LOCUS       c00064_gnlPro..        14390 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IABAIMCC_64.
ACCESSION   c00064_gnlPro..
VERSION     c00064_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 07:52:55
            Original ID  :: gnl|Prokka|IABAIMCC_64
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 1839
            Orig. end    :: 16229
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14390
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11839:16027]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..14188
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14390
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14390
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(848..1729)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Oxidored_FMN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_4"
                     /sec_met_domain="Oxidored_FMN (E-value: 1.7e-33, bitscore:
                     106.4, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVGASSGFNLYSPTFVRGLRADELPEMARAYGRSVNLAREAGFD
                     SVEIHAGHGYLISQFLSPSTNHRKDEFGGSLQNRMRFMDMVMEEVMKAAGSDMAVLVKM
                     NMRDGFRGGMELDETMQVARRLEQSGAHALVLSGGFVSKAPMYVMRGEMPIRSMTHYMT
                     CWWLKYGVRMVGKWMIPSVPFKEAYFLEDALKFRAALKIPLVYVGGLVSRDKIDEVLDD
                     GFEAVQMARALLNEPGFVNRMRAEENARCNCRHSNYCIARMYSIEMACHQHLKEELPPC
                     LKKEIEKIEAKG"
     CDS             complement(1821..2066)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Oxidored_FMN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg64_5"
                     /sec_met_domain="Oxidored_FMN (E-value: 1e-09, bitscore:
                     28.3, seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MESKLFTPVTFGPLTLRNRTIRSAAFESMCPGNAPSDMLLDYHRS
                     VAAGGIGMTTVAYAAVTQSGLSFDRQLWMRXXXXTP"
     CDS             complement(2125..2898)
                     /locus_tag="ctg64_6"
                     /transl_table=11
                     /translation="MNQETFQIFLWVMSAVALVVFIALYFVKAGYGMFRTASWGISINN
                     KLAWVLMEAPVFIVMFGLWGKSGAGFAVPVYFFFLLFQLHYLQRAFIFPFLLKGKSRMP
                     VAIMAMGIVFNLLNGMMQAGGXXXXFAPEGLYADGWAYLLKPHALLGIILFFAGMFVNL
                     HSDYVIRHLRRPGDTKHYLPGKGLYRYVTSANYFGELVEWTGFAILTASPAAWVFVWWT
                     FANLVPRADAIHRRYREEFGDEAVGKRKRIIPFLY"
     CDS             complement(3146..4489)
                     /locus_tag="ctg64_7"
                     /transl_table=11
                     /translation="MKKEYLIYKLSEDLKEATRIENELFRKFDVKRGLRNEDGTGVLVG
                     LTKIGNVVGYERIPGGGLKPIPGKLFYRGYDVDDLAHAIIKEKRFGFEEIAYLLLSGRL
                     PDKEELSSFRELINDNMPLEQKTKMNIIELEGNNIMNILARSVLEMYRFDPDADDTSRD
                     NLMRQSIELISKFPTIIAYAYNMLRHATHGRSLHIRHPQENLSIAENFLYMLKKDYTEL
                     DARTLDLLLVLQAEHGGGNNSTFTVRVTSSTGTDTYSSIAAGIGSLKGPLHGGANIQVA
                     DMFHHLQENIQDWTNVDEIDTYFTRMLNKEVYNKTGLIYGIGHAVYTISDPRAILLKEL
                     ARDLAREKGKEREFAFLELLEERAIDVFGRVKNNGKTVSSNVDFYSGFVYEMIGLPQEI
                     FTPLFAMARIVGWCAHRNEELNFEGKRIIRPAYKNVLDEVTYVPIKKR"
     CDS             complement(4502..5191)
                     /locus_tag="ctg64_8"
                     /transl_table=11
                     /translation="MGVTKVRFPETSSFGVKPVSREGTERLVRAACRYALEHHLPSVTL
                     VHKGNIMKFTEGGFKKWGYELAEREFGKELAEGRLVIKDCIADAFLQNTLLIPEEYSVI
                     ATLNLNGDYVSDQLAAMVGGIGIAPGANINYKTGHAIFEATHGTAPNIAGKDIVNPCSI
