LOCUS       c00053_gnlPro..        13473 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KFFLNLJI_53.
ACCESSION   c00053_gnlPro..
VERSION     c00053_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 10:38:09
            Original ID  :: gnl|Prokka|KFFLNLJI_53
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13473
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13473
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:3473]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..3473
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13473
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13473
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             3..695
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_1"
                     /sec_met_domain="SucD_FumR (E-value: 1.4e-74, bitscore:
                     239.8, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MWLLNSSIGKKLIMSISGLFLVLFLLFHLSMNVAAVFSGEAYNMV
                     CSLLGSNWYAVAATLVLAAGVVIHFVYAIILTLQNRKARGNDRYAINARPKGVEWASQN
                     MFVLGLIVILFMLLHFSQFWYKMMFAELIGHHEVALGSAMVSPQDGAAFINYYFQGNAV
                     ITVLYLIWYVALWFHLTHGFWSAIQTIGWNNTIWMNRWECISKIVATVICGLFAIITII
                     FFLNGVGA"
     CDS             744..2687
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 194.5; E-value:
                     1.1e-59)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 2.5e-60, bitscore:
                     194.5, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-38,
                     bitscore: 122.0, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEINSKIPQGPLAEKWTNYKNHQKLVNPANKRRLDVIVVGTGLA
                     GASAAASLAEMGFNVLNFCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKG
                     GDYRAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQT
                     GQQLLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHA
                     VVVATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVKGDFQSKL
                     TLMSESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDV
                     ASRAAKERCDAGFGVNSTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDNPYE
                     TPMMIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYF
                     VLPYTIQNYLSDQIQVPRFSTDLPEFVEAEKAIKDRIQKLMNVKGKETVDTIHRKLGHI
                     MWEHIGMARDAKGLQEAIQMLKDLKKEFWSNVFIPGNADNLNTELEKALRVADFIEIGT
                     LMAHDALDRAESCGGHFRTEHQTEEGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNY
                     EFVVPQTRNYKK"
     CDS             2718..3473
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg53_3"
                     /sec_met_domain="Fer2_3 (E-value: 1.6e-26, bitscore: 82.5,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 3.1e-12, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 3.3e-06, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDISVTLKVWRQRGPKEKGQFETYKIEKINQSVSFLEMLDILN
                     EQLVNEGKEPIVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFHDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFTSVNTGGVPDANAIPIPKKDADLAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFICAKLQD"
