LOCUS       c00050_gnlPro..        13906 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OCEHBCNA_50.
ACCESSION   c00050_gnlPro..
VERSION     c00050_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 13:21:54
            Original ID  :: gnl|Prokka|OCEHBCNA_50
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13906
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13906
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3922]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3922
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..13906
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13906
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             3..1499
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_1"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.4e-51, bitscore:
                     162.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="TTIITLTPSTAPIIWRDFKDSMALPTSSTPMVVIAGQVPSPLLGT
                     DAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLDLAKDAQVGL
                     VDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGGAEEELKEFL
                     LKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIGMRFDDRVTG
                     DLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERKRPEWNAEFE
                     PDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQMMGVRYFKYK
                     QTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELGTIMQENLNV
                     KIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVDKREDLDEAI
                     AEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             1512..2066
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_2"
                     /sec_met_domain="ALS_ss_C (E-value: 1e-18, bitscore: 56.7,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             2103..2834
                     /locus_tag="ctg50_3"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLTDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYSVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSLD
                     KYNMAICNDGKAISRAAVTWI"
     CDS             2876..3922
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg50_4"
                     /sec_met_domain="IlvN (E-value: 1.1e-48, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.5e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             4423..7701
                     /locus_tag="ctg50_5"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGTITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWI
                     DNLSLRGSYGTTGNDKLIVRESNGKAGDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDL
                     KWESNQQWNIGLDFSVFNRLSGTVEYYSRTSHDLLYYKELPLSAQVGSASGYNMNIGDL
                     RNSGIEITLNANILTTKDFRWDIDANMSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSL
