LOCUS       gnlProkkaHHNNJJGG_18   12916 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HHNNJJGG_18.
ACCESSION   gnlProkkaHHNNJJGG_18
VERSION     gnlProkkaHHNNJJGG_18
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 03:20:54
            Original ID  :: gnl|Prokka|HHNNJJGG_18
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12916
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12916
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1359:2916]"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      1360..2916
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /neighbourhood="10000"
                     /product="ranthipeptide"
                     /protocluster_number="1"
     cand_cluster    1..12916
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TIGR03973 or SCIFF or (cds(PF04055 and
                     (TIGR04085 or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /kind="single"
                     /product="ranthipeptide"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12916
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="ranthipeptide"
                     /region_number="1"
                     /rules="(TIGR03973 or SCIFF or (cds(PF04055 and (TIGR04085
                     or SPASM)) and minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE]) and not (TIGR01716
                     or subtilosin or TIGR02111 or TIGR03966 or TIGR04103 or
                     (YcaO or TIGR03604))))"
                     /tool="antismash"
     CDS             88..1122
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_1"
                     /sec_met_domain="TIGR04085 (E-value: 8.1e-11, bitscore:
                     34.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 1.9e-07, bitscore: 23.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLKTAKKAVDFYFKNSNNCNHQISFIGGEPLLKFNLIKKIVEYI
                     KTFNNKVSFTIITNGSLLKEDILNYLIENMFHITISFDGEKEIQGLNRLSKDKKNSFDI
                     VYNNIRKIQLNNTRYFEQYVTINSVYSINITSSLSEFTNYLEAHFKNKFAINIQSSEIN
                     DEYTKFHNNFTKSFLSIYENIHIQGFENSSPPLFIISSDLHKKMMFFSRRSNNILQEET
                     RFIPIKSCLPYLNKIYISPTGDIFMCSDLYYIKGFNIGNIDKSIELNKLQDIMTQYTNF
                     RNKTCKKCWVYRFCDFCFYTLYASKERKGINKYCKIIKYDYAQVIKSYIKILKSNGSAF
                     DIYY"
     CDS             1360..2916
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: PF04055"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     ranthipeptide: TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_2"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 4.8e-08,
                     bitscore: 25.2, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.5e-15, bitscore: 49.9,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 9.3e-10, bitscore: 31.0,
                     seeds: 84, tool: rule-based-clusters)"
                     /sec_met_domain="TIGR04085 (E-value: 7.7e-09, bitscore:
                     27.9, seeds: 281, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKLEYKNSPVLGFILNSKYYLYDRYSNSIFTVPRIFFEYLDDLI
                     SLDTDEFTQKYHNIFSKEEIIDLFKTLDYCQNDKKLIKPNRIPKFTISSIYSNAKKVEK
