LOCUS       c00109_gnlPro..        12887 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NEKOCHJB_109.
ACCESSION   c00109_gnlPro..
VERSION     c00109_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 12:54:58
            Original ID  :: gnl|Prokka|NEKOCHJB_109
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12887
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12887
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4862:9398]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      4863..9398
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12887
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12887
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(3..542)
                     /locus_tag="ctg109_1"
                     /transl_table=11
                     /translation="MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKET
                     FKDDAEPRPVSIAGRIMSRRIMGKASFMELQDSEGRIQVYISRDDICPDENKDTYNVVF
                     KKLLDIGDFVGIKGFVFRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFNDPE
                     LRYRQRYVDLVVNDGVK"
     CDS             complement(723..971)
                     /locus_tag="ctg109_2"
                     /transl_table=11
                     /translation="MNSLYMVEGVIGAVGGAIFVQTNKYLQAGMENEDFYGWGLEDGER
                     HYRWLSFGYRIYGVRAVYSICLIPGIKTGCKDKIIGS"
     CDS             complement(1452..2027)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_3"
                     /sec_met_domain="CTP_transf_like (E-value: 1.6e-25,
                     bitscore: 80.1, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLKIGIYSGSFNPIHIGHLALANWLCEFEGLNEVWFVVTPHNPL
                     KKKDDLLDDSLRLEMAQAAIDGYPKFKVCDIEFHLPKPSYSIDTLRALSSNYPDRDFYF
                     IMGADNWLLFPRWKEYEKILQNYKLLIYPRLGFDISIPTIYPNVKKVDAPLMEISSTFI
                     RNAYQTGKDIRFFLPEGVRPYFGSVANQ"
     CDS             complement(2039..2218)
                     /locus_tag="ctg109_4"
                     /transl_table=11
                     /translation="MPNIFKNTRFMMGLSIVCGIASLVLGGISLYYKEYIIGGALIFNI
                     FICFINYKGWQKKG"
     CDS             complement(2222..2788)
                     /locus_tag="ctg109_5"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTE
                     KNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYYGTLKSEVERILNEGDNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQFD
                     KVVVNDDLETAQKDALKIIREFLNK"
     CDS             complement(2803..3663)
                     /locus_tag="ctg109_6"
                     /transl_table=11
                     /translation="MTGFGKVTAELPSKKVTVEIKALNSKQLDLSTRIPSIYKDKEMEL
                     RSLLLQSLERGKVEFNIFIEYIGKDTPTQINLAAVENYYNQIKEIAEKLNISVPNDWFQ
                     TLLRMPDAIKSETVEPDESEWEVVLETVKDAIKHLCDFRIQEGAMLQKLFEQKIANIAT
                     LLKEVEKYEGERIEKIKARIMDNLQKIAEKDYDKNRFEQEMIYYIEKLDVNEEKNRLDN
                     HLKYFISTMESGHGQGKKLGFIAQEMGREINTLGSKSNHAEMQKIVVQMKDELEQIKEQ
                     VLNVL"
     CDS             3865..4581
