LOCUS       gnlProkkaIDGPNNPL_32   10654 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IDGPNNPL_32.
ACCESSION   gnlProkkaIDGPNNPL_32
VERSION     gnlProkkaIDGPNNPL_32
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-12-01 23:31:36
            Original ID  :: gnl|Prokka|IDGPNNPL_32
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 35790
            Orig. end    :: 46444
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10654
                     /aStool="rule-based-clusters"
                     /category="other"
                     /contig_edge="True"
                     /core_location="[5000:9288]"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..9288
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /neighbourhood="5000"
                     /product="phosphonate"
                     /protocluster_number="1"
     cand_cluster    1..10654
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(phosphonates and minimum(1,
                     [2-Hacid_dh_C, Aldedh, Aminotran_1_2, Aminotran_5, AurF,
                     CTP_transf_like, DUF4992, Fe-ADH, HMGL-like, Metallophos_2,
                     NTP_transf_3, NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C,
                     TPP_enzyme_N, phosphonates]) and not (phosphonatesHydrolase
                     or phosphonatesMeIsocitrateLyase))"
                     /kind="single"
                     /product="phosphonate"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10654
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="phosphonate"
                     /region_number="1"
                     /rules="(phosphonates and minimum(1, [2-Hacid_dh_C, Aldedh,
                     Aminotran_1_2, Aminotran_5, AurF, CTP_transf_like, DUF4992,
                     Fe-ADH, HMGL-like, Metallophos_2, NTP_transf_3,
                     NTP_transf_5, PALP, PEP_mutase, TPP_enzyme_C, TPP_enzyme_N,
                     phosphonates]) and not (phosphonatesHydrolase or
                     phosphonatesMeIsocitrateLyase))"
                     /tool="antismash"
     CDS             complement(562..795)
                     /locus_tag="ctg32_36"
                     /transl_table=11
                     /translation="MKQSFNDHKQGCSWPLGVTNSKAFTDEVRSPRLLRTRCKRIVQQL
                     KRHQTPLFIVGQTRKCRKTTLTDLCNPRAVLY"
     CDS             1630..1971
                     /locus_tag="ctg32_37"
                     /transl_table=11
                     /translation="MFVHSTKQTACDISNIYNVPLFYMKDLATHSMLVVPDKQMEDFMF
                     VMDLNPDGVSLDSEILTVGHKVKVIKGELSGIEGEVAIEANKTYVVIRIKDLLTASIKV
                     PKSYLKIIG"
     CDS             2017..2499
                     /locus_tag="ctg32_38"
                     /transl_table=11
                     /translation="MNDLTSRALELQHAAHELMYLGMDGEPVYSDNFCRLNKEVLVKSD
                     SLFSAQSSDVEEEANLCLALLMGYNATIYDDGDKEQKKQMVLNRICLVLEQLPASLLKV
                     RLLTYCYGEIYEEVLLQEAHAIIEGWNRDELTLEQTEIIEELKNIEENPYPFEEVE"
     CDS             2549..3754
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1152:nucleotide sugar dehydrogenase (Score: 385.1;
                     E-value: 6.1e-117)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_39"
                     /transl_table=11
                     /translation="MKACFMGLGYIGLPTAIIAAKHGIQIIGVDINPKVVEMTNQGKLH
                     IIEPGMQELLQEVVTTGQLKASTTPEVSDAYFMVVPTPFKGNHEPDISYVEAATRAVIP
                     LLKEGDLYVIESTSPVGTTDKMCDLIFGLRPELRDKIYIAYCPERVLPGNVIYELVHND