                     KLKKELTFLCINITEECNLRCEYCIFSGKYTKSRRHNSNNQIEWNYIEKGVNLFLEHST
                     DSNIRKIGFYGGEPLLYFDIIRKTINYVRSKCDNAIFTITTNATLLKDKILSFFVENNV
                     EITISLDGPQNIHDKNRIFPNGVGSFNTVIKNIESIKRLHHDFFENNIKFSATLSPGKY
                     KIKDLIDFFTYDMFPTLKRADLPLSLNYINYEENKYLSEVKYLDWTKKTENEIFKLYRK
                     IHIKGINKTSEIPAVLRALPIHREMMYINLRSNIAFDEFKFFWPNGACIPGMRSIFLNS
                     KGIFLPCEKLNSETEFCIGDVSTGFDIKKISQLIADYSREIAPLCSNCWAFRFCGECWT
                     TAVKNGQISKDFRSQYCSYIKSYWARRLFLYTEIIEKNPKAFSYQGSIDYPEFMSHMIN
                     E"
     CDS             2929..4056
                     /locus_tag="ctg18_3"
                     /transl_table=11
                     /translation="MNKYITYLFLLLLSCGKPQDNNGIFTMDLSKDDLPKTTVSLDDYT
                     TKWTRIDLETTEDCLLDPSFNIYPTDHFIVAYSFNRILVFDHTGHFIREISHFGEGPDE
                     HGLLFNCTVNPTSEQLVFVEMGNTEEIIRYDLSSGKQLTAIPIVAKKQLCDLLFIKDST
                     LVCFPYAGNQKQMAYKQNLAGEWIGTPPIPISEPAGPYNPIPISLFQVDNQWIYKGIYE
                     DTLYLVNNLEPFARFSRKDISPSKTELEVQNSSFINHLFTSNGMSLFGYPQYQLKEVSE
                     GIFDLVLVDFRAFLFNHADKQILEIEKMNCPPLSIIYEQKNLNDLFMLISSRNPKKLVL
                     KVPAEFMGKEEDENPVLFISDLIYPKKKQPTRGKP"
     CDS             complement(4219..6723)
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="MRSIMSKWGKHIAAIAVFLVLTVIYFSPAVFEGKVVRQGDTEKAI
                     GMGNSQMDEYEKTAQPGEFSAWSDAMFGGMPYVSGYGNPAPRFPGYLLVEKPLKALGYM
                     DAGMVFTGFVCFYILMCVMGVNWWLAIAGAIAFALASYNLIIIEAGHVTKAYVIAYMPL
                     TLAGMALLFKRKYLWGAVVFLLGVAFSIANTHLQITYYLLLLCFFVYLGYLFNKLKEKA
                     YKELGTVTAIMAGCVILAVLPNAQNMYAQWDLGQNSIRGATELTTTTPSGEKISSGLDK
                     DYAFAWSYGKGELLTLLVPNAYGGSSGGMLGPDSELYKELRAKGAQVGKEVQAPTYWGE
                     KTFTSGPVYFGALVCFLFVLGMFVIRNPMKWWLFGGSVFLILLALGRNFDSFNDFMFHY
                     LPMYNKFRTVEMALVIPGMVFPIIAIWGLKEVLSETVSDALLKKGLIAALAITGGISLI
                     LWLMPSMLLDFRSSFDAQYQLPDWYYNALLMDRASLASADALRSLVFILLGAALLFWFY
                     TSKDRKKVATFVGIGVAVLMLVDLWTVDKRYLNDSNFIRQKPTEVYKETVADQEIMKDK
                     DLSYRVLNLNNPFLETTTSYYHHSVGGYYAAKLRRYQELIDHRLQGELNSVIEAFQKAQ
                     IAEDLMGAFAACPSLNMLNTRYIIYNPEQPPLRNPFAFGNAWFVDKVEVVENADAEIAA
                     LNTINPLTTAVVDKRFADEVKGFTPQLDSTATITLDSYRPNKLVYTTKTNSEQLAVFSE
                     IYYQPGWEATIDGKPAPHFRADWILRAMLVPAGEHQIVFEFRPQGYITAAYITSFSSLI
                     ILLLLIGAIGYSIWRAKKDKTA"
     CDS             complement(6747..7514)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_5"
                     /sec_met_domain="Glycos_transf_2 (E-value: 3.1e-30,
                     bitscore: 97.3, seeds: 256, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEMNQQPTFSIITITYNAERWLERTILSVLSQSYPNIEYILIDGA
                     SKDKTVEIIKQYESGIASWISEPDKGLYDAMNKGLKRATGDYVWFLNAGDTLYTADTVQ
                     RIVASLKKKVSLPDVIYGETQIVDAEGRSLGMRRLKAPEKLTWKSFRMGMLVCHQSFIS
                     KREIAPLYNTEYRLTADYDWCIQCLRRSKRIHNTRLTLSNFLEEGLSSVNRKASLKERY
                     EVMCKYYGKVSTILLHGWFAVRFYFAKWFKGRV"
     CDS             complement(7521..9383)
