LOCUS       c00048_gnlPro..        12771 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MLBNNDOO_48.
ACCESSION   c00048_gnlPro..
VERSION     c00048_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 07:09:05
            Original ID  :: gnl|Prokka|MLBNNDOO_48
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12771
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1380
                     /locus_tag="ctg48_1"
                     /transl_table=11
                     /translation="GTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGTG
                     KTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLSF
                     TYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRATALEIQIN
                     AELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQALEAACWIAIRKADRVVLAGDH
                     CQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQYRMHEEIMKFPSQWFYNGEL
                     EAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGRINKAEADLLLSELKIYINRI
                     GGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYRSLFTVNTVDGFQGQERDVIF
                     ISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAETLKHHGFYRKLLEFIQNIGN
                     Q"
     protocluster    1..12771
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1441:7523]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1442..7523
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12771
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12771
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(1442..2485)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_2"
                     /sec_met_domain="IlvN (E-value: 3.8e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 3.5e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIIMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(2536..3288)
                     /locus_tag="ctg48_3"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(3285..3845)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_4"
                     /sec_met_domain="ALS_ss_C (E-value: 6.1e-20, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(3878..5629)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 8.5e-48, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAKRPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(5721..7523)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_6"
                     /sec_met_domain="ILVD_EDD (E-value: 5.5e-219, bitscore:
                     717.3, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKHQLRSSFSTQGRRMAGARALWTANGMKKEQMGKPIIAIVNSFT
                     QFVPGHVHLHEIGQFVKEEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIADS
                     VEYMVNAHKADAMVCISNCDKITPGMLMAAMRLNIPTVFVSGGPMEAGEWNGQHLDLID