                     ILSAVMMLEYLGWKEAASLIENALEESFTEARATADLARFMPGSVSLSTSTFTREIVRR
                     IENGNNE"
     CDS             complement(5182..5670)
                     /locus_tag="ctg64_9"
                     /transl_table=11
                     /translation="MEKITVPFITGDGVGAEVTPSMQAVVNAAVKKSYGDRRGIEWKEV
                     LAGERAFHETGSWLPDETMEAFRTYKVGIKGPLTTPVGGGIRSLNVALRQTLDLYVCQR
                     PVRWYKGIVSPLKEPQKVDMCVFRENTEDIYAGIEWEAXXXXXRRLKSSIVFSVMTWG"
     CDS             complement(5674..7455)
                     /locus_tag="ctg64_10"
                     /transl_table=11
                     /translation="MMVGTDSHTPNAGGLGMVAIGVGGADAVDVMTGMEWELKKPRLIG
                     VHLKGKLSGWVAPKDVILKLAGILTVKGGTNAIIEYFGPGTASLSATGKATICNMGAEV
                     GATTSLFPYDERMGTYLKATGREEVAEMAASVAADLRADDEVLANPEKYYDRIIEIDLS
                     LLEPYINGPFTPDAATPISKFAEVVITNNYPRRMEVGLIGSCTNSSYQDLSRAASLARQ
                     VKEKNLKVASSLIVNPGSEQIRATAERDGMIAAFEDIGATIMANACGPCIGQWKRHTDD
                     PERKNSIVTSFNRNFAKRADGNPNTFAYVASPEITMALTIAGDLCFDPLRDTLVNAKGE
                     VVKLSEPVGEELPAHGFIGGKEGYIAPGKGQTEITVNPHSQRLQLLTPFPAWDGMDLLD
                     MPLLIKVQGKCTTDHISMAGPWLRFRGHLENISDNMLMGAVNAFNGETNKVWNRSTNTY
                     GTVSGTAKLYKSEGIPSMVVAEENYGEGSSREHAAMEPRFLNVRVILAKSFARIHETNL
                     KKQGMLALTFTDKADYDKIRERDLISVMGLKDFAPGRTLKVVLHHEDGSKESFEVQHTY
                     NEQQIAWFRAGSALNAR"
     CDS             complement(7452..7919)
                     /locus_tag="ctg64_11"
                     /transl_table=11
                     /translation="MVYDLTMLKTFYAAYSEKIERVRNVLRRPMTLAEKILYAHLYDGD
                     KVKNYRRGEDYVNFRPDRVAMQDATAQMALLQFMNAGREQVAVPSTVHCDHLIQAYKGA
                     KEDVATATKTNEEVYNFLRDVSSRYGIGFWQPGAGIIHQVVLXXXXHFRVE"
     CDS             8034..9062
                     /locus_tag="ctg64_12"
                     /transl_table=11
                     /translation="MITFATMKEQDSNSPIIHLQQQQVLLRMEYEYEKEEFKRQTENMG
                     VARKVKRGLCWYPATPGRSYYNSLNQLVIEITHTENTDIEHNFEFGRPVCFFRQSADGK
                     ITYMNFTATVSYADETRMVAIMPGAGAVMEVQETDNLGVQLYFDETSYRTMFEALEDTL
                     RSKGNRLAELRDILLGTSKAGFRELYPVRFPWLNSTQETAVNKVLCARDVAIVHGPPGT
                     GKTTTLVEAIYETLHREPQVLVCAQSNTAVDWISEKLVDRGVNVLRIGNPTRVNDKMLS
                     FTYERRFENHPLYPELWSIRKNLRELGSRARRGSYDEREGVRSRMSRLRDRIGNTNQCR
                     AF"
     CDS             9031..9939
                     /locus_tag="ctg64_13"
                     /transl_table=11
                     /translation="LEIQINAELFDGAHVIASTLVSSNHRLLNGRRFGTLFIDEAAQAL
                     EAACWIAIRKADRVVLAGDHCQLPPTIKCYEAARGGLERTLMEKVVSNKPAVVSLLKVQ
                     YRMHEEIMKFPSQWFYNGELEAAPEVRYRGILDWDTPIHWIDTSEMDFKEEFVGETFGR
                     INKAEADLLLSELKIYINRIGGNRILEEKIDIGIISPYKAQVQYLRSKIKADASLKPYR
                     SLFTVNTVDGFQGQERDVIFISLVRANEEGQIGFLNDLRRMNVAITRARMKLVILGEAE
                     TLKHHGFYRKLLEFIQNIGNQ"
     CDS             complement(10001..11044)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_14"
                     /sec_met_domain="IlvN (E-value: 6.9e-47, bitscore: 149.3,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 6.2e-41, bitscore: 130.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQLNFGGVIENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     ACNLRDNGFNVIVGQRPGKTYEKAVADGWVPGETLFGIEEACQKGTIIMCLLSDAAVMS
