LOCUS       c00049_gnlPro..        13416 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|LCJNNCJH_49.
ACCESSION   c00049_gnlPro..
VERSION     c00049_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 12:12:43
            Original ID  :: gnl|Prokka|LCJNNCJH_49
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13416
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..837)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) QRPTase_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_1"
                     /sec_met_domain="QRPTase_C (E-value: 2.5e-63, bitscore:
                     202.7, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="QRPTase_N (E-value: 6.2e-28, bitscore:
                     86.7, seeds: 125, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKLIDDLIKLAFAEDIGDGDHTTLCCIPETAMGKSQLIIKEDGV
                     LAGVEMAKRIFHDFDPELKMTVFIQDGAEVKKGDIAFVVEGKIQSLLQTERLMLNVMQR
                     MSGIATTTRKYAKALEGTKTHVLDTRKTTPGMRMIEKEAVRIGGGMNHRIGLFDMILLK
                     DNHVDFAGGIEQAITRAQNYLKEKGKSLKIEIEVRNFDELEQAMKVGGIDRIMLDNFNI
                     ENTKEAVRRINGRFEVESSGGITFDTLRDYAECGVDFISVGALTHSVKSLDMSFKAC"
     protocluster    1..13416
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[6330:12298]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      6331..12298
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13416
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13416
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(841..1212)
                     /locus_tag="ctg49_2"
                     /transl_table=11
                     /translation="MKRLLLTFALIFAFACAQAADITSISNAFKAGNASSLSGAMDKVV
                     DVALPGSSKKCNGSEAVSMLSSFFSSNKPSGFSVVHHADKKESGFLVGKLPTSSGEYRV
                     NITYRAEGNTAIIQSIRIE"
     CDS             1301..1774
                     /locus_tag="ctg49_3"
                     /transl_table=11
                     /translation="MKIGLIVIGKTDAGYFVEAINEYKNRLTHYIPFEMEVIPDIKNVK
                     NLSEAQQKEKEGELILKALQPGDYLVLLDEKGKEFTSMQFSTYLEKKMHTVPKRLVFVV
                     GGPYGFSEAVYKAASEKISLSKMTFSHQMIRLIFIEQIYRAMTILNNEPYHHE"
     CDS             complement(1881..2201)
                     /locus_tag="ctg49_4"
                     /transl_table=11
                     /translation="MAWILLIIAGLFEIGWPLGFKLASMHSKYFIWFIGLSILSMGLSG
                     YFLYLAQKSIPIGTAYVIWTGIGAIGTVLLGILFFHDSANIFRLLFLSLILIGIVGLKL
                     VH"
     CDS             complement(2214..3290)
                     /locus_tag="ctg49_5"
                     /transl_table=11
                     /translation="VNTFGNIYRLTSFGESHGPGIGGVIDGCPAGIELDTAFIQQELNR
                     RKPGQSRITTPRKEDDEVQFLSGIYEGKTTGTPIGFIIWNKNQHSSDYDNMKTVYRPSH
                     ADYTYQTKYGIRDPRGGGRSSARETIARCVAGAIAKLALKQYGIQIQAYTSQVGPIQLA
                     GSYQDYDLSLTEESDVRCPDPKTASEMETLIAEVKSKGDTIGGIITCVAKGVPVGLGEP
                     VFGKLHAALGHAMLTINAVKGFEYGDGFNAAFFRGSERNDRFFNDNGHINTRTNNSGGI
