LOCUS       c00020_gnlPro..        16240 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBDMOJGJ_20.
ACCESSION   c00020_gnlPro..
VERSION     c00020_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 12:00:03
            Original ID  :: gnl|Prokka|IBDMOJGJ_20
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 8516
            Orig. end    :: 24756
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16240
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[18516:21328]"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..12812
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="2000"
                     /detection_rule="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /neighbourhood="10000"
                     /product="Pyruvate2acetate-formate"
                     /protocluster_number="1"
     cand_cluster    1..16240
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((PFL_acetate1 or PFL_acetate2) and
                     Radical_SAM)"
                     /kind="single"
                     /product="Pyruvate2acetate-formate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16240
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Pyruvate2acetate-formate"
                     /region_number="1"
                     /rules="((PFL_acetate1 or PFL_acetate2) and Radical_SAM)"
                     /tool="gutsmash"
     CDS             complement(83..709)
                     /locus_tag="ctg20_12"
                     /transl_table=11
                     /translation="MVLVMSRFGIDLGFGEKNIGDVCRQNEVDSCTFLTVVNFLTEETP
                     AVINGIDNCLSVGSLITYLHNAHDYFLNFRLPHIRRKLTEAIIGCPGDIAFAITKFFDD
                     YVYEVHKHMSYEEKIVFPYVRNLQDGVKDSKYNISIFRKRHDQIEMKIVELKNILLKYY
                     PGPDNYLLNSVLFDIFATEQDLASHNRVEDYLFVPAVLAIEKTIK"
     CDS             complement(801..1952)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Ribonuc_L-PSP"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1038:Endoribonuclease L-PSP (Score: 49.1; E-value:
                     1.7e-15)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg20_13"
                     /sec_met_domain="Ribonuc_L-PSP (E-value: 6.9e-16, bitscore:
                     49.1, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTFTTKTYEQNTIYAQICSFESKGGVTEYHIMFSVTDPSLSFGEQ
                     LDSLQRAYDAVTKKEAGNAVAVFRRYFLSDAANQADILMERECENPFCALSIVQQAPLN
                     GTKIALWTWLQTGMATETCNSGMFEASHNGYRHLWNGGAHNKAATSEYQTRLLLNDYVM
                     QLTEQHCTLAADCIRTWFFVQNVDVNYAGVVKARKDVFITQNLTEKTHYISSTGIEGRH
                     ADPDVLVQMDAYTVDGLQPEQIQFLYAPTHLNPTYEYGVTFERGTAVSYGDRKHIFLSG
                     TASIDNKGEIVYPGDILKQTGRMMENISALLEEAGASIGDIMQAIVYLRDPADYENVQK
                     YISTHYPELPHLIVLAPVCRPGWLIETECVAIIPADLPQYPCL"
     CDS             complement(1963..2676)
                     /locus_tag="ctg20_14"
                     /transl_table=11
                     /translation="MNRMFFSFIINALLFSCFFVSCDDGKIYDEGKHVEIEGGIARVTA
                     TIQGVQTWPSDYTIVVAGFKKDDEYAAVAKTVTTADDGSMDLILKGISNEVSQIEVCVI
                     NKLRKRIVSFYQTDFTDSSDTLKLDIGTVNASLFNGIQKSIFDASCTGCHGAGASAADG
                     LYLTEGKSYSALVNVKANSSNEGKILVKPGDADNSFIMDVLTVGASNHYHNDLLSGSPE
                     KISLLKNWIEGGAQE"
     CDS             complement(2688..3902)
                     /locus_tag="ctg20_15"
                     /transl_table=11
                     /translation="MKQLITTIIALLFLPLTVLAQHEEDTENGVVSLSGKEGFTIGTKK
                     GDFVFKPYMLVQTSANISYYDDEGLDLAYNQDNIANSGFSIPYAILGFTGKAFNMVTFN
                     LSINAASSGGGILQQAWFDVKLKESFAIRVGKFKTPFAHAYLTTLGETLMPTLPVSLTA
                     PVILPYSLNAVTPNIGTGFDLGVEVHGLIKEKFGYEVGIFNGTGSSVNVASKTFSDDWH
                     IPSLLYAGRITYMPKGVMPSNQGNPNRLKEDKILFGLSTSLNVESENESTNDYRAGAEF
                     AMLKNRLYLGAELYYMNVGFTKRQKIDESYNYLGGYVQGGYFVTNRLQATARYDFFNRN
                     GVDTNGFLNMPAVGFNYFFTGCNLKLQAMYQFIGRTGHDTQLDRDNDDLGLAMHSGTVL