                     AMIKSADESVGDKEVAQIEQHACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTIVATH
                     ENRKRLFEDAAKLIVANAFRYYEEGDESVLPRSIATREAFLNAMTLDIAMGGSTNTVLH
                     LLAVAHEAGADFKMDDIDMLSRKTPCLCKVAPNTQKYHVQDVNRAGGIIAIMDELAKGG
                     LVDTNVRRVDGMTLAEAIDRYSITSSNVCKEAIKKYSSAAAGKFNLVLGSQNASYKELD
                     TDRATGCIRDLEHAYSKDGGLAVLKGNIAQDGCVVKTAGVDESIWKFTGPAKVFDSQDA
                     ACDGILGGKVVSGDVVVITHEGPKGGPGMQEMLYPTSYIKSRHLGKECALITDGRFSGG
                     TSGLSIGHVSPEAAAGGNIGKIKDGDIIEIDIPNRSINVKLTDEELAARPMTPVTRNRE
                     VSKALKAYASMVSSADKGAVRLID"
     CDS             8014..8535
                     /locus_tag="ctg48_7"
                     /transl_table=11
                     /translation="METVENKYITVAYKLYSIENGEKDFEEEAPVEHPFQFISGLGMTL
                     EPFEAQIKDLQIGDKFDFTIPASEAYGEYDDDHVIDLPKEIFMIEGEFDSDRVVEGAVI
                     PLMTSEGQRINGSVVEVKEDVVVMDMNHPLAGCDLNFTGEVVESRPATNEELAEVARMM
                     XXXXDGWRLW"
     CDS             complement(8710..9987)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SDH_alpha"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_8"
                     /sec_met_domain="SDH_alpha (E-value: 1.5e-62, bitscore:
                     201.0, seeds: 645, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTETERRQIIALVKSEVIPAIGCTEPIAVALCVAKAAEVLNKRPE
                     KITVLLSANILKNAMGVGIPGTGMIGLPIAVALGALIGKSAYQLEVLKESTPDAVEAGK
                     RFIEEKRIHISLKNDMEEKLYIEVCCEADTDKATAIIAGGHTCFTYITRNGDILLDKQI
                     ASCIEEEDVLDLTLRKVYDFAMTTPLDDIRFILETARLNKAAAERSFEGDYGHGLGKIL
                     RGTYEHKVMGDSVFSHILSYTSGACDARMAGAMIPVMSNSGSGNQGISATLPVLIYAEE
                     NGKSEEELIRALMLSHLTVIYIKQSLGRLSALCGCVVAATGSSCGITWLMGGTYEQVAY
                     AVQNMIANLTGMICDGAKPSCALKVTTGVSTAVLSAIMAMENRCVTSVEGIIDEDVDQS
                     IRNLTKIGSKGMNETDKLVLEIMTSK"
     CDS             complement(10107..11300)
                     /locus_tag="ctg48_9"
                     /transl_table=11
                     /translation="MKKNLFYLFALICSMSLFTACSDDDDDKVVCPVPQTEFTVATGLN
                     LTYNGGSMLGKKVTFTPDASDATKATLVLAGNLDLSGILTREAASGSFGAGVFPGSPVV
                     TLPVTLNIQGDECSFSGTSETDYCTFDYAGKVTASSLKLDLTNVALKNSALSGTTWVPT
                     PLNSDYTEEPIHLIWESNKNVEVMPGWELPIQTILTLALRMPLIDAGGDDKVNVEDMLC
                     SVLHDITLGADGNISASYVDAAQGGTSVVKTPANVAQYVVLSDTQMKVYLNLDAIIANV
                     KRLGSSTKAIDMSEILSQAVTSLLPLVTDGVPLTYEKNEGKLKAYLNTDLLLPLMKNIV
                     APLFSDEEFVNMLIEAMKADPDFGSMAGMAEGMLKGLPEIINETTRLEVGLNLTAAK"
     CDS             11675..12751
                     /locus_tag="ctg48_10"
                     /transl_table=11