                     RVIGGLNEASTDRATEFYSKFVRGTLHRTNCKTAEMCKLTENSSRDVQIAFANELSLIC
                     DKAGINVWELINLANKHPRVNILQPGCGVGGHCIAVDPYFITAEFPMESKIISTAREIN
                     NYKAFWCAEKVQNAMLKFELEYHRKPTIAMMGLAFKPDIDDLREAPAKYITTKVMQSCN
                     NADILVVEPNVQEHNVFKLTDYKEAYEKADIVVFLVAHSVFKSLPYNDRKVILDFCGIY
                     KK"
     CDS             3770..4921
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Epimerase_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_40"
                     /sec_met_domain="Epimerase_2 (E-value: 6.1e-124, bitscore:
                     404.9, seeds: 187, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKIMLVFGTRPEAIKMAPLVKEFQKYPEEFKTIVCVTGQHREML
                     DQVLHIFEIIPDYDLNIMKPGQDLYDVTARVLIGMRDVLKEVQPDVVLVHGDTTTSTAS
                     ALAAFYQQIPVGHVEAGLRTHNIYSPWPEEMNRVITGRIASYHFSPTPLSRQNLLDEGV
                     RESAITVTGNTVIDALYMVVDKIKSDKRLDEELKGILKTAGYDINRLLDGKKLVLITGH
                     RRENFGDGFVSMCRAIQTLTKKYPNVDFVYPMHLNPNVRKPIYEVFGEDLSNLGNMFFI
                     EPLEYLSFVYLMEKSTIVLTDSGGIQEEAPGLGKPVLVMRDTTERPEALEAGTVKLVGT
                     NYDKIVKEVSALLDNKAHYEEMSKAVNPYGDGTACVRIVNILE"
     CDS             5001..6302
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: CTP_transf_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: PEP_mutase"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: phosphonates"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1231:carboxyvinyl-carboxyphosphonate (Score: 220.3;
                     E-value: 5.2e-67)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_41"
                     /sec_met_domain="CTP_transf_like (E-value: 4.6e-12,
                     bitscore: 37.9, seeds: 65, tool: rule-based-clusters)"
                     /sec_met_domain="phosphonates (E-value: 1.5e-121, bitscore:
                     396.4, seeds: 8, tool: rule-based-clusters)"
                     /sec_met_domain="PEP_mutase (E-value: 1e-64, bitscore:
                     209.8, seeds: 69, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKQIYIGMTADIMHPGLINIINEATKFGDVIVGLLTDKAIAEHK
                     RLPYLTYEQRKKIVENIKGVSKVVPQEEWSYINNLKRLKPDYIIHGDDWKTGVLCEIRE
                     QVYDVMNKQGGTVIEIPYTQGINSSSLNRDIKSIGTTPDVRMKTLRRLINAKSIVRILE
                     AHDGLCGLIIENLEIQKGDRLEVFDGMWSSSLTDSTSKGKPDIEAVDLTTRLQDLNNIL
                     ECTTKPIIFDGDTGGKIEHFVFTVRTLERHGISAVIIEDKIGLKKNSLFGTDAIQTQDT
                     IEGFCNKIKAGKEAQVTNDFMIIARIESFIAGKSMCDALERAYAYVEAGADGIMIHSKN
                     KSGEDIKEFCITFRQKYAHVPIVVVPTTYDHIYESELHTWGVNVVIYANHMLRAAYPAM
                     LQVAKTILENERAKEVRPLCMPIKEILELIPGTK"
     CDS             6669..7442
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: TPP_enzyme_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1055:pyruvate oxidase/decarboxylase (Score: 62.8;
                     E-value: 4.3e-19)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_42"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.1e-21, bitscore:
                     68.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLDLLNAMQIPFVILNAEEDKALRQIHDIIISAKDKSIPHAIII
                     RKNIFGKYKLLNEQKNDCPLSREEALKLVVDYLEATDLVVSTTGKLSRELFEYREAEGE
                     GHECDFLTVGSMGHSSSIALGIALANSERRVFCLDGDGAFIMHMGAIGNIGYLSPKNYF
                     HILFNNGSHESVGGQPTIGFQLDIPAIAKACGYRTVFSLTTKDEIKEILQQTKIMEGPV
                     LIELKVKVASRDDLGRPTTTPLENKFHFMEFLKNK"
     CDS             7447..8565
                     /NRPS_PKS="Domain: Aminotran_5 (31-334). E-value: 3.5e-31.
