LOCUS       c00042_gnlPro..        14119 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IEPJPLPJ_42.
ACCESSION   c00042_gnlPro..
VERSION     c00042_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 07:05:06
            Original ID  :: gnl|Prokka|IEPJPLPJ_42
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14119
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14119
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2835:12836]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2836..12836
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14119
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14119
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             2..214
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 61.6; E-value:
                     1.6e-19)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_1"
                     /sec_met_domain="Biotin_lipoyl (E-value: 3.4e-20, bitscore:
                     61.6, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="AGDVPSPLAGKVVSLDVAAGAPVKAGDQILTLEAMKMNTIIYAPA
                     SGTLTAFCVNPGDTVQEGQALAKIG"
     CDS             332..1957
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) OAD_beta"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_2"
                     /sec_met_domain="OAD_beta (E-value: 1.5e-159, bitscore:
                     520.3, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGVFSLSWQMVGMWGIAILLLYLGVAKQYEPLLMVPIAFGALIAN
                     IPDNGMLITQLNQQVISSNEQGEVTATSLNNVGYLRVHVAPLQQAPSKVPANLTTPESR
                     AQYQEIMQQPMQVYPGSQLTVSKIKSVRESQEKAKADAARLGDDSLTVDPNLKDFQNVT
                     EDNGNEPVFLLTNGEGTTVVRQQGVNYFDTSGNRIPVDLKTQKLEPLVVSAAGKYVAVG
                     QHTQELLVTSIHGGLYDWIGLGIKAEIFPPIIFLGVGALTDFGPLLAAPRTLLLGAAAQ
                     VGVAATFFMALFMGFTPNESASIGIIGGADGPTSIFLTMKLAPHLLGAVAVAAYTYMSL
                     VPLIQPPIMALLTTKKERLIRMKSLRTVSKSEKLFFAVLVTIVTILLIPDASPLIGMLM
                     LGNFLRECKVTERLVQASQNEIINIVTIFLGTSVGLTMQGDRFLQSETLLIILLGIVAF
                     GVATAGGVIAAKIMNLIWRKNPVNPLIGSAGVSAVPMAARVSHNVGQKYDPSNYLLMHA
                     MGPNVAGVIGTAVIAGYYIATLAK"
     CDS             1995..2774
                     /locus_tag="ctg42_3"
                     /transl_table=11
                     /translation="MNSAASFSTPPEEEGPCGDWTYHEWAEAFSTNDLARALPPGHIAV
                     CRVQTGGRGRFNRKWIGEEGGLWASFTVPLSAPEDTAAGVHWGHLPLVAGLALFNMLRG
                     MGLDSVRLRWPNDLLAGKSKLAGILVERPAENMAVIGIGINVFNDVSSIAGEIKDPPAR
                     LADLVRGCPSLHAVMASLGSHLNQVLSVFSHGGVPALQEGLSRAWAGKRPVSILTDDET
                     IRGIFTGIDDQGNPVLSLPAGTVRTIPAHLINRLLEE"
     CDS             2836..4332
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hydro"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: AcetylCoA_hyd_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_4"
                     /sec_met_domain="AcetylCoA_hyd_C (E-value: 7.3e-47,
                     bitscore: 148.9, seeds: 181, tool: rule-based-clusters)"
                     /sec_met_domain="AcetylCoA_hydro (E-value: 5.1e-44,
                     bitscore: 140.4, seeds: 5, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSYKVLTPEEAASLIKHGHHIGLSGFTPAGTAKAVTAALAKIAEA
                     EHEKGNPFQVSVFTGASTGDSCDGILSRAKAIRYRAPYTTNVDFRKAVNNGEIAYNDIH
                     LSQMAQEVRYGFMGNVDIAIIEACEVTADGKIYLTAAGGIAPTICRLADKIIVELNGAH