     CDS             complement(3510..3620)
                     /locus_tag="ctg53_4"
                     /transl_table=11
                     /translation="MKKPRCKYTDFSIPVKGYNAKLCFTTYNKNKKAPFF"
     CDS             3896..5107
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg53_5"
                     /sec_met_domain="Radical_SAM (E-value: 6.2e-16, bitscore:
                     49.1, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKRTTSSFRAMSTERKLESIFLFVTGRCNAKCAMCFYAQEMDK
                     KQPDLTFDEIKKISETAGQFNRLWISGGEPTLREDLPEILELFYKNNHIKDVNIPTNGL
                     KPARIVEWVKRFRQNCPDCNINVSLSLDGFGTTHDTQRGVPGNFYKALETLRKIQENFG
                     DDGKVLKNIATVITKYNIDQVEDFMTWVYGRFRTSTHTIEAARGMTRDDGVKILTESTL
                     RKIQDDISPIYSAYADRMVADTTGLRKPITRFFYLGLIRTLYNVRASNIDHPTPWGMDC
                     TAGETTLVIDYDGRFRACELRKPLGNIKEYGCDISKVMNSEAMKQEIAAIGHGYKANCW
                     CTHGCWITSSVIFNPRKMIRSVYKGYRETKRLNHPLAINEQKLQTMEAKYHLDIERLRQ
                     LNIR"
     CDS             5141..6373
                     /locus_tag="ctg53_6"
                     /transl_table=11
                     /translation="MKILLVTRGSQGDVLPYLAIAAELERRGHKVTINLPQIFEETVKP
                     YGFKYVLQQFDDIGGMIDSAAQNSHKFRPFLKWMRNVIDKQFDQLIPLLKEHDILVSTN
                     SEFAVASIAEYCKKPLIRTAYAPFLPGKKIPPAVLPFPKPNPIITPAILWKLMNRMTNF
                     MVKDTINKNRAKYGLAPIRNFGYHAGERSYNYLLFSQHLGNVDPDWTFEWSIGGYCFND
                     TFQYDEKAYEEMISFVDSAQSPIIFFTLGSCSSKDGNRFSKALVDICKKHDYRLIIGSG
                     WAKTGITLQADKHLFLMKQPVPHNLIFPHCDGVIHHGGCGTTHSVGRAGKPQLITPLII
                     DQPYWSYRIHQLGLGPEGVKIAKASEQEIERKVCDLVTNPLYKKNAAHIGEMIQKEGGI
                     KNICDSIERFQ"
     CDS             complement(6388..6480)
                     /locus_tag="ctg53_7"
                     /transl_table=11
                     /translation="MKKPRCKYTELLLFVNGLSAKLCFVTCNKI"
     CDS             complement(6579..9716)
                     /locus_tag="ctg53_8"
                     /transl_table=11
                     /translation="MIRNIINLKAIILYFGLILCLIAGMPTPAYGSSSYPVKEESYVLV
                     INSYVDGERWSGNLLNMISKFATPEEYTLRIDHISVMLVDTPEKLKEKQEVFFEANKKK
                     PDGIIYLGVNGWAFMRDKIREKWGDIPTLVCSETGEMAENECYFNQRHSSDRVIPLQEA
                     VKGYNATGLVIPYYVKGSIDLVKELIPGLKRLIFISDRRYVSTWLRDEMEKHMETSFPE
                     GKVDFYTEGSCSMDSLLAVLSEKDPHRATAVMYYSWITEKPFLNHSLLYSTLYQGINGI
                     SRHPVFSLYDMGVEEGYTIGGYYNSAKTIETALIPLLQQVYNGEDMGKIPVSTVDDPHK
                     YLNYVSLISAISNEDNFPRDAIYLNAPPSFLEKYWMQLLGFLIFFLVVVFLAWHYVYRS
                     KQKMKEVELRLLSRYRDLFNNMPLPYIRQRLIREGTQIDVQVLDVNHAFEEKIAPKDFV
                     VNKHGKEIANLIGGSYPLLLSAVPTVLESGKSFTCEYYFEPTGLYYTIIIMPTSEENVV
                     DAFFIDITDIHKFQTHLKAMNHKLAMALEAADLLPWRYNLAEGKIIYESKVHPGDNIET
                     AEVHTHEVSLKEYFSKIHPSFRACVEKAFDDLCNGKIKKVRKEYCLERLIPGEDRHEWE
                     EIQVMAEYDASGKPKALIGSTISITERKQLEHDLRMARDKAEESNKLKSAFLANMSHEI
                     RTPLNAIVGFSNILASTDDLEDKKEFADIIENNNSLLLQLINDILDLSKIEAGTLEFTY