                     LQYTF"
     CDS             complement(3920..4975)
                     /locus_tag="ctg20_16"
                     /transl_table=11
                     /translation="MLVYIAKRNGAQFKNYGRVLHDQAIYGVKPEGKLSVQYTYETFSF
                     PDGETYELCKPEYSISEWYADSIAPKDLFCTVRIPLRHVGMGQMMALDPTEIEALAAKS
                     NYPEYGISGRCNYISERGVMRLGLSGNKAQHADLTIELGFSSDMGVTNSRYPEEICEGQ
                     IQMDQGSMMGLSYDQLDVSTEEMENVDLYLHALGVPARRNVNDSQVIKGEQKFYEAKCH
                     LCHVTTLHTKTRGAALLNGTQLPWLGGQTIHPYSDFLLHDMGSEIMGVGLNDNYVSGLA
                     RGNEWRTTPLWGIGLQETVNGHTYYLHDGRARNLVEAIMWHGGEGEASKNLFKKMSKED
                     RDALITFINSL"
     CDS             complement(5492..6679)
                     /locus_tag="ctg20_17"
                     /transl_table=11
                     /translation="MKKNFLSFATLMLGIALTFSACSDDDNNGPDTETPADLDYSAENA
                     DAWGNYMYNVASLLKNDAANLYKYWNEDYKGAGPYAEAFKKHNIGGETSIKTALNGIEQ
                     IFDKCAEIANEVGSAKIGDPLDKYNSGDKEGALYAVESWYSWHSRDDYTNNIWSIRNSY
                     YGTVSSNATNDQNDIQTSSIYKLVEAMDADMNKQLDDAIHAAADAIQNIPQPFRNNINS
                     DEALAAQDACLSLENTLKEVKAAVRAAYENTPNDSKLEAILVQYTDYVVLPTYKSLMEK
                     NAALFEAAKQFKNSPSNSNFDAASEAWLVAREPWEKSEGFLFGPVDTENLDPNMDSWPL
                     DQNIIVSILKSGNFDKIEWDEDDDSADIEAAQNVRGYHTLEYLLFKDGKPRKVNN"
     CDS             complement(6717..8024)
                     /locus_tag="ctg20_18"
                     /transl_table=11
                     /translation="LAITLLGSCATAFAQSNDEPTAAEKSAETYAGGYDKFRFGGYGEI
                     LANFMDYGINRFYGGNNGNAKTNRNSISIPRFVVAFDYKFNPKWILGAEIEFEAGGTGT
                     AYELENTENGEYETEVEKGGEVALEQFHITRLIHPAFNVRVGHIIVPVGLTNAHHEPIN
                     FFGTSRPEGEATLIPSTWHENGIEVFGTFGRDYTRFSYEALVVAGLNACGFSRDEWVAG
                     GKQGIFETDNFTSPAYVGRLNYEGVPGLRLGASFYYCNNVGANSDKPHTFVSIGKSPLR
                     ICTADLQYKNKYVTARGNMIYGSLSNAEALSGKIGSQSNTSPYSRLTPVAKNAVSYAGE
                     VGVNLRSIFKDNKKVPVIYPFARYEYYNPQEKGEGRQTMDPRTKVSMWTAGLNWYALPN
                     LVVKADYSTRKIGGGKYNSENEFSLAVAYVGWFLSK"
     CDS             8429..9058
                     /locus_tag="ctg20_19"
                     /transl_table=11
                     /translation="MITQYDLYETPSPKGEDGKKSLHARVCPKKTYTSQEFVEHVAAFE
                     HLPKNQIGGALAAIVDDLCYLLADGNIVELGDLGFFSTSLKCLKDTDDDEDEIKPKSIA
                     FQNVHLRISSEFRKRIKHEMKFQRVHSLTRRPKIVNSTVKERMKKMVSFLKINICITRK
                     EYIGLVGLTPYEAMNELNDFISQGLLRRRGAGRSVVYVAGENLKVE"
     CDS             9579..9725
                     /locus_tag="ctg20_20"
                     /transl_table=11
                     /translation="LVVSGIKKGLSCEGWFLFYFFDIIYNPSCLIPISGDTLHYIYRFS
                     NYL"
     CDS             10001..12073
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: PFL_acetate2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Gly_radical"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_21"
                     /sec_met_domain="Gly_radical (E-value: 6e-45, bitscore:
                     143.0, seeds: 99, tool: rule-based-clusters)"
                     /sec_met_domain="PFL_acetate2 (E-value: 3.4e-266, bitscore:
                     875.0, seeds: 33, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFKVEREKGVYDAETKYPQGIDTYGPGYIDKENEVIVGLQTDAPL
                     KRGIYPKCGTRMVENSLEAYGYKLDPMTKEIFTKYRKTHNEGVFSAYTDEMLAARRSAI
                     ITGLPDAYGRGRIIGDYRRVALYGTEILIAEKKHYLKRLDIQELTEEIIQSREEISEQI
                     KALKAFEKMCAGYGFDVTKPAKDAREAVQFVYLGYLAAVKDQDGAAMSLGRTSTFLDIY
                     IEKDIREGKLTEEEAQELIDQFIIKLRIVRFLRTPEYNDLFSGDPVWVTESLGGQGVDG
                     RSLVTKTSYRYLHTLYNLGPAPEPNLTVLWFNNAPENWKRFCAKVSIDTSAIQYENDDL
                     MRPDYGDDYGIACCVSPMKIGKQMQYFGARANLAKCLLYAINGGRDERSGVQVAPRFEP
                     ITSEYLDYNEVMEKYEQMMRWLAKVYVNALKIIHYMHDKYAYEAFEMALHDGSVERIRA