                     SKSAMGLHDVYEPLDPPYRREISIFKPSDRIGKPYIQVDPKKIVGVVETNWPDEARSFA
                     AADPLTDKIGQNVADFLAADMKRGIIPSTFLPLQSGVGNIANAVLGALGRDKTIPAFEM
                     YTEVIQNSVIGLIREGRVKFGSACSLTVTNDCLEGIYRDMDFFRDKLVLRPSEISNSPE
                     VIRRLGVISINTAIEADIYGNVNSTHIGGTKMMNGIGGSGDFTRNAYISIFTCPSVAKD
                     GKISAIVPMVSHHDHTEHDVNIIITEQGVADLRGKSPKERAQTIIENCVHPDYKNILWD
                     YLKLSDGKAQTPQSIRAALGMHAELARSGDMKNVDWAQYK"
     CDS             4451..5152
                     /locus_tag="ctg42_5"
                     /transl_table=11
                     /translation="MNWMIYPAARAFIKVCAVLFGTGAAAAVLIHLFMPFFLRSPRTAA
                     PFLLLGTGAELLSILSLSFLMFWGARVLLASRGSRITRNLSMLAFLPALYALLIPFAGI
                     PVPSQYTEMDRVWEAFLLLAAVISFFSFPYTAGYEAAGRRLFLAWGIAAAGCGLQSALF
                     FLAVLLRQFLSTAVPSLAAPVAWLAVLLSCGLEIMLATLSAILAQRLFKEVMSIASMPE
                     PIDPSMPGNRP"
     CDS             complement(5356..6219)
                     /locus_tag="ctg42_6"
                     /transl_table=11
                     /translation="MKGIVLAGGSGTRLHPVTLSVSKQLLPVYDKPMVYYPISVLMLAG
                     IREILVISTPRDLPLYRDLLGDGSRFGVSFEYREQPRPEGLAQAFIIGEEFIGKDSVAL
                     VLGDNIFYGRGLTEKLRRAAELTSGATIFGYQVHDPQRFGVVEFNEEGKAVSIEEKPLR
                     PKSDIAVTGLYFYDNRVVEIAKRIPKSSRGELEITSVNQEYLKQGLLRVEKLARGYTWL
                     DTGTHDTLLEASMFVRTLEHHQGFKVACLEEIAFNNGWISQETLRSQAGAMNNNGYGRY
                     LDELVK"
     CDS             complement(6229..7281)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GDP_Man_Dehyd"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg42_7"
                     /sec_met_domain="GDP_Man_Dehyd (E-value: 3.9e-99, bitscore:
                     321.9, seeds: 258, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVIVTGGAGFIGSNLVRLLLERGHEVLNIDALTYAGNIHSLDGS
                     ADSPAYRFLHADVRDASLMRRTLREYAPDWVMHLAAESHVDRSIDDPGNFMTTNVMGTF
                     SMLQAALEYYRSLEGEKKERFRFHHISTDEVYGSLGKEGLFTESTPYRPHSPYSASKAS
                     SDHLVRAWHDTYGLPVLITNCSNNYGPYQFPEKLIPVVILKALGGEPIPVYGKGENVRD
                     WLYVGDHCEALLTVVSCGKPGETYNIGGNNEKTNLELVELLCSHLDELRPRPDGRSYRE
                     QISFVQDRPGHDLRYAIDASKIRRELGWTPHQDHSSGFRKTIQWYLDHEEWWRGILSGE
                     YRLERLGTNG"
     CDS             complement(7413..8357)
                     /locus_tag="ctg42_8"
                     /transl_table=11
                     /translation="MTSGGDAAGMNPAIKAAVDHARQLGMNPYVVYDGLEGLIDGKIKE
                     ATRELTNDMIYRGGTLLRSSRSKRFFDYEFRKQAYEHLKERNIDKLIIMGGDGSFRALN
                     DFFNDFEVPFAGIPATIDNDIAGTDYCLGVDTAQNVILDCIDSVRDTARSHHRAFVIET
                     MGRDCGYLAMTTALCSAADICIVPEIPYDLESIYKRLQPVINEEGSCIIAVVAEGTRVA
                     QYLTRWLTERAGMDTRLTVLGHVQRGGSPTARDRLMGTRFATRAVEALNNGDINQIMVY
                     HDGQYGYASLDSVAGQQYSVNQDIINLCRELSC"
     CDS             8486..9217
                     /locus_tag="ctg42_9"
                     /transl_table=11
                     /translation="MNDTAAAILKATAALRDGTEKLRFESPVHVTYNPLTYAWGPHEQY
                     VRTYGNGEKGHLFLGMNPGPFGMAQTGVPFGEVDAVVNWLHIRGEVGRPEHTHPKRPVE
                     GFGCPRSEVSGRRLWGLFAEAFGTAENFFRHNYVANYCPLIWMGATGANITPDKLPAEQ
                     RAAVDAVCMEHLLSLITILNPHTLVGVGAYATQKLRDAASRLPRKSFTIGTLLHPSPAS
                     PIANKLWPERPIQQLKELGIL"
     CDS             9334..9489