                     DYVDINAVLRDLEQSAHLKNKNPDVQISFKDYLEPCVIYTDRNRLSQLMINLLNNAMKF
                     TQAGSILFGYKLRDDNTLWFYVEDTGCGIPENKRKDIFGRFVKLNTFAQGTGLGLSICE
                     MIVTQMKGTIGVDSVEGKGSRFWFTLPFQPKKELLPNEEQKPVTLEKIARSEVTILIAE
                     DNSSNYRLFESILKPEYKLIHAWNGKEAVELFHQHKPQLILMDIKMPVMDGYEATAEIR
                     KVSASVPIIAVTAYAFAQDEQRIINSGFDAYTAKPINGKILKDKISTLLTHRIILM"
     CDS             9956..10630
                     /locus_tag="ctg53_9"
                     /transl_table=11
                     /translation="MDMKDYDINFKEKRTNGYLIATLFIIVGILFLLRNLGMIDPSLFD
                     LLVSWPMLLVVSGIFTIFHRNPVGGMLLVGVGVYFLFPQLNWITNDFLRVYWPLGLILL
                     GLVIMLKRKDSIRTKKHKRPFNHPPFGHRKPNDEINYETDNGFVSVDTTFNSVRHIVLD
                     PVFKGADIDVSFGNVILDLKKTTLEADETIINIDSSFSGVVIYVPKGWLVRLKVGSFLA
                     GC"
     CDS             10731..11525
                     /locus_tag="ctg53_10"
                     /transl_table=11
                     /translation="MQEHPITTSILHKGLGSLLLLLAIAIQCALLTLYGDLPLSITLID
                     SLLSIALFAVAGYYLWYVQCTLHIMQARVAFAVLVQIACIAGCSILLQIFGLEDWEEFS
                     ITIPFRFLFGLMAWIILSQWYASRERKSEAEPIVRQMEEKTAPPPTTVPEEILDRISVK
                     DGARIHIIPIKEIFYLQACGDYVTLFTTSGQHVKEQTMKYFERSLPSPEFVRIHRSYIV
                     NTEQILRVELFGKETYQVRLKDGTYLRASSAGYKLLKERLSL"
     CDS             complement(11863..12381)
                     /locus_tag="ctg53_11"
                     /transl_table=11
                     /translation="MKKYWHIALMLFCVFMITSCGDDDEALEVDEVWKVQNEEAFQAQM
                     LVPGFEQLSSQSNAGFILYKVLKTGESKEPIYYTSKVECYYKGTFIDGTVFDDKSFEAG
                     APAELTVSEMVDGFATALQNMHPGDRWEIWIPQQMGYGSAGRSASGSVIIKPYTTLIFD
                     LEVTRIVKE"
ORIGIN
        1 ttatgtggtt acttaattct tctatcggga agaagctgat aatgagtata tcaggcctct
       61 ttcttgttct gttcttattg ttccacctgt cgatgaacgt ggcggccgtt ttctccggag
      121 aggcttataa catggtttgt tcgctgttgg gctctaattg gtacgctgtg gcagctactc
      181 tcgtattggc cgcaggcgtt gtgatccact tcgtgtacgc tatcattctt accttgcaaa
      241 accgtaaggc acgtggtaac gaccgttacg ctatcaacgc tcgtccgaaa ggcgtggaat
      301 gggcatctca gaacatgttc gttttgggtt tgatcgttat cctgttcatg ctgttgcact
      361 tcagccagtt ctggtataag atgatgttcg ccgaattgat cggtcatcac gaagtagcat
      421 tggggtcagc tatggtatct ccacaagacg gagccgcttt tatcaactat tacttccaag
      481 gtaatgccgt gatcaccgtt ctttatttga tctggtacgt ggctttgtgg ttccacttga
      541 ctcacgggtt ctggagcgct atccaaacaa ttggttggaa taatacgatc tggatgaacc
      601 gttgggaatg tatctctaag atcgtagcta cggttatttg cggacttttc gcgatcatta
      661 ctatcatctt cttcctaaac ggagtaggtg cttaattgca agctacaggt tttataatta
      721 agaacttttg aaattaaatc attatgtctg aaataaattc taaaatacct caaggcccgt
      781 tggctgagaa gtggactaat tataaaaatc accagaaatt ggtgaacccc gctaacaagc
      841 gtcgtttgga tgttatcgta gtcggtacag gtttggccgg agcttccgct gccgcatctt
      901 tggcagagat gggattcaac gtattgaact tctgtatcca agattctccc cgccgtgcgc
      961 actctatcgc cgctcaaggt ggtatcaacg ccgctaagaa ctaccagaat gatggtgact
     1021 ctgtttaccg tttgttctac gatacgatca aaggtggtga ctaccgtgct cgtgaggcta