                     TGIAGLSIVADSLAAIRDTKVKVIRDERGLAVGFEREGDYVPFGNNDDRTDSIAVDITE
                     KFMEYLRQHQTYRNATPTQSILTITSNVVYGKKTGATPDGREGGTPFAPGANPMNGRDT
                     KGAVAALASVAKLPFQHAHDGISYTFAVSPATLGKERDIQIANMVGLLDGYFTPDGGQH
                     LNVNVFDKELLLDAMEHPENYPQLTIRVSGYAVNFVKLTREQQLDVISRTINHSL"
     CDS             12081..12812
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Pyruvate2acetate-formate: Radical_SAM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1015:4Fe-4S single cluster domain (Score: 72.3;
                     E-value: 1.6e-22)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg20_22"
                     /sec_met_domain="Radical_SAM (E-value: 2.3e-36, bitscore:
                     116.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LEIKGNIHSLESFGTVDGPGIRFVVFMQGCPLRCLYCHNPDTWDS
                     KGLAKYQMTPEELLAEVLRYKNFIAKGGVTVTGGEPLLQAEFLREFFRLCREAGIHTAL
                     DTSGYICTPKALAVLEYADLVLLDIKTIDPDLHPRLTAVKLDNTLRFLDELEKRGVPVW
                     IRHVIVPGLTDNDEALDKLAEYISHYTVVQKAELLPYHTMGAYKYEAQGLDYKLKEVEP
                     LSAERLANAKEIFKKHGITIW"
     CDS             12859..13800
                     /locus_tag="ctg20_23"
                     /transl_table=11
                     /translation="LSHIVTQIKVGMNMEQHHHDHHHHEITSLNKAFIIGISLNLAFVV
                     AEFTAGFWYNSLGLLSDAGHNLGDVASLVLAMLAFRLAKVHPTCSYTYGYKKSTVLVSL
                     LNAVILLVAVGIIIAESIGKLLHPRPVEGDAIAWVAGIGVVINALTAWLFMKDKDKDLN
                     VKGAYLHMAADALVSVGVVVSGIVIAHTGWYIIDPIIGLLIAIVIIVSTWGLLRDSIRL
                     SLDGVPAGTDIDKVEKTIHSVEGVEGVHHLHIWAISTTETALTAHVSVADISEMERIKQ
                     EIKHDLQHVGIQHATLEFETSGFKCDGHCCSD"
     CDS             13961..14527
                     /locus_tag="ctg20_24"
                     /transl_table=11
                     /translation="MEPIINSQAPEFKVQAYHNGSFKTVSSDDIKGKWAIFFFYPADFT
                     FVCPTELVDMADKYDQFQAMGVEVYSVSTDSHFVHKAWHDASETIRKIKYPMLADPTGV
                     LSRAFGVMIEEDGMAYRGTFLVNPEGKIKLAEINDNGIGRNADELLRKVEAAQFIAEHP
                     SEVCPAKWKKGGETLKPSIDLVGKI"
     CDS             14732..16171
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pyr_redox_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg20_25"
                     /sec_met_domain="Pyr_redox_2 (E-value: 3.3e-47, bitscore:
                     151.8, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LELLNDVASCSDKITVQVADGEGLEFSLLKNGEKTGIKFRGVPNG
                     HEFTSLLLAILNSDGKGKNIPDESICNRVKALNGPVKLTTYVSLTCTNCPDVVQALNAM
                     ATLNPEISHEMVDGAINQEEVAAMKVQGVPSVFADGKLIHVGRGDFGELLGKLEAQYGV
                     KEENLSVVEKNYDVIIVGGGPAGSAAAIYTARKGLAVAVVADRIGGQVKETVGIENMIS
                     VSQTTGQQLALDLMSHMKDYPIDILEHRRIEKVEVEGREKLLTTSTGEKLIAPAVIVAT
                     GASWRRLNVPGESEYIGRGVAFCPHCDGPFYKGKHVAVVGGGNSGVEAAIDLAGICSKV
                     TLLEFADELKADQVLQDKARSLPNVEIFMHSQTMEVLGNGEKVTGIRIKDRKTEEVRNI
                     ELDGIFVQIGLAANSGPFREVVDTNRQGEIVIDSHCRTSVPGIYAAGDVSTVPYKQIII
                     SMGEGAKAALTAFEDRMRGML"
ORIGIN
        1 cagtaaagta accagtccgc aacggataat ggcagacggt tcggcaatag ctattttgat
       61 gttagggttc ataaagcagc agtcatttta ttgttttttc aattgccagt acagcgggaa
      121 cgaagaggta atcttctacc cggttatgag aagccaaatc ctgttcggtg gcaaagatgt
      181 cgaacaggac actgttcagc aggtaattgt caggcccggg atagtatttg agcaggatat
      241 ttttaagctc tacgattttc atctctatct ggtcgtgccg tttgcggaaa atactgatat
      301 tgtatttgga gtccttcacg ccgtcctgta gattgcggac ataaggaaag acaatctttt
      361 cttcgtacga catgtgctta tgtacttcat aaacataatc gtcgaagaat ttggtgatgg
      421 cgaaggcaat atcacccggg cagccgataa tcgcttccgt cagtttgcgg cggatatgcg
      481 ggaggcgaaa gttcaggaaa taatcgtgcg cattgtgcag ataggtaatc agtgaaccga
      541 cagagaggca gttgtcgata ccgtttatca cggcgggagt ctcttccgtc aggaaattga
      601 caacggtcag gaaggtacag ctgtccactt cgttctgccg gcatacgtcg ccgatatttt
