LOCUS       c00025_gnlPro..        11572 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|EIICDHFA_25.
ACCESSION   c00025_gnlPro..
VERSION     c00025_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 14:47:41
            Original ID  :: gnl|Prokka|EIICDHFA_25
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11572
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11572
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2:2540]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3..2540
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..11572
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11572
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             3..1760
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 164.9; E-value:
                     1.1e-50)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_1"
                     /sec_met_domain="FAD_binding_2 (E-value: 1.6e-51, bitscore:
                     164.9, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 5.4e-39,
                     bitscore: 122.4, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="FCIQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRLFYDTIKGGDY
                     RAREANVYRLAEVSNSIIDQCVAQGVPFAREYGGLLDNRSFGGAQVSRTFYARGQTGQQ
                     LLLGAYSALSRQIGLGKVKMYTRHEMLDVVKVDGRARGIIARNLITGKIERYAAHAVVV
                     ATGGYVNTFFLSTNAMASNGSAAWQCYKKGAYFANPCMVQIHPTCVPVHGDYQSKLTLM
                     SESLRNDGRIWVPKKLEDAKALQAGTKKGKDIPEADRDYYLERRYPAFGNLVPRDVASR
                     AAKERCDAGFGVNNTGLAVFLDFSDAINRLGKEVVKQKYGNLFDMYEEITNDDPYETPM
                     MIYPALHYSMGGLWVDYELMTSIPGLFAIGEANFSDHGANRLGASALMQGLADGYFVLP
                     YTIQNYLSDQIQVPRFSTDLPEFNEAEKNIQARINKLMSIKGKESVDSIHKRLGHIMWE
                     HIGMARNAESLKEAIQMLKDLKKEFWSNVFIPGNADDLNVELEKALRLADFIEIGTLMA
                     HDALDRAESCGGHFREEHQTEEGEALRHDDKFMYVSCWEYQGEDKDPVMLKEDLNYEFV
                     VPQTRNYKK"
     CDS             1785..2540
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg25_2"
                     /sec_met_domain="Fer2_3 (E-value: 5.7e-26, bitscore: 80.0,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 2e-12, bitscore: 36.8,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.1e-06, bitscore: 17.5,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKDINITLKVWRQKGPNVKGQFETYQLKNINQGTSFLEMLDILN
                     EQLISEGKEPVVFDHDCREGICGMCSLYVNGHPHGPATGATTCQLYMRRFNDGETITIE
                     PWRSAGFPVIRDLMVDRYAYDKIIQAGGFTSVNTGGVPDANAIPIPKPDAEMAMDAAAC
                     IGCGACAAACKNGSAMLFVSAKVSQLALLPQGKVEAARRAKAMVAKMDELGFGNCTNTR
                     ACEMECPKNISVSNIARLNREFICAKLQD"
     CDS             2963..4174
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Radical_SAM"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg25_3"
                     /sec_met_domain="Radical_SAM (E-value: 8.1e-17, bitscore:
                     51.4, seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKKRTTSSFRAMSTERKLESIFLFVTGRCNAKCAMCFYAQEMDK
                     KQPDLTFDEIKKISETAGQFNRLWISGGEPTLREDLPEILELFYKNNHIKDVNIPTNGL
                     KPDRIVEWVKRFRQNCPDCNINVSLSLDGFGTTHDTQRGVPGNFYKALETLRKIQENFG
                     DDGKVLKNIATVITKYNIDQVEDFMTWVYGRFRTSTHTIEAARGMTRDDGVKILTESTL
                     RKIQDDISPIYSAYADRMVADTTGLRKPITRFFYLGLIRTLYNIRASNIDHPTPWGMDC
                     TAGETTLVIDYDGRFRACELREPLGNIKEYGCDISKVMNSEAMKQEIAAIGHGYKANCW
                     CTHGCWITSSVIFNPRKMIRSVYKGYRETKRLNHPLAINEQKLQTMEAKYHLDIERLRQ
                     LNIR"
     CDS             4208..5440
                     /locus_tag="ctg25_4"
                     /transl_table=11
                     /translation="MKILLVTRGSQGDVLPYLAIAAELGRRGHEVTINLPQIFEETVKP
                     YGFKYVLQQFDDIGGMIDSAAQNSHKFRPFLKWMRNVIDKQFDQLIPLLKEHDILVSTN
                     SEFAVASIAEYCKKPLIRTAYAPFLPGKKIPPAVLPFPKPNPIITPAILWKLMNRMTNF
                     MVKDTINKNRAKYGLAPIRNFGYHAGERSYNYLLFSQHLGNVDPDWTFEWSIGGYCFND
                     TFQYDEKAYEEMISFVDSAQSPIIFFTLGSCSSKDGNRFSKALVDICKKHDYRLIIGSG
                     WAKTGITLQADKHLFLMKQPVPHNLIFPHCDGVIHHGGCGTTHSVGRAGKPQLITPLII
                     DQPYWSYRIHQLGLGPEGVKIAKASEQEIERKVCDLVTNPLYKKNAAHIGEMIQKEGGI
                     KNICDSIERFQ"
     CDS             complement(5646..8783)
                     /locus_tag="ctg25_5"
                     /transl_table=11
                     /translation="MIRNIINLKAIILYFGLILCLIAGMPTPAYGSFSYPVKDESYVLV
                     INSYVDGERWSGNLLNMISKFATPEEYTLRIDHMSVMLVDTPEKLKEKQEAFFEVNKKK
                     PDGIIYLGVNGWAFMRDKIREKWGDIPTLVCSETGEMAEDECYFNQRHSSDRVIPLQEA
                     VKGYNATGLVIPYYVKGSIDLVKELIPGLRRLIFISDRRYVSTWLRDEMEKHMETSFPE
                     GKVDFYTEGSCSMDSLMAVLSEKDPHRATAVMYYSWITEKPFLNHSLLYSTLYQGINGI
                     SRHPVFSLYDMGVEEGYTIGGYYNSAKTIETALIPLLQQVYNGEDMGKIPVSTVNDPHK
                     YLNYASLISAISNEDNFPRDAIYLNAPPSFLEKYWMQLLGFLIFFLVVVFLAGHYVYRS
                     KQKMKEVELRLLSRYRDLFNNMPLPYIRQRLIREGTQIDVQVLDVNHAFEEKIAPKDFV
                     VNKRGKEIANLIGGSYPLLLSAVPTVLESGKSFTYEYYFEPTGLYYTIIIMPTSEENVV
                     DAFFIDITDIHKFQTHLKAMNHKLAMALEAADLLPWRYNLAEGKIIYESKVHPEDNIET
                     AEIHTHEVSLEEYFSKIHPSFRACVEKAFDDLCNGKIKKVRKEYCLERLIPGEDRHEWE
                     EIQVMAEYDASGKPKALIGSTISITERKQLEHDLRMARDKAEESNKLKSAFLANMSHEI
                     RTPLNAIVGFSNILASTDDLEDKKEFADIIENNNSLLLQLINDILDLSKIEAGTLEFTY
                     DYVDINAVLRDLEQSAHLKNKNPDVQISFKDYLEPCVIYTDRNRLSQLMINLLNNAMKF
                     TQAGSILFGYKLKDDNTLWFYVEDTGCGIPENKRKDIFGRFVKLNTFAQGTGLGLSICE
                     MIVTQMKGMIGVDSVEGKGSRFWFTLPFQPKKELLPSEEPKPVTLDKIARNELTILIAE
                     DNSSNYRLFESILKPEYKLIHAWNGKEAVELFHRHKPQLILMDIKMPVMDGYEATAEIR
                     KVSSNVPIIAVTAYAFAQDEQRIIKSGFDAYTAKPINGKVLKDKISTLLTHRIILM"
     CDS             9013..9789
                     /locus_tag="ctg25_6"
