LOCUS       gnlProkkaHIFOIJLJ_37   11057 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HIFOIJLJ_37.
ACCESSION   gnlProkkaHIFOIJLJ_37
VERSION     gnlProkkaHIFOIJLJ_37
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 03:48:27
            Original ID  :: gnl|Prokka|HIFOIJLJ_37
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11057
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11057
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[1:1057]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2..1057
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..11057
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..11057
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(2..1057)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Ranthipeptide_rSAM_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_12"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg37_1"
                     /sec_met_domain="Ranthipeptide_rSAM_RRE (E-value: 5.2e-09,
                     bitscore: 26.1, seeds: 20, tool: rule-based-clusters)"
                     /sec_met_domain="PF04055 (E-value: 1.4e-16, bitscore: 51.1,
                     seeds: 518, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_12 (E-value: 7.8e-11, bitscore: 32.2,
                     seeds: 84, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKLEYKNSPVLGFILNSKYYLYDRYSNSIFTVPRIFFEYLDDLI
                     SLDTDEFTQKYHNIFSKEEIIDLFKTLDYCQNDKKLIKPNRIPKFTISSIYSNAKKVEK
                     KLKKELTFLCINITEECNLRCEYCIFSGKYTKSRRHNSNNQIEWNYIEKGVNLFLEHST
                     DSNIRKIGFYGGEPLLYFDIIRKTINYVRSKCDNAIFTITTNATLLKDKILSFFVENNV
                     EITISLDGPQNIHDKNRIFPNGVGSFNTVIKNIESIKRLHHDFFENNIKFSATLSPGKY
                     KIKDLIDFFTYDMFPTLKRADLPLSLNYINYEENKYLSEVKYLDWTKKTENEIFKLYKK
                     IHIKGINKTSEI"
     CDS             complement(1101..1274)
                     /locus_tag="ctg37_2"
                     /transl_table=11
                     /translation="MKQKTKKISWENFKDEIKVISAGQQKLLTGGGCACCICSPGNGNS
                     GLGGSTKASISH"
     CDS             complement(1295..2329)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR04085"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) SPASM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_3"
                     /sec_met_domain="TIGR04085 (E-value: 1.7e-11, bitscore:
                     34.3, seeds: 281, tool: rule-based-clusters)"
                     /sec_met_domain="SPASM (E-value: 4e-08, bitscore: 23.6,
                     seeds: 166, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLKTAKKAVDFYFKNSNNCNHQISFIGGEPLLKFNLIKKIVEYI
                     KTFNNKVSFTIITNGSLLKEDILNYLIENMFHITISFDGEKEIQGLNRLSKDKKNSFDI
                     VYNNIRKIQLNNTRYFEQYVTINSVYSINITSSLSEFTNYLEAHFKNKFAINIQSSEIN
                     DEYTKFHNNFTKSFLSIYENIHIQGFENSSPPLFIISSDLHKKMMFFSRRSNNILQEET
                     RFIPIKSCLPYLNKIYISPTGDIFMCSDLYYIKGFNIGNIDKSIELNKLQDIMTQYTNF
                     RNKTCKKCWVYRFCDFCFYTLYASKERKGINKYCKIIKYDYAQVIKSYIKILKSNGSAF
                     DIYY"
     CDS             complement(2350..2679)
                     /locus_tag="ctg37_4"
                     /transl_table=11
                     /translation="MEDLFKTYKRNVALGINIDNLYYIHDRSSNNILEVSKYIYENLDY
                     LSLFESSIENIFINKKLSANYFNQWIPKLNTLKQNIDNTLSELTLNITETCNFRCKYCF
                     FNKKK"
     CDS             complement(2691..3533)
                     /locus_tag="ctg37_5"
                     /transl_table=11
                     /translation="MRKQILIICIYIGELPWYFKFFLKSCSFNKDIDFLILCDQDMTSK
                     GISNNIKIKRYDLQDFKKDVHRSLNINTPIQNGYKLCDFKPAYGYIFSRYIEGYDFWGY
                     CDIDVIFGNIRAFITENILSKYEIITVRQDYLSGCFTLFKNEHKTNTLFMQSKNYLKVF
                     LSEKNFCFDETNFAFDEFAKSKDAYNINTEIESMTHVVLKMKDKGLLKPYFNLHILEGL
                     PGNMTWKKGTLLYKNKYEVLLYHLIFFKDFFKQYNKSTVPDEFIIEQTRITEISAFSY"
     CDS             complement(3677..4804)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Glycos_transf_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1045:glycosyl transferase group 1 (Score: 98.1;
                     E-value: 1.1e-29)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_6"
                     /sec_met_domain="Glycos_transf_1 (E-value: 1.8e-19,
