LOCUS       c00012_gnlPro..        14946 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PCAOJOHL_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 08:26:21
            Original ID  :: gnl|Prokka|PCAOJOHL_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14946
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14946
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[88:4946]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      89..4946
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14946
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14946
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             89..1321
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_1"
                     /sec_met_domain="HBT (E-value: 8.6e-17, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLPNNMEGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
     CDS             1318..2415
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_2"
                     /sec_met_domain="Chorismate_bind (E-value: 7.6e-54,
                     bitscore: 174.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTNPLLKGSQDKLVLSRSKTIWKDPSFSPGKAFFAAEERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             2430..4118
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4.4e-07, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDPFEFLEKIAYMLEN
                     RQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             4122..4946
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="ECH_1 (E-value: 1.6e-81, bitscore: 265.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             4983..6041
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_5"
                     /sec_met_domain="MR_MLE_C (E-value: 9.6e-30, bitscore:
                     95.7, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERLYRIEVVPRCLTFKRPAGTSRGVYTTRKLWEVRIRKEDEP
                     SVIGIGECAPLPDLSCDYGVDYEITLSKACLDLEQKGYVDTESLRHYPSILFGLETAMR
                     HYEQGGWRHYDTPFSQGQAGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRAHFSAKEIELRVDANGAFTPSEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMARLAAESPLPIALDEELIGCNAPDEKRRLLETIHPQYIILKPSLHGGIAGCTEWVHL
                     AETILGSTPEQPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHKLIQ
                     RKGDTIWFTNDL"
     CDS             6045..7043
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 53.3; E-value:
                     5.7e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_6"
                     /sec_met_domain="AMP-binding (E-value: 5.6e-17, bitscore:
                     53.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVCEPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHVALRRLNGPEASPYYHPFPSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDRPYAITATPDPRLGEAVVLLLASNLR
                     GEMLTEVLANLPKYLRPRHIIKVSEIPQTGSGKIDRAACRELARNIITKTL"
     CDS             7046..9007
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MKRILTITAVSLLALSPMYGQDSCRYPQDPTLEKSQAYAGYDCVT
                     LLDSTAVTVQPTGSGAFAVCKAFKVQTSKGAVANRIIKYDYDPLTAHAEFRYATIYRAN
