LOCUS       c00011_gnlPro..        15683 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|NGEKMNGG_11.
ACCESSION   c00011_gnlPro..
VERSION     c00011_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 08:23:45
            Original ID  :: gnl|Prokka|NGEKMNGG_11
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15683
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15683
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2283:5683]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2284..5683
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..15683
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..15683
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             3..68
                     /locus_tag="ctg11_1"
                     /transl_table=11
                     /translation="TAKFYEKAHSICIKNRLSVIR"
     CDS             complement(117..1652)
                     /locus_tag="ctg11_2"
                     /transl_table=11
                     /translation="MEAALEPDPLPFEAIRIHDERTVGPPSTSADGHSAHGTFTIPEGA
                     EGKKLYGTCSLFLGVDDWGSLEVKDSGGNVVAQVDLKENPQTAGEQGGHKYHTGTGGAQ
                     LPSGAYSWEVSQTNIDYNPASGNTSICNYSIDVVPTEPGGRKEPEPCPCEGDTCDNSGG
                     TPPSPPPSPPPSPPPSPPPSPPLARSGPEAGMESGALGNYSSAGCSVTAESTATLMYWS
                     CNFGAFRGLGGLLAGRVELRAEQNVSGLESPSSLAYNHPLNSRLDVPEGGIAPGVRFNL
                     VQGDRVIAMRCYTDGSVLPIGVDTSGGGRAALATVEGQSCLRWVVEDGSQYLFSAETGT
                     LLSYTTTDRQVISNASSYLDVRHAGDGSLRQIWNLWDGLLNVENVTSTGYTIALYTPGQ
                     ITGTDEQGFYTVTGAPLKTFILSLDAEEKFTITEQAPARQPYAVTWWNDGLAWNMRQGT
                     GEDALTTLRTRTELEPENSVWQLVTEISKNGIPFCLRFGLFDFILHNLRKNFK"
     CDS             1719..1889
                     /locus_tag="ctg11_3"
                     /transl_table=11
                     /translation="MRRIHQVLRVSIDNEIRREQPSIIIFVVALFRFSVNKNLFENFCY
                     FKNMRIYSMRK"
     CDS             complement(2284..3114)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.6; E-value: 9.2)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_4"
                     /sec_met_domain="Fer2_3 (E-value: 2.8e-23, bitscore: 74.1,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 9e-11, bitscore: 34.2,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.9e-06, bitscore: 19.0,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LPSAATSKDSQYINTQKKDYNMAKTLNLTLKVWRQENREAKGRIE
                     TYAAKDIPVDASFLEMLDIVNEGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPER
                     QVTTCQLHMRKFKDGDTVWIEPFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAP
                     NANNIAVEKVKADAAFDAAACIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSK
                     RVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(3092..5050)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 175.2; E-value:
                     8e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_5"
                     /sec_met_domain="FAD_binding_2 (E-value: 8.4e-54, bitscore:
                     175.2, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWLPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(5072..5683)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_6"
                     /sec_met_domain="SucD_FumR (E-value: 3.1e-13, bitscore:
                     41.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LFLAGHLAGNLLIFGGPEWINTYAHGLHSMPEAALWGIRAGLAVI