                     bitscore: 59.8, seeds: 63, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRFAILSPIYPYRGGIAQFSGMLYTELVKEGHEVKAFNFKRLYPD
                     ILFPGKTQYVEAGDRAIEIESVRVLDSVNPVSYFSTVNAIRSYAPDVLIISYWMSFFVP
                     GYAHVANRMKKHCKVITLIHNAIPHEPRFFDKPLASLLFKQCHGFIVMSDNVRYDLRKL
                     YPGAKYIQNPHPLYNHFGSKINKNEACRKLGIHPSKKNLLFFGLIRDYKGLDLLIEAMG
                     QLNEDYHLIIAGECYGSFEKYQALIDASPAKERIFVHCEYISDEEIPIYFSAADALVLP
                     YRSATQSGVVSVAYNYDLPMLSTPVGDFKNSIEKPGTGIVVPEISATALAQGIEELFTP
                     SQQATIPANISKEKAALSWETLTRKLLDFINSGFI"
     CDS             complement(4907..6325)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) 2-Hacid_dh_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_7"
                     /sec_met_domain="2-Hacid_dh_C (E-value: 3.1e-09, bitscore:
                     26.2, seeds: 135, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSQLFPTNLPYKVADMSLAEFGRKEIEIAEHEMPGLMALRQKYAD
                     QKPLKGARITGSLHMTIQTAVLIETLVALGADVRWASCNIFSTQDHAAAAIAADGVPVF
                     AWKGETLEEYWWCTDMALRFPEGKGPHMIVDDGGDASLLIHMGYRAENDAETINRKGGN
                     HEEQVILDTLNRILQEDNGRWHRTVAEMKGVSEETTTGVHRLYQMMEKGELLVPAINVN
                     DSVTKSKFDNLYGCRESLADGIKRATDVMIAGKVVVVAGYGDVGKGCSHSMRSYGARVL
                     VTEIDPICALQAAMEGFEVTTMEEAVKEGNIFVTTTGNCDIITIEHMTQMKDQAIVCNI
                     GHFDNEIQVDKLVNYPNIKHTNIKPQVDKYTFPNGNSIFLLAEGRLVNLGCATGHPSFV
                     MSNSFTNQVLAQMDLWQMAYEVGVYRLPKRLDEEVARLHLERIGVKLSTLSQKQADYIG
                     VPVEGPYKADHYRY"
     CDS             complement(6511..7266)
                     /NRPS_PKS="Domain: PKS_KR (8-162). E-value: 2.2e-16. Score:
                     52.1. Matches aSDomain: nrpspksdomains_ctg37_8_PKS_KR.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     227; E-value: 4.4e-69)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_8"
                     /sec_met_domain="adh_short (E-value: 3.6e-38, bitscore:
                     121.1, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 6.2e-32, bitscore:
                     101.2, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTKTTEEKVALVTGSAMGIGLACAEAFAKAGYITVLADIREPREQ
                     VEKLVAEGHKAVAYRCDVSNTQAVKEMIDWIVATYGRLDAALNNAGIQTPQRPMAEITD
                     DEFDRTVAVDLKGVWNCMRYEILQMLKQGGGAIVNTSSQGGVTGFPGQAAYIACKHAVI
                     GLTRTAAIDYAAKNIRINAVCPGVIRTPMAEDLMRRDPSLEKELVRDIPAGRLGKPEEI
                     ANAVLWLCSPQASFVDGHALLVDGAFSIH"
     aSDomain        complement(6781..7242)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_8_PKS_KR.1"
                     /evalue="2.20E-16"
                     /label="ctg37_8_PKS_KR.1"
                     /locus_tag="ctg37_8"
                     /protein_end="162"
                     /protein_start="8"
                     /score="52.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VALVTGSAMGIGLACAEAFAKAGYITVLADIREPREQVEKLVAEG
                     HKAVAYRCDVSNTQAVKEMIDWIVATYGRLDAALNNAGIQTPQRPMAEITDDEFDRTVA
                     VDLKGVWNCMRYEILQMLKQGGGAIVNTSSQGGVTGFPGQAAYIACKHAV"
     CDS_motif       complement(6796..6855)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_8_0001"
                     /evalue="2.10E-04"
                     /label="PKSI-KR_m4"
                     /locus_tag="ctg37_8"
                     /protein_end="157"
                     /protein_start="137"
                     /score="13.8"
                     /tool="antismash"
                     /translation="VNTSSQGGVTGFPGQAAYIA"
     CDS             complement(7376..8194)
                     /gene_functions="regulatory (smcogs) SMCOG1287:AraC family
                     transcriptional regulator (Score: 53.5; E-value: 3.3e-16)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg37_9"
                     /transl_table=11
                     /translation="MDGINTLRYSDLFLAMYFDGGKSCLHRNHSHVLVYVYSGEMVIDE
                     KGQITRLHKGECAFIRKDFSVQMTKQAWNGEQFKAIFLMFTMKFLRDFYSKLDRNTLPK
                     DAKRDQVSLYKLPSNRPDIVSLFESMTPYFNSKIQPTDELLQLKMVEGVYVLLNTDKNL
                     YASIFDFTDPWKIDILEFMERNYMNDISMEEIANYTGRSLSTFKRDFKKCSALSPREWL
                     IRRRLEAAHGLIRKGGRKVSEICFEVGFKNLSHFSKIYKIAYGVPPTEDI"
     CDS             complement(8288..9937)
                     /NRPS_PKS="Domain: AMP-binding (11-443). E-value: 1e-97.
