttgccggtg
     1981 atggccacgc cgcggccgtc gtcgcaggct tccttggcgg cgcgggagga aatgtcgcgc
     2041 ggggccaggt tgccgaagga gggatacttg cgttccaggt agtagtcccg ttcttcttcg
     2101 ggaacatcgg aaggcttgat ttccttttta cggatttttt ctgcggtttc acgggacttg
     2161 ggcacccaga tgcggccgct gttgcggagg gattccgaca tcagcgtcag tttggactgg
     2221 tagtcgccct tgaccggaat gcaggtgggg tggatttgcg tgaagcaggg gttggcgaag
     2281 aaggcaccgc gcttgtaggc cttgtaggcg gcagtgacgt tgcagcccat cgcgttggtg
     2341 gacaggaaga acacgttgcc gtagccgccc gtgcagagca ggacggtatc ccctgcgtag
     2401 gatttgattt cgccggtaac cagattgcgg gtgacgatgc ccttggcttc gccgtccacc
     2461 agcaccagat ccatcatttc atggcgcgag aacatttcaa tgtgtccctt ggccacttcc
     2521 ttttccaggg cctggtaggc acccagcagg agctgctggc ccgtctgtcc gcgtgcgtag
     2581 aaggttcgct tgagctgggc gccaccgaag gagcggttgt ccagcaggcc gccgtattca
     2641 cggccgaagg gaacgccctg ggccacacac tggtcaatga tgttggagga gacttccgcc
     2701 agacggtaga cattggcttc acgggcgcgg aagtcgccgc ctttaacggt gtcgtaaaac
     2761 aggcggtaaa cggagtcgcc gtcgttctgg tagttcttgg ctgcgttaat gccgccctgg
     2821 gccgcaatgg agtgggcgcg gcgggggctg tcctggtagc agaagcattt gacgttgtag
     2881 ccaagttcgg caagcgtggc agcagcggag gcgccagcca ggccggaacc taccacaagc
     2941 accgtgtact tgcgcttgtt gttcggattg atcagtttgg actcaagctt gtacttggac
     3001 catttgtcct gaatagggcc ggagggaatt ttggcatccg gcatccagtc gcttacggga
     3061 aaattaatca tgactttgag aggagttgat ggttatttga tgatacccag aagaaccgag
     3121 accggcacgg agatgaagcc caggcagata atcgcgccgt aggcgatggc gataaagttg
     3181 tagaagggcc ggattttgcg ggaatcgacg cccacagtct ggaagatgga ctgtaccccg
     3241 tggcgcagat ggctgaacag catcagaacg gccaggatgt agaaggcgga gcaccatacg
     3301 ttggaaaatc cggtcacgat catcttgtac acgtcaaagg tttccaccgt accgtcggaa
     3361 atgaaggtgg tgaactgggc ggggtcgtat cctacgcgca gggtgtactg gtacaggtgg
     3421 tagatcagga acaccaggac ggtcagaccg gtatagatca tgtagcggga ggagagcgtt
     3481 gccttgatgg tgttcttgaa cacgtagggt tcgcgggccg catggttttc cagcttcagc
     3541 tggatggtca gccagacgtg gatgatgaag atcaccgcaa gccccgcgcg gattccccag
     3601 agggctgctt ccggcatgga gtgcaggccg tgggcgtagg tgttgatcca ttcagggcct
     3661 ccgaagatga gaaggttgcc tgccaggtgt cccgcaagga acaagaccaa acataacccc
     3721 gtcagagcca caatgatttt gcggccgatg gaggatgtca cgaatgtaca tatggttttt
     3781 actagtgcat tcataggcgc tctaatgaaa taaatgcgtc ttcacaggat gcccggttca
     3841 agcccggatg gcaagcctct tcttgaattt ccggcgcttt tcggattttt gaaaagccgg
     3901 ggaaagagat tgctgtttat cagtttggaa tggttatcat tttgttgcct gttccggctt
