LOCUS       gnlProkkaFACPMCLC_49   14910 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|FACPMCLC_49.
ACCESSION   gnlProkkaFACPMCLC_49
VERSION     gnlProkkaFACPMCLC_49
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 20:45:26
            Original ID  :: gnl|Prokka|FACPMCLC_49
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 26544
            Orig. end    :: 41454
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14910
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:11422]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..11422
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..14910
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="neighbouring"
                     /product="RRE-containing"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     region          1..14910
                     /candidate_cluster_numbers="1"
                     /candidate_cluster_numbers="2"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /product="cyclic-lactone-autoinducer"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /rules="(TIGR04223 or AgrB)"
                     /tool="antismash"
     CDS             complement(41..526)
                     /locus_tag="ctg49_35"
                     /transl_table=11
                     /translation="MLICHKIRKTNNRMEENTMNKVILMGRLTRDPEVRYSTGENAMAI
                     ARYTLAVDRRFHREGEAEADFISCVAFDKRAEFAERYLQKGTKIAVSGRLTTGKYTNKE
                     GQTVYTTDVIIEECEFAESKNASERSRQADNSSPASAASGDGFMNIPDGIDEELPFN"
     CDS             complement(562..834)
                     /locus_tag="ctg49_36"
                     /transl_table=11
                     /translation="MNDNDIMARLILGNVGDETALRNICEAHNQCIDELAQEEKDHMYA
                     TNNFYYSAEEFSTIHSEETDELFHELLETGTLVATKDGFVWVNCV"
     CDS             complement(831..1202)
                     /locus_tag="ctg49_37"
                     /transl_table=11
                     /translation="MKSNRRAGSKRINEKKTHYMLFSCNEWKEYSSMRFLGATDNPETL
                     YVMIGSCIRADDMLYGCDNSKESWKHFQEDYHHSEINLDLLQYGYVETYEESRILSREF
                     AGEFPKAASTWRALGGKAG"
     CDS             complement(1174..2046)
                     /locus_tag="ctg49_38"
                     /transl_table=11
                     /translation="MATIKSFEVDRWSEKDEKGRVKHIGMLKMGEVFEMLKEHLLSKDM
                     LPDEYFLISKNDWNEDWELPDYDYAICIPNFGGSEGIYLDISLVYDDEQKQRRHMRFVT
                     GKTLEESADAFLKMARIAAECSLMLNGHGSRYRKSDVDVSLNPAQTLYLTDLLEKKFVN
                     SMDPNDRDMLSGLLKQFVCVSCVPVMAVCRQEDNLFSLWLHDMPDVRLDALILGSFVQK
                     GKLEDLMESLPVDGGQHLCLIREEKTGEYSLHTCDAGKFYHSVHGQEGRRLFGTKEEII
                     HEVKSQGGK"
     CDS             complement(2077..2559)
                     /locus_tag="ctg49_39"
                     /transl_table=11
                     /translation="MQSITKEPDRPDESTLKEMCLIVQAADAEADMGQYALETGNIVLS
                     MPEEVSMEAMRCIGTIIPGKKPAHVALCLQEFVAEAPKLYADGPEKKDLTYGFFAARHA
                     DTVISECAVYFPHTSTEEYLPIRILSVIMIFEDGRELDYSDKISSYVIDCLAKAAW"
     protocluster    2609..14910
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[12608:13330]"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      12609..13330
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR04223 or AgrB)"
                     /neighbourhood="10000"
                     /product="cyclic-lactone-autoinducer"
                     /protocluster_number="2"
     cand_cluster    2609..14910
                     /candidate_cluster_number="2"
                     /contig_edge="True"
                     /detection_rules="(TIGR04223 or AgrB)"
                     /kind="single"
                     /product="cyclic-lactone-autoinducer"
                     /protoclusters="2"
                     /tool="antismash"
     CDS             complement(2802..3869)
                     /locus_tag="ctg49_40"