                     VWPTIKPYLTPGKALYFSHGFAITWNDRTGVVPPKDIDVIMVAPKGSGTSLRTMFLEGR
                     GLNSSYAVYQDATGKAFDKTIALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMT
                     PFHDAIKPVVQKLYASVKSGNEAQISIDSNSKPDYREKLNAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(11095..11847)
                     /locus_tag="ctg64_15"
                     /transl_table=11
                     /translation="MMSENNKIGTYKFVAEPFHVDFTGRLTMGVLGNHLLNCAGFHASD
                     RGFGIATLNEDNYTWVLSRLAVELDEMPYQYEDFSIQTWVENVYRLFTDRNFAIIDKEG
                     KKIGYARSVWAMISMNTRKPADLLALHSGSIVDYVCDEPCPIEKPSRIKVASKEPVAAL
                     VAKYSDIDINGHVNSIRYIEHILDLFPIEMYKEKRIRRFEMAYVAESYYGDELTLFMDD
                     AGEGVYDVEVKKNGSEVVCRSKVIFTEK"
     CDS             complement(11844..12404)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_16"
                     /sec_met_domain="ALS_ss_C (E-value: 1.1e-19, bitscore:
                     60.8, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKLYTIIVHSENFAGLLNQVTAVFTRRQINIESLNVSASSIKG
                     VHKYTITAWTDKDTIEKVTKQITKKIDVLQAHYFTDDEIYQHEIALYKITTPTLEEKPE
                     VSKVIRKYNARIVEVNAVFAIVEKNGMSEEITNLYEELRQLDCVLQFVRSGRVAITTSC
                     FERVNEYLADREAKYRQSKHQES"
     CDS             complement(12437..14188)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg64_17"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.5e-47, bitscore:
                     151.4, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MADNNKKSNFSSLSQGEGRGEALITGAEALMRSLEHQGVKTIFGY
                     PGGSIMPVFDALYDHRKELNHILVRHEQGATHAAQGFARVSGEVGVCLVTSGPGATNTI
                     TGIADAMIDSTPIVVIAGQVGTNFLGTDAFQEVDLVGITQPITKWSYQIRRAEDVAWAV
                     ARAFYVAKSGRPGPVVLDFAKNAQVEKTEYAPTKVDYVRSYLPVPEMEPEAIRKAAELI
                     NGAKRPLVLVGQGVELGEAQQELRAFIEKAGMPAGCTLLGLSALPTNHPLNKGMLGMHG
                     NLGPNINTNKCDVLIAVGMRFDDRVTGKLETYAKQAKIIHFDIDPAEIDKNVKTDVAVL
                     GDCKETLAAVTQLLEPANHQEWIDSFRQYEEVEEEKVIRPELHPAGKALSMGEVVRAVS
                     EATHNEAILVTDVGQNQMMSARYFKYSKERSIVTSGGLGTMGFGLPAAIGATFGRPDRT
                     VCVFMGDGGLQMNLQELGTIMEQKAPVKMILLNNNFLGNVRQWQAMFFNRRYSFTPMMN
                     PDYMKIASAYDIPARRVMTREELAKAIDEMIATDGPFLLEACVEEEGNVMPMTPPGGSV
                     NQMLLEC"
     CDS             complement(14280..14390)
                     /locus_tag="ctg64_18"
                     /transl_table=11
                     /translation="ARPMTPVTRNREVSKALKAYASMVSSADKGAVRLID"
ORIGIN
        1 tcctctccca cagttcttcc atctgtacat gccgggtgta cttctccgaa agagacttgg
       61 gacggcaact ggcattcaat gtccccgtac gtttaccggc atcctcatcc agcaataagc
      121 cgacagctgt tgcagctccc ttacggggag tacggatgaa aggcctgaaa agtatatctg
      181 tcagcgggtc aaaccacata tgcatggtaa tgatattggt agacacaatc cccgggtcgg
      241 ccgcattcac aacaatacct ttgtgcttga cacgactggc caagtcgatg gtgaacagag
      301 tcaatgccag cttcgtgttg ctatatatag gaatgcgcca aaagtccccc cttcttcccc
      361 ggaggaaaaa atccggaaag tcaagatgac cgatggcata cgtacaagat accatattca
      421 caatacggct cccctctccc atcaatggca gcagcttgcg agtcagcagg taaggcccta
      481 cataattgac actcaccgtc cgttccagtc cgtcctcggt aatgcggcgt tccgtttcca
      541 tggttccggc attgttcatc aacaacgcca acggctctcc ccgcttcaac agatgctctg
      601 caaatgcgac cactgaagcc agagatgcca aatcaatggg agcagtctca atacgcggat
      661 taccggtttc acgcatcagc agttgccgct tgggttcggc agcttggggg tcacggcatg