                     /transl_table=11
                     /translation="MELMDMKDYDIDFKEKRTNGYLIATLFIIVGILFLLRNLGMIDPS
                     LFDLLVSWPMLLVVSGIFTIFHRNPVGGMLLVGVGVYFLFPQLNWITNDFLRVYWPLGL
                     ILLGLVIMLKRKDSIRTKKHKRPFNHPPFGHRKPNDEINYETDNGFVSVDTTFNSVRHI
                     VLDPVFKGADIDVSFGNVILDLKKTTLEADETIINIDSSFSGVVIYVPKGWLVRLKVDS
                     FLAGCQDMRDLTETTDMTHTLYICGDLSFSGLELRD"
     CDS             9797..10591
                     /locus_tag="ctg25_7"
                     /transl_table=11
                     /translation="MQEHPITTSILHKGQGSLLLLLAIAIQCALLTLYGDLPLSITLVD
                     SLLSIALFAVAGYYLWYVQCTLHIMQARVAFAVLVQIACIAGCSILLQIFGLEDWEEFS
                     ITIPFRFLFGLMAWIILSQWYASRERKSEAEPIVRQMEEKTAPPPTTVPEEILDRISVK
                     DGTRIHIIPIKEIFYLQACGDYVTLFTTSGQHVKEQTMKYFERSLPSPEFVRIHRSYIV
                     NTEQILRVELFGKETYQVRLKDGTYLRASSAGYKLLKERLSL"
     CDS             complement(10931..11455)
                     /locus_tag="ctg25_8"
                     /transl_table=11
                     /translation="MKKYWHIALMLFCVLMITSCGDDDEALEVDEVWKVQNEEAFQAQM
                     LVPGFEQLSSQSNAGFILYKVLKTGESKEPIYYTSKVECYYKGSFINGEVFDDRSFEAG
                     EPAVMEVYKMTDGFATALQNMHPGDKWEIWVPSQLGYGEAGYKNPNTGAVVVKPCTTMI
                     FEMEVVGIVEE"
     CDS             complement(11460..11570)
                     /locus_tag="ctg25_9"
                     /transl_table=11
                     /translation="IRFRDTMEQERISIDKLHDIITEKVSMKNLLKKVIE"
ORIGIN
        1 acttctgtat ccaagattct ccccgccgtg cgcactctat cgccgctcaa ggtggtatca
       61 acgccgctaa gaactaccag aatgatggtg actctgttta ccgtttgttc tacgatacga
      121 tcaaaggtgg tgactaccgt gctcgtgagg ctaacgttta tcgtttggct gaggtttcta
      181 actcaatcat cgaccagtgc gtggctcaag gcgttccttt cgctcgcgaa tatggtggtt
      241 tgttggataa ccgttcattc ggtggcgctc aggtatcgcg tacgttctac gcccgtggcc
      301 agacgggtca gcagcttttg ttaggcgctt attcagcgtt gagtcgtcag atcggtttgg
      361 gtaaggttaa gatgtacact cgtcatgaga tgttggatgt agttaaggta gacggtcgtg
      421 ctcgtggtat catcgcccgc aacttgatta caggtaagat cgagcgttac gccgctcacg
      481 ctgtagttgt agctacgggt ggttacgtta atacgttctt cttgtcaacc aacgctatgg
      541 catctaacgg ttccgccgca tggcaatgct acaagaaagg cgcttacttc gctaatcctt
      601 gtatggttca gatccacccg acttgcgttc cggtacacgg tgattatcag tctaaattga
      661 ctttgatgtc cgagtctttg cgtaatgatg gtcgtatctg ggttccgaag aaactggaag
      721 acgctaaggc tttacaggca ggaacaaaga aaggtaaaga tatacctgag gcagatcgcg
      781 attattattt ggagcgtcgt tatccggcat tcggaaactt ggttcctcgc gacgtggctt
      841 ctcgtgccgc taaagagcgt tgcgacgctg gcttcggtgt taataacaca ggtttggctg
      901 tattcttgga cttctccgac gctatcaacc gtctgggtaa agaggttgta aaacagaaat
      961 atggtaactt gttcgatatg tacgaagaaa tcaccaacga cgatccatac gaaactccga
     1021 tgatgatcta cccggcattg cactattcaa tgggtggtct gtgggttgat tatgaattga
     1081 tgacttctat cccgggtctg ttcgctatcg gtgaggcaaa cttctccgat cacggcgcaa
