LOCUS       c00026_gnlPro..        12289 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ILMKIDCG_26.
ACCESSION   c00026_gnlPro..
VERSION     c00026_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 07:52:46
            Original ID  :: gnl|Prokka|ILMKIDCG_26
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12289
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12289
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2576:7104]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2577..7104
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12289
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12289
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             2..2221
                     /locus_tag="ctg26_1"
                     /transl_table=11
                     /translation="LFILVSISAFGQKHVKITGYVRDADGSPLELVLVQIKNTLNGAMT
                     NEKGYYSISTSPGDSVAVIFSCLGYNKAERILPSLQQDMRLNVQMNYTSIDLGEVVAVG
                     TRYQTSTLQTMNADRVKLLPDPAGGSIESLVVTFAGVSSSNELSSQYSVRGGSYDENIV
                     YVNGLEVFRPLLIRSGQQEGLSFINPDLTEAVNFAAGGFEARYGDKMSSVLDITYKKPK
                     LFEGSASASLLGANAYVGSSIGKFTQITGVRYKTGRSLLKTMDTDAEYQPDFVDLQSYM
                     TYQLAPKWEVNFLGNLASNTFKFTPHKRETNFGTVENAQRFEVYFPNSRERDKFQTIFG
                     ALTLKHNPNEKTELGLQASAFSSKEIETYDITGEYWLGDATTENDNNQNALEIARYHEH
                     ARNRLSSTIMNVGHYGSSKIKNNTLKWGATVQMEKINDRISEWEKRDSAGYSLPQTGNG
                     VNVISNLYSDNDLSTTRISGYLQDVFKFRTKQGMFTLIGGIRGSYWSYNKEFIFSPRVS
                     LGFIPNFDQNLTFRAATGIYYQSPFYKELRTTVQDAAGNDIIELNKDIKSQRSIHFILG
                     GDYTFRAADRNFKVSADLYYKKLDDLIPYTVDNVKIRYYGENCAKGHAMGIDVKFFGEF
                     VPGTDSWISFSLMKAEQTIRDMVTVPMPNSQGYNVSLFFQDYFPGYKRVKLNLKGVLSG
                     GLPFIAPRTKYVLSARRPTNVSTSVSLTSWPEEPMRSWTAESFVT"
     CDS             complement(2029..2451)
                     /locus_tag="ctg26_2"
                     /transl_table=11
                     /translation="MKALTSHWQILFFIGILANYLIGIFLEIDNQSCIELSACQVIRYS
                     ILLVVDVGDPVIGTDIFYIEQVKYVHSDPDIFQVTKDSAVHDRIGSSGQLVRETEVDTF
                     VGRRAESTYFVRGAIKGSPPERTPFRFSFTRLYPGK"
     CDS             2577..2987
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_3"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.1e-27, bitscore:
                     86.3, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEITHIEHLGIAVKSIEACLPYYEEILGMKCYNIEEVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALDEAESKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGKK"
     CDS             3025..4578
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_4"
                     /sec_met_domain="CT_Btheta (E-value: 1.3e-292, bitscore:
                     960.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKFLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     ESLAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEEGLQLIRKLLSFLPQNNLEETPLIECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIIGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAASEDPAKATA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             4601..5485