                     GDVINLDVTQACDYAAPARAIYWGARQIMLEVGRLQPGDIVEYEIAKKGFTYALLTAGD
                     DDERFIPPMRGQFYDIVPFWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDRR
                     KVYTFASDDILPFAKEPNMVDLFDAAPKLMMSSTPRWEDKSLWFNKVNEDYGSFTAIPE
                     AQKKVDELIKGKKTEMEKIAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVC
                     KDIAGTLIAFLRMAGFEAYPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWV
                     PFCRELWSSAEQQQNYLPGVPEGSDLRLTPVSAPENHYVRIHADNRLDEKGTLRGQFTI
                     TAEGQSDSNIRRIFTTGWQSDWQNTMEKQLLAVSPNAKLLRVDYGKDPKNYQAAPIKIT
                     FSYEIPDYAIIAGDQMLIKPLVMNNLYNQVKSFLRIDTKPENRAYGFKDACSRLVEQDE
                     TIRLPKGYTLLNAPKNDVLQSNAADFEGSLSQEGNQNIVLRQKLALKKRVYDAADWKGF
                     RSAVNAYKSYGDYLIIKK"
     CDS             9021..10619
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MIKITYKLILLLGLLAMTVTSFAASEAEYGKVSKAWTLHADGSQE
                     YRSSMELTLFTHTAMNSTYGESFIVYNPDFQTLKIHSSYTRQKDGTIVKTPDNAFVEVL
                     PRFAADAPAYNQLKEMVVVHTGLELGATIYLDYSIITKPGYYPAMDINERLQETSPVKE
                     CKVSISVPENSPLAWQLLGSDAKASQATRNGAKEVSWTLRNLPASSREAFLPQNQDGIP
                     RLIASSYSSNKEALSTLNKRFNTSGNYESKTFGSYITEKATSDEEKVNAIRNHVVNNMG
                     YCAIPLACTGYSIRDVDTALRSAYGTLAEKTQLLNVLLNAAGIQSEVVAVYPGNLDIDA
                     CGLSTIKNLAVKATVAGKDKYLSAVSLAPSALTARGELDQVLTLNGTSIALQAEPTIIK
                     ENKAVSVSKNEAQNGFAICTLPAITGGIDSWGMSALNSKRSNLFELPSLIKEEVTYTVT
                     PAEGMKLQTSTKEQVISKPFGKVTRTITPRGNTIEVVRTIELDKQQFTPAEYSDVRSLI
                     HEWTNPDNRVLLFSL"
     CDS             10767..13280
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="MKTLKYLLATMLLLCVCNLTHSQKLSLGIFPEPQEVTISSQTYAP
                     PHGYTLRGINNPDADAVKLLKEALPFAKSGKSLPLEIKKLKDKTPEMQRSGAYTLTITK
                     KGITIGIVDDNSLFYAAQTLKQLAKYDEGKKILPLCSIKDYPDVLFRGTVEGFYGQPWS
                     HADRIEQIRFYGRIKLNTYIYGPKDDPYHSSPNWRKPYPAEEAEHIKELAKEAAHNKVN
                     FVWAIHPGQDIQWNLTDSMNILSKFEKMYDLGVRSFAVFFDDISGEGARPEKQAGLLNY
                     IHKEFITKKNDVQPLIMCPTEYNRSWAKTDYLDILGTQLDPAIQIMWTGDRVVADITKE
                     GVEWVNSRIRRPAYIWWNFPVSDYCQDHLLMGPAYGLDTQAAGTMTGFVSNPMEYAEAS
                     KVAIFGVGMYTWNIKNYDPTQAWKDACDFIMPEASMAFRIFCEHNCDPGPNGHQYRREE
                     SANYVAPIQTFLTGYKKNTFPEQSANLLGTLFAQITASPSMIYSQSPNKRLIEQINPWL
                     IQFEFLGKAGTSALHMAHAWYEKDRSYTWQRYLETSALLDSMKLINRTLNQKAQPKGVK
                     VGSKVLHPFIVDLYRQTGRNLLSTDGIAPDEVKVSIPSIFTNIDQLKSQPCAEGDNTVG
                     YVPLFEVVKVQPNQYLGIGWEIQKEAESFCFNLPKSNQPGRVFEWSADGKSWSLIPHVS
                     TENAKDTIRTIDPKARYIRMRNNSDQQMELYVLGFTATTKQDPQINEALMMYDMNLDTY
                     KNLNPGEIIHIKCDDINAVSFFLSGSNENLVSITGLSQDGEKNIVYQGNVGYIKLNKTM
                     FEDFSSLEITTIGKEPIHIHQIVRE"
     CDS             13422..14087
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MRKIETEKTMRKEERYKGVLNWFKENVPVAETELHYDDPYQLLIA
                     VILSAQCTDKRVNMITPALFEAFPTPEVMAASTPEVVFEYIRSVSYPNNKAKHLVGMAK
                     MLIEDFKGVVPSDIDELQKLPGVGRKTANVIASVVYDKPAMAVDTHVFRVSNRIGLTNN