                     Score: 100.3. Matches aSDomain:
                     nrpspksdomains_ctg32_43_Aminotran_5.1"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_1_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1139:aminotransferase class V (Score: 67.4; E-value:
                     1.8e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_43"
                     /sec_met_domain="Aminotran_1_2 (E-value: 5e-07, bitscore:
                     20.7, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 3.9e-29, bitscore:
                     93.2, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQIKRNILLNPGPATTTDTVKMAQVVPDICPREKEFVGMMKTLRT
                     NLLKVAHGIPGKHTAVLFCGSGTINIDVCLNSLLPKDKKVLIINNGAYSDRAVEVCRYY
                     GLSHINLRFSVYERPDLHEIESILKKDSDIFLVYTTHHETGTGLLNPIREIGALAHRYG
                     CVFITDTTSSLGMIPFDIEKDNVDFCMASAQKGLQSMTGLSFIVGNEEIICKSKEYPKR
                     SYYCNLYMQYEYFEKTGEMHFTPPVQTIYATCQALKEYFEEGEENKFARHRRVFDAIHS
                     GIEELGFKYVIDKQWQSGLVVSVLYPNHPNWNFDKVHNYCYERGFTIYPGKITTTNTFR
                     LCALGAIDESDIKSFFSVLKDALEHFNINVFY"
     aSDomain        7540..8448
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg32_43_Aminotran_5.1"
                     /evalue="3.50E-31"
                     /label="ctg32_43_Aminotran_5.1"
                     /locus_tag="ctg32_43"
                     /protein_end="334"
                     /protein_start="31"
                     /score="100.3"
                     /tool="antismash"
                     /translation="REKEFVGMMKTLRTNLLKVAHGIPGKHTAVLFCGSGTINIDVCLN
                     SLLPKDKKVLIINNGAYSDRAVEVCRYYGLSHINLRFSVYERPDLHEIESILKKDSDIF
                     LVYTTHHETGTGLLNPIREIGALAHRYGCVFITDTTSSLGMIPFDIEKDNVDFCMASAQ
                     KGLQSMTGLSFIVGNEEIICKSKEYPKRSYYCNLYMQYEYFEKTGEMHFTPPVQTIYAT
                     CQALKEYFEEGEENKFARHRRVFDAIHSGIEELGFKYVIDKQWQSGLVVSVLYPNHPNW
                     NFDKVHNYCYERGFTIYPGKIT"
     CDS             8578..9288
                     /gene_functions="biosynthetic (rule-based-clusters)
                     phosphonate: NTP_transf_3"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_44"
                     /sec_met_domain="NTP_transf_3 (E-value: 2.2e-16, bitscore:
                     52.1, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIKTAVIMAAGMGTRFGKYTEQIPKGFVEVCGKPMIERSIETLIS
                     CGIERIVIGTGYKHEVYDFLKKKYPMIETCFSPLYAETNSMYTLYNTQGLIGSDDFLLL
                     ESDLVFETKAITELMNCGKPDVMLATPITKFQDQYYVEFDTKHHLTACSTQKENLNVKG
                     ELVGIHKISSTFFKEMCKDYGRILSEQPKLGYEYELLRISMSTLPLFVLVVEGLKWYEI
                     DDLMDLAYAEIFFK"
     CDS             9349..10653
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_45"
                     /sec_met_domain="Polysacc_synt (E-value: 1.8e-28, bitscore:
                     91.3, seeds: 31, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGLKIIHNVLAKGGLTIFNLILPLAVMPYIYRVLDPHDLGMIEYA
                     TAIVTYFSIFGMLGIYNYGLREMSSIRNNLNSCAFLYRQLFTIGVLSNIFSATCLLLLS
                     FFMDKLVKDIVYIQLLLIVSQIFYVEWVNEAFERYSFITLKTILVRGLGYLSIFGLVTS
                     SNDYKTYVWILSITVFINXXXXYLYVKKKLPIESVQVDWNFIKKIIFALFLILLLNNTN
                     LLYTLLDRFMLGLKSDIYVAYYGVGQKLSDMLKAFLTIVVVVTIPRMSLQLNQNKERYL
                     ENINHLISFLFLLTLPIASLFFCLSKEIVILFAGENYLEAIPSLKIFAIRIVVIVLEAV
                     LYNQIIFLYRREKDLLKLNALCGCLNLGLNGVLYSFLNPFLAILTTLVSELVFQILCIY
                     YIRTKIGLYITYAKKSHLLYLLLSILFPLWIYVIHL"
ORIGIN
        1 tctcgtaacg gatcttacat tcaaaccatg tatgcattgc cataattttc tgtttttaat
       61 tattgattta ttgttagtta agctgcttta tgcgtgccta tgcccgccaa aagcagtgca
      121 aagatagcca aaaactaaat ggatataaaa agttgccttg cattttatgt gaaaatttta
      181 ttggagaacc gggacggtac gtatgggcat aaaaaaagga gtaccgctgt actccaacct
      241 ttgttaacct taaatctaat actatgaaaa acacattgca aaggtacgga ctttttcgac
      301 atttgcaaga gtaacggggt ataaagtgtg tatttataac acttattata tattatgtct
      361 ttatactaca tcttttttaa aacttgagtg gtggtgctga aacataaatt tgcatctgct
      421 ttgcttccac acttccaccc gcctcctgca tctccctatc catcggcatt taccctgcgg
      481 tggaagcaac ctgaaaaggt ggaagcaaaa tttgcttcca cctgccgaaa acgtctgagt
      541 tttgtcgtaa cttattgttc tttaatataa taccgcgcgt gggttacata aatcggtcag
      601 tgtagttttc ctgcattttc gagtttgccc gactatgaat agtggagtct gatgtctttt
      661 aagttgctgt acaatacgtt tgcaccttgt gcgcaatagg cgcgggctac gtacttcatc
      721 tgtaaaagcc ttggagttag tgacgcctaa cggccatgaa caaccctgct tatggtcgtt
      781 aaacgattgc ttcatggcca ttagcagggt tgttcatggc cgttaggcgt cactaactcc
      841 ttatgcaaca gtagaccaag caagggtgaa aagcaaagga atgcttgtgt tttagataga
      901 aatccatggg ctttcactct ctccataggt tatggaagtg ggcttttatt tcacttgcgt
      961 tctgtgcgat aaattcccat ttatcagtag gtatatttac gaaacttcaa taatacattt
     1021 atgagggtaa gatattggaa tgtagaatga tatattggaa atgatgaggt gttttttaaa
     1081 cgttcgttta atggacgcaa agataagccg tattttttga actaacaaaa tgtttaataa
     1141 aaatattccc aaagtgattt ctgttttata ttaatatgtt gaattgcagc attgtacgtc
     1201 taatatttaa catattaaag ttctgttcct ttttaacttt tatgcctcta cttattttct
     1261 taaaaataga cgtttattaa acgaacgttt attggacact tttatgagtc taatatcttc
     1321 tttaatagct tattatcatt gcaaaagtgt acaatacggt ttgggtggga aaatgtctcg
     1381 ttcaaaccgc gaagcgcacc cggaactgag ctgattcatt cgaaagaaaa ttcctaagtg
     1441 actgaacaac agaaatattg gtttgcagcc cgcacccgtg acaagcagga attcacagtc
     1501 cggaaatctc tggaccgact taaatcggaa gaacatttgg accttgacta ttatcttccc
     1561 acgcgttttg tcatttcaca attgaagtat cgccgtaagc gtagcgaagt tccagtaatc
     1621 cgtaatttgg tgtttgttca ttccaccaag cagacagcct gcgatatttc caacatttat