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_5"
                     /sec_met_domain="OAD_gamma (E-value: 1.7e-12, bitscore:
                     37.7, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNKRFGVLLLFILLVSFGAQAQRATSMRINEVLVINEDNFVDDY
                     GKRHGWIELFNTSAGTVNIAGCFLTDDKNNPKKYPIPKGDVLTQIPPHQHTLFWADGEP
                     NRGTFHVNFTLDPSKENYIALYDADGKSLIDEITIPAAQKPDVSYGRIIDGKEEWAQLT
                     KVTPSTNNLTLDSNEKIENFKTNDSLGIGMTITAMAVVFLGLLLLFLIFKQVGKAAIAA
                     SKRNAQKAGAPVNVNTPDEVSGEVFAAIATALYEMSDDNHDIEHTVLTIRKVRRAYSPW
                     SSKIYSLRETPRK"
     CDS             5508..5939
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.9; E-value:
                     3e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_6"
                     /sec_met_domain="Biotin_lipoyl (E-value: 6.2e-21, bitscore:
                     63.9, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNVYKVHINSVVDDIAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTTASGEPVVTRPAASTTQGAVKTPLPGVILQIKCNVGDTVKRGQTLLI
                     LEAMKMENNINADRDGKIIEIKVHKGDSVLEGADLVVIG"
     CDS             5944..7104
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg26_7"
                     /sec_met_domain="OAD_beta (E-value: 4.6e-154, bitscore:
                     502.3, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLSFLGDNLQLFLTYTGVYNATPGHIIMILVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQVGIYEQGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYIIALQMGFEPNQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERLIRMKPPRAVSSTEKIIFP
                     IVGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLAETARGPLIDTITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKFFNLFLKQGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             7608..9347
                     /locus_tag="ctg26_8"
                     /transl_table=11
                     /translation="MSQVKGIPYGISDFKRLRNENFYYVDKTMYLPLIEKMPSYLFLIR
                     PRRFGKSLFLSLMRTYYDILQKDNFEKYFGDLWIGSHPTDQRNRFQVLYFDFSKAGCSQ
                     PGTDMMTSFNDYCGLIINQFAHEYASYYDADYKATIENIASAKAKLSYIEIKAKEKGYP
                     LYLIVDEYDNFTNVILSEHGQKMFHDLTHASGFYREYFKQFKGMFDRIFLMGVSPITLD
                     DLSSGYNIDWNISTDETFNAMMGFDETDVREMFHYYRQNDMLTGDIDTMIAEMKPWYNN
                     YCFARMALDSDRVFNCDMILYYLHNQVNFHRAPEEMVDKNICINYSKLKKLTGINHKSL
                     HEDSCMNTIKDIVAKGEVLVDLHTSFPAEKVMDIDNFRSLLYYYGLLTMCGTHGKLLKM
                     CIPNNCVREQYFGFLRDYYQQFHTINLSHLKDLIDDFAYDGQWKPFFESIALAYRENSS
                     VRDAMEGERNLQGFLKAYLALASYYLVEPELEMNYGYCDFFLLPDKKRYPDIGHSYILE
                     LKYAGRTTTDTELETQAEEGRQLLQYSKDKIALQLAQDTTLHLILLQFRGWDLVKCEEI
                     ASC"