      721 ccatgatgac ctgatagccg gcagttgcca ctgcgcgggt aatttccatg cccatgccac
      781 cgtctgcccc agttataaca gctaaattca ctttaataat taaaaattga aaattaaaaa
      841 ctaaaaatca gcctttcgct tcgattttct ctatctcctt tttcagacaa ggtggaagtt
      901 cctccttcaa atgctgatgg catgccatct cgatggaata catccgggca atgcaataat
      961 tactatgccg gcagttgcaa cgtgcattct cttcggcacg catgcggttg acgaaccccg
     1021 gctcattgag cagagcgcgc gccatttgca cagcctcgaa gccgtcatcc agcacctcat
     1081 ctatcttgtc cctggaaacc aggccaccca cataaaccaa cggtatcttc aaggcggcac
     1141 ggaatttcaa ggcatcttcc aggaaataag cttccttaaa cggtacgctc ggtatcatcc
     1201 atttgcctac catgcgtaca ccgtatttca accaccagca ggtcatgtaa tgcgtcatgc
     1261 tgcggatagg catttcgccc cgcatgacat acatcggcgc cttactgacg aacccaccgc
     1321 tcaagaccag cgcatgtgct cccgactgct ccagcctccg ggccacctgc atcgtctcgt
     1381 ccagctccat ccctccacgg aaaccgtcgc gcatgttcat cttcaccagc acagccatat
     1441 cactgccggc agccttcatc acttcttcca tcaccatatc cataaaacgc atacggttct
     1501 gcaacgaacc tccgaactcg tctttccgat ggttggtgga cggggacaag aactggctga
     1561 tgagatagcc atgccctgca tgaatctcta cagaatcaaa tccggcctcc cgtgccagat
     1621 tcaccgaacg cccataagca cgcgccatct ctggcagctc atcggcacgc agtccgcgca
     1681 caaaggtagg agagtaaaga ttgaaaccgg aagatgcgcc gacgggcata caaccgcaaa
     1741 tgctcttatg ggacatgttg ccacagtgtc ccaactggat gcctgccgca gccccttccg
     1801 catgtatggc atcagtcagc ctacggagtc nnnnnnnnnn gacgcatcca caactggcgg
     1861 tcaaaagaca ggccgctctg agtaactgcc gcataggcaa cagtagtcat acctataccg
     1921 cccgccgcta ccgaccgatg atagtcgagc aacatgtccg acggagcgtt tccgggacac
     1981 atgctctcga aagcagccga acggatggta cggttacgca aggtcaacgg tccgaaagtg
     2041 acgggtgtga ataacttgga ttccatcgtt atgagttata agttatgaat tattcatttt
     2101 ccattttcaa ctctccattt tccattaata aagaaatgga atgatgcgtt tgcgctttcc
     2161 taccgcctca tcaccaaact cctcccgata acggcggtga atggcatcgg cacggggaac
     2221 aaggttggca aacgtccacc agacgaacac ccaggcggcg ggagaagctg tgagtatggc
     2281 aaaccccgtc cattccacca gctcaccgaa gtaattggca gaagtgacgt atcggtaaag
     2341 cccttttccg ggaagataat gcttcgtatc acccggcctg cgcagatgac gtatcacata
     2401 gtcggaatgc aaattgacga acatacccgc aaaaaacaga atgattccca acaaggcatg
     2461 aggtttcagc aaataggccc agccatcggc atacaagcct tcgggagcaa aatnnnnnnn
     2521 nnnnccgccc gcctgcatca tcccgttcaa aaggttgaag acgataccca tcgccataat
     2581 agctaccggc atccggcttt tacctttcag caggaacgga aaaataaagg cccgctgaag
     2641 atagtgcaac tgaaacagca ggaaaaagaa atataccggc acggcaaatc ccgctccact
     2701 cttcccccac aacccaaaca tgacgatgaa taccggcgct tccataagca cccacgccag
     2761 tttattattg atggagattc cccacgaggc agtacggaac atgccataac ccgctttgac
     2821 aaaatagagc gcaataaaga caaccaatgc cacagcactc attacccaca gaaatatctg
     2881 aaaagtttcc tgattcatag ttctttattt atgcgaagca aagataaaga aaactcacaa
     2941 caaacaaatc gttttccccg gataattgtt ttttcatgca aaaaacagtg tttttttact
     3001 gagaagatta agcagtagag atacaaaaat ctaatcgttc catcatggag taaatttcat
     3061 tccaccatgg agaaaaaatc gttccaccat ggtggaacga tttttccccc gtgatggaac
     3121 gatttaaaag atacaagtct aatccttacc gtttcttaat gggcacataa gtcacctcat
     3181 ccaaaacatt cttataggca ggacggataa tacgcttacc ttcaaagttc aattcttcat
     3241 tgcgatgtgc acaccaaccg acaatacgtg ccatagcaaa caaaggcgtg aagatttcct
     3301 gcggcagtcc aatcatctcg tagacaaagc ccgaatagaa atccacattg ctcgaaaccg
     3361 tctttccatt attcttcaca cggccaaaca catcaatggc gcgctcctcg agcagttcaa
     3421 ggaaagcgaa ctcacgttct ttcccttttt cgcgggcaag gtcgcgggca agctccttca