                     SKTPLETEKELVKNIPEELIPIAHHWLILHGRYVCLARKPKCEECGLKPWCKHFLKQT"
ORIGIN
        1 agtcgtttag cgtcatttct cccgtttttc gaggttattc cagagattta tagtatattt
       61 gtattctaaa ccataaaaat aagacgccat gaagtacaaa ttattagtct tagacgtaga
      121 tgggacgttg cttaacgaca agaaagagat aactccccgg acccatgccg ccttgttaaa
      181 ggctcagcag atgggagttc atgttgtatt ggcatccggc cgacccacca acggggttca
      241 acccttggcg gaggctcttg aattgaatca ttacggtggt ttcatattat cttataacgg
      301 aggtcagatc atcaatgccc agaccggaga attgatgttc gagaaacgaa tcgatccggc
      361 catgattcct tatttaaacc ggaaggcgaa ggaaaatggt tttgctatct tcacgtatca
      421 caaggactat atcctgaccg atagcccgga aaacaagcat gtccaagagg aggccgaact
      481 caataagatg cgcatcatcg gtgtggagaa tttcccggaa gcggtggatt tcgcaccctg
      541 taagtgtatt cttaccagcg atgacgagaa caatctagtg ggtctcgaaa atcattggaa
      601 gaaacgtttg gacggggtat tggaagcttt ccgctccgag gactatttct tggaggtagc
      661 tcctcatttc atcaataagg gaaatacgtt ggcggtattg atggagatgc tgaatatcac
      721 gaccgaagag gttgtcgcta tcggtgatgg cgtggccgac gtatccatgc ttcaattagc
      781 cggtaccggc gtggcgatgg gtaacgcacg cgattccgta aaggcttgtg ccgatttcac
      841 gaccttaccc aataatatgg aaggtgtggc ggtagcgatc gagaaagcga tccttgccac
      901 gatcaaaccc acagaggttc cgttagatca actaaacgca cgggccaaac atgctttaat
      961 gggtaatcta ggcattcaat atacctatgc gtcagaggat cgtgtggaag cgaccatgcc
     1021 tgtagacgaa cggacccgcc agcctttcgg tatcttgcac ggaggcgcta cgctggcttt
     1081 ggcggagacc gtggccggac taggttccat gattctggcg aaaccggacg agatggtagt
     1141 cggcatgcaa gttagcggca gccatatgtc gtccgcccac gagggagaca cggtacgtgc
     1201 cgtcgggacg attatccaca aaggccgttc atcccatgtg tggaacgtag acatattcac
     1261 ctctaccgac aaactggttt cctctgtacg ggtaatcaat agtatactaa agaagaaatg
     1321 attccaagag attcttacga aataatagac acgttgatca agcaaggccg gagtttcgct
     1381 atttggcgta ttcccggtga ggataggctc catttcagga tgcaaagcgc cggctctcct
     1441 tgcctattat acgacataaa agacttaaat gaacggagcg gttttgtaat cgctccgttt
     1501 caggtgacag cggaacgacc tatcgtttta atccaaccgg attgctttga aatcccctcc
     1561 gaatccgatt gggatttctc tcgagagaaa aacgaattcc cttcgaatga aatcgaaatc
     1621 ccgtccgaat ccgaggagaa ggaacgatac gcttaccatt tctccctgtt taccaaccct
     1681 ttgctaaaag gaagccaaga taaactagtc ctatcccgta gcaaaacgat ctggaaagat
     1741 ccctctttct cacccggcaa ggcattcttc gccgcggaag aacgatatat ccgctcctat
     1801 gtctaccttt gccatacccc ggaaaccgga acttggatgg gtgggacacc ggaaatcttg
     1861 ttatccggcg agaaaggtga ctggcaaacg gtagctttgg ccggaaccca atccttacga
     1921 gacgggaaat taccgaaaag ctgggaccat aagaattgga gagaacagca attagtcgcc
     1981 tcctatatac gccgccagct gtccaccttg ggtattactc ccgaggagaa ggggccttat
     2041 tcagcccggg ccggagaggt ttctcatttg aaaagtgatt tcttcttctc cttgccgaat
     2101 cccgagaagc tgggtgatgt ccttcaacta ttacacccta ctccagccgt ctgcggtctt
     2161 cccaaggagg aggcttatca tttcatcatc gaaaatgagg ggtacgatcg tagctattac
     2221 tccggtttca tcggttggct ggatcccaaa ggcaaaacag atctgtacgt aaacctccgt
     2281 tgcatgaata tcctccccca aacctttacg ctgtatgccg gaggcggtct gttggcggcc
     2341 tcgcagctag aggatgagtg gcaggagaca gaggataaat tagatacaat gcggagaata
     2401 gtgggtaatt tataatttta tatcatataa tgtatagcga taaaaagaac atccttcaat