                     /transl_table=11
                     /translation="MNTDYSAFYRGSAPAKTYGAGDTGRQTQVEKYEFNTTDEHGNKIM
                     DKMSREETLQAMSDVRSQYSSDVIVEFSGDGMAALVDSRKNYNGEYLDKVMKRSPEQRT
                     VPEDMITRLEGMYQKVSANDEINTHVSWHDTLKEKAPDVCDELDDLMQQILVRGINRSS
                     NGEKLGSKFVELVKKAENAISTYDAKKKNTVDDKNNAATVGETQLSEKAQALLTKLREG
                     YGDMDFFVANFNGGDNAVDIMSKSGKAYSVILTVEELEKMASDEKYEKEYMDRVQNARN
                     MAEQINKEYGFTSAGEATNKIKVGNIGISINEDGTITFLAALEKSSQREETTVQANNIE
                     ELIGKIKEWNKAIQN"
     CDS             complement(3942..5396)
                     /locus_tag="ctg49_41"
                     /transl_table=11
                     /translation="MVKKRLLSRVFATVMALAMIFAPANGFTVQAAENDASQIASRDIF
                     SEENPQDVISEDDIKYQEPVLINEFGAVEDTLPSRLTGTVQVEAAEIRDIPMTYDNSTV
                     IAGTVSDYLDSEGDALIYNINLAEGIYFQAQLTTPANANLDYDLYLLDADGNILKGSDY
                     YTYINGTDGTLQESIGFFPEGDEATYYIYVLASTGGSINQPFTLDYSLSIAYDRLESND
                     SVREAKSFTFDSNGAAIDYCTLSSPIDNDWFEITIPESRIYNRLNISATTASSNTCSVE
                     VYQNIASEGYKMQKVGNGGSVAVSTGTYYVRVSNAKSMDEYDDLDIQNYTLTITPVLSA
                     TNITITSLSGTEGSKYVTYSGYGNHFRTSTGTVTVSGYATIKDPETNTTYYAANTPVTI
                     MYYNPFWEENNTPNYAYVYAYGTTDSTGKYTIKVSLPNPTSSCSADTGVSYHYFDVCAI
                     YALASDNTSVNTYEVIFHYSYSVYHG"
     CDS             complement(5536..7242)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 252.1; E-value:
                     1.9e-76)"
                     /gene_kind="transport"
                     /locus_tag="ctg49_42"
                     /transl_table=11
                     /translation="MSNKEAVQKLLALLKGYQKIIAIIIFCLLLSTGLSLCIPLLSKRI
                     MDDGFIGGNKELLIKMVLGSFVIHLANSTIDIIKEKKRVDISSKIQYSLSEESFSHLMR
                     MKISYFSNKNYAEILNNINVDINNMTSIADEGVFFVVTQAFSMVGGVIGLFILDYRMTI
                     LVLLFIPIKYVVMKYFAKQRKKVMDEFIFINQKYSSWFGDTVGGVKEVKLFGIFANKHK
                     EFVEKQNEVISKQKKMNMLSQWNNITDTVLVCMLTTLIYIIGSNLVFNLQLSVGSIFAF
                     ITYSTYVTGPISAILNIGYLLSGIIPSTKRYYEFMYLEEEDESKEAKVLLQTGDIEFQH
                     VSFAYEKNKPVLKDINLRFPKGSKTALIGKNGSGKSTIVELLLRMYAPMKGQILLAGED
                     IFSTSLEVYRGIISVVSQEIYLFNDTIRNNICLYKQVDDSLILDVCRDSGLAEFVAEVT
                     LDYVVGQNGTMLSGGQKQKIALARALLHERPIVVFDEATSSTDSYSEQQINSLLHTKLK
                     DKTVIVITHRQEILNKVDFIVMLDEGQIVEQGSYEHIKKCGRYLDMVNVGS"
     CDS             complement(7235..8653)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S8"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1075:alkaline serine protease, subtilase family
                     (Score: 74.4; E-value: 1.8e-22)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_43"
                     /sec_met_domain="Peptidase_S8 (E-value: 6.3e-13, bitscore:
                     40.3, seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNIAIIDSGIRSELLEKPMNYNMEITEDKSCKNFLYNFGEQLFLH
                     GTNCALIIEKYCPEANLTGIKILDNDGKGILDKLEPALEWCFHKGITLINLSLGTTHFQ
                     DKNAIRQVVNHYVNKGMIFIAATANNGYKTYPASFSSVIGVASGDEFDINTNLLYHNGV
                     DLIAPSDHEIMVRENPVTLKNSNSYAAPYVTAKVCCLMSENQKYGICNLKNELFMRKTR
                     HFTAYYPDWIEKAWLPSQSRISNAPYYFLEVTGQYQDCIAQADTIVLSNRDEYATYGNV
                     GKHIVYLGKEPIECLDTNKFFWSREQRKEQITKCEKRVENIDIPCVVCRFEKTQDEILL
                     LSMMKMYFASDGYNAYTTSHKVESVLYDLEYIPKELCDENNIETVYNFLYWQTHYEQSD
                     IVIWALELNSYFGKKNNMVDVLVDFTYVEAGVQAEIYYDGIIKRKMIIKSIVHEEIKTI
                     YKYILALLKEENSE"
     CDS             complement(8659..8934)
                     /locus_tag="ctg49_44"
                     /transl_table=11
                     /translation="MNRKDVETQLKGIIKEKMNIELEQLKLDYMTNSLLDPEIGLVPRD
                     LLVIFFEMQILYGIEFDEKDVIEKRFDFFSNIVDSICEKIGVENMG"