     3481 gcagaatggc gcgcgggtcg gaaatggtat agacggcatg tccgatacca tatatcaaac
     3541 cggtcttgtt atagacttcc ttgttgagca tgcgggtgaa gtaagtatca atctcatcca
     3601 cgttcgtcca gtcctgaatg ttttcctgca gatggtggaa catatcggca acctgaatat
     3661 tggcacctcc atgaagcggc cctttcaagg aaccgatacc tgccgctatc gaagagtaag
     3721 tatccgtccc ggtagaagaa gtgacacgta cggtaaaagt ggagttgtta ccaccaccgt
     3781 gctcggcctg aagaaccaac agcaggtcga gtgtgcgggc atccagctcc gtgtagtcct
     3841 tcttcagcat atagaggaaa ttctcggcaa tggaaaggtt ttcctgcgga tggcggatat
     3901 gcagtgaacg gccatgggtg gcatggcgaa gcatgttata ggcatacgca atgatggtcg
     3961 ggaatttcga aataagctca atgctctgcc gcatcagatt atcgcgggaa gtgtcatcgg
     4021 catccgggtc gaaacggtac atctcgagca cgctgcgcgc caggatgttc ataatgttgt
     4081 ttccttcaag ttcaatgata ttcatcttgg tcttctgctc cagcggcatg ttgtcgttga
     4141 tgagttcacg gaaagaagag agttcttcct tgtcgggcag gcgaccggaa agcaacaagt
     4201 aggcaatttc ctcaaaaccg aaacgcttct ctttgatgat ggcgtgtgcc aagtcatcca
     4261 catcataacc gcggtagaac aatttgccgg gaataggctt cagccctcca ccggggatgc
     4321 gttcatagcc gaccacattg cctattttgg tcaaccccac caagactccc gtgccgtcct
     4381 cattacgcaa accgcgcttc acatcaaact tcctaaacag ttcattctca atccgggtag
     4441 cttccttcaa atcttcggaa agcttgtaaa tcagatactc cttcttcata atcgtttcgt
     4501 tttattcgtt attcccattt tctattctcc ttacaatctc ccgggtgaaa gtcgaagtgg
     4561 acagcgagac gctacccggc ataaaacggg ccaagtcggc agtagcacgg gcttctgtga
     4621 aactttcctc caaggcgttc tctataagag aggctgcttc cttccagccc agatattcaa
     4681 gcatcatcac agcggaaagg atgatggaac agggattcac aatgtctttc ccggcaatgt
     4741 tcggagccgt cccgtgagta gcctcaaaaa tggcatgccc cgttttatag ttgatattcg
     4801 cacccggtgc aatgccgatg ccgcctacca tggcagccag ttggtcggac acataatcac
     4861 cgttcagatt caacgtggcg atcacggaat attcttcggg gataagcaac gtgttctgca
     4921 agaatgcatc ggcaatgcag tccttgatga ccagacgccc ttctgccagc tctttaccaa
     4981 actcacgttc tgccagttcg tacccccact tcttaaaacc gccttccgta aatttcatga
     5041 tgtttccttt gtgtaccaag gtcacggaag gcagatgatg ctcaagcgcg tatcggcagg
     5101 cggcacgcac caagcgctct gttccttctc ttgaaacggg cttcacgcca aacgaggagg
     5161 tttcgggaaa acggactttt gtcaccccca tgtcatcacg gagaaaacga tagaactttt
     5221 cagcctccgn nnnnnnnnnn nnncggcttc ccattcgatg cctgcataaa tatcctcggt
     5281 attctcacgg aatacgcaca tatccacctt ctgcggctct ttgagtggag aaacaatgcc
     5341 cttataccaa cgtaccggac gttggcagac atacaaatca agtgtctgac gcaaggctac
     5401 gttcaaggaa cggatacctc cgccgacggg agttgtcaaa ggacctttga tgcccacctt
     5461 ataggtgcgg aaggcttcca tggtttcgtc cggcaaccag gagccggttt cgtggaaagc
     5521 acgttctcct gccagcactt ctttccattc aatgccacgc cggtcgccat aggatttctt
     5581 gacagcggca ttcacgacag cctgcatgga tggggtcact tctgctccca ctccatcgcc
     5641 ggtaataaaa ggtacagtaa ttttttccat attctatctt gcattaagtg cagaaccggc
     5701 ccggaaccaa gctatctgct gttcgttata cgtatgttgt acttcaaaac tttctttact
     5761 cccatcctcg tgatgaagaa ccaccttcaa cgtgcgtccc ggagcaaaat ctttcagccc
     5821 catgacagaa atcaggtcgc gttcccgaat cttgtcataa tcggccttat ccgtaaaggt
     5881 cagcgccaac atgccttgtt tctttaagtt cgtctcatgg atacgggcaa aactcttcgc
     5941 caaaatgacg cgtacattca ggaagcgcgg ttccatggca gcatgctcac ggctggaacc
     6001 ttcaccataa ttctcttcgg caacgaccat ggaagggata ccttcggact tatacagctt
     6061 cgcagtgcct gacactgttc cataggtatt ggtggagcgg ttccaaacct tgttcgtctc
     6121 tccattgaaa gcattgacag cccccatcag catattgtcc gaaatattct ccaaatgtcc