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_7"
                     /sec_met_domain="Peptidase_M22 (E-value: 4.4e-28, bitscore:
                     88.7, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLILNIETSTSVCSVALSEGEEVVFEKASFEGPSHAALLGVYME
                     EALEAAKSKGIKLDAVAVSSGPGSYTGLRIGVSVAKGLCFGYGIPLIGIHTLDILASAA
                     IRKNKEEADCLYCAMLDARRMEVYSSIYDSHLNTIRATTADIVDADSYASFLENGKVCF
                     FGDGAAKCETVITSPNACFIDGIYPLAVNMASLSQKAYDDGRFENVAYFEPFYLKEFQA
                     TIAKNKVLNEALGKNK"
     CDS             4650..4796
                     /locus_tag="ctg109_8"
                     /transl_table=11
                     /translation="MRKKSVNTLLVFGVVVAIILLMIWLFLGTTLVEDTSTEISPVPIE
                     QAN"
     CDS             complement(4863..6023)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_9"
                     /sec_met_domain="OAD_beta (E-value: 8.4e-154, bitscore:
                     501.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLQFLGENIQIFLSYTGFANATPGHIVMLLVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQLGIYEEGSVLNILYQGVKQGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYIIALQMGFDPSQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERVIRMKPPRAVSQTEKIVFP
                     IVGLLLTAFLVPSGLPLLGMLFFGNLIKESGVTRRLAETARGPLIDVITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKFFNLFLKEGNKINPLIGNSGVSAVP
                     DAARISQNVGLEYDPSNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(6028..6459)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.7; E-value:
                     3.5e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_10"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.1e-21, bitscore:
                     63.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNTYKVHINSVVDDVAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTNASGEPVITRQAAPSVAGAVKSPLPGVILSVDCKVGDTVKRGQKILV
                     LEAMKMENNINADRDGKIVEIKVNKGDSVLEGADLVVIG"
     CDS             complement(6483..7376)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_11"
                     /sec_met_domain="OAD_gamma (E-value: 2.1e-13, bitscore:
                     40.9, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLLMVLFNMGAKAQLTTSVKLNEVLVVNEDNFVDDY
                     GKRHPWFELFNNSAGTVDLRGCFLTNDKSNPRKYMIPKGDVLTKVPPRQHLLFWADDQP
                     TKGTFHVNFTFDPNKDNYLALYDSDGTTLIDEVTIPAGQKADVSYGLDLDGVGNWSILD
                     KVTPSTNNLTLDSNAKLENFQRNDPWGIGMTITAMAVVFLGLIILYLVFKQIGNAAIKA
                     SKRNAQKAAGTGAAVSANIGQESGEIFAAIATALYEMSDDNHDIENTVLTIHKVQRSYS
                     PWSSKLYSLRQTPNKK"
     CDS             complement(7398..8951)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_12"
                     /sec_met_domain="CT_Btheta (E-value: 1.3e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             complement(8988..9398)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg109_13"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.6e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             complement(9527..11938)
