LOCUS       gnlProkkaJEEDFCII_19    8104 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JEEDFCII_19.
ACCESSION   gnlProkkaJEEDFCII_19
VERSION     gnlProkkaJEEDFCII_19
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 21:20:34
            Original ID  :: gnl|Prokka|JEEDFCII_19
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 8104
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..8104
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[441:3104]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      442..3104
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..8104
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..8104
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(40..261)
                     /locus_tag="ctg19_1"
                     /transl_table=11
                     /translation="MFYFTTCITIKNYWFGSTLQSIIQIMKTSCQVNGFNIRLTFRSRI
                     SKTTGPHPIKFTLNSVDFYTGIFYYQTC"
     CDS             442..840
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 96.3;
                     E-value: 2.7e-29)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_2"
                     /sec_met_domain="phosphonates (E-value: 8.4e-52, bitscore:
                     167.8, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1.5e-30, bitscore:
                     98.3, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIIARIESFIAGKGLDDALGRALAYIKAGADGIMIHSKDKSGEDI
                     KNFCLALRKIHKSIPIVVVPTTYNHISEDELASWGVNVVIYANHMLRSAYPAMLNTAKS
                     ILANARSYEANDLCMPIKEILELIPGTK"
     CDS             872..2002
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 69;
                     E-value: 6e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_3"
                     /sec_met_domain="TPP_enzyme_N (E-value: 8.7e-17, bitscore:
                     53.2, seeds: 75, tool: rule-based-clusters)"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.4e-20, bitscore:
                     65.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISPNIFVDSLGAMQMDFFTGVPDSLLKNICAYLTDHLASEHNII
                     AANEGAAIGLATGYYLATRKIPVVYMQNSGLGNAVNPLMSLTDKEVYNIPLLLLIGWRG
                     EPGVKDEPQHIKQGKVTLPLLEAMGIRYAVLSQDEKKFISQLNVAKSYMDETREPFAFV
                     IQKDTFLEYSSENCEDERLSLKREAAIHFIAASLTEKDIIISTTGMISRELFEYRESTS
                     LEHERDFLTVGSMGHASQIALGIALKKRDCKVYCFDGDGSTLMHMGSLAIVGSLHPENY
                     VHVVFNNGAHDSVGGQPTVALDIDLCKIAQACGYEIVLSVSDNEGLCEALKKIQQIRGP
                     ILLEVKVRKGARKNLGRPANTPIQNKEAFMLFLDNL"
     CDS             2010..3104
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Fe-ADH"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg19_4"
                     /sec_met_domain="Fe-ADH (E-value: 7.3e-76, bitscore: 247.2,
                     seeds: 218, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEQRFFLGESSIKELIPILQEYTPDHIFLVRGKKSYEKCGAQAVL
                     ESVFVKLACGVTEFFDFEANPKIEDMEKGLSLLKEYPTNMIIAIGGGSVLDMAKLLRFF
                     YSYSGNPTGGEFEKKRQLIPLITLPTTAGTGSEATHFSVLYKDKVKYSVEHDAILPDVA
                     IVYPKFTYGNSKYLTSCTGFDALAQAIEAYWNVNATEESDKYAAKAIKLLWPNLPLVVN