                     YEFIAPQYDGVNPETGVPGWLIRDGNGGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITN
                     NFQFKGIDLSFMFYYSYGSKISDYTYKERIMNRPGVGVIQELVEDRWRQPGDADVLIPR
                     WSYNQYGATVKYADNFVFDNHYWRLRNLTLGYTLPKSLTRKALVENLRVYVTGNNLLTF
                     GPAKKRYTDPETGIMGNSYNGNAETDNGIQGSRRLYMVGIQITL"
     CDS             7720..9309
                     /locus_tag="ctg50_6"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYAIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHSQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKWAFDKYKHYGEDGGSVIQSATRPEVCLMRGAEMLLIMAEAAA
                     QKGNSGEALNLLNRLQVARNATPTTNAGGEALLEDIYVERRKELICEGQAGFYDLVRLQ
                     KRLVRIGESTTNPAGHYVWGMQYLNGYNALDPQPIGTLESNDYRFFCQIPQMEILNNDA
                     ISESDQNPWSGQ"
     CDS             9978..10082
                     /locus_tag="ctg50_7"
                     /transl_table=11
                     /translation="MNIMSVNGLWRKQTYFLFVHSRKGKHTFINITDI"
     CDS             10944..12107
                     /locus_tag="ctg50_8"
                     /transl_table=11
                     /translation="MNKISLLFILSVLITFSAYAQDDIKITHAPYLQNLGENEVTVVWT
                     ANKPSIGWVELAPDDGTHYYQTERPKFFNAKNGIKLTSTVHSVHLTGLKPGTRYRYRVY
                     SQEVLSHVGWRVIYGNVAATSVYGKQPLTFLTSDHGRQSVNFAMVNDIHGKSDVLEKLV
                     SHCDLKKTDMFLFNGDMVSIFNNEKEIFEGFMDKATELFASEIPMYYTRGNHETRGSFA
                     TAFQDYFSPKQEHIYYMFRQGSVCFVILDSGEDKPDSDLEYAGITVYDQYRTEQAEWLK
                     KVLESKEYKEAPFKVVVCHMPPFGGWHGEQEVAEKFIPLLNNAGVDLMLCGHLHRYMRN
                     EPKDGVRFPVIVNSNNTVLKAEAGVKELNIRILDMEGKEVDKLTITK"
     CDS             12258..13904
                     /locus_tag="ctg50_9"
                     /transl_table=11
                     /translation="MKGIFFVICMCFVSFGVSAQVSESAFVNPENKYKPVPLWFWNNAT
                     VNENELLDQFRQMIRKDGYGGCAILPFGQDFKPEYLSDDYFNLYSKIIEEAKKLDVHMS
                     LYDEYGFPSGSMGAINADGVPRFMNKYPDATIKRLDKMEYKVAVGESFEQVVPAGKLMS
                     VVAMDTLTKHRISLEQYIRSGKLNWKVPEGAWKIMFFVCVKDGDPNVDYLDPEAVRLFV
                     KETHQAYYDRFSPYFGNTIIETFFDEPTLYRAKGRIWTDAFNEKFISRYGESPELLYPA
                     LWYDIGEETQSARNRLFGLRAHLYSEGFMKIIGEWASAHGIYSTGHQDQEEIANPVGTS
                     GDLMLCGKYMGIPGIDKIGGGRPTELFYKVVSSSAYNWDKRQVMSETYGAMGNISVKEL
                     YHIAMEQYTKGVNTLIPHAVWYNDRNVTFLPELSWRNELYRDSLPAFNKFLSRLNYILR
                     QEGRHVADIAVLYPIESLQGEHVMDGELGFYEGGVMIPNTDYTHVSALLTDTLGRDFTY
                     LHPEVLSTKCRVKKGLLHLDNQVNKETFRLII"
ORIGIN
        1 ataccacaat cataacgctg acacccagca ctgctcccat aatctggcgg gacttcaaag
       61 attccatggc actgcccacc agcagtacac cgatggtggt gattgccggc caggttccgt
      121 ctccgctgct tggaacagat gctttccagg aagttgatgt gatcggtatc acacaaccga
      181 ttaccaaatg ggcttaccag atacgccgcc cggaagaaat tgcttgggcc gtttcccgtg