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="MDDQHKPEWIKVDEWDFVEYVDSLLRSQEAVDLEFKTARAGFPNS
                     VWETYSSFANTDGGTIVLGIKEKNGALFVEGLLPEQIVSYRQIICNQLNNPDCVNVNLL
                     TDKNIQEVDYRGKSLLLIYVPRASRSQRPVYLTRNPLNGHTYKRNNEGDYKCTDTEVRR
                     MIADADEEHPRDSRILCNYSMEDIDLDSLKQYRLLLSSRQPDHPWLTLDDMAFLRKLGG
                     YRQDRQTGQEGFTLAGILMFGRTESITDNECAPSYFPDYQEKMSVDENVRWTDRICMDG
                     TWEANLFQFYRRVYPKLSSVLPKPFRLENGVRLEDTTTHVALREAFVNTLVHCDYMEEG
                     NITIEQWKDRYVFKNPGTLLVSKAQYYAGGESICRNKSLQKMFMLIGFSEKAGSGVNKI
                     FMGWKNANWRPPFVEEQSHPDRVVLNLPMESLYPEEVLEELKRLFGREIERIPYDQFTV
                     LALCYSEKQVSNERLQYILNQHSSNITKLLKSMCNAGFLESIGNGRGTRYRLLFLEKDE
                     SKPQKDESKLKKDESKSQKDESKLEKDESKKYMRYEDLSRLILSVCEDYVALEIIAEAV
                     HREASYLINRVIPRMLEDGLLERLYPSSPKHPLQKYRVRQVGNL"
     CDS             complement(9482..10744)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 121.7;
                     E-value: 6.9e-37)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_7"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.1e-25,
                     bitscore: 82.2, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKILILNTSELTGGAAVAANRLAKALGKSGVEVSMLVRDRKTDHV
                     KVFSVNNSWTSHRLNSFRFIWERLIIFICNFFSKKNLFQVSIANTGTDLSKHPLVQQAD
                     VIHLHWVNQGFLSLSDIKKLVNTGKPIVWTMHDLWPATAICHYPGGCEKYISNCYQCPM
                     LKRNPFFDLAASVFKEKGKIGLSKITFVGCSRWIMEEAQKGNWLRTACFTSIPNPIDVT
                     AFKRMEKRVARKRFDLPEGKFLLLFAAAKLSDTRKGAIFLIEACEKLKEKYQDRIEIVL
                     MGNSSEELISQFPFKVNTLGYISDQDSMISVYACADMFVIPSLEDNLPNTIMESMACGT
                     PCVGFETGGIPEMIDHLKNGYVAKYKDTNDLAVGIKWIIDNQETFRFSEACVRKVHDCY
                     RESVIAEKYIALYQSLCNKRK"
     CDS             complement(10741..12072)
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="MEENQHTEFKESWHDEYTRYISAFCNTEGGVLYIGIDDKGEVVGI
                     EQPKKLIEKLPNFIAQKTGIMPLIHLREKAGKEYLEIEVQPSAMPISVHGRYYTRSGSV
                     TSELQGNQLNMFLAAKMGLTWESVIEEDFSLEDIDTDTVERFKLLAKDRVPSIEQETDL
                     LALMERLNLIVGGRFKRAAVVLFGKNVQRYVLQARIKIGKFLTDTEVLTTDIVEGNLIQ
                     QVDRALDILRTKYLLSYISYEGIHRREKLVYPYEALREALLNSIIHREYFVSSEIQVRV
                     YEDKLVIGNEARLHDITVEDLSRPHPSRPHNKLIADVFYKAGFIESWGRGTQRIIDNCL
                     AEGLSAPVYEHKMGFLYLTFFHERINERINERINERINELSDMEREVYQILREEPTIRQ
                     IDLANRLDLTEQYIRKLIKKLKEHGWIERIGARKNGYWKIIEKS"
ORIGIN
        1 aacactaaat attacagaaa cgtgcaactt cagatgcaag tattgtttct ttaacaaaaa
       61 aaaatagaag aatcatactc caaatcaatg tccttaaaaa cagcaaaaaa agcagttgat
      121 ttttatttca aaaacagcaa taattgcaac caccaaatat cattcatagg aggagagcct
      181 ctactcaagt tcaacttaat aaaaaaaatt gttgaataca taaaaacatt caacaacaaa
      241 gtatcattca caatcataac aaatggctct ttattaaaag aagacatatt aaattatcta
      301 attgaaaaca tgtttcatat aactataagt tttgatggag aaaaagaaat tcaaggattg
      361 aacagattat caaaagataa aaaaaacagt tttgatatag tatataacaa tatacgcaaa
      421 atacaactaa acaacacaag atacttcgaa caatatgtaa caataaattc cgtatattca