     6181 ccggaaacgg agccatggcc ccgccatgga aatgtggtcg gtggtacatt tcccctgtac
     6241 tttaatcaat aaaggcatgt ccagcaaatc catgccatcc caggcaggga agggagtcag
     6301 cagttgcaag cgctgtgaat gaggattgac cgtaatttcc gtctgtcctt tgcctggagc
     6361 aatgtatcct tcctttcctc ctataaaccc gtgtgccggc aattcttcac cgaccggttc
     6421 ggacagtttc acaacctctc ctttggcatt gaccagcgta tccctcaacg ggtcgaaaca
     6481 aaggtcaccg gcaatggtca gcgccatcgt tatctccggg gaagcgacgt aagcaaaagt
     6541 gttgggattt ccatcggcac gtttggcaaa attacggtta aaagaggtga cgatggaatt
     6601 tttgcgttcg gggtcatcag tatggcgctt ccactggcca atacaaggtc cgcaggcatt
     6661 cgccattatc gttgcgccaa tatcttcgaa agcggcaatc atgccgtcgc gttcagcagt
     6721 ggcacgtatc tgctccgagc cggggttgac aatcagcgag gaagcaacct tcaaattctt
     6781 ttcctttacc tgccgggcaa gggaggccgc gcggctcaaa tcctgatagg acgaattggt
     6841 gcacgaccct atcagaccga cttccatccg gcggggatag ttattggtta tcactacctc
     6901 ggcaaatttc gatatcggtg ttgctgcatc cggcgtaaag ggcccgttga tatacggttc
     6961 caataacgag aggtctattt caatgatgcg gtcgtaatat ttttccggat ttgccagcac
     7021 ttcgtcgtcg gcgcgaaggt cggcagctac ggaagcagcc atttccgcca cttcttcacg
     7081 tccggtagct ttcaagtagg tacccatacg ctcatcgtaa gggaaaaggg aggtagtcgc
     7141 ccccacctct gcccccatat tgcagatggt agcctttcca gtggcagaca atgaagcggt
     7201 tcccggtcca aaatattcaa tgatggcatt ggttccccct tttacagtaa gaatacccgc
     7261 caacttcaga ataacgtctt tgggagctac ccagccactc aatttaccct tcaagtgtac
     7321 gcctatcaga cgcggctttt tcagttccca ttccatgccg gtcatcacat ccaccgcatc
     7381 ggcaccaccc acaccaatgg ccaccatgcc caaacctccg gcattgggcg tatgagagtc
     7441 cgtgcctacc atcattccac ccggaaatgc gnnnnnnnnn ncaataccac ctggtgaata
     7501 atacctgctc ccggctgcca aaaacctatg ccatagcggg aagaaacatc acggagaaaa
     7561 ttatagacct cctcgttggt cttcgtagca gtcgcaacat cttcttttgc acctttatat
     7621 gcttgaatca aatggtcaca atgcacagtg gaaggcacgg caacctgctc acggcctgca
     7681 ttcataaatt gcaataaggc catttgagcc gttgcatcct gcatggccac acggtcggga
     7741 cggaaattca catagtcttc tccccgtctg tagttcttca ctttatcccc atcatacaaa
     7801 tgagcataca aaattttctc cgctaaagtc atcggacgcc gcagtacgtt ccgtacgcgt
     7861 tctatcttct ccgaataagc agcataaaac gttttgagca tcgttaaatc atataccata
     7921 accactattt tttagttttt cattattgta aagattacaa attaatatca taaacaaata
     7981 aaaaggctga atagtttaac aaaataaagc attttttccg tcggaagcga agaatgatta
     8041 cctttgcaac catgaaggaa caagattcaa atagtcctat tattcacctc cagcagcaac
     8101 aagttttgct gcgcatggaa tacgaatacg aaaaagagga attcaaacgc caaaccgaaa
     8161 acatgggagt tgcccggaaa gtgaaacggg gactttgctg gtatcctgcc actccgggac
     8221 gaagttacta taattcactg aatcaattag taatagaaat tacacacaca gaaaataccg
     8281 atatagaaca taattttgag ttcggccgtc ccgtatgttt tttccgccag tctgctgatg
     8341 gaaaaataac ctatatgaac ttcaccgcta ccgtaagcta tgccgacgag acacggatgg
     8401 tagcgataat gcccggagcc ggtgccgtta tggaagtgca ggaaacggac aacctcggcg
     8461 tgcaacttta tttcgacgaa acatcctatc ggaccatgtt cgaagccttg gaagatacgt
     8521 tacgctccaa aggcaaccgc ctggccgaat tgcgggacat attgctggga acctcgaaag
     8581 ccggtttccg agagctctat cccgtacggt ttccctggct gaactccacg caggagacag
     8641 ctgtaaacaa agtgctgtgt gcccgcgacg tggccattgt acacggtcct ccgggaaccg
     8701 gaaaaacgac caccttagtg gaagccatct acgaaaccct gcatcgggaa ccgcaggtac
     8761 tggtatgtgc ccaaagcaat actgccgtcg actggatttc ggaaaaactt gtggaccgtg
     8821 gcgtcaatgt cctgcgtatc ggcaatccga cccgtgtcaa cgacaagatg ctttccttta
     8881 cctacgagcg tcgtttcgag aaccatccgc tttatccgga gctgtggagc atccggaaaa