      241 ctttctatat cgcatcgacc ggtcgcccgg gacctgtggt actggatttg gcgaaagatg
      301 cacaggtggg tttggtagat tatgagtatc agaaagtgga ttatgttcgt agttaccaac
      361 ctgaaccgga tatcagggag gaacgtatcg aggcggctgc ttcattgata aataatgcca
      421 aaaagccatt ctgtctggta gggcaggggg ttatcctggg aggagctgaa gaagaactga
      481 aagaattctt gttgaaaaac gatataccag ccggttctac cgtattgggc ttgtctgcat
      541 taccttcgga cttcccatta aataaaggta tgttggggat gcatggaaat gtcggaccga
      601 accgcaagac aaacgaatgt gacgtgctga ttgctatcgg tatgcgtttc gatgatcgcg
      661 taaccggcga cctgaagact tatgccaagc aggcaaagat tatccacctg gatatcgaca
      721 attcggagat cggaaagaat gtgccggtcg acgtgaaagt gctgggaaat gccaagcata
      781 cgattccgat gattacggct ttactggaag aacggaagcg tccggaatgg aatgctgaat
      841 tcgaaccgga tgaaaaagag gaatataata aggtaataga aaaagaactc tatcctaccg
      901 aaggccaact gaaaatgggc gaagtagtcc gtaaggtttc cgaagcaacc gataatgatg
      961 cgattctggt tacggatgta ggtcagaacc agatgatggg tgttcgctat ttcaaatata
     1021 aacaaacacg cagcgtagtt acttcaggag gtttgggaac gatgggcttt ggccttcccg
     1081 ccgccattgg agcgaagctg ggagcgcctg accgtacggt ctgtttcttt accggcgacg
     1141 gtggtatcca gatgactatc caggagttgg gaactatcat gcaggaaaat ctgaatgtaa
     1201 agatcatcgt tcttaacaac aatttcctgg gaatggtacg ccagtggcag gagctgttct
     1261 tcaacgaacg gtattcgaat accatcatga agaatccgga ttttgtagcg atagccaagg
     1321 cttttggtat tgcttcccgt gcggtagata aacgggaaga cttggatgag gcgattgctg
     1381 aaatgttgaa tcacgatggt gcctatatgt tggttgccaa tgtggaaact tgtggtatgg
     1441 tatatccgat ggttccggcc ggaggaagcg tgacaaacat gattttgggt gataagtaag
     1501 gaggagaaac tatgaataca aaacaattat ataccgttat tatcttttcg gaaaacactg
     1561 ttggtcttct gaatcagata actgttatct ttacgcgccg gcaactgaac attgagacgc
     1621 tttctgtttc tccctctgct ataaagggaa tacataagtt tacaattact acctttgccg
     1681 acgaggatac gatcgacaag gtcgtaaaac agatcgacaa gcgtgtggat atcctgaaag
     1741 cctattataa tacggatgaa gacctggttt accaggaaat cgctctttat aaactgagta
     1801 ccgaactctt tatcaagatg gggacggttg aggatctgat ccgtaagtac aatgcccgta
     1861 tccttgaaat gaatgaggat tgtgtggtgt tggaaaagag tggtcattat gatgagacac
     1921 aggctttgtt taaagaattg agtgagacga tcggtgtcct gcaatttatc cgttccggac
     1981 gcgttgctat aacgaagagt aaggtagaac gtctgagcga catgttatct gcaatggaaa
     2041 agaagttgca ggaaaaacat gtctgagaat aataaggaaa cattttgtaa ataaagtaaa
     2101 ttatggagaa gaacaaagta ggagaatttc atttcgtaac agagtcttat ctgacggact
     2161 tccggggacg tattacaatc cctatgatcg gaacttattt gttgcatgct gcttcttgcc
     2221 atgccgccga ccgtggattc ggatataacg atatgaccga aaggcatacc gcctgggttc
     2281 tttcccgtct ggctatcgag atgacttctt atcctgccat gtctgaatcc gtaactttat
     2341 atacctgggt ggatgaggtc ggtaagttgt ttaccagccg ttgctttgaa ctggtgaacg
     2401 gcgaaggcaa gacctttggc tttgcccgct ctatctgggc ggctatcgat atggaaaccc
     2461 gccgcccgac cttgctcgat gtggagggcc tgagtgctta tatcaccgac cgtccctgtc