     1681 aatgtccccc ttttttatat gaaggatctt gccacgcatt ccatgctagt ggtaccggat
     1741 aagcaaatgg aggactttat gttcgtaatg gatttgaacc ctgacggtgt cagccttgat
     1801 agcgaaattc ttactgttgg gcataaagta aaagttatca aaggcgaact cagcggtatt
     1861 gaaggtgagg ttgccatcga agccaataaa acatacgtcg ttatccgtat taaagacctt
     1921 ttgacggcaa gtatcaaagt ccccaaatcc tatctgaaaa taatcgggtg acttctaaat
     1981 aagtataatc ttatattttt atcatatatc ataataatga atgatttaac ttcccgtgct
     2041 cttgagcttc agcatgcagc tcatgagctg atgtatcttg gtatggacgg tgagccggtc
     2101 tattccgaca atttttgccg gttgaataag gaagtgcttg ttaagtccga ttctcttttt
     2161 tctgctcaaa gttccgatgt tgaggaagag gcgaatttgt gtctggctct tttgatggga
     2221 tataatgcta ctatttatga tgatggggat aaggagcaaa agaaacaaat ggtattgaat
     2281 cggatttgtc ttgttttgga gcagttgcct gcttctttgc ttaaagtccg tttactaact
     2341 tattgttatg gggaaattta tgaggaagtt ttgcttcagg aagctcatgc gattattgaa
     2401 ggttggaata gagatgaatt gactttggaa caaactgaaa tcattgaaga attgaaaaat
     2461 atcgaagaga atccataccc gtttgaggaa gtagaatagg atttgagtgt gataaagaaa
     2521 tcataaaaaa tagataactt ttattgatat gaaagcatgt tttatggggt tgggttatat
     2581 tggcctgcct actgcgatta ttgctgctaa acacggaatt cagattatcg gggttgatat
     2641 taatcccaaa gttgtagaaa tgactaatca gggtaagttg catatcattg aaccaggtat
     2701 gcaggagctt cttcaagaag tcgttactac cggtcagttg aaggcttcaa caactccaga
     2761 agtgagtgat gcctatttta tggtggtacc tactcctttt aagggaaatc atgagcctga
     2821 tatttcttac gtggaagctg ctacccgtgc cgtaattcct ttgttgaaag agggagattt
     2881 gtatgtcata gaatctacat caccggtagg tactactgat aaaatgtgtg atttgatatt
     2941 tggattacgt ccggaattga gagataaaat ttatattgct tattgtccgg agcgtgttct
     3001 tcctgggaac gtcatttatg agttagttca taatgaccgg gtcattggcg gtttgaatga
     3061 agcttctaca gatagggcta ctgagtttta tagtaagttt gtacgaggaa cgctccatcg
     3121 cactaattgt aaaacggcag aaatgtgtaa actgacagaa aactcctccc gtgatgtaca
     3181 gatagctttt gccaatgaac tctctctgat ttgtgataaa gcaggaatca atgtctggga
     3241 attgattaac ttggcgaaca agcatccccg tgtgaatatc cttcaacctg gttgtggtgt
     3301 tggaggacac tgtatagcgg ttgatcctta ttttattacg gctgaatttc ctatggaatc
     3361 taaaatcata tctaccgctc gtgaaatcaa taactataaa gcattctggt gtgcagagaa
     3421 agtgcagaat gctatgttga agtttgaatt ggaatatcat cgtaaaccta ccattgccat
     3481 gatgggattg gcctttaaac ccgatattga tgatttgcgt gaagctcctg ccaagtatat
     3541 tactactaaa gtgatgcaaa gctgtaataa tgcagatatt ttagtagtgg aacctaatgt
     3601 gcaggaacac aatgtattta aacttacaga ttataaagaa gcctatgaga aggctgatat
     3661 cgtcgttttt ctggttgctc attctgtatt taaatccctg ccatataatg atcggaaagt
     3721 aattcttgac ttttgcggaa tttacaagaa ataataaata gcttatagca tgaagaagat
     3781 tatgttggtt ttcgggactc gtcccgaagc cataaagatg gctcctctgg tgaaagaatt
     3841 tcagaaatat ccggaggagt tcaagacaat cgtatgtgtt accggtcagc atcgcgaaat
     3901 gcttgatcag gtattgcata tatttgaaat cattcctgat tatgatttga atattatgaa