      481 atcaatataa caagttccct ttccgaattc accaactatc tagaagcaca tttcaaaaat
      541 aaatttgcta taaatattca atcatctgag ataaacgatg aatacacgaa attccataat
      601 aatttcacaa aatccttttt atcaatatat gaaaatatac acatacaagg attcgaaaat
      661 agctcccccc ctttatttat aatttccagc gacttacata aaaagatgat gttcttttca
      721 agaagatcaa acaacatcct gcaagaagaa acaagattta ttcccataaa aagctgcctt
      781 ccttacttaa acaagatata tatatcaccg acaggtgaca ttttcatgtg cagcgattta
      841 tattacataa aaggatttaa tatcggaaat attgataaat ctatagaatt aaacaagcta
      901 caagatataa tgacacaata cactaacttc agaaataaaa catgtaaaaa atgttgggtt
      961 tatagattct gcgatttttg tttttataca ttatatgctt ctaaagaacg aaaaggaata
     1021 aataaatatt gtaaaataat aaaatatgat tacgcccaag tcatcaaatc atatattaag
     1081 atattaaaat caaacgggag tgcgtttgat atatattact aacatataaa attattcagc
     1141 gtatgaaaca aaaaacgaag aaaatctcat gggaaaactt taaagacgag attaaagtaa
     1201 tctctgccgg acagcaaaag ttactcaccg gaggtggatg tgcttgctgc atctgtagcc
     1261 caggtaatgg gaatagcggt ttaggaggct caaccaaagc ttcaatttca cattaataac
     1321 ctgcggggag atttctctcc ccgcataagc tttcacttta tggaaaaact agaatacaaa
     1381 aatagcccag tactaggttt cattttaaat tcaaaatatt acctatacga tagatattcc
     1441 aattccattt ttacagttcc aagaatattt tttgagtatt tagacgatct aattagcctt
     1501 gacacagatg aattcactca aaaatatcat aatatttttt caaaagagga gattatagat
     1561 ctatttaaga cattagatta ttgccaaaac gacaaaaaac taataaaacc taatagaata
     1621 cctaaattca ccatttcatc catctattct aacgctaaaa aagtagaaaa gaaactcaaa
     1681 aaagaattaa ccttcctatg cataaatata actgaagaat gtaatctcag atgcgagtac
     1741 tgcatattct ctgggaaata tacgaaatca agaagacata acagcaacaa tcaaatcgag
     1801 tggaattata tagaaaaagg tgttaattta ttcttagaac acagcacaga ctctaatatt
     1861 agaaaaatag gtttctatgg aggcgaacct cttctatatt ttgacataat aagaaaaact
     1921 atcaattatg tccgaagtaa atgtgataac gcaattttca caattaccac aaatgcaact
     1981 ttactaaaag acaaaatttt gtctttcttt gtagaaaata atgtagagat caccattagc
     2041 ctagatggtc ctcaaaacat tcatgataaa aacaggattt ttcctaatgg cgttgggagt
     2101 tttaacaccg tcataaaaaa catagaatct atcaaacgat tacatcatga tttttttgaa
     2161 aataatataa aattctcagc gacattatca cctgggaaat acaaaatcaa agatttaatt
     2221 gactttttta catacgatat gttccctacg ctgaaaagag cagaccttcc attaagtctt
     2281 aattatataa attacgaaga aaataaatat ttaagcgaag taaaatattt agattggaca
     2341 aaaaaaactg aaaacgaaat ttttaagtta tatagaaaaa tccatataaa aggaatcaat
     2401 aaaacttctg aaataccagc agttctaaga gccctaccta ttcatcgaga aatgatgtat
     2461 atcaatttaa gaagtaatat agcttttgat gaatttaagt tcttttggcc taatggagcc
     2521 tgcatacctg ggatgagaag tattttcttg aattctaaag ggatcttttt gccatgcgag
     2581 aaactaaatt cagaaacaga gttttgcata ggtgatgtat caacaggatt tgacataaaa
     2641 aaaatatcac aactcatagc agattactca agagaaatag ctccactatg ttccaactgc
     2701 tgggcattta ggttttgtgg ggaatgctgg acaaccgcag taaagaatgg acaaatatca
     2761 aaagatttta gatcgcaata ttgcagttat ataaaaagtt attgggcaag aaggctattt
     2821 ttgtatacag aaataatcga aaaaaatccc aaagcattct cttatcaagg aagtatagat
     2881 tatcctgaat ttatgtctca catgattaac gaataaacta aaacaaccat gaacaaatac
     2941 attacatatc tattcctttt attattatct tgcggaaagc cccaagataa taacggtata