     3961 gacgaggctt tccgcatagg cgtatcgtct gtgcatgaaa agaagtaaaa aggaagtgct
     4021 ggacgcggat ttcgcagcgg cgcgcgccgg cgttctggat gtggccgcat ttctggaccg
     4081 ggtggaccgc ggggaagggg aggcggattt ccgttaccat gccctgatgg atgttcttcc
     4141 cctcttatcc gcatccggcc ccggacgcgt ccgggccatt ctggaagccc tttcctacag
     4201 ggatgacacc gtgccggaaa ccgccgcagc caaagcggcc tgcggagccc cgaacctcag
     4261 caaataagaa tgatggcttt catagaacct catatacata tggtgtgccg caccacggac
     4321 gaataccggg ccatggcgca ggccggctgc ctggcggtag gggaaccggc gttctgggcc
     4381 ggttacgacc gttcgtccgc ggacggtttc cgggattatt tcgtacagct tacggaatgc
     4441 gaacccgcca gggcggccaa gttcggcatg gaccattaca catggctgtg catcaatccc
     4501 aaggaggcgc aggacgtggc tttcgcgcgg gatgtaatga aactgattcc ggagttcatc
     4561 gaccggccca atgtcctcgg cattggggaa ataggactga accggaatac ttcccatgaa
     4621 atgactattt ttgaggagca tctggatctg gcggtgcgcc tcaaccagct tgtgctgatt
     4681 cacactcccc atctggaaga caagcttaag gggaccgtaa tgattctttc cgccctgaaa
     4741 aaccgtccgg atctggaccc ttgccgcgtg ctggtggatc actgtgagga acataccttc
     4801 ccgctggtga aggaggccgg ctactgggcc gggctgaccc tttatcccac cagcaagctg
     4861 aatcccaagc gggcggcgga tattctggaa ttgtacggaa tggaccgtgt ctgggccaat
     4921 tccgcggcgg actgggggga ttccgatccc ctggcgctga cggccttggc ctgcgagctg
     4981 cgcaggcgcg gtttttcccg gcaggaaacg gaacgtcttc tcctggaaaa tccggagaca
     5041 ttcatgggac agtccccgaa gttccggaaa gtgtcatccc gctaattccg cccgcggcgc
     5101 ggcggagggt acggccctct agtccccgtc cgggaaaaag acggtgagga cggcgcccag
     5161 gatgaccgcc gcgtcatcca gaaggcccag cctgccgatt ccgtcaaaca ggaattcgtc
     5221 gggagtcagg atgtaggcgc cggcggcggc cagaaggcat atattccgtt tgttgaaaaa
     5281 acgcggttct ccttttctgc ttttgaaata ccggaacagg cgcagtagca gctgctgttt
     5341 ttgaaggttc atggacggga acgggggata aaggttcaag ctcagccatt ttcccactcc
     5401 ttttccctgt ttcggggaag gagtctgttg ccgacggacg gaaaccgcag cgatccggac
     5461 cgtgcgggga aatggattgc tgaaaggatg ggctgttccg gatgctgagg gaagccgggc
     5521 tttgcatgct ccggttccgg ctgtcccggc atgggaaaaa ggggcgtgta cggaagtggg
     5581 gcggggccgg aagctcttga aatgaccctc ccgggggagc ctgaatgcca tttccccgtc
     5641 aagtgctggc cgtgagggta ccgcagcaaa tggaagcttc ttcccccctg ttttttccgg
     5701 cagatgtttg aacggataag gaaaaggccg gctcacgatt ttgtgagccg gcctttgaat
     5761 atagggaggc ggacggtaca ggcttatgcc ctgcggcggc gcatcatcag cgcggccagt
     5821 cccagcaggc ccagggaagc cgtggcgggt tccgggatgc tggcgatttc actcatcagt
     5881 tgaccaactt gttcctggga aaggagggag tcgtgaatgt agagctgttc gatggattca