                     Score: 319.2. Matches aSDomain:
                     nrpspksdomains_ctg37_10_AMP-binding.1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     380.5; E-value: 1.7e-115)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg37_10"
                     /sec_met_domain="AMP-binding (E-value: 3e-109, bitscore:
                     355.0, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELHNRTLGQWLEHWAENTPDKEYIVYSDRDLRFTWSEFNKRVDD
                     MAKGMLAIGITHGTHVGVWATNVPDWLTFLYAGAKIGAVLVTINTNYKQSELEYLVENA
                     DIHTMCITDGVFDGSYVDMVYTMLPELKTSQRGYLKSERFPRLRNVVYIGQEKYRGMYN
                     TPEMLLLGQNIKDETLEAAKARVNCHDVVNMQYTSGTTGFPKGVMLTHYNIANNGFLTG
                     EHMKFTADDKLCCCVPLFHCFGVVLASMNVLTHGCTQVMVEKFDPLLVLASIHKERCTA
                     VYGVPTMFIAELNHPMFEMFDLTSLRTGIMAGSLCPVELMKTVDEKMHMRVTSVYGLTE
                     TSPGMTHSRIEDPAEVRYNTVGHEFEFTEVRVIDPETGEECPVGVQGEMCNRGYNNMKG
                     YYKNEAATNEAIDKDGFLHSGDLGVRDENGNFRITGRIKDMIIRGGENIYPRELEEFLY
                     HFPGVKDVQVAAVPSKKYGEEVGAFIILHDGVTATEEEVKDFCRGKIARHKIPKYIFFV
                     DTFPMTGSGKIQKFKLKDLGLKLLQEQGITPA"
     aSDomain        complement(8609..9904)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg37_10_AMP-binding.1"
                     /evalue="1.00E-97"
                     /label="ctg37_10_AMP-binding.1"
                     /locus_tag="ctg37_10"
                     /protein_end="443"
                     /protein_start="11"
                     /score="319.2"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="LEHWAENTPDKEYIVYSDRDLRFTWSEFNKRVDDMAKGMLAIGIT
                     HGTHVGVWATNVPDWLTFLYAGAKIGAVLVTINTNYKQSELEYLVENADIHTMCITDGV
                     FDGSYVDMVYTMLPELKTSQRGYLKSERFPRLRNVVYIGQEKYRGMYNTPEMLLLGQNI
                     KDETLEAAKARVNCHDVVNMQYTSGTTGFPKGVMLTHYNIANNGFLTGEHMKFTADDKL
                     CCCVPLFHCFGVVLASMNVLTHGCTQVMVEKFDPLLVLASIHKERCTAVYGVPTMFIAE
                     LNHPMFEMFDLTSLRTGIMAGSLCPVELMKTVDEKMHMRVTSVYGLTETSPGMTHSRIE
                     DPAEVRYNTVGHEFEFTEVRVIDPETGEECPVGVQGEMCNRGYNNMKGYYKNEAATNEA
                     IDKDGFLHSGDLGVRDENGNFRITGRIKDMIIR"
     CDS_motif       complement(8708..8794)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_10_0002"
                     /evalue="1.40E-03"
                     /label="NRPS-A_a6"
                     /locus_tag="ctg37_10"
                     /protein_end="410"
                     /protein_start="381"
                     /score="11.2"
                     /tool="antismash"
                     /translation="PVGVQGEMCNRGYNNMKGYYKNEAATNEA"
     CDS_motif       complement(9305..9355)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg37_10_0001"
                     /evalue="2.10E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg37_10"
                     /protein_end="211"
                     /protein_start="194"
                     /score="23.3"
                     /tool="antismash"