                     FIIHVWLTIQLKLENHAAREPYVFKNTIKATLSSRYMIYTGLTVLVFLIYHLYQYTLRV
                     GYDPAQFTTFISDGTVETFDVYKMIVTGFSNVWCSAFYILAVLMLFSHLRHGVQSIFQT
                     VGVDSRKIRPFYNFIAIAYGAIICLGFISVPASVLLGIIK"
     CDS             5974..6246
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             6249..7064
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLVLTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(7098..7505)
                     /locus_tag="ctg11_9"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSPKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(7760..8467)
                     /locus_tag="ctg11_10"
                     /transl_table=11
                     /translation="MKKLLSTLILSAGMSLSATANTTLLDSSIVGYSDFTSQTADFGTL
                     KDSVSITPDVSNLTLSGITFNGYGTNNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             complement(8498..8587)
                     /locus_tag="ctg11_11"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKRKCIH"
     CDS             8792..9502
                     /locus_tag="ctg11_12"
                     /transl_table=11
                     /translation="MGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGLGSSSLAPSDS
                     SSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNTGTTAAGINLT
                     FSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAPTANTEGDTVT
                     ISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEMVPEPATVSLG
                     LLGLAALMMRRRRA"
     CDS             complement(9720..9854)
                     /locus_tag="ctg11_13"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGRYVKAAVYHMDEKRAAEFDGIFR"
     CDS             complement(9966..10166)
                     /locus_tag="ctg11_14"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             complement(10180..11385)
                     /locus_tag="ctg11_15"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPVA
                     GASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             complement(11409..12155)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_16"
                     /sec_met_domain="adh_short_C2 (E-value: 2.4e-75, bitscore:
                     245.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSCGG
                     AAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLRMK
                     EEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKAGL
                     IGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDIAA
                     LTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(12285..12803)
                     /locus_tag="ctg11_17"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             complement(12867..14342)
                     /locus_tag="ctg11_18"
                     /transl_table=11
                     /translation="MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITP
                     EMEQAIHTIRTAENANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRP
                     AREMSGGWIMRAYLAKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHD
                     RDFMDELVESVYDIDNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFID
                     RFRSINSKAGQVQSRIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSY
                     GDRRVYENLDLLVERGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFS
                     QARTENLNPENTVLEEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLS
                     LVKFLVDPPNLLLMDEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLH
                     VNRGTITAYAGGYDYYLEKSGILDDEKGGITAE"
     CDS             14407..14553
                     /locus_tag="ctg11_19"
                     /transl_table=11
                     /translation="MVISVSLNKVRPAWDFVRFLIVSMVKRGCILPGWKGEGKSRQGGG
                     RHF"
     CDS             14717..15307
                     /locus_tag="ctg11_20"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVAQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAAGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
ORIGIN
        1 taacggcaaa gttttacgaa aaagctcata gtatatgtat aaaaaacagg ctctcggtaa
       61 tccgatgagc ctgtttttta caattcacgt actcaacata tacaattggc gaacaactac
      121 ttgaaatttt ttcttaaatt atgtaaaata aagtcgaata agccaaacct taaacagaaa
      181 gggattccgt ttttggagat ttccgtgacc agctgccaga ccgagttttc cggttccagc
      241 tccgtgcgcg tgcggagggt cgtgagggcg tcttcccccg tgccctgccg catgttccac
      301 gccaggccgt cgttccacca ggtgacggcg tagggctgcc tggcaggcgc ctgttccgtg
      361 atggtgaact tttcctcagc atccagggaa agaataaatg ttttcaaggg agcgcccgta
      421 acggtataaa atccctgttc gtccgttccg gtgatttgcc caggggtata gagcgcgatg
      481 gtgtagcccg tggaggtgac gttttccacg ttgagcaggc cgtcccacag gttccagatt
      541 tgcctcagcg agccgtctcc ggcatgcctg acgtccagat aggatgacgc gttggagatg
      601 acctgcctgt ccgtggtggt gtaggagagg agcgttcccg tttccgccga gaagaggtat
      661 tggctgccgt cttccaccac ccagcgcagg caggattgtc cttccaccgt ggccagcgcc
      721 gcacgccctc cgcccgacgt gtccaccccg atgggcagca cggacccgtc cgtgtagcag
      781 cgcatggcaa tcacccggtc tccctgcacc aggttgaacc gcactcccgg cgcaatgccc
      841 ccttccggca cgtccagacg gctgttcagg ggatggttgt aggccagcga ggaggggctt
      901 tccaggccgg agacgttttg ttcagccctc agttccaccc ttccggccag aaggccccca
      961 agtccacgga acgctccgaa gttgcaggac cagtacatca gcgtggccgt gctttccgcc
     1021 gtcacgctgc accccgccga gctgtagttt cccagggcgc cgctttccat gcccgcctca
     1081 gggcccgacc gggccagcgg cggggaaggc ggcggggaag gcggcgggga aggcggcggg
     1141 gaaggcggcg gggaaggcgg cgttccgccg ctgttgtcgc acgtgtctcc ctcgcagggg
     1201 cacggttcgg gttctttcct gccccccggt tccgtcggca ccacgtcgat gctgtagttg
     1261 cagatggagg tgttgccgct tgccggattg tagtcgatgt tggtctggct gacttcccag
     1321 ctgtaggcgc cggaggggag ctgcgccccg ccagtccccg tgtggtattt gtgcccgccc
     1381 tgttcgcccg ccgtctgcgg gttttctttc agatccacct gcgccaccac gttgccgccg
     1441 gagtccttta cttccaggct tccccagtcg tccaccccaa ggaagagcga gcaggtgccg
     1501 tagagttttt tgccctccgc tccttccggg atggtgaatg tcccgtgcgc gctgtgcccg
     1561 tccgccgacg tgctcggcgg ccccacggtt ctttcgtcat ggatccggat cgcttcaaac
     1621 ggtagcggat cgggctccag agctgcctcc atgccccgcc tgccggggct gccgccggct
     1681 ccaaagtacc atttccggta agcgggaacg gcagaacgat gaggcggatt catcaggtat
     1741 taagagttag tattgataat gaaattagaa gagaacaacc ctctattatt attttcgtag
     1801 tagcattatt cagatttagc gtcaataaga atttatttga aaatttctgt tattttaaga
     1861 acatgagaat ttattccatg agaaaataat attataattc ttacgctcag tgcattccct
     1921 taatagacat caatgttgtc tgtttgttag aaaatgtttt cctctcatgc tgagcccttg
     1981 acaggaggcc atcccttccg ggcatcagtc taattcctgt aatcaatgtt tttctttctc
     2041 tcgaagaaag atggggccgt cgctgtcgga cgggggcttg cttaggtttc gtccggcatt
     2101 gccaagtacg gtctcctgga ttactgggtg ccttccggtg taacaatttt ttacgctgcg