     5941 gccagtcctg cgtccatgag aatctgatca atttgctggt tgccgaattt caggccgctg
     6001 ttggaatagt acgtagcgct gtctccaaaa tagatgcggg tgccaagatc tccggtgact
     6061 acggaaatgg tcagggaacc ttccgtgccc agcggggtgt caacgacggg cccgttgtat
     6121 gaggtgttgt tccataatcc ctggagtttc cggtccgtgt tcaggcccac gccccagctt
     6181 acactgctgt ttttggcgtt aaacagagcg gtataggtct ccggagtgtt gattttggac
     6241 aggtcaagaa ccatcgtcac agacataacg tcgcggttgt tggcaccgta tccgttgaag
     6301 gttatcccgg acaacgtcag attgctgtcg tcagacgtga tggaaacgga atctttccgg
     6361 gtgccgaaat ccgccgtttg ggaggcaaag tccgaatatc ccacgatgga gctatccaac
     6421 agagcggtag ccgcggtagc gcttaggctc atgccggccg aaagaatcag ggtggataat
     6481 aatttattca tggtcagtat cttaataaaa tgattcaagg ttcaatgtat gtacttgtgc
     6541 ttgaataacg aatttggaat ccgcaagcaa ttaaaaatat taagagttag tatattgtat
     6601 ttataattca ttgaaaataa tgatttttta atatctctgg tccttttgct aagatgacgg
     6661 gtcagtcttt gttattcatt ggtttcatga ttgatttggc ctctttttca ttacttgacg
     6721 gattccaaat tcgattgggg aattccaaat tcgctacaag ttgccatcca aaaggaataa
     6781 taaatatgaa gaaaacactg acatttttaa tcgcgatggg aagctttgct gtttcctcgg
     6841 aggcagcgac cgtttttaat tattacactc ccggtacgga taattacaat agtaccatcc
     6901 atgggtttta tcttggcctg gggtcttctt ccctggctcc ttccgattcc tcttctccct
     6961 cctccctgtc cggagagatc agactggaca gttttacgct gcgcggagcc gccaacaatt
     7021 tgggcgctaa tgtcacttac ggcttcctgg tgctgaatgg ctccgacaat tcggtcatcg
     7081 gctggagcac caatacggga actactgcag cagggattaa tctgacgttc agtttttctt
     7141 ccctggatgg ttctcccctg cttcttgacg cggcattgac ataccgtttc ctggccgtga
     7201 gccagtccgt gatggacttg atgcaggata cgtctaaaac gtatttatat gctgcggggg
     7261 gaacagccgc ccctactgct aacacggaag gagataccgt aacgatcagc ggcggattga
     7321 ctgctcccgg catccgcggc cattatgacg ccgagggagc gcctggtgat tctgtcgtta
     7381 ttacgggagc caacggaacc aatactttca gcttattatc cccgattttc acggaaatcc
     7441 gaggggaaat ggtgccggaa ccagccacgg tttccctggg cctgctggga ctggccgcgc
     7501 tgatgatgcg ccgacgcagg gcttgagctt cctgatggcg aaaaatcggc ggatgagagc
     7561 tgttcttgcg gaacagctct tgttttttat atccagagag gaagaattgc ttatccgtat
     7621 gcgggattca tgccctccgg aaggtacgga atttccgggg gcagggggcc gtatccggtt
     7681 ttttcggcat ggcggcaatt tgctggaaac gtttttgaga cgcagtaccg gaaagctttt
     7741 tctttaccgg aaaatgccgt caaattcggc agcgcgcttt tcgtccatat ggtacacggc
     7801 agctttcaca tagtggcctt tcaggccgga tagggaaccc ctttgcagct cacagacctg