                     QGGISNGQDIYFRVAFKSVATILMEQETVNMEGEDTILKARGRHDPCVLPRAVPIVESM
                     TAMTLLDYLLIQKTRENF"
     CDS             complement(3394..3969)
                     /locus_tag="ctg49_6"
                     /transl_table=11
                     /translation="MKITANKYVAVTYDLNVGEGEERELMEKATVEAPLKFIYGTGMML
                     PAFEKALNGLEVGGTFNFSIEPAEAYGEYNEEHVLDLPKNIFEVDGKFDAEMIKEGNTV
                     PMMDSNGNRMNGSVLEVKDDIVVMDFNHPLAGETLHFSGEVIDVHEPTAEEIAAFSAPA
                     GGCSCGCDDCGSDCGDNHEGGCGCGGCH"
     CDS             complement(4018..5235)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg49_7"
                     /sec_met_domain="Aminotran_1_2 (E-value: 2e-43, bitscore:
                     138.7, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTPIAIKKLIVNKNMKHYNFDEVIERHGTSCVKFDRLKEMFGDEN
                     LIPLWVADMDFRTPDFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHYKHNWKIQREW
                     ISYIPGIVKGIAFAIQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDGIYE
                     MDFDHLESIIDDKCKVLILCNPHNPGGIVWKKETLVRLAEICTKHNILVISDEIHAEMA
                     YPQYTHYPFASVSDTAASCSVTFMAPSKTFNIAGIVTSYAIVPNDRIREEFYSFLEAGE
                     FGDGTIFAYTATTAAYTYGAEWLQQMRMYIMENVRFVEEFMKLHLPKIKVYQPQASFLV
                     WLDCRELELSQDELVHLFKDKAGLALNDGSIFGPGGEGHMRLNIGCPRSVLDKAMNALK
                     KAVDKK"
     CDS             6331..8166
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_8"
                     /sec_met_domain="ILVD_EDD (E-value: 4.1e-217, bitscore:
                     711.6, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNPLRSSFSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSFT
                     QFVPGHTHLHEIGQLVKAEIEKQGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTVFVSGGPMEAGELDGRHLDLID
                     AMIESADTSVSDERIEQVERHACPGCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     KNRIQLFRDAAKQIVENAYKYYRDGDDSVLPRNIATRQAFLNAMSLDIAMGGSTNTVLH
                     LLAVAQEAGADFHMEDIDMLSRKTPCLCKVAPNTHTYHVQDVNRAGGILGIMNELMKAG
                     LVDGSTRRADGLTLAEAVDKYAVTSPNVTEEAIRKYKSAPAHRFSIQMGSQESYYKELD
                     TDRAEGCIRDVEHAYSKDGGLAVLRGNIALDGCVVKTAGVDESIWKFSGPAKVFDSQDA
                     ACEGILGGKVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHISPEAASGGAIGLVRDGDIIEINIPERSINVRLSDEELAERRKAEEARGKK
                     AFTPPTRQREVSKALRAYGKMVSSADKGGVRIVED"
     CDS             8200..9903
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_9"
                     /sec_met_domain="TPP_enzyme_C (E-value: 9.4e-51, bitscore:
                     161.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYKKVDYVRSYQPEPDIKKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELRAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIAGRAVE
                     KREELDDAIAEMLNHDGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             9919..10473
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_10"
                     /sec_met_domain="ALS_ss_C (E-value: 3.6e-17, bitscore:
                     52.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNEACVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             10480..11205
                     /locus_tag="ctg49_11"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             11255..12298
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg49_12"
                     /sec_met_domain="IlvN (E-value: 2.3e-47, bitscore: 150.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.9e-40, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYDKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(12368..12709)
                     /locus_tag="ctg49_13"
                     /transl_table=11
                     /translation="MEARPTQKQVITSSLFWESYDNVYVQGLDLFGFYQAELYANKIKS
                     ILYELDQTYPYYPECRHLATKSRMYRNIILDSHLIIYRITEERIEVLDIVHSASSMRKI
                     KKTRNIHIE"
     CDS             complement(12676..12912)
                     /locus_tag="ctg49_14"
                     /transl_table=11
                     /translation="MTKLSNIPAKETTAKTAKTRKTKTGPAKLKWDPTKPVQFTQEEIW
                     EHIHEIEKGPFLTLDEGFKRFEAWKQDLLKSRL"
ORIGIN
        1 gcaggctttg aagctcatat ccaagctctt cacggagtga gtcaaagccc ctacggagat
       61 gaagtctacg ccacattccg cgtaatcacg taatgtgtcg aacgtgatac cgccggaaga
      121 ctctacctcg aaacgtccgt tgatgcggcg aaccgcttct tttgtattct cgatattgaa
      181 attatccaac atgatacgat cgataccgcc tactttcatg gcttgttcca actcgtcgaa
      241 gttacgaacc tcgatctcga tctttaggct ctttcctttc tctttcagat agttttgcgc
      301 acgtgtgatc gcctgctcga tgcctccggc gaaatccaca tgattatctt tcaataagat
      361 catatcgaac aaaccgatgc gatggttcat gccgccaccg atacgtacgg cctctttctc
      421 gatcatacgc ataccgggag ttgtcttgcg agtatccaaa acgtgtgtct tggtgccttc
      481 caacgccttg gcgtatttac gggtcgtagt agcgataccg ctcatgcgtt gcataacgtt
      541 cagcatcaac cgctcggtct gcaataagga ttggatctta ccttccacca cgaacgctat
      601 atcccctttt ttcacttcgg ctccgtcttg tataaagacc gtcattttta gttccggatc
      661 gaagtcgtgg aagatacgtt tagccatttc cacgccggcc aatacgccat cttccttgat
      721 gatcagctgg cttttcccca tcgctgtctc ggggatgcaa cataaggtgg tatgatcacc
      781 atcgccaata tcctcggcaa acgctaattt gattaagtcg tcaataagtt tgtccatctt
      841 ttattctatt ctgattgatt gtataatcgc tgtattccct tcggcacggt acgtgatgtt
      901 tacacggtac tcaccggaag acgtcggaag ctttccgaca aggaaaccgc tttccttttt
      961 atccgcatga tgtacgaccg agaatccgga aggcttattc gaactgaaaa atgaggacaa
     1021 catagagacg gcctcacttc cgttacattt cttagaggaa ccgggcaagg ctacatccac
     1081 caccttatcc atagcaccgg atagagagga ggcatttcct gccttgaaag catttgatat
     1141 actggtaata tccgccgcct gcgcacatgc gaatgcgaat atcaaggcga atgtaagtaa
     1201 gagtcgtttc ataagctttc tttattttat tgagtaatta gtggcaaagg tatgtatttt
     1261 tcttgtaact tagcctttct aaacctgtaa atgtaagtag atgaagattg gactgattgt
     1321 gattggtaag acggatgccg gttattttgt ggaggctatc aatgagtata aaaatcgctt
     1381 gacgcattat ataccctttg aaatggaagt cataccggat ataaagaacg tgaagaacct
     1441 ctcagaggcg cagcaaaagg agaaagaggg cgaattgatt ttaaaggctt tgcagcccgg