     CDS             complement(8947..10014)
                     /locus_tag="ctg49_45"
                     /transl_table=11
                     /translation="MKTNNIAIFPYSNELYSFLGYIQVTQVMTVQYIISLKGYGIIGKE
                     IWVGDKKWTVQEQLSEEQYAKIDTIWITSLAANLATNILFEFIETAAERKLEIFITANL
                     KDEVKEEIKKINQKYSNHVDFLDDTVYEDCKYENNVMVNVPVITVFGVGEMTQKSDIQI
                     YLRNHFGDDFKVCQVGTNRDCKMLGMYSFPAFMSEKRYSEKEKICKFNHWIKELEDENK
                     PDVIILGIPGGIMPLNDKHTFDYGVLAYEIFSAIKPDYSIMTLYAGKYTDRFYEEMKEL
                     CKYRYDFELDSFFVSKYSPMSNSMKDDILNFVEISGAVNEKNNYLVYDSKALENSDMYV
                     DICHTLEVYSAFESI"
     CDS             complement(10001..11422)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Other_Sactipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_46"
                     /sec_met_domain="Other_Sactipeptide_rSAM_RRE (E-value:
                     1.2e-09, bitscore: 30.0, seeds: 13, tool:
                     rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 2.7e-10, bitscore: 32.4,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 1.3e-09, bitscore:
                     30.2, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTYLFKLYGECYIYSVFTNAIVKITEKLYEYLAGNISDESLTEI
                     DCSGLTYLRREGIISDKDNQFVISHSETDILEDMYRNNLKSMILQLTQNCNLRCKYCVY
                     SGSYTNRTHNNKRMNWDTAKRALDFLLEHSSASPKIAIGFYGGEPLLEFELIQKCVAYA
                     ETIFVGKELHFNMTTNATLLSDEMIYFFQEHGFNITISLDGPKEVQDSNRVLADNETGS
                     FNTVIEKIKMIDRVAPDFYNNVSFNAVVDLQNNVSDINDFFLSYDIIKNIFVSGNFVNP
                     NGRKDKAKFDRECYIASKYENFKTYLFYCTEIFSSYKPKLMNNLMDSLKKELYERTVIM
                     PKDEVNIAASGQCLPGLQRFFVSVDGNFFPCERVNENSCEYCIGNLEKGFDIVSAKRML
                     NVAHITEQECARCWNIRLCGQCVAMAEDNGEISRSMRLKKCDEMKKTSSEHIKDYIVLK
                     KYGCNFEKRDIYENK"
     CDS             complement(11704..12321)
                     /locus_tag="ctg49_47"
                     /transl_table=11
                     /translation="MAITSVTDYYSSYASYMNQSDKTRGESKTEEKIEKTSVLEQMKDK
                     YSDFEVTVGTFSQSQISSKNKGFQGVMISSAYLAKAENDGKTAKDLDDMLSGVESAYNW
                     LKNAFAKDGSELVSCGYYIDDKGNMGSYSVIKKKGSMFDGLQKQSDDMDKRIKEKREKK
                     AQEKKDAEKVKEQKQEEKKSETEDNKQKLEGQKTGNHVDYSI"
     CDS             complement(12609..13190)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: AgrB"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_48"
                     /sec_met_domain="AgrB (E-value: 2e-29, bitscore: 94.0,
                     seeds: 181, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEKYRNLIDKITYDLVMDNLIASSDVDAYKFGLEVTILKAFHYV
                     SYIVLALCMKKFFEFVIIFAVLYVFRRNTGGYHAQTRIGCYLFSCAVIFLSLLATEINF
                     SWQGATVISILDIIILLILSPVKNSNRNLDAEEIEYFRHRLRLWSVFFSMVYIATLGLR
                     AGYLITLYTIGVTMDTLLTILGKLQSIKQS"
     CDS             complement(13190..13330)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     cyclic-lactone-autoinducer: TIGR04223"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_49"
                     /sec_met_domain="TIGR04223 (E-value: 9e-12, bitscore: 36.7,
                     seeds: 127, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVSKIIATIINKNIQKEMNSACAIFGYQPVVPDSAKKFKNRKK
                     K"
     CDS             complement(13502..14800)
                     /locus_tag="ctg49_50"
                     /transl_table=11
                     /translation="MDRIILLFCSFISCVILVNLLFQFFNDRYLRAYNSKLLYILLPIV
                     SIIIVTPINMFMSPILNMLVNVIWIGFASYFFYYEEKDRRFIQIFESEALFMVIGVAEA
                     LGVFLIDVIMEIIQITPQSTEIQKSIETAFSKIVLLFLYYVVFSRLWKKSILRTKTQYI
                     LYLIMFVYSVVNVLIIAVISNRENPLVLMVIVGCTIFANMYLLYFIKFSDERNYYKMQL
                     EMMEQQEKIQYDNYEIQSAKYKEAMSILHDVDKHMKMIEGLYQEDFKREALNYTNQIRK
