LOCUS       c00357_gnlPro..         3723 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HJGAEPOL_357.
ACCESSION   c00357_gnlPro..
VERSION     c00357_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 08:22:04
            Original ID  :: gnl|Prokka|HJGAEPOL_357
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 3723
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..1599
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg357_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.4e-51, bitscore:
                     161.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="YDSLYDYRDQLRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGP
                     GATNTITGIADALMDSTPMVVIAGQVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPE
                     EIAWAVSRAFYIASTGRPGPVVLDLAKDAQVGLVEYEYKKVDYVRSYQPEPDINKDRIK
                     AAADLINEAKKPFCLVGQGVLLGGAEEELKAFLQKNDIPAGSTVLGLSALPTDFPLNKG
                     MLGMHGNVGPNRKTNECDVLIAIGMRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVA
                     VDVKVLGNAKHTIPMITALLEERRRLEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGE
                     VVRKVSEATGNDAVLVTDVGQNQMMGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKF
                     GAPDRTVCFFTGDGGMQMTIQELGTIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYS
                     NTIMENPDFVAIAKAYGIAGRAVEKREELDDAIAEMLNHDGAYVLVANVETCGMVYPMV
                     PAGGSVTNMIMGDEK"
     protocluster    1..3723
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:3723]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..3723
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..3723
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..3723
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             1615..2169
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg357_2"
                     /sec_met_domain="ALS_ss_C (E-value: 4.9e-18, bitscore:
                     53.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNETCVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             2176..2901
                     /locus_tag="ctg357_3"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             2959..3723
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg357_4"
                     /sec_met_domain="IlvN (E-value: 2.8e-48, bitscore: 151.7,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 9.4e-19, bitscore: 56.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQSLN
                     LRDNGFNVIVGQRQGKTYDKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMSVWP
                     TMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGRGLN
                     SSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGLLLA
                     QYEVLRENGHTPSEAFNETVEELTQSLMPLFAD"
ORIGIN
        1 tacgacagtt tatatgatta tagggaccag ttgaggcatg tattggtgcg ccacgagcaa
       61 ggcgctaccc atgcggctca aggatatgcc cgtgtatccg gcaaggtagg agtgacgttg
      121 gttacttccg gcccgggcgc tacgaatacc atcacgggta tcgctgatgc gctgatggat
      181 agtacgccaa tggtcgtaat cgccggtcaa gtaccctcgc cgttgttggg aaccgatgct
      241 tttcaggaag tcgacgtgat tggcatcacg caaccgatca cgaaatgggc ttatcaaatc
      301 cgtaagccgg aggagatcgc atgggctgtt tctcgtgctt tttatatcgc ttctacaggc
      361 cgtccgggtc cagttgtgct ggatttagcg aaggacgcgc aagtagggtt ggtggaatat
      421 gaatataaga aggtcgatta cgtacgtagt tatcaaccgg agccggatat caataaggat
      481 cgtatcaagg ccgccgccga tttaatcaat gaggcgaaga aacccttctg tctggtcgga
      541 cagggagtat tgttaggcgg tgcggaagag gaattgaaag cgtttctcca aaagaatgat
      601 atacctgccg gatctacggt attgggctta tctgcgttgc caaccgattt cccattgaac
      661 aagggaatgc tcggcatgca tggaaacgta gggccgaacc ggaaaacgaa tgagtgtgat
      721 gtattgatcg ctatcggtat gcgtttcgac gaccgtgtga ctggcgattt aaagacatac