     3961 accaggacag gatttgtatg atgtgacagc tcgtgttttg ataggtatgc gtgatgtttt
     4021 gaaagaggta cagccagatg ttgttttggt tcatggtgat acaaccactt ctacggcttc
     4081 ggcattggct gctttttatc agcagattcc agtgggacat gtagaggcgg gacttcgaac
     4141 tcataatata tatagccctt ggccggagga gatgaatcga gtgataacag ggcgtattgc
     4201 cagttatcat ttctctccaa ctcctttgag tcgtcagaat ctgttggatg aaggtgtaag
     4261 ggaatcagct ataacagtga ctggtaatac agtaatagat gcactttaca tggttgtaga
     4321 taagataaag agtgataaga ggcttgatga agagctgaaa ggcattttga aaactgccgg
     4381 ttatgacatc aaccgcttgt tagatggaaa aaaattagtc ttgataacag gtcatcgtcg
     4441 tgaaaatttc ggtgacggat ttgtttctat gtgccgggct attcagactc ttacaaagaa
     4501 atatccaaat gttgattttg tctatccgat gcatttaaat cccaatgttc gtaaaccaat
     4561 ttatgaggta tttggcgaag atttatccaa tttagggaat atgttcttca tagagccttt
     4621 agagtatctt tcttttgttt atctgatgga gaaatccact atagttttga cagatagcgg
     4681 tggtattcag gaagaagctc ccggacttgg gaagccggta cttgtaatgc gtgatacgac
     4741 agaacgtccg gaagcgctgg aagctggaac ggtgaaattg gtgggaacaa attatgataa
     4801 aattgtaaag gaggtctctg ctctattgga taataaggca cattatgagg agatgagcaa
     4861 ggcggtgaat ccttatggag acgggacggc atgtgttcgt attgtaaata ttttagaatg
     4921 aaataattct aattagaata ttattgaaat tgaatttttg cgtctgagag ataatgtatt
     4981 atttgtataa atagataaaa atgaataaac aaatttacat agggatgact gctgatatca
     5041 tgcatcccgg cttgattaat ataattaatg aggctacaaa atttggtgat gtaatagtag
     5101 ggcttctaac agataaagct attgctgaac acaaacgttt accttatttg acttatgaac
     5161 agcgtaaaaa aattgttgag aatatcaaag gggtttctaa agttgttcct caagaagagt
     5221 ggagctatat caataatttg aaacgtttga aaccagatta tataattcat ggcgatgatt
     5281 ggaagacggg agttctgtgt gaaatccgag aacaagttta tgatgtgatg aataaacaag
     5341 gtgggacagt gatagaaata ccttatacac aagggataaa ttcttcttca ttaaatagag
     5401 atattaagtc tattggtact actcctgatg tgcgaatgaa gactcttcgt cgtttgataa
     5461 atgccaagtc tatagtgcgt atattggaag ctcatgatgg cttatgtggc ttaattatcg
     5521 aaaacctgga aattcaaaaa ggtgaccgtt tggaggtttt tgatggtatg tggtccagta
     5581 gcttaacaga ctcaacgagc aaaggtaaac ctgatattga ggctgtagat ttaactactc
     5641 gtcttcagga tttgaataat atattggaat gtactactaa gcctattatt ttcgatggcg
     5701 atacaggagg caaaattgaa cattttgtgt ttacggttcg tactttagaa cgtcatggaa
     5761 tttctgctgt aattatagaa gataaaatag gcttgaaaaa aaattcactt tttggaaccg
     5821 atgcaattca aacgcaagat acaattgaag gtttttgtaa caaaattaag gcgggaaaag
     5881 aagcgcaagt gaccaatgat tttatgataa ttgctcgtat tgagagtttt atagccggta
     5941 aatctatgtg tgatgctctt gaacgcgcgt atgcttatgt agaggctggt gctgatggca
     6001 taatgatcca tagtaaaaat aagtcaggtg aagatataaa agaattctgt ataactttcc
     6061 gtcagaaata tgctcatgtc cctattgttg ttgttcccac tacttacgac catatttatg
     6121 aaagtgaatt gcatacgtgg ggggtaaatg tggttatcta tgctaatcat atgcttcgtg