     7861 gagggccgcc gcatacatat tattcgccgt cctattcccc ggcgctggta tttcggaaga
     7921 acggcaatgg gccccatgcc cagcacttca tattcttttc catcgtctgc cctgatgacg
     7981 gacgttgcat caacgatgtt tcccgacgat gcggctgccg tggacggcga ctgcatccag
     8041 ctccgggatg aaggacggac tgacgcgcat gatatggagc aggtaatgtt catggcagcc
     8101 ggggacgaaa tagttccaga acgcttctct cgtgacatgt tccgtttcgg catggtctga
     8161 ggattgttcc gttcttaatg caatggtcat gaaaggttgt tctttacggc tcccccttgg
     8221 agaaattcca gaggcggtgc atcgtcataa tgtccggaat gttcatgggg cgcaccacgc
     8281 ggaacccgat catgcctccg tccgtcaggt accagatgct tttagggttt tgaggatcct
     8341 gacggctcca ggcgggggtg ctggcgcggc gcgcagcgct tctcaggctg tccgggtcgt
     8401 cttcccacga accgccgcga acgatgtgag gggcgccggg gatgatgacc aaggggtctt
     8461 tcgcgggcan nnnnnnnnnc cgctccgttt gccgtaggca tccggaacgt aagagtccaa
     8521 aacccattcc gccacatttc cgtgcatgtc ccggagtccc cacttatttg gttttttaga
     8581 gcctgttttc tggtagcggt cattggagtt gttccagtac caggcgtact ggtccagaga
     8641 ggcttccccg tttccgtaag aataggcgcc gggggagccg gcccggcagg cgtattccca
     8701 ttccgcctcc gtgggcaggc ggtagtaatg cccggtctgg gcgctcagcc attcgcagaa
     8761 tttgctggcg gcgtggtggg acatggagat ggcgggcaga ccgtgttcat agccgtggcc
     8821 catgcccagg ttcatggcgg tgtagggggc ggtaggctgc gtaacggagt cccacagttc
     8881 gtcatccggc tgttcctcca gaagctggcc gtccttggcg cgcggacgcc cgttttccat
     8941 gaaggccgta taaagttccc aggggatttc cgtttccgag atccagaagg gggagatgct
     9001 cactttatgc tgcggacctt cgtccggttt ccggtgcggc tcttccgcgg gactccccat
     9061 gaggaacgtt cctcccggta tggcgaccat gcgcagggaa gctcccgcca cgggaaccgt
     9121 ttccgtgtag gattcaaaac gtgccggatt tccggaagct tcaatgagct gatggatttg
     9181 gcgcgttgtg ccgaccagct cccgggacgg caggtcatcc ggaatgggaa gggcaggacc
     9241 ggcagcgcgg tccagttccc gtttttgcag cgcggatcgg ctttctcccc actggcgtgc
     9301 gctggtaatg cgcgcggcat cttccgtggc cgggcggggg gaattatttt cttcccggca
     9361 cccggccagc agggcgcttc ctcccagaaa gcaggaaaca aggaaaatgc cgcgcatgga
     9421 atggagaaaa ccggaatgcc ctacatcgtc atgcctccgt cgcaggcaat gacctgcccg
     9481 gtgatgtaac gggcatcgtc agaggcaagg aaggccgtca gggcggcgat atcttccacg
     9541 gaaccttgtt ctttcaaagg tattttctta acgatttctt ccttgagatt gtcgggaatg
     9601 gaattggaca tttccgtgga gatgaagccg ggagcaatgg cgttgcacgt gactttgcgc
     9661 ggagcgaatt cctgagccag tgatttggtg aaaccgatga gacccgcctt ggaagcggcg
     9721 taattggcct ggccgatgtt gccgacgaga ccgatgacgg agctcatgtt gatgatgcgc
     9781 ccggccgggg atttcatgag aacgcgctgg agggccttga ccgtattgaa cgcgcttttc