     2161 cgacgatgag gaagcaactg tctggtattt tattcctggt tcaaggaaat ctggtaatga
     2221 aaaaactccc gacagccgat gccgccggga gtttttacag agcgtcttaa gaaggaatct
     2281 tctttagaaa cagaggcctt ccttggcgtt ggcccgcatg aagtcgcggt tgaggcgggc
     2341 gatgttgtcc acgctgatgc ctttcgggca ggcggcttca cattcatact ggttcgtgca
     2401 gttgccaaag ccttccgctt ccatctgctt catcatggcc aggacgcgct tggaacgttc
     2461 cggctggccc tgcggcagca gattgagatg ggcgatcttg gcggaggtga acagcatggc
     2521 ggaagcgttt ttacaggagg ccacgcaggc gccgcagccg atgcaggcgg ccgcgtcaaa
     2581 ggcggcgtcc gccttcactt tttccacggc gatgttgttg gcgttcggcg cggaaccggt
     2641 acgcacgtca atatagcctc cagcggcgat gatgcggtcc agggcggagc ggtccaccat
     2701 caggtcccgc aggattggga aagccttcgc gcggaagggt tcaatccaga cggtatcgcc
     2761 atccttgaac ttgcgcatgt gaagctggca agtggtcacc tggcgttccg gcccgtgggg
     2821 aatgccgttg atggtcaggg agcacatgcc gcagatgcct tcccggcagt cgtggtcaaa
     2881 atggatgggt tccttgcctt ccttgaccag gccttcattg acgatgtcca gcatttccag
     2941 gaaggaggcg tccaccggaa tgtccttggc ggcataggtc tcaatgcggc ccttggcttc
     3001 ccggttttcc tggcgccaga ccttgagagt gagattgagt gttttagcca tgttataatc
     3061 tttcttttga gtgttaatgt attggctatc tttacttgta gctgcggatg gcaaggtgca
     3121 cgttctcgaa ggtcagcggt tccttgtgga gaacaggcag gctgtccacg ccagtgtatt
     3181 cccaggcggc tacataggcg tattcatcgt cgttgcgctt agcttcgccg tccggcagct
     3241 ggtattccac gcggaagtgg gcgccgcagg attcctggcg gttcagggcg tcatagcaga
     3301 gcagctgggc gaattccagg aagtcggcca cgcggcaggc tttttccagt tccgcgttga
     3361 tgccgtccgc cgtgccggtt acgcgcacgt tttcccagaa ttccttgcgg agctggggaa
     3421 tgcgttcaat ggcgtgggtc aggctttctt ccgtgcgggc catgccgcag tcttcccaca
     3481 tgatgaggcc cagttcccgg tggaaggagt ccaccgtctt ggtgcccttc acattcagga
     3541 gcttgttgat gcgttccttc acttcgtctt ccgcagcctt gaattccggg gcggcggtgg
     3601 tgacggcgcc gggcttggtg gtcgtcaggt aagcgggcag cgtggcggga atgacgaagt
     3661 agccgtcaga caggccctgc atcagggcgg aggctcccag gcggttggcg ccgtggtcgg
     3721 agaagttggc ttcaccgagg acgtgcagcc ccttcacgtt ggacatgagg ttgtagtcca
     3781 cccacaggcc gcccatggtg tagtgggagg cggggtagat catcatgggc gtttcatggg
     3841 ggtcgtcgtc cgtgatttct tcgtacatgt caaacagatt gccgtattgg ccgtcaatcc
     3901 attcgcggcc catgcgcttg atttcatccg caaaatccag gaaaacgccc ttgccggtga
     3961 cggccacgcc gcggccgtcg tcgcaggctt ccttggcggc gcgggaggaa atgtcgcgcg
     4021 gagccaggtt gccgaaggag ggatacttgc gttccaggta gtagtcccgt tcttcttcgg
     4081 gaacatcgga aggcttgatt tcctttttac ggattttttc tgcggtttca cgggacttgg
     4141 gcaaccagat gcggccactg ttgcggaggg attccgacat cagcgtcagt ttggactggt
     4201 agtcgccctt gaccggaatg caggtggggt ggatttgcgt gaagcagggg ttggcgaaga
     4261 aggcaccgcg cttgtaggcc ttgtaggcgg cagtgacgtt gcagcccatc gcgttggtgg
     4321 acaggaagaa cacgttgccg tagccgcccg tgcagagcag gacggtatcc cctgcgtagg
     4381 atttgatttc gccggtaacc agattgcggg tgacgatgcc cttggcttcg ccgtccacca
     4441 gcaccagatc catcatttca tggcgggaga acatttcaat gtgtcccttg gccacttcct
     4501 tttccagggc ctggtaggca cccagcagga gctgctggcc cgtctgtccg cgtgcgtaga
     4561 aggttcgctt gagctgggcg ccgccgaagg agcggttgtc cagcaggccg ccgtattcac
     4621 ggccgaaggg aacgccctgg gccacacact ggtcaatgat gttggaggag acttccgcca
     4681 gacggtagac attggcttca cgggcgcgga agtcgccgcc tttaacggtg tcgtaaaaca
     4741 ggcggtaaac ggagtcgccg tcgttctggt agttcttggc tgcgttaatg ccgccctggg
     4801 ccgcaatgga gtgggcgcgg cgggggctgt cctggtagca gaagcatttg acgttgtagc