     8941 atctccgtga actgggcagc cgtgcccgcc gtggcagcta tgacgaacgc gaaggagtac
     9001 gcagccgtat gagccgcctg cgcgaccgca ttggaaatac aaatcaatgc agagcttttt
     9061 gatggggcac atgtcatagc ctccacgcta gtaagcagca atcaccggct gctgaacgga
     9121 cgccgtttcg gcaccctttt cattgatgaa gcagcccagg ccttagaagc tgcctgctgg
     9181 atagctatcc gaaaagcaga ccgcgtggtg ttggcgggtg accactgcca acttccgccc
     9241 actataaaat gctacgaagc tgcccgtgga ggtctggaac gaacattgat ggagaaagtg
     9301 gtgtccaaca aacctgccgt tgtctctttg ctgaaagtac aataccgcat gcacgaggaa
     9361 atcatgaaat ttccttccca atggttttat aatggcgagt tggaagccgc tcccgaagtg
     9421 cgttaccggg gcatcctgga ctgggatacc cccatccact ggattgacac ctccgaaatg
     9481 gatttcaaag aagaatttgt gggagagact ttcggacgca ttaataaggc ggaagcggac
     9541 ctgctcctat cagaactgaa aatctacatc aaccgtatcg gtggcaaccg cattctggaa
     9601 gaaaaaatag acatcggcat catctcccct tacaaggcac aagtgcaata tctccgcagc
     9661 aagataaagg cagacgcttc actcaagcct tatcgcagct tgttcactgt aaatacggtg
     9721 gatggcttcc aagggcaaga gcgcgatgtt atcttcatca gccttgtccg tgccaacgaa
     9781 gaaggacaga taggattcct gaatgattta aggagaatga atgtagccat cacccgggca
     9841 cgtatgaagc tggtgatatt gggagaggca gagacgctga aacatcacgg tttttaccgg
     9901 aagctattgg agtttattca aaatataggg aatcaataat aaagaaatac cccctccggt
     9961 aacaccgaag agggtatttc acctatttat ataaagctga ttaattgttt tccggacgaa
    10021 gtttacgaac tgtaacagct gtctgccaca tttcgctttc acgcaaggct ttcaattctg
    10081 cattcagctt ctcacgataa tcgggtttgg agttactgtc gatagaaatc tgagcttcgt
    10141 tgcccgactt cacacttgca tacaatttct gtacaaccgg cttgatggca tcatggaacg
    10201 gggtcatcca atccagcgca ccacgctgtg ccgtagtaga acagttggca tacatccagt
    10261 ccataccgtt cttggcaaac aatggcatca aagattgagt caactcttcc actgtttcat
    10321 tgaatgcttc agaaggagta tggccgtttt cgcgcaatac ttcatactga gccaacagca
    10381 atccctggat agcacccatc aatgaaccgc gttcaccggt caagtcggaa gtggcttcgc
    10441 ggatgaaagt tgtctcgaac aaatatcccg aaccgatgcc gatacccagt gcaatcgtct
    10501 tgtcaaaagc cttacccgta gcatcctgat agacggcata tgatgagttc aagccacgac
    10561 cctcgaggaa catggtacga agtgaagtac cggaaccttt gggagcaacc ataataacat
    10621 caatatcttt aggaggaacc acgccggtac ggtcgttcca ggtaatagca aaaccatgag
    10681 agaagtaaag agcctttccg ggagtcaaat aaggtttgat agtcggccat acagacatta
    10741 cagctgcgtc agacaacaga cacatgatga tagtaccttt ctgacaagcc tcttcgatgc
    10801 cgaacaaagt ctcacccggt acccatccgt cagccacagc cttttcgtat gtcttacccg
    10861 gacgttgtcc tacaatcaca ttgaaaccgt tatcacgcaa gttgcaagcc tggcccgggc
    10921 cttgtacgcc ataaccgatt actgcaattg tttcatcttt caaaatctca cgtgcttttt
    10981 ccaaaggaaa ttcttcgcgg gtcattacat tctcaataac accgccaaaa ttcaattgtg
    11041 ccattttttg ttttaatttt tatttgtggc ttacgccaac gttgataaat ttatttattt
    11101 ctctgtaaat atcactttag agcgacagac cacttcgctg ccattctttt tcacctccac
    11161 atcgtaaacg ccctcaccgg catcatccat gaacaaagtc aactcatccc cataatagct
    11221 ttcggctaca tatgccattt caaaacgacg gatgcgcttc tccttataca tctctatcgg
    11281 gaacaaatca aggatatgct cgatgtaacg gatgctgttc acatgcccgt taatgtcaat
    11341 atcactgtat ttggctacca aagcagcaac cggttccttt gaggccacct ttatccgcga
    11401 aggtttttct atcgggcaag gctcatcgca aacataatct acaatgctgc cactatgaag
    11461 agccagcaaa tctgccggct tacgggtatt catgctaatc atcgcccaaa cggaacgtgc
    11521 atacccaatc ttcttaccct ccttatcgat gatagcgaaa ttacggtctg taaaaaggcg
    11581 atagacattc tccacccaag tctgaatgga gaaatcttcg tactgataag gcatttcatc