                     MLQPLVPFMYTDNPVLNCLLSDKKRVADRNGISFKIETNEVDINFMKPIDITTLFGNLI
                     DNALEATKKCNEEKYIGLYVKEYNEMISIRIENSVEDPVAVKNGKIYSSSAKRNGVGLL
                     NIQRCIEDYLGSIIYKYSNQLLVCDIVLNRVDE"
     CDS             complement(14804..14908)
                     /locus_tag="ctg49_51"
                     /transl_table=11
                     /translation="MDILLDTGGKVPLSQRRVKEFRERINEYLHDSFH"
ORIGIN
        1 ctttaaattt ggggaattag aaccgtccaa agtgtgatcc ctagttgaac ggaagttcct
       61 catcaatccc gtcagggata ttcatgaaac catcaccgga agctgcggat gccggactgc
      121 tattgtctgc ctgccggctc ctctcacttg cgttcttgct ttccgcaaac tcacattctt
      181 ctattatcac atcggttgta tatacagtct ggccctcctt gttggtgtat ttccccgtgg
      241 taagcctgcc gctgactgcg atttttgttc ctttttgcaa atacctttcc gcaaactctg
      301 cccgtttgtc aaaagcaacg caggatataa aatctgcttc cgcttcaccc tcgcgatgga
      361 acctccggtc taccgcaagc gtatatctgg cgatagccat tgcattctcc cctgtagaat
      421 accgtacttc gggatcccgt gtgaggcgtc ccatcaaaat tactttgttc atagtgtttt
      481 cctccattct gttatttgtt ttcctgatct tgtgacagat taacatgcgg caggctttcc
      541 tccattttca tctgctggtg tttacacgca gtttacccac acaaatccgt cttttgtagc
      601 aacaagcgtt cccgtttcaa gcagctcatg gaacagctca tcggtttcct cgctatggat
      661 ggtgctaaat tcctcggcac tgtaatagaa attgtttgtg gcatacatat gatccttttc
      721 ttcctgtgcc agttcgtcta tgcactgatt atgcgcttca cagatatttc tcagtgctgt
      781 ttcatctccc acatttccaa gtataagccg cgccataata tcattgtcat tcatcctgct
      841 tttcctccca gtgcccgcca tgtagatgct gccttgggaa attcccctgc aaattccctg
      901 cttaatatgc gggactcttc atatgtttcc acgtatccgt actgcagcag gtccagattt
      961 atttcgctat gatggtaatc ttcctggaag tgtttccatg actctttgga attatcgcat
     1021 ccatacagca tgtcatccgc cctgatgcat gagccgatca ttacataaag agtctccgga
     1081 ttgtctgtcg cgcccagaaa tctcatactg ctgtactctt tccattcatt gcaggaaaac
     1141 agcatataat gcgtcttttt ttcatttatt cttttacttc ccgccctgcg atttgacttc
     1201 atggataatc tcctccttag ttccgaacag tctgcgccct tcctgcccat gcacggaatg
     1261 atagaatttt ccggcatcac aggtatgcag gctgtattct cccgtttttt cttcccggat
     1321 cagacacaaa tgctgtccgc cgtcaacggg cagtgattcc atcaaatcct ccagctttcc
     1381 tttttggaca aagcttccaa gtatgagcgc atctaatcgt acatcaggca tatcatgcag
     1441 ccaaagtgaa aacagattat cttcctgtcg gcagactgcc atgaccggca cacagctgac
     1501 acagacgaac tgtttcagaa gccctgacaa catatcccga tcattcggat ccatgctgtt
     1561 gacaaacttt ttctccaaca gatccgtcag atacagtgtc tgtgccggat ttaacgacac
     1621 gtccacatcc gacttcctgt aacgcgatcc gtgtccgttc agcatcagcg aacattctgc
     1681 agcaatccgc gccatcttga ggaaggcatc cgcactttcc tcaagtgttt ttcctgtcac
     1741 aaagcgcata tgacgcctct gcttctgctc atcatcgtat accagtgaaa tgtcgaggta
     1801 tattccctcg cttccaccga aattcgggat gcatatcgca taatcgtaat ccggaagctc
     1861 ccagtcctca ttccagtcgt tcttgcttat caggaaatac tcgtctggca gcatgtcctt
     1921 gcttaacagg tgttctttga gcatttcaaa gacttccccc attttcagca ttccaatatg
     1981 cttcaccctg cctttttcgt ccttttcgct ccaacggtct acttcaaaac tcttaattgt
     2041 tgccatattt cttttttctc cttttctaaa ttgatgttac catgcggcct ttgccagaca
     2101 gtcaatgacg taagatgaaa ttttgtccga ataatccagt tccctgccgt cttcaaagat
     2161 cattatgacg gaaaggatac ggatcggaag atattcttcc gttgacgtgt gcggaaaata
     2221 aacggcacac tccgagatta ccgtatctgc atgacgtgct gcaaagaaac catacgttaa
     2281 atcctttttt tcaggaccat cagcgtacag ttttggcgct tctgcaacaa actcctgcag
     2341 gcaaagcgcg acatgtgccg gctttttacc tggtatgatt gtgccgatgc agcgcatggc
     2401 ttccattgat acttcctctg gcattgacaa gactatgttt cccgtctcta atgcatactg
     2461 ccccatgtct gcttccgcat ccgcagcctg gacaatcaag cacatctctt ttaatgtgct
     2521 ttcgtccggt ctgtctggtt ctttggttat tgattgcata aaacattccc tccttcttca
     2581 aaattttgca tatacacgat tttttcgcat aaaaaaagca cctgagctta taacccaagt
     2641 gcaattgcaa tcctgttatt tagttactat acctgtttcc aggaattaaa agaaatcata