     2521 cgattgaaaa accgggtaaa attgctccgg tggaaaacaa cacttccggc gaaccttaca
     2581 gtgtgaagta tagtgacctg gacgtaaacg gccacctgaa cagtatcaaa tacatggaac
     2641 acctgctcga cttgttcgat atcagtctgt tccgagaaaa agagataagc cgtttcgaaa
     2701 tagcttatca gtccgaagga aagtatggga tggagctgac tctccataac caggaagtat
     2761 ccctcgataa atataatatg gcaatctgta acgacggcaa agccatcagc cgcgctgccg
     2821 ttacctggat ctgaaaaaca aattatttta tatacatttt aatagtaaaa agaaaatggc
     2881 agtaatgaat tttggcggcg ttgacgaaaa cgtagtaacc cgcgaagaat ttccgttgga
     2941 aaaggcaaga gaagtattga aagacgaaac aatcgctgta ataggttacg gcgtacaagg
     3001 tcctggccag agcctgaacc tgcgcgacaa cggttttaac gtaattgtag gacaacgtaa
     3061 aggtggtaag acctgggaaa aggccgttgc tgacggttgg gtaccgggcg aaacactgtt
     3121 cgatatcgaa gaagcatgcg aaaaagcaac tatcatccag tatctgcttt cagatgctgc
     3181 tcagattgaa gtttggccgc gcatcaaaaa atacctgact ccgggtaagg ctttgtattt
     3241 ctctcacgga ttcggtatca cttacaaaga acgtacaaac atcatccctc ctgctgatgt
     3301 agacgtaatc ctggttgctc cgaaaggttc aggtacttca ctgcgccgta tgttcttgca
     3361 gggtcgtggt ctgaactcaa gctacgcaat cttccaggat gcaacaggca aagcatggga
     3421 tcgcgtgatt gcactgggta tcggtgttgg ttctggttac ttgtttgaaa caacattcaa
     3481 gaaagaagtt tattctgacc tgaccggcga acgtggtact ttgatgggag ctatccaggg
     3541 attactgttg gctcagtacg aaactttgcg tgaaaacggt cacgaacctt ctgaagcatt
     3601 caatgaaaca gtagaagaac tgactcagtc attgatgccg ttgttcgcag aaaacggtat
     3661 ggactggatg tatgcaaact gttcaacaac tgcacagcgt ggtgctttgg actggatggg
     3721 cccgttccac gatgctacaa aaccggtgtt ccagaagttg tatagcgaag ttgcctgcgg
     3781 taacgaagca cagcgttcta tcgacacaaa cagcaagcct gactatcgtg aaggtctgga
     3841 aaaagaactg gctgctcttc gcgaaagtga aatgtggcgt gcaggtgctg ttgttcgtaa
     3901 acttcgtcct gaaaacaact aataaatggt gatacattaa tagttaaaca ttttgtgata
     3961 taaaaacggc aatccggctt ttcgggttgc cgttttttat ggtttatgta atgcgttaat
     4021 ggttaaaaaa tgtttttgat tgcaactgtt attgattttt catcccaata tgtatgtcat
     4081 tgtttgaatg tggattttag ataaaaaaat caattaaatg gtggttaaaa tatatttatt
     4141 agagcaataa atatacataa ttatgcttgt attaaataat gataagttat atttgctgat
     4201 ggagatactg tagtttgtag agtggaaata tagaaggatg ttgtgtgtaa tgatcagtat
     4261 atctttgttt tagttaactt tattttattg aaatgtatgc cagtcacttt tatcttagaa
     4321 aagtgtaacc tctaatgaaa tgaacgctat tgtgattaat tttatttaat taaagacttg
     4381 aatttagcta tgtggaccaa ctcaaaacta attagatcac taatgatttc tgtattatta
     4441 ggtgcggcag gtgcgattgc tgccaatcct acaggtccgg aaacgatggt agtacaacag
     4501 ggtaataagg taaccggcct ggtagaggac cagatgggac ctgtcgccgg agcttctgtt
     4561 gtagtgaaag gaaccactat cggtacgata accgatatcg atggaaagtt tacgctggat
     4621 aatgttcggc ggggagcggt tattgttatt tcctttgtcg gcctggccac tcaggagatc
     4681 acttggaacg gacaatctat tttaaatgta aaattaagtg atgcgacaca ggacctggat
     4741 gaagtcgttg tcgtagccta tggaacggct aagaaatcaa ccttcaccgg atcggcctcc