                     SPTAEARNKVSEGSYWAGRAINITKTTAPHAFSYSFTTDYGYPHGHAVALTFPFFMRYN
                     IGNSDILLNPNINPYLYKIKMQKMLQWLNMECVDVAIAMKEYIRNLGLDIDISQIDISK
                     IVSSVNIQRLINNPYKVEAICLEE"
     CDS             3089..3805
                     /locus_tag="ctg19_5"
                     /transl_table=11
                     /translation="MSRGISEKEQRWLLVLSQVIEVLDKNNLLYFIDTGTLLGAVRDKM
                     FIPWDNDIDLAVIGGDTSTTNLLKVSKLLYALGFYVTLTKKEIAICSRDGVNLGIKLYK
                     KQASHYEACMGKVYRHRLFYSINLYLSGEVLYKKGFSFKYKAISLFVKFSQVFKLKLSC
                     IWQMKLLFWAKYDEKTVIIPFEFVDAIIDYNFYNIIVKVPNKPERYLAYRYGENWKVPK
                     QDYDYMIDDKSIINID"
     CDS             4398..5075
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_6"
                     /sec_met_domain="Glycos_transf_1 (E-value: 7.9e-13,
                     bitscore: 40.3, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAFWTENPYISEKVKHLFPTIKAYTVSNYYNQVFDDENTQIEHA
                     LPSFDGCTLLSINAPYPHKNLAIAIEVARYLKKHYSEFSFRFVFTVTENDLPPIPSYLR
                     EHFCLIDKVSVAECPSLYRQADIMFQPTLLECFTATYVEAMRMQVPILTTDLPFAHGLC
                     GNAAVYYSPLDAEDCAKSIYKMAVDTSFQDYLVGEGIKQLKSFDNYNRRAEKLIDLISN
                     LDD"
     CDS             5090..6163
                     /NRPS_PKS="Domain: NAD_binding_4 (10-144). E-value:
                     4.5e-07. Score: 21.1. Matches aSDomain:
                     nrpspksdomains_ctg19_7_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     105.1; E-value: 7.9e-32)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_7"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.4e-108,
                     bitscore: 353.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6.3e-08, bitscore:
                     23.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVFKDKVLLITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQD
                     DMRHHLQNPKVKFYIGNVRDRQSVDGAMMGVDYVFAAAALKQVPSCEFFPLQAVQTNVI
                     GTDNVLESAIAHGVKNVVVLSTDKAAYPINAMGISKAMMEKVAIAKGRALGEEAGTTIC
                     CTRYGNVMASRGSVIPLWVEQIKNGRPITVTDPNMTRFMMTLDDAVDLVIYAFEHGHNG
                     DLFVQKAPAATLDVLAQALKETYAQVDPKYGETEVKTIGTRHGEKLYETLVTREEMAKA
                     VDMGDYYRIPCDTRDLNYDKFFTEGNEDIARIEDYHSHNTARLDVEGMKKLLLKLRFIR
                     EDLGMEEKAKSAEIKSE"
     CDS_motif       5117..5173
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg19_7_0001"
                     /evalue="1.70E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg19_7"
                     /protein_end="28"
                     /protein_start="9"
                     /score="11.1"
                     /tool="antismash"
                     /translation="LITGGTGSFGNAVLRRFLD"
     aSDomain        5120..5521
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg19_7_NAD_binding_4.1"
                     /evalue="4.50E-07"
                     /label="ctg19_7_NAD_binding_4.1"
                     /locus_tag="ctg19_7"
                     /protein_end="144"
                     /protein_start="10"
                     /score="21.1"
                     /tool="antismash"