     1501 cgattatttg gtgttgctgg acgagaaagg gaaggagttc acctccatgc aattttctac
     1561 ttatctggaa aagaaaatgc atacggtccc gaaacgcttg gtatttgtgg tgggcggtcc
     1621 ttacggtttt agtgaggccg tgtataaggc ggcatcggaa aagatctcgt tgagcaagat
     1681 gactttttcc caccagatga tccgattgat ctttatcgag cagatttacc gggcgatgac
     1741 gatcttgaat aacgagcctt accatcatga ataaccgcat cgtttaacgc cggtatccgc
     1801 atagccctac gcctatactg gcgtaagttc acaccgatac tgccgtgagg ctatgcgaat
     1861 actggtgttt ttctcccgga ttaatggact aatttcaggc cgacgatccc tatcaatatc
     1921 aaggataaga acaataatct gaatatattc gcggaatcat ggaaaaacaa gattccaaga
     1981 agaacagtcc ctatagcccc gatcccggtc cagattacat aagccgtacc gatcgggatg
     2041 cttttctggg cgagatataa gaaataaccg cttaagccca tggataagat cgataaacct
     2101 ataaaccaaa taaaatattt ggaatgcata cttgctaatt taaagcccag cggccagccg
     2161 atctcgaata atccggctat aattaacaga atccaagcca tatagaatta gtcttaaaag
     2221 ttttcccgtg tcttctggat caataaataa tccaataaag tcatggcggt catagactcg
     2281 acgataggta ccgcacgagg caatacgcat ggatcatgac gtccgcgtgc ctttaatatc
     2341 gtatcctctc cctccatgtt aaccgtttct tgttccatca agatcgtagc gaccgattta
     2401 aaggctaccc ggaaataaat atcttgtccg ttggagatcc ctccttggat accgccggaa
     2461 ttattggtac gagtattgat atgcccgtta tcattgaaaa agcgatcgtt cctttccgat
     2521 ccgcggaaga aggcggcgtt gaatccgtct ccatactcga agcccttcac ggcgttgatc
     2581 gtaagcatcg catgtcccaa cgcggcatgt aacttgccga acacaggctc tcccaatccg
     2641 acgggaaccc ctttcgccac acaggtaata ataccgccga tcgtatctcc ttttgatttg
     2701 acctcggcga tcaaggtttc catctctgag gcggtcttcg ggtccgggca acgtacgtcg
     2761 ctctcctccg tcaagcttaa atcataatct tggtaactac ccgctaattg gatcgggccg
     2821 acctgcgagg tataagcttg gatctgtatg ccgtattgct taagggcgag tttagcgatg
     2881 gccccagcca cgcaacgagc gatcgtttcc cgggcggacg aacgtccacc tccacgggga
     2941 tcacggattc catatttcgt ttgataggta taatcagcat gggaaggacg gtaaaccgtt
     3001 ttcatattgt catagtccga ggaatgttgg tttttgttcc agatgatgaa acctatcggc
     3061 gtaccggttg tctttccctc gtagatgccg gaaagaaatt gtacctcatc atcctcttta
     3121 cggggggtcg tgatacggga ttgtcccggt ttacgacggt tcagctcttg ctggatgaat
     3181 gccgtatcta attcgatccc ggctgggcat ccgtcgatca cgccgccgat accggggccg
     3241 tgcgattcgc cgaacgatgt taatctataa atattaccaa aagtattcac cgttttgtct
     3301 aattgaaaat tgaaaactga aaattgagaa tcaaaagccg atgattaggc acttctccta
     3361 attttcaatt ttcaattctc aatttcccat tatttagtgg catccaccac aaccacaacc
     3421 accctcgtgg ttatcgccac aatcgctacc gcaatcgtcg caaccgcaac tacatccacc
     3481 tgcgggagcg gagaaggctg cgatctcttc cgctgtcggt tcgtgtacgt cgattacctc
     3541 gccgctgaaa tgcaaagtct cgccagccaa cggatggttg aagtccatta ccacgatatc
     3601 atccttcact tccaatacag agccgttcat acggttgcca ttagaatcca tcatcggtac
     3661 ggtattacct tccttgatca tctcggcgtc gaatttaccg tccacctcga agatattctt
     3721 cggaagatcc aatacgtgct cctcgttata ttcgccataa gcctcggctg gctcgatgga
     3781 gaagttgaac gtgccaccta cttccagccc gttcaaggct ttctcgaatg ccggaagcat