                     /translation="QYTSGTTGFPKGVMLTH"
     CDS             complement(9950..10531)
                     /gene_functions="other (smcogs) SMCOG1148:hypothetical
                     protein (Score: 92.5; E-value: 6.5e-28)"
                     /gene_kind="other"
                     /locus_tag="ctg37_11"
                     /transl_table=11
                     /translation="MGNNKIIGAKIKNIRESKQLSIEEVAERSGLGIEQIERIEGNLDF
                     PSLAPLIKIARVLGVRLGTFLDDQAELGPVVCRKKDSEADGIGFTNNATQGHKHMDYHS
                     LSQDKSGRHMEPFLIEIAPSEEGEDFILSTHEGEEFIYVLNGVVEINYGKNTYILEEGD
                     SIYYDSIVAHHVHAAADNKARILGVVYTPY"
     CDS             complement(10691..10960)
                     /locus_tag="ctg37_12"
                     /transl_table=11
                     /translation="MYLDSAKKKELFEKYGKSATNTGSAESQIALFTFRISHLTEHLKV
                     NHKDYATERSLKMLVGKRRRLLDYLIKTDIERYRAIIKELGIRK"
ORIGIN
        1 gtatttcaga agttttattg attcctttta tatggatttt tttatataac ttaaaaattt
       61 cgttttcagt tttttttgtc caatctaaat attttacttc gcttaaatat ttattttctt
      121 cgtaatttat ataattaaga cttaatggaa ggtctgctct tttcagcgta gggaacatat
      181 cgtatgtaaa aaagtcaatt aaatctttga ttttgtattt cccaggtgat aatgtcgctg
      241 agaattttat attattttca aaaaaatcat gatgtaatcg tttgatagat tctatgtttt
      301 ttatgacggt gttaaaactc ccaacgccat taggaaaaat cctgttttta tcatgaatgt
      361 tttgaggacc atctaggcta atggtgatct ctacattatt ttctacaaag aaagacaaaa
      421 ttttgtcttt tagtaaagtt gcatttgtgg taattgtgaa aattgcgtta tcacatttac
      481 ttcggacata attgatagtt tttcttatta tgtcaaaata tagaagaggt tcgcctccat
      541 agaaacctat ttttctaata ttagagtctg tgctgtgttc taagaataaa ttaacacctt
      601 tttctatata attccactcg atttgattgt tgctgttatg tcttcttgat ttcgtatatt
      661 tcccagagaa tatgcagtac tcgcatctga gattacattc ttcagttata tttatgcata
      721 ggaaggttaa ttcttttttg agtttctttt ctactttttt agcgttagaa tagatggatg
      781 aaatggtgaa tttaggtatt ctattaggtt ttattagttt tttgtcgttt tggcaataat
      841 ctaatgtctt aaatagatct ataatctcct cttttgaaaa aatattatga tatttttgag
      901 tgaattcatc tgtgtcaagg ctaattagat cgtctaaata ctcaaaaaat attcttggaa
      961 ctgtaaaaat ggaattggaa tatctatcgt ataggtaata ttttgaattt aaaatgaaac
     1021 ctagtactgg gctatttttg tattctagtt tttccataaa gtgaaagctt atgcggggag
     1081 agaaatctcc ccgcaggtta ttaatgtgaa attgaagctt tggttgagcc tcctaaaccg
     1141 ctattcccat tacctgggct acagatgcag caagcacatc cacctccggt gagtaacttt
     1201 tgctgtccgg cagagattac tttaatctcg tctttaaagt tttcccatga gattttcttc
     1261 gttttttgtt tcatacgctg aataatttta tatgttagta atatatatca aacgcactcc
     1321 cgtttgattt taatatctta atatatgatt tgatgacttg ggcgtaatca tattttatta
     1381 ttttacaata tttatttatt ccttttcgtt ctttagaagc atataatgta taaaaacaaa
     1441 aatcgcagaa tctataaacc caacattttt tacatgtttt atttctgaag ttagtgtatt
     1501 gtgtcattat atcttgtagc ttgtttaatt ctatagattt atcaatattt ccgatattaa
     1561 atccttttat gtaatataaa tcgctgcaca tgaaaatgtc acctgtcggt gatatatata
