LOCUS       c00045_gnlPro..        13526 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OKAMCPFK_45.
ACCESSION   c00045_gnlPro..
VERSION     c00045_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 09:30:46
            Original ID  :: gnl|Prokka|OKAMCPFK_45
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13526
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13526
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3526]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3526
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13526
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13526
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..1103
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 5.3e-51, bitscore:
                     163.7, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="ASLINNAKKPFCLVGQGVILGGAEEELKEFLLKNDIPAGSTVLGL
                     SALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIGMRFDDRVTGDLKTYAKQAKIIHL
                     DIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERKRPEWNAEFEPDEKEEYNKVIEKE
                     LYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQMMGVRYFKYKQTRSVVTSGGLGTM
                     GFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELGTIMQENLNVKIIVLNNNFLGMVR
                     QWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVDKREDLDEAIAEMLNHDGAYMLVA
                     NVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             1116..1670
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_2"
                     /sec_met_domain="ALS_ss_C (E-value: 4.3e-18, bitscore:
                     56.7, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             1707..2438
                     /locus_tag="ctg45_3"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLTDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSLD
                     KYNMAICNDGKAISRAAVTWI"
     CDS             2489..3526
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_4"
                     /sec_met_domain="IlvN (E-value: 4.5e-48, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1e-43, bitscore: 140.4,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQSLN
                     LRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQIEVW
                     PRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQGRGL
                     NSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQGLLL
                     AQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWMGPF
                     HDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVVRKL
                     RPENN"
     CDS             4028..7306
                     /locus_tag="ctg45_5"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGTITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWI
                     DNLSLRGSYGTTGNDKLIVRESNGKAGDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDL
                     KWESNQQWNIGLDFSVFNRLSGTVEYYSRTSHDLLYYKELPLSAQVGSASGYNMNIGDL
                     RNSGIEITLNANILTTKDFRWDIDANMSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSL
                     YEFIAPQYDGVNPETGVPGWLIRDGNGGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITN
                     NFQFKGIDLSFMFYYSYGSKISDYTYKERIMNRPGVGVIQELVEDRWRQPGDADVLIPR
                     WSYNQYGATVKYADNFVFDNHYWRLRNLTLGYTLPKSLTRKALVENLRVYVTGNNLLTF
                     GPAKKRYTDPETGIMGNSYNGNAETDNGIQGSRRLYMVGIQITL"
     CDS             7325..8914
                     /locus_tag="ctg45_6"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYAIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHSQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKWAFDKYKHYGEDGGSVIQSATRPEVCLMRGAEMLLIMAEAAA
                     QKGNSGEALNLLNRLQVARNATPTTNAGGEALLEDIYVERRKELICEGQAGFYDLVRLQ
                     KRLVRIGESTTNPAGHYVWGMQYLNGYNALDPQPIGTLESNDYRFFCQIPQMEILNNDA
                     ISESDQNPWSGQ"
     CDS             10549..11712
                     /locus_tag="ctg45_7"
                     /transl_table=11
                     /translation="MNKISLLFILSVLITFSAYAQDDIKITHAPYLQNLGENEVTVVWT
                     ANKPSIGWVELAPDDGTHYYQTERPKFFNAKNGIKLTSTVHSVHLTGLKPGTRYRYRVY
                     SQEVLSHVGWRVIYGNVAATSVYGKQPLTFLTSDHGRQSVNFAMVNDIHGKSDVLEKLV
                     SHCDLKKTDMFLFNGDMVSIFNNEKEIFEGFMDKATELFASEIPMYYTRGNHETRGSFA
                     TAFQDYFSPKQEHIYYMFRQGSVCFVILDSGEDKPDSDLEYAGITVYDQYRTEQAEWLK
                     KVLESKEYKEAPFKVVVCHMPPFGGWHGEQEVAEKFIPLLNNAGVDLMLCGHLHRYMRN
                     EPKDGVRFPVIVNSNNTVLKAEAGVKELNIRILDMEGKEVDKLTITK"
ORIGIN
        1 ctgcttcatt gataaataat gccaaaaagc cattctgtct ggtagggcag ggggttatcc
       61 tgggaggagc tgaagaagaa ctgaaagaat tcttgttgaa aaacgatata ccagccggtt
      121 ctaccgtatt gggcttgtct gcattacctt cggacttccc attaaataaa ggtatgttgg
      181 ggatgcatgg aaatgtcgga ccgaaccgca agacaaacga atgtgacgtg ctgattgcta
      241 tcggtatgcg tttcgatgat cgcgtaaccg gcgacctgaa gacttatgcc aagcaggcaa
      301 agattatcca cctggatatc gacaattcgg agatcggaaa gaatgtgccg gtcgacgtga
      361 aagtgctggg aaatgccaag catacgattc cgatgattac ggctttactg gaagaacgga
      421 agcgtccgga atggaatgct gaattcgaac cggatgaaaa agaggaatat aataaggtaa
      481 tagaaaaaga actctatcct accgaaggcc aactgaaaat gggcgaagta gtccgtaagg
      541 tttccgaagc aaccgataat gatgcgattc tggttacgga tgtaggtcag aaccagatga
      601 tgggtgttcg ctatttcaaa tataaacaaa cacgcagcgt agttacttca ggaggtttgg
      661 gaacgatggg ctttggcctt cccgccgcca ttggagcgaa gctgggagcg cctgaccgta
      721 cggtctgttt ctttaccggc gacggtggta tccagatgac tatccaggag ttgggaacta
      781 tcatgcagga aaatctgaat gtaaagatca tcgttcttaa caacaatttc ctgggaatgg
      841 tacgccagtg gcaggagctg ttcttcaacg aacggtattc gaataccatc atgaagaatc
      901 cggattttgt agcgatagcc aaggcttttg gtattgcttc ccgtgcggta gataaacggg
      961 aagacttgga tgaggcgatt gctgaaatgt tgaatcacga tggtgcctat atgttggttg
     1021 ccaatgtgga aacttgtggt atggtatatc cgatggttcc ggccggagga agcgtgacaa
     1081 acatgatttt gggtgataag taaggaggag aaactatgaa tacaaaacaa ttatataccg
     1141 ttattatctt ttcggaaaac actgttggtc ttctgaatca gataactgtt atctttacgc
     1201 gccggcaact gaacattgag acgctttctg tttctccctc tgctataaag ggaatacata