     3001 ttcacaatgg atctatccaa agatgacctt cccaaaacaa cggtatcatt ggatgattat
     3061 acaaccaaat ggacaaggat agatcttgag actactgaag attgcctact tgatccatcg
     3121 tttaacatct accctacaga tcattttatt gtcgcttatt cctttaatcg aatcctcgta
     3181 ttcgaccata caggacattt tatccgcgag atctcccatt tcggagaagg tcccgacgaa
     3241 catggtcttt tattcaactg tacagtcaat cctacgagtg aacaacttgt cttcgtagaa
     3301 atgggaaata ccgaagaaat aattcgttat gatctatcga gtggcaaaca attgactgcg
     3361 ataccaatcg tcgcaaaaaa gcagttatgt gacttattat ttatcaagga ctctacactt
     3421 gtctgcttcc catacgcagg caatcaaaag caaatggcct acaaacaaaa tctagccggg
     3481 gaatggattg gaacaccccc cattcccatc tccgaaccgg caggtccata taatcccata
     3541 cctatcagtc tatttcaagt ggataatcaa tggatctata aagggatcta cgaagacacg
     3601 ctttacttag tgaataattt agaacctttc gctcgttttt caaggaaaga catcagtcca
     3661 tcaaaaacag aattagaggt acagaacagc tcttttataa atcatctgtt tacctctaac
     3721 ggaatgtcat tattcggata cccgcaatat cagttaaaag aagtatctga aggcatattc
     3781 gatttagttt tagttgattt tcgagccttc ctttttaatc acgcagacaa acaaattctt
     3841 gaaatagaaa aaatgaactg cccacctctg tcaattattt atgaacaaaa aaatttaaat
     3901 gatctattca tgctgatctc ctcccggaac ccgaagaaat tggtactaaa agttccagcg
     3961 gaattcatgg gaaaagaaga agatgaaaac ccagtcttat tcatatccga cttgatatat
     4021 ccaaagaaaa agcagcccac tcgtgggaaa ccctaacgag aaaactgctt ggctttatcc
     4081 ataacgaata atcgttacca atttccacct agttgtagag acggggcgtg ccccgtctca
     4141 tctcctcaaa atggaaactt taaaataccc attagtctgt gccgagacgg ggcacgcccc
     4201 gtctctacaa ctggatattt aggctgtctt gtctttttta gctctccaga tcgagtaacc
     4261 gatcgctcca atcaataaca aaaggattat caatgaacta aatgaggtta tataagccgc
     4321 cgtaatataa ccttgcggtc taaactcaaa tacgatctga tgctctcccg caggaactaa
     4381 catagccctt aatatccaat ccgcccggaa atgaggagcg ggcttcccat caatcgtagc
     4441 ctcccatccc ggttgataat agatctcaga gaatactgct aattgctcag aattagtctt
     4501 cgtcgtataa actaacttat tagggcgata actatccaat gttatcgtag cggtagagtc
     4561 caattgaggc gtgaaacctt tcacctcatc agcgaaacgt ttatcgacaa ccgccgtcgt
     4621 taacggatta atcgtattca acgccgctat ttccgcatcc gcattctcca cgacctccac
     4681 tttatccaca aaccaagcgt tgccgaaagc gaacggattc ctcaaaggcg gttgctccgg
     4741 attatagata atataacgtg tatttagcat attcaaggac gggcaagcag cgaacgcccc
     4801 catcaaatcc tccgcgatct gcgctttctg gaaagcctcg ataaccgagt taagctctcc
     4861 ttgcagacgg tggtcgatca gttcttggta ccgtctcagc ttcgcggcat aataaccacc
     4921 aacggaatgg tgatagtacg aggtcgttgt ctccaagaaa ggattattca aattcaagac
     4981 acgataagaa aggtccttat ccttcatgat ttcttgatcg gctaccgtct ctttatatac
     5041 ctctgtaggt ttctggcgga taaagttact atcgttcaaa taccgtttat ccaccgtcca
     5101 taagtcaacc aacatcaaga ccgcaacacc gatccctacg aatgtcgcca cctttttccg
     5161 atctttcgag gtatagaacc agaacaacaa agccgcccct aataagataa agaccaaaga
     5221 gcgcaacgca tccgccgaag ccaaggaagc acgatccatt aacaaggcgt tgtaatacca
     5281 atctggcaac tgatattgag cgtcgaaaga agaacggaaa tccaacagca tactcggcat
     5341 caaccaaagg attaaagaaa tgccccccgt gatagccaaa gcagcgatca atcctttctt
     5401 caacaaggca tcgctcacgg tctcggataa cacctctttc aatccccata tagcgataat