                     /locus_tag="ctg42_10"
                     /transl_table=11
                     /translation="MSGPLYWLDLPRDTAFLTEEMHAGIYRNREELKRLPTSTTKSASL
                     QINHHS"
     CDS             9585..11051
                     /locus_tag="ctg42_11"
                     /transl_table=11
                     /translation="MAISDYIVTIGLEVHCQIKTKSKMFCSCETGFGFEPNTRVCPTCL
                     GLPGALPVLNEFAIERTLLTGLMLGCSSPEISQWDRKNYFYPDMAKNYQTSQLDLPLCL
                     GGEVPLYPWSYPNDVIKAGVPPFRTVKLTRIHLEEDAAKITHHANYSLIDYNRAGSALM
                     EIVSEPDIDTPEEAYAYLKSLQQILNYGDISDADMEKGQMRCDVNISLRPHGQKELGAK
                     VEMKNINSMSAVRRALHYEIQRQAEELDMGIPQIQSTRRWDDERGESVVMRTKEDAHDY
                     RYFPCPDLVPVRTAPLVEKVRGQIPELPQERQKRFMEEYGLSEYDANVLVGDLELARFF
                     EEAARGTASGKKIANWVINNISAVLNGKGMRPSECPVKPGAIRELIAIIDDGTVSNNQA
                     KDVFAKMWDEPALAAAQAAKLLGFEKADSSFLDGIVREVISANPDKVAEIQGGNEKLLN
                     WLTGQVMKAAKGKANPKIVTEALKKALSME"
     CDS             complement(11106..12836)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg42_12"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.3e-34, bitscore:
                     108.2, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYRVADQIVEILEKAGVKRIYGIVGDSLNPVTDALRRRKTIEWIH
                     VRHEEVAAFAASAEAQLSGNLAVCCGSSGPGNLHLINGLFDAHRNHAPVLAIASHIPQS
                     QVGMEYFQATHPEQLFKECSAYAELVSEASQAPSILMSAIQHAWARRDVGVVVLPGDIA
                     DAPAEMKNLVHPPSYTRENVVPEHESVSLLARMLDDHRRITFFCGAGCAGAEDRVVRLA
                     HRLKAPIAYTWRGKDYFEHDNPLGIGMTGLLGWGDAYKAMHESDMLVLWGTDFPYFNFI
                     PTKPEIVQIDRRGEVLGRRCRLDLGICGDVSVTAEALLNMVQEKTDSGHLDAALKRHAR
                     DVKEMNAYMEGNDKESPIRPEQLTTALNRHAASDAVFTVDTGTPCIWSARFLCATPGRR
                     TLASFNHGSMANAMPMAIGAQMEYPERQVIALCGDGGLSMLLGDLITIVQYRLPVKIVV
                     YNNDCLDFIQLEMQAAGLIPWQINLNNPSFAAVADAVGIKGFLLDKSSQVDQMVDMFLN
                     YPGAALLDAHVDRDALALPPYISMGQAADFSLAMMKQTLAGEVKQVWNTLAGNRKLFKP
                     "
     CDS             complement(13002..13730)
                     /locus_tag="ctg42_13"
                     /transl_table=11
                     /translation="MAIAACCSVPALASPGSLEPSDGTSYVAGTATTTEGIALGKDMTF
                     GSLSQSALPGSFIPYGGNFYASNYTISLWLDASSLTEGTQTTLFGYYGTNAGQSYGANA
                     LYLTSDAKFGMGDGNLNTSTGSFSQNRGDVSETPVVLGGGLLNVTLAVTGANQSQSVEV
                     YVNGSLLDTLSYNGNMNGNRTDIQSWINPNLTWGEIQWTDTKLSAEQIAGFAGLQVPEP
                     ASASLGILGLAVLMMRRRRS"
ORIGIN
        1 cgcaggagac gttcccagcc cgcttgccgg gaaggtcgtc tccctggacg tggcagcagg
       61 cgctcccgtg aaggccggtg accagattct gacgctggaa gccatgaaga tgaacaccat
      121 catctacgct cccgcctccg gcacgctcac cgctttctgc gtgaacccgg gcgacacggt
      181 tcaggaaggt caggcactgg ccaaaattgg ttaatcccgg cggcggcagc ccggaaacgc
      241 caacagtccc gggctccggc tcagataata aaccgctaca aaaatattcc ctatgagtct
      301 ttttgattca ttaatcacct ttttacaggg gatgggcgtc ttctccctat catggcagat
      361 ggtagggatg tggggcattg ccattctcct cctgtatctg ggtgtagcca agcaatacga
      421 accgctcctg atggttccca ttgctttcgg cgccctcatt gccaacattc cggataacgg
      481 aatgctcatc acccagctga accagcaagt catctcctcc aatgaacagg gggaagtaac
      541 cgccacgtct ctgaacaacg tggggtacct gcgcgttcac gtggctccgc ttcagcaggc
      601 tccctccaag gtgccggcca acctgaccac gcctgaatcc cgtgcccagt atcaggaaat