     CDS             complement(9458..10171)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_9"
                     /sec_met_domain="Peptidase_M22 (E-value: 3.1e-26, bitscore:
                     82.4, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LRPINPVDEQRSSIEKYLSLVNRQLSTIMSCILNIETSTSVCSVA
                     LSADGEVLFEKSSFEGPSHAALLGVYVEEAIAVTKEKGLKLDAVAVSSGPGSYTGLRIG
                     VSVAKGLCFGYGIPLISIPTLEVLAVAALEQQNNASDCLYCAMLDARRMEVYAAIYDVN
                     LKTVRETSADIVDAETYASWLEKGKVCFFGNGAAKCREVITSPNALFIDNIHPLAVNMI
                     TLSEKAFAGXXXXXV"
     CDS             10311..11171
                     /locus_tag="ctg26_10"
                     /transl_table=11
                     /translation="MTGFGKVTAELPSKKVTVEIKALNSKQLDLSTRIPSIYKDKEMQI
                     RSQLLQSLERGKVDFSIYIEYIGKDTPTQINLTAFESYYSQVKDIAEKLNIALPADWFQ
                     TLLKMPDVIKSEIVEVDESEWEVVFNAVKGAIKHLCDFRIQEGAMLQKLFEDKIGNIAR
                     LLTEVEEYEGERIEKIKARIMDNLEKVANQDYDKNRFEQEMIYYIEKLDVNEEKNRLDN
                     HLKYFISTMKDGHGQGKKLGFIAQEMGREINTLGSKSNHAEMQKIVVQMKDELEQIKEQ
                     VLNVL"
     CDS             11173..11742
                     /locus_tag="ctg26_11"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINHLLKQNLNLHFSISATSRAPRGTE
                     QNGVEYYFLTPDEFRARIAAGDFLEYEEVYTDKYYGTLKSEVERQLNEGNNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPSIAHLRERLEGRGTDAPEVIDSRIAKAEFELGFIPHFD
                     VCIVNDDLATAQAEAVEVIKDFLSKE"
     CDS             11739..11918
                     /locus_tag="ctg26_12"
                     /transl_table=11
                     /translation="MNNNRQLSRKWGYIFALTGIAALGTCIAGLIYKEYLIAFATGLVF
                     GVQAFNFIMWKKQR"
     CDS             11900..12289
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg26_13"
                     /sec_met_domain="CTP_transf_like (E-value: 5.5e-18,
                     bitscore: 55.4, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VEETTVKENNKLKTGIFSGSFNPVHIGHLALANWLCEFAGLDELW
                     FVITPHNPLKKRDDLMDDRLRLELVEAAVAGYAKFRTSDIEFTLPQPTYTIDTLRTLDR
                     TYPDREFHFIMGADNWSSINRWKESE"
ORIGIN
        1 gctatttata ttagtttcaa tcagcgcttt tggacaaaag catgttaaaa tcacgggata
       61 tgttcgggat gccgacggta gtccgcttga acttgtgctt gttcagataa agaatacgct
      121 gaacggggca atgaccaatg aaaagggtta ctattcgatc tccacgtcgc cgggcgattc
      181 cgtagcggtt attttctctt gtctgggata taataaggca gaacgtattc tacccagttt
      241 gcaacaggac atgcggctga atgtacagat gaactacaca agtatcgacc tgggagaagt
      301 tgttgctgta ggtacccgtt accaaaccag tacccttcaa accatgaatg cagaccgtgt
      361 caagctcctc cccgaccctg ccggcggaag catcgaaagt ctcgtggtca cttttgccgg
      421 agtttcatcc agcaacgaat taagttccca gtattcggtt cgcggcggta gttacgatga
      481 aaacatagta tatgtaaacg gcctggaagt attccgcccg ttactgatcc gttccggcca
      541 gcaggaaggt ctgagcttta tcaatcccga cctgaccgaa gcggtcaact tcgcagccgg