                     /translation="ITGGTGSFGNAVLRRFLDSDIKEIRIFSRDEKKQDDMRHHLQNPK
                     VKFYIGNVRDRQSVDGAMMGVDYVFAAAALKQVPSCEFFPLQAVQTNVIGTDNVLESAI
                     AHGVKNVVVLSTDKAAYPINAMGISKAMME"
     CDS             6264..6485
                     /locus_tag="ctg19_8"
                     /transl_table=11
                     /translation="MAATVLNSVQQHLLKMFAFDGSEERLNEVKEVLTKYFSQKLDDRL
                     NDLWDSGVLNQEKLDELRKIDVRTLPKR"
     CDS             6482..6886
                     /locus_tag="ctg19_9"
                     /transl_table=11
                     /translation="MNRIVLDTNSLIQCISPKSRYRKIWDCFLDGTNQLCVSDEILNEY
                     EEILERLAGVEIAKLVIDVILNSPYTLFFTPYYNFNLIKSDPDDNKFVDCAVVANAKFI
                     VTEDHHFHILKQYNFPKVSFIGLDDFCHSL"
     CDS             6939..8075
                     /NRPS_PKS="Domain: NAD_binding_4 (99-186). E-value:
                     3.1e-09. Score: 28.1. Matches aSDomain:
                     nrpspksdomains_ctg19_10_NAD_binding_4.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 87.9;
                     E-value: 1.3e-26)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg19_10"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 2.8e-09,
                     bitscore: 28.4, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTGARGFVGRNLVSQLHNIRDGKARNYGIASEELAIYEYDMDSDP
                     AELDVYCRQADFVFNLAGVNRPQDASEFMKGNFGFASTLLDTLRKHGNTCPVMISSSTQ
                     AALDNPYGESKRAGEQLLFEYSRETGAKVLVYRFPNVFGKWCRPNYNSAVATFCHNIAH
                     DQPIRVNDPSVVMNLVYIDDVVDELVSAMGGREHRNGDYCEVPVVHTITLGGIVELIRS
                     FRQMPGTLSVPDLSDAFTKKLYSTYLSYLPEERFSYPLKMNVDDRGSFTEIIRTSDRGQ
                     FSVNISKPGVTKGQHWHHTKNEKFVVVSGHGLIQLRKIGTEEVVSFEVNGGRMEVVEMI
                     PGYTHNIVNLSETEDLVTFMWCNECFDPARPDTYFEKV"
     aSDomain        7236..7496
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg19_10_NAD_binding_4.1"
                     /evalue="3.10E-09"
                     /label="ctg19_10_NAD_binding_4.1"
                     /locus_tag="ctg19_10"
                     /protein_end="186"
                     /protein_start="99"
                     /score="28.1"
                     /tool="antismash"
                     /translation="SSSTQAALDNPYGESKRAGEQLLFEYSRETGAKVLVYRFPNVFGK
                     WCRPNYNSAVATFCHNIAHDQPIRVNDPSVVMNLVYIDDVVD"
ORIGIN
        1 gctaaaagta ttgttcgtat ctgtgaatct catagtgggt taacaggttt gataatagaa
       61 aataccagtg tagaagtcaa cggagttaag cgtgaatttg atgggatgtg gtccagtagt
      121 cttactgatt cgacttctaa aggtaagcct gatattgaag ccgttgactt gacaactcgt
      181 cttcatgatt tgaatgatgc tttggagtgt actaccaaac cagtaatttt tgatggtgat
      241 acaggtggta aaatagaaca ttttgtattt actgttcgca cgctggaacg tttagggata
      301 tcagctgtta ttatcgagga taaaataggt ctgaagaaga actcgctttt tggaacagac
      361 gctgttcaga cccaggatac aattgaaggg ttttgtgata aaattcaagc gggtaaacgt
      421 gctcagataa cggatgattt tatgataata gctcgtattg aaagttttat tgctggaaaa
      481 ggtttagatg atgctttagg acgtgcatta gcatatatta aagcaggtgc ggatgggatt
      541 atgatccata gcaaagataa gtctggtgag gatataaaga acttctgtct tgctttacgc
      601 aaaatacata aatccattcc gatagtggtt gttccaacta cttataacca tatatcagaa