     1261 agtttacaat tactaccttt gccgacgagg atacgatcga caaggtcgta aaacagatcg
     1321 acaagcgtgt ggatatcctg aaagcctatt ataatacgga tgaagacctg gtttaccagg
     1381 aaatcgctct ttataaactg agtaccgaac tctttatcaa gatggggacg gttgaggatc
     1441 tgatccgtaa gtacaatgcc cgtatccttg aaatgaatga ggattgtgtg gtgttggaaa
     1501 agagtggtca ttatgatgag acacaggctt tgtttaaaga attgagtgag acgatcggtg
     1561 tcctgcaatt tatccgttcc ggacgcgttg ctataacgaa gagtaaggta gaacgtctga
     1621 gcgacatgtt atctgcaatg gaaaagaagt tgcaggaaaa acatgtctga gaataataag
     1681 gaaacatttt gtaaataaag taaattatgg agaagaacaa agtaggagaa tttcatttcg
     1741 taacagagtc ttatctgacg gacttccggg gacgtattac aatccctatg atcggaactt
     1801 atttgttgca tgctgcttct tgccatgccg ccgaccgtgg attcggatat aacgatatga
     1861 ccgaaaggca taccgcctgg gttctttccc gtctggctat cgagatgact tcttatcctg
     1921 ccatgtctga atccgtaact ttatatacct gggtggatga ggtcggtaag ttgtttacca
     1981 gccgttgctt tgaactggtg aacggcgaag gcaagacctt tggctttgcc cgctctatct
     2041 gggcggctat cgatatggaa acccgccgcc cgaccttgct cgatgtggag ggcctgagtg
     2101 cttatatcac cgaccgtccc tgtccgattg aaaaaccggg taaaattgct ccggtggaaa
     2161 acaacacttc cggcgaacct taccgtgtga agtatagtga cctggacgta aacggccacc
     2221 tgaacagtat caaatacatg gaacacctgc tcgacttgtt cgatatcagt ctgttccgag
     2281 aaaaagagat aagccgtttc gaaatagctt atcagtccga aggaaagtat gggatggagc
     2341 tgactctcca taaccaggaa gtatccctcg ataaatataa tatggcaatc tgtaacgacg
     2401 gcaaagccat cagccgcgct gccgttacct ggatctgaaa aacaaattat tttatataca
     2461 ttttaatagt aaaaagaaaa tggcagtaat gaattttggc ggcgttgacg aaaacgtagt
     2521 aacccgcgaa gaatttccgt tggaaaaggc aagagaagta ttgaaagacg aaacaatcgc
     2581 tgtaataggt tacggcgtac aaggtcctgg ccagagcctg aacctgcgcg acaacggttt
     2641 taacgtaatt gtaggacaac gtaaaggtgg taagacctgg gaaaaggccg ttgctgacgg
     2701 ttgggtaccg ggcgaaacac tgttcgatat cgaagaagca tgcgaaaaag caactatcat
     2761 ccagtatctg ctttcagatg ctgctcagat tgaagtttgg ccgcgcatca aaaaatacct
     2821 gactccgggt aaggctttgt atttctctca cggattcggt atcacttaca aagaacgtac
     2881 aaacatcatc cctcctgctg atgtagacgt aatcctggtt gctccgaaag gttcaggtac
     2941 ttcactgcgc cgtatgttct tgcagggtcg tggtctgaac tcaagctacg caatcttcca
     3001 ggatgcaaca ggcaaagcat gggatcgcgt gattgcactg ggtatcggtg ttggttctgg
     3061 ttacttgttt gaaacaacat tcaagaaaga agtttattct gacctgaccg gcgaacgtgg
     3121 tactttgatg ggagctatcc agggattact gttggctcag tacgaaactt tgcgtgaaaa
     3181 cggtcacgaa ccttctgaag cattcaatga aacagtagaa gaactgactc agtcattgat
     3241 gccgttgttc gcagaaaacg gtatggactg gatgtatgca aactgttcaa caactgcaca
     3301 gcgtggtgct ttggactgga tgggcccgtt ccacgatgct acaaaaccgg tgttccagaa
     3361 gttgtatagc gaagttgcct gcggtaacga agcacagcgt tctatcgaca caaacagcaa
     3421 gcctgactat cgtgaaggtc tggaaaaaga actggctgct cttcgcgaaa gtgaaatgtg
     3481 gcgtgcaggt gctgttgttc gtaaacttcg tcctgaaaac aactaataaa tggtgataca
     3541 ttaatagtta aacattttgt gatataaaaa cggcaatccg gcttttcggg ttgccgtttt
     3601 tttatggttt atgtaatgcg ttaatggtta aaaaatgttt ttgattgcaa ctgttattga
     3661 tttttcatcc caatatgtat gtcattgttt gaatgtggat tttagataaa aaaatcaatt