     1621 tcttgtttaa gtaaggaagg cagcttttta tgggaataaa tcttgtttct tcttgcagga
     1681 tgttgtttga tcttcttgaa aagaacatca tctttttatg taagtcgctg gaaattataa
     1741 ataaaggggg ggagctattt tcgaatcctt gtatgtgtat attttcatat attgataaaa
     1801 aggattttgt gaaattatta tggaatttcg tgtattcatc gtttatctca gatgattgaa
     1861 tatttatagc aaatttattt ttgaaatgtg cttctagata gttggtgaat tcggaaaggg
     1921 aacttgttat attgattgaa tatacggaat ttattgttac atattgttcg aagtatcttg
     1981 tgttgtttag ttgtattttg cgtatattgt tatatactat atcaaaactg ttttttttat
     2041 cttttgataa tctgttcaat ccttgaattt ctttttctcc atcaaaactt atagttatat
     2101 gaaacatgtt ttcaattaga taatttaata tgtcttcttt taataaagag ccatttgtta
     2161 tgattgtgaa tgatactttg ttgttgaatg tttttatgta ttcaacaatt ttttttatta
     2221 agttgaactt gagtagaggc tctcctccta tgaatgatat ttggtggttg caattattgc
     2281 tgtttttgaa ataaaaatca actgcttttt ttgctgtttt taaggacatt gatttggagt
     2341 atgattcttc tatttttttt tgttaaagaa acaatacttg catctgaagt tgcacgtttc
     2401 tgtaatattt agtgttaatt cagataacgt attatctatg ttttgtttta atgtgttgag
     2461 cttaggaatc cattgattaa agtagtttgc tgaaagtttt ttattaataa aaatattttc
     2521 aatggaactt tcaaaaagtg atagataatc tagattttca tagatatatt tactgacttc
     2581 taaaatgtta ttagaagacc tgtcgtgtat gtaatatagg ttgtctatat taatacctaa
     2641 tgcaacattc cttttgtatg ttttaaatag atcttccata tgaatagatt ttaatagcta
     2701 aatgcggaaa tctcagttat tcttgtttgc tctataatga attcatccgg tacagtactt
     2761 ttgttatatt gtttgaagaa atctttaaag aatattaggt gatataataa aacctcatac
     2821 ttgtttttat ataatagggt tcctttcttc catgtcatat ttccaggtag tccttcaagg
     2881 atatgaaggt tgaagtatgg ctttaataag cctttatctt tcatttttaa tacaacatga
     2941 gtcatgcttt ctatctctgt atttatatta tatgcatctt ttgattttgc aaattcatca
     3001 aaagcaaagt ttgtttcgtc aaagcaaaag tttttttcag atagaaaaac ttttagataa
     3061 tttttgcttt gcataaatag tgtgtttgtt ttatgttcgt tcttgaacaa tgtaaaacac
     3121 ccggataaat aatcttgacg gacagttata atttcatatt tagaaagtat attttctgtt
     3181 ataaatgctc ttatattccc aaaaatgaca tcaatatcac agtatcccca aaaatcatag
     3241 ccttctatat atctagaaaa tatgtaacca tatgccggtt taaaatcaca tagtttgtat
     3301 ccattttgaa ttggagtatt gatgtttaaa gatctatgaa catctttttt aaagtcttgt
     3361 agatcatatc ttttgatttt aatattgtta gagatccctt tactagtcat gtcttgatcg
     3421 caaaggatga gaaagtcaat gtccttgttg aaggaacaag attttaggaa gaatttaaaa
     3481 taccaaggta attctcctat gtagatgcat attatcaata tttgttttct cattcttgta
     3541 tttaacgtga tttcgcaatg taatgatttt agagaaataa gtatgtatgt cttttatttt
     3601 ttttgcgtta aaaaaataaa atgcatctat ctgtgctgtt tgaagagaat gtcaagtgga
     3661 aaatagtcag taagtcctag atgaaaccgc tattgataaa atcgagcagt tttctcgtta
     3721 gggtttccca cgagagggct gctttttctt tggatatgtt cgcagggatg gtggcttgct
     3781 gtgagggggt gaaaagttcc tcgatacctt gggcgagggc cgttgcggat atctcaggca
     3841 ctacgatgcc tgtacccggc ttttcgatgc tgttcttgaa atcgcctacg ggagtactta
     3901 acataggtaa atcgtaattg taggctacgg atacgacacc gctttgagtg gcggagcgat