      781 gctaagcaag ccaagattat ccatctggat atcgataact cggaaatagg caagaatgtt
      841 gccgtggatg taaaggtgct gggtaatgcc aagcacacga taccgatgat cacggcgttg
      901 ttggaagaac gtagacgtct ggaatggaat gccgagttcg atcgggacga gaaagaggaa
      961 tacgataagg taatcgagaa ggaattgtat ccgaccgagg gccaactgaa aatgggcgag
     1021 gtagtccgta aggtttccga ggcgaccggt aacgacgctg tattggtaac cgacgttggg
     1081 cagaaccaga tgatgggcgt ccgctatttc aaatataaac aaacccgtag cgtggtgact
     1141 tccggtggtt taggtacgat gggatttggt ctgccggccg ctatgggcgc taagttcgga
     1201 gctccggacc gtacggtctg cttctttacc ggtgatgggg gtatgcagat gacgattcag
     1261 gaattgggca ctatcatgca ggagaaactg aacgtgaaga ttatcattct taataataac
     1321 ttcttaggta tggtacgtca gtggcaagaa ttgttcttcc acgagcgtta ttcaaacacc
     1381 atcatggaga atccggattt cgtggcgatc gctaaagcct atggtatcgc cggccgtgcc
     1441 gttgaaaagc gggaggaatt ggacgacgct atcgctgaga tgctaaacca cgacggcgct
     1501 tacgtgttgg tcgctaacgt ggagacttgc ggaatggtat atccgatggt tcctgccggg
     1561 ggaagcgtga caaacatgat tatgggagac gagaaataag gaggagatga agctatgaca
     1621 acaaagaaat tatataccgt tattatcttt tcagagaata tcgtaggtct tttgaaccag
     1681 ataacgatta tctttacacg ccgacagctg aacatcgaga ctctgtccgt ctctccgtcc
     1741 gctatcaagg gtatccataa gtttacgatc acgacattcg ccgatgagga tatgatcgat
     1801 aaggtggtga aacagatcga taaacgtgtg gatatcttga aggcttatta taatacggat
     1861 gaggatttgg tttatcaaga gatcgctctt tataagctaa gtaccgagct tttcatcaag
     1921 atgggaaccg tggagggatt gatccgtaaa tacaacgctc gtatcttgga gatgaacgag
     1981 acctgcgtgg tattggagaa gagtggccac tatgacgaga cacaagcctt gttcaatgag
     2041 ttgagcgaga cgatcggtgt cctgcaattc atccgctccg gacgtgtggc tatcacgaag
     2101 agcaaggtgg agcgcttgag cgatatgttg gccgatatgg agcgaaagtt acatgaaaag
     2161 caacaataat aagatatgga gaaagtagga ttatttcatt tcgtggcgga gccgtatttg
     2221 atggatttca ggggacgtgt aacgctccct atgattggta actatttgat tcacgccgct
     2281 tccagccatg ccggagagcg tgggttcggt ttcaatgata tgtcggagcg tcatacggct
     2341 tgggtgttgt cccgtctggc tatcgagatg aaggaatatc ctaccgcctt cgataagatt
     2401 aatctataca cttggatcga tgaggtcgga cgcctcttca ccagtcgttg tttcgagctg
     2461 gcggatgaga atgggaaaac ctttggattc gcccgttcta tttgggcggc tatcgacgtg
     2521 gagacccgcc gtcctacctt attggatata gaggcattgg gcaaatatat cgacgagcgt
     2581 ccgtgcccga tcgagaagcc gggcaagatc atgccggcgg agaataaggc ggagggaatc
     2641 ccgtattcga tcaaatacag cgacttggat atcaacggtc acttcaatag cgtgaagtat
     2701 atcgagcatc tgctggattt gttcgatatc gaccagttca agacccgtga gatcggccgt
     2761 ctggagatcg cctaccaatc cgagggtaaa caaggtatgc cgcttacgct tcataaggcg
     2821 gagtccgctc ccgataagca agacatggct atttgccatg agggaaaggc gatctgtcgt
     2881 gcggcggtta cttggagata ataagagaga tacataaata ggtttttaaa cattaatagt
     2941 taaaaaaaaa tggcacaaat gaattttggc ggtgttgtag agaatgtaat gacccgcgag
     3001 gaatttccgt tggaaaaggc aagagagata ttaaaagatg agacaatcgc tgttatcggc
     3061 tatggcgtac agggaccggg acagtcattg aaccttcgtg acaatggctt caacgtaatc
     3121 gttggccagc gccaaggtaa gacttacgat aaagcggttg aggacggatg ggttccgggt
     3181 gagactctgt tcggtatcga ggaggcttgc gacaaggcca cgatcatcat gtgcttgttg
     3241 tccgacgctg ccgtaatgtc tgtatggcct acgatgaagc cttatttgac agctggcaag
     3301 gccctgtatt tctctcatgg tttcgcgatc acttggaacg atcgtacggg cgttgttcct
     3361 cccgcggata ttgacgtgat catggtcgct ccgaaggggt ctggtacgtc tttgcgttcc
     3421 atgttccttg agggtcgtgg cttgaactct tctttcgcta tctatcaaga cgctactggc
     3481 aaggcgatgg atcgtacgtt ggcgttgggt atcggtatcg gttccggcta cttgttcgag
     3541 acgactttca tccgtgaggc tacttccgat ttgactggtg agcgtggttc cttgatgggc
     3601 gctatccaag gtttgttgtt ggcccagtat gaggtattgc gcgagaatgg acatactcct
     3661 tccgaggctt tcaacgagac ggtcgaggag cttacgcaga gcctcatgcc gctgttcgcc
     3721 gac
//