     3841 catgcctgtt ccgtagatga atttcaaagg agcctcgacc gtcgcttttt ccattaactc
     3901 acgttcttca ccttcgccaa cgttcaggtc gtatgtaacc gcaacgtatt tgtttgctgt
     3961 aattttcatt tgtcttgtat tttaaatatg tatagaaatg ctcgcaaaga tacgatttta
     4021 tttcttatcc accgcctttt taagagcgtt catcgcttta tctaaaacag agcgggggca
     4081 accaatgttc aaacgcatat ggccttctcc cccgggaccg aagatacttc cgtcgttcag
     4141 cgctagtccg gctttgtctt tgaacaggtg tacgagttca tcttgactta attccagttc
     4201 cctgcaatcc aaccaaacga ggaaggaggc ttggggctgg taaactttta tcttggggag
     4261 atgtagtttc atgaactctt ccacgaaacg tacattctcc atgatataca ttcgcatttg
     4321 ttgcaaccat tcggcgccat aggtgtaagc ggcggttgtc gccgtataag cgaagatcgt
     4381 gccatcgcca aactctccgg cctcaaggaa agagtaaaat tcttcccgga tgcgatcatt
     4441 gggtacgatt gcgtaggaag tcacgatacc ggcgatattg aacgtcttgc tcggtgccat
     4501 gaaagttacg ctgcaagaag cggcagtatc cgatacggag gcaaatggat aatgcgtata
     4561 ctgaggatag gccatttccg catgaatctc atcggagata accaaaatat tgtgcttggt
     4621 gcaaatctcg gccaatcgga ccaaggtttc ctttttccag acgatcccgc ccggattgtg
     4681 agggttgcag aggatcaata ccttgcattt atcatctata atagattcaa gatgatcgaa
     4741 atccatctca tagatgccgt ctaccatctt tagcggatta taaacgacct cacgcttcat
     4801 tttctccgga acgatgcgga acggatgata aacagggggc tggatgatga ccttatctcc
     4861 tttttgcgta aagcattgga tagcgaaagc gattcccttt acgattcccg ggatatagct
     4921 gatccattcc cgttgtattt tccagttatg tttgtagtgt acccaattga tgatactctc
     4981 gtaatactcg tcggagccga atgtatagcc gaatatctcg tgctcacaac gtttcttcag
     5041 ggcctctaca ataaagtccg gtgtgcggaa atccatatcc gccacccata gtggtatcag
     5101 attctcgtca ccgaacatct ctttcaaacg gtcgaatttc acgcaactcg tcccatgccg
     5161 ttcgataact tcgtcgaagt tgtagtgttt catattttta ttaacgatca gtttcttaat
     5221 tgctattggg gtcaaagata caaattatta tatttattgt ttatccaaat caaagtatga
     5281 aatgctgtat attaggaaat cggcgatata tttaatgaat cgtttactta aatggcttat
     5341 caaaccgtga actggcaaaa tgtcaaagtg ttattattgc tctctgtggg tgatgaatta
     5401 tggggcgggg gcttggtcgc acggaaaaag cgcaagcatt tgatggttgt gtaaatcaga
     5461 atgatgtttg aatgcaggtg ttgttggtct tttttatgat tgatgtttga atagctgtct
     5521 atcggttgag tatttaaggc tttctctgtc tgaaagtcat tttgaaaatg tctttgcttg
     5581 agctgcttct agcgtgggtt atgccggatt tagtcttgat tttaggtgat tttcattcga
     5641 atgttaacaa aatttagtcc gatactagat gaaatttatt ccttatgttc ttcagaaaac
     5701 ttccttatgt tttttctaga acactattat gaattttttc aaggctattt atagtctaca
     5761 agtgttaata aatatgtgat ttagagttta tatgtatctt ttttatcgct agaataggat
     5821 tttcttatga gatacgtgtt atcgtaagtc gtgttatctg ataaaaatgt tatctggaat
     5881 ctgttttaga taacatttgt ctttttactg tttcnnnnnn nnnntgtttc tgtttggaaa
     5941 tcgaagtttt ttcccttcta taccttccga ttcctaagta atacactctt gctcctgtta
     6001 aaatgcaatc ctaaaatggt atttgcttga gaattgaaag aaaaatgaag aattttcttt
     6061 taaatccttt gcgcatatca attattgttc tacatttgca gcgtcaaaca aacaaagaca
     6121 ataagaaaag atgatgaaca acgtattgca tattattctc gtggtggtcc ttctagtcat
     6181 tagtaggtaa ggagaaaggt gtgtaagaag ttgtgaagtc gtagagatat ttcttaagcc