      661 gatgaattgg cttcttgggg agtaaatgtt gtaatatatg caaatcatat gcttagaagt
      721 gcatatcccg ctatgcttaa tacggcgaag tccattcttg ccaatgcacg ctcttatgaa
      781 gccaatgact tatgcatgcc tattaaagaa attctggaat tgattccagg gactaagtaa
      841 atagactctt taaaattaaa ttcttattat tatgatttct cctaatattt ttgtagactc
      901 tcttggcgct atgcagatgg atttttttac tggagttccc gattctttat tgaagaatat
      961 atgtgcatat ttaacagatc accttgcttc tgaacataac attattgccg ctaatgaagg
     1021 tgctgctata ggtttggcta caggatatta tttggctacg aggaaaattc cagttgttta
     1081 tatgcagaat tcaggtcttg gaaatgcagt aaatccttta atgtcattga cggataaaga
     1141 agtttataat attccattgt tattgctaat tggttggcgt ggtgaacctg gtgtgaaaga
     1201 tgagccacaa catattaagc agggaaaagt cacacttcca ttacttgagg caatgggtat
     1261 cagatatgct gttttatctc aagatgaaaa gaagtttata tctcaactta atgttgcaaa
     1321 atcttacatg gatgagacaa gagagccttt tgcttttgta attcagaaag acactttctt
     1381 agagtatagt tctgaaaatt gtgaagatga acggttgtct ttgaaacgcg aagctgctat
     1441 tcatttcata gcagcttcat taacagaaaa agatattata atatcgacaa caggtatgat
     1501 atcacgtgaa ttatttgaat atcgtgaatc tacttcttta gaacatgaga gagatttttt
     1561 gactgtaggt tctatggggc acgcgtcgca gatagcattg ggaatagctc ttaaaaagag
     1621 agactgtaaa gtttattgct ttgatggaga tggttccact ttgatgcata tgggttcgtt
     1681 agcaattgtc ggttctttac atccggaaaa ctatgtacac gtagtcttta ataatggcgc
     1741 tcacgattct gtggggggac aaccaacagt cgctttagat attgatttat gtaaaattgc
     1801 tcaagcttgt ggttatgaaa tagtattgtc tgtttctgat aacgaaggtt tatgtgaagc
     1861 tcttaaaaag atacagcaaa tacgcggccc tattttgttg gaagtaaagg ttcgaaaggg
     1921 agctcgtaag aatttgggaa gaccagccaa cactcctata caaaataaag aggcattcat
     1981 gcttttctta gataatttat agagtaatta tggaacagcg ttttttttta ggagagtctt
     2041 ctataaaaga attgattcct atcttgcaag aatatactcc tgatcatata tttcttgtaa
     2101 gaggaaaaaa gtcttatgag aaatgtggtg cacaggctgt gttagaatct gtttttgtta
     2161 aattagcttg tggcgtgacg gaattctttg attttgaagc aaatcctaaa attgaagata
     2221 tggaaaaagg actttcatta ttgaaagaat atccgacaaa tatgattatt gctataggtg
     2281 gaggtagtgt attagatatg gcaaaattgc ttcgtttttt ttattcctat tctggtaatc
     2341 ctacgggggg ggagtttgaa aagaagcgac aattaattcc attaataaca cttcctacta
     2401 cagctggtac aggtagtgaa gcaactcatt tttctgtttt atataaagat aaagtaaaat
     2461 attcagtaga acatgatgct attcttccgg atgtagcgat tgtatatcca aaatttactt
     2521 atggaaattc aaaatatcta acatcttgta caggctttga tgctctagcg caggcgatag
     2581 aagcttattg gaatgtgaat gctacggaag agtcggataa atatgcggcg aaagcaatta
     2641 aactcttatg gcctaatttg ccattggttg taaattctcc tacagcggag gctaggaata
     2701 aggtttcgga aggctcttat tgggctggtc gtgcaattaa tataactaag actacagctc
     2761 cacatgcttt ttcgtattca tttacaactg attatggata tccgcatgga catgcagtag
     2821 cattaacatt tccctttttt atgagatata atattggaaa ttcggatatc ttattgaatc
     2881 ctaatataaa tccttactta tataagatta aaatgcaaaa aatgttacag tggttaaata
     2941 tggaatgcgt agatgttgca atcgctatga aagagtatat aagaaacttg ggattagata
     3001 ttgacatatc tcaaattgac atatcgaaaa tcgtatcttc tgttaatatt caaagattaa
     3061 taaacaatcc atataaagtt gaagcgatat gtctagagga ataagtgaaa aggagcaacg