                     /translation="MFNSFGNILRLTSFGESHGKGVGGVIDGFPAGIVIDMDFVQAELD
                     RRRPGQSRITTARKEGDKVEFLSGIFEGKSTGCPIGFIVWNQNQHSDGYNNLKEVYRPS
                     HADYTYKVKYGIRDHRGGGRSSARETISRVVAGALAKLALKQLGIHITAYTSQVGPIRL
                     EENYTAYDLDLIETNPVRCPDPAKAKEMEELIFKIKGEGDTIGGVVTCVVKGCPIGLGQ
                     PVFGKLHAALGAAMLSINAAKAFEYGDGFKGLKQKGSEQNDVFYNNNGRIETRTNHSGG
                     IQGGISNGQDIYFRVAFKPVATVLMEQHTVNIDGVDTTLKARGRHDPCVLPRAVPIVEA
                     MTAMTLLDYYLIDRTTQL"
ORIGIN
        1 ggaacctcga aagccggttt ccgagagctc tatcccgtac ggtttccctg gctgaactcc
       61 acgcaggaga cagctgtaaa caaagtgctg tgtgcccgcg acgtggccat tgtacacggt
      121 cctccgggaa ccggaaaaac gaccacctta gtggaagcca tctacgaaac cctgcatcgg
      181 gaaccgcagg tactggtatg tgcccaaagc aatactgccg tcgactggat ttcggaaaaa
      241 cttgtggacc gtggcgtcaa tgtcctgcgt atcggcaatc cgacccgtgt caacgacaag
      301 atgctttcct ttacctacga gcgtcgtttc gagaaccatc cgctttatcc ggagctgtgg
      361 agcatccgga aaaatctccg tgaactgggc agccgtgccc gccgtggcag ctatgacgaa
      421 cgcgaaggag tacgcagccg tatgagccgc ctgcgcgacc gcgccaccgc attggaaata
      481 caaatcaatg cagagctttt tgatggggca catgtcatag cctccacgct agtaagcagc
      541 aatcaccggc tgctgaacgg acgccgtttc ggcacccttt tcattgatga agcagcccag
      601 gccttagaag ctgcctgctg gatagctatc cgaaaagcag accgcgtggt gttggcgggt
      661 gaccactgcc aacttccgcc cactataaaa tgctacgaag ctgcccgtgg aggtctggaa
      721 cgaacattga tggagaaagt ggtgtccaac aaacctgccg ttgtctcttt gctgaaagta
      781 caataccgca tgcacgagga aatcatgaaa tttccttccc aatggtttta taatggcgag
      841 ttggaagccg ctcccgaagt gcgttaccgg ggcatcctgg actgggatac ccccatccac
      901 tggattgaca cctccgaaat ggatttcaaa gaagaatttg tgggagagac tttcggacgc
      961 attaataagg cggaagcgga cctgctccta tcagaactga aaatctacat caaccgtatc
     1021 ggtggcaacc gcattctgga agaaaaaata gacatcggca tcatctcccc ttacaaggca
     1081 caagtgcaat atctccgcag caagataaag gcagacgctt cactcaagcc ttatcgcagc
     1141 ttgttcactg taaatacggt ggatggcttc caagggcaag agcgcgatgt tatcttcatc
     1201 agccttgtcc gtgccaacga agaaggacag ataggattcc tgaatgattt aaggagaatg
     1261 aatgtagcca tcacccgggc acgtatgaag ctggtgatat tgggagaggc agagacgctg
     1321 aaacatcacg gtttttaccg gaagctattg gagtttattc aaaatatagg gaatcaataa
     1381 taaagaaata ccccctccgg taacaccgaa gagggtattt cacctattta tataaagctg
     1441 attaattgtt ttccggacga agtttacgaa ctgtaacagc tgtctgccac atttcgcttt
     1501 cacgcaaggc tttcaattct gcattcagct tctcacgata atcgggtttg gagttactgt
     1561 cgatagaaat ctgagcttcg ttgcccgact tcacacttgc atacaatttc tgtacaaccg
     1621 gcttgatggc atcatggaac ggggtcatcc aatccagcgc accacgctgt gccgtagtag
     1681 aacagttggc atacatccag tccataccgt tcttggcaaa caatggcatc aaagattgag
     1741 tcaactcttc cactgtttca ttgaatgctt cagaaggagt atggccgttt tcgcgcaata