     4801 gttgtaaaag ctgaaaaact cgaaaagatc atgggctccg gctttgcgga agcattgcag
     4861 gggatgagtg ccggtgtgaa tgttgtgaat gtacagggta accccggagc tgatgcccgt
     4921 gtggagatcc gtggtattgc ttccatgtcc ggaaaggccg atccgttata tattgtggac
     4981 gggatgcctt acgatggaaa actgaatcag atcaatccta cggacataga atcgatgacg
     5041 gtgctgaagg atgcggcggc cacttcgctc tacggttcgc gtgcagcaaa cggcgtcgta
     5101 atgattacaa ccaagcgggg taaatcagaa aaaccgcgta ttaacttccg cggaggttgg
     5161 ggtacttcgg ataatgctgt caagaatccg aaaaaagccg atccgtacca gcagctggaa
     5221 aatacctggt atgccttgta ttatgatgcc cttctttatg acggcatgaa tatgcaacag
     5281 gcgggcgatt atgcttcgtc gcaggcattg accaaacagg taaaggctac aaaagattcg
     5341 aatggtaatc tgatttatgt cactccgttc agacatatca atgaaaatta cgtattgcat
     5401 gacggcaatg ggaatcctta catgaatcct aatctggaat atgtctggga tgaagatgat
     5461 tgggatgtct acaaagctat cttctcccgt aaactgcgcc aggattatag tgtggatata
     5521 agtggtcagg ccaatggtgg aaaaacagcc tatttcttct ccggcggtta tctggacgac
     5581 cagggatatg gtaaccggca gtattataaa cgttattctt tccgtaccaa cctgagtaca
     5641 gagttgttcg attggtggaa agtggccggt agcctttctt attcgcgtca tcgccagaac
     5701 ctttccggtg gtgccagccg tgcggctaac tttacgacga ctttgtcttc accctggtta
     5761 cgtaatgaag ataataccgg ttgggtcgtt tctgaaaaaa caggggaacg gatgtacagt
     5821 tacggtaaat ataccaataa cttctttggt gcccatatcc tgaataactc gggtgattat
     5881 tgggataatc cgaacgatga cagtttcgat aacaatatgg ggcatatcct gtctgctcag
     5941 gtaaatacag agtttactct tcctttcaac ctgaaattcc gttcggcttt gaatattgac
     6001 gattactggt atcgtaccat gcaatatact tccgccgtac atggcagcgg acagactgca
     6061 ccttatggta tttctatact ggcagacggt ggttatgcca gccgttataa tttcaataaa
     6121 cgttccacca cctggaataa tgtattgtct ggtgaatgga tgattggtga ccatacgatt
     6181 tcaggtctgg tcggacatga gtggtatacc tgggactccc actacgaaca aggttggggt
     6241 gaaggtatca tggaactggg taaatatgaa ttatcgaata ccaccaagaa cttcggtgtt
     6301 tccggcggac gtgataaata ctctctgctt tcgttctttg gtaaggtcga ttataacttc
     6361 ttgaataagt attacttgtc cgcttcactt cgtgaggatg gttcttcccg tttcagctcc
     6421 gatcatcgct ggggtacatt ctggtcgaca ggcggttcat ggcgaatatc gaaagaaggt
     6481 tttatggaag acctgaaatg gattgataac ctttcgttgc gtggtagtta cggtacgact
     6541 ggtaatgata agctgatcgt gcgtgaatcg aatggtaagg caggggatga agtcctttac
     6601 ggataccagg gtacttatga aagtgatgac ctgtatctga aatccggttt aaaaccatct
     6661 acctatccga caccggactt gaagtgggaa agtaatcagc aatggaatat cggtttagat
     6721 ttttccgtat tcaaccgact tagcggtaca gtggaatatt attcccgtac ttcccatgac
     6781 ttgttgtatt ataaggaact gcctctctct gcccaggttg gtagtgcatc cgggtataat
     6841 atgaatatcg gtgacctgcg taatagcggg attgaaatca cattgaatgc gaatatcctt
     6901 acaacgaaag atttcagatg ggatatcgat gccaacatga gtacgctgaa aaatgaggtg
     6961 acttatttgc ctacaggtcc ttacacttat tctggtaccg cctgtaccta caagatggag
     7021 gaaggcaagt ctctgtatga atttatcgct ccccagtacg acggtgttaa tccggaaacc