      661 catgcagcag cccatgcagg tttaccccgg cagccagctg accgtttcca agatcaagtc
      721 cgtgcgggaa tcccaggaaa aagccaaggc tgacgcggcc cgcctgggcg acgacagcct
      781 gacggtggac cccaacctga aagattttca gaacgtgacg gaggacaacg gcaatgaacc
      841 ggtcttcctg ctcacgaacg gagaagggac caccgtcgtc cgccagcagg gcgtcaatta
      901 ctttgacacc agcggcaacc ggattccggt ggatctgaaa acccagaagc tggagcccct
      961 ggtggtttca gccgcaggca aatacgtggc cgtaggccag catacccagg aactgctggt
     1021 cacctccatc cacgggggcc tgtatgactg gatcgggctg ggcatcaagg ctgaaatttt
     1081 cccgcccatc atctttctgg gcgtaggagc cctgacggac ttcggcccgc tgcttgccgc
     1141 tccgcgcacc ctgcttctgg gcgcagcggc ccaggtgggc gtagccgcca cgttcttcat
     1201 ggccctgttc atggggttca ccccgaatga atccgcgtcc atcggcatca ttggcggcgc
     1261 tgacggcccc acctccatct tcctgacgat gaagctggcc ccgcacctgc tgggcgccgt
     1321 ggccgtggcc gcatacacgt acatgtccct ggttccgctg atacagccgc ccatcatggc
     1381 gttgctgacg accaagaagg aacgcctcat ccgcatgaaa tccctgcgaa cggtcagcaa
     1441 gagcgaaaaa ctatttttcg ccgtgctggt aaccattgtc accattttgc tgattccgga
     1501 cgcatccccg ctgatcggca tgctgatgct tggcaacttc ctgcgcgaat gcaaggtgac
     1561 ggaacgcctg gttcaggcct cccagaatga aatcatcaac atcgtcacca tcttcctggg
     1621 aacctccgtg gggctcacga tgcagggcga ccgcttcctg cagtcggaaa cgctgctgat
     1681 catccttctg ggtatcgtcg ccttcggcgt ggcaacagcg ggtggagtga ttgccgccaa
     1741 gattatgaac ctcatctggc gcaagaatcc ggtcaacccc ctgatcgggt ccgcaggcgt
     1801 ctccgccgtc ccgatggcag cccgcgtctc ccacaatgtg ggccagaagt acgacccctc
     1861 caactacctg ctcatgcacg ccatgggtcc gaacgttgca ggcgtgatcg gcaccgcagt
     1921 catcgcgggt tactacatcg ccactctggc gaaataacca gaattgaaaa ttactcccgg
     1981 cctcggcccg tcccatgaat tccgcagcct cattttccac ccctccggag gaggaaggac
     2041 catgcggcga ctggacttat catgaatggg ccgaggcttt ttccaccaat gatctggccc
     2101 gagccctccc cccggggcat attgccgtct gccgcgttca gacaggaggc cgcggcaggt
     2161 tcaaccgcaa atggataggg gaggaaggcg gcctgtgggc atccttcacc gtccccctgt
     2221 ccgctcctga ggatacagcg gccggcgtgc actggggaca tttgcccctg gttgcggggc
     2281 tggccctgtt caacatgctc cgcggcatgg ggctggattc cgtgcgcctg cgctggccga
     2341 acgacctgct ggcgggcaaa tccaaactgg cgggaatact ggtggaacgc ccggcggaga
     2401 acatggccgt catcggcatc ggcatcaatg ttttcaatga tgtatcctcc atcgccgggg
     2461 aaatcaagga ccctccggca aggctggcgg atcttgttcg gggctgccct tccctgcacg
     2521 ccgtcatggc ttccctgggc agtcatttga accaggtcct ttccgtcttt tcccacggcg
     2581 gcgtccccgc ccttcaggag gggctgtccc gggcatgggc cggaaaaagg ccggtttcca
     2641 ttcttacaga tgacgaaacc atccggggca tttttacagg gattgacgat cagggcaatc
     2701 ctgtgctatc ccttccggcc ggcaccgtcc gcaccattcc ggcgcacctg atcaacaggc
     2761 tcctcgaaga atgagcctgc cgctccgttt ttacacgggg tttctttctt ttttcatcca
     2821 acaaaaatca ctgacatgag ttacaaggta ctgacaccag aagaagcagc aagcctgatc
     2881 aagcatggcc atcatattgg cctgagcgga ttcacgcccg ccggaacggc caaggccgtt
     2941 acggctgcgc tggcaaaaat cgcagaagcg gaacatgaga aggggaaccc tttccaggtg
     3001 agcgtcttca ccggtgcttc caccggcgat tcctgcgacg ggatcctttc ccgggccaag
     3061 gcaatccgct accgcgctcc ctacaccacc aacgttgatt tccgcaaggc ggtgaacaac
     3121 ggggaaatcg cctataatga catccatttg tcccagatgg cccaggaagt gcgctacggg
     3181 ttcatgggca acgtggacat cgccattatt gaagcctgtg aagtcacggc cgacggcaaa
     3241 atttacctga cggccgcggg cgggatcgct cccaccatct gccgcctggc agacaaaatt
     3301 atcgtggaat taaacggcgc ccacagcaag agcgccatgg gcctgcacga cgtttacgaa