      601 aggatttgaa gcacggtatg gagataaaat gagctctgtt cttgacatca cctataaaaa
      661 acccaagtta tttgaaggat cggcctccgc cagcttactg ggagcaaacg cctatgtggg
      721 cagttccatc ggcaagttca cacaaataac cggtgttcgt tataagacag gacgttcgct
      781 actaaaaaca atggatacgg acgccgaata ccagccggat ttcgtcgatc tgcaatcata
      841 catgacttat cagttagctc cgaaatggga agtaaacttt ctggggaacc tggcgtccaa
      901 cacgttcaaa ttcaccccgc ataaacggga gacaaacttc ggtacggtag aaaacgccca
      961 acggtttgaa gtgtatttcc ccaacagccg cgagcgggat aagttccaga caatcttcgg
     1021 cgcactgacc ttgaaacaca atccgaacga gaaaacagaa ctgggcctcc aggcatccgc
     1081 tttctccagc aaggaaatag aaacctatga catcaccggc gaatactggc tgggcgatgc
     1141 tacaacagaa aacgacaata accagaatgc ccttgaaata gcccgctacc atgagcatgc
     1201 ccgcaaccgt ttaagttcaa ccatcatgaa tgtgggacat tacggcagta gcaagatcaa
     1261 aaacaacacg ctgaaatggg gagccaccgt acagatggaa aagataaacg accgcatcag
     1321 cgaatgggaa aaacgcgact cggcaggtta ctcacttcct caaacaggga acggggtaaa
     1381 cgtgatctcc aatctttatt cggacaatga tttgtcgact acccggatat cgggatattt
     1441 gcaggacgtt ttcaagttcc gtaccaagca aggtatgttc acactcatcg gcggtatccg
     1501 cggaagctac tggagctata acaaagaatt cattttcagc ccacgcgttt ctttaggttt
     1561 tatccctaat ttcgatcaga atctgacctt tcgtgcagcg acaggtatct actaccagtc
     1621 accgttctat aaagaattac gaaccaccgt gcaggatgcc gcaggcaatg atattatcga
     1681 actgaacaag gatatcaaat cgcaacgttc catccatttc attctcggtg gcgattatac
     1741 gttccgggca gccgaccgta actttaaagt cagtgccgac ctctattaca agaaactgga
     1801 cgacctgatt ccttacaccg tcgacaacgt aaagatccgg tactacggag agaactgtgc
     1861 caaaggccat gcaatgggta tcgatgttaa attcttcggt gaatttgtac ccggaaccga
     1921 ttcatggatc agcttctcgc ttatgaaagc agagcaaaca atccgtgaca tggtaaccgt
     1981 tcccatgccc aacagccagg gatataacgt atcgttattc tttcaggatt attttcccgg
     2041 atacaaacgt gtaaaactga atctgaaagg cgtcctctcc ggcggacttc cttttattgc
     2101 accacgcacg aaatacgtac tttccgcacg ccggcctaca aacgtgtcga cctcggtttc
     2161 tcttaccagc tggccggagg aaccgatgcg atcatggacc gcggagtctt tcgtcacctg
     2221 aaaaatatct ggatcggagt ggacgtattt aacctgttcg atataaaaaa tgtcagttcc
     2281 tattactgga tcaccaacat cgacaaccag caatatgctg taccgaatta cctgacaggc
     2341 cgacaactca atgcacgact gattgtcgat ttctaaaaat atgccaataa gataatttgc
     2401 caatatgccg ataaaaaaca ggatttgcca atgagaagtc aaggctttca ttggcaattt
     2461 tgcatattgg caaattggca aattattatt aatgaaatat ttcttgattc ttcaaaaaga
     2521 atgtaccttt gccatcaaaa caaaaagcat ttatcaatta ttaaattctt attgacatgg
     2581 aaattacaca tattgaacat ctgggaattg cagtaaaaag catcgaagct tgtctgccgt
     2641 attatgaaga aattttaggc atgaaatgct acaacatcga agaagttgct gaccaaaaag
     2701 taaagactgc gttctttaaa gtaggccaaa caaaaatcga attacttgaa ccgaccagcg
     2761 aagacagcac tatcgccaaa ttcatcgaaa agaaaggcga aggtattcac catatcgcat
     2821 ttgctgtacc tgatgtacag gctgcattgg acgaagctga atcaaaaggt gtcaaactga
     2881 tcgacaaagc tccccgcggt ggtgcagaag gtctgaacat tgcattcctt cacccgaaat