     1081 acgtttatcg tttggctgag gtttctaact caatcatcga ccagtgcgtg gctcaaggcg
     1141 ttcctttcgc tcgcgaatat ggtggtttgt tggataaccg ttcattcggt ggcgctcagg
     1201 tatcgcgtac gttctacgcc cgtggccaga cgggtcagca gcttttgtta ggcgcttatt
     1261 cagcgttgag ccgtcagatc ggtttgggta aggttaagat gtacactcgt catgagatgt
     1321 tggatgtagt taaggtagac ggtcgtgctc gtggtatcat cgcccgcaac ttgattacag
     1381 gtaagatcga gcgttacgcc gctcacgctg tagttgtagc tacgggtggt tacgttaata
     1441 cgttcttctt gtcaaccaac gctatggcat ctaacggttc cgccgcatgg caatgctaca
     1501 agaaaggcgc ttacttcgct aatccttgta tggttcagat ccacccgact tgcgtaccgg
     1561 tgaaaggtga cttccaatct aaattgactt tgatgtccga atccttgcgt aacgacggcc
     1621 gtatctgggt tccgaagaaa ctggaagacg ctaaagctct acaggccgga acgaagaaag
     1681 gtaaagatat tcccgaggca gaccgtgatt attatttgga gcgtcgttat ccggcattcg
     1741 gaaacttggt tcctcgcgac gtggcttctc gtgccgctaa agagcgttgc gacgcaggtt
     1801 tcggcgtgaa cagcacgggc ttggccgtat tcttggattt ctccgacgcg atcaatcgct
     1861 tgggtaaaga ggtcgttaag cagaaatacg gtaacttgtt cgatatgtac gaagagatca
     1921 cgaacgataa tccatacgag actccgatga tgatctaccc ggcattgcac tactcaatgg
     1981 gtggattgtg ggttgactat gagttgatga cctccattcc gggtctgttc gctatcggtg
     2041 aggcaaactt ctccgatcac ggagcgaacc gtttaggtgc ttccgctttg atgcagggat
     2101 tggccgatgg ttatttcgta ttaccataca cgatccagaa ctatttgtcc gaccaaatcc
     2161 aagttcctcg cttcagcacg gatctgccgg agttcgtcga ggcagaaaag gccatcaagg
     2221 atcgtatcca aaaattgatg aacgtcaagg gtaaagaaac cgtagacact atccaccgca
     2281 aactaggtca tatcatgtgg gaacatatcg gtatggcacg cgacgcaaaa ggtttgcaag
     2341 aagctatcca gatgctgaaa gacttgaaga aagagttctg gagcaacgta ttcatcccag
     2401 gcaacgcaga caacttgaat accgagttag agaaagcatt acgtgtagcc gactttatcg
     2461 agatcggtac attgatggca cacgatgctt tggaccgcgc tgagtcttgt ggtggtcact
     2521 tccgtacgga gcaccagaca gaagaaggtg aggccttgcg tcatgacgat aagttcatgt
     2581 acgtatcttg ctgggagtac caaggcgagg acaaagatcc tgtcatgttg aaagaggatt
     2641 tgaactatga gttcgttgtt cctcaaacac gtaactacaa gaagtaataa tcatcaatct
     2701 cagaaaaaat tagaatcatg gataaagata taagtgtaac acttaaggtt tggcgtcaga
     2761 gaggtccgaa ggagaaagga cagttcgaga catacaaaat tgagaagatc aatcagagtg
     2821 tctctttctt ggaaatgttg gatatcttga acgagcagtt ggtcaacgag ggtaaggaac
     2881 cgatcgtatt cgatcacgac tgccgcgagg gtatctgtgg catgtgttca ttgtatgtaa
     2941 acggacaccc gcacggaccg gcaactggag ctacgacttg ccagttatat atgcgtcgtt
     3001 tccacgatgg agagacgatc acgatcgaac cgtggcgttc cgcaggtttc cctgttatcc
     3061 gcgacttgat ggtagaccgc tacgcttacg acaaaatcat ccaagcgggt ggtttcacat
     3121 ctgtcaacac aggtggtgta cccgacgcta atgcgatacc tatcccaaag aaggacgcag
     3181 acttagccat ggacgctgcc gcttgtatcg gttgtggcgc ttgtgctgcc gcttgtaaga
     3241 atggttccgc tatgttattc gtatccgcta aggttagcca gctggctttg ttgcctcaag
     3301 gtaaagtcga ggctgctcgc cgtgccaaag ctatggtcgc taaaatggat gagcttggct
     3361 tcggtaactg tacgaacaca cgtgcttgcg agatggaatg tccgaagaat atctccgtta
     3421 gcaacatcgc tcgtttgaac cgcgagttca tttgcgctaa attacaagac taatatttga
     3481 ttagtatatc atggaaaagg cgtctttctc taaaagaaag gcgccttttt gtttttgtta