     4861 caagttcggc aagcgtggcg gcagcggagg cgccagccag gccggaacct accacaagca
     4921 ccgtgtactt gcgcttgttg ttcggattga tcagtttgga ctcaagtttg tacttggacc
     4981 atttgtcctg aatagggccg gagggaattt tggcatccgg catccagtcg cttacgggaa
     5041 aattaatcat gactttgaga ggagttgatg gttatttgat gatacccaga agaaccgagg
     5101 ccggcacgga gatgaagccc aggcagataa tcgcgccgta ggcgatggcg ataaagttgt
     5161 agaagggccg gattttgcgg gaatcgacgc ccacagtctg gaagatggac tgtaccccgt
     5221 ggcgcagatg gctgaacagc atcagaacgg ccaggatgta gaaggcggag caccatacgt
     5281 tggagaatcc ggtcacgatc atcttgtaca cgtcaaaggt ttccaccgta ccgtcggaaa
     5341 tgaaggtggt gaactgggcg gggtcgtatc ctacgcgcag ggtgtactgg tacaggtggt
     5401 agatcaggaa caccaggacg gtcagaccgg tatagatcat gtagcgggag gagagcgttg
     5461 ccttgatggt gttcttgaac acgtagggtt cgcgggccgc atggttttcc agcttcagct
     5521 ggatggtcag ccagacgtgg atgatgaaga tcaccgcaag ccccgcgcgg attccccaga
     5581 gggctgcttc cggcatggag tgcaggccgt gggcgtaggt gttgatccat tcagggcctc
     5641 cgaagatgag aaggttgcct gccaggtgtc ccgcaaggaa caagaccaaa cataaccccg
     5701 tcagagccac aatgattttg cggccgatgg aggatgtcac gaatgtacat atggttttta
     5761 ctagtgcatt cataggcgct ctaatgaaat aaatgcgtct tcacaggatg cccggttcaa
     5821 gcccggatgg caagcctctt cttgaatttc cggcgctttt cggatttttg aaaagccggg
     5881 gaaagaggtt gctgtttatc agtttggaat ggttatcatt ttgttgcctg ttccggcttg
     5941 acgaggcttt ccgcataggc gtatcgtctg tgcatgaaaa gaagtaaaaa ggaagtgctg
     6001 gacgcggatt tcgcagcggc gcgcgccggc gttctggatg tggccgcatt tctggaccgg
     6061 gtggaccgcg gggaagggga ggcggatttc cgttaccatg ccctgatgga tgttcttccc
     6121 ctcttatccg catccggccc cggacgcgtc cgggccattc tggaagccct ttcctacagg
     6181 gatgacaccg tgccggaaac cgccgcagcc aaagcggcct gcggagcccc gaacctcagc
     6241 aaataagaat gatggctttc atagaacctc atatacatat ggtgtgccgc accacggacg
     6301 aataccgggc catggcgcag gccggctgcc tggcggtagg ggaaccggcg ttctgggccg
     6361 gttacgaccg ttcgtccgcg gacggtttcc gggattattt cgtacagctt acggaatgcg
     6421 aacccgccag ggcggccaag ttcggcatgg accattacac atggctgtgc atcaatccca
     6481 aggaggcgca ggacgtggct ttcgcgcggg atgtgatgaa gctgattccg gagttcattg
     6541 accggcccaa tgtcctcggc atcggggaaa taggactgaa ccggaatact tcccatgaaa
     6601 tgactatttt tgaagagcat ctggatctgg cggtgcgcct caaccagctt gtgctgattc
     6661 acactcccca tctggaagac aagcttaagg ggaccgtaat gattctttcc gccctgaaaa
     6721 accgtccgga tctggaccct tgccgcgtgc tggtggatca ctgtgaggaa cataccttcc
     6781 cgctggtgaa ggaggccggt tactgggccg ggctgaccct ttatcccacc agcaagctga
     6841 atcccaagcg ggcggcggat attctggaat tgtacggaat ggaccgtgtc tgggccaatt
     6901 ccgcagcgga ctggggggat tccgatcccc tggtgctgac ggccctggcc tgcgagctgc
     6961 gcaggcgcgg tttttcccgg caggaaacgg aacgtcttct cctggaaaat ccggagacat
     7021 ttatgggaca gtccccgaag ttccggaaag tgtcgtcccg ttagttccgc ccgcggcgcg
     7081 gcgtagggta cggccctcta gtccccgtcc gggaaaaaga cggtgaggac ggcgcccagg
     7141 atgaccgccg cgtcatccag aaggcccagc ctgccgattc cgtcaaacag gaattcgtcg
     7201 ggagtcagga tgtaggcgcc ggcggcggcc agaaggcata tattccgttt gttgaaaaaa
     7261 cgcggttctc cttttctgct tttgaaatac cggaacaggc gcagtagcag ctgctgtttt
     7321 tgaaggttca tggacgggaa cgggggataa aggttcaagc tcagccattt tcccactcct
     7381 tttccctgtt tcggggaagg agtctgttgc cgacggacgg aaccgcagcg atccggaccg
     7441 tgcggggaaa tggattgctg aaaggatggg ctgttccgga tgctgaggga agccgggctt
     7501 tgcatgctcc ggttccggct gtcccggcat gggaaaaagg ggcgtgtacg gaagtggggc