     7081 ggagtacccg gctggttgat ccgcgatggt aacggcggtt ggaaacgtac ggaaaagcag
     7141 gaagaagtaa cgacagacga ttttgtgtac tgtggctccg cgattcccaa agtgttcggt
     7201 gctatcacca ataacttcca gttcaaaggg atcgacctgt cgttcatgtt ctattattct
     7261 tatggttcca aaatatcgga ctatacatat aaagaacgta tcatgaaccg tccgggtgtc
     7321 ggtgtgatac aggagttggt tgaggacaga tggcgtcagc cgggcgatgc ggatgtgctt
     7381 atcccacgtt ggtcgtacaa ccagtatggc gcgacggtaa aatatgcaga taacttcgta
     7441 ttcgacaacc actactggcg tctgagaaac ctgacattag gctatacgct gcctaagagc
     7501 cttacccgca aggccctggt agaaaacctg cgtgtttatg taaccggtaa taacctgttg
     7561 actttcggtc ctgccaaaaa acgctacaca gaccccgaaa caggtataat gggtaacagt
     7621 tataacggta atgctgaaac cgataacggt attcagggtt cgagaagact gtatatggtc
     7681 ggtattcaaa tcacattgta aacgtaaaaa atgatattta tgaaacgatt tataaatata
     7741 tccttcctgt ccctggtttt tgctggtatg gccctgaccg gatgtaacga cgacctgaca
     7801 accagctcct acgtgaaagt aaacgatgaa gatgtactgg ggaatgtctc ccagttggaa
     7861 aaagtattga cttcagccta taagcagctg tattttaata ctgataaagg agaccgtgtg
     7921 tatgccggtc ttcccggatt ccagatgtat gtcgatgcga gtggtgccga cgtgatcagc
     7981 cataccaata tgggaggtga tcaggtaaca gcataccagt attccaactc aaaaacacag
     8041 gctgacggaa atgcctcaaa aatctggtcg atgtgctata atgtgatcaa ccgtgccaat
     8101 atcatcctga ccaatgtgga tgccgccgcc ggtgatgaaa cacagaaaaa acatatcaaa
     8161 ggccaggcgt tggcgatgcg tggaatccag tatttccatc tgatccagaa ttaccagcag
     8221 acgtatgcga tagctaaaag caagcgtggg gtgatcctgc gtacctcttc cgatgatgaa
     8281 tcccataaag gtttttctac tgtagaggaa gtctataccc agattgtgtc cgacctgacg
     8341 acggctaaaa cattgcttgc cgattataat ccggacgata tgtggctgat caactccaaa
     8401 atatgttcgg gaatcctggc ccgtgtttat ctggtgatgc agaactggga cggcgcttac
     8461 aatgaagcca agatcgtcta cgaccagcac agccagttga tgacccgcga acaataccgt
     8521 tccggtttcg acgatatgat ctccggcaat tatgcggaag tggtatgggc catgaaatat
     8581 accgccgata ataacctggg cggtagtacg cagttcaatt tctggtataa ccaggatgcc
     8641 agctacggcg agggttatgc cgatggtcct atctactcgt tccttgacta cttcgtggat
     8701 gagcagtttg tgaaactatt tgaagaaaaa gaagaccgtt accagttctg gaaacgtacg
     8761 aacaatgcga atacggaaat caatacaaaa tgggctttcg acaaatacaa gcattatggt
     8821 gaagacggcg gaagcgttat tcaaagcgcc acccgtccgg aagtctgcct gatgcgcgga
     8881 gccgaaatgc tgctgattat ggcggaggct gctgcccaaa agggtaactc cggcgaggct
     8941 ctgaatctgc tgaaccgttt gcaggtggcg cgtaatgcta ccccgacaac caatgccgga
     9001 ggcgaagctt tgctggaaga catctatgtg gaacgccgta aagagttgat ctgtgaagga
     9061 caagccggtt tttatgacct ggtgcgcctg caaaagagat tggttcgtat cggtgaatca
     9121 actaccaatc ctgccggaca ttacgtatgg ggcatgcagt atctgaacgg atataatgcg
     9181 ctcgatccgc aaccgatagg gacgctggag tcgaacgatt accgtttctt ctgccaaatc
     9241 ccgcaaatgg aaatcctgaa taatgatgcg atctccgaat cagatcagaa tccgtggagc
     9301 gggcagtaag tttcatctgt tgtaaataaa taaaagagag ggaggtgttt attacatgcc