     3721 aaatggtggt taaaatatat ttattagagc aataaatata cataattatg cttgtattaa
     3781 ataatgataa gttatatttg ctgatggaga tactgtagtt tgtagagtgg aaatatagaa
     3841 ggatgttgtg tgtaatgatc agtatatctt tgttttagtt aactttattt tattgaaatg
     3901 tatgccagtc acttttatct tagaaaagtg taacctctaa tgaaatgaac gctattgtga
     3961 ttaattttat ttaattaaag acttgaattt agctatgtgg accaactcaa aactaattag
     4021 atcactaatg atttctgtat tattaggtgc ggcaggtgcg attgctgcca atcctacagg
     4081 tccggaaacg atggtagtac aacagggtaa taaggtaacc ggcctggtag aggaccagat
     4141 gggacctgtc gccggagctt ctgttgtagt gaaaggaacc actatcggta cgataaccga
     4201 tatcgatgga aagtttacgc tggataatgt tcggcgggga gcggttattg ttatttcctt
     4261 tgtcggcctg gccactcagg agatcacttg gaacggacaa tctattttaa atgtaaaatt
     4321 aagtgatgcg acacaggacc tggatgaagt cgttgtcgta gcctatggaa cggctaagaa
     4381 atcaaccttc accggatcgg cctccgttgt aaaagctgaa aaactcgaaa agatcatggg
     4441 ctccggcttt gcggaagcat tgcaggggat gagtgccggt gtgaatgttg tgaatgtaca
     4501 gggtaacccc ggagctgatg cccgtgtgga gatccgtggt attgcttcca tgtccggaaa
     4561 ggccgatccg ttatatattg tggacgggat gccttacgat ggaaaactga atcagatcaa
     4621 tcctacggac atagaatcga tgacggtgct gaaggatgcg gcggccactt cgctctacgg
     4681 ttcgcgtgca gcaaacggcg tcgtaatgat tacaaccaag cggggtaaat cagaaaaacc
     4741 gcgtattaac ttccgcggag gttggggtac ttcggataat gctgtcaaga atccgaaaaa
     4801 agccgatccg taccagcagc tggaaaatac ctggtatgcc ttgtattatg atgcccttct
     4861 ttatgacggc atgaatatgc aacaggcggg cgattatgct tcgtcgcagg cattgaccaa
     4921 acaggtaaag gctacaaaag attcgaatgg taatctgatt tatgtcactc cgttcagaca
     4981 tatcaatgaa aattacgtat tgcatgacgg caatgggaat ccttacatga atcctaatct
     5041 ggaatatgtc tgggatgaag atgattggga tgtctacaaa gctatcttct cccgtaaact
     5101 gcgccaggat tatagtgtgg atataagtgg tcaggccaat ggtggaaaaa cagcctattt
     5161 cttctccggc ggttatctgg acgaccaggg atatggtaac cggcagtatt ataaacgtta
     5221 ttctttccgt accaacctga gtacagagtt gttcgattgg tggaaagtgg ccggtagcct
     5281 ttcttattcg cgtcatcgcc agaacctttc cggtggtgcc agccgtgcgg ctaactttac
     5341 gacgactttg tcttcaccct ggttacgtaa tgaagataat accggttggg tcgtttctga
     5401 aaaaacaggg gaacggatgt acagttacgg taaatatacc aataacttct ttggtgccca
     5461 tatcctgaat aactcgggtg attattggga taatccgaac gatgacagtt tcgataacaa
     5521 tatggggcat atcctgtctg ctcaggtaaa tacagagttt actcttcctt tcaacctgaa
     5581 attccgttcg gctttgaata ttgacgatta ctggtatcgt accatgcaat atacttccgc
     5641 cgtacatggc agcggacaga ctgcacctta tggtatttct atactggcag acggtggtta
     5701 tgccagccgt tataatttca ataaacgttc caccacctgg aataatgtat tgtctggtga
     5761 atggatgatt ggtgaccata cgatttcagg tctggtcgga catgagtggt atacctggga
     5821 ctcccactac gaacaaggtt ggggtgaagg tatcatggaa ctgggtaaat atgaattatc
     5881 gaataccacc aagaacttcg gtgtttccgg cggacgtgat aaatactctc tgctttcgtt
     5941 ctttggtaag gtcgattata acttcttgaa taagtattac ttgtccgctt cacttcgtga
     6001 ggatggttct tcccgtttca gctccgatca tcgctggggt acattctggt cgacaggcgg
     6061 ttcatggcga atatcgaaag aaggttttat ggaagacctg aaatggattg ataacctttc
     6121 gttgcgtggt agttacggta cgactggtaa tgataagctg atcgtgcgtg aatcgaatgg