     6181 ctgcatatcc tgcaatgctg caggtggcaa aaactatttt agagaatgag cgtgcgaaag
     6241 aggtgcgtcc tttgtgtatg cctattaaag aaatattgga acttattcca ggaactaaat
     6301 aaatagatta tatggtaaac gttgagaaag tatatcatgc tcttttagca aacggaattg
     6361 atttttttac aggagttcca gattcgctct taaaagatat ttgtgcgtat ataacggatc
     6421 atacttttaa ggagcaacat gttatcgctg ccaatgaagg tacagctgtc agtattgcag
     6481 caggacatta tttagcctca ggaaatttgt ctttggttta catgcaaaat tcgggaatag
     6541 gtaatgcggt aaatcctttg ctttcacttg cagataaaaa ggtttatagc ttaccgataa
     6601 ttttaatgat tggttggcgt ggagagcctg gagtaaaaga tgaaccacag catgaaaaac
     6661 aaggtgaagt gactttggac ttgttgaatg caatgcaaat tccttttgta attcttaatg
     6721 cagaagagga taaagcattg aggcagatac atgatattat tatttctgct aaagataaat
     6781 ccattcctca tgcaattata attcgaaaaa atatatttgg aaaatataaa cttctaaatg
     6841 aacaaaaaaa tgattgtcct ttatcccgtg aagaagccct aaaattagtt gttgattatt
     6901 tggaagctac agatttagta gtatctacta caggtaagtt gtctcgtgaa ttgtttgaat
     6961 atcgtgaagc agaaggagag gggcatgaat gcgattttct tactgtaggt tcaatggggc
     7021 atagctcttc tattgcttta ggtatagcac ttgctaattc agagagaaga gttttctgtt
     7081 tagatggtga tggcgctttt attatgcaca tgggagctat tggcaatatt ggctatttgt
     7141 ctcccaaaaa ctattttcat attctgttca acaatggttc gcatgaatct gttggtggtc
     7201 aacctacaat aggttttcaa ttagatatac cggctattgc aaaggcatgt ggatatcgaa
     7261 ctgttttttc gcttacgaca aaggatgaga taaaggagat tttgcagcaa acaaagataa
     7321 tggaaggacc ggttttgatc gaattgaaag taaaagttgc ttctcgtgat gatttaggaa
     7381 ggcctacgac tacgcctctt gaaaataagt ttcattttat ggagttctta aaaaataaat
     7441 aagtatatgc agattaaaag aaatattttg ttgaatccag ggcctgctac gaccactgat
     7501 actgtgaaaa tggctcaggt tgttcctgat atttgtcctc gtgagaagga gtttgtagga
     7561 atgatgaaaa cattgcgaac aaatttgtta aaagttgccc atggtatacc tggtaaacat
     7621 actgctgttt tgttttgtgg ctcaggtact attaatattg atgtttgctt gaactctttg
     7681 ttacctaagg ataaaaaagt gctgattatc aataatggtg cttatagtga tcgtgctgtg
     7741 gaagtttgtc gatattatgg tttatctcat attaatttga gattctcggt gtatgaacgt
     7801 cctgatctgc atgagattga atccatatta aaaaaggatt ctgatatctt tttagtttat
     7861 acaactcacc atgaaactgg cactggtttg ttgaatccta ttcgtgagat tggtgcactt
     7921 gctcaccgtt atggttgtgt atttataaca gatacgactt cttccttagg tatgattcct
     7981 tttgatatag agaaagataa tgttgatttt tgtatggctt ctgcccagaa aggattacaa
     8041 tcgatgacgg gactttcttt tatagttggc aatgaagaga ttatatgtaa gtcaaaagaa
     8101 tatcctaaac gttcttatta ttgtaatctt tatatgcaat atgaatattt tgagaaaacg
     8161 ggtgaaatgc attttactcc tcctgttcag acaatctatg ctacttgcca agccttgaaa
     8221 gagtattttg aagagggcga agagaataaa tttgcacgac atcgaagggt gtttgatgcg
     8281 attcattctg gcatagaaga attaggtttt aaatatgtta ttgataagca atggcaatca
     8341 gggctggttg tgtctgttct ttatcctaat catccaaatt ggaattttga caaagtacat