     2461 tggtagcctt gctgatagag cacggcgtaa gtaatatcgt gctatgtccg ggaagccgga
     2521 actctccgat tgtgcacaca ttggcaaacc attcgttctt caattgccat tccgtgacgg
     2581 atgaacgaag cgcgggattc tttgccgtag ggctagcgtt gcacggaggt aagccggcgg
     2641 ctgtttgctg tacctcgggc acggccttgc tgaatataca tccggcggta gcggaggctt
     2701 tctatcagaa agttccgctt gtcgtgatat ccgccgaccg ccccgccgca tggatcgggc
     2761 aaatggacgg acagaccttg ccgcaacccg gggtgttcgg ctcgctggta aagaagtcgg
     2821 tgcagctacc ggaaatacat acggatcaag atgaatggta ttgcaatcga ttgatcaacg
     2881 aggcgttgtt ggaactgaac catcacggca aaggaccggt gcatatcaac gttccgatct
     2941 ccgagccttt atttcagttc acgacacccg aattgccgaa ggtacgggta atcacccgtt
     3001 atcaaggctt gaacgtgtac gaccggaaat atgatgacct gatcgagcgc ttgaacaaat
     3061 atagcaagcg gatgatgata gcgggacaaa tgagcttgat ctatctcttc gagaagaaaa
     3121 tatgcaagtt actatacaag catttcactt ggctctccga gcacatcggc aaccgtatcg
     3181 taccgggatt accgatcaag aatttcgacg ctatcctgta cgctaccccg gaggaggaaa
     3241 aagagaagct agttcccgag ctcgtaatca cctacggcgg ccatattgtc tccaagcggc
     3301 tgaaagagtt tttgcggaaa cacccgccta aggagcattg gcatgtctca ttggatggag
     3361 aggtagcgga tttattcggt agcctgacca cggtgatcga gatggaccct ttcgagtttc
     3421 tggagaaaat cgcttatatg ctggagaata ggcagattga atatccgaag gcttgggaat
     3481 acaaatcccg gaacctgccg gagccggagt tcgcttactc cgaaatggcg gcgatcggtg
     3541 gtttgatacg ctcgcttccg gctgaatcgg ccttgcatct ggggaatagc tccaccgtac
     3601 gttacgcgca attgtacacc gtacccgaga cggttgaggt ttgttgtaac cgaggtacga
     3661 gcgggatcga aggctccttg tctacggcca tcggatacgc ctcggcctcg caaaaactaa
     3721 actttatcgt tataggcgat cttagtttct tctatgatat gaatgcgttg tggaacggta
     3781 acttgcacaa taaccttcgc atcctgctct tgaacaacgg aggtggcgag atcttccaag
     3841 ccttgccggg attcaagatg aacgagcgta cgcaccgtta cgttaccgcc tcccaccaga
     3901 cctcagcgga gggatgggcc acggaaaggg gattctccta ctccgctgtc cataatgccg
     3961 aggagttggc agcggcgatg agcgccttta cccaaacgga gcaaccgagc gaacatcccc
     4021 tattcatgga ggttttcacg gacaaagcgg aagacgtacg attgctcaag gaatattatc
     4081 atcaactaaa aaattcatcc caagcacaaa acatataata tatggaaacg aaaagagaat
     4141 ggacaaccat caaggaatat gaggagatct tatttgattt ctacaacggc atcgcccgca
     4201 ttacgatcaa ccgggaacgg tatcgcaacg cttttacccc gactacgacc acggagatga
     4261 gcgacgcctt ttacatctgc cgggaacgcc cggacattaa cgtagtcgtt ctgacaggag
     4321 ccggagatac ggccttttgc gcgggaggcg atatgaacgt gaaaggacgt ggcggctacg
     4381 tgggtaaaga cggcgtacct cgcttgaacg tattggacgt acaaaagcag atccgctctc
     4441 tcccgaaacc cgtcatcgcg gccgtgaatg gtttcgctat cggcggcgga cacgtattgc
     4501 acgtggtttg cgaccttacg atcgcttccg agaacgctat cttcggacag actggtcctc
     4561 gtgtgggtag cttcgacgcc gggttcggct cttcttacct cgcccgtgtg gtcggacaga
     4621 aaaaggcccg tgagatctgg ttcctatgcc gcaagtacaa tgcgcaggag gctttggata
     4681 tgggtctggt aaataaggta gtccccttgg ataaattaga ggacgagtac gttcaatggg
     4741 ccgaggagat gatgttgctt agcccgttgg ctttgcgcat gatcaaggcg ggcttaaacg
     4801 ccgagttgga cggacaggcc ggtatacagg agttggccgg agacgctacc atgctttact
     4861 atatgacgga cgaggcgcag gaaggcggta aggcattctt ggagaaacgc cgtccccgct
     4921 tcgaggatta cccgaaattc ccgtaggggg attgagaatg aataatgaat aattaagaat