     5461 aggaaatacc atacccggaa taaccaatgc catctctacg gtacggaact tattatacat
     5521 cggcaagtaa tggaacataa agtcattgaa gctatcaaaa ttacgtccca atgccagcaa
     5581 tatcaaaaag acagaacctc cgaataacca ccatttcatc ggattccgga tcacgaacat
     5641 tcccagaaca aacaagaagc agaccaatgc cccgaaataa accggcccgg aagtaaatgt
     5701 cttctctccc caataggtag gagcctgtac ctcttttccg acttgagcgc ctttcgccct
     5761 taattcctta tatagctcag aatccgggcc tagcattcca cctgaacttc caccataggc
     5821 attcgggacc aacaaggtca acaactcccc ttttccatag ctccaagcga acgcataatc
     5881 cttgtctaag ccggaagaaa tcttctcgcc cgaaggggtc gttgtcgtta attccgtagc
     5941 cccacggata gagttctgtc ccaaatccca ttgagcatac atattctggg cattcggcaa
     6001 caccgccaat atcacgcatc cagccataat agcggttacc gtacccagtt ctttataagc
     6061 tttttccttc agtttattga acaaatatcc caaataaacg aagaagcaaa gtaataataa
     6121 ataataagtg atttgcaggt gcgtattcgc gatagagaat gcgacaccca acaagaacac
     6181 gaccgccccc cataaatact tacgcttgaa caacagggcc atacccgcca acgttaatgg
     6241 catataagcg attacatacg ctttcgtgac atggccggcc tctataatga tcagattata
     6301 agatgctaaa gcgaaagcga tagcaccagc gatcgccaac caccaattta cgcccatgac
     6361 acacatcaag atatagaaac aaacgaatcc ggtaaacacc atccccgcat ccatataccc
     6421 cagcgctttt aaaggcttct ccactaaaag atatccggga aatcgtggag ccggatttcc
     6481 atatcccgac acataaggca ttccgccaaa catagcatca gaccatgcgc tgaattctcc
     6541 cggttgggcc gtcttctcat attcatccat ctggctattc cccataccga tagccttttc
     6601 cgtatcccct tgccggacta ccttaccctc aaatacggcc ggagaaaaat aaatcaccgt
     6661 caataccaag aatacggcta tcgctgcgat atgttttccc catttactca ttatactccg
     6721 cataaaactt atctataatt tattgtttat actctacctt taaaccattt ggcaaaatag
     6781 aatctcacgg cgaaccaacc atgcaacaga atcgtcgaca ccttgccata atacttacac
     6841 atgacctcat atcgctcctt taaggaagct ttccggttca cactacttaa tccttcctct
     6901 aaaaaattag acagggtcaa acgtgtatta tgtattcttt tcgatcgtct cagacattgg
     6961 atacaccaat cataatccgc cgtcaaacgg tattccgtat tatataacgg agcgatctcc
     7021 cgttttgata taaacgactg gtgacaaacc aacattccca tccggaaact tttccaagtc
     7081 agtttctccg gtgctttcaa tctgcgcatc cctaatgatc taccctccgc atcaacgatc
     7141 tgggtctctc cgtaaatcac gtctggcaaa gatactttct ttttcaaaga cgccacaatt
     7201 ctttgcacgg tatctgcggt ataaagtgta tcccccgcat tcaggaacca cacataatcc
     7261 cccgtagccc gcttcaatcc cttattcata gcatcataca agcctttatc aggctcgctt
     7321 atccaagaag cgataccgga ctcatattgc ttgatgatct ctacggtctt atccttcgac
     7381 gctccgtcaa tcaatatata ctcgatattc ggatacgact ggctaagtac gctcaatatc
     7441 gtacgctcca accatcgctc cgcattatag gtgatcgtta tgatcgaaaa tgtaggttgc
     7501 tgattcattt ccattatctc ttataaattt ccgacttgtc tcacacgata tttttgtaaa
     7561 ggatgcttag gagaagacgg atataatctc tctagtagcc catcctctaa cattcttggt
     7621 ataacccgat taattaaata agaagcctct ctatgaacag cttccgctat tatttccaga
     7681 gctacataat cctcacaaac agatagtatt aacctcgaca aatcctcata acgcatatat
     7741 ttcttacttt catccttctc cagtttgctt tcatcttttt gagacttgct ttcatccttc
     7801 ttcagtttgc tttcatcctt ttgaggcttg ctttcatcct tctccaaaaa cagcaaacgg
     7861 tacctagttc cccggccatt tcctatagac tccaaaaaac cagcattgca catacttttt
     7921 agtagctttg taatatttga gctatgttgg ttcaaaatat attgaagtct ttcattagat