     8401 aattattgtt atgaacgtgg ttttaccatt tatccgggaa aaataactac aacaaatact
     8461 tttcgacttt gtgcattagg agcaatagat gaatcggata ttaagtcttt tttttctgtt
     8521 ttgaaagatg ctttagaaca ttttaatatc aatgtatttt attaaaacca tattggaatg
     8581 ataaagacag cagtaattat ggcagcaggt atgggaactc gttttgggaa atatacagaa
     8641 cagattccta aaggatttgt tgaagtgtgt ggtaaaccaa tgatagaacg tagtattgaa
     8701 actttaatat cttgtggaat agaacgtatt gtaattggca caggatataa acacgaagtt
     8761 tatgattttc taaaaaagaa atatcctatg attgaaactt gctttagtcc tctttatgct
     8821 gaaactaata gtatgtatac actttataat actcaaggac ttataggtag tgatgatttc
     8881 ttattattag aatcggattt agtatttgaa acgaaggcta ttactgaatt gatgaattgt
     8941 ggaaaacctg atgtcatgtt agcaactcct attacaaaat ttcaagacca atattatgtg
     9001 gaatttgata caaaacatca tctgacagct tgttctactc aaaaagagaa tctgaatgta
     9061 aaaggtgaat tggtaggaat tcataaaata tctagcactt ttttcaaaga aatgtgtaaa
     9121 gattatggcc ggattctttc tgaacagcct aaacttggat atgaatatga actacttcgt
     9181 atttcaatga gtacattacc tctctttgtt ttagttgtag agggattgaa atggtatgaa
     9241 attgatgatc tgatggattt agcttatgct gaaatatttt ttaaatagaa tctttagaag
     9301 gtccatagat gttactttgt tgaatataga taactgttca tatttaacat gggtttgaaa
     9361 attattcata atgttttggc aaagggggga ttgacaattt ttaatttaat acttccttta
     9421 gctgttatgc cttacatata tagggtgttg gatcctcatg atttgggaat gatagaatat
     9481 gcgacagcta ttgttactta tttttcaata tttggaatgt tgggaatata taattatggc
     9541 ttacgtgaaa tgagctcgat tcgtaacaat ttaaactcat gcgctttctt gtatagacaa
     9601 ttatttacga ttggagttct gtcaaatata ttttcggcaa catgtctgtt gctattgtct
     9661 tttttcatgg ataaattagt aaaagatatt gtttatatac aattactgct aattgtttct
     9721 cagatttttt atgtagaatg ggttaatgag gcgtttgaaa gatattcttt cataacattg
     9781 aagacgatac tggtacgtgg cctaggatat ttgtctatat ttggattagt aacatcatcg
     9841 aatgattata agacatatgt ttggatattg tctatcacag tttttattaa tnnnnnnnnn
     9901 ngctatttat atgtaaaaaa gaaattacct atagaatctg tacaagttga ctggaatttt
     9961 ataaaaaaga taatatttgc tttattcttg atattattat tgaataatac aaatttgctt
    10021 tatacattat tagaccgatt tatgttgggg cttaaaagtg atatatatgt ggcatattat
    10081 ggtgtcgggc agaagctttc agacatgtta aaagcttttt taacaattgt agtagttgtt
    10141 actataccta gaatgtctct acaattaaat caaaataaag aaagatattt ggagaatata
    10201 aatcatttga taagtttttt atttttatta actttaccaa ttgcctcttt atttttttgc
    10261 ttatcaaaag agattgttat attatttgct ggtgaaaatt atttagaggc tattccatct
    10321 ttaaagatat ttgcaatacg aattgtggtt attgtcttgg aagctgtttt gtataatcaa
    10381 ataatatttt tatatcgtcg tgagaaagat ttactcaagt taaatgcttt atgtggatgt
    10441 cttaatttag ggttaaatgg tgttttatat tcattcttga atccctttct ggcaatattg
    10501 acaacattgg taagtgaact tgtttttcag atattgtgta tatattatat aagaacaaaa
    10561 ataggattgt atattactta tgcaaagaaa tcgcatttgt tatatttatt gttatctata
    10621 ttattccctt tatggattta tgtaattcat ttgt
//