     4981 gaatggtaaa ggagaggtta tataggattg aggtggttcc ccggtgcttg actttcaagc
     5041 gaccggcagg aacctcacgg ggtgtttaca cgacccggaa attgtgggag gtccgaatcc
     5101 gtaaggaaga cgaaccctcg gttattggta tcggagaatg tgcccccctg ccggatctca
     5161 gttgcgatta tggagtggat tacgagatca cgttatccaa ggcttgcctc gatctggaac
     5221 agaagggata tgttgacacc gaatctttgc gccattaccc atccatcctt ttcgggctgg
     5281 agacggccat gcgccattat gaacagggcg gttggcggca ttacgacacg cccttctcgc
     5341 aggggcaggc gggcatcccc atcaacggac tgatctggat gggcgattat aagtacatgc
     5401 tggaacaggt agaggaaaag atgaaggagg gcttccgctg cgtcaagctg aagatcggcg
     5461 ctatcgattt cgaccgggaa ctctctttat tgaaacacat ccgtgcgcat ttctctgcca
     5521 aggaaataga gcttcgggta gatgccaacg gcgctttcac accctcggag gcgatggaca
     5581 aactgaagcg gctcgccgag atggacttgc attccatcga gcagcctatc cgtgccgggc
     5641 agttggaaga gatggcacgc cttgcggcag agtcacccct tcccatcgct ctcgacgagg
     5701 aactgatcgg ctgtaacgcc ccggacgaga aacggcggtt gttggaaacg atccatcccc
     5761 aatacattat attaaagcct tccctccacg gaggtatcgc cggatgcacg gaatgggttc
     5821 acttagcgga aactatctta gggagtaccc ctgaacaacc taaatggtgg gtcacctccg
     5881 ctctggaatc gcaaatcgga ctgaacgcta tcgcccaatg gtgcgccacg ctaggtaacc
     5941 cgctaccgca aggtctggga accggcgaga ttttcaagga cgataaacat aagttgatcc
     6001 aacgaaaagg agacaccatc tggttcacca acgacctttg acctatgccg atacaagaag
     6061 atttacaggc attcttagct gaatggcacg atccctcccc ttttctggaa gtccagacct
     6121 ctggctccac cggtacgccc aagcggatgc gagtacgcaa ggaccggatg ctgaacagcg
     6181 cccggcttac ctgcgattat ctggggctta agaagggcga caaggccttg ttatgtatgc
     6241 ccctacgcta tatagccgga aagatgatgg tggtccgctc cctatacgcc ggactggatc
     6301 tggaggtgtg cgaaccctcc ggacacccgt tggcggattg gggggatacg cccctgcgct
     6361 ttgccgccat gattcctttg caggtttaca atacgttgcg agtacccgag gaacgtaaac
     6421 ggctggagca aacggatatc ttgatcatcg gcggcggggc gatcgacgcg gccttggaac
     6481 aggagatacg gcagatgcca aacacggttt attccaccta cggaatgacg gagacgctgt
     6541 ctcacgtcgc cctgcgccgg ttgaacgggc cggaagcctc gccctattac catcccttcc
     6601 cctcggtgac gttatccttg tcaccggaca ataccttggt aatagacgcc ccattggttt
     6661 gcgacgagcg gctggtgacg aacgatgtcg cccgcctgct gccggacggg agtttcgcca
     6721 ttatcggaag gaaagataat atcatcaata gcggaggtat caagatccag atcgaggagg
     6781 tggaagagcg gctacggccc tacctcgacc gcccctatgc catcaccgcc acccccgacc
     6841 ctcggttggg agaggcggtc gtgctactgc ttgcctcaaa cctacgaggt gagatgctaa
     6901 cagaggttct cgccaacctg cccaagtacc tccgtccgag gcacatcata aaggtaagcg
     6961 agatccccca aaccggaagc ggcaagatcg accgtgccgc ctgccgggag ctagcgagaa
     7021 atatcattac aaaaacacta taaacatgaa aagaattcta acaatcactg cggtctccct
     7081 attggcctta tcgcctatgt acgggcagga ttcttgccga tacccgcaag atcctacctt
     7141 ggagaaatcg caagcctatg caggatacga ctgcgtcacc ttgctggata gcaccgccgt
     7201 tacggtacaa cctaccggct cgggggcttt cgccgtatgc aaggctttta aggtacagac
     7261 ttccaaagga gccgtcgcca accgtatcat caaatacgat tacgacccgc tgacggcgca
     7321 cgccgagttt cgttacgcca cgatctaccg tgcgaacggc gacgtgatca atctcgacgt
     7381 aacccaagct tgcgactacg ccgcccccgc acgtgccatc tactggggcg cccggcagat