     7981 acttgttttt cagagtaaca aagagccaaa accgtgaatt gatcatatgg aattctttca
     8041 atttcccgtc caaacagacg cttaagttct tctaagactt cctctggata caaactttcc
     8101 atcggtaaat tcaacaccac ccgatccggg tgactttgct cctccacaaa tggaggtctc
     8161 caattcgcat ttttccaacc cataaaaatc ttattcaccc cacttcctgc tttctcagag
     8221 aagccaatca gcataaacat cttttgcaag ctcttattac ggcatatact ttcacctccg
     8281 gcataatact gggccttact cactagcagt gttccgggat ttttaaatac ataacgatct
     8341 ttccattgtt ctatcgttat atttccttcc tccatataat cacaatgcac caatgtattt
     8401 acaaatgcct cacgtaaagc gacatgcgtg gtagtatctt ccaatctcac accattctcc
     8461 aaacggaatg gcttaggcag tacagatgat aatttaggat acacacgccg ataaaattga
     8521 aaaagattcg cttcccaagt tccatccata caaatgcgat ctgtccatct aacattctca
     8581 tctaccgaca ttttttcctg ataatccgga aaataagatg gagcacattc attatccgtt
     8641 atactttctg tccttccaaa cattaatata cccgctaaag taaacccttc ttgacctgtt
     8701 tgcctatctt gtcgatatcc tcccaatttt ctcaaaaaag ccatatcatc aagtgtcaac
     8761 caagggtgat ctggctgacg actagaaagt agcagtcgat attgtttaag tgagtccaaa
     8821 tcaatatctt ccattgaata attacataaa atacgagaat ctctcggatg ttcctcatcc
     8881 gcatcggcaa tcattctgcg aacttccgta tccgtacatt tataatctcc ctcattattt
     8941 cgtttataag tatgtccatt caagggattt cttgttaaat atacaggacg ttgtgaacga
     9001 gatgctctcg gaacataaat cagcaaaaga gattttcctc tatagtctac ctcttgaata
     9061 ttcttgtcag taagtaaatt aacattaacg caatccggat tattcaattg gttacaaatg
     9121 atttgccgat aagacacaat ttgctctgga agaagtccct ccacaaatag tgccccattt
     9181 ttctccttta ttcccagaac gatagttcct ccatctgtat tcgcaaatga agaatacgtt
     9241 tcccacacac tatttgggaa tccggcacga gcggtcttaa actctaaatc gacagcctct
     9301 tgactacgca acaagctatc cacatattct acaaaatccc actcgtccac cttaatccat
     9361 tcaggcttat gctgatcgtc catttattcc atttttccac aaatgtagca attttcattt
     9421 gctttcaatc acttaccagc aagcattcat tcttacttcg atatgctgat cttctttcac
     9481 gctattttct cttattacac aggctctgat acaaagctat atatttttcg gcaataaccg
     9541 attccctata gcaatcatgc accttgcgga cgcaagcctc actaaatcga aaagtctctt
     9601 ggttgtcaat tatccactta atccctacag ccaaatcatt tgtatcctta tatttagcta
     9661 catacccatt cttcaaatga tctatcatct ccggaatccc tcctgtctca aatcccacac
     9721 aaggcgtacc gcatgccatc gactccataa tcgtattggg taagttatcc tccaacgaag
     9781 gaataacgaa catatcggca caggcataaa cggaaatcat agagtcttga tccgatatat
     9841 atcccagcgt attcacctta aaaggaaact ggctaatcaa ttcttccgag ctatttccca
     9901 tcaacacgat ttctatgcga tcttggtatt tctcttttag tttttcgcaa gcctcgatca
     9961 aaaaaatcgc tcctttccgg gtatctgaaa gcttagcggc ggcaaaaaga agaaggaact
    10021 taccttccgg caggtcgaat cgtttacggg ccacccgctt ttccatacgc ttaaaggctg
    10081 tcacgtcaat cgggttagga atcgaggtaa aacaggctgt tctcaaccaa ttgccttttt
    10141 gggcctcttc cattatccat cggctacaac cgacaaatgt aatcttagat aaccctattt
    10201 tccctttctc cttaaaaaca gaagccgcta aatcaaaaaa cggatttcgt ttcagcatcg
    10261 ggcactgata acaattcgat atatacttct cacatcctcc cggataatga caaatagccg
    10321 tagctggcca caaatcatgc atagtccaca caataggttt tccggtattt actaatttct
    10381 taatatcaga aagagacaaa aatccttgat tcacccaatg cagatgaatc acatccgcct