      661 tctctccgaa tcccaggtcg atgccgaagc ggctcataac gagaaccatc gggtagttct
      721 cgcaaatcag gtcgctcatt ttatctgtct ctgtgtattt tccttgttta tacatagttg
      781 ttatttttag gatgttatgt ttatagacag gggtattgcg gaaggtcggc tggtataata
      841 gccacgcatt ccgtttcaat cagccatccc ggacggcata ccggtgccag tacgataagg
      901 tgcggcaatt ccggataatg ggtactgata tatttctgta cattctcata gtctgccggg
      961 tcgcgcaggt aaacgatggc ctgcatgatg tcgccgatgg aagccccggc ctcttccagt
     1021 agggcgctga tgttttccat catccgcccg gtttgtttca atatgtcgcc gggatagaca
     1081 atctcgcctt tattgtcgat actggctgtg ccggacagga agatatgttt acggtcgccg
     1141 taggagacgg cggtaccccg ttcaaaagtg acgccatatt cataggtcgg attgagatgg
     1201 gtgggagcat acaggaactg tatctgttcc ggttgcaggc cgtcgacggt ataggcatcc
     1261 atttgtacca atacatccgg atcggcatgg cgtccttcta taccggtgct ggatatataa
     1321 tgtgtctttt ccgtcaggtt ctgcgtgatg aaaacgtcct tgcgggcttt tactacgccg
     1381 gcataattga cgtctacatt ctgtacgaag aaccaggtcc ggatacaatc ggcagccagg
     1441 gtacaatgtt gttcggtcag ttgcatcaca tagtcgttga gcagcaaccg ggtctggtat
     1501 tcggaagtcg ctgccttgtt gtgtgcacct ccgttccata ggtggcgata cccgttgtgg
     1561 gatgcttcaa acattcctga gttgcaggtt tctgtcgcca tcccggtttg cagccaggtc
     1621 cataaggcta tttttgtgcc gttgaggggt gcctgttgca cgatggataa ggcgcagaac
     1681 gggttttcac attcccgttc catcaatata tccgcctggt tggccgcatc gctcagaaag
     1741 tagcgacgga aaacggctac ggcattacca gcctcttttt tagtcactgc gtcgtatgct
     1801 ctttgtaaag aatccaactg ttccccgaaa gaaagtgaag ggtcggtaac ggaaaacata
     1861 atatgatatt ccgttacccc tcccttgctt tcaaaagaac aaatttgagc gtatatggtg
     1921 ttttgttcgt atgtttttgt tgtgaatgtc ataattataa attcattctt gggctccccc
     1981 ttcgatccaa ttcttcaaaa gagaaatctt ttcgggtgaa ccggataaca aatcattatg
     2041 ataatggttg ctcgccccta ctgtcagtac atccatgatg aagctgttat ccgcatcccc
     2101 aggctttaca agtattttcc cttcattcga agagttcgct tttacattga ccaaagcact
     2161 gtaacttttt ccttcagtca gatatagacc atctgcagca ctggccccgg ccccatgaca
     2221 gccggtacag ctagcatcaa aaatgctttt ttgtatgcca ttgaataaac tcgcgttgac
     2281 cgtacctata tccagcttta gcgtatcgga tgaatccgta aaatccgttt gatagaaact
     2341 gacaatacgt tttctcagtt tattgataac acaaacttct atctggctga cctcatttga
     2401 aatacctttt aaaataaggt ccatcgaacc atcgtctgcg gttgtcactg ttttggcaac
     2461 cgcagcatat tcatcatcct ttttaaatcc ggcgacaaca atcgtataat cgctgggcca
     2521 ggtttgaacg ccctggatag ttgctgtaac cctggctatg cctccctcta tctctacgtg
     2581 tttgccctcg tcgtaaattt tgccgtcatc gcaggaaacg aaaaaacaag agaatagtag
     2641 cgcatttatt atgaatgaaa aaaacattct attcatggtg tgacaattta gaatgtatat
     2701 tgaagcaaaa ctgttcctga atgcatagct aaccctagat catcgttatc acgatcaagc
     2761 tgtgtgtcat gtcccgtacg tccgatgaac tgatacattg cctgtaattt cagattacat
     2821 ccagtaaaga aatagttgaa tccgactgcg ggcatattca ggaaaccgtt tgtgtctact
     2881 ccgttgcggt taaagaaatc gtagcgggcc gtcgcttgca ggcgattggt tacaaaataa
     2941 ccgccttgta catatccgcc cagatagtta taactttcat ctattttctg tcgtttggtg
     3001 aaaccaacgt tcatataata gagctccgct cccagataaa gacggttttt caacatggca
     3061 aattctgcac cggcacggta atcgtttgta ctttcatttt cgctttctac atttaaagac
     3121 gttgataggc cgaataatat tttatcttct ttcagacgat tgggatttcc ttgattagac
     3181 ggcataacac cttttggcat gtaagtaata cgtccggcat ataataaaga agggatatgc
     3241 caatcatcac tgaatgtttt tgaagccacg tttacggagc tacctgtacc attaaatata
     3301 cctacttcat agccgaattt ttctttgatt aatccgtgga cttctacacc caggtcaaag
     3361 cctgtgccga tattgggagt tacggcattc agtgaatatg gcagaatgac aggtgctgtc
     3421 agtgaaacag gaagagtagg catcagtgtc tctcctaatg ttgtcaggta agcatgtgcg
     3481 aacggtgttt tgaacttacc tacgcgtatg gcaaagcttt ctttgagttt tacgtcaaac
     3541 caagcctgtt gcagaatacc acctccgctt gaggctgcat tgatagacag gttgaatgta
     3601 accatattga acgcttttcc tgtaaaaccg agaatggcgt atggaatgga aaaaccggaa
     3661 tttgcaatat tgtcttgatt gtaagcaaga tccaaacctt catcatcgta ataactgata
     3721 tttgcactgg tttgaacgag catataaggt ttaaaaacaa aatcgccttt tttagtgccg