     7441 catgctggaa gtgggccgct tgcaaccggg agatatcgtg gagtacgaga tcgccaagaa
     7501 aggtttcacc tacgccttgc tgacggcggg tgacgacgac gagcgtttca tccctcctat
     7561 gcgaggacag ttttacgata tcgtcccctt ctgggctacc gagcctaccg tgcgcaaggt
     7621 gtaccgggta tccatgccga tggagaaaga gttgcaattc cagttctacc aaggcgaatg
     7681 tacctcttcg atgcgatacg aggacagacg gaaagtatat accttcgcct ccgacgatat
     7741 ccttcctttc gccaaggaac cgaacatggt agacctattc gacgctgccc cgaagctcat
     7801 gatgtccagt actccccgct gggaggataa atccctttgg ttcaataagg ttaacgagga
     7861 ttacggaagc tttactgcga tcccggaagc ccagaaaaag gtagacgagc tgatcaaagg
     7921 caagaaaacg gaaatggaga agatagccgt gctgacccac tgggtggccg ataacatccg
     7981 ttactccgga atctcgatgg gtaaaggcga gggtttcacg cttcacaacc tgaaaatgaa
     8041 ttataccgat cgttgcggtg tctgcaagga tatcgccggt acgttgatcg ccttcctccg
     8101 catggccggc ttcgaggctt acccggcgat gaccatggcg ggaagccgtg tagaaagcat
     8161 ccccgccgac catttcaacc attgcgtggc ggtggtaaaa ctggctagcg gcacgtatat
     8221 gcctctcgac ccgacttggg ttcctttctg ccgggaatta tggagtagcg ccgagcaaca
     8281 gcagaactac ctcccgggtg tgcccgaagg ctccgacctc cgcttaaccc ctgtctccgc
     8341 cccggagaac cactacgtcc gcatccacgc cgacaaccgc ctagacgaga aaggcacgct
     8401 ccgcggacaa ttcacgatca ccgccgaggg acaatccgac agcaatatcc gccgcatctt
     8461 caccaccgga tggcaatccg actggcagaa cacgatggag aagcaattgc tggccgtatc
     8521 ccccaacgcc aaactgcttc gtgtagatta cggtaaggac ccgaagaact atcaagcggc
     8581 ccctatcaag atcacgttct cttatgagat ccccgattac gcgatcatcg ccggagacca
     8641 gatgcttatc aagccgctag tcatgaataa cctctacaat caagtgaaga gtttcttgcg
     8701 tatcgatacg aaaccggaaa accgtgcgta tggattcaag gatgcttgct cccgtttggt
     8761 agaacaagat gagaccatcc gcctccccaa gggctatacc ctcttgaacg ccccgaagaa
     8821 tgacgtcctg caaagcaatg cggccgattt cgaaggttcc ctttcgcagg aaggcaatca
     8881 gaacatcgtc ttgcgccaga agctagcgtt gaagaagcgt gtctacgacg cagccgactg
     8941 gaaaggtttc cgttccgccg tgaacgctta taagagttat ggtgactatt tgattatcaa
     9001 gaaataaaaa cagaaagaca atgattaaga taacctataa actgattctt ctcctaggct
     9061 tgttagcgat gacggttact tcattcgccg catcggaggc tgagtacggg aaggtatcga
     9121 aagcttggac cttgcatgcc gacggtagcc aagaataccg atcctccatg gaattgacgc
     9181 tcttcacgca cactgcgatg aatagcacgt atggcgagag ttttatcgtc tacaatcccg
     9241 atttccaaac actgaagatc cactcatcct atacaaggca gaaagacggt acgatcgtaa
     9301 agacacccga taacgccttt gtagaggtcc taccccgttt cgccgccgac gctccggcct
     9361 ataaccaact caaggaaatg gtcgtggtac acactggcct agaacttggg gccacgattt
     9421 acttggatta ctctattatc acaaaaccgg gctactatcc ggctatggat atcaacgagc
     9481 gactacaaga gacttctccc gtgaaggaat gcaaggtctc tatctccgta ccggaaaaca
     9541 gtccgctcgc ttggcaatta ttgggtagcg acgcgaaagc atcccaagcc acccgaaacg
     9601 gcgctaaaga ggtaagctgg actttacgta acctgccggc ctcttcccgg gaagctttcc
     9661 ttcctcaaaa ccaagacggg attccccgcc taatcgcttc aagctatagt tccaacaagg
     9721 aggcattatc tacgctaaat aagcgtttta acacttccgg aaactacgag agcaaaacgt
     9781 tcggctctta tatcacggaa aaggctacta gcgacgaaga gaaggtgaac gccatccgga
     9841 accatgtagt caacaacatg ggatattgcg ccatccccct cgcttgtacg ggttattcca
     9901 tccgcgatgt cgatacggcc cttcgcagtg cttacggtac attagccgag aagacccagc