     1141 accgtttggg tgcttccgca ttgatgcaag gtttggccga tggttacttc gtattacctt
     1201 atacaatcca gaactacttg tcagaccaga ttcaggttcc gcgtttcagc accgatctgc
     1261 ctgagttcaa cgaggcagag aagaatatcc aagcccgtat caataaattg atgagtatca
     1321 agggcaaaga gtctgttgat tctatccaca aacgtttggg acacatcatg tgggaacaca
     1381 tcggtatggc tcgtaacgca gagagcttga aagaggctat ccagatgttg aaagacttga
     1441 agaaggaatt ctggagcaac gtattcattc cgggtaacgc agatgacttg aacgtagagt
     1501 tggagaaagc attacgtttg gcagacttta tcgagatcgg taccttgatg gcacatgacg
     1561 ctttagaccg tgctgaatct tgtggtggtc acttccgtga ggagcaccag actgaggaag
     1621 gcgaggcatt acgtcacgat gacaaattca tgtatgtctc ttgttgggaa tatcagggtg
     1681 aggataaaga ccctgttatg ctgaaggaag atttgaacta tgaattcgta gttcctcaga
     1741 cacgtaacta taagaagtaa tcaatcattg caaaaattag aatcatggat aaagatataa
     1801 atatcacact caaagtttgg cgtcagaaag gtccgaatgt aaaaggacaa ttcgaaactt
     1861 accaacttaa aaacatcaac caaggcactt ctttcttgga aatgttggat atcctgaacg
     1921 agcaattaat cagcgaaggt aaagaacctg ttgtttttga ccatgactgt cgtgaaggta
     1981 tctgcggtat gtgttcattg tatgtaaacg gacatccgca tggaccggca actggagcta
     2041 cgacttgcca gttatacatg cgccgtttca acgatggtga gaccatcacg atcgaaccgt
     2101 ggcgttccgc cggtttcccg gtaatccgcg acttgatggt agaccgttac gcttacgata
     2161 aaatcattca ggctggtggt ttcacatccg taaataccgg tggtgtaccc gacgcaaacg
     2221 caattcctat tcctaagcca gacgcagaga tggcaatgga tgccgctgct tgtatcggtt
     2281 gtggcgcttg tgccgccgct tgtaagaacg gttcagctat gttgttcgta tccgctaagg
     2341 ttagccagtt ggctttatta cctcaaggta aggtagaggc tgcccgccgt gcgaaagcaa
     2401 tggtcgctaa aatggatgaa cttggcttcg gtaactgtac gaacacacgc gcttgcgaga
     2461 tggagtgtcc gaagaacatc tccgttagta acatcgctcg tttgaaccgt gagttcattt
     2521 gcgctaagct acaagactaa tatttgatta gtatatcatg gaaaaggcgt ctttctctaa
     2581 aagaaaggcg cctttttatt tttgttatat gttgaaaaac ataatttagc actacagatc
     2641 ttgacaggaa ttgaaaagtc cgtatatttg catcgtggtt ttttcataat agtattagat
     2701 ttaaggttaa caaagtttgg ttagggcttg tcgtgagaca ggctttaatt gtttatagac
     2761 ctacctttta aacatggacc acaaaatact gcaaatagag attgtttagc gtcattttat
     2821 cgtcgatctt tgcctttaaa gatcatatag tatatgctaa taagtatttt atttggcttc
     2881 ttatgttatt ttctccgggt gttgatcaaa cacaaggaaa aaatcatgcg ccagataaga
     2941 caaatggtaa aacaaaaata aaatggacaa aaaacgaacc accagttctt tcagggcaat
     3001 gagcacggaa agaaaactcg agtcgatctt ccttttcgta acaggccgat gcaacgccaa
     3061 atgcgcgatg tgcttctatg cccaagaaat ggataagaag caacccgacc tcactttcga
     3121 tgaaatcaag aaaatatcag aaaccgctgg gcaattcaac cgattatgga tatccggggg
     3181 tgagcctacc ctgcgtgagg atctaccgga aatattggag ttattctaca aaaacaacca
     3241 tatcaaagat gtgaacatcc ctacgaacgg cttaaaacca gaccggatcg tcgaatgggt
     3301 aaaacggttc cgccagaact gcccggattg taatattaac gtaagccttt ccttggatgg
     3361 tttcggtacg acccacgata cacagagagg cgtaccggga aacttctata aggcactgga