     3781 atagtgaagc cttctttgcc ggacaaagat accaccccgt tttccgtatc ttcttcgtgc
     3841 tgggccagta ctgttaatgg taagaacagt aatgcaatga ttgtagttat tagttgtttc
     3901 atctttgttg ttttgctaat tataatgaat tgataaatgt gattaacgca tcgcgatctt
     3961 ctttactcat tttcttgaat aaattcttgg atgcttctcc ttcacctccg tgccacatga
     4021 tggcttctac cagattgcgt gcacgtccgt catgcagata gtaggtatgt ccgttgactg
     4081 tctcttgaag gccgattccc cataaaggag tggtacgcca ttcattgcca cgtgccagac
     4141 cactgacata gttgtcgttc agtccaactc ccataatctc agatcccatg tcatgcaaca
     4201 gaaagtcgga atacggatgg atggtttgtc ctcccagcca gggtaattgt gtcccattca
     4261 gtaaagcagc accacgtgtc ttggtgtgca gagtcgttac gtggcataaa tgacatttgg
     4321 cttcatagaa tttttgttct cctttaatca cctgcgaatc attaacgttt cttcgggccg
     4381 gaacacccag ggcatgcagg taaaggtcta cattttccat ctcttctgtc gagacatcca
     4441 gctgatcata cgaaaggccc atcatgcttc cctgatccat ttgtatctgt ccttcgcaga
     4501 tctcttccgg ataacgactg tttgttacac ccatatcgct ggagaaaccc aattcgatag
     4561 tcaagtctgc gtgttgcgct ttattaccgg ataatcccag tcgcatgaca cctcgttcgg
     4621 aaatgtagtt gcaacggccg ctaatgccat attcaggata attacttttg gcggcaagcg
     4681 cttcgatctc cgtcgggtcg agtgccatca tctgccccat gccgacatgg cgtaaaggaa
     4741 tacgtacggt acagaacaga tcctttggag cgatactgtc ggcataccat tctgaaatcg
     4801 aatattcagg tttacataat tcgtatgttt cgccatcggg aaacgagaaa gtttcgtaag
     4861 tatattgaac ggaaagtttt ccttccggct ttacgccata tatggcctgg tcgtgcaata
     4921 cacggccgta gtttttgaat tgtgccccgt ttcttttggc gatataaacc agcatggaag
     4981 aaaatccgta gcttccggag cctccttcgc tccataatgt cggtttggtt cgtccggcat
     5041 tgcgatggca gcttccgcag gaataacccg catacaccgg accgaggccg ccacctgtgc
     5101 cgttactact agtacgtacg tcgtcataca atctatctcc attgttaaac cgggtcgaat
     5161 atttaccgga aacccagtct gcttctgtgt cgtacgctac ggatgaattg aggaagatag
     5221 tcgaagtccc ggcagagagc gcataattat taggaacttc tacatcatcc atatctattc
     5281 cttctttgtc gcaggaacag agtggcacga ggaacaacag aggaaaaaac agatgtcgaa
     5341 atttcatatt gatttttctt tatttttgat cagatcttat tgttttgaaa tccatcgtca
     5401 aacattccaa agccttggag caaccaggtc gcataaccgg gctacttcaa ggcattatag
     5461 taatggtgaa aaagattcac ctggttattt tttagttgtt tactttacgc ggtttgccgt
     5521 ctttgaacaa caggtattcc agcgtgtgat aaccacgtac attctgtgcg gcttctatat
     5581 cagcgctgtc atcgtcttca tcccattcga ttttgtcgaa gtttccggat ttcaggatac
     5641 ttacaattat gttctggtcc aaaggccagc tgtccatatt cgggtcaaga ttttctgtgt
     5701 caaccggacc aaacaggaat ccttcgctct tttcccacgg ttcgcgggcc acaagccatg
     5761 cttcgctggc agcatcgaaa ttactgttgc taggactgtt tttgaactgt ttagcagctt
     5821 cgaacagggc ggcatttttt tccatcaatg atttgtaggt aggcaataca acatagtcgg
     5881 tatattgaac caggatggct tccagtttgc tgtcgttcgg tgtgttttca taggcggcac
     5941 gtacggctgc ttttacctct ttcagcgtgt tttccaatga aagacaagca tcttgagcgg
     6001 ctaatgcctc atcgctgttg atgttgttac ggaaaggctg tgggatattt tggatagcgt
     6061 cggcggctgc atggatagca tcgtccaatt gcttgttcat atcggcatcc attgcttcaa
     6121 ccaatttgta gatggagctt gtctgaatgt cgttctggtc gttggtggcg ttgcttgaaa
     6181 ctgttccgta gtaagagtta cggattgacc agatgttgtt ggtatagtcg tcgcgtgagt
     6241 gccagctata ccacgattct acggcataaa gtgcaccttc tttgtcacct gaattgtatt
     6301 tgtcgagcgg gtcaccgatt ttggcactac ctacttcgtt ggcgatttcg gcacatttgt
     6361 cgaagatttg ttcgataccg ttcagtgccg tcttgatgct tgtttcgcct ccgatgttat
     6421 gtttcttgaa agcttcagca taagggcctg cacctttgta gtcttcattc caatatttgt
     6481 atagattggc agcatcgttt ttcagcaagc tggcaacgtt atacatgtaa tttccccatg
     6541 cgtctgcatt ctctgcagaa tagtcaaggt ctgccggagt ttctgtatcc ggtccgttgt
     6601 tgtcgtcgtc agaacaagca ctgaaagtca atgctatccc taacataagt gttgcaaatg
     6661 ataaaaaatt ctttttcatt ttcttttgtt attaaatagg tttatattct ttcttcttat
     6721 ttactcagaa accagcctac gtaggcaacg gccaggctga actcgttttc actgttgtat
     6781 tttcctccgc cgattttgcg tgttgaataa tctgctttga caaccaggtt aggaagtgca
     6841 taccagttta aaccggccgt ccacatgctg actttggtgc gcgggtccat ggtctgtctg