     9961 ttctgaacgt cttattgaac gccgccggca ttcaatcgga agtagtcgcc gtatatccag
    10021 ggaatctgga tatagacgct tgtggattaa gcacgatcaa gaatcttgcc gtaaaagcga
    10081 ctgtcgcagg gaaagacaaa tacctttcgg cggtcagcct tgccccttcc gcattaacag
    10141 cccggggtga gttagatcag gtactcacgt tgaacggcac gtcgatcgcc ctacaggcag
    10201 agcctacgat catcaaggag aataaagccg tcagcgtctc caagaacgaa gcacaaaacg
    10261 gattcgccat ctgtaccctt ccggctataa caggcggtat cgatagctgg ggcatgagcg
    10321 ctttgaacag caagcgttcc aacttattcg aactcccctc cctgatcaag gaagaggtaa
    10381 cctacacggt tactcccgcc gagggcatga agttgcagac ctccacaaaa gagcaagtga
    10441 taagcaagcc ttttggtaaa gtaacccgca cgatcacacc aagaggaaat acgatcgagg
    10501 tagtacgtac gatcgagttg gacaagcaac agttcactcc cgccgaatat agcgacgtgc
    10561 gtagcttgat ccatgaatgg acaaatccgg ataaccgggt attgctattc tccctataag
    10621 atctaaaaca cggagcacac ggaacacacg aatatccacg gatataagga aatatcattt
    10681 ctatccatgg aaatctgtgt attccgtgtg ctctgtgtct aattatttca tacatttacg
    10741 aacgttaaca ttaaatcata tcgtatatga agacactaaa gtatttactc gccaccatgc
    10801 tccttctatg cgtttgtaac ctaacgcata gccaaaagct atccctagga atcttccctg
    10861 agccccaaga ggtgactatt tccagccaaa catacgcacc gccccatgga tataccctac
    10921 ggggtataaa taatcccgac gcagatgcgg tcaaactact taaagaagcg ctacctttcg
    10981 ctaaatccgg caaatctctc cctttagaga tcaagaaact aaaagacaaa actccggaaa
    11041 tgcaacgctc gggtgcctat acgctgacga tcactaaaaa aggtatcacg atcgggatcg
    11101 tagacgataa ttccttgttt tacgccgccc aaaccctcaa gcaattagct aaatatgacg
    11161 agggtaaaaa gatcctgcct ctctgttcga tcaaagacta tccggacgta ttattccggg
    11221 gtaccgtgga aggattctac ggacagcctt ggagccacgc cgaccgtatc gagcaaatcc
    11281 gcttttacgg aaggatcaag ctgaacacct atatttatgg tccgaaagat gatccttatc
    11341 acagctcccc caactggcgc aaaccttatc ccgccgagga agccgagcat atcaaggaac
    11401 tagcgaaaga ggccgcccat aacaaagtaa acttcgtttg ggccatccac ccgggacaag
    11461 acattcaatg gaacctaaca gatagcatga atatcctttc caaattcgag aaaatgtacg
    11521 atttgggcgt acgctctttc gccgttttct tcgatgatat atccggagag ggagcccgcc
    11581 cggaaaagca agccggctta ttgaattaca tccataagga gtttattacc aagaaaaatg
    11641 acgtgcagcc cctgatcatg tgccctaccg aatacaaccg ctcatgggct aagaccgatt
    11701 atctagatat cctcggtacc caactcgacc ccgctatcca aatcatgtgg accggagacc
    11761 gtgtcgtagc cgatatcacg aaagaaggcg tcgagtgggt aaacagccgt atccgtcgtc
    11821 ccgcctatat ctggtggaac ttccccgtaa gcgattattg ccaagatcat ttgttgatgg
    11881 gacccgccta cggcctagat acgcaagccg ccggcaccat gaccggattc gtatccaatc
    11941 ctatggaata cgccgaggct tccaaggtcg ctatattcgg cgttggaatg tacacttgga
    12001 atatcaagaa ttacgatcct acacaggcat ggaaagacgc ttgcgacttt attatgccgg
    12061 aggcctccat ggctttccgc attttctgcg agcataactg cgatccgggt ccgaacggac
    12121 atcaataccg ccgggaagag tctgctaact atgtcgctcc tatccagaca ttccttaccg
    12181 gatataagaa aaacacgttc ccagagcaaa gcgcaaatct tctgggaacc ttattcgctc
    12241 aaatcacggc ttccccgagc atgatctaca gccaaagtcc caataaacgc ctgatcgaac
    12301 aaatcaatcc atggcttatc caattcgagt tcttaggaaa agccggtaca agtgctctgc
    12361 atatggcgca cgcttggtat gagaaagacc ggtcttatac atggcaacgc tatctggaaa
    12421 catctgcctt gctagatagc atgaaactga taaaccgcac gctgaaccag aaggcacagc