     7561 ggggccggaa gctcttgaaa tgaccctacc gggggagact gaatgccatt tttccgtcaa
     7621 gtgctggccg tgaggttgcc gcagcaaatg gaagcttttc ccctctgttt tttcggcaga
     7681 tgtttgaacg gataaggaaa aggccggctc acgattttgt gagccggcct ttgaatatag
     7741 ggaggcggac ggtacaggct tatgccctgc ggcggcgcat catcagcgcg gccagtccca
     7801 gcaggcccag ggaagccgtg gcgggttccg gaatgctggc gatttcactc atcagttgac
     7861 caacttgttc ctgggaaagg agggagtcgt ggatgtagag ctgttcgatg gattcagcca
     7921 gtcctgcgtc catgagaatc tgatcaattt gctggttgcc gaatttcagg ccgctgttgg
     7981 aatagtacgt agcgctgtcg ccaaaataga tgcgggtgcc aagatctccg gtgactacgg
     8041 aaatggtcag ggacccttcc gtgcccagcg gggtgtcaac gacgggcccg ctgtatgagg
     8101 tgttgttcca taatccctgg agtttccggt ccgtgttcag gcccacgccc cagcttacac
     8161 tgctgttttt ggcgttaaac agagcggtat aggtctccgg agtgttgatt ttggacagat
     8221 caagaaccat cgtcacagac ataacgtcgc ggttgttggt accgtatccg ttgaaggtta
     8281 tcccggataa cgtcagattg ctgacgtcag gcgtgatgga aacggaatct ttcagggtgc
     8341 cgaaatccgc cgtttgggag gtaaagtccg aatatcccac gatagagcta tccagcagag
     8401 tggtattcgc ggtggcgctc aggctcatgc cggccgaaag aatcagggtg gataataatt
     8461 tcttcatggt cagtatctta ataaaatgat gcaagattca atgtatgcac ttgcgcttga
     8521 ataacgaatt tggaatccgc aagcaattaa aaatattaag agttagtata ttgtatttat
     8581 aattcattga aaataatgat tttttaatat ctctggtcct tttgtcaaga tgacggggca
     8641 atctttgtta ttcattggtt tcatgattga tttggcctct ttttcattac ttgacggatt
     8701 ccaaatccga ttggggaatt ccaaattcgc tacaagttgc catccaaaag gaataataaa
     8761 tatgaagaaa acactgacat ttttaatcgc gatgggaagc tttgctgttt cctcggaggc
     8821 agcgaccgtt tttaattatt acactcccgg tacggataat tacaatagta ccatccatgg
     8881 gttttatctt ggcctggggt cttcttccct ggctccttcc gattcctctt ctccctcctc
     8941 cctgtccgga gagatcagac tggacagttt tacgctgcgc ggagccgcca acaatttggg
     9001 cgctaatgtc acttacggct tcctggtgct gaatggctcc gacaattcgg tcatcggctg
     9061 gagcaccaat acgggaacta ctgcagcagg gattaatctg acgttcagtt tttcttccct
     9121 ggatggttct cccctgcttc ttgacgcggc attgacatac cgtttcctgg ccgtgagcca
     9181 gtccgtgatg gacttgatgc aggatacgtc taaaacgtat ttatatgctg cggggggaac
     9241 agccgcccct actgctaaca cggaaggaga taccgtaacg atcagcggcg gattgactgc
     9301 tcccggcatc cgcggccatt atgacgccga gggagcgcct ggtgattctg tcgttattac
     9361 gggagccaac ggaaccaata ctttcagctt attatccccg attttcacgg aaatccgagg
     9421 ggaaatggtg ccggaaccag ccacggtttc cctgggcctg ctgggactgg ccgcgctgat
     9481 gatgcgccgc cgcagggctt gagcttcctg atggcgaaaa atcggcggat gagagctgtt
     9541 cttgcggaac agctcttgtt ttttatatcc agagaggaag aattgcttat ccgtatgcgg
     9601 gattcatgcc ctccggaagg tacggaattt ccgggggcag ggggccgtat ccggtttttt
     9661 cggcatggcg gcaatttgct ggaaacgttt ttgagacgca gcaccggaaa gctttttctt
     9721 taccggaaaa tgccgtcaaa ttcggcagcg cgcttttcgt ccatatggta cacggcagct
     9781 ttcacatagc ggcctttcag gccggatagg gaaccccttt gcagctcaca gacctggagg
     9841 gccgccgcat acatattatt cgccgtccta ttccccggcg ctggtatttc ggaagaacgg
     9901 caatgggccc catgcccagc acttcatatt cttttccatc gtctgccctg atgacggacg
     9961 ttgcatcaac gatgtttccc gacgatgcgg ctgccgtgga cggcgactgc atccagctcc
    10021 gggatgaagg acggactgac gcgcatgata tggagcaggt aatgttcatg gcagccgggg
    10081 acgaaatagt tccagaacgc ttctctcgtg acatgttccg tttcggcatg gtctgaggat
    10141 tgttccgttc ttaatgcaat ggtcatgaaa ggttgttctt tacggctccc ccttggagaa
    10201 attccagagg cggtgcatcg tcataatgtc cggaatgttc atggggcgca ccacgcggaa