                     /locus_tag="ctg109_14"
                     /transl_table=11
                     /translation="MKIRAIAALLFILISVSAFGEGRIKITGYVRDADGNPLELVNVRV
                     KNTLIGSMTNEKGYYSFSISPGDSISVIYSCLGYNKAERIIPSAQADMRLNVQMNNTSF
                     DLGEVSVTAIRKQTTTMESLNADKIKLLPDPSGGSIESLVVTFAGVSSNNELSSQYSVR
                     GGSYDENIVYVNGIEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSV
                     LDITYKKPKIFEGSASASLLGANAYVGSSIGKFTQVTGFRFKSGRSILGTMDTDAEYDP
                     KFIDLQTYITYQLAPKWEINFLGNLANNNYKFTPYSRETSFGTAEHPKNFKVYFDGRER
                     DRFQTLFGALTLKDNPNENTELGLQASAFKSKEEEGYDIAGEYWLSENGAENPDDDASA
                     AMSVGRYHEHARNRLNSTVMNVGHYGMARLLNNTLKWGATVQMEKINDKISEWEKRDSS
                     GYSLPQTGNNVSVYSNLFSDNQIESTRFSAYAQDAFKFRTKQGLFTLVAGVRGSYWTYN
                     KEFLFSPRASLGFIPNFDQDLTLRFATGLYYQSPFYKELRRVDKDKNGNNITVLNKDLK
                     SQRSIHFILGGDYTFRAVDRNFKVTAEMYYKKLDNLNPYTVDNVKIRYYGENCAKGYAM
                     GLDVKFFGEFVPGTDSWISFSLMKAQQTIRETTTVPMANSQGYNISLFFQDYFPGYKRV
                     KLNLKGVLSGGLPQTIPGKGYEAGYFRTPAYKRVDIGLSYQLAGGTDAIMDRGFFRHLK
                     NIWLGLDVFNILDIKNVSSYYWITDVYNVQYAVPNYLTGRQLNVRLIVDF"
     CDS             12060..12620
                     /locus_tag="ctg109_15"
                     /transl_table=11
                     /translation="MESFATLIQNRRSTRKFTEQLLSPEQVELILKAALMAPASKRSNP
                     WQFVVVEDKEMLKKLAGCKKNGSAFLEGCALAVVVLANVMESDVWIEDASVASIYMQLQ
                     AEDLGLGSCWCQIRNRVTEDEVDSNNYVRSLLDIPYQLDVLSIIGIGYKDQVRKPFDES
                     HLQWEKIHIGKFSLPEENKETGE"
     CDS             12617..12886
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg109_16"
                     /sec_met_domain="F420_oxidored (E-value: 8.3e-11, bitscore:
                     32.6, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVVFVGAGNLATRLSLEMRKSGMSIGQVYSHTSEHAKILADELG
                     CGWTVIPEEIVEDADLYVFSLKDAVLQDVIARVKPNNGLWVHTAG"
ORIGIN
        1 tcttttacgc catcgtttac taccaaatcg acgtaacgtt gacggtagcg aagctccggg
       61 tcattaaaac cgtcgtaagc gacaccgtcc ttatatttaa cgaccggtag cggacgaagt
      121 gatttagaca aaactgtcaa ttcttgagca tgaacggaaa tttctcccat ctgagtacgg
      181 aaaacgaatc ccttgatccc gacgaaatca ccgatatcca gtaatttctt gaaaacgaca
      241 ttgtaggtgt ccttattctc atccggacaa atatcgtcac gggagatata gacctgtatt
      301 ctgccctcgg aatcctgcaa ttccatgaag gaagccttac ccatgatacg acggctcatg
      361 atacggccgg cgatacttac cgggcgtggc tcagcgtcgt ctttgaatgt ctcttttatt
      421 tctttggaaa atgcgttcgt tacatactca gctgcgggat aaggctctat ccccatctga
      481 cgcaactgct ccatgctatt acgtcttatt atttcctgtt cactcagttc taatagattc
      541 attatgctat tattttgtat aatacggcgc aaaagtacaa aatatttctg atttatgctg
      601 acttatgtgg taaaaggttg aggtcaccga tcttgtttgt tcatggataa agtatcttag
      661 gttcatcggt aaagtatctt aggatccttg gtgaagtatc ttaggtttgt aggctaatga
      721 acttaagacc caataatttt atctttacat cccgttttga tcccggggat gagacaaatg
      781 gaataaacag ccctcactcc gtaaatccgg tagccaaaac tcaaccaacg gtaatgtctt