     2701 ccgactatgc cggtaacatt gaaaaattta atgaacatga ggatattata atatataact
     2761 tcatgcttgt aaagatttta cttcgttacc agctttattt cctaattctg aattgcctta
     2821 ttccattctt tgatttttcc aatcaattcc tctatgttgt tcgcttgcac agtagtctct
     2881 tcccgctgac tagacttttc aagcgcggcg agaaatgtta ttgtaccatc ctcattgata
     2941 gaaatgccaa tgttgccaac tttaatctta tttgtagctt ctccagctga cgtaaatcca
     3001 tattccttgt tgatttgctc cgccatattg cgtgcattct gtaccctatc catatattct
     3061 ttttcgtact tctcatcaga tgccattttt tccagttctt caacggtaag tatgacagaa
     3121 taggctttgc ctgatttaga cataatatca accgcattat ccccaccgtt aaaattcgct
     3181 acaaagaaat ccatatctcc atagccttcc cttaactttg tcaaaagtgc ctgcgctttt
     3241 tccgataact gtgtttcccc aactgtggcc gcattatttt tatcatcaac cgtatttttc
     3301 ttttttgcat catatgttga aatagcattc tctgctttct tgaccagctc tacaaatttt
     3361 gaacctaatt tttcaccatt actactacga ttgattccac gaactagaat ctgctgcatc
     3421 aaatcatcta actcgtcaca tacgtcaggg gctttttcct ttaaggtatc atgccagctc
     3481 acatgtgtat tgatctcatc attggcagaa accttctgat acattccttc aagccgtgta
     3541 atcatgtctt ccggaacggt tcgctgttct gggcttcttt tcataacttt atcaagatac
     3601 tcaccgttat aattttttct gctgtctacc agcgctgcca ttccatctcc cgaaaactcc
     3661 acgattacat cactactata ttgagaacga acgtcactca ttgcctgcaa tgtttcttcc
     3721 ctggacattt tatccattat tttgtttcca tgttcatcag tagtattaaa ctcatacttt
     3781 tccacctgtg tttgtctgcc tgtatctccg gcgccatatg tttttgcagg tgctgatcct
     3841 ctgtaaaatg cactgtaatc cgtattcatt ttatatgacc tccctttgaa atgccaggag
     3901 caaggttgtt atccttgctc ctgattatat ttaaaacatc attatccgtg ataaacacta
     3961 tacgagtagt ggaatatcac ttcataggta tttacgcttg tattatcact tgccaaggca
     4021 taaatcgcgc atacatcaaa ataatgataa gatacacctg tatcggcact acagcttgaa
     4081 gtaggatttg gaagcgatac tttaatagta tatttccctg tcgaatctgt tgtgccgtat
     4141 gcatacacat aagcataatt tggagtatta ttttcctccc agaatggatt ataatacatt
     4201 atagttacag gagtatttgc tgcataatat gtggtattag tttcaggatc tttgattgtt
     4261 gcatatccgg agactgttac tgtacctgtt gaagtcctaa aatgattacc gtatcctgaa
     4321 taggtaacat acttcgaacc ctctgttccg cttaaagaag ttatggtaat gttcgttgca
     4381 gaaagaaccg gggtaatcgt gagcgtataa ttctgaatat ctaaatcatc atattcatcc
     4441 attgacttag cgttagatac tctaacataa taggttcctg ttgatacggc aacagaaccg
     4501 ccgttaccca ccttttgcat tttatacccc tcagatgcaa tgttctgata tacttcgact
     4561 gaacaggtgt tagatgaagc ggtagttgcg gaaatattca gcctgttata aattctgctt
     4621 tcaggaattg taatctcaaa ccaatcatta tcaatgggag aactcaacgt acaatagtca
     4681 atagccgcac cgttggaatc aaacgtaaat gattttgcct ctcttaccga atcattagac
     4741 tccaacctat catatgctat gcttaaagag tagtccaacg taaatggctg attaatactt
     4801 cctcccgtag atgccagcac ataaatataa tatgtagcct catctccttc cgggaaaaat
     4861 ccgatactct cctgtaaggt tccatcagtt ccatttatat atgtatagta atcagaacct
     4921 ttcaaaatat taccgtctgc atcaagtaaa tacaaatcgt agtccagatt cgcatttgca
     4981 ggagttgtta attgtgcctg aaaataaatg ccttctgcta aattaatgtt atagatcaat
     5041 gcatctcctt cagagtccaa atagtcactt acggtacctg caattactgt ggaattatca
     5101 taagtcattg gaatatctcg gatttctgcc gcctcaacct gaacagttcc cgtaagtctg
     5161 gaaggcagcg tatcttcaac tgcaccaaat tcattaatca gaacaggttc ctgatactta
     5221 atatcgtctt cggatattac gtcttgagga ttttcctcag aaaatatgtc cctacttgca
     5281 atctgagacg catcattttc tgccgcctga acagtaaacc catttgcagg cgcaaatatc
     5341 atagcgagcg ccataaccgt tgcaaacact cttgacaata gcctcttttt taccattttt
     5401 cagtacctcc tattatgtat ttatatatgc atattttcgc ctttttttca caatttgtta
     5461 atagcatttt ataaacgtac aactttttat cctgacgtac aatacagtaa tactgtttga
     5521 tattaaatac catatttacg aaccaacatt caccatatcc aaatatcgtc cacacttttt
     5581 gatatgttca tagctgccct gctccacaat ctgaccttca tcaagcatca cgataaagtc
     5641 caccttgttt aatatctcct gcctatgcgt aatgacaatt acagtcttat ccttaagctt
     5701 cgtatgcagc aatgaattga tttgctgttc agagtaacta tccgtactgg aagttgcttc