     3541 tatgtcgtaa aacataattt agcattatag cccttgacag gaattgaaaa gtccgtatat
     3601 ttgcatcgtg gttttttcat aatagtatta gatttaaggt taacaaagtt tggttagggc
     3661 ttgtcgtgag acaggcttta attgtttata gacctacctt ttaaacatgg accataaaat
     3721 actgcaaata gagattgttt agcgtcattt tatcgtcgat ctttgccttt aaagatcata
     3781 tagtatatgc taataagtat tttatttggc ttcttatgtt attttctccg ggtgttgatc
     3841 aaacacaagg aaaaaatcat gcgccagata agacaaatgg taaaacaaaa ataaaatgga
     3901 caaaaaacga accaccagtt ctttcagggc aatgagcacg gaaagaaaac tcgagtcgat
     3961 cttccttttc gtaacaggcc gatgcaacgc caaatgcgcg atgtgtttct atgcccaaga
     4021 aatggataag aagcaacccg acctcacttt cgatgaaatc aagaagatat cagaaaccgc
     4081 cgggcaattc aaccgattat ggatatccgg aggtgagcct accctgcgtg aggatctacc
     4141 ggaaatattg gagttattct acaaaaacaa ccatatcaaa gatgtgaaca tccctacgaa
     4201 cggcttaaaa ccagcccgga tcgtcgaatg ggtaaaacgg ttccgccaga actgcccgga
     4261 ttgtaatatt aacgtaagcc tttccttgga tggtttcggt acgacccacg atacacagag
     4321 aggcgtaccg ggaaacttct ataaggcctt ggaaaccctg cgtaagatac aggagaattt
     4381 cggagacgac ggcaaggtcc tgaaaaatat agcaaccgtt atcacgaaat acaatataga
     4441 ccaggtagaa gacttcatga cttgggtata cggacgtttc cgcacctcca cgcatacgat
     4501 tgaggccgcc agaggcatga cccgtgacga tggcgtgaaa atcctaaccg agtcaacgct
     4561 acgcaaaata caagacgaca tatcccctat ctattctgct tatgcggatc ggatggtagc
     4621 ggataccacc ggcttaagga aaccgatcac acgcttcttc tatctcggcc ttatacgtac
     4681 cttatataat gtgcgtgcca gcaacataga tcacccgacc ccttggggga tggattgtac
     4741 ggccggagag actaccttgg taatcgacta cgacggacgt tttcgtgcct gcgagctacg
     4801 gaaaccgctc ggaaatataa aagagtatgg ttgcgatata agtaaagtga tgaatagcga
     4861 agcgatgaaa caggaaatag ccgctatcgg acatgggtat aaagccaact gttggtgtac
     4921 gcacggctgc tggatcacct catccgtcat tttcaatcca cgtaagatga ttcgctccgt
     4981 atataaagga taccgggaaa cgaaacgatt gaatcatccc ctagccatca atgagcagaa
     5041 actacaaacg atggaagcca aataccatct ggacatcgag cgtttgcgtc aactgaatat
     5101 ccggtgaaca agaccctcat agcccataaa taaacgtagc atgaaaatac tattagtaac
     5161 cagaggctca caaggcgacg tccttcctta tttggccata gcggccgaat tggaaagacg
     5221 tggccataag gtgaccatca atctccctca aatattcgag gagaccgtta aaccctacgg
     5281 atttaaatac gtattgcagc agtttgacga tatcggcggc atgatcgata gcgcagcgca
     5341 aaactcacat aaattccggc cattccttaa atggatgagg aacgtgatcg ataaacagtt
     5401 cgatcaattg attcccctac taaaagagca tgatatttta gtatcgacca actcggaatt
     5461 tgctgtcgca agtatcgccg agtattgcaa gaagcccttg atacgtaccg cctacgcccc
     5521 gttcttgccg ggtaagaaga ttcccccggc cgtattgcca tttcccaaac ccaacccgat
     5581 catcacccct gccatcctat ggaagttgat gaaccggatg accaatttca tggtcaaaga
     5641 cacgatcaac aagaaccggg ctaaatacgg actcgctccg atccgcaatt ttggctatca
     5701 cgcgggagag cgttcatata attacttgct tttcagccag cacctaggaa acgtagatcc
     5761 ggactggacg ttcgaatggt cgatcggagg ctattgcttc aatgacactt ttcaatatga
     5821 tgagaaggct tacgaggaaa tgatatcatt cgtcgacagc gctcaaagcc ctattatctt
     5881 ttttaccctc gggagttgta gttccaagga tggtaaccgt ttcagcaaag ccttggtcga
     5941 tatttgcaag aaacatgatt atcggctcat catcggttcc ggttgggcaa agacaggaat
     6001 caccttacaa gcggataaac atttattctt aatgaagcag ccggttccgc ataatttgat