     2941 caacttgcag cgtattgact gaactttgca tgccgggtaa aaaataatta atcagttcat
     3001 ttctaacaac aaatcagaaa tacaatgagt aaccaacttg aaaaagtaaa agagcttatc
     3061 gctcttcgcg aacaagcccg tttaggtggt ggagaaaaaa gaatcgaatc tcagcacaag
     3121 aaaggcaagt acacagcacg cgaacgtatc gccatgttgc ttgacgaagg tagtttcgag
     3181 gagtttgata tgttcgttca gcaccgttgt actaacttcg gtattgaaaa aacaaaattc
     3241 ctgggtgatg gtatcgtaac cggatatggt acgatcgacg gccgtttggt ctacatcttc
     3301 gcacaggact tcaccgtatt cggaggagct ttgtcagaat cactggccat gaagatttgt
     3361 aaggtaatgg atcaggccat gaagatgggt gcccctgtca tcggcttgaa cgactcaggt
     3421 ggagcacgta tccaggaagg cgttaacgct ctggcaggat atgctgaaat cttccagcgt
     3481 aatatccttg catccggtgt tgtacctcag atttcaggta tcttcggtcc gtgtgcaggt
     3541 ggcgcagttt attctccggc gctgactgac tttaacatca tgacacgtgg taccagctac
     3601 atgttcctga caggtccgaa agtagtaaaa accgttaccg gtgaagacgt aactcaggaa
     3661 caactgggtg gcgcaagcgt acacacaacc aaatcgggtg ttgcccattt cgctgtcgac
     3721 acagaagaag aaggtctgca actgatccgc aaattgctca gcttccttcc gcagaacaac
     3781 ctggaagaaa ctccgctgat cgaatgcaaa gacccgatcg accgtctgga cgatgtattg
     3841 aacgacatca ttcctgacaa cgctaaccag tcatatgaca tgtatgaagt aatcggcaca
     3901 atcgttgaca acaacgaatt cctggaagta catgctgatt atgctaaaaa tatcatcatt
     3961 ggtttcgcac gtttcaacgg ccagtctgta ggtatcgtag ctaaccagcc gaaagtaatg
     4021 gcaggctgtc tggacagcaa cgcttcccgt aaggcaggcc gcttcgttcg cttctgcgac
     4081 gctttcaaca ttcctttggt aacattggta gacgtaccgg gattccttcc gggaacaggc
     4141 caggaataca atggtgtaat ccttcacgga gccaaattgc tttacgctta cggcgaagca
     4201 actgtgccta aaatcactgt tacattgcgt aaatcttacg gtggtgctta ctgcgtgatg
     4261 agttctaaac acctgcgtgg cgatatgaac tacgcatggc cgacagcaga aatcgcagtt
     4321 atgggcccga gcggtgctgt agaagttatc ttcgcaaaag aagttgccgc atccgaagat
     4381 cctgcaaaag caacagccga aaaagaagca gaatacaaga aagcattcgc aaacccgtac
     4441 aacgcagctc aatacggtta tatcgacgat gtgatcgaac cgcgtaatac ccgtttccgt
     4501 atcattcgtg ctttacaaca attgcagacg aaaaagttaa gcaatcctgc taagaaacat
     4561 gacaatctgc ctctataatt cttaaaacag gaaaatgaat atgactaaca aaagatttgg
     4621 agtattgctg ctgttcatcc tgctcgtatc attcggggca caggcacagc gtgcaacctc
     4681 catgcgaata aatgaagtgc tggtcatcaa cgaagataat ttcgttgacg actatggcaa
     4741 acgtcacggc tggatagaat tattcaatac ttctgccgga acggttaata ttgcaggttg
     4801 tttcttgaca gacgacaaga acaatcctaa aaaatatccg atccccaagg gtgacgtact
     4861 aactcagatc cccccccatc aacacactct gttctgggcg gatggtgaac ctaaccgtgg
     4921 tacttttcat gtcaatttca cgttagaccc gtcaaaagaa aattatatag cactttatga
     4981 cgccgatggt aaatccttga tcgacgaaat aacaattccg gctgcacaaa aaccggatgt
     5041 tagctatggt agaattattg acggaaaaga agaatgggca caactcacaa aagtgactcc
     5101 cagcacaaac aacctgacgt tagattctaa cgaaaagatc gaaaacttta agacaaatga
     5161 ctctttgggt atcggtatga ctattacagc tatggctgtt gtttttctag gcttgctcct
     5221 tcttttcctg atcttcaaac aagtcggaaa agcagctatc gcagccagca aacgtaatgc