     9841 aggttggtgt ccagaacagc atcccagtct tcctctttca tgcggagcat cagggagtcc
     9901 cgcgtgatgc cggcgttgtt caccaggatg tcaatctgcg ggaagtcttt caaaatggcg
     9961 gccatggttt cctgaacggc cgcgtaatcc gctacgtcgc aggggtaggc cttgcaggaa
    10021 tccggaaatt ccttgttgat ttcttctgcg gcccccccgc agctggatgg actgcggctg
    10081 atcaggatga ccctggctcc ttccgaagcg aagcggcgcg cgacggcatt gccgattccg
    10141 cggcccgcgc cggtaacgat ggctgtttta cctgctaact tttgcatgct gcccacagta
    10201 aacccgtttt tcacggttcc ggcaagcttg aaatggactt ggccgcgcag gaacccatac
    10261 ggggaagggg cgtgccggga atgaaaaaag agggggggag aaacggggcg gggggctact
    10321 gtccggcctc ttcattttcc cggagtgcac cggggggcgt cccgtcttca tccggttcta
    10381 ccaggtcgct gaattcatcc gaattttcca aaatgtcctt taaggcggcg gaaccgtaat
    10441 agcgggcctc aaacaggcgt ttgccttcct gcctgcagcg gttgtccagc atttccattc
    10501 gtttttccat tttttctatc aaggcgtctt ctttctcctt ttccgcatcg ttcaatttat
    10561 cctgaagctg gaggaaatgc cggatgtcct tctgaatgtc ctgcagcgtt ttgacggcgt
    10621 tgtccgcgct ttccttgtcc tgaacgcctg ccaacgtctg ctggatattg atggcaaagg
    10681 aaaaggcctg gttgatcagg gattccgcgg aaggaatttt ttccgccgga gccgctgctg
    10741 cgggggaagc cgttccggcg gccgtttcac caaatgcaag agaggctccg gacagaagcg
    10801 cagaatataa gagaggaaca agaaaagcct tcatcctgtt cttttaaggc aggatgaaat
    10861 ccacggcaag gaaaaagggg aaactgaaaa aagagcctta ttccgccgtg atgccgcctt
    10921 tttcatcgtc cagaatgcct gacttttcca gatagtagtc atatccacct gcgtaggcgg
    10981 tgatggtccc ccggttcaca tgcagggttt tttgtgccag ggaacggatg aagtgcacat
    11041 cgtgggagat gaagaccagt gttccttcat aatgcttcag agcctgcacc agggcttcta
    11101 cggacaaaag gtccaggtgg gtggtcggct cgtccatcag caggaggttg ggcggatcca
    11161 ccaggaattt gaccaggctg agccgcgatt tttccccgcc ggaaagaacg ctgacgcgtt
    11221 tttccacatc cagcctccgg aacaggaagg aacccaggat ggaacgcgct tcttcctccc
    11281 ggatttcagc gctgcatttc atgatttcct ccagcacggt attttccgga ttcaggtttt
    11341 ccgttcgcgc ctgggagaag tagccgatgc gcgtcgtggt accgggagtg cgttgtccgg
    11401 agtcaatggg gatgatgccc gccaggattt tgagaagagt ggatttgccc gcgccgttcg
    11461 ggcctacaag aacagtgcgc tccccgcgtt ccaccagcag gtccaggttt tcataaaccc
    11521 tgcggtcgcc ataggattgg cagacttttt ccagctcaat gactttctgg gtgctgcgcg
    11581 gaggctgggg gaagttgaat ttaaatactt tcctgcgggc taccggtttt tgaatgattt
    11641 tcatcttttc cagctgcttg atgcggctct ggacttgccc ggctttggaa ttgatggagc
    11701 ggaaacggtc aataaattcc tgaatgtgcg ctatttcctt ctgctggttg cggtaggccg
    11761 cctgaagctg ctcgaagcgc acgtcctttt gttggaggaa gtccgagtaa ttgccgcggt