     1801 cttcatactg agccaacagc aatccctgga tagcacccat caatgaaccg cgttcaccgg
     1861 tcaagtcgga agtggcttcg cggatgaaag ttgtctcgaa caaatatccc gaaccgatgc
     1921 cgatacccag tgcaatcgtc ttgtcaaaag ccttacccgt agcatcctga tagacggcat
     1981 atgatgagtt caagccacga ccctcgagga acatggtacg aagtgaagta ccggaacctt
     2041 tgggagcaac cataataaca tcaatatctt taggaggaac cacgccggta cggtcgttcc
     2101 aggtaatagc aaaaccatga gagaagtaaa gagcctttcc gggagtcaaa taaggtttga
     2161 tagtcggcca tacagacatt acagctgcgt cagacaacag acacatgatg atagtacctt
     2221 tctgacaagc ctcttcgatg ccgaacaaag tctcacccgg tacccatccg tcagccacag
     2281 ccttttcgta tgtcttaccc ggacgttgtc ctacaatcac attgaaaccg ttatcacgca
     2341 agttgcaagc ctggcccggg ccttgtacgc cataaccgat tactgcaatt gtttcatctt
     2401 tcaaaatctc acgtgctttt tccaaaggaa attcttcgcg ggtcattaca ttctcaataa
     2461 caccgccaaa attcaattgt gccatttttt gttttaattt ttatttgtgg cttacgccaa
     2521 cgttgataaa tttatttatt tctctgtaaa tatcacttta gagcgacaga ccacttcgct
     2581 gccattcttt ttcacctcca catcgtaaac gccctcaccg gcatcatcca tgaacaaagt
     2641 caactcatcc ccataatagc tttcggctac atatgccatt tcaaaacgac ggatgcgctt
     2701 ctccttatac atctctatcg ggaacaaatc aaggatatgc tcgatgtaac ggatgctgtt
     2761 cacatgcccg ttaatgtcaa tatcactgta tttggctacc aaagcagcaa ccggttcctt
     2821 tgaggccacc tttatccgcg aaggtttttc tatcgggcaa ggctcatcgc aaacataatc
     2881 tacaatgctg ccactatgaa gagccagcaa atctgccggc ttacgggtat tcatgctaat
     2941 catcgcccaa acggaacgtg catacccaat cttcttaccc tccttatcga tgatagcgaa
     3001 attacggtct gtaaaaaggc gatagacatt ctccacccaa gtctgaatgg agaaatcttc
     3061 gtactgataa ggcatttcat ccagttcgac agccagacgg gacaataccc aagtataatt
     3121 gtcctcgttt agagtcgcga tgccaaaacc gcggtcgctg gcatggaaac ccgcacaatt
     3181 caacaaatgg ttgcccaata ctcccattgt cagccgtccg gtaaagtcga catgaaacgg
     3241 ttcggcaaca aacttgtagg tacctatttt attgttctcg ctcatcatga ttcctggtgt
     3301 ttactttgac gatattttgc ttcacggtcc gccagatatt cattgacacg ctcaaagcag
     3361 ctggtcgtaa tggctacgcg acccgaacgg acgaactgaa gtacgcaatc caactggcgc
     3421 aactcctcat aaagattggt tatttcctca ctcatgccat tcttctcaac aatggcaaat
     3481 acagcattca cctccacaat acgggcattg tacttacgga ttactttgga cacctccggt
     3541 ttttcttcca gcgtaggggt cgttatttta taaagggcaa tctcgtgctg atagatttca
     3601 tcatccgtga aataatgggc ttgcagcaca tctattttct tggtaatctg cttggtcacc
     3661 ttttcaatgg tatccttatc cgtccaagcg gtaatggtat atttatgtac ccccttgatg
     3721 gaggaggccg atacattcaa actctcgatg tttatctgcc ggcgggtaaa cacagccgtc
     3781 acctgattca gcaaaccggc aaagttttcc gaatgaacaa tgattgtata tagtttttta
     3841 tccatagata gagtaaattc tttaatttcg catgacttca gcattccaac aacatctgat
     3901 tgaccgaacc gcccggaggt gtcatcggca ttacatttcc ttcttcctcc acacaagctt
     3961 cgagcaggaa cggtccgtca gtcgctatca tctcgtcaat cgcttttgcc agctcctcgc