     5281 tcagaaagca ggggcacctg ttaatgtaaa tacaccggac gaagtttcgg gcgaagtttt
     5341 tgcagcaatc gctacagctt tgtatgaaat gagtgatgac aatcacgaca tcgaacatac
     5401 agtgcttaca atccgcaaag ttcgccgtgc atattctcca tggagttcta agatctatag
     5461 tttacgtgaa actcccagaa agtgattatc tctaaaaaca aacaagaatg aaaagtttta
     5521 aatataccat caacggtaac gtatataaag tacacatcaa ttcagtggtc gacgatatcg
     5581 ctgaagtaga agtaaacggt actccttata atgtaaaaat ggagaaaccg gcgaaaaaac
     5641 aaatggttac actcaaacgc ccggcacagg ctcctactac agccagcggc gaaccggttg
     5701 ttactcgtcc ggcagcatct acaacccagg gcgccgttaa aactccgctt ccaggtgtta
     5761 tcctgcaaat caaatgcaat gtaggcgaca ctgtgaagag aggacaaact ttacttatcc
     5821 tcgaggctat gaagatggaa aacaacatca acgctgaccg cgacggtaag attattgaaa
     5881 ttaaagtaca taagggagac tccgtactgg aaggtgctga tctcgtcgta atcggataag
     5941 agtatgcaag agagtttttt atcattcctg ggtgacaacc tacagttgtt cctcacctat
     6001 acaggagtat ataatgcaac tccgggccat atcattatga tattggttgg tttgctcttt
     6061 atattccttg cgattaaata tgaatttgaa cccatgttgc tgatccctat cggattcggt
     6121 atcctgatcg gtaacattcc ttttaaagat gcagggcttc aggtaggtat ctacgaacaa
     6181 gggtctgtac ttaacatcct ctatcaaggg gtaacctccg gatggtatcc gccgttgatc
     6241 ttcctcggta tcggggcgat gaccgacttc tccgctttga tttccaatcc aaagctgatg
     6301 ttgatcggtg ctgccgccca gttcggtatc ttcggtgctt atattatcgc tcttcagatg
     6361 ggattcgaac cgaaccaggc cggtgctatc ggtattatcg gtggtgctga cggtcctacg
     6421 gctatcttcc tgtcttccaa gctggcccct aacctgatgg gtgctattgc ggtgtcagcc
     6481 tactcatata tggcgttggt acctattatc cagccgccgt tcatgagact gcttacaaca
     6541 aagaaagaac gtctgatccg tatgaaaccg ccgagagccg tttcttctac agaaaagatc
     6601 atcttcccga tcgtcggtct gttgctgact tgcttccttg taccttcagg tctgcccttg
     6661 ctgggtatgt tgttcttcgg aaacctgttg aaagaaagtg gtgtaacccg tcgtctggct
     6721 gaaacagccc gcggtccgct gatcgataca atcaccatcc tgttaggtat cacagtaggt
     6781 gcttctacac aggcaactca gttcctgaca ctgaactcta tcaagatctt cggtttaggt
     6841 gcgttgtcat tcgtgattgc aacctgtgcc ggtgtattgt tcgttaagtt cttcaacctg
     6901 ttcctgaaac aaggcaacaa aatcaatccg cttatcggta atgccggtgt atctgctgtt
     6961 cctgactcag cacgtatctc tcaggttgta ggtctggaat atgacccgac caactatctg
     7021 ttgatgcacg ccatgggtcc gaacgtagca ggtgtaatcg gttctgctgt agcagccggt
     7081 atcctgttag gattcttagg ataataaaac aagtgacagt tgatagatgg caagtgacag
     7141 ataaatagaa tcttttctaa atctgtcaac tgtcacttat caactgtcaa ctttttatac
     7201 attttgttcg acctccatcg gatttgtttc cggattagtt acttcttcca atgtcgtccc
     7261 cacaaacaac cataccatca aaaggacaat cgcaataata accccgatga tcaaccatag
     7321 atttttcttt ttcatacctt cgtaattctg attttgtttt atatgagcat aaaacaacag
     7381 aaacaagtct ttggtttaaa aagatctatg agtaaaatac gaaacctact gccatactat
     7441 catagttgac aaatattcat ccgattacaa atgatttagc accatactct catacgcaat
     7501 tcatataata atagactgta aaacacaaag ctggaatact ttctcaaaca ttgttttatt
     7561 tgccggaata aactaacttt gtctctatat cttaaaaagt atccaacatg agccaagtaa