    10441 gttgcactaa tgggtgcttc gataaatccg tgcctgtatt ggctatggaa acttgaaaga
    10501 ggttcttctt gctaaagaag ttacagataa agattatcag tcgttcccaa atgaagcgaa
    10561 aagaattaag cctatgtgaa gtccatgaat tatttacaga gaaaactttt acatggtctg
    10621 ttttccgatc acgtactaac atagaaacct ctacaccaga tttacccaat gctttcgcta
    10681 gtcggtttgc ggcgactgcc gctccaccgg ttaattcaga ggtatttaat atcaatatct
    10741 tcatgacttc tctattattt tccaataacc atttttccta gctccaatgc gttcaatcca
    10801 accatgctct ttcaactttt ttataagctt ccggatatac tgctctgtca aatccaaacg
    10861 atttgctaaa tctatttgac ggatagtagg ctcctctcgc aagatctgat atacctcccg
    10921 ttccatatcc gacaattcat ttatccgctc atttatccgc tcatttatcc gctcatttat
    10981 ccgctcatga aaaaaagtca agtataaaaa acccatctta tgctcatata caggagcgga
    11041 taatccttct gccaagcagt tgtcaataat acgttgtgtt ccccgtcccc aactctcgat
    11101 aaagccagct ttgtaaaaaa catccgctat caacttatta tgaggtctag aggggtgagg
    11161 acgagacaag tcctcaaccg taatatcgtg caaacgagct tcattcccta tcaccagctt
    11221 gtcctcgtaa acacgtacct gaatttcgga agaaacaaaa tattctcgat ggataatcga
    11281 attcaataag gcttcccgca gagcctcgta gggataaacc agtttctcac gcctatgaat
    11341 cccctcatac gatatataac ttaataaata tttcgttcgc aatatatcca aagcccgatc
    11401 aacctgctga atcaggttcc cctcgacaat atcggttgtc agtacctccg tatcggtaag
    11461 gaactttcct attttaatac gagcttgtaa cacatatctc tgcacattct ttccaaacaa
    11521 gactacagcg gctctcttga aacggcctcc tacgatcaaa ttcaaccgct ccatcaaagc
    11581 cagcagatcc gtttcctgct cgatggaagg aacccggtct ttagccaata gcttaaaacg
    11641 ttctaccgta tcggtatcta tgtcctccaa tgagaaatcc tcctcgatca cactttccca
    11701 tgtcaaaccc attttcgcag ccaaaaacat atttagctga ttcccttgta gctcggaagt
    11761 aacgcttcca ctccgggtat aataccgtcc atgcacggaa atcggcatgg cagaaggttg
    11821 gacttctatt tccaaatatt ctttaccggc cttctccctc aaatggataa gaggcataat
    11881 acccgttttc tgagcgataa agttcggcag tttctcaatc aacttctttg gctgctctat
    11941 ccctacaact tctcctttat catcgatacc gatatataat acaccaccct ccgtattaca
    12001 gaaagctgat atataacggg tatattcgtc atgccatgac tctttgaatt cggtatgttg
    12061 gttttcttcc ataatctaaa attatatcaa actttttttc taaatatcct ccgaacacaa
    12121 gtatttaatt taactaacaa ggaatatggt aaacaattta aaaacaaatg atagttacaa
    12181 tccaaattca ataatcccca aggcaataaa cgtatatact ccaaaaatgc acttttctta
    12241 tcattatcaa aaacaaagat tacaaatctt atcttgtacc aaagataaac ataattatct
    12301 aagtctttta tctgataaga gcagtttagc ctccaaagct ctataccaac atagtcttct
    12361 tttattgctg gctgcatatt tttcttaaca ctcaaatagc aactgctatc tcttctatac
    12421 aatgctaggt ttgatttcga ataagctatt ttatacaagc aagctaattt agcccaaacg
    12481 attacatctt cacctaaaga aatgccctca gggaaacaac caatagataa aatagccttt
    12541 tttcgaacag ccacagctga agtccaaata ggtcctctcg cttttgaggc catcgtaaaa
    12601 taattatcta aaataccctc attctcttta aaagaataat aatcaattga tgcgggagtt
    12661 atcatattat tcatcttaaa tgaataagct gtaccaaaaa tatcacattc cggatatttt
    12721 tcaaccaaga aagcgatagt ttttaaataa tcaggtaacc actcgtcatc agcatcaaga
    12781 aaggcaataa tctcacctct agcttcttta ataccttggt tcctcgctgc agaaacacct
    12841 ttgttctcct gttcaatcaa tcgaactgaa tttttaaaca cagcttcatt ttctgaaaga
    12901 aaatccatca aaacag
//