     3421 aaccctgcgt aagatacagg agaatttcgg agacgacggc aaggtcctga aaaatatagc
     3481 aaccgttatc acgaaataca atatagacca ggtagaagac ttcatgactt gggtatacgg
     3541 acgtttccgt acctccacac atacgattga ggccgccaga ggcatgaccc gtgacgatgg
     3601 cgtgaaaatc ctaaccgagt caacgctacg caaaatacaa gatgacatat cccctatcta
     3661 ttcagcttat gcggatcgga tggtagcgga taccaccggc ttaaggaaac cgatcacacg
     3721 cttcttctat ctcggcctta tacgtacctt atataatata cgtgccagca acatagatca
     3781 cccgacccct tgggggatgg attgtacggc cggagagact accttggtaa tcgactacga
     3841 cggacgtttt cgtgcctgtg agttacggga accgctcgga aatataaaag agtatggttg
     3901 cgatataagt aaagtgatga atagcgaagc gatgaaacag gaaatagccg ctatcggaca
     3961 tgggtataaa gccaactgtt ggtgtacgca cggctgctgg atcacctcat ccgtcatttt
     4021 caatccacgt aagatgattc gctccgtata taaaggatac cgggaaacga aacgattgaa
     4081 tcatccctta gccatcaatg agcagaaact acaaacgatg gaagccaaat accatctgga
     4141 catcgagcgt ttgcgtcaac tgaatatccg gtaaacaaga ccctcatagc ccataaataa
     4201 acgtagcatg aaaatactat tagtaaccag aggctcacaa ggcgacgtcc ttccttattt
     4261 ggccatagcg gccgaattgg gaagacgcgg tcatgaggtg accatcaatc tccctcaaat
     4321 attcgaggag accgttaaac cctacggatt taaatacgta ttgcaacagt ttgacgatat
     4381 cggcggtatg atcgatagcg cagcgcaaaa ctcacataaa ttccggccat tccttaaatg
     4441 gatgcggaac gtgatcgata aacagttcga tcaattgatt cccctactaa aagagcatga
     4501 tattttagta tcgaccaact cggaatttgc tgtcgcaagt atcgccgagt attgcaagaa
     4561 acccttgata cgtaccgcct acgccccgtt cttgccgggt aagaagattc ccccggccgt
     4621 attgccattt cccaaaccca acccgatcat cactcccgct atcctatgga agttgatgaa
     4681 ccggatgacc aatttcatgg tcaaagacac gatcaataag aaccgggcta aatacggact
     4741 cgcgccgatt cgcaattttg gctatcacgc gggagagcgt tcatataatt acttgctttt
     4801 cagccagcac ctaggaaacg tagatccgga ctggacgttc gaatggtcga tcggaggcta
     4861 ttgcttcaat gacacttttc aatatgatga gaaggcttac gaggaaatga tatcattcgt
     4921 cgacagcgct caaagcccta ttatcttttt taccctcggg agttgtagtt ccaaggatgg
     4981 taaccgtttc agcaaagcct tggtcgatat ttgcaagaaa catgattatc ggctcatcat
     5041 cggttccggt tgggcaaaga caggaatcac cttacaagcg gataaacatt tattcttaat
     5101 gaagcagccg gttccgcata atttgatatt cccgcactgc gacggcgtta tccatcatgg
     5161 aggttgcggc acgacccata gcgtaggaag ggcgggaaag ccccaattaa tcactccgtt
     5221 gattatcgat caaccctatt ggtcctatcg aatccaccaa ttagggttag ggccggaagg
     5281 agttaagata gcgaaagcga gcgagcagga gatcgaacgc aaggtttgtg atctggtcac
     5341 caatccgctt tataagaaaa atgccgctca tataggcgag atgatccaaa aagagggagg
     5401 tataaagaat atatgcgact ctatcgaaag atttcaatga ggcataagtt cctattagat
     5461 tttattacat gttacaaaac acaatttagc acttaatcta ttgacaaata gcggtaactc
     5521 cgtatatttg catcgtggtt ttttcataat agtattagat ttaaggttaa caaagtttgg
     5581 ttagggcttg tcgtgagaca ggctttaatt gttttatgag gtctgcttcc cgcaaagccc
     5641 ttcgattaca tcagaataat ccgatgcgtc aataaagtcg atatcttgtc ctttaagacc
     5701 ttcccattaa tcggtttcgc cgtataggca tcaaatccac ttttaataat ccgctgctca