     3361 cccctggatc ctccctaccg ccgcgaaatt tccatcttca aacccagcga ccgcatcggc
     3421 aagccgtaca tccaggttga cccgaaaaag attgtgggcg ttgtggaaac caactggccg
     3481 gatgaagccc gttccttcgc cgcagcggat cccctgaccg ataaaatcgg gcagaacgtg
     3541 gccgatttcc tggctgccga catgaaacgg ggcatcattc cctccacgtt cctgcctctc
     3601 cagtccggcg tgggcaacat cgcaaacgcg gtgctgggcg ccctgggccg cgacaagacg
     3661 attcccgcgt tcgagatgta cacggaagtc atccagaatt ccgtcatcgg cctgattcgg
     3721 gaaggccgcg tgaaattcgg cagcgcctgc tccctgaccg tgacgaacga ctgcctggaa
     3781 ggcatttaca gggatatgga ctttttccgc gacaaactgg tgctccgtcc ctcggaaata
     3841 tccaacagcc cggaagttat ccgccgtctc ggcgtcatct ccatcaacac cgccattgaa
     3901 gccgacattt acgggaacgt caactccacg cacattggcg gcacgaagat gatgaacggc
     3961 atcggcgggt ccggcgactt cacgcgcaac gcctacatct ccattttcac ctgcccgtcc
     4021 gttgccaagg acggcaagat cagcgccatc gtccccatgg tttcccacca tgaccatacg
     4081 gaacatgacg tcaatatcat tattaccgag cagggggtcg cggacctgcg cggcaagagc
     4141 ccgaaagaac gggcccagac cattattgaa aactgcgtcc acccggatta caaaaacatc
     4201 ctctgggatt acctgaagct gtccgacggc aaagcccaga caccgcaatc catcagggcc
     4261 gctttgggca tgcacgccga actggccaga agcggagaca tgaagaatgt cgactgggcc
     4321 cagtataagt aattccgcat gccgtcattc gcattggcat ccatgaattc acgctaaccc
     4381 ctcaggaccg cttccgcaaa gggagcggtc cttttccttt ttcccatccc ctctactcct
     4441 tctcttcacc atgaactgga tgatttaccc ggcagccagg gctttcatca aagtctgcgc
     4501 cgttcttttc ggcacgggcg cagcagcggc agtcctcatc catctgttca tgcctttttt
     4561 cctccgctct ccccggacag ccgcgccctt cctgcttttg ggaacagggg cggaactgct
     4621 ttccatcctt tccctgtcct tcctcatgtt ctggggcgcc agagtcctgc tggcctcccg
     4681 cggaagcaga ataacaagaa atctgagcat gctggccttc ctgcccgccc tgtacgccct
     4741 cctcattccg tttgcgggca tacccgtccc atcgcaatat acggaaatgg acagggtttg
     4801 ggaggccttc ctccttctgg cggccgtcat ttctttcttt tccttccctt atacggcggg
     4861 atacgaagcc gcaggcagga gattattcct ggcctggggc atcgcagcgg caggctgcgg
     4921 tttgcagagc gccctgtttt ttcttgccgt cctgttgcgt cagttcctgt ccaccgcagt
     4981 tccctccctg gcagcgcctg ttgcatggct ggccgttctt ctgtcctgcg gcctggaaat
     5041 catgctggcg accctttccg ctattctggc gcagcgcctg tttaaagagg tcatgtccat
     5101 agcatccatg ccggaaccga ttgatccttc catgccgggc aaccgtccct gactttcctc
     5161 ccctccgttt ttaccggcct gccggaagag caccctcatt ccccggcatg aaaggctttt
     5221 acggctttgc gcaaaaagcc gtccggaaat ttccgccggt ggaacggaat ccgtatggaa
     5281 agcaacccgc cccaccccgg aaagccgcgg gttcgcaggc cccccctccc gtttccacgc
     5341 cgacggcaga cagccctatt tcaccaattc atccagataa cggccataac cgttattatt
     5401 catggctccg gcctgggagc gcagcgtttc ctgggaaatc cagccgttat taaaggctat
     5461 ctcctccagg caggctacct tgaacccctg gtgatgctcc agagtacgaa cgaacatgga
     5521 agcctccaga agggtatcgt gcgtgcccgt atccagccac gtatagccgc gcgccagttt
     5581 ttccacgcgc aacaggccct gcttcaggta ttcctgattc acagaggtga tttccaactc
     5641 gccgcgggaa gacttgggaa tccgtttggc aatctccacc acccggttgt cgtaaaaata
     5701 gaggcccgtc accgcaatat ccgatttggg cctgagcggt ttttcctcaa tggaaaccgc
     5761 cttcccctcc tcattgaatt ccactacccc gaaacgctgc gggtcatgca cctggtaacc
     5821 gaaaatggtc gctccgctcg tcagttcggc ggccctcctc agcttctccg tcaggccgcg
     5881 cccgtaaaaa atattgtccc ccagcaccag ggcaacggaa tcctttccta tgaactcctc
     5941 tccaataata aaggcctgag ccagcccctc cggcctgggt tgttccctgt attcaaagga
     6001 aacgccgaac ctgctgccgt cccccagcaa atcccggtac aggggcagat cccggggcgt