     4021 gggtcattac cctgcgtgca ggaatatcat atgccgaagc aatcttcata taatccggat
     4081 tcatcatcgg agtaaacgaa taacgacgat tgaagaacat cgcctgccat tgacgaacat
     4141 tgcccaagaa gttattgttc aacagaatca tcttcaccgg agccttttgt tccatgatgg
     4201 tacccagttc ctgcaggttc atctgcaagc cgccgtctcc catgaatacg cataccgtgc
     4261 ggtccggacg tccaaaagtg gcaccgatag ctgccggaag gccgaagccc atagtaccca
     4321 ggccaccgga agtaacaatg ctacgttcct tgctgtattt gaaataacgg gcggacatca
     4381 tctgattctg gccgacatca gtcaccaata tcgcctcgtt atgggtagcc tcactcacag
     4441 cacgcaccac ctcacccatg cttagcgctt ttcctgccgg atgtaattcc ggacggatta
     4501 ccttttcctc ttccacttcc tcgtattgcc ggaaactgtc aatccattcc tgatggttgg
     4561 cgggttccag caattgggta acggcagcca gtgtctcttt gcaatctccc aggacagcaa
     4621 catcagtctt tacattctta tctatttcgg cagggtcaat atcaaagtgg ataatcttcg
     4681 cctgcttggc atatgtttcc aatttacccg tcacacggtc atcaaagcgc atgcctacgg
     4741 cgataaggac atcacattta ttggtattga tattgggccc caggttaccg tgcataccaa
     4801 gcattccttt gttcaacgga tggttcgtag gtaatgcgga aagtcccaat aaagtgcatc
     4861 cggcaggcat tccggctttc tcaatgaaag cacgaagctc ttgctgggct tctcccagct
     4921 ccacgccttg tccaaccagc accaaaggcc gtttcgcacc atttattaat tcagcagcct
     4981 tccgtatggc ctccggctcc atttcgggaa cgggaagata gctacggaca tagtccacct
     5041 tagtaggcgc atattctgtt ttctccactt gggcgttttt agcaaaatcc agcacgaccg
     5101 gtcccggacg tccgctcttt gccacataga aagcacgtgc cactgcccag gccacatctt
     5161 ctgcacgacg aatctggtaa ctccatttcg tgataggctg agtaatgcct accaagtcca
     5221 cttcctgaaa tgcatccgta cccaagaagt tcgtccctac ctggccggca atgacaacga
     5281 taggcgtact gtcaatcatg gcatctgcaa tgcccgtgat agtattggta gcacccggtc
     5341 cactggtaac cagacaaacg ccaacctcgc ctgatacacg tgcaaagcct tgtgccgcat
     5401 gggttgctcc ttgttcatga cgaaccaaga tgtggttcaa ttccttccga tggtcgtata
     5461 aggcatcgaa taccggcatg atgctccctc ccggataacc gaaaatagtc tttactccct
     5521 gatgctccag agagcgcatc aatgcttctg cgcctgttat tagagcctca ccccgaccct
     5581 ctccttggga gagggaggaa aagttactct ttttattatt atcagccata ctttatctat
     5641 tcattatatt taaaagctca atagtagctt gaaaaatttg tttcattctc tcctcccctc
     5701 gctttcggaa aggggggctt ttaatcaatc agcctcacag cccctttgtc agcggaactc
     5761 accatactgg catatgcttt caatgctttg gagacttcac ggttgcgggt taccggagtc
     5821 atagggcgtg ctgcaagctc ttcatccgtc aacttcacat tgatagaacg gttcggtata
     5881 tcaatttcga taatgtcccc atccttaatc ttgccgatat taccaccggc agccgcttcg
     5941 ggagaaacat gtccgatact tagtccggaa gtaccgccac taaaacgccc gtcggtaatc
     6001 aatgcacact ccttacccag atggcgggat ttgatataag aagtaggata aagcatctct
     6061 tgcatacccg gtccaccttt cggcccttcg tgagtgatga cgacgacgtc tccactgacc
     6121 acctttccac ccagaatacc gtcacaagcc gcatcttgtg agtcgaagac tttcgctggc