    10261 cccgatcatg cctccgtccg tcaggtacca gatgctttta gggttttgag gatcctgacg
    10321 gttccaggcg ggggtgctgg cgcggcgcgc agcgcttctc aggctgtccg ggtcgtcttc
    10381 ccacgaaccg ccgcgaacga tgtgaggggc gccggggatg atgaccaagg ggtctttcgc
    10441 gggcaagccg ctccgtttgc cgtaggcatc cggaacgtaa gagtccaaaa cccattccgc
    10501 cacatttccg tgcatgtccc ggagtcccca cttatttggt tttttagagc ctgttttctg
    10561 gtagcggtca ttggagttgt tccagtacca ggcgtactgg tccagagagg cttccccgtt
    10621 tccgtaagaa taggcgccgg gggagccggc ccggcaggcg tattcccatt ccgcctccgt
    10681 gggcaggcgg tagtaatgcc cggtctgggc gctcagccat tcgcagaatt tgctggcggc
    10741 gtggtgggac atggagatgg cgggcagacc gtgttcatag ccgtggccca tgcccaggtt
    10801 catggcggtg tagggggcgg taggctgcgt aacggagtcc cacagttcgt catccggctg
    10861 ttcctccaga agctggccgt ccttggcgcg cggacgcccg ttttccatga aggccgtata
    10921 aagttcccag gggatttccg tttccgagat ccagaagggg gagatgctca ctttatgctg
    10981 cggaccttcg tccggtttcc ggtgcggctc ttccgcggga ctccccatga ggaacgttcc
    11041 tcccggtatg gcgaccatgc gcagggaagc tcccgccacg ggaaccgttt ccgtgtagga
    11101 ttcaaaacgt gccggatttc cggaagcttc aatgagctga tggatttggc gcgttgtgcc
    11161 gaccagctcc cgggacggca ggtcatccgg aatgggaagg gcaggaccgg cagcgcggtc
    11221 cagttcccgt ttttgcagcg cggatcggct ttctccccac tggcgtgcgc tggtaatgcg
    11281 cgcggcatct tccgtggccg ggcgggggga attattttct tcccggcacc cggccagcag
    11341 ggcgcttcct cccagaaagc aggaaacaag gaaaatgccg cgcatggaat ggagaaaacc
    11401 ggaatgccct acatcgtcat gcctccgtcg caggcaatga cctgcccggt gatgtaacgg
    11461 gcatcgtcag aggcaaggaa ggccgtcagg gcggcgatat cttccacgga accttgttct
    11521 ttcaaaggta ttttcttaac gatttcttcc ttgagattgt cgggaatggc attggacatt
    11581 tccgtggaga tgaagccggg agcaatggcg ttgcacgtga ctttgcgcgg agcgaattcc
    11641 tgagccagtg atttggtgaa accgatgagg cccgccttgg aagcggcgta attagcctgg
    11701 ccgatgttgc cgacgagacc gatgacggag ctcatgttga tgatgcgccc ggccggggat
    11761 ttcatgagaa cgcgctggag ggccttgacc gtattgaacg cgcttttcag gttggtgtcc
    11821 agaacggcat cccagtcttc ctctttcatg cggagcatca gggagtcccg cgtgatgccg
    11881 gcgttgttca ccaggatgtc aatctgcggg aagtctttca aaatggcggc catggtttcc
    11941 tgaacggccg cgtaatccgc tacgtcgcag gggtaggcct tgcaggaatc cggaaattcc
    12001 ttgttgattt cttctgcggc ccccccgcag ctggatggac tgcggctgat caggatgacc
    12061 ctggctcctt ccgaagcgaa gcggcgcgcg acggcattgc cgattccgcg gcccgcgccg
    12121 gtaacgatgg ctgttttacc tgctaacttt tgcatgctgc ccacagtaaa cccgtttttc
    12181 acggttccgg caagcttgaa atggacttgg ccgcgcagga acccatacgg ggaaggggcg
    12241 tgccgggaat gaaaaaagag gggggggaga aacggggcgg ggggctactg tccggcctct
    12301 tcattttccc ggagtgcacc ggggggcgcc ccgtcttcat ccggttctac caggtcgctg
    12361 aattcatccg aattttccaa aatgtccttt aaggcggcgg aaccgtaata gcgggcctca
    12421 aacaggcgtt tgccttcctg cctgcagcgg ttgtccagca tttccattcg tttttccatt
    12481 ttttctatca aggcgtcttc tttctccttt tccgcatcgt tcaatttatc ctgaagctgg
    12541 aggaaatgcc ggatgtcctt ctgaatgtcc tgcagcgttt tgacggcgtt gtccgcgctt
    12601 tccttgtcct gaacgcctgc caacgtctgc tggatattga tggcaaagga aaaggcctgg
    12661 ttgatcaggg attccgcgga aggaattttt tccgccggag ccgctgctgc gggggaagcc
    12721 gttccggcgg ccgtttcacc aaatgcaaga gaggctccgg acagaagcgc agaatataag
    12781 agaggaacaa gaaaagcctt catcctgttc ttttaaggca ggatgaaatc cacggcaagg
    12841 aaaaagggga aactgaaaaa agagccttat tccgccgtga tgccgccttt ttcatcgtcc
    12901 agaatgcctg acttttccag atagtagtca tatccacctg cgtaggcggt gatggtcccc