     3121 atggttgtta gtattatcac aagttattga agttcttgat aaaaataatt tattatattt
     3181 tattgatact ggtactcttt taggagctgt tagagataaa atgtttattc cttgggataa
     3241 tgatattgat ttagcagtta ttggaggaga tacatctact actaatttgc ttaaagtgtc
     3301 aaaattgtta tatgctttag gcttttacgt cactttgaca aagaaagaaa ttgctatctg
     3361 ttctagagac ggggtaaatt taggaattaa attatataaa aagcaagcaa gtcattatga
     3421 agcatgtatg ggaaaagttt atagacatag actattttat tctataaatt tatacctctc
     3481 tggagaggtc ctgtataaaa aaggcttttc ttttaagtat aaagctatct cactctttgt
     3541 gaagtttagt caagtcttta agttaaaatt gtcttgtatt tggcaaatga agttattgtt
     3601 ttgggctaag tatgatgaaa agacggtgat tattcctttt gagtttgtag atgcaattat
     3661 tgattataat ttttataata taattgtgaa agtgccaaat aagccagaaa gatatctagc
     3721 atatagatat ggtgaaaatt ggaaggttcc caaacaagac tatgattata tgattgatga
     3781 caagtctatt ataaatattg attaaaaaaa tatgaaaaca aatttcaaca taaggagtat
     3841 tattgtaatt aataaaatta taatcaactt tttctttaga caatatagat ggtatttata
     3901 aatagcactt tcatttatac accaaaattg ggcacttata tattatattc tcggaacaaa
     3961 tgaacattct aataaattgc tccaatctca agaaaggtgg agggcttcaa gtcgctgatt
     4021 cggtttgttc ttgtttgaat acaattcccc aacatgattt ttttttagta ttatcctcat
     4081 gtatggatga tactgctgat agggtatcgg aatacaaaaa tgtcactgta gtgcgtcatg
     4141 atatacgaaa cagttggtat acattgtttt ggggacgtga taaggctatg gataatttgg
     4201 taaccagaca caatattggt ggagttctta ccatattcgg acctgcaaga tggaagccga
     4261 aatgtaagca tctatgtgga tttgccagat cccatctcgt tttgaacgat tctccctatt
     4321 ttcaacgtat gtcttggaag gaactaatga tagaaaaggc gagaaatctt tatttatatt
     4381 attacttcaa acgtggtgtg actgcttttt ggactgagaa tccttatatt tcagagaaag
     4441 taaagcactt gttccctacc ataaaagcct atactgtatc gaattattat aatcaggttt
     4501 tcgatgatga aaatactcaa atagaacatg ccttaccgtc ttttgacggt tgtactttac
     4561 tgtccataaa tgctccttat cctcataaga atttagcaat tgctatcgaa gtcgctcgat
     4621 atcttaaaaa acattattcc gaatttagtt ttcgattcgt ttttacggtg acagagaatg
     4681 acttgccacc tattccttct tatttgcgag agcatttctg tctgattgat aaagttagtg
     4741 tagcagaatg cccttcctta tatcgtcagg cagatataat gtttcaacca actttacttg
     4801 aatgtttcac tgccacatat gtcgaagcga tgcgaatgca agtgccaatt ttaactacag
     4861 atttgccatt tgctcatgga ttatgtggaa atgcagctgt gtactattcg ccgttagatg
     4921 cagaagactg tgccaaatca atttataaaa tggctgtaga cacatccttt caagattatc
     4981 tggtcggaga aggaataaaa caacttaagt ccttcgataa ttataatcgg agagcagaaa
     5041 aattaatcga tttgatatcg aatttggatg attaatacat attatattta tgtcagtatt
     5101 taaagacaaa gtcctcctta taaccggagg taccggcagt tttggtaacg ctgtattgcg
     5161 tcgtttcctt gattctgata tcaaggagat tcgtattttt agtcgtgacg agaaaaagca
     5221 ggatgacatg cgtcatcacc tgcaaaatcc caaagtaaaa ttttacattg gtaatgtccg
     5281 tgaccgccag tctgtagacg gtgccatgat gggagtggat tatgtatttg ccgctgccgc
     5341 cttgaagcag gttcccagtt gcgagttctt cccgttgcag gctgtgcaga ccaatgtgat
     5401 cggtacggac aatgtactgg aatctgccat agcgcatggt gtaaagaatg tggtggtgct
     5461 ttctaccgac aaggccgcct atcccatcaa tgccatgggt atcagcaagg ccatgatgga
     5521 gaaggttgcc atagccaagg gccgtgcgtt gggtgaggaa gccggtacga ccatctgctg
     5581 tacccgttac ggcaatgtga tggcaagccg cggttctgta attcccttgt gggtggagca