     6181 cccgtaaatt tccagatact ctcgtctaca ccggcagtct tgacaacgca accgtcctga
     6241 gctatatttc ccttcaaaac cgccagaccg ccatccttgc tgtatgcatg ttccaaatca
     6301 cggatacaac cagtcgcacg gtccgtatcg agttccttat aagacgcatt ttgtgagccg
     6361 agtaccagat tgaactttcc ggctgccgca ctggagtatt tcttgattgc ctctttacat
     6421 acattagagc tggtaatact ataccggtcg attgcctctg ccaacgtcat tccatccaca
     6481 cggcggacat tcgtatcgac caatccgccc ttggcaagct catccatgat ggcaatgatg
     6541 ccaccggcac ggttaacgtc ttgtacatga tacttttggg tattgggagc taccttgcat
     6601 aagcaggggg tcttgcgaga gagcatgtca atgtcgtcca tcttaaaatc cgctccggct
     6661 tcgtgagcca cagccaacaa atgaagtact gtattagtgg aaccgcccat cgcaatatcc
     6721 agcgtcatgg cattcaaaaa tgcctcgcga gtagcaatac tgcgcgggag tacactctca
     6781 tccccttctt cataatatct aaaggcattc gctacaatca acttagctgc atcctcaaac
     6841 agtctcttgc gattttcgtg agtggctaca atcgtgccgt taccgggcag tgccaatcca
     6901 atcgcttcat tcaggcaatt catggaatta gcggtaaaca tgcctgagca gcatccgcaa
     6961 gtggggcagg catgttgctc aatctgtgcc acctctttat cgcccacact ttcatcagca
     7021 gatttaatca tagcatcaat caaatccaaa tgttgtccgt tccattcccc ggcttccatc
     7081 ggaccgcctg aaacaaacac agtcggtata ttcagcctca tagccgccat caacatcccc
     7141 ggagtaatct tgtcacagtt actgatgcaa accatagcat ccgccttatg ggcatttacc
     7201 atatactcca cactatcggc aatgatatct cttgaaggca gggaataaag cataccgtcg
     7261 tgtcccatag cgataccgtc gtcaatggca atcgtattga actccgcagc aaaacacccc
     7321 agcttttcaa tctcttcctt tacaaactgg cctatttcgt gcaggtgtac atgtccgggg
     7381 acgaattgtg taaatgaatt gactatagcg ataatgggct tacccatctg ttccttcttc
     7441 ataccattcg ccgtccacaa tgcacgggct cccgccatgc ggcgaccttg tgtgctgaac
     7501 gagctgcgta actgatgctt cattttcaaa tctcctttta atgaaaaagc ctctcccact
     7561 atagtgagaa aggcttaata aattatcttc taacgtacga atacatacat aacctttctc
     7621 acgctcttga tgccaccacc acgacgcgaa taatatgcag gactgccagg ttaatagatg
     7681 tatgtaaatt cataacttaa ttcttctttt ttgtttcaaa cgtgctgcaa aggtaagggc
     7741 ttttttataa tctccaaaca aattgaagaa aaaaataaga taaatatgaa taatcgtaag
     7801 aaaaaatcgc cctaaaatcc tattttatca cttaacagtt ctaaatagaa ccattcagac
     7861 agccaatgta aatgtattgc caatcattga aaccatttaa taatctgaaa attaccaaag
     7921 gctctctaca tcccgaaaca aataattcgt atctttgtct cttcaaatac tcaaaaaaac
     7981 agtatttact aattaaataa agatagaaaa ttaatggaaa cagtagaaaa caagtacatc
     8041 accgtagcat ataagctgta ctcaatcgaa aacggagaaa aagatttcga agaagaagca
     8101 cccgtagagc atcctttcca gtttatctca ggtctgggaa tgacactcga accttttgaa
     8161 gcccagataa aagacttgca gataggcgat aaattcgact ttaccattcc ggcatcagaa
     8221 gcttatggtg aatatgacga cgaccatgtc attgacctcc ccaaagaaat cttcatgata
     8281 gaaggagaat tcgacagcga ccgtgtagtg gaaggcgctg tcatcccctt gatgacttct
     8341 gaaggtcaac gcatcaatgg aagtgtagta gaagtaaagg aagacgtagt tgtaatggac