    11821 attccaccag ttcttcgttg tcgatgtcgt acacgctttc caccagctca tccatgaaat
    11881 cccggtcgtg ggaaatcatc aggatggctc cggggtagtt tttcaggtat cgctggagcc
    11941 acagcaggga caggaggtcc aggtggttgg taggttcgtc cagcatcagg aggtccggct
    12001 ccaggacaag gagcttggcc aggtacgcgc gcatgatcca gccgccggac atttcccggg
    12061 cggggcgatg gaagtcgctt tcccgaaagg ccagcccttt gagaattttc ttggctttgg
    12121 gctccagctg gtaaccgttg gcggcgttga aagtgtcaat ggcttccgcg tattccggcg
    12181 tatccgtttt gttggcgttt tccgccgtcc ggatggtgtg gatggcctgt tccatttccg
    12241 gcgtgatgcc cagggcgatt tccagaacgg tttcatcctt cggttcgctg gcttcctggg
    12301 gaagatagcc cacgatggcg tattcatcca tgctgatgga gccttcgtcc ggcgtgtctt
    12361 ctcccagaat catgcggaac agggtggatt tgcctgctcc gttggggcca accagagcca
    12421 cccgttcccc ccagttaatg gtcatttccg tttccctgaa caaggtccgt ccggcgtggg
    12481 attttgtgag atttttgatc gtcagcatgg tgaagagagg atgtattcta ccgggatgga
    12541 aaggggaagg caagagccgt cagggcggag gcaggcattt ttgaaagctt tactggattt
    12601 ttacgcgtag tctgctagcc ttggcgcgcc atgccgacca cgcagacatt caggcttttg
    12661 cttgctgccg cccttttgtg cggatggagt tcctgctgta ctcctccggc ggaggattat
    12721 atacaacaac cttacgtgca gcagcaaatg tccgggctgg ctaatgcctt cctggcgctg
    12781 ctgccgccgg atcaggcctc tcttcccgct gccggagcgg aggccaggtg gctggcggac
    12841 acggccgtgg tccagtccgc agcgattgcc cgggacaaca ggactgtgct gtttggctgg
    12901 ctgaacaata ttctggtcaa ttccaacctg cgcgacaggg ggctgtgctg gcaggtccag
    12961 caggatttgt accgggacct gcgccgccgc cccgtgaagt atttccgcat agggctgacg
    13021 attcgagacc gtggaacggg cagggagcac agttgcgtgt atgtcaatgc cgcggggaag
    13081 ggattgcagg gctccattgt tctggatgcc tggaagaact gcgggcatct ggtgacgctg
    13141 acccagaagg accgggaagg cggcaaatgg gaggaggact ggcgggaacc atttgtttcc
    13201 aaggcctttc cggagggcca ttcctacggc atggaacatc acctggtctg gcccgggtgg
    13261 gccaggaaac gccccatgct ggttcagcgg atattccagt ccgatcagca gaatgaggcg
    13321 aaggcggccg ctgaataaag gggaagcctg atccggcagg aaccggcaca cggtgctgcg
    13381 ccgcggcggt ttgcggtatc cgccgttttt aaggaaaatc ccggcgaatc ggcaaatggc
    13441 ggagggaatc cggactcagg gcaaataaaa acgcactcag tgcgtacacc gagtgcggat
    13501 taattggata atttgctagt gttgcagggc aaaaccccgc tgcaaactta cttgcccttg
    13561 gcctgcacaa ccggagcggg agcaggagcg gtggtttgct gttgctgctg ctgctgggag
    13621 caagaagcga ccaggcaagc ggcgccggcg atggcgagga tagcgatgtt cttcataatt
    13681 cgaattaaat acagtgtttg ttaactactg gaacctccgc atccacggag gtttgctggc
    13741 accaatgtaa atggtggcaa gtagaaatca agagattttc ttgttccatg tcac
//