     6181 taaggcaggg gatgaagtcc tttacggata ccagggtact tatgaaagtg atgacctgta
     6241 tctgaaatcc ggtttaaaac catctaccta tccgacaccg gacttgaagt gggaaagtaa
     6301 tcagcaatgg aatatcggtt tagatttttc cgtattcaac cgacttagcg gtacagtgga
     6361 atattattcc cgtacttccc atgacttgtt gtattataag gaactgcctc tctctgccca
     6421 ggttggtagt gcatccgggt ataatatgaa tatcggtgac ctgcgtaata gcgggattga
     6481 aatcacattg aatgcgaata tccttacaac gaaagatttc agatgggata tcgatgccaa
     6541 catgagtacg ctgaaaaatg aggtgactta tttgcctaca ggtccttaca cttattctgg
     6601 taccgcctgt acctacaaga tggaggaagg caagtctctg tatgaattta tcgctcccca
     6661 gtacgacggt gttaatccgg aaaccggagt acccggctgg ttgatccgcg atggtaacgg
     6721 cggttggaaa cgtacggaaa agcaggaaga agtaacgaca gacgattttg tgtactgtgg
     6781 ctccgcgatt cccaaagtgt tcggtgctat caccaataac ttccagttca aagggatcga
     6841 cctgtcgttc atgttctatt attcttatgg ttccaaaata tcggactata catataaaga
     6901 acgtatcatg aaccgtccgg gtgtcggtgt gatacaggag ttggttgagg acagatggcg
     6961 tcagccgggc gatgcggatg tgcttatccc acgttggtcg tacaaccagt atggcgcgac
     7021 ggtaaaatat gcagataact tcgtattcga caaccactac tggcgtctga gaaacctgac
     7081 attaggctat acgctgccta agagccttac ccgcaaggcc ctggtagaaa acctgcgtgt
     7141 ttatgtaacc ggtaataacc tgttgacttt cggtcctgcc aaaaaacgct acacagaccc
     7201 cgaaacaggt ataatgggta acagttataa cggtaatgct gaaaccgata acggtattca
     7261 gggttcgaga agactgtata tggtcggtat tcaaatcaca ttgtaaacgt aaaaaatgat
     7321 atttatgaaa cgatttataa atatatcctt cctgtccctg gtttttgctg gtatggccct
     7381 gaccggatgt aacgacgacc tgacaaccag ctcctacgtg aaagtaaacg atgaagatgt
     7441 actggggaat gtctcccagt tggaaaaagt attgacttca gcctataagc agctgtattt
     7501 taatactgat aaaggagacc gtgtgtatgc cggtcttccc ggattccaga tgtatgtcga
     7561 tgcgagtggt gccgacgtga tcagccatac caatatggga ggtgatcagg taacagcata
     7621 ccagtattcc aactcaaaaa cacaggctga cggaaatgcc tcaaaaatct ggtcgatgtg
     7681 ctataatgtg atcaaccgtg ccaatatcat cctgaccaat gtggatgccg ccgccggtga
     7741 tgaaacacag aaaaaacata tcaaaggcca ggcgttggcg atgcgtggaa tccagtattt
     7801 ccatctgatc cagaattacc agcagacgta tgcgatagct aaaagcaagc gtggggtgat
     7861 cctgcgtacc tcttccgatg atgaatccca taaaggtttt tctactgtag aggaagtcta
     7921 tacccagatt gtgtccgacc tgacgacggc taaaacattg cttgccgatt ataatccgga
     7981 cgatatgtgg ctgatcaact ccaaaatatg ttcgggaatc ctggcccgtg tttatctggt
     8041 gatgcagaac tgggacggcg cttacaatga agccaagatc gtctacgacc agcacagcca
     8101 gttgatgacc cgcgaacaat accgttccgg tttcgacgat atgatctccg gcaattatgc
     8161 ggaagtggta tgggccatga aatataccgc cgataataac ctgggcggta gtacgcagtt
     8221 caatttctgg tataaccagg atgccagcta cggcgagggt tatgccgatg gtcctatcta
     8281 ctcgttcctt gactacttcg tggatgagca gtttgtgaaa ctatttgaag aaaaagaaga
     8341 ccgttaccag ttctggaaac gtacgaacaa tgcgaatacg gaaatcaata caaaatgggc
     8401 tttcgacaaa tacaagcatt atggtgaaga cggcggaagc gttattcaaa gcgccacccg
     8461 tccggaagtc tgcctgatgc gcggagccga aatgctgctg attatggcgg aggctgctgc
     8521 ccaaaagggt aactccggcg aggctctgaa tctgctgaac cgtttgcagg tggcgcgtaa
     8581 tgctaccccg acaaccaatg ccggaggcga agctttgctg gaagacatct atgtggaacg