     6061 ggaaataaca aggatttccc gtattccggc cagcatcagc acggagatgg gataataaac
     6121 catcggctta tcgtaaacgg gcagcaattg cttgctgacg gaaagcgtaa cgggatgcag
     6181 acgcgtgccg cttcccccgg ccagaacaat acccttcata tcaaattcct agccattggt
     6241 tccaagacgt tccaggcggt attccccgga caggatgccc cgccaccatt cctcatggtc
     6301 cagataccac tgaatggtct ttctgaatcc ggaagaatgg tcctggtgcg gagtccaccc
     6361 caattccctc cgtattttgg aagcgtcaat cgcatagcgc aggtcatggc ctggcctgtc
     6421 ctgcacaaag gagatttgct cccggtagct ccggccgtcc ggacggggcc gcagttcatc
     6481 cagatgggaa cacagcagct ccaccagctc cagattggtt ttctcgttat tgccgccgat
     6541 gttgtacgtt tcccccggtt ttccgcagga aacgaccgtc aacagcgcct cgcagtgatc
     6601 ccccacatac agccagtccc gcacgttttc ccctttgccg tatacaggaa tgggttcccc
     6661 gcccagcgct ttcaggataa cgacgggtat cagcttttcc gggaactggt aggggccgta
     6721 attgttggaa cagttggtga tcagcacggg cagtccgtac gtatcgtgcc aggcgcgcac
     6781 caggtggtcg ctggaggcct tgctggcgga atacggggaa tgggggcgat acggcgtgga
     6841 ctccgtgaac aggccttcct ttcccaggga gccgtacact tcatccgtgg aaatgtgatg
     6901 aaagcggaaa cgctcctttt tctctccctc cagggaacgg taatattcca gggcggcctg
     6961 aagcatggaa aaagtgccca tgacgttggt ggtcataaaa tttcccggat cgtcaatgga
     7021 acggtccaca tgggattccg ccgccaggtg catcacccag tccggagcgt actcccgcaa
     7081 agtgcgccgc atcagggaag cgtcccggac gtcggcgtgc agaaagcggt atgccggaga
     7141 atccgccgag ccatccagtg aatggatgtt gccggcatag gtcagggcgt caatattcag
     7201 gacttcatgg ccgcgctcca gcagcagcct gaccagattg gagccgatga atccggcgcc
     7261 gcccgtaacg ataactttca tagcactgtt ttcagggaaa gatgcggcgc catcatacag
     7321 cagcggcgtt ttttttcaaa acaaatccgc ccatgccgcg ggaacgtggc ggcatgggcg
     7381 ggaaaaagcg ggttccgtaa ccgctgagac ggctagcagc tcagctcccg gcaaaggttg
     7441 atgatatcct ggttcacgga gtactgctgc ccggcaacgg aatccaggga ggcatagccg
     7501 tactggccgt catgatacac catgatctgg ttgatgtccc cgttgttcag agcttccacg
     7561 gcgcgggtgg caaaacgggt gcccatcagg cggtcacggg cggtggggga accgccgcgc
     7621 tgcacatggc ccagcacggt caggcgggta tccatgccgg cgcgttccgt cagccagcgg
     7681 gtcaggtact gcgccacgcg ggtgccttcc gccaccacgg caatgatgca gcttccttcc
     7741 tcattgatga caggctggag gcgcttgtaa atggattcca gatcatacgg aatttcagga
     7801 acaatgcaga tatccgccgc gctgcaaaga gcggtggtca tcgccagata gccgcagtcc
     7861 cggcccatcg tttcaatcac gaaagcgcgg tgatgggaac gggccgtatc acgaacggaa
     7921 tcaatgcaat ccagaatcac gttctgggcc gtatccacgc ccaggcagta gtccgtgccg
     7981 gcaatgtcgt tgtcaatcgt agccgggata ccggcaaaag gcacttcaaa atcattgaaa
     8041 aagtcgttca gggcgcggaa ggaaccgtcc ccgcccatga tgatgagctt gtcgatgttg
     8101 cgttccttca gatgctcgta ggcctgcttg cggaattcgt agtcgaaaaa gcgcttggat
     8161 cgtgaggaac ggaggagagt tccgcccctg tagatcatat cgttggtcag ttcccgggtg
     8221 gcttccttga tttttccatc aatcagccct tccaagccgt cataaacaac gtacgggttc
     8281 atcccaagct ggcgggcatg atccactgcc gccttgatcg ccgggttcat tccggcggca
     8341 tcaccgccag atgtcataat ggctattcca ctcataagta ataaggttaa cttgtccggg
     8401 gggaaatgtt accgggcgga acaaataatg caagcgcgga gtttttactg gcgcaataaa
     8461 cggcaacgct tcatgatgcg gaggcatgaa cgacactgca gcagccattc tgaaagccac
     8521 ggccgccctc cgggacggca cggagaagct ccggttcgaa tccccggtcc atgttaccta
     8581 caaccctctc acctatgcat gggggccgca tgaacagtat gtgcgcacct acggaaacgg
     8641 ggaaaagggc catctgttcc tgggcatgaa tcccggcccc ttcggcatgg cccagacagg
     8701 cgtccccttc ggggaagtgg acgccgtcgt caactggctg cacatccgcg gagaagtcgg