      841 tctccgtcct ccaagcccca gccatagaaa tcctcatttt ccatacccgc ttgcagatat
      901 ttgttcgttt ggacaaaaat cgctcctccg actgccccaa taactccttc caccatatac
      961 aaagagttca tttttctttg gtgttttttt taggaagtca atgtctctat gtggccagta
     1021 atgttccctc aatatatttg aagtgtccaa agcattccca tcgtatggat aagctacctc
     1081 gtatgtctta gatcttgtca agtctattcg cataaatatc tttgcttaat gttcaacaat
     1141 gccaatatca caccggggaa accattcagt aatcctcggt gtaaccatta gttattcact
     1201 tgacaaggct caaattatat atttggatac tccaaaaaga ttatcgggtg agcctgtttt
     1261 gatgttacgg ggatcatctt taacggctgt gctgtaaaac atgttttaat gggaattttg
     1321 gcagattgcc ctaagatggc aaagctgtaa ataatcacgg tataacttcc cttctcgaag
     1381 aatatatact tcaagtggca taggatatat acttcataac ccaagtaagt atatcttcta
     1441 tcgcaggtat gtcactgatt tgctactgac ccgaaataag gccgcactcc ttccggcagg
     1501 aagaaacgga tatccttgcc ggtttggtaa gcgttacgga taaatgtgga ggagatttcc
     1561 atcaagggag cgtctacctt tttcacgttc ggataaatgg ttgggatcga gatatcgaat
     1621 cctaggcggg gataaatcag cagtttgtag ttttggagta ttttttcata ttctttccat
     1681 cggggaaaaa gcagccagtt atcggctccc atgataaaat aaaagtccct atccggatag
     1741 ttgctggata aggctcgcaa ggtatcaatg gaataagaag gtttcggcag gtggaactca
     1801 atatcgcaga ccttgaattt cggatatccg tcaatggcgg cttgggccat ttccaaccgt
     1861 agtgagtcat ctagcaagtc atcctttttc ttcagcggat tatgaggcgt gaccacgaac
     1921 cacacctcat tcagtccctc gaactcacat agccagttcg ccaaggcgag atggcctatg
     1981 tgaatgggat tgaacgatcc actgtagatg ccgatcttga gtctcatccg atttatactt
     2041 accccttctt ttgccaaccc ttatagttga taaaacaaat gaatatatta aatatcaggg
     2101 cacccccgat gatatactcc ttataataca ggctgatacc acctaatacg aggctcgcta
     2161 tcccacaaac gatagaaagc cccatcataa aacgggtatt cttgaatata ttaggcatag
     2221 actatttgtt taagaactca cgaatgatct tcaacgcgtc tttttgggca gtctccagat
     2281 catcgtttac gacaacctta tcaaactgtc ccgtgaaccc taattcatac tcagccttgg
     2341 cgatacggct ttcgataact tccgggctgt ctgttccccg tccttccaat cgcttccgta
     2401 ggtcatcgat gcaaggaggt tggataaaga cagacagggc acggtctcca tagaatttct
     2461 tgatattgca tccgcctacc acatccacat cgaaaatcac gttgtcccct tcattcaaga
     2521 tacgctctac ctcgcttttt aacgtaccgt aatatttatc ggtatacacc tcctcatatt
     2581 ccaagaagtc tccattagcg atacgactgc ggaactcttc cggcgtaagg aaataatatt
     2641 ccacaccatt cttctcggtt ccccgcggag cccggctggt agccgagatg gagaaacgaa
     2701 ggtgtaaatc ttgtttcaaa agataattaa taatggttga ttttccggaa cccgagggtg
     2761 cggagaagat aattaatttg ccagccattc tcgttaatct tattataata cgtttagtac
     2821 ctgttccttg atttgttcca actcgtcttt catctggacc acgatcttct gcatctcggc
     2881 gtggttgctc tttgatccga gcgtattgat ctcacgcccc atttcctgag cgataaaacc
     2941 gagcttcttg ccttggccgt gaccggattc catggttgag ataaaatatt tcaagtggtt
     3001 gtccagacgg ttcttttcct cgttgacatc cagcttctct atgtaataga tcatctcctg
     3061 ctcgaaacga ttcttgtcgt agtccttctc ggctatcttt tgcaggttat ccatgatacg
     3121 agccttgatc ttctcgatac gttccccctc gtatttctcc acttctttca acagagtggc
     3181 gatattggct atcttttgct cgaaaagctt ttgaagcatg gctccttctt ggatacggaa