     8641 ccgtaaagag ttgatctgtg aaggacaagc cggtttttat gacctggtgc gcctgcaaaa
     8701 gagattggtt cgtatcggtg aatcaactac caatcctgcc ggacattacg tatggggcat
     8761 gcagtatctg aacggatata atgcgctcga tccgcaaccg atagggacgc tggagtcgaa
     8821 cgattaccgt ttcttctgcc aaatcccgca aatggaaatc ctgaataatg atgcgatctc
     8881 cgaatcagat cagaatccgt ggagcgggca gtaagtttca tctgttgtaa ataaataaaa
     8941 gagagggagg tgtttattac atgcctccct ctcttttatt tgtaacattt gatgttcact
     9001 gttttacttt ttgtccttta gcacttcctg taacatggcc accttctcct gctccgcttt
     9061 caataaacgt tcgtataatt caacgacttt ttctaagggg ttaaatgtag gattataatt
     9121 ctggcaatta gcattatctt gccaggtgcc ggaaaagata ttaatggaag tggcttcgcc
     9181 tagttccgta attgcttctt cgggtatatc taatgctttg gcaatctttt cgattacttc
     9241 cggctccaga ttacttcttt tttcgtatgt cgaaagggtt agtagaaaat aaatccggtt
     9301 tatctctcat aataaatatc ggaaagagtt gcctgataat atttgtacca cagaaaaaac
     9361 acatcaaagg tcaggcgctg gcgatgcgtg gaatccagta ttttcacctg atccagaatt
     9421 accagtaaac gtatgtcatt gcgaaaaata gtttctcttt caaccgataa tagtggacat
     9481 gatatcagtg aaacggttga tgcaaatcag tgtcgtatgg aaacttcact tcctgtaacc
     9541 aaacagacgg caaaatcaaa atgatataaa aatgaatgat atatgaatat tatgagtgta
     9601 aatggccttt ggaggaaaca gacttatttt ttatttgttc attctagaaa agggaagcat
     9661 acatttatta acataacaga tatctgatat cgacttttta tctcgtttaa accgaagaaa
     9721 attttagttt aaacagattt caatttcgtt taaactgaga taaatttcta ttgtagtgga
     9781 gtttttattc gtttagagaa gaaaaacacc tcaattagtg cttttaaaaa agaaaatcat
     9841 atgtttttag acagttttta tttccagagc aaccgctttt tgatgtgtgt gtaaaatagc
     9901 aatatgttaa taaattatga atagatgtgg tatatgggta acaatcatag ataatataca
     9961 ttttttgtga tatgaatatt gcaacaatca ggtcaaagcg aacaaaggta agtcggcgag
    10021 atttctataa aaacagatcg acatttccct ttgcccgtac aattccttca gcacatacat
    10081 aaaatatcat tttgacaatc ctttaacttc caggaactct cctgacgctt tgtatccaat
    10141 agtatgttct ccggatagga cttggctttt atatcccaaa aagtaaatca tcaatagtaa
    10201 acaaggcaac cgcagcaaaa ggatgtttca atatagaaat atttgaacta tcccgttccc
    10261 gtgctcgaca cgggatcgca aaagcacaaa ccgtatccta tatgtatctt ttgatactgc
    10321 ctgttcttct gcggccccgt gtcaagcacg gggacaggat agttcatatc tgataagaaa
    10381 tgaatcaaat tcttttggta tagtttaatc agtcataaaa ggagaggcgt gtctgtgaag
    10441 gtgtgcttct ttcctgtaga taacgggatt taatcccggt agggtttgcc ggaataaatg
    10501 aagaatgtat ctttgtagga gatcgttaac aacttaaaaa gatataccat gaataaaatc
    10561 agtttgctgt ttattttgtc tgtattaatc actttttctg cttatgccca ggatgatata
    10621 aagataacgc atgcccctta tctgcaaaat ctgggagaaa atgaagtcac tgttgtatgg
    10681 actgcaaaca agccttcgat cggctgggtg gaactggctc ctgatgacgg aactcattat
    10741 tatcagacgg agcgtccgaa gttctttaat gcgaagaatg gcatcaagct gacctctacc
    10801 gtccattctg tgcatctgac agggttaaag cccggcacac gttatcgcta ccgggtgtat
    10861 tcgcaggaag tgttaagcca tgtcggctgg cgggtgattt acgggaatgt ggcggcaacg
    10921 tctgtttacg gcaagcaacc gctgacgttc ctgaccagcg atcatggcag gcaatccgtg
    10981 aactttgcca tggtcaacga tatccacgga aaaagtgatg tgctggaaaa actggtttcc
    11041 cattgtgatc tgaaaaagac cgatatgttt ctgttcaatg gcgatatggt ctctattttc