     8761 gcggccggaa catacccacc ccaaacgtcc cgtggagggc ttcggctgcc ccaggtcgga
     8821 agtcagcggc cgccgcctct ggggactttt cgcggaagct ttcggcactg cggaaaactt
     8881 cttccgtcac aattacgtgg ccaattactg tccgctgatc tggatgggag ccaccggagc
     8941 caacattacg ccggacaaac tgccggcgga acagcgcgcc gccgtggacg cggtatgcat
     9001 ggaacacctg ctttccctca tcaccatcct gaatccccac acgctggtgg gggtgggcgc
     9061 ctacgccacg cagaagctgc gggatgccgc ctcccggctc ccccgcaaaa gcttcaccat
     9121 cggcacgttg ctccacccaa gccccgccag ccccatcgcc aacaagctct ggccggaacg
     9181 ccccatccag cagcttaagg aactgggcat tttataaaaa aagtggagga ggtagagcgg
     9241 agagttccgt gacatggaag gaatcaccag agcaacaggc cggaaatcgg cagttcatcg
     9301 tgttcccctc caaatctaca tcgcttcgaa ggaatgtccg gcccccttta ctggcttgat
     9361 ttgcccaggg acacggcttt cctgacggaa gaaatgcacg ccggcatcta ccggaacaga
     9421 gaagaactta aacgcctccc cacttccacc acaaaatcag cctccctcca aatcaatcat
     9481 cattcttaga ctgaaaaccc tccgctctcc cccgcaggcc tttttactgg acagggagaa
     9541 aagggttccg tacagtttcc gcgatcttca agcgttccga atttatggca atttcagatt
     9601 acatcgtgac cattggcctg gaagtccact gccagatcaa gacaaagagc aaaatgttct
     9661 gctcctgcga aaccggcttt ggctttgaac ccaatacgcg cgtgtgcccc acctgcctgg
     9721 ggctgccggg cgccctgccc gtcctgaatg agttcgccat cgaacgcacg ctgctgaccg
     9781 gcctgatgct gggatgttcc agcccggaga tttcccaatg ggaccgcaag aattatttct
     9841 atccggacat ggctaaaaat taccagacct cccagctgga tcttccgctg tgcctgggag
     9901 gggaagtgcc cctgtacccc tggtcctatc cgaatgacgt gatcaaagcc ggcgtccccc
     9961 ctttccgcac cgtgaagctg acccgcatcc atctggaaga agacgcggcg aagattaccc
    10021 atcatgccaa ttattccctg atcgactaca accgcgcggg gtccgccctg atggaaatcg
    10081 tttccgagcc ggacatcgac accccggaag aagcctacgc ctacctcaag tccctccagc
    10141 agattttgaa ttacggggat atctccgacg cggacatgga aaagggccag atgcggtgcg
    10201 atgtgaatat ttccctgcgt ccccacgggc agaaggaatt gggcgccaag gtggaaatga
    10261 agaacatcaa ctccatgtcc gccgtccgca gagcccttca ttatgaaatc cagcgccagg
    10321 cggaagaact ggacatgggc attcctcaaa tccagtccac ccgccgctgg gacgacgaac
    10381 gcggagaaag cgtcgtcatg cgaaccaagg aagacgcgca cgattaccgt tatttcccct
    10441 gtccggatct ggttcccgta cgcacggccc cgctggtgga gaaagtgcgc gggcagattc
    10501 ccgaactgcc tcaggaacgg cagaaacgct tcatggaaga atacggcctg agcgagtacg
    10561 acgccaacgt gctggtggga gacctggaac tggcacgctt ttttgaagag gcggcgcggg
    10621 gaaccgccag cggcaaaaaa atcgccaact gggtgattaa caacatttcc gccgtgctga
    10681 atggaaaagg catgcgcccg tctgaatgcc cggtgaaacc cggtgccatc cgggagctga
    10741 tcgccattat tgacgacggc accgtttcca acaaccaggc caaggacgta ttcgccaaaa
    10801 tgtgggatga gccggccctc gccgcagcgc aggccgccaa gctgctgggc tttgaaaagg
    10861 cggattcctc ttttctggac ggcatcgtgc gggaagtcat ttccgccaat ccggacaagg
    10921 tggcggaaat acaggggggc aatgaaaagc tcctgaactg gcttaccggc caggtcatga
    10981 aggccgccaa aggcaaagcc aacccgaaaa tcgtgacgga agcactgaaa aaagcccttt
    11041 ccatggagtg accataaaca aagagccgct tcccttgccg gtgccggctc cttgcccgca
    11101 gggcatcacg gtttgaacag cttcctgttt ccggccaggg tgttccatac ctgcttcact
    11161 tccccggcca gcgtctgctt catcatggca agggaaaagt ccgccgcctg gcccatactg
    11221 atgtagggag gcagggcaag ggcgtccctg tccacatgcg cgtccagcag agcggcgccc
    11281 ggataattca ggaacatgtc caccatctgg tccacctggc tggatttgtc caataaaaac
    11341 cccttgatgc cgacggcatc cgccacggcg gcaaaagagg ggttgttcag gttgatctgc
    11401 cacggaatca gcccggccgc ctgcatttcc aattggatga aatccagaca gtcattgtta