     3241 atcacacagg tgcttgatag cgtcctttac cgtttctaaa accacctccc attcggattc
     3301 gtccggttct acggtctcag acttgattgc gtccggcatc cggagcaagg tctggaacca
     3361 atcgttcgga acgctgatat tcagtttctc tgcgatctcc ttgatttggt tgtaataatt
     3421 ctctacggcg gcaagattga tctgtgtagg agtatctttg cctatatatt ctataaagat
     3481 attgaactca acttttcccc gctccaaaga ttgaagtaac aggctccgaa gctccatttc
     3541 cttatccttg tatatggaag ggatacgggt ggacaaatcc aattgcttac tgtttaaagc
     3601 ctttatctct acggttactt tttttgaagg gagctcggca gtaaccttac cgaacccagt
     3661 cattgattgt atcatttttc tcaaaagttt gcgcaaagat agtggtttcc ttttagattt
     3721 gatgtttatt ttctcataaa tagatgtttc tcatagggct gccttgatag cataatgaat
     3781 ttttgtatac cttcgcagcc taatcagatt gaaggattga gattgtttgt tcgttcaatt
     3841 atcaattgtt aatagttaat tattatgtca ttgatcttaa atatcgagac atccacttcc
     3901 gtatgttcag tagccctgtc ggaaggggag gaggtggtct ttgagaaggc ttccttcgag
     3961 gggccgtctc atgcggcgtt attgggcgtt tatatggaag aggcattaga agctgcgaag
     4021 tcgaaaggga taaaactgga tgctgtggcg gtaagtagcg gacccggatc ttatacgggg
     4081 ttacgcatcg gggtgtctgt ggctaaagga ttatgctttg ggtatggtat tcctttgatc
     4141 ggtattcata cgctggatat tttagcgtct gccgctattc ggaaaaataa ggaggaggcc
     4201 gattgcttgt attgcgctat gttggatgcc cgtcgtatgg aagtctactc ttcgatttat
     4261 gattcccatc tcaacacgat acgtgccacg actgctgata tcgtagatgc tgattcgtat
     4321 gcttcttttt tagagaacgg taaggtttgt ttctttggag acggtgccgc taaatgtgag
     4381 acggtaatca cttctccgaa cgcctgtttt atagatggta tctatccatt agctgtaaat
     4441 atggcatcct tgtcgcagaa agcatatgat gatggccgtt ttgagaatgt ggcttatttt
     4501 gagcctttct atttgaaaga attccaagca acgatcgcta agaacaaagt gctgaacgag
     4561 gcgttaggga aaaacaaata agagtaagag tacacaacca aattcatgtt ccggctgttt
     4621 attctaaaat gaataaatca gttaaagaca tgagaaagaa aagtgtgaat acgctattgg
     4681 tatttggtgt ggttgtcgct ataatccttt tgatgatctg gttgttcctc gggacaacgt
     4741 tggtggagga tacgagtacg gagattagtc cggttcctat agagcaagct aactgagaac
     4801 aataacataa aaaggcggga tcctttcgga cctcgccttt tttaatatag atagttgttt
     4861 tattaaccaa ggaatcctag caagataccg gcagctacag cggaaccgat tacacctgct
     4921 acgtttggac ccatagcgtg catcaacaag tagttgcttg gatcgtattc caaacctacg
     4981 ttctgggaaa tacgggcagc gtcaggtacg gcggatacac cggagttacc gatcaacgga
     5041 ttgatcttgt tgccttcttt caagaacagg ttaaagaact taacgaacaa tacaccggca
     5101 caagtagcga taacgaatga caacgcaccc aaaccgaaaa tcttgataga gttcaatgtt
     5161 aagaactggg tagcttgtgt agaagcacct accgtgatgc ctaacaagat cgtaataaca
     5221 tcgatcagcg ggccgcgggc tgtctctgcc aaacggcgag taacaccact ttccttgatc
     5281 aagttaccga agaacaacat tcctaacaat ggcaaaccag acggtaccaa gaaggctgtc
     5341 aatagcaagc caacgatcgg gaaaacgatt ttctccgtct gtgaaacggc tcttggaggt
     5401 ttcatacgta tcacacgttc tttcttcgtt gtaagcaatc tcataaacgg tggctggata
     5461 ataggaacca atgccatata tgagtatgcg gatacagcga tagcacccat caagttagga
     5521 gctaacttgg atgacaagaa gattgcggtt ggaccatcag ctcctccgat aataccgata
     5581 gcaccggctt ggctcgggtc aaatcccatt tgcaatgcaa tgatataagc accgaaaata