     8401 atgaatcatc cactcgcagg ttgtgatttg aactttaccg gagaagtggt ggaaagccgc
     8461 ccggccacga acgaagagct tgctgaagtt gcccgtatga tggnnnnnnn nnntgatggg
     8521 tggcggttgt ggtagctgcg gttgtggtga ctgtggcgac ggatgcggcg accatgaatg
     8581 tggaggcgga tgctgccact aaagaattaa aaattaaaga attaaaaatt aaagaatcag
     8641 actacacagt attaagcatg ccgcatggta attctttaat ttttaattct ttaattttca
     8701 aattctatat tatttacttg tcattatctc caataccaat ttatcagttt cattcattcc
     8761 tttagaaccg atttttgtca gattacggat actttgatcc acatcctcat caataatacc
     8821 ttctacggaa gtcacacaac ggttttccat ggccatgatg gctgaaagca ctgcggttga
     8881 aactccggtg gttactttca atgcacaact gggcttggca ccatcacaaa tcattccggt
     8941 aagattggca atcatgttct gtacagcata tgccacctgt tcataagttc ctcccattag
     9001 ccaagttata ccgcaactgg aacccgtagc agcaaccaca caaccgcata aggcagataa
     9061 gcgtcccaaa ctctgcttga tataaattac cgtcaaatgg ctcaacatca aggcgcgtat
     9121 caattcttcc tccgattttc cgttttcttc ggcataaatc aaaaccggca acgtagcgga
     9181 tataccttga ttaccgcttc ctgaattact catgaccgga atcatagctc ctgccatacg
     9241 ggcatcgcag gcaccggaag tataagaaag aatatgggaa aaaacactat cccccataac
     9301 cttgtgctca taagtaccgc gaaggatttt tcccagacca tgtccgtaat caccctcaaa
     9361 agaacgttct gcagccgcct tattcagacg ggccgtttca aggataaaac ggatgtcgtc
     9421 taatggggtt gtcatggcga agtcatacac tttgcgtaaa gtcaagtcca atacatcctc
     9481 ctcttcgata caagaggcaa tttgtttgtc caataagatg tcaccgttgc gcgttatata
     9541 agtaaagcaa gtatgcccac cggcaataat agctgttgcc ttgtccgtat cagcttcaca
     9601 acatacttct atataaagct tctcttccat atcgtttttt aaagatatat gaatgcgctt
     9661 ttcttctatg aaacgctttc ctgcctccac tgcatcagga gtactttctt tcaaaacctc
     9721 caattgatat gccgacttac ctattaaggc gccaagcgcc acagcaatcg gtaatccaat
     9781 catccccgta cctggaatac ccactcccat tgcatttttc agaatattgg cactcagcaa
     9841 tacagttatc ttttcgggac gcttattcag cacttccgca gcctttgcta cacacaatgc
     9901 cacagctata ggttctgtac aaccaatggc aggaattact tcagatttaa ccaaagcaat
     9961 aatctgtcgt ctttccgttt ctgtcatatc atttctacaa tttgattatt tatcatgcaa
    10021 atgtaggaaa aaacaaacaa aaatccctcc tctataacct gaaaatcagg agacaaagga
    10081 gggaaaattc catatcgaaa aaaaagttat ttagcggcag tcaagttcaa accaacttcc
    10141 aaacgagttg tttcattaat tatttcaggt aaacccttca acataccttc tgccataccg
    10201 gccatacttc caaaatcagg atcagctttc attgcttcga taagcatatt cacaaactcc
    10261 tcatccgaga ataaaggagc aactatattt ttcatcaaag gcaataacaa atccgtattc
    10321 aaataagcct ttaatttacc ttcgttcttt tcgtaagtca aaggcacacc gtcagttacc
    10381 aaaggaagca aagacgtaac agcctgagac aagatttcac tcatatcgat agccttggta
    10441 gaactgccca gacgttttac attggcgatg atagcatcca gattcaaata taccttcatt
    10501 tgggtatcac tgagaaccac atattgtgca acattcgcag gagtcttaac aacagaggta