    11641 cagttcgaca gccagacggg acaataccca agtataattg tcctcgttta gagtcgcgat
    11701 gccaaaaccg cggtcgctgg catggaaacc cgcacaattc aacaaatggt tgcccaatac
    11761 tcccattgtc agccgtccgg taaagtcgac atgaaacggt tcggcaacaa acttgtaggt
    11821 acctatttta ttgttctcgc tcatcatgat tcctggtgtt tactttgacg atattttgct
    11881 tcacggtccg ccagatattc attgacacgc tcaaagcagc tggtcgtaat ggctacgcga
    11941 cccgaacgga cgaactgaag tacgcaatcc aactggcgca actcctcata aagattggtt
    12001 atttcctcac tcatgccatt cttctcaaca atggcaaata cagcattcac ctccacaata
    12061 cgggcattgt acttacggat tactttggac acctccggtt tttcttccag cgtaggggtc
    12121 gttattttat aaagggcaat ctcgtgctga tagatttcat catccgtgaa ataatgggct
    12181 tgcagcacat ctattttctt ggtaatctgc ttggtcacct tttcaatggt atccttatcc
    12241 gtccaagcgg taatggtata tttatgtacc cccttgatgg aggaggccga tacattcaaa
    12301 ctctcgatgt ttatctgccg gcgggtaaac acagccgtca cctgattcag caaaccggca
    12361 aagttttccg aatgaacaat gattgtatat agttttttat ccatagatag agtaaattct
    12421 ttaatttcgc atgacttcag cattccaaca acatctgatt gaccgaaccg cccggaggtg
    12481 tcatcggcat tacatttcct tcttcctcca cacaagcttc gagcaggaac ggtccgtcag
    12541 tcgctatcat ctcgtcaatc gcttttgcca gctcctcgcg ggtcattacc ctgcgtgcag
    12601 gaatatcata tgccgaagca atcttcatat aatccggatt catcatcgga gtaaacgaat
    12661 aacgacgatt gaagaacatc gcctgccatt gacgaacatt gcccaagaag ttattgttca
    12721 acagaatcat cttcaccgga gccttttgtt ccatgatggt acccagttcc tgcaggttca
    12781 tctgcaagcc gccgtctccc atgaatacgc ataccgtgcg gtccggacgt ccaaaagtgg
    12841 caccgatagc tgccggaagg ccgaagccca tagtacccag gccaccggaa gtaacaatgc
    12901 tacgttcctt gctgtatttg aaataacggg cggacatcat ctgattctgg ccgacatcag
    12961 tcaccaatat cgcctcgtta tgggtagcct cactcacagc acgcaccacc tcacccatgc
    13021 ttagcgcttt tcctgccgga tgtaattccg gacggattac cttttcctct tccacttcct
    13081 cgtattgccg gaaactgtca atccattcct gatggttggc gggttccagc aattgggtaa
    13141 cggcagccag tgtctctttg caatctccca ggacagcaac atcagtcttt acattcttat
    13201 ctatttcggc agggtcaata tcaaagtgga taatcttcgc ctgcttggca tatgtttcca
    13261 atttacccgt cacacggtca tcaaagcgca tgcctacggc gataaggaca tcacatttat
    13321 tggtattgat attgggcccc aggttaccgt gcataccaag cattcctttg ttcaacggat
    13381 ggttcgtagg taatgcggaa agtcccaata aagtgcatcc ggcaggcatt ccggctttct
    13441 caatgaaagc acgaagctct tgctgggctt ctcccagctc cacgccttgt ccaaccagca
    13501 ccaaaggccg tttcgcacca tttattaatt cagcagcctt ccgtatggcc tccggctcca
    13561 tttcgggaac gggaagatag ctacggacat agtccacctt agtaggcgca tattctgttt
    13621 tctccacttg ggcgttttta gcaaaatcca gcacgaccgg tcccggacgt ccgctctttg
    13681 ccacatagaa agcacgtgcc actgcccagg ccacatcttc tgcacgacga atctggtaac
    13741 tccatttcgt gataggctga gtaatgccta ccaagtccac ttcctgaaat gcatccgtac
    13801 ccaagaagtt cgtccctacc tggccggcaa tgacaacgat aggcgtactg tcaatcatgg
    13861 catctgcaat gcccgtgata gtattggtag cacccggtcc actggtaacc agacaaacgc
    13921 caacctcgcc tgatacacgt gcaaagcctt gtgccgcatg ggttgctcct tgttcatgac
    13981 gaaccaagat gtggttcaat tccttccgat ggtcgtataa ggcatcgaat accggcatga
    14041 tgctccctcc cggataaccg aaaatagtct ttactccctg atgctccaga gagcgcatca
    14101 atgcttctgc gcctgttatt agagcctcac cccgaccctc tccttgggag agggaggaaa
    14161 agttactctt tttattatta tcagccatac tttatctatt cattatattt aaaagctcaa
    14221 tagtagcttg aaaaatttgt ttcattctct cctcccctcg ctttcggaaa ggggggcttt
    14281 taatcaatca gcctcacagc ccctttgtca gcggaactca ccatactggc atatgctttc
    14341 aatgctttgg agacttcacg gttgcgggtt accggagtca tagggcgtgc
//