     6901 ccttcaccct tttcttgcgg attgtaatat tcgtaacgcg cgaacggata aataaccgga
     6961 actttcttat tgtctttgaa gatagagcga aggttaacgc ctacttcgcc ggcatagctg
     7021 actgcatttt tagcaaccgg ggtaagacgg ctgtaaggag atgtattact ttgtgatcca
     7081 attttaccgg agagtgcttc ggcattgctt aagcttccgt aaatcatatt tccccgggct
     7141 gttacatact tgtttttgta ctgaagatct gccgtacaaa tacgtagcgg acttttccca
     7201 atactgacaa atgtgtgcgg tttgtcggag ttcgcaccca cgttgttaca ataatagaag
     7261 gaagcgccta gtcttaatcc gggaacacct tcatagttta aacggcctac gtaggcggga
     7321 gaagtgaaat tgtccgtctc gaaaatgccc tgtttgcctc ctgcaaccca ttcgtcgcgg
     7381 gaaaatccac aggcatttaa tccggcaaca accaacgctt cataactgaa gcgagtataa
     7441 tccctaccaa acgtaccgaa cacttcgata ccgttttcgt gccatgtgga ggggataaga
     7501 gttgcttctc cttcagggcg ggatgtaccg aagaagttga taggttcatg atgcgcgttc
     7561 gttaaaccga ccggaacgat aatgtgtccc acccgaacat tgaatgcggg atggattaac
     7621 cgtgtgatat gaaactgttc cagtgcaact tcgccacctt tttcgacttc agtttcgtat
     7681 tctccgtttt ctgtattttc aagttcatag gcagtacctg taccacccgc ttcgaattca
     7741 atttctgctc ctaatatcca tttaggatta aatttatagt cgaaagctac aacgaaacga
     7801 gggatggaga ttgagtttct gtttgttttt gcatttccat tattcccccc gtaaaagcgg
     7861 ttgataccat aatccataaa attcgcaagg atttcaccat acccgccaaa tctgaattta
     7921 tcataacccc cggcataagt ctctgccgat ttctcagccg cagttggctc gtcattgctc
     7981 tgcgcgaagg ctgttgcgca ggatccaagt agagtgatag ccaacaaatt tgttaatttt
     8041 ctcattgcct tttgtaattt ttggcaaaat tagggcggtt aaaaagtctg cgcaatcgcg
     8101 tatagtaggt aaaaaatggg tgatcttacc tatttgtagg tatttgtggg tgtctgaatg
     8161 gatatttgtt atctgattct tgttcgtagg taataatatg tataaaataa aaccagtcag
     8221 ggagttccct tcgtttaaaa taaaaaatcg ttcgacaatc attcttcatg catttaacag
     8281 ctatcgaata atcattcgac aattgtcgaa cgaataaaga atgattgtcg aatgattttt
     8341 tttctagaag cgaaatttat ttttagaagt atttcgattt atcagggaga aacaagttat
     8401 atttgaacaa ttaatatcaa tataacctat gatcacacaa tacgacctgt atgaaacacc
     8461 ttcacccaaa ggggaagacg gtaaaaaatc gctgcatgcc cgtgtttgtc cgaaaaagac
     8521 ttacaccagt caagagtttg tagaacatgt ggcagccttt gaacatctgc cgaagaatca
     8581 gattggcggg gcacttgctg ccattgtcga cgatctttgt tatctgcttg ccgatggaaa
     8641 cattgtggaa ttaggtgatc ttggattttt ttctacttca ttgaagtgcc tgaaggatac
     8701 ggatgacgat gaggatgaaa tcaaaccgaa atcgatcgct tttcaaaatg tacatctgag
     8761 aatcagcagt gaattccgaa aaagaatcaa acatgagatg aagtttcaac gcgtgcattc
     8821 ccttacgcgg agaccaaaaa ttgtcaattc taccgtgaaa gagcggatga aaaaaatggt
     8881 ctctttcctc aaaataaaca tttgtattac ccgaaaggaa tatataggac tggtcggatt
     8941 gacaccttac gaggcgatga atgaactgaa cgattttatc agccaggggc ttcttcgccg
     9001 tcgcggggcg ggcaggtctg tggtatatgt tgcgggggaa aatctgaagg tagaataatt
     9061 atataggtaa tattttccct gtaatcccta tttatggtta gaaatgagct cgttttacat
     9121 atatataggt attgcctgtg cctttccgtg gttttacctt tgccgtatca attaagtttt
     9181 actattagta taaatcgtcc tgaccaaaat ccgatttgtt gatttttatg tacacctatt
     9241 atttaaggta aatacccatg gaagggagtt tttttattgg ttgtcccttt catatataaa
     9301 agggagccat cctgtgaaga atggctcttt tttatttatc aaagaaagca atttttgcaa
     9361 atattgttta ttccaatgat caattttccc gattataaca cagaataggt agtaggaagc
     9421 tcttttttta ctatataata ggtattgtgt actccccttg acggctctat ctttgcaaca
     9481 tagaaaaaag taacactatt agtataatcg ctatatcaaa accttttgct aattatgtaa
     9541 gcatataaga tgattaaacg tgtgtcggaa attttttatt ggttgtttcc ggcataaaaa
     9601 agggactctc ctgcgaagga tggttccttt tttatttttt tgatattatt tataatcctt
     9661 cctgtttgat acctatatca ggcgatacgc tgcactatat ctaccgtttt agtaactatt
     9721 tgtagggatt ttggccgttg ggaatacatg atgtttttgt tgattgtttc gcatgccata
     9781 taaataacgt acctttgcac cgaaattaaa accgaagaaa acaaaataag gtatgaagtt
     9841 tgaaaacgag aactgggcgc agttcaaagg cgaaatttgg aaaagagaga ttaacgtaag
     9901 ggattttatc cagaacaact acaaacctta cgaaggggac gactctttct tgaaagactc
     9961 ctcagataag acgaagaaag tttgggataa attgaccgaa atgtttaagg ttgaaaggga