    12481 ctaaaggcgt gaaagtcgga tcgaaagtct tacacccttt catcgtagac ttatatcgtc
    12541 agacaggtcg taacctgcta tctacggacg gtatcgcccc ggacgaggtg aaggttagca
    12601 tcccttccat attcacgaat atcgaccaat tgaagagcca gccttgtgcc gagggtgata
    12661 atacggtcgg ttacgtcccc ctattcgagg tagtcaaggt acagcctaat caatatctgg
    12721 gtatcggctg ggaaatccag aaagaagcgg aatccttctg tttcaatctt ccgaaaagca
    12781 accaacccgg acgggtattc gagtggtctg ctgacggaaa gagctggagc ctaatccccc
    12841 atgtctccac ggaaaacgcc aaggatacga tccgcaccat cgatccgaaa gcccgttata
    12901 tccgtatgcg aaataactcg gatcagcaaa tggagctata tgtactagga ttcacggcga
    12961 caaccaaaca agacccgcaa atcaatgagg ctcttatgat gtacgatatg aacctagata
    13021 cgtataagaa cttgaatccg ggagaaataa ttcacataaa atgcgatgat atcaacgccg
    13081 tatctttctt cctctccgga agtaacgaga atttggtatc tatcaccggc ctctctcaag
    13141 atggtgagaa aaacatcgtc tatcaaggga acgtaggcta catcaaatta aataaaacca
    13201 tgttcgagga tttctcttct ttagaaatca ccacaatagg aaaagaacct atacatatcc
    13261 accagatcgt tagggaataa taaataaaaa agtaccgatt tctttctctc ttagatggaa
    13321 gaaggagatc ggtacttttt tatttattcg tacaattcgg gagtatctta tttttggcac
    13381 atctccgctt gtatattcct tttaaaagtt atacctttag gatgcgaaaa atagaaaccg
    13441 aaaaaacaat gcgaaaagaa gaaagatata aaggcgtatt aaactggttt aaggaaaacg
    13501 taccggtagc cgagactgaa ctacattatg acgatccata tcaattattg atagcggtaa
    13561 tcctatccgc acaatgcacg gataagcgag tgaatatgat cactcctgcc ctgttcgagg
    13621 ctttccctac tcccgaggta atggcagcta gcacaccgga agtcgtcttt gaatacatac
    13681 gaagcgtatc ttacccgaac aataaggcta aacatctggt aggtatggcg aagatgctga
    13741 tagaggactt caaaggcgtg gttccctccg atattgacga gctacagaaa cttccgggtg
    13801 taggaagaaa aactgcgaac gtaatcgcat ccgttgtata tgacaagcca gccatggcgg
    13861 tagatacgca cgtattccgt gtctccaacc ggatcggctt gaccaataat agcaagacac
    13921 ccttggaaac ggaaaaggag ctagtgaaga acattccgga agaactgatc cccatcgccc
    13981 atcactggtt gatattgcat ggaagatatg tttgcctcgc ccggaaaccg aaatgtgagg
    14041 aatgcggatt aaagccttgg tgtaaacact tcctaaagca aacatgagga tcagcaagaa
    14101 agacataacg gcattttttg tcttgtttct gggtacgatc gtatgcgtga ggtactttta
    14161 caagcatatg aacgacgagc aatttgtcgc tacggtagat ccctatagtt tggtcgttcc
    14221 aagccccacg gcaatttttg ccatcaatcg tcctcctgta ttcgagaaga tgatactacc
    14281 catggagaat atacgcaagg cgttctcaga tcatacgccc gctattttcc tttctttaat
    14341 acggcaaaat ctggaattat cgtctttcct aatcgcttat tatccacaag gggatgtctt
    14401 gtacgcccct atggatagtc atacggcaga gcgtattttc aagcaactgg acgtctcttt
    14461 cacttttccg gcccagcaac gagaggaaac ctccgttcct gttagatatt atcctgatgt
    14521 tgataagcat tttctaggtt gttactacca cgagggtata ttcgtagcgt cctacaaccg
    14581 aagattattg gtagagacgg tggaaaggca acagacatac cccgcacatg tcattccgga
    14641 actaacagat ctgattcgta aaaaaggcaa gcgtggcgca atgaatctct tcatcaaaag
    14701 cgccccttta catttacggg tacaaatgaa tgactcgacg gagtggagaa tgaaaaatca
    14761 atggttggca atggatttat tctataatga aggaagcctt tgctgcttca acgagcaacc
    14821 ctatgagaaa gccttggaga acttttaccc caatttatgc gatacgataa ccacccggat
    14881 caatcggcta ttcccgcaaa taaaaaccac gacacaagtc agtcatgacg aggccgtggc
    14941 atattt
//