     5641 gataaagaac ggcaggccca ttacggtaac ggaccccaac atgacccgct tcatgatgac
     5701 gctggacgat gccgtggatc tggtaatcta tgcgtttgag cacggccata acggtgacct
     5761 gttcgtgcag aaggctcctg ccgccacctt ggatgtactg gcgcaggcct tgaaggaaac
     5821 atacgcgcag gttgatccga aatacggtga aacggaggtg aagaccatcg gcacgcgcca
     5881 cggcgagaaa ctgtatgaga cactggtaac ccgcgaagag atggcaaagg ctgtcgacat
     5941 gggcgactac taccgcatcc cttgcgacac ccgtgacctg aactatgaca agttcttcac
     6001 ggaaggcaat gaggatattg cccgtataga ggactatcac agccataaca ccgcccgcct
     6061 ggatgtggag ggcatgaaaa agcttctttt gaaactccgc ttcatccgcg aagacctcgg
     6121 gatggaggaa aaggcgaaga gtgcggaaat caagagtgaa taagtcttta atttgaataa
     6181 tacaacagga aagaaagagg gaatgtattg ctcctttaga aaaaaaaact atctttgcca
     6241 tattgaaact aataattgag aatatggcag caacagtatt aaattcggtc cagcaacatc
     6301 ttttgaagat gtttgctttt gatggttcgg aggagcgatt gaatgaagtt aaagaagtgt
     6361 tgaccaaata tttttctcag aagttagatg accgcttgaa tgacttatgg gattcgggag
     6421 ttttaaacca agaaaaactt gatgaactga gaaaaattga tgtccgcaca cttccgaaga
     6481 gatgaatagg attgtattag atacaaatag cctgatacag tgcatttctc ccaaaagcag
     6541 gtaccgtaag atttgggatt gctttctgga tggaacgaat cagttatgcg tttctgatga
     6601 aattctaaat gaatatgagg aaatattaga acgtttggca ggtgtggaaa tagctaagct
     6661 ggtgattgat gtcattctca atagccctta tactttgttc tttactcctt attataactt
     6721 caatctgata aaatcagatc cggatgataa taagtttgtg gactgtgcag ttgtggctaa
     6781 tgccaagttt attgttacgg aagatcatca ttttcatata ttgaagcaat ataatttccc
     6841 aaaagtaagt tttataggtt tggatgattt ctgtcattca ctatgaatat cttctctttt
     6901 ctgtgacaaa cagaacccat tagtttatga aaatcttagt gaccggcgcc cgagggttcg
     6961 tcggccggaa ccttgtatcc cagctgcaca acatccgtga cgggaaagcc cgcaattacg
     7021 gcattgcaag tgaggaactt gccatttacg agtatgacat ggacagtgac cctgccgaac
     7081 tggatgtcta ttgcaggcag gctgactttg tcttcaatct ggcgggcgtg aaccgtcccc
     7141 aggatgcgtc tgagtttatg aaagggaact tcggcttcgc ctccacgctg ctcgacacat
     7201 tgaggaaaca cggcaatacc tgtccggtaa tgatctcctc ttccacgcag gccgcactcg
     7261 acaaccctta cggtgaatcg aagcgggcag gggagcaact gttgttcgaa tactccaggg
     7321 aaacgggggc gaaggtactg gtgtaccgct tcccgaatgt tttcggcaaa tggtgccgcc
     7381 ccaactataa cagcgcggtg gccactttct gccataacat cgcccatgac cagcccatcc
     7441 gggtgaacga cccttcggtg gtgatgaacc tggtttacat agacgatgtg gtggacgagc
     7501 ttgtctctgc catgggcggc agggaacacc gcaacggtga ttattgcgaa gtgcccgtag
     7561 tacataccat taccttgggc ggcattgtgg aactgataag gtctttcaga caaatgcccg
     7621 gtaccttgtc cgtcccggat ttgagcgatg cctttacaaa gaaactctat tccacatacc
     7681 tctcatacct gcctgaagaa cggttcagct atcccctgaa aatgaatgtg gacgaccgcg
     7741 gcagttttac ggagattatc cgtacttccg accgcgggca gttctcggtg aacatctcca
     7801 agccgggcgt tacgaaaggc cagcactggc accataccaa gaacgagaag tttgtggtgg
     7861 tgagcgggca cggtctgata cagctccgca agataggtac ggaggaggtt gtcagcttcg
     7921 aggtaaacgg cgggaggatg gaggtcgtgg agatgattcc cggctatacg cacaacattg
     7981 tcaacctttc ggaaacggaa gacctggtga ccttcatgtg gtgcaacgag tgtttcgacc
     8041 cggcacgtcc ggacacttat tttgaaaaag tctgaaacga gttaaagaat ataggaacag
     8101 atgg
//