     3961 aggggagtac caaggcatcc gccgctgaga aataaatggg gatttcctcg tcgctgatat
     4021 attcacagtg gacgaatata cgttcttttg ccggagatgc atcgatcaga gcctgatact
     4081 tctcgaaact accgtaacat tcgccggcta taatgagatg gtaatcctcg ttaagctgtc
     4141 ccatcgcttc tatcagcaga tctaatcctt tataatcccg tatcagtcca aagaatagaa
     4201 gattcttttt ggacggatgg attcctaatt tccggcacgc ctcgttcttg ttgatcttac
     4261 tcccgaaatg attgtaaagc gggtgtgggt tctggatata tttagcgccc gggtaaagtt
     4321 tccgcaaatc ataccgcacg ttatcgctca tcacgataaa gccatggcat tgcttgaaaa
     4381 gtaacgaagc taaaggcttg tcgaagaaac gcggctcatg gggaatcgca ttgtggataa
     4441 gggtgattac cttgcaatgc ttcttcatcc ggttcgctac gtgggcgtat ccgggaacga
     4501 aaaaggacat ccagtaagag ataatcagta cgtccggcgc ataggaacga atggcgttta
     4561 cggtactgaa ataactaacc gggttgacgc tatctaatac tcgcacgctc tcgatttcga
     4621 tcgcacggtc tcccgcttct acgtattgag tcttgccggg aaataagata tccggataaa
     4681 gacgtttgaa gttgaaagcc tttacttcat gaccttcttt tactaattcc gtatagagca
     4741 tcccgctgaa ttgggcgata ccgccacgat agggataaat aggggagaga atagcgaaac
     4801 gcatggtaat tgaaaattaa gaattgaaaa ttgaaaatta agaatcgaga actacaggag
     4861 ctgccctccc ttcattatca attctcaact ttcaatcttc aattaattag tatctgtaat
     4921 gatcagcctt gtacggtcct tctaccggta caccgatata atcagcttgc ttttgtgata
     4981 atgtagataa tttcacgccg atacgttcca agtgtaggcg ggcaacttcc tcatccaagc
     5041 gtttcggtaa gcggtataca cctacctcat aagccatttg ccataagtcc atctgggcaa
     5101 gcacttggtt cgtgaacgag ttactcatta cgaatgacgg gtgtcccgta gcgcaaccta
     5161 agtttaccaa gcgtccctct gccaataaga agatggagtt tccgttcggg aacgtatatt
     5221 tgtccacttg aggtttgata ttcgtgtgct tgatattcgg atagttgaca agcttgtcca
     5281 cttggatctc gttgtcgaag tgaccgatgt tacatacgat cgcttgatct ttcatctgtg
     5341 tcatatgctc gatcgtgatg atatcgcagt ttccggtggt tgtaacgaag atgttaccct
     5401 ctttcacggc ctcttccatg gtcgtaacct cgaaaccttc catagcggct tgcagggcgc
     5461 agatcggatc gatctcggtc acgagtacgc gagccccgta agagcgcatg gagtgagagc
     5521 agcctttacc tacgtcaccg tatccggcca cgactactac cttgccggcg atcatcacgt
     5581 ctgtagcccg tttgatgccg tccgccaaag actcacggca accgtataag ttatcgaact
     5641 tggatttcgt cacggagtca ttaacattga tagccggaac cagcaactca cctttctcca
     5701 tcatctgata cagacggtga acgccggtgg tcgtctcttc cgacacacct ttcatctcgg
     5761 ctaccgtacg gtgccaacgg ccgttatctt cttgaaggat gcgatttaat gtatccagga
     5821 ttacctgttc ctcatgattc ccgcctttgc ggttgatggt ctccgcgtcg ttctccgcac
     5881 gatagcccat gtgaatcagc aaggaagcgt cgccgccatc gtcaacaatc atgtgagggc
     5941 ctttaccttc cggaaaacga agcgccatgt ccgtacacca ccaatattct tccagcgtct
     6001 cgcctttcca agcgaatacc ggtacgccgt ccgccgcgat agcggctgcc gcatggtcct
     6061 gtgtggagaa gatgttacag ctagcccagc gaacgtccgc tcccaacgca actaatgttt
     6121 cgattaacac cgccgtctga atagtcatat gcagtgagcc ggtgatacgt gcgcctttca
     6181 agggtttctg atcggcgtat ttctggcgta gcgccattaa tcccggcatt tcgtgttcgg
     6241 cgatctcgat ctctttgcga ccgaattcag ccaaactcat atctgccact ttataaggca
     6301 gattagttgg aaataattgt gacataaatt aatactataa atggttgaga cgcgaaggta