     7621 aaggaatacc atacggaata tctgatttca aacggttgag aaacgaaaac ttttattacg
     7681 tagacaagac gatgtatctg ccgctgatcg aaaagatgcc cagctacttg tttcttatcc
     7741 gtcccagacg attcggaaaa agtctgttcc ttagcttgat gcgtacctat tatgatatat
     7801 tgcaaaagga taatttcgaa aagtatttcg gcgatttatg gattggcagc cacccgaccg
     7861 accagcgcaa ccgctttcag gtgctttact tcgatttctc aaaagccggt tgttcgcaac
     7921 cgggaaccga tatgatgacc agcttcaacg actattgcgg tctgatcatc aatcagttcg
     7981 cacatgaata tgcatcctat tacgatgccg attataaagc tacgatcgaa aatatagcaa
     8041 gtgccaaagc aaaactgtcg tacatcgaga taaaagcaaa agaaaaaggg tatccgcttt
     8101 atcttatcgt agacgaatat gacaacttca caaacgtcat actgagtgaa cacggacaga
     8161 aaatgtttca cgacctaaca catgccagcg gtttctacag ggaatacttt aaacagttca
     8221 aagggatgtt cgaccggatt ttcctgatgg gggtcagtcc tatcactttg gatgatttat
     8281 cgagcggtta taacatcgac tggaatatct cgactgacga aacttttaac gcaatgatgg
     8341 gattcgatga aacagatgtt cgtgaaatgt ttcattatta ccggcaaaac gatatgctga
     8401 caggagacat agatacaatg atcgcagaaa tgaaaccgtg gtataataat tattgtttcg
     8461 cacgaatggc attggatagt gaccgggtgt tcaattgtga catgattttg tattatttac
     8521 acaatcaggt aaatttccac cgtgccccgg aagagatggt agacaaaaat atttgcataa
     8581 attacagcaa actaaaaaag ctaaccggta tcaaccataa aagtttacac gaagatagct
     8641 gtatgaatac tatcaaagat attgtcgcaa aaggagaagt gctagtcgac ttgcacacct
     8701 ctttcccggc tgaaaaagta atggatatcg ataatttccg aagtctactt tattactacg
     8761 gactgcttac tatgtgcggt acacacggaa aactattaaa aatgtgtatc cccaataatt
     8821 gcgtacgtga acaatacttt ggtttcctgc gcgattatta tcaacagttt catacaataa
     8881 acctttctca tctgaaagat ttaatagacg acttcgctta cgacggccaa tggaaaccgt
     8941 ttttcgaatc catcgccctt gcctatcgtg aaaactcttc cgtacgtgat gctatggaag
     9001 gagaaagaaa tctgcaaggt tttctgaagg catatctggc actcgcttct tattatctgg
     9061 tagaaccgga actggaaatg aattacggtt actgcgattt ctttttatta cctgacaaaa
     9121 agcggtatcc cgatatcgga cacagctaca tattggagtt aaagtacgct ggacgtacca
     9181 ccaccgacac ggaactcgaa acgcaagcag aagaaggacg ccaactatta caatacagta
     9241 aagacaaaat cgctttacag ttggcccaag acacaacact tcatttgata ctgcttcaat
     9301 tccggggttg ggatttggtt aagtgtgaag aaatagcttc ctgctaacaa tcttcaccgg
     9361 atgatagctt tcaaaacgct atcatcccaa caccttattc ttagcgattg ttgcctgaaa
     9421 ttctttcagg tagaacggct cgaaataagc gacatcctca aacnnnnnnn nnnnnnnttc
     9481 cggcaaatgc tttttcagac aaggttatca tattaacagc cagcgggtgg atattatcaa
     9541 taaagagcgc attcggagaa gtaatcacct cccgacattt ggctgcaccg ttcccaaaga
     9601 aacaaacttt ccctttttcc agccaggaag cataagtttc tgcatctaca atatcagcag
     9661 acgtttcgcg aaccgtcttc aaattaacat catagatagc tgcatacacc tccatccgac
     9721 gggcatcgag catggcgcaa tacaaacagt cggacgcatt attttgctgt tccaatgcgg
     9781 caacagccaa cacttccagc gtagggatac tgatcagagg tatgccgtaa ccgaaacaca
     9841 aacctttggc gaccgatacg ccgatacgca atccggtata agatcccgga ccgctgctga
     9901 cagctactgc atccagcttc aatccttttt ctttggtcac cgcaatagcc tcttccacat