    10021 gaagggtgtt tacgacgctg aaacaaaata tcctcaaggt atagatactt acggaccagg
    10081 ttatattgac aaagaaaacg aagtaattgt cggcctgcaa accgatgccc ccctgaaacg
    10141 cggtatttac ccgaaatgtg gtacccgcat ggtggaaaac agtctggaag catatggcta
    10201 caaactggac ccgatgacaa aagaaatctt cacgaaatac agaaagacgc ataacgaagg
    10261 cgtattctcc gcttatacag atgaaatgct tgcagcgcgc cgttccgcta tcatcaccgg
    10321 cctgccggat gcttacggac gcggacgtat tatcggtgac taccgccgtg tagcacttta
    10381 cggtacggaa atcctgatcg ctgaaaagaa acattatctg aaaagactcg atattcagga
    10441 actgaccgaa gagatcatcc agagccgtga ggaaatatcc gaacagatca aggcgctgaa
    10501 ggctttcgaa aagatgtgtg ccggttatgg tttcgacgtg accaagcctg caaaggatgc
    10561 acgcgaagcg gttcagtttg tctatctggg ttatctggct gcggtgaagg accaggatgg
    10621 ggctgccatg tcgttgggac gtacttctac tttcctcgat atttatattg aaaaagatat
    10681 ccgcgaaggc aagctgacgg aagaagaagc tcaggagctg atcgaccagt ttattatcaa
    10741 actgcgtatc gtccgtttcc ttcgtactcc ggaatataac gacctgttct ccggtgaccc
    10801 tgtttgggta accgagtctt tgggcggaca gggtgtcgac ggccgttcat tggtgacgaa
    10861 gacatcttac cgttatctgc atacattata taacctcggc ccggcaccgg aacccaactt
    10921 aacggtactg tggttcaaca acgctcctga aaactggaaa cgtttctgtg cgaaggtttc
    10981 tatcgatact tccgctatcc agtatgagaa cgacgatctg atgcgtccgg attatggaga
    11041 tgattatggt attgcctgct gcgtgtctcc gatgaagatc ggtaagcaga tgcagtattt
    11101 cggcgcacgt gccaacctgg ctaaatgttt gctgtatgcc atcaacggcg ggcgcgatga
    11161 aagatcaggt gtacaggtgg ctccgaggtt tgaaccgatc accagcgaat acctggatta
    11221 caacgaagtg atggagaaat acgaacagat gatgcgctgg ctggctaaag tttatgtgaa
    11281 cgcactgaag atcatccatt acatgcacga taaatatgcg tatgaagcat tcgagatggc
    11341 tttgcatgac ggttcggtag aacgtatccg cgcaacaggt attgccggcc tttctatcgt
    11401 tgccgactca ttggctgcta tccgcgatac gaaagtaaaa gtgatccgcg acgaacgtgg
    11461 cctggctgtc ggtttcgaac gtgaaggcga ttatgttcct ttcggtaaca atgacgatcg
    11521 tacagatagt attgctgtcg acatcactga aaagttcatg gaatatctgc gtcagcacca
    11581 gacataccgt aatgcaactc cgacacagtc tatcctgact attacgtcta atgtcgtata
    11641 cggaaagaag acaggtgcaa ctcccgacgg tcgcgaaggt ggtacgccgt ttgctccggg
    11701 tgcgaacccg atgaacggac gtgataccaa aggcgctgtt gctgcactgg cttctgttgc
    11761 taaactgccg ttccagcatg cacacgacgg tatctcttat acattcgctg tttctcctgc
    11821 aacgttagga aaagaacgtg atattcagat cgccaatatg gtcggcctgc tggacggtta
    11881 ctttactcct gacggcggac agcatctgaa tgtgaacgta ttcgacaagg agctgttgct
    11941 cgatgctatg gagcatccgg aaaactatcc gcagttgaca atccgtgtat cgggttatgc
    12001 agtaaacttt gtgaaactga cacgcgaaca gcagctggat gtgatttcaa gaacaatcaa
    12061 tcattctttg taattgaaag ttggaaatta aaggaaacat acattcacta gagagtttcg
    12121 ggaccgttga tggtcccgga attcgttttg ttgtctttat gcaggggtgt ccgctccgtt
    12181 gcctgtattg ccacaatccg gatacctggg atagcaaagg gcttgccaaa tatcagatga
    12241 cgcctgaaga attattggct gaggttttac gatataagaa ctttatcgcc aagggtggcg
    12301 tgactgtcac cgggggagaa cccttattgc aagctgaatt tctcagggag tttttccgtc
    12361 tttgccggga agccggtatt catacggcgc tcgatacatc cggctatatc tgcacaccga
    12421 aagccctggc ggttctggaa tatgccgacc tggtcttatt ggatataaaa accatcgatc
    12481 ccgacctgca tccccgtcta acggccgtga aactggataa tacgttacgt ttcctggacg
    12541 aactggaaaa acgcggtgtc ccggtttgga tacgccatgt cattgtgccc ggactgacgg
    12601 ataatgacga agccttggat aaactggccg aatacatcag ccactatacg gttgtacaga
    12661 aggcggaact cttgccttat cacacgatgg gcgcttataa atacgaggca caaggtctcg
    12721 actacaaact gaaagaggta gaacctttat cggccgaacg tctggcaaat gccaaagaaa
    12781 tatttaagaa gcacggtata accatctggt aatttaccta taatcaggta tatttttatt
    12841 gctctaaaaa acatagtttt gtcccatatt gttactcaaa taaaagtagg aatgaatatg
    12901 gaacaacatc atcacgatca tcaccaccac gaaataacct ctttgaacaa ggctttcatt
    12961 ataggtattt ccctgaacct ggcttttgtc gtagccgaat ttacggctgg cttctggtat
    13021 aattcattag gacttttgtc ggacgcaggg cataacctgg gagatgtagc cagcctggta
    13081 ctggctatgc tggctttccg gctggctaag gtgcacccga cttgcagcta tacctatgga