     6061 attcccgcac tgcgacggcg ttatccatca tggaggttgc ggcacgaccc atagcgtagg
     6121 aagggcggga aagccccaat taatcactcc gttgattatc gatcaaccct attggtccta
     6181 tcgaatccac caattagggt tagggccgga aggggttaag atagcgaaag cgagcgagca
     6241 ggagatcgaa cgcaaggttt gtgatctggt caccaatccg ctttataaga aaaatgccgc
     6301 tcatataggc gagatgatcc aaaaagaggg aggtataaag aatatatgcg actctatcga
     6361 aagatttcaa tgaggcataa gttcctatta gattttatta catgttacaa aacacaattt
     6421 agcacttaaa ccattgacaa ataacagtaa ctccgtatat ttgcatcgtg gttttttcat
     6481 aatagtatta gatttaaggt taacaaagtt tggttagggc ttgtcgtgag acaggcttta
     6541 attgttttat aaggtctgct tcccgcaaag cccttcgatt acatcagaat aatccgatgc
     6601 gtcaataaag ttgatatctt gtcttttaag atcttcccat taatcggttt cgccgtatag
     6661 gcatcaaatc cactattaat gatccgttgc tcatcttggg cgaaagcata agccgtcacc
     6721 gcaataatag gcacgctagc agaaacctta cgaatctctg cggtagcctc gtatccatcc
     6781 atgaccggca tctttatatc catcaagatc aactgcggtt tgtgctgatg aaatagctcc
     6841 acagcctcct ttccattcca tgcatgaatc aatttatatt caggtttcaa tatagactca
     6901 aacaggcgat aattactgga attatcctca gcgatcaaga tcgtaacctc acttcgggcg
     6961 atcttctcca aagtaacagg cttctgctct tcattaggca ataattcttt cttcggctga
     7021 aaaggcaatg taaaccagaa cctagagcct ttcccttcca cggaatcaac ccctatcgtt
     7081 cctttcatct gggtaacaat catctcacag atgcttaaac ccaatcctgt tccttgagcg
     7141 aaagtattca gtttcacaaa acgtccgaaa atatctttcc gtttattctc cgggattccg
     7201 cagcccgtat cctctacata gaaccacaac gtattatcat cccgcagttt atagccaaat
     7261 aagatcgatc ctgcctgcgt aaatttcatg gcattgttca acagattgat catcagttga
     7321 gacagacgat ttcgatccgt ataaatcacg caaggctcca gataatcctt aaatgagatc
     7381 tgtacatccg gattcttatt cttcaaatga gccgattgct ccaaatccct caatacagcg
     7441 ttaatatcca catagtcata agtaaactcc aaggtacccg cctcaatctt tgacaaatcc
     7501 aagatatcgt ttatcaactg caacaatagg gaattattat tctcgataat atcagcgaat
     7561 tccttcttat cctcaaggtc atcggtcgag gcaaggatat tagagaaacc tacgatcgca
     7621 tttaacggtg tacgtatctc atggctcata tttgctaaaa acgctgattt caatttattc
     7681 gactcttccg ccttatccct agccattcga aggtcatgtt ccaattgctt acgctcggta
     7741 atagatatcg tagacccgat caacgctttc ggtttaccgg aagcatcata ttcggccatt
     7801 acctgtatct cctcccactc atggcgatct tctcccggaa tcaaccgctc cagacaatat
     7861 tcttttcgta ctttctttat tttcccatta cacaaatcat cgaaagcctt ttccacgcaa
     7921 gccctgaaag acgggtgtat cttgctgaaa tattccttca acgaaacctc atgggtatgc
     7981 acctccgctg tctctatatt atctcccgga tgtactttcg actcatagat aatcttccct
     8041 tcagccagat tatatcgcca cggtaaaaga tctgccgcct ctaacgccat agccagctta
     8101 tgattcatgg ctttcaaatg cgtctggaat ttatggatat ccgtaatatc aataaaaaac
     8161 gcatcaacca cattctcttc cgaggtaggc atgatgataa tcgtatagta aagccctgtc
     8221 ggctcaaaat aatactcaca agtaaaggat ttcccactct ccagaactgt aggtacagcc
     8281 gatagaagca aaggataact tcccccaatt aaattagcga tctcttttcc atgcttattt
     8341 accacgaaat ctttaggagc gattttttcc tcgaaagcat ggtttacatc caaaacctgc
     8401 acatcgattt gcgtaccttc ccgaatcagc cgctgccgta tataaggcaa tggcatatta
     8461 ttaaataaat cacggtaacg ggataatagc ctcaactcca cttccttcat cttttgctta