     6241 tttctccata tagggaaagg cttttttatt ataaataaat caaggtagag gcgtggataa
     6301 agcgctctac gaacaaaaaa taggaaagag atgaagaatc cgttaagaag ctcatttagc
     6361 accgaaggtc gtaggatggc cggagcccgt gcgctatggc gtgccaacgg gatgaaagag
     6421 gaacagttcg gcaagcctat tatcgctatc gtaaattcat ttacccagtt cgtgccgggg
     6481 catacgcatt tgcatgagat cgggcaactg gtcaaggccg agatcgagaa acaaggttgt
     6541 ttcgccgctg aatttaatac gatcgctatc gacgacggta tcgctatggg gcacgatggg
     6601 atgctttact cgcttccttc acgcgacatt atcgcggaca gcgtggaata tatggtaaat
     6661 gcccataagg cggacgctat ggtttgcatc agcaattgcg ataagatcac gccgggtatg
     6721 cttatggctt ccatgcgatt aaatatcccg acggtgttcg tgtccggtgg cccgatggag
     6781 gcaggtgagc tggatggccg ccatctggat ttgatcgacg cgatgattga gtccgccgat
     6841 acatcggtaa gcgatgagcg tatcgagcag gtggaacgcc atgcgtgtcc gggttgcggt
     6901 tgttgttccg gtatgtttac cgctaactct atgaactgct tgaacgaggc gatcggtctg
     6961 gcgcttccgg ggaacgggac gatcgtggct acccataaga accgtatcca acttttccgt
     7021 gatgcggcta agcaaatcgt tgagaacgct tacaaatact atcgtgacgg ggatgattcc
     7081 gtgttacctc gcaacatcgc tacccgtcag gctttcttga acgccatgtc gctggatatc
     7141 gccatggggg ggtctaccaa tacggtgctt cacttattgg ccgtggcaca agaagccggc
     7201 gccgattttc atatggagga tatcgatatg ttatcccgca agacaccttg cctgtgtaag
     7261 gtagccccga atacgcacac ttatcatgta caagacgtaa accgtgccgg tggaatcctc
     7321 ggtatcatga acgagttgat gaaagccggg cttgtggatg gcagcacgag acgtgcggac
     7381 ggcctgacct tggccgaggc tgttgataaa tacgccgtca cttccccgaa cgtaacggag
     7441 gaggcgatcc gtaaatacaa gagcgctccc gctcatcggt tcagtatcca gatgggttcc
     7501 caagaatctt attataagga attagatacg gatcgtgccg aaggttgtat ccgtgacgtg
     7561 gagcacgctt attccaagga tggcggcttg gctgttttga gagggaatat cgccttggac
     7621 ggatgtgtcg taaaaaccgc cggcgtggat gagagtattt ggaaattctc cggcccggcg
     7681 aaagtcttcg attcacagga tgccgcttgc gagggcattt taggaggcaa ggtcgtttca
     7741 ggcgatgtgg tcgtcatcac gtatgagggt ccgaaaggag ggccgggaat gcaagagatg
     7801 ttatatccta cctcttatat aaagagccgt cacttaggta aggagtgcgc cttgatcacg
     7861 gatggtcgtt tcagtggcgg tacgtccggt ctttctatcg ggcatatctc tcctgaggcc
     7921 gcttccggtg gcgctatcgg actggtgaga gacggggata tcatcgagat caatatcccg
     7981 gaacgttcca tcaacgtgcg gctgagcgac gaggagttgg ccgagcgccg taaagcggaa
     8041 gaggcgcgtg gaaagaaagc ctttacgccg ccgacgcgtc agcgtgaggt ctcgaaagcg
     8101 ttgagagcgt acgggaagat ggttagctcc gccgataagg gaggtgtaag gattgttgaa
     8161 gattaaagcc aataatatac attaaacacg ttatttctta tggagaaaca aaagataacc
     8221 ggttcggaag ctttgctgaa agcgttgatt gctgaaggag tagatactat cttcggttat
     8281 cccggcggac aggcgatacc tatttacgac agtttatatg attataggga ccagttgagg
     8341 catgtattgg tgcgccacga gcaaggcgct acccatgcgg ctcaaggata tgcccgtgta
     8401 tccggcaagg taggagtgac gttggttact tccggcccgg gcgctacgaa taccatcacg
     8461 ggtatcgctg atgcgctgat ggatagtacg ccaatggtcg taatcgccgg tcaagtaccc
     8521 tcgccgttgt tgggaaccga tgcttttcag gaagtcgacg tgattggcat cacgcaaccg
     8581 atcacgaaat gggcttatca aatccgcaag ccggaggaga tcgcatgggc tgtttctcgt