     9361 tccctctctt ttatttgtaa catttgatgt tcactgtttt actttttgtc ctttagcact
     9421 tcctgtaaca tggccacctt ctcctgctcc gctttcaata aacgttcgta taattcaacg
     9481 actttttcta aggggttaaa tgtaggatta taattctggc aattagcatt atcttgccag
     9541 gtgccggaaa agatattaat ggaagtggct tcgcctagtt ccgtaattgc ttcttcgggt
     9601 atatctaatg ctttggcaat cttttcgatt acttccggct ccagattact tcttttttcg
     9661 tatgtcgaaa gggttagtag aaaataaatc cggtttatct ctcataataa atatcggaaa
     9721 gagttgcctg ataatatttg taccacagaa aaaacacatc aaaggtcagg cgctggcgat
     9781 gcgtggaatc cagtattttc acctgatcca gaattaccag taaacgtatg tcattgcgaa
     9841 aaatagtttc tctttcaacc gataatagtg gacatgatat cagtgaaacg gttgatgcaa
     9901 atcagtgtcg tatggaaact tcacttcctg taaccaaaca gacggcaaaa tcaaaatgat
     9961 ataaaaatga atgatatatg aatattatga gtgtaaatgg cctttggagg aaacagactt
    10021 attttttatt tgttcattct agaaaaggga agcatacatt tattaacata acagatatct
    10081 gatatcgact ttttatctcg tttaaaccga agaaaatttt agtttaaaca gatttcaatt
    10141 tcgtttaaac tgagataaat ttctattgta gtggagtttt tattcgttta gagaagaaaa
    10201 acacctcaat tagtgctttt aaaaaagaaa atcatatgtt tttagacagt ttttatttcc
    10261 agagcaaccg ctttttgatg tgtgtgtaaa atagcaatat gttaataaat tatgaataga
    10321 tgtggtatat gggtaacaat catagataat atacattttt tgtgatatga atattgcaac
    10381 aatcaggtca aagcgaacaa aggtaagtcg gcgagatttc tataaaaaca gatcgacatt
    10441 tccctttgcc cgtacaattc cttcagcaca tacataaaat atcattttga caatccttta
    10501 acttccagga actctcctga cgctttgtat ccaatagtat gttctccgga taggacttgg
    10561 cttttatatc ccaaaaagta aatcatcaat agtaaacaag gcaaccgcag caaaaggatg
    10621 tttcaatata gaaatatttg aactatcccg ttcccgtgct cgacacggga tcgcaaaagc
    10681 acaaaccgta tcctatatgt atcttttgat actgcctgtt cttctgcggc cccgtgtcaa
    10741 gcacggggac aggatagttc atatctgata agaaatgaat caaattcttt tggtatagtt
    10801 taatcagtca taaaaggaga ggcgtgtctg tgaaggtgtg cttctttcct gtagataacg
    10861 ggatttaatc ccggtagggt ttgccggaat aaatgaagaa tgtatctttg taggagatcg
    10921 ttaacaactt aaaaagatat accatgaata aaatcagttt gctgtttatt ttgtctgtat
    10981 taatcacttt ttctgcttat gcccaggatg atataaagat aacgcatgcc ccttatctgc
    11041 aaaatctggg agaaaatgaa gtcactgttg tatggactgc aaacaagcct tcgatcggct
    11101 gggtggaact ggctcctgat gacggaactc attattatca gacggagcgt ccgaagttct
    11161 ttaatgcgaa gaatggcatc aagctgacct ctaccgtcca ttctgtgcat ctgacagggt
    11221 taaagcccgg cacacgttat cgctaccggg tgtattcgca ggaagtgtta agccatgtcg
    11281 gctggcgggt gatttacggg aatgtggcgg caacgtctgt ttacggcaag caaccgctga
    11341 cgttcctgac cagcgatcat ggcaggcaat ccgtgaactt tgccatggtc aacgatatcc
    11401 acggaaaaag tgatgtgctg gaaaaactgg tttcccattg tgatctgaaa aagaccgata
    11461 tgtttctgtt caatggcgat atggtctcta ttttcaacaa tgaaaaggaa atattcgaag
    11521 gctttatgga taaggcaacc gagcttttcg cctccgagat accgatgtac tatacccgtg
    11581 gaaaccatga aacccgcggt tcctttgcta ccgcattcca ggactatttc tctccgaaac