     8521 gaacgataca cgtaatgcca cgctaaaaac acgactacca gaaagaatat cagaaagcct
     8581 aacagttgca tccaatattt ttccaagaaa gagggaggcg cattcaagta gatcgcatca
     8641 cgcgggaaat tatcttcatt agatatcgca cttatcaacg aaacataatt caagtattta
     8701 tgaggatcat ccaccgttga aaccgggatc ttgcccatat cttcaccgtt ataaacttgt
     8761 tgtagcaagg ggattagagc agtctcaatc gttttagcgc tattataata tccaccaatc
     8821 gtatatcctt cttccacacc catatcatat aaagaaaaaa caggatgcct agaaataccg
     8881 tttatacctt gatataaagt actatataat aacgagtgat tcaagaaagg tttctcggta
     8941 atccacgagt aatacatcac ggctgtcgct cgatgcggat ctttctccga cagaaccgcc
     9001 aataaactat ccatggagca agaaccctcc gtataaaaat ccactttccc ctcagggaaa
     9061 gaagtttcca tatgtttctc catctcatcc cggagccatg tggaaacata acgtctgtcg
     9121 gatatgaaaa tcagacgttt caaacccggg attaattcct tcaccaagtc gatcgaacct
     9181 ttaacataat aagggataac caatcccgta gcgttatacc ccttaaccgc ctcttgtaaa
     9241 ggaatcaccc tatcagagga atgcctctga ttaaaataac attcattttc tgccatttcc
     9301 cccgtctccg aacagaccag agtgggaata tccccccatt tctcccggat cttatcccgc
     9361 ataaaagccc atccatttac gcctaagtag ataattccat ccggcttctt cttgttagct
     9421 tcaaagaaga cctcttgttt ctcttttaat ttctctggcg tatcaaccaa catcacgctt
     9481 atatgatcta tccggagagt gtactcctcc ggggtagcga acttcgagat catgtttaat
     9541 aaattaccag accaacgttc gccatccaca tatgaattta tcaccaatac atacgattcc
     9601 tccttgaccg gatatgaaga actcccataa gccggagtcg gcataccggc tatcaagcat
     9661 aaaatcaatc caaaataaag tattattgcc tttaaattta taatatttcg tatcattccc
     9721 tacattcctc tattgcagtt gtaaagacaa agatattcct taattatcaa ctaatcttat
     9781 caaactagtt tttttatcaa gttttggtgt caaattcacg tttcttacaa actaaaggct
     9841 tttttaatcg ggattattcg gttatttacc gatactcgta tagaaatcag cggtatttac
     9901 ttgtgtatag aatgacgaac ccgtacattt gataaaaaac aaaaaaattg aacttatgga
     9961 tatgaaagat tatgacatca attttaaaga gaagaggaca aacgggtatc tgatcgctac
    10021 cttatttatc attgtcggta tattattttt actgcggaat ctaggaatga tagatccatc
    10081 cttatttgac ttgcttgtat cttggccgat gctgcttgtc gtgtcgggca tctttacgat
    10141 tttccaccgt aatccggtag gaggtatgct cctcgtgggc gtgggagtct atttcctttt
    10201 cccgcagtta aattggatca cgaacgattt tttacgtgta tattggccgt taggattaat
    10261 cctgttagga ttggtcatca tgctgaagcg gaaagattct atccgcacga aaaagcataa
    10321 acgtcccttt aaccatcccc ctttcgggca cagaaagcct aacgatgaga tcaactacga
    10381 gacagataac ggtttcgtat cggttgacac cactttcaac tcggtaaggc acatcgtact
    10441 ggaccccgta ttcaaggggg cggacataga cgtatctttc ggcaacgtga ttcttgatct
    10501 taaaaaaaca acattagagg ctgatgaaac catcataaac atagatagct ccttcagcgg
    10561 cgtagtaata tacgttccta aaggatggct ggttcgtcta aaggttggtt ctttcttggc
    10621 aggatgctaa gatatgaggg aactgacaga agcaaccgac atgacgcata cactatacat
    10681 atgtggagac ttgtcgttca gcggccttga actaagagac taaactcatc atgcaagaac
    10741 atcctattac aacatccata ttacataaag ggctgggaag cctattatta cttttagcca
    10801 tagcgatcca atgcgcatta ttaactcttt atggcgatct tccgttgagc atcactttga
    10861 tcgatagctt actttccatc gcattgttcg ccgtagcggg atattatctt tggtatgtac
    10921 aatgtacgtt acatatcatg caagcacgag tggctttcgc cgtactcgta caaatcgctt