     8641 gctttttata tcgcttctac aggccgtccg ggtccagttg tgctggattt agcgaaggac
     8701 gcgcaagtag ggctggtgga ctatgaatat aagaaggtag attacgtacg tagttatcag
     8761 ccggagccgg atatcaaaaa ggatcgtatc aaggccgccg ccgatttaat caatgaggcg
     8821 aagaaaccct tctgtctggt cgggcaggga gtattgttag gcggtgcgga agaggaattg
     8881 agagcgtttc tccaaaagaa tgatatacct gccggatcta cggtattggg cttatctgcg
     8941 ttgccaaccg atttcccatt gaacaaggga atgctcggta tgcatggaaa cgtagggccg
     9001 aaccggaaaa cgaatgagtg tgatgtattg atcgctatcg gtatgcgttt cgacgaccgt
     9061 gtgactggcg atttaaagac atacgctaag caagccaaga ttatccatct ggatatcgac
     9121 aactcggaaa tcggtaagaa cgtccccgta gatgtaaagg tgctgggtaa tgccaagcac
     9181 acgataccga tgatcacggc gttgttggaa gaacgtaaac gtccggaatg gaatgccgag
     9241 ttcgatcggg acgagaaaga ggaatacgat aaggtaatcg agaaggaatt gtatccgacc
     9301 gagggccaac tgaaaatggg cgaggtagtc cgtaaggttt ccgaggcgac cggtaacgac
     9361 gctgtattgg tgaccgacgt tgggcagaac cagatgatgg gtgtccgcta tttcaaatat
     9421 aaacaaaccc gtagcgtggt gacttccgga ggtttaggta cgatgggatt tggtctgccg
     9481 gccgctatgg gcgctaagtt cggggctccg gaccgtacgg tctgcttctt taccggtgat
     9541 gggggtatgc agatgacgat tcaggaattg ggtaccatca tgcaggagaa actgaacgtg
     9601 aagattatca ttcttaataa taacttctta ggtatggtac gtcagtggca agaattgttc
     9661 ttccacgagc gttattcaaa caccatcatg gagaatccgg atttcgtggc gatcgctaaa
     9721 gcctatggta tcgctggccg tgccgttgaa aagcgggagg aattggacga cgctatcgcc
     9781 gagatgctaa accacgacgg cgcttacgtg ttggtcgcta acgtggagac ttgcggaatg
     9841 gtatatccga tggttcctgc cgggggaagc gtgacaaaca tgattatggg agacgagaaa
     9901 taaggaggag atgaagctat gacaacaaag aaattatata ccgttattat cttttcagag
     9961 aatatcgtag gtcttttgaa ccagataacg attatcttta cacgccgaca gctgaacatc
    10021 gagactctgt ccgtctctcc gtccgctatc aagggcatcc ataagtttac gatcacgacc
    10081 ttcgccgatg aggatatgat cgataaggtg gtgaaacaga tcgataaacg tgtggatatc
    10141 ttgaaggctt attataatac ggatgaggat ctggtttatc aagagatcgc cctttataag
    10201 ctaagtaccg agcttttcat caagatggga accgtggagg gattgatccg taaatacaac
    10261 gctcgtatct tggagatgaa cgaggcctgc gtggtgttgg agaagagtgg ccactatgac
    10321 gagacacaag ccttgttcaa tgagttgagc gagacgatcg gtgtcctgca attcatccgc
    10381 tccggacgtg tggctatcac gaagagcaag gtggagcgct tgagcgatat gttggccgat
    10441 atggagcgaa agttacatga aaagcaacaa taataagata tggagaaagt aggattattt
    10501 catttcgtgg cggagccgta tttgatggat ttcaggggac gtgtaacgct ccctatgatt
    10561 ggtaactatt tgattcacgc cgcttccagc catgccggag agcgtgggtt cggtttcaat
    10621 gatatgtcgg agcgtcatac ggcttgggtg ttgtcccgtc tggctatcga gatgaaggaa
    10681 tatcctaccg ccttcgataa gattaatcta tacacttgga tcgatgaggt cggacgcctc
    10741 ttcaccagtc gttgtttcga gctggcggat gagaatggga aaacctttgg attcgcccgt
    10801 tctatttggg cggctatcga cgtggagacc cgccgtccta ccttattgga tatagaggca
    10861 ttgggcaaat atatcgacga gcgtccgtgc ccgatcgaga agccgggcaa gatcatgccg
    10921 gcggagaata aggcggaggg aatcccgtat tcgatcaaat acagcgactt ggatataaac
    10981 ggtcacttca atagcgtgaa gtatatcgag cacctgctgg atttgttcga tatcgatcag