     5641 ccaaattggg cggcagctcc gactagcatt aacttaggat tggatatcaa agcggagaag
     5701 tctgtcatgg caccgatacc gaggaatatc aaggggggat accaaccttg tttcactcct
     5761 tggtataaaa tgttcaatac agaaccctct tcgtatatac ctaattgtaa tccggcatcc
     5821 ttgaaaggga tatttccgat caagataccg aaaccaatag ggatcagaag cattggctcg
     5881 aattcatatt taatcgctag gaatatgaac agcaaaccta ccaatagcat cacgatatgc
     5941 cctggagtcg cgttcgcaaa tcctgtatag gagagaaata tttggatatt ttctcctagg
     6001 aattgtaaga aactttcttg catatcatta accgattaca acgagatctg caccttccaa
     6061 tacagagtcg cctttgttta ctttaatttc tacaatttta ccgtcacgat cggcattgat
     6121 gttgttttcc atcttcatgg cttccaatac caagatcttt tggcctctct taactgtatc
     6181 gccgacttta cagtctacac ttaaaattac acctggcagc ggagatttaa cagcgccggc
     6241 tacacttgga gctgcttgac gggtgataac aggttcaccg ctggcattgg tcggagcttg
     6301 agccggacgt ttcaatgtaa ccatttgttt tttcgcaggt ttctccattt ttacgttata
     6361 aggggttccg tttacctcta cctctgccac atcatctaca actgagttga tatgtacttt
     6421 atatgtgtta ccgttaatgg tatatttaaa acttttcatt cgtcaattgg attttaggat
     6481 gattactttt tatttggagt ctgacgcaga gaataaagct tagaactcca tggtgaatag
     6541 ctgcgttgaa ccttgtggat agtcaatacc gtgttctcga tatcgtggtt gtcatcgctc
     6601 atctcataaa gagcggtagc gatagcggca aaaatttcac ctgattcttg accgatattg
     6661 gctgatacgg cagcacctgt tcctgcggct ttttgagcgt tacgcttgct agctttgatc
     6721 gctgcgttac cgatctgctt gaatactaga tacaaaatga ttaagccaag gaatacgact
     6781 gccatggctg ttatggtcat accaataccc catgggtcgt tccgttggaa gttctcaagt
     6841 ttcgcattcg aatctaacgt cagattattg gtgctaggag tcactttgtc aaggatactc
     6901 caatttccta ctccatcaag atccagaccg taactaacat ctgctttttg cccggcaggg
     6961 attgtcacct cgtcgatcaa agttgtacca tctgaatcat ataaggctag ataattatct
     7021 ttgtttggat cgaatgtgaa gtttacatga aatgtccctt ttgttggctg atcatctgcc
     7081 caaaaaagaa gatgctggcg gggaggaact ttggtaagta catctccctt cgggatcata
     7141 tattttctgg gattactttt atcgttcgtt aagaagcatc ctcgtaaatc caccgtacct
     7201 gctgagttat taaataactc aaaccatgga tggcgttttc catagtcatc aacaaagtta
     7261 tcttcattga caactagcac ttcatttaat ttaacggagg tagtcaactg tgccttggct
     7321 cccatattga agagaaccat taacagtagc aataccccta ttttcttatt tatcatattc
     7381 atctcctgtt ttacggatta tagaggcagg ttatcatgtt tcttagcagg attgcttaac
     7441 ttcttagtct gcaattgctg caaagcacga ataatacgga aacgagtgtt acgcggttcg
     7501 ataacatcgt cgatataacc gtattgagct gcgttataag gattagcgaa tgctttctta
     7561 tattcagctt ctttctctgc tgcgcatgct ttcggatctt cagcggctgc tacttccttg
     7621 gcgaagataa cctctacggc accgctcggg cccataacgg cgatctcggc tgtcggccat
     7681 gcgtaattca tatcaccacg taaatgttta gaactcatca cgcaataagc tccaccgtaa
     7741 gacttacgca atgtaacggt aatcttagga acggtagcct caccataagc gtaaagcaat
     7801 ttagcgccat gaaggattac accgttgtat tcctgacctg tacccggaag gaatcccgga
     7861 acgtcaacca atgttaccaa aggaatattg aaagcgtcgc agaaacgaac gaagcgacct
     7921 gctttacgag atgcgttgct atccaagcat cctgccataa ccttcggctg gttagctacg
     7981 ataccgacgg attgtccgtt gaaacgagcg aaacctacga tgatattctt agcgtagtcc