    11461 tacaccacga ttttcaccgg cagcctgtac tggacaatcg tgatgagatc ccccagcagc
    11521 atggacaggc cgccatctcc gcacagggca attacctgcc gttcggggta ttccatctgc
    11581 gccccaatag ccattggcat ggcattggcc atggagccat gattgaagga agccagcgtc
    11641 ctcctgcccg gcgtggcgca caggaacctg gcgctccaga tgcagggggt accggtatct
    11701 accgtaaata cggcgtcgga agccgcatgc ctgttcaggg cggtcgtgag ctgttccggc
    11761 cggatgggag actccttgtc atttccttcc atataggcgt tcatctcctt cacgtccctg
    11821 gcgtggcgtt tcagggcggc gtccaaatgc ccggaatccg tcttttcctg caccatgttc
    11881 agcagagcct ccgccgtgac ggaaacatcc ccgcaaatac ccaggtccag gcggcagcgg
    11941 cggcccagca cttcaccgcg cctgtcaatc tgcacgattt caggtttggt gggaatgaaa
    12001 ttgaaatagg ggaaatccgt cccccacaac acgagcatgt cgctttcatg catggccttg
    12061 taggcatctc cccatccaag cagccccgtc atgccgatgc ccaggggatt gtcatgttca
    12121 aaataatcct ttcccctcca tgtgtaggca atcggagctt tcaggcggtg cgcgagccgg
    12181 acgaccctgt cttccgctcc cgcgcagccg gcaccgcaga agaaagtaat gcggcggtgg
    12241 tcgtcaagca tccgtgccag aagggatacg gattcatgct caggaacaac attctcccgc
    12301 gtgtaggaag gaggatgcac cagattcttc atctccgcag gggcgtccgc aatgtctccg
    12361 ggcaagacga cgacacctac gtcgcgcctg gcccacgcgt gctgaatggc ggacatcaaa
    12421 atggacgggg cctgggaagc ttccgaaacc agttccgcat atgcactgca ttccttaaaa
    12481 agctgttccg gatgcgtggc ctggaaatat tccatgccta cctggctctg cgggatgtgg
    12541 gaagcaatgg ccagcaccgg ggcatggttc cggtgggcgt caaacaggcc gttgatcaaa
    12601 tggaggttcc cggggccgct gctgccgcag catacagcca gattcccgct cagctgggct
    12661 tccgcgctcg cggcaaaagc cgccacttcc tcatgccgca catgaatcca ttcaatggtc
    12721 ttcctcctcc tcaaagcgtc cgtaacgggg ttcaggctat cccccacaat gccgtaaatc
    12781 cgcttaactc ccgccttctc caaaatttca acaatctgat cggctaccct gtacatgcag
    12841 attagacacc agccaaccgc caacggattc attcttatgt gtcatcccct ccatcttttc
    12901 cgcaccggaa aaaatgcctg aggattttct cctgatatca taaggccgcc gccttttcag
    12961 gcagcggcct atgaatttac cagttctctg gcggaaaacc gtcaggaacg gcggcggcgc
    13021 atcatcagaa cggccaggcc caggattccc agagaagccg aggccggttc cggaacctga
    13081 aggccggcaa aaccggcaat ctgttccgcg gaaagttttg tatccgtcca ctgaatttca
    13141 ccccatgtaa gattgggatt aatccagctt tggatatcag tgcgatttcc gttcatgttg
    13201 ccgttgtagg acaacgtgtc aagcaaggaa ccattcacat agacctccac agactggctt
    13261 tggtttgcgc cggtaacggc caaagtcacg ttaagaagac ctccccccaa aacaacggga
    13321 gtttcagaaa cgtctccacg gttttgggaa aaagagccgg tagaagtatt caagttccca
    13381 tctcccatgc caaacttggc atctgacgtc agatacaagg catttgcccc gtaactttgg
    13441 cccgcattgg tgccataata cccaaacagc gtggtctggg ttccttccgt taaggaagag
    13501 gcatccagcc agagggagat cgtgtaattg gaagcataaa aattaccgcc gtaaggaatg
    13561 aaactgccag gaagggcact ttgtgagaga cttccaaacg tcatgtcttt tcccaacgca
    13621 ataccttcag ttgtcgtcgc cgtaccggca acgtaagacg ttccgtccga cggttctaaa
    13681 gagccgggag acgccaacgc cggaacggaa caacacgccg caatggccat taatgctaat
    13741 gtttttttca ttttctgtga atgatggact gagtagcaat tagagagata ttccccgccc
    13801 tctgtatatc ggattcccaa tccgctcttt ttctcccccc cacaggaaag atgagaacaa
    13861 gctttttcaa tctgccaaaa aatgtaatat aattaccttc tattacttat gaatataaaa
    13921 aataaaacgc agaatagatt tttttgtggc ggctctgaag ttgctgttta ggaacagcaa
    13981 tcccttttcg caaaatagaa aaaattgtaa taatagtttc acatctgaaa tgttaggttg
    14041 acctcggatt gggaatccgg ttgttttccc tcagccatca aaaaaaagca acataaggtt
    14101 ttcatattca ataaaaatc
//