     9961 aaacacccaa caaagcagca tgcgacggac cttcaaacga actcttttca aaaagcacct
    10021 caccatcagc cgataaagcg acggaacaca ccgaggtcga tgtttcaata tttaaaatac
    10081 aagacataat agttgacagt tgacggttga caagtgacag atatttttca atagaactcc
    10141 gctgttcatc aaccggatta attggtcgca aaagtacaaa aacgtcttta tacgaatgag
    10201 aaaataacga actttttctc tatcaggacg aagaattatc aactgtcaac tgtcaactat
    10261 caactgaata agctatcttt gcacaaattt ttagaacaat gatacaatca atgactggat
    10321 tcggtaaggt tacagccgaa cttccttcaa aaaaggtaac cgtagaaata aaagcactca
    10381 acagcaaaca actggattta tcaacccgca tcccttctat ctacaaagat aaggaaatgc
    10441 aaatccgtag ccagctgctt cagtcgcttg aacggggtaa ggtcgatttc agcatttata
    10501 tcgaatatat aggaaaagat actcctaccc agatcaacct taccgctttt gaaagttatt
    10561 acagccaggt taaggatatt gcagaaaaac tgaatattgc acttccggct gactggttcc
    10621 agacattact aaaaatgccg gacgttatca aatctgaaat tgtagaagta gacgaaagcg
    10681 aatgggaagt tgttttcaat gcggtaaagg gagccatcaa acatctttgt gacttccgca
    10741 tccaggaagg cgccatgctg caaaagttat ttgaagacaa aatcggtaat atcgcccgcc
    10801 tgctgaccga agtggaagaa tatgaaggcg aacgcatcga aaagatcaaa gcccgtatca
    10861 tggataacct cgaaaaggta gccaaccagg attacgacaa gaaccgcttc gagcaggaaa
    10921 tgatctatta catcgaaaaa ctggatgtga acgaagaaaa gaaccgcctc gacaaccatc
    10981 tgaaatattt catcagcacg atgaaagacg gacacggaca aggcaaaaag ctcggtttca
    11041 tcgctcagga aatgggccgc gaaatcaaca cgctcggttc gaaaagcaac catgcggaaa
    11101 tgcagaaaat tgtcgttcag atgaaagacg aactggaaca aatcaaggaa caggtactaa
    11161 acgtattata atatggctgg taaattaatt atattctccg ccccgtcagg ctcaggtaaa
    11221 tcaaccatca tcaaccatct gctaaaacag aacctgaacc tgcatttctc tatctcggca
    11281 acaagccgtg caccgcgcgg aacagaacag aacggtgtgg aatattattt cctgactccc
    11341 gacgaattcc gggcccgtat cgctgccggt gattttctgg aatatgagga agtatatacc
    11401 gataaatact acggcacatt gaaaagtgaa gtggaacgcc aactgaacga aggcaacaac
    11461 gttatattcg atgtggacgt tgtcggcgga tgcaacatca aaaagtttta tggtgaccgt
    11521 gctctttcag tatttatcca gccgcccagc atcgcccatc tgcgtgaacg tctggaaggt
    11581 cgtggtacgg atgctcccga agtgatcgac agccgtatcg caaaagcgga attcgaactg
    11641 ggatttattc ctcatttcga tgtctgcatc gtaaacgacg accttgcgac agcacaggcc
    11701 gaagcagtgg aagttataaa agattttctg tctaaagaat gaataacaac agacaattat
    11761 cacgtaaatg gggatatatt ttcgcactga ccggaatcgc ggcattggga acctgcattg
    11821 caggcctcat ttataaagaa tatctcattg catttgcaac cggactcgta ttcggcgtac
    11881 aggcattcaa ctttataatg tggaagaaac aacggtaaag gaaaacaaca aactgaaaac
    11941 cggaatcttt tccggttctt tcaacccggt tcacatcggt catttggccc tggccaactg
    12001 gctgtgtgag tttgcggggt tggacgaact gtggtttgtt atcacgcctc ataacccgct
    12061 aaagaaacgc gacgacctga tggatgaccg gctccggctc gaactggtcg aagctgccgt
    12121 tgccggatat gctaaattcc gtaccagcga tatcgagttt acgcttcccc aaccgactta
    12181 cacgatagac accttacgta ccctcgaccg tacatatccc gaccgcgaat ttcattttat
    12241 aatgggagcc gacaactggt cgtcaatcaa tcgctggaaa gaatcggaa
//