     8041 gcatggacct ctaggaactc gttgttatcg acgatcgtac cgataacctc atacatatcg
     8101 taagattggt tggcgttatc gggaatgata tcgttcaata catcatccag acgatcgatc
     8161 gggtctttgc actcaactaa cggcgtttcc tctaagttgt tctgaggtaa gaaactgagc
     8221 aatttacgga tcaattgcaa accatcttct tctgtatcga cagcgaaatg ggctacaccc
     8281 gatttggtag tgtgtacgct ggctccaccc aactgctctt gggttacatc ctcacctgtt
     8341 acggttttta cgactttcgg accagtcaag aacatatagc tggtaccacg tgtcatgatg
     8401 ttgaagtctg tcaaagccgg agaataaacg gctccaccgg cgcaagggcc gaagataccg
     8461 gaaatctggg gaacaacacc ggaagccaag atgttacgtt ggaaaatctc tgcgtatcct
     8521 gccaaggcgt ttacaccttc ttggatacga gctccaccgg agtcgttcaa accgataacg
     8581 ggagcgccca tcttcatggc ttgatccatt actttacaga tcttcatagc caaagcctca
     8641 gacaaggctc caccgaatac ggtgaaatct tgagcgaaga tatataccaa acgtccgtcg
     8701 atcgtaccat aacctgttac gataccatcg cctaaatatt tagttttctc gataccgaag
     8761 tttgtacaac ggtgttgaac aaacatgtcg aattcctcga aactaccttc gtcaagcaac
     8821 atggcgatac gctcacgagc ggtatatttg ccttttttgt gctgtgattc gattcttttc
     8881 tctcctccac ccaagcgagc ttgctcacga agtgcgatga gctcttttac tttttcaagc
     8941 tggttactca ttgtattttg atttgttgtt agaaatgaac ggattaatta tttgttgccc
     9001 ggcatgcaaa gctctgtcaa tacgctgcaa gttgatttcg ggtgaaggaa agcgatgttc
     9061 aagccttccg cgccaccacg gggagcttta tcgattaatt taacgccttt ttcctcagcc
     9121 tcgttcaaag ctgcctgtac atcaggtacc gcgaatgcga tatggtggat accttcacct
     9181 tttttctcga taaattttgc gatcgtgcta tcttcgctgg tcggctctag taattcaatc
     9241 ttagtctgtc ctaccttgaa aaatgcggtt tttacttttt ggtctgctac tacttcgata
     9301 ttgtagcatt ttaatccaag aacgccttca taatagggta aacaagcctc gatactcttc
     9361 actgcgatac ctaaatgttc gatatgtgta agttccatgt caataataat ttaaagattt
     9421 agtaaatgtt tgtttctatt gtgtgcaaat gtacactact ttttatgaat gaggaaataa
     9481 ttttttgttt ttatctccca gtaaatgtgt ttaaagatac attttattaa aaatcgacaa
     9541 tcagacgaac gttcaattga cgtccggtca gatagtttgg aactgcgtat tggacattat
     9601 atacatctgt tatccaatag taggaactaa cgtttttgat gtctaatatg ttaaatacat
     9661 ccagacctag ccaaatgttt ttcaaatggc ggaagaagcc cctgtccatg atagcgtccg
     9721 tgcctcctgc caattgatag gagaggccga tatctacacg tttgtaggcg ggcgtacgga
     9781 aatagccggc ttcgtatcct ttgcccggga ttgtctgggg aagtcctccg gatagaactc
     9841 ctttcagatt tagcttgact cgtttatagc ccgggaaata atcttggaag aagagtgaga
     9901 tgttgtagcc ttggctattg gccataggaa cggtcgttgt ttcccggatg gtttgctggg
     9961 ctttcatcaa ggagaagctg atccatgagt cggtacccgg tacgaattct ccgaagaatt
    10021 tgacatcgag tcccatggcg taacctttgg cgcagttctc gccgtaatag cggatcttga
    10081 cgttatctac ggtgtaggga ttcagattgt ccagcttttt atagtacatc tcggcggtca
    10141 ccttgaaatt ccggtctacg gcacggaacg tataatctcc tcccaatatg aaatggatgg
    10201 agcgttgtga ctttagatct ttgttcaata ccgtgatatt attgccgttc ttatctttgt
    10261 ctactctacg taattccttg tagaagggcg attgataata cagtccggtg gcgaaacgga
    10321 gcgtcaagtc ttggtcgaag ttcgggataa agcccaatga ggcacgggga ctgaaaagga
    10381 actccttatt ataagtccaa taactacctc taacccctgc gactaacgtg aacagacctt
    10441 gcttggtcct gaatttgaac gcgtcttgcg cataagcgga aaagcgtgtg ctttctatct