     5761 atcaaatacc acaatcggcc tttcatgcaa gagcgccctc gcaagtgcaa ttttctgttt
     5821 ctgtcctcct gaaagcatgg ttccgttctg ccccactaca tagtccagtg taacctcagc
     5881 aacgaactct gccaaaccac tgtccctgca aacatctaaa attaaactgt catctacttg
     5941 tttatagagg catatattat tgcggatagt atcattaaaa agatatattt cctggctaac
     6001 cactgaaatt attcccctgt aaacttctaa tgaggtacta aatatatcct ctcctgcaag
     6061 caatatctgc cctttcatcg gcgcatacat acgcaataac agctctacga ttgtactttt
     6121 accggaacca ttttttccaa tcagcgccgt tttgcttccc tttggaaatc taagatttat
     6181 atccttcaaa actggcttat tcttttcata tgcaaatgat acatgttgaa attctatatc
     6241 cccagtctgt aacaatacct tggcttcttt actctcatct tcttcctcca aatacataaa
     6301 ctcataatat cttttagtag aaggaatgat ccctgacagc aaatatccaa tattaagaat
     6361 tgcagatatt ggacctgtaa catatgtact gtatgtgata aacgcaaaaa tacttccaac
     6421 agatagttgc agattaaata ccaaattaga accaataata tatatcaaag tagtcaacat
     6481 gcaaactaat accgtatcgg taatgttatt ccactggcta agcatattca ttttcttttg
     6541 cttgctgatt acttcatttt gtttttcaac aaattcttta tgtttgttgg caaatattcc
     6601 aaaaagtttt acttccttta cacccccgac agtatctcca aaccagcttg aatatttttg
     6661 attgatgaat ataaactcgt ccataacttt cttccgctgc ttagcgaaat atttcataac
     6721 aacatattta attgggataa aaagcaatac taaaattgtc atacggtaat ccaagataaa
     6781 aagacctatc actccgccta ccatgctgaa cgcctgtgtt acaacaaaga acactccttc
     6841 atctgcaatc gaagtcatgt tatttatgtc tacatttatg ttatttaata tttcagcgta
     6901 gttcttatta ctaaaataac ttattttcat tctcataaga tgcgaaaaag actcttccga
     6961 taaggaatac tgtatttttg atgagatatc aaccctcttt ttctccttta taatatcaat
     7021 tgtagaattt gctaaatgta taacaaaaga acctaaaacc atttttatca gtaattcttt
     7081 attcccacca ataaatccat catccataat tctcttactc aacaagggaa tgcacaagct
     7141 taatcctgtt gacagcaata agcaaaatat aataatagcg attatttttt gataaccttt
     7201 taaaagcgca agcaacttct gcacagcttc tttattactc actattttcc tcctttaata
     7261 atgctaaaat atatttatat attgttttta tctcctcatg tactatactt ttaattatca
     7321 tttttctttt tattattcca tcataataga tttccgcttg cacacccgcc tcgacatatg
     7381 taaaatcaac taaaacatcc accatattgt ttttttttcc aaaataacta tttaattcta
     7441 gtgcccaaat aacaatatcc gactgctcgt aatgagtctg ccaatacaga aagttatata
     7501 ctgtttcaat attgttctca tcacataatt ctttaggtat gtactccaaa tcatacaata
     7561 cactttctac tttatggctt gttgtataag cgttataacc atcactagca aaatacattt
     7621 tcatcatact taacaatagt atttcatctt gtgttttctc aaatctacac acaacacagg
     7681 gaatatcaat gttttccact cttttttcgc attttgtaat ttgttccttt ctctgttccc
     7741 tactccaaaa aaatttattt gtatccaagc actctatagg ttccttgccg agataaacaa
     7801 tgtgctttcc gacatttcca tatgttgcat actcatcccg attagataaa acaattgtat
     7861 ctgcctgtgc tatacagtcc tgatattgtc ctgttacttc caaaaaataa tacggtgcat
     7921 tacttatcct actttgcgat ggaagccacg ctttctctat ccaatcagga tagtatgctg
     7981 taaaatgcct tgtttttcgc ataaataact cattttttaa attacatatc ccgtattttt
     8041 gattttccga cattaaacaa caaacttttg cagtaacata tggagctgca taactattac
     8101 tgttcttaag agtaactggg ttttctctta ccattatctc gtggtctgat ggtgctatta
     8161 aatcaactcc gttgtgataa agcaaattag tgtttatatc aaactcatct cctgaagcaa
     8221 caccaattac gctagaaaaa gaagcagggt acgttttata accgttattg gctgtcgctg
     8281 ctataaaaat catcccttta ttgacataat gattaacaac ctgacgaatt gcatttttat
     8341 cttgaaagtg tgttgttccg aggcttaaat ttatcaatgt gataccttta tggaaacacc
     8401 attcaagtgc tggttccaac ttatcaagta tcccctttcc atcattatca agtatcttga
     8461 tacccgtcaa atttgcctct ggacaatatt tctcaataat caatgcacaa tttgttccat
     8521 gaagaaacag ttgttctcca aaattatata aaaaattttt acatgattta tcttctgtaa
     8581 tttccatgtt ataattcatt ggtttctcta gcaattcgct tcttatgcca ctatcaataa
     8641 tcgcaatatt catattatct atcccatatt ctctacacca attttttcac atatactatc
     8701 gacaatattt gaaaagaaat cgaatctctt ttcgataaca tctttttcat caaattctat
     8761 cccatataaa atttgcattt caaaaaatat aaccaacaaa tctcgtggca ccaatcctat