    11641 aggagcacat ctattatatg ttccgccagg gatctgtctg ctttgttatc ctggacagtg
    11701 gcgaagataa accggattcg gatcttgaat atgccggcat aacagtctat gaccagtatc
    11761 gtacggaaca ggcggaatgg ttgaagaagg tacttgaaag caaggagtat aaagaagcac
    11821 cgtttaaagt cgtagtttgc catatgcctc cgttcggtgg ttggcatggt gagcaggaag
    11881 ttgccgaaaa gtttatcccc ttactcaata atgccggtgt cgatctcatg ctttgcggcc
    11941 accttcaccg gtatatgcgg aatgaaccga aagacggtgt tcgttttccg gttattgtaa
    12001 actccaataa tacggtattg aaagcggaag caggcgtaaa agaattaaac atcaggatac
    12061 tggacatgga ggggaaagag gtggataagc tgacaataac caaataagac atatagatgg
    12121 gagaaacatc ctccggctga actatcaaaa ataggaagaa tagaatcagt tttgaaaata
    12181 acctgttgaa gcagaggttc tatatttgta caatcataaa aacggtaatc attggtataa
    12241 cctaaataga atctttaatg aaaggtattt tctttgtcat atgtatgtgt tttgtctcgt
    12301 ttggagtatc tgcccaggtc agtgagtcag cttttgtaaa tccggagaat aaatataagc
    12361 ctgttccttt gtggttttgg aataatgcga cggtcaatga aaacgaattg ctggaccaat
    12421 tccgtcagat gatccgaaaa gacgggtatg gcggttgtgc aatccttcct ttcgggcaag
    12481 acttcaagcc ggaatatctg tcagacgatt atttcaatct ttatagcaag attatagagg
    12541 aagccaagaa actggatgtg catatgtccc tgtatgatga gtatggtttt ccgagtggaa
    12601 gtatgggagc catcaacgcg gatggggtac ctcgcttcat gaacaaatat ccggatgcca
    12661 cgatcaagcg gctggacaaa atggagtata aagtagctgt cggcgaatca ttcgaacagg
    12721 tcgttcctgc cggaaaactg atgtcggtcg ttgcaatgga cacgctgacg aagcatcgga
    12781 tttcgctgga acaatatatt cgttccggta aactcaactg gaaagttccg gaaggagcct
    12841 ggaagatcat gtttttcgtc tgtgtgaaag atggcgaccc gaatgtggat tatctggacc
    12901 ctgaagccgt caggctgttt gtaaaagaaa ctcatcaggc atattatgac cgtttctctc
    12961 cctatttcgg gaatacgatc atagaaactt tttttgatga accgaccctg taccgggcta
    13021 agggacgtat ctggacagac gcgtttaacg agaaatttat ctcccgttac ggggaatctc
    13081 ccgaattact gtatccggca ttatggtatg acatcgggga ggaaacgcaa tctgcgcgga
    13141 accgtctgtt tggcttgcgt gcccatttgt attccgaagg ttttatgaaa ataatcggtg
    13201 aatgggcttc tgcccatggc atttactcta ccggtcatca ggatcaggaa gagattgcga
    13261 atccggtggg aacttctggt gacttgatgt tgtgcgggaa atatatgggg attcccggta
    13321 ttgacaaaat tggcggaggc cgtccgaccg aattgtttta taaagtggtt tcttcttctg
    13381 cctataactg ggacaaacgc caggtaatgt ccgaaacata cggcgctatg gggaatatca
    13441 gtgtaaaaga gctttaccac atagccatgg aacaatatac gaaaggggtc aatacgctta
    13501 tcccacatgc tgtctggtat aatgatcgga atgttacttt cctgcctgag ttatcctggc
    13561 ggaacgaact gtaccgcgat tcacttccgg catttaataa gttcctgtcc cgtctcaact
    13621 atattttgcg gcaggaagga agacatgtcg ccgatatagc agtcctttat ccgatcgaat
    13681 ctcttcaggg agaacatgtg atggatgggg aactgggatt ttatgaaggc ggggtaatga
    13741 tcccgaatac ggattataca catgtctcgg ctttattgac tgataccctc gggcgtgatt
    13801 tcacttatct gcatccggag gtcttatcta caaaatgccg tgtgaaaaaa ggattgttgc
    13861 acctcgacaa tcaggtgaac aaagaaactt tccggttgat tattat
//