    12961 cggttcacat gcagggtttt ttgtgccagg gaacggatga agtgcacatc gtgggagatg
    13021 aagaccagtg ttccttcata atgcttcaga gcctgcacca gggcttctac ggacaaaagg
    13081 tccaggtggg tggtcggctc gtccatcagc aggaggttgg gcggatccac caggaatttg
    13141 accaggctga gccgcgattt ttccccgccg gaaagaacgc tgacgcgttt ttccacatcc
    13201 agcctccgga acaggaagga acccaggatg gaacgcgctt cttcctcccg gatttcagcg
    13261 ctgcatttca tgatttcctc cagcacggta ttttccggat tcaggttttc cgttcgcgcc
    13321 tgggagaagt agccgatgcg cgtcgtggta ccgggagtgc gttgtccgga gtcaatgggg
    13381 atgatgcccg ccagaatttt gagaagagtg gatttgcccg cgccgttcgg gcctacaaga
    13441 acagtgcgct ccccgcgttc caccagcagg tccaggtttt cataaaccct gcggtcgcca
    13501 taggattggc agactttttc cagctcaatg actttctggg tgctgcgcgg aggctggggg
    13561 aagttgaatt taaatacttt cctgcgggct accggttttt gaatgatttt catcttttcc
    13621 agctgcttga tgcggctctg gacttgcccg gctttggaat tgatggagcg gaaacggtca
    13681 ataaattcct gaatgtgcgc tatttccttc tgctggttgc ggtaggccgc ctgaagctgc
    13741 tcgaagcgca cgtccttttg ttggaggaag tccgagtaat tgccgcggta ttccaccagt
    13801 tcttcgttgt cgatgtcgta cacgctttcc accagctcat ccatgaaatc ccggtcatgg
    13861 gaaatcatca ggatggctcc ggggtagttt ttcaggtatc gctggagcca cagcagggac
    13921 aggaggtcca ggtggttggt aggttcgtcc agcatcagga ggtccggctc caggacaagg
    13981 agcttggcca ggtacgcgcg catgatccag ccgccggaca tttcccgggc ggggcgatgg
    14041 aagtcgcttt cccgaaaggc cagccctttg agaattttct tggctttggg ctccagctgg
    14101 taaccgttgg cggcgttgaa ggtgtcaatg gcttccgcgt attccggcgt atccgttttg
    14161 ttggcgtttt ccgccgtccg gatggtgtgg atggcctgtt ccatttccgg cgtgatgccc
    14221 agggcgattt ccagaacggt ttcatccttc ggttcgctgg cttcctgggg aagatagccc
    14281 acgatggcgt attcatccat gctgatggag ccttcgtccg gcgtgtcttc tcccagaatc
    14341 atgcggaaca gggtggattt gcctgctcca ttggggccaa ccagagccac ccgttccccc
    14401 cagttaatgg tcatttccgt ttccctgaac aaggtccgtc cggcgtggga ttttgtgaga
    14461 tttttgatcg tcagcatggt gaagagagga tgtattctac cgggatggaa aggggaaggc
    14521 aagagccgtc agggcggagg caggcatttt tgaaagcttt actggatttt tacgcgtagt
    14581 ctgctagcct tggcgcgcca tgccgaccac gcagacattc aggcttttgc ttgctgccgc
    14641 ccttttgtgc ggatggagtt cctgctgtac tcctccggcg gaggattata tacaacaacc
    14701 ttacgtgcag cagcaaatgt ccgggctggc taatgccttc ctggcgctgc tgccgccgga
    14761 tcaggcctct cttcccgctg ccggagcgga ggccaggtgg ctggcggaca cggccgtggc
    14821 ccagtccgcc gcgattgccc gggacaacag gactgtgctg tttggctggc tgaacaatat
    14881 tctggtcaat tccaacctgc gcgacagggg gctgtgctgg caggtccagc aggatttgta
    14941 ccgggacctg cgccgccgcc ccgtgaagta tttccgcata gggctgacga ttcgagaccg
    15001 aggaacgggc agggagcaca gttgcgtgta tgtcaatgcc gcggggaagg gattgcaggg
    15061 ctccattgtt ctggatgcct ggaagaactg cgggcatctg gtgacgctga cccagaagga
    15121 ccgggaaggc ggcaaatggg aggaggactg gcgggaacca tttgtttcca aggcctttcc
    15181 ggagggccat tcctacggca tggaacatca cctggtctgg cccgggtggg ccaggaaacg
    15241 ccccatgctg gttcagcgga tattccagtc cgatcagcag aatgaggcga aggcggctgc
    15301 tgaataaagg ggaagcctga tccggcagga accggcacac ggtgctgcgc cgcggcggtt
    15361 tgcggtatcc gccgttttta aggaaaatcc cggcgaatcg gcaaatggcg gagggaatcc
    15421 ggactcaggg caaataaaaa cgcactcagt gcgtacaccg agtgcggatt aattggataa
    15481 tttgctagtg ttgcagggca aaaccccgct gcaaacttac ttgcccttgg cctgcacaac
    15541 cggagcggga gcaggagcgg tggtttgctg ttgctgctgc tgctgggagc aagaagcgac
    15601 caggcaagcg gcgccggcga tggcgaggat agcgatgttc ttcataattc gaattaaata
    15661 cagtgtttgt taactactgg aac
//