     8821 ttccggatct aacaaactgt tcgtcatata atctaatttg agttgctcca attctatatt
     8881 catcttttct tttataatac cttttagttg cgtttcaacg tcttttctat tcataaattt
     8941 acctcgttat attgattcaa atgccgaata cacttccaat gtatgacata tatcaacata
     9001 catatcggaa ttttcaagtg ctttactatc atatactaaa taattattct tttcatttac
     9061 tgcaccagat atttctacaa agttaagtat atcatctttc atcgaattag acattggaga
     9121 atattttgaa acaaagaaac tgtccaactc aaaatcatac ctatacttac acagctcttt
     9181 catttcctca tagaatctat ccgtatactt tcccgcatat aatgtcatta tagaataatc
     9241 tggctttata gctgaaaaaa tttcatatgc taacacaccg taatcaaatg tatgtttatc
     9301 atttaatggc ataattcctc cgggaatccc taaaataatt acatccggtt tgttttcatc
     9361 ctctaactct tttatccaat gattaaactt acatattttt tctttctcac tatatctctt
     9421 ttctgacatg aatgctggaa atgaatacat tcctaacatc ttacagtctc tgtttgtccc
     9481 tacttgacaa accttaaaat catcaccgaa atgatttctc aaatatattt gtatatctga
     9541 tttttgtgtc atctctccaa cgccaaatac tgttataaca ggaacattaa ccatcacatt
     9601 attttcatat ttacaatctt cgtaaactgt atcatcaaga aaatccacat gattactgta
     9661 tttctgattt atctttttta tttcttcctt gacctcatcc tttagattag ctgtaataaa
     9721 aatctctaac tttctttctg ctgctgtttc aataaattca aataatatgt tcgtcgccaa
     9781 gtttgcagcc aagcttgtta tccagatcgt atcaattttg gcatactgct cctcagaaag
     9841 ctgttcttgt actgtccact ttttgtctcc tacccatatt tctttcccta tgatcccata
     9901 tccttttaaa gagattatat attgcacagt cattacttgt gtaacctgaa tataccccaa
     9961 gaacgaatac agttcgttgc tatatggaaa gattgctata ttatttgttt tcataaatgt
    10021 ccctcttttc aaaattgcat ccgtattttt ttaatacaat atagtccttt atatgttcac
    10081 tggatgtctt tttcatttca tcgcattttt tcagacgcat actcctagat atctctccgt
    10141 tatcctctgc cattgccaca cactgaccgc aaagcctaat attccaacac cttgcacact
    10201 cttgttcagt tatatgtgca acatttagca ttctttttgc gctgacaata tcaaaacctt
    10261 tttccaagtt gccaatacag tattcacacg aattttcatt taccctttcg caagggaaaa
    10321 agttgccatc aacactcacg aaaaatcttt gtagacctgg aaggcattgc ccactcgcag
    10381 caatatttac ctcatcttta ggcattatca ctgtacgttc atataattcc tttttcaaac
    10441 tatccataag attattcatt aactttggct tgtatgacga aaaaatttcg gtacaataaa
    10501 atagatatgt cttaaaattt tcatactttg acgcaatgta acactctcta tcaaactttg
    10561 ctttatcttt cctcccattt ggatttacaa agtttccgct cacaaatata ttttttatga
    10621 tatcatacga taaaaagaag tcgtttatgt ccgaaacatt attctgtaaa tcaacaaccg
    10681 cattaaaact tacattattg taaaaatccg gagcaactcg atctatcatt tttattttct
    10741 caattactgt attgaatgaa cctgtttcgt tgtctgcaag taccctattg ctatcttgta
    10801 cttccttagg tccatccaag cttattgtta tattaaaacc atgttcttga aaaaaataaa
    10861 tcatttcatc tgacaaaaga gttgcatttg ttgtcatatt aaagtgtaac tcttttccta
    10921 caaaaatcgt ttctgcatag gctacgcatt tttgaatcaa ttcaaactcc aagagaggtt
    10981 ctccaccata aaaccctata gcaatctttg gacttgcaga agaatgttct aataaaaaat
    11041 ctaatgctct ctttgccgta tcccaattca ttcttttatt attatgtgtt ctattagtat
    11101 aacttccaga atatacacaa tatttacatc taaggttaca gttttgggtg agctgtaaaa
    11161 tcatactttt caagttattt ctatacatat cttctaatat gtccgtttca ctatggctta
    11221 taacaaactg attgtcttta tcggatataa tcccctctct tcttagatac gtaagacccg
    11281 aacaatctat ctctgttaaa ctttcatcac taatatttcc cgccaagtat tcatataact
    11341 tttctgtaat tttcactatt gcattggtaa acacgctata aatataacac tcaccataca
    11401 acttaaataa atatgtattc ataaaaatct ccttttcaaa agggctgcta tcgcaatagc
    11461 agccctctct tacagcatga cattaagacc agccatttga gttattgttt gttgttacat
    11521 agttgtaaat ggaagtccct gtagctgtgg cagtcttgct attgcaattg gtacaagttg
    11581 tgccacaata gcaaaggcat gatgcattcg ttgcataagc aacaaatgta ccagatgaaa
    11641 ctctattttt ctttccgatc ttcttactca tcattttcac ctccctccaa ttcaagtgta
    11701 taactatatg gaataatcca catggttacc agtcttttgt ccttcaagct tctgtttatt
    11761 atcttctgtt tcactcttct tttcttcctg cttctgctct tttaccttct ctgcatcttt
    11821 cttctcttgt gcctttttct ctcgcttttc ttttatccgt ttatccatgt cgtcagactg