    13141 tataagaaaa gcactgtact cgtatccctt ctgaatgcgg tcatcctctt ggtggccgtc
    13201 gggattatta ttgctgaaag tataggaaaa ctgctgcatc cgcgtccggt cgagggtgat
    13261 gcgatcgctt gggtggcagg tatcggagtc gttataaatg cacttacggc atggcttttt
    13321 atgaaggata aggataaaga cttgaatgtg aaaggtgctt acttacatat ggctgccgat
    13381 gcactggtat cggtcggcgt ggttgtctcc ggaattgtta ttgcccatac cggatggtat
    13441 atcatcgacc cgattatcgg cctgttgatt gcgatcgtta tcattgtttc tacctgggga
    13501 ctgctgcgcg acagtatccg tctctctctg gacggtgtgc cggcgggaac ggacatcgat
    13561 aaggtggaaa agacgataca ttcggttgaa ggcgtcgaag gtgtccacca tcttcatatc
    13621 tgggcgatca gtacgaccga aacggcactt accgcccatg tttccgttgc ggatatttca
    13681 gaaatggaac gtatcaaaca ggagataaaa cacgaccttc agcatgtggg aatccagcat
    13741 gctacgctcg aatttgaaac gtcgggattc aagtgcgatg ggcactgttg ctcagactga
    13801 aacaggtata ttataaacct gatttactga tactcaaaga ttttgtctat gactgcataa
    13861 aacctttcga ttggattttt tgttcttacc tcgaatcggc aacttatctt tgcaccagta
    13921 acaaaaacaa aatagtaata acgattaaaa taaaaattct atggaaccta ttatcaattc
    13981 acaagcaccc gagtttaaag ttcaggcata ccacaacggt agtttcaaaa ctgtaagcag
    14041 cgacgacatc aaaggcaaat gggcgatttt ctttttctac ccggctgact ttacatttgt
    14101 ttgtccgacc gagttggtag atatggctga caaatatgac cagttccagg caatgggtgt
    14161 agaagtttat tctgtaagta cagattcaca cttcgtacac aaagcatggc acgatgcatc
    14221 tgaaacgatt cgtaagatca aatacccgat gttggcagac ccgacaggcg tattgagccg
    14281 tgcattcggt gtaatgatcg aagaagacgg tatggcttac cgcggtacat tcctggtaaa
    14341 tccggaagga aagatcaaac tggcagaaat caacgataac ggtatcggcc gtaacgccga
    14401 cgaactgctt cgtaaagtag aagctgccca gttcatcgcc gaacatccga gcgaagtttg
    14461 ccccgccaaa tggaaaaaag gtggcgaaac attgaaaccg agcatcgatc tggtcggtaa
    14521 gatctaatag taaaactgga ggccggcaac atattgtcgg ccttttttat ctaaacaaat
    14581 atcagttgtt ctattcataa ttaaaataaa ggattcaact atgttagatt catcaatgag
    14641 aaatcagttg tccggtatct ttagcggatt gacgaacgaa tatatatttg atatacaagt
    14701 ttctcctgaa catgaaagca ggaaggaact attggaattg ctgaacgatg tggcttcctg
    14761 ttccgataag atcaccgtac aggtggcaga cggcgaaggc ctggagttct ccctgctgaa
    14821 aaacggggaa aaaaccggta ttaaattccg gggcgttccc aacggacacg aatttacttc
    14881 gttgctgctg gctatcctga acagtgacgg caaaggcaaa aatattcccg acgaaagtat
    14941 ttgtaaccgt gtgaaggccc tgaatggccc ggtcaaactg actacatatg tttctttgac
    15001 ctgtaccaac tgtcctgacg ttgtacaggc tttgaatgcc atggctacac tgaacccgga
    15061 aatctctcac gaaatggtgg acggtgcgat caaccaggaa gaggttgctg ccatgaaagt
    15121 gcagggagta ccttccgtat ttgccgacgg taaactgatc catgtaggtc gtggagactt
    15181 tggcgaactg cttggcaaac tcgaagcgca gtatggcgtg aaagaggaga acctgtcggt
    15241 ggtagaaaag aactacgatg ttatcatcgt cggcggaggt cctgccggaa gtgcggcagc
    15301 tatctatact gcccgtaaag gtttggcggt ggctgttgtg gccgaccgta tcggcggaca
    15361 ggtgaaggaa actgtcggta tcgagaatat gatttctgtt tcgcagacga cggggcagca
    15421 gctggctctc gacctgatgt cgcatatgaa agattatccg atcgatatcc ttgaacaccg
    15481 ccgtatcgag aaggtggaag tcgaaggacg cgaaaagctg ctgacaacct ctaccggcga
    15541 aaaactgata gccccggccg ttatcgtagc aaccggagcc agctggcgta ggttgaatgt
    15601 ccccggagaa tccgaatata tcggacgcgg tgtcgctttc tgtccgcatt gcgacggtcc
    15661 gttctataaa ggcaagcatg tggctgttgt tggcggagga aattcaggcg ttgaggcggc
    15721 tatcgacctg gctggtatct gttcaaaagt gacgcttctc gaatttgccg atgagttgaa
    15781 agcggatcag gtcttgcagg ataaggcaag aagccttccg aacgtggaga tctttatgca
    15841 ttcccagacg atggaggtac tgggtaacgg tgaaaaagtg accggtatcc gtataaagga
    15901 ccgtaagaca gaagaagtcc gcaacatcga actggatggc atctttgtcc agatcggcct
    15961 ggcagccaac agcggtccgt tccgtgaggt ggtagatacg aaccgtcagg gtgagatcgt
    16021 gatcgatagc cattgtcgta caagcgttcc aggtatctat gcggccggcg acgtatcgac
    16081 tgtcccttat aagcagatca ttatttcgat gggcgaaggg gccaaagcag ccctgacagc
    16141 tttcgaagac cggatgcggg gaatgttata agccgcagaa ctttccggaa ggcataaaaa
    16201 taatacccgg gtataaatcg attcagaagc gtttctatgt
//