     6361 cgaaaaagcg ttgatagtag gtgttcttta tctatgaatt tccatctagg gcagaggctt
     6421 gccgaggggt aggtgggttc gttactgcaa cctgccttgc agtagttctg caacagccat
     6481 gcagtattgg gctctctgta gttttgcgct ttaatgaata ctgaaggctc catctaccaa
     6541 tagcgcgtgg ccatcgacga agctcgcttg cgggctgcat agccaaagta cggcgttggc
     6601 gatctcttcc ggtttaccga gccgccctgc gggaatgtcg cgcaccagct ccttctccaa
     6661 ggaagggtca cgccgcatta agtcttccgc catcggcgta cggataacgc ccggacatac
     6721 ggcattgatg cggatgttct ttgccgcata gtcgatagcg gcggtacgtg tcagtccgat
     6781 aacggcatgc ttacaggcta tgtaggccgc ttgccccgga aatcccgtga ctccgccttg
     6841 cgatgaggtg ttgacgatgg ctccgccgcc ttgtttcagc atttgcagga tctcataacg
     6901 catgcagttc cagacacctt tcaaatccac agccacggta cggtcgaatt catcgtcggt
     6961 gatttctgcc attgggcgtt gcggtgtttg tatgcctgcg ttgttaagag ccgcgtccag
     7021 tcttccgtag gtagctacga tccagtcgat catctccttt acggcttgcg tgtttgatac
     7081 gtcgcaccga tacgctacgg ccttatgtcc ctcggctact aatttctcta cctgttctct
     7141 cggctcacgg atgtctgcca atacggttat gtatccagcc ttggcgaagg cttcggcgca
     7201 agcgagtccg atacccatcg cagaaccggt tactaaagct actttctctt ccgttgtctt
     7261 tgtcatgatc atttgattta cattttgtta ttatttatgt cgcgaagata aggagggagt
     7321 ggtatagagg ctttgttatg tggttcaaat agctttgttg tgtgggccat taatattata
     7381 tatcctcggt tggcggtacg ccatacgcta tcttatagat tttcgagaaa tgggaaaggt
     7441 tcttgaagcc tacttcgaaa caaatctccg agaccttacg ccccccttta cgtatcagcc
     7501 cgtgtgcggc ttcaaggcgg cgtcggatga gccattcccg gggcgagaga gcgctacatt
     7561 tcttgaaatc acgtttaaat gtggagagac tgcgtcccgt atagttggcg atttcttcca
     7621 tggaaatatc gttcatgtaa ttccgctcca tgaattccag tatgtctatc ttccatggat
     7681 cggtaaaatc gaagatagag gcatatagat tcttgtcggt attgagcaac acataaacgc
     7741 cctcgaccat ttttagttgc agcaattcgt ctgtcggttg gatcttggaa ttgaaataag
     7801 gggtcatcga ctcaaacaag cttacgatat cgggacggtt ggacggtagc ttgtaaaggc
     7861 ttacctgatc tcgcttggca tctttaggga gagtatttcg atctaatttg ctgtaaaagt
     7921 cgcgtaggaa cttcatggtg aacatcaaga agatcgcctt gaactgctcg ccattccatg
     7981 cttgtttcgt catctgcaca ctgaagtcct tgcggatgaa agcgcattct cctttatgta
     8041 accgggtgat ttggcctttc tcgtcgatta ccatctctcc ggaatataca tacaccaaca
     8101 catgcgaatg attccggtgc aggcagctct tcccgccatc gaaatacatc gctaaaaata
     8161 aatccgagta acgcagcgtg ttgattccgt ccatagttct ttaggaaaat gggcaacacg
     8221 agaagatcgt accgcccatt atgaagattt taaagtaact gtcaactgtt agctgtccac
     8281 taaatcgtca ggccggcgtg ataccttgct cttgcaatag tttcagcccg aggtctttca
     8341 acttgaactt ctgtatcttt ccgcttccgg tcatcgggaa ggtatcgacg aagaagatgt
     8401 atttcgggat cttatgccgg gcgatctttc cgcggcagaa atctttcacc tcttcctccg
     8461 tagccgtcac accatcgtga aggatgataa aggcacccac ttcctctcca tatttcttgg
     8521 aaggaacagc ggctacttgc acgtctttca cgccggggaa atgataaagg aattcctcca
     8581 gctcacgtgg atagatattc tcgcctccac ggataatcat atccttgata cggccggtga
     8641 tacggaagtt tccattctca tcacgaacgc ccaagtcgcc ggaatgcagg aaaccatcct