    11881 tttctgcaaa ccgtcaaaca tactgccttt cttcttaata acagaatatg aacccatatt
    11941 acctttgtca tcaatgtaat atccgcagga aactaattcc gaaccatcct tagcgaaagc
    12001 atttttcagc caattatatg ctgattccac tccactcagc atatcgtcta aatcttttgc
    12061 ggtttttcca tcattctccg ctttagcaag ataagctgaa cttatcatta cgccttgaaa
    12121 tcctttattt tttgatgaaa tttgactttg agaaaaagtc ccaacagtaa cctcaaaatc
    12181 agaatattta tctttcatct gttccaagac acttgttttt tcaatttttt cctctgtttt
    12241 gctttcccct ctagtcttgt ctgattgatt catataactc gcatatgagc tgtagtaatc
    12301 tgttacactt gtaattgcca tacaatttcc tccatttttt taattcaaca atttgtggtg
    12361 tttatggatt ccttagtagc tatgcatctt ctatggagat gtccatagaa ttctctgata
    12421 ctcgcactgt aattccatcc ttttattatt tgatgccata tctcttcggg tctgctgacg
    12481 cacttgaatt ttcacctccc aaaaaagata ataagtataa ctataatgtg cttcgtcaac
    12541 tttttatgat atgttaatac catttttcaa acgtacaact ttttgtcctg acgtacatat
    12601 tggcaagctt aggattgctt tatggattgc aatttcccca aaatagtcaa aagtgtatcc
    12661 atagtcaccc caattgtata caatgtaata aggtatccag cccttaatcc gagtgttgcg
    12721 atatagacca tagaaaaaaa tactgaccat aacctaagcc tatgtctaaa atattctatc
    12781 tcttctgcat ccaagtttct attgctattc tttactggcg acaatattag caatataatt
    12841 atgtcaagaa ttgaaattac tgtggcaccc tgccaactga agtttatctc tgttgccaaa
    12901 agagataaaa aaataacggc gcaggaaaac aggtagcatc caatcctcgt ttgggcatgg
    12961 taaccacctg tattgcgccg aaaaacataa agaacagcaa aaataattac aaattcaaaa
    13021 aatttcttca tacatagagc taatacaata taagaaacat aatgaaatgc ctttagtatg
    13081 gtaacttcca aaccaaactt ataagcgtcc acatcagagg aagctattaa attatccata
    13141 actaaatcat atgtaatttt atcaatcaaa tttctatatt tctcacccac tattttttct
    13201 ttctattctt aaactttttt gcggaatcag gtacaaccgg ctgatagcca aaaattgcgc
    13261 acgcactatt catttccttt tgaatatttt tattaataat agtagcaata attttagata
    13321 ctttcttcat ttattcttct cctttatttt tttgtgtaaa attttaccaa aaatatagca
    13381 ataatcaata gttttttcaa aatgtacaac tttttgttcc gatgtacaac ctaatatata
    13441 tgaatacaga taaatacgga cataaaaata ggatagacct aattaatcca tcctatttca
    13501 tctattcatc aactctattt aaaacaatat cacatacaag caactgattg gaatatttat
    13561 aaataatact acctaaataa tcttctatac atctctgtat atttaataat ccgacaccgt
    13621 ttctttttgc gctactgcta taaatttttc catttttaac tgctactgga tcttctacgc
    13681 tattttctat tctaatggat atcatctcat tatattcttt aacgtataaa ccgatatatt
    13741 tttcttcatt acatttttta gttgcttcta atgcattatc aatcaaatta ccaaataaag
    13801 tagttatatc tattggtttc ataaaattta tgtcgacttc atttgtttct attttaaatg
    13861 agattccatt tctgtctgcc actctttttt tatctgacaa caaacaattt aataccgggt
    13921 tgtctgtata cataaaggga accagcggct gcagcatttt tcgtatctga tttgtataat
    13981 ttaaagcctc tcttttaaaa tcttcctgat atagcccctc gatcattttc atatgcttat
    14041 caacgtcatg caaaatactc atagcctctt tgtatttcgc gctttgtatc tcgtagttgt
    14101 catattgaat tttctcctgt tgttccatca tctctaactg catcttataa taatttcgct
    14161 catctgaaaa ctttataaaa tacagcagat acatattagc aaagatggta catcctacaa
    14221 taaccatcaa tactaagggg ttttctctat tagaaataac tgcaataatt aaaacattga
    14281 caacgctata tacaaacatt attaagtaga gaatatattg cgtttttgta cgaaggatac
    14341 tctttttcca taatcggcta aaaactacat agtataaaaa caataataca atctttgaaa
    14401 aagcagtttc tatgcttttt tgaatctccg tactttgtgg agttatctgt attatttcca
    14461 taattacgtc aatcaagaaa actcctagtg cctctgctac acctataacc atgaataatg
    14521 cttccgactc aaatatttgt ataaatcttc tatctttttc ttcgtaataa aaaaagtagc
    14581 tagcaaaccc aatccagatt acatttacaa gcatattaag tataggactc ataaacatat
    14641 ttattggtgt aacaataata atacttacta ttggtaacaa tatgtacagt agtttactat
    14701 tataagctct caaatatcta tcattaaaaa actgaaacaa taaatttaca agaatcacac
    14761 aagatataaa tgagcaaaac aataaaataa ttctatccat accctaatga aatgaatcat
    14821 gcagatattc atttatcctt tccctaaatt ctttaactct cctttgcgac agcggaactt
    14881 ttccaccagt atccagtaga atgtcataca
//