    10561 cctccctgag cggcatcaac ataagaagca gaaatattac cgtcagcacc caaagtaata
    10621 tcatgcaaca cactacacaa catatcctct acattcactt tatcatcacc acctgcgtca
    10681 attaaaggca tacgaagagc taacgtcaaa attgtttgaa tcggtagctc ccagccaggc
    10741 attacctcta cattcttatt ggattcccaa atcaaatgaa tcggttcttc cgtataatca
    10801 gaattaaggg gtgtaggaac ccaagttgtt ccggataaag cggaattttt caatgcgaca
    10861 ttagttaaat ctaatttcaa ggaagaagca gtaacctttc ctgcatagtc aaaagtacaa
    10921 taatcggtct cacttgtgcc ggaaaacgaa cattcatcac cttgtatatt caaagtaacc
    10981 ggaagggtta caaccggaga accagggaat acgcctgcac caaaagaacc ggaagccgct
    11041 tcacgtgtaa gaataccgga aagatccaaa ttgccagcca ataccaaagt agccttggtt
    11101 gcatcagaag catccggagt aaaagttact ttctttccca acattgatcc accgttataa
    11161 gtcaagttca aacctgttgc aactgtaaac tctgtttgcg gcacaggaca tactaccttg
    11221 tcatcgtcat catcactaca agccgtgaat aaactcattg aacagatcaa tgcaaataaa
    11281 taaaataaat tctttttcat acttttttga gtacttgttt agttaataaa aagcttccca
    11341 agggagctat taatttccca ttttaaatca aaggtgcaaa gtaacacttt ttaaggttac
    11401 agtacaaggt cttttctaaa aaataaatgt tccttttttc atcattacga gtgaaattcg
    11461 gatgcagatt tcataaagag taagccattt ttataaagaa caagccattg accaaactct
    11521 ggcaaaggca ggcaacttta tgcggaaaag actttttatc ttatttcctt aaacgtttta
    11581 tgaaaaaaag ttgttatctt tataaagtca aaagcatttc ttataaagcg tattggcaca
    11641 ttaacctcat atataaacct ttaaagcatt tgatatgttc aactcatttg gaaatattct
    11701 ccgtcttacc agttttgggg aatcgcacgg taagggtgtg ggaggagtga tagacggatt
    11761 ccctgcagga atagtcattg atatggattt cgtccaggca gagctcgacc gacgccgccc
    11821 cggacagtca cgtatcacta ccgcccggaa agaaggtgat aaagtggagt tcctctccgg
    11881 catcttcgaa ggaaaatcca caggctgccc cataggattc attgtatgga accaaaacca
    11941 acattctgac ggttacaata atctgaaaga agtctaccga ccgtcacatg ccgactatac
    12001 ttataaagtg aaatatggca tccgcgacca ccgcggaggt ggacgttcat cagcccgtga
    12061 aacaatctcg cgtgtagtag cgggtgccct ggccaaattg gcgctgaagc agctgggtat
    12121 acacatcacg gcgtacactt cacaagtagg tcctatccgc cttgaagaaa attataccgc
    12181 atacgacctc gacctgatag agaccaatcc ggtccgctgc cccgacccgg cgaaggcaaa
    12241 agaaatggaa gaactcatct tcaagataaa gggagaagga gataccatcg gaggagtggt
    12301 gacttgtgtc gtcaaaggat gccccatcgg actgggacaa cccgtattcg gcaagctcca
    12361 tgcagcactt ggagcagcca tgctcagcat caatgcagca aaagcattcg agtatggaga
    12421 cggtttcaag ggattaaagc agaaaggctc ggagcagaat gatgtgttct acaacaataa
    12481 cggacgtatc gagacccgca ccaatcattc gggcggtata caaggtggaa tcagtaacgg
    12541 gcaagacatc tatttccgtg tagccttcaa acccgtggca accgtactga tggagcaaca
    12601 caccgtgaac attgacggtg tagacaccac cctgaaagcc cgaggacgcc atgacccgtg
    12661 cgtattgcca cgcgcagtac ccatcgtgga agcaatgaca gcaatgacat tgttggatta
    12721 ttacctgatt gacagaacaa cacaactata atattcaccc atggaaataa a
//