    10981 gcatagccgg atgctcgatc ttgctacaaa tattcggatt ggaagattgg gaggaattct
    11041 cgatcacgat tccttttcga ttcctgttcg gcctaatggc atggatcatt ctatcccaat
    11101 ggtatgccag tcgggaaaga aagagtgagg cggaacctat cgtgagacaa atggaggaaa
    11161 agacggcacc tcccccgact accgttccgg aggagattct agatcgtata tccgtaaaag
    11221 acggggcacg tattcatatc atcccgataa aagagatatt ctatttgcaa gcatgtggcg
    11281 actatgtgac cttattcacc acttccggtc agcacgtaaa ggagcaaacc atgaagtatt
    11341 tcgagcgaag ccttccttct ccggagttcg ttcgtataca ccgctcttat atcgttaata
    11401 cggaacagat attgcgagta gaactattcg gaaaagaaac ctatcaagta cgattaaagg
    11461 atggaacata tcttcgtgcc agtagcgctg gctataagct actcaaagaa cgtctttccc
    11521 tttagcagtc ctataaaagg gacctaatca tcgttaaaat tagaagattt tgattgtaat
    11581 atatagagtt ttgtgttgtg taacactttt tggcaagcat agatatgtta cttaacatat
    11641 attagttgca aaagacttga caaatggtct tgacgaacgt atctttgcac cgtggttttt
    11701 tcataatagt attagattta aggttaacaa agtttggtta gggcttgtcg tgagacaggc
    11761 tttaattgtt tatagaggtt tgcttcccta gatttacata taactataaa aaaacggcca
    11821 cccctaaaaa gaggcggccg taattattct taatgaaaga acctactctt tgacaatcct
    11881 tgtaacttcc aaatcaaaga tcaaagtcgt ataaggcttt attatgacac ttcccgaagc
    11941 actccttcca gccgaaccgt atcccatctg ttgaggaatc caaatctccc aacgatctcc
    12001 tgggtgcata ttctgtaacg ctgtagcaaa accatctacc atctcagaaa cagtaagttc
    12061 ggcaggggca cctgcctcaa acgatttatc atcaaaaacc gttccatcaa taaacgtccc
    12121 tttataataa cattccacct tgctcgtata ataaatcggc tccttactct ctcctgtctt
    12181 caagaccttg taaaggataa atccggcatt actttgagaa ctcaattgct cgaaacccgg
    12241 aaccagcatc tgggcttgaa aagcctcctc attctggacc ttccaaacct catccacctc
    12301 tagtgcctca tcatcatccc cacaagaggt gatcatgaac acgcaaaaca acatcaacgc
    12361 gatatgccag tacttcttca ttcgtttact ctattacctt tttcaataaa ttcttcatgc
    12421 tcaccttctc cgtgataata tcgtgaagct tatcgatgct tacgcgctct tgctccatcg
    12481 tgtcacggaa acggatcgtt acgcaattat ccttcaaggt gtcatggtct accgtaatac
    12541 aatacggggt accgatcgca tcctgacggc gataacgctt accaatagaa tccttctcgt
    12601 cgtattggca acggaagtcg aaacgcaaca tatttataat ctcctcagct ttctcgggca
    12661 ggccatcttt cttcaccaat ggcaatacgg ccaacttgat cggagccaag gctgcgggca
    12721 acttcaatac cacacggctc tcgccattcg ccaatgtctc ctcgcagtaa gaacccgcca
    12781 tgatgctcaa gaacacacgg tctacaccga tcgaggtctc gattacatac ggagtgtaac
    12841 tctggttcaa ctccggatcg aaatattgga tctttttacc ggaaaacttc tcatgctgac
    12901 tcaagtcgaa attcgtacgg ctatgtatac cctccacttc cttgaatccg aacggcatct
    12961 cgaactcgat atccgtagcg gcgttagcgt agtgagccaa cttctcatga tcgtgataac
    13021 gatacttctg atctcccaag ccaagagctt gatgccattt taagcgagta gacttccatt
    13081 tcttgaacca ctcgatctcc tcacccggac gaacgaagaa ttgcatctcc atttgctcga
    13141 actcgcgcat acggaagata aactgacgag ccacgatctc attacggaac gccttaccga
    13201 tctgggcgat accgaacggg atcttcatac ggccagtctt ctgcacattc aagaagttca
    13261 cgaaaatacc ttgagccgtc tccggacgaa gataaatctt agtcgctcca tcagcggtag
    13321 aacccatatc cgtagagaac atcaagttaa actggcgaac ctccgtccag ttacgagttc
    13381 cggaaatcgg gcaaacgatc tcgcaatcca agatcaattg gcgaagatcc tcgaagttag
    13441 actcgttcat cgccttgcta taacgctcat gga
//