    11101 aacaatgaaa aggaaatatt cgaaggcttt atggataagg caaccgagct tttcgcctcc
    11161 gagataccga tgtactatac ccgtggaaac catgaaaccc gcggttcctt tgctaccgca
    11221 ttccaggact atttctctcc gaaacaggag cacatctatt atatgttccg ccagggatct
    11281 gtctgctttg ttatcctgga cagtggcgaa gataaaccgg attcggatct tgaatatgcc
    11341 ggcataacag tctatgacca gtatcgtacg gaacaggcgg aatggttgaa gaaggtactt
    11401 gaaagcaagg agtataaaga agcaccgttt aaagtcgtag tttgccatat gcctccgttc
    11461 ggtggttggc atggtgagca ggaagttgcc gaaaagttta tccccttact caataatgcc
    11521 ggtgtcgatc tcatgctttg cggccacctt caccggtata tgcggaatga accgaaagac
    11581 ggtgttcgtt ttccggttat tgtaaactcc aataatacgg tattgaaagc ggaagcaggc
    11641 gtaaaagaat taaacatcag gatactggac atggagggga aagaggtgga taagctgaca
    11701 ataaccaaat aagacatata gatgggagaa acatcctccg gctgaactat caaaaatagg
    11761 aagaatagaa tcagttttga aaataacctg ttgaagcaga ggttctatat ttgtacaatc
    11821 ataaaaacgg taatcattgg tataacctaa atagaatctt taatgaaagg tattttcttt
    11881 gtcatatgta tgtgttttgt ctcgtttgga gtatctgccc aggtcagtga gtcagctttt
    11941 gtaaatccgg agaataaata taagcctgtt cctttgtggt tttggaataa tgcgacggtc
    12001 aatgaaaacg aattgctgga ccaattccgt cagatgatcc gaaaagacgg gtatggcggt
    12061 tgtgcaatcc ttcctttcgg gcaagacttc aagccggaat atctgtcaga cgattatttc
    12121 aatctttata gcaagattat agaggaagcc aagaaactgg atgtgcatat gtccctgtat
    12181 gatgagtatg gttttccgag tggaagtatg ggagccatca acgcggatgg ggtacctcgc
    12241 ttcatgaaca aatatccgga tgccacgatc aagcggctgg acaaaatgga gtataaagta
    12301 gctgtcggcg aatcattcga acaggtcgtt cctgccggaa aactgatgtc ggtcgttgca
    12361 atggacacgc tgacgaagca tcggatttcg ctggaacaat atattcgttc cggtaaactc
    12421 aactggaaag ttccggaagg agcctggaag atcatgtttt tcgtctgtgt gaaagatggc
    12481 gacccgaatg tggattatct ggaccctgaa gccgtcaggc tgtttgtaaa agaaactcat
    12541 caggcatatt atgaccgttt ctctccctat ttcgggaata cgatcataga aacttttttt
    12601 gatgaaccga ccctgtaccg ggctaaggga cgtatctgga cagacgcgtt taacgagaaa
    12661 tttatctccc gttacgggga atctcccgaa ttactgtatc cggcattatg gtatgacatc
    12721 ggggaggaaa cgcaatctgc gcggaaccgt ctgtttggct tgcgtgccca tttgtattcc
    12781 gaaggtttta tgaaaataat cggtgaatgg gcttctgccc atggcattta ctctaccggt
    12841 catcaggatc aggaagagat tgcgaatccg gtgggaactt ctggtgactt gatgttgtgc
    12901 gggaaatata tggggattcc cggtattgac aaaattggcg gaggccgtcc gaccgaattg
    12961 ttttataaag tggtttcttc ttctgcctat aactgggaca aacgccaggt aatgtccgaa
    13021 acatacggcg ctatggggaa tatcagtgta aaagagcttt accacatagc catggaacaa
    13081 tatacgaaag gggtcaatac gcttatccca catgctgtct ggtataatga tcggaatgtt
    13141 actttcctgc ctgagttatc ctggcggaac gaactgtacc gcgattcact tccggcattt
    13201 aataagttcc tgtcccgtct caactatatt ttgcggcagg aaggaagaca tgtcgccgat
    13261 atagcagtcc tttatccgat cgaatctctt cagggagaac atgtgatgga tggggaactg
    13321 ggattttatg aaggcggggt aatgatcccg aatacggatt atacacatgt ctcggcttta
    13381 ttgactgata ccctcgggcg tgatttcact tatctgcatc cggaggtctt atctacaaaa
    13441 tgccgtgtga aaaaaggatt gttgcacctc gacaatcagg tgaacaaaga aactttccgg
    13501 ttgattatta ttcccggagt aaaaac
//