    11041 ttcaagaccc gtgagatcgg ccgtctggag atcgcctacc aatccgaggg taaacaaggt
    11101 atgccgctta cgcttcataa ggcggagtcc gctcccgata agcaagacat ggctatttgc
    11161 catgagggaa aggcgatctg tcgtgcggcg gttacttgga gataataaaa gagatacata
    11221 aataggtttt taaacattaa tagttaaaaa gaaaatggca caaatgaatt ttggcggtgt
    11281 tgtagagaat gtaatgaccc gcgaggaatt tccgttggaa aaggcaagag agatattaaa
    11341 agatgagaca atcgctgtta tcggctatgg cgtacaggga ccgggacagt cattgaacct
    11401 tcgtgacaat ggcttcaacg taatcgttgg ccagcgccaa ggtaagactt acgataaagc
    11461 ggttgaggac ggatgggttc cgggtgagac tctgttcggt atcgaggagg cttgcgacaa
    11521 ggccacgatc atcatgtgct tgttgtccga cgctgccgta atgtctgtat ggcctacgat
    11581 gaagccttat ttgacagctg gcaaggccct gtatttctct catggttttg cgatcacttg
    11641 gaacgatcgt acgggcgttg ttcctcccgc ggatattgac gtgatcatgg tcgctccgaa
    11701 ggggtctggt acgtctttgc gttccatgtt ccttgagggt cgtggcttga actcttcttt
    11761 cgctatctat caagacgcta ctggcaaggc gatggatcgt acgttggcgt tgggtatcgg
    11821 tatcggttcc ggctacttgt tcgagacgac tttcatccgt gaggctactt ccgatttgac
    11881 tggtgagcgt ggttccttga tgggcgctat ccaaggtttg ttgttggccc agtatgaggt
    11941 attgcgcgag aatggacata ctccttccga ggctttcaac gagacggtcg aggagttgac
    12001 tcaatccttg atgcctttat tcgccaagaa tggtatggac tggatgtacg cgaactgctc
    12061 tactaccgcc cagcgtggcg ctttggactg gatgggtccg ttccacgacg caatcaagcc
    12121 ggttgtcgag aaattgtacg caaacgtaaa atgcggtaac gaggctcaga tctctatcga
    12181 ctcaaactct aagccggatt atcgtgagaa attggaggct gaattgaagg cattgcgcga
    12241 gagcgagatg tggcagacag ctgttactgt acgtaagctt cgtccggaga acaactaatc
    12301 caatcttaat ccttatatat cagcaaaaag aggcgggtca cttacgggtg gctcgccttt
    12361 ctttgtgtta ttcgatgtgg atattcctag tcttcttgat ctttcgcatg ctggatgctg
    12421 aatggacgat gtccagcacc tcgatgcgtt cctcggtgat gcggtagatg ataaggtgtg
    12481 aatctaggat gatgttccgg tacatgcggc ttttcgtggc taggtgtcgg cattcgggat
    12541 aataaggata ggtttggtct aactcgtata agatggattt tatcttgtta gcgtataatt
    12601 ccgcttggta gaatccaaat aagtcaaggc cttgaacata tacattatcg taactttccc
    12661 aaaataaact actggttata acctgctttt gagtaggtct tgcttccatg cctcaaaacg
    12721 tttaaaacct tcatctaggg ttaggaacgg tcccttctca atctcatgga tatgttccca
    12781 gatctcttct tgggtgaatt gcaccggctt ggtgggatcc cacttgagct ttgcgggtcc
    12841 ggtcttggtc ttacgtgtct ttgcggtctt ggccgtagtt tccttggcgg ggatgttgct
    12901 taattttgtc atagtcgtaa tcgttattaa ttagtactgt ggcaaatgta tggaataatt
    12961 tccatgtaat aagatatttg gtaaggaaaa aagtaggtct ataggattaa ctcattaccc
    13021 agttgtagag acggggcgtg ccccgtctcc atcccctcaa aatggtattc aaatttattt
    13081 atgtcacata accgctattt ttaatcgctt atctgctata tacgcacaat aagcatgaat
    13141 tttggggtgt ggggtgtgca ggtctttatt acatattttt ttatttctta tatttactac
    13201 gtcttataca ttaaaagagt atatgaaaat catatgatga tgtgtgatag atatataatg
    13261 ttaacctttt ttatcagtat gcgtttggtg aatcggaata attgtgtagc aagcaagcaa
    13321 gcaagcaagc aagcaagcaa gcaagcaagc aagcaagcaa gataacccag atctattata
    13381 tgtatacgcc gggccggtat gcggaggatt tcctcc
//