    10501 gattatcaga aaagaggttc gaatatacac ttacgttatt accggtttgg ggcaaagaat
    10561 aacctgagga atcccttttt tcccattcac tgatcttatc attgattttc tccatttgta
    10621 ccgtggctcc ccatttcaac gtattgttta aaaggcgggc catcccatag tgcccgacat
    10681 tcatgacggt ggagttcaaa cggtttcgtg cgtgctcgtg ataacggcct acggacatgg
    10741 cggctgacgc gtcgtcatcc ggattttccg ctccgttctc gcttagccaa tattctccgg
    10801 cgatatcgta tccctcttct tccttgcttt tgaaagcgga ggcttgaagt cccaactctg
    10861 tgttctcatt ggggttgtct ttcaatgtaa gcgcaccgaa taaggtttgg aaacggtctc
    10921 tttcccttcc gtcgaaatag actttgaagt tcttgggatg ctcggctgta ccgaaagagg
    10981 tttcccggct ataaggggtg aatttataat tattgttagc gaggtttccc aagaaattga
    11041 tttcccattt aggggccaat tggtacgtga tgtaagtttg cagatcgata aatttagggt
    11101 cgtattctgc gtctgtatcc atggtaccca aaatagaccg accgctttta aagcggaaac
    11161 ccgttacttg ggtaaattta ccgatagaac tgcctacata agcattcgcg cccaacaagc
    11221 ttgcggaagc cgagccttcg aatatcttag gctttttata ggtaatatcc agcacggaac
    11281 tcatcttgtc tccgtaacga gcctcgaagc caccggcggc gaaattgacc gcctccgtca
    11341 ggtccggatt gataaagcta aggccctctt gttgtcccga gcgaatcaga agcggacgga
    11401 atacctcgat cccattcaca taaacgatat tttcatcata actacctcca cgtacggaat
    11461 actgggaact taactcgtta ttggacgata ctccggcaaa cgtaacgacc aagctctcta
    11521 tactacctcc ggagggatcg ggcaataact taattttgtc cgcatttagg gactccatgg
    11581 tcgtggtctg cttgcggatg gcagtaacgg atacttcccc taaatcaaat gaggtattgt
    11641 tcatctgtac gttcaggcgc atatccgctt gtgccgaggg aatgatacgc tcagccttat
    11701 tatatcccag acaagagtaa ataacggaga tagaatcccc cggcgatatg gaaaaggaat
    11761 aatatccctt ctcgttggtc atggagccga tcaacgtgtt cttaacccgg acattcacta
    11821 attccagagg gttaccgtcg gcgtcacgga cataaccagt gatttttatg cggccctcgc
    11881 caaaggcact cacggaaata agtataaata gcagcgcagc tatcgcacga atcttcataa
    11941 tctattgttc aattataaaa atactaacga gaaaaaagaa cgatacgtat atatgggtgc
    12001 aaaaaattat atttatattt gcgaatctta atattaaaag agtacaaaga acgaaaaaaa
    12061 tggagagttt tgcaacactt atacaaaata gaagaagtac acgtaagttt accgaacaac
    12121 tactttcacc cgagcaggta gaactgatct tgaaggcggc gttgatggct ccggcctcaa
    12181 aacgtagtaa tccttggcag ttcgtggtcg tggaagataa ggaaatgttg aagaaacttg
    12241 ccgggtgtaa gaaaaatggt tccgcttttc tggagggttg tgccttggcc gtggttgtct
    12301 tggcgaatgt gatggaaagc gatgtttgga tcgaggacgc ttcggtcgct tctatttata
    12361 tgcaattgca agcggaggat ttgggactgg gcagttgctg gtgtcagatc cggaaccggg
    12421 taacagagga cgaggtggat tcgaataatt atgttcgttc gttgctggat atcccttatc
    12481 aattggatgt cttgtctatc attggtatcg gttataagga tcaggttcgt aagccttttg
    12541 atgaatccca tttacaatgg gagaagatac atataggaaa gttctctctt ccggaagaaa
    12601 ataaagagac gggagaatga gagtcgtatt tgttggtgcc ggaaacttag ctacccggct
    12661 ttcgttggaa atgcgtaagt ccggaatgag tatcgggcaa gtatatagtc acacaagtga
    12721 gcatgctaag attttagctg atgaattggg atgtgggtgg accgtgatcc cggaagagat
    12781 tgtggaagat gccgacttgt atgttttctc tttgaaagat gccgtgctcc aagatgttat
    12841 cgcccgtgta aaaccgaata acggtttgtg ggtgcatacg gcaggga
//