     8701 tgtcgatcgc ctcattggtg gcggcttcgt ttttatagta acctttcatg ttattataac
     8761 cgcggttaca catctcgccc tgtacgccga cggggcattc ctcgccagtc tccggatcga
     8821 taacccgtac ctcggtaaat tcgaactcat ggcctacagt attataacgc acctcggccg
     8881 gatcttcgat acgggagtgg gtcatacccg gtgaggtctc tgtcaatcca tacacgctgg
     8941 ttacacgcat atgcatcttc tcgtccacgg ttttcatgag ttcaaccggg caaagagaac
     9001 ctgccataat accggtacgt aacgacgtga ggtcgaacat ctcgaacatc gggtggttca
     9061 gctcggcaat gaacatggta ggcacgccgt acacggccgt gcaacgctct ttatgtatag
     9121 aagctaatac caatagcgga tcgaatttct cgaccatcac ttgcgtacat ccatgcgtca
     9181 atacgttcat ggaagctaat accacgccaa agcaatgaaa gagaggtacg cagcaacaaa
     9241 gcttatcgtc ggcggtgaat ttcatatgct cacccgtcaa gaaaccgttg ttggcgatgt
     9301 tgtagtgagt caacatgacc cctttcggga agccggtcgt accggaagta tattgcatat
     9361 tgacaacgtc gtggcaattt actctcgctt tggcagcctc taaggtctca tccttgatat
     9421 tttgtccgag gagcaacatc tcgggcgtat tgtacatacc cctgtatttc tcctgtccga
     9481 tatatactac atttctcaag cgtgggaaac gctcgctttt caaatacccc cgttgagagg
     9541 tcttcaattc cggcaacatg gtatagacca tgtccacgta acttccatca aacacgccgt
     9601 ctgtgataca catcgtatgg atatcggcgt tctctactag gtattccagc tcgctttgtt
     9661 tatagttcgt attgatcgtg accaatacgg caccgatctt cgcgcctgca tataggaatg
     9721 tcaaccaatc cggtacgttc gtcgcccata cgccgacatg tgtgccatgg gtgataccga
     9781 tcgccaacat acctttcgcc atgtcgtcca cacgcttgtt gaattcgctc caagtgaaac
     9841 gtaagtcacg gtctgaataa acgatatact ccttatccgg tgtattctcg gcccaatgtt
     9901 ccagccattg gccaagggtt ctgttatgta attccataaa acgccggatt taataaggtg
     9961 tatagacaac tcctaggatt cgggccttgt tgtcggctgc cgcatgtaca tgatgcgcca
    10021 cgatagaatc ataatagatg ctatcgcctt cctctaggat ataggtgttc tttccgtaat
    10081 tgatctctac gacgccattc aatacgtaga taaactcctc tccctcatgc gtggacagga
    10141 tgaaatcctc gccttcctcg gagggagcga tctcgatcaa gaagggttcc atatggcggc
    10201 cggacttatc ttgtgagagc gagtggtaat ccatatgctt gtgtccttgt gtcgcgttgt
    10261 tcgtgaaccc gataccatcg gcctcgctgt cctttttgcg gcatacgact gggcctagct
    10321 ccgcttgatc atccaagaat gtacccaaac gtacccctaa tacccgtgct attttgataa
    10381 gaggggccaa agatggaaaa tccaagttac cctcgatacg ttctatctgt tcgataccta
    10441 acccggagcg ttcggctacc tcctcgatag agagttgttt cgattcccgg atatttttaa
    10501 ttttcgcgcc tataattttg ttgtttccca tgtgtatgat ttgttattta tagtcctgta
    10561 atgtttgata atttgatact aaacggcgca aatttacatt aatattttat tatatctagg
    10621 attaagacaa ataaaaaggg caatacccat ttgggattgc cctttttaat attttcgagt
    10681 aagctttttc ttactttctg ataccaagtt ctttgatgat agcgcggtat ctctcgatgt
    10741 cagtcttgat cagatagtcc aataaacgac gacgtttacc taccaacatc ttcaatgatc
    10801 tttccgtagc gtaatctttg tgattcactt tcaagtgctc tgtcaagtga gagatacgga
    10861 atgtgaacaa tgcgatttgg ctctcagcag aacctgtgtt agttgctgat ttgccatact
    10921 tttcaaataa ttcttttttc ttcgctgaat ctaaatacat gattcttttt actttaataa
    10981 attaatacta tgttatctaa gcggtcgcaa aggtagacat tcctttttga tttgcaatag
    11041 attctactat ctttttt
//