     5761 tcttgggcga aagcgtaagc cgtcaccgca attataggta cgttggaaga aaccttacga
     5821 atctctgcgg tagcctcata tccatccatg accggcatct ttatatccat caagatcaat
     5881 tgcggtttgt gccggtgaaa tagctccaca gcctcctttc cattccatgc atgaattaat
     5941 ttatattcag gtttcaatat agactcaaac aggcggtaat tactggaatt atcctcagcg
     6001 atcaagatcg taagctcatt acgggcgatc ttgtccaaag taacaggctt cggctcttca
     6061 ctaggcaata attctttctt cggctgaaaa ggcaatgtaa accagaacct agagcctttc
     6121 ccttccacgg aatcaacccc tatcattcct ttcatctggg taacaatcat ctcacagatg
     6181 cttaaaccca atcctgttcc ttgagcgaaa gtattcagtt tcacaaaacg tccgaaaata
     6241 tctttccgtt tattctccgg gattccgcag cccgtatcct ctacatagaa ccacaacgta
     6301 ttatcatcct tcaacttata gccaaataaa atcgatcctg cctgcgtaaa tttcatggca
     6361 ttgttcaaca gattgatcat cagttgagac agacgatttc gatccgtata aatcacgcaa
     6421 ggctccagat aatccttaaa tgagatctgt acatccggat tcttattctt caaatgagcc
     6481 gattgctcca aatccctcaa tacagcgtta atatccacat agtcataagt aaactccaag
     6541 gtacccgcct cgatctttga taaatccaag atatcgttta tcaactgcaa caatagggaa
     6601 ttattattct cgataatatc agcgaattcc ttcttatcct caaggtcatc ggtcgaggca
     6661 aggatattag agaaacctac gatcgcattt aacggtgtac gtatctcatg gctcatattt
     6721 gctaaaaacg ctgatttcaa tttattcgac tcctccgcct tatccctagc cattcgaagg
     6781 tcatgttcca attgcttacg ctcggtaata gatatcgtag acccgatcaa cgctttcggt
     6841 ttaccggaag catcatattc ggccattacc tgtatctcct cccactcatg gcgatcttct
     6901 cccggaatca accgctccag acaatattct tttcgtactt tctttatttt cccattacac
     6961 aaatcatcga aagccttttc cacgcaagcc ctgaaagacg ggtgtatctt gctgaaatat
     7021 tcctccaacg aaacctcatg ggtatgtatc tcggcagtct ctatattatc ttccggatgt
     7081 actttcgact catagataat cttcccttca gccagattat atcgccacgg caaaagatct
     7141 gccgcctcta gcgccatggc cagcttatga ttcatggctt tcaaatgcgt ctggaattta
     7201 tggatatccg taatatcaat aaaaaacgcg tcaactacat tctcttccga ggtaggcatg
     7261 atgataatcg tatagtaaag ccctgtcggc tcaaaataat actcataagt gaaggatttt
     7321 ccactctcta aaaccgtagg cactgccgat aggagcaaag gataactccc gccaatcaaa
     7381 tttgcgatct cttttccacg cttatttacc acaaaatctt taggagcgat tttctcctcg
     7441 aaagcatggt tcacatctaa aacctgcaca tcgatttgcg taccttcccg aatcagccgc
     7501 tgccgtatat aaggtaacgg catattatta aataaatcac ggtaacggga caacaacctc
     7561 aactctactt ccttcatctt ttgtttagaa cgatacacat aatgccccgc taaaaacact
     7621 actaccagaa agaatatcag aaagcctaac agctgcatcc aatatttttc caagaaagag
     7681 ggaggcgcat tcaaatagat cgcatcacgc gggaaattat cttcattaga tatcgcactt
     7741 atcaacgaag cataattcaa gtatttatga ggatcattta ccgtcgaaac cgggatcttg
     7801 cccatatctt caccgttata aacttgttgt agcaagggga ttagagcagt ctcaatcgtt
     7861 ttagcactat tataatatcc accaatcgta tatccttctt ccacgcccat atcatataaa
     7921 gaaaaaacag gatgcctaga aatgccgttt ataccttgat acaaagtact atataataac
     7981 gagtgattca agaaaggctt ctcggtaatc cacgagtaat acatcacggc cgtcgctcga
     8041 tgtgggtctt tctccgacag aaccgccatt aaactatcca tggagcaaga accctccgta
     8101 taaaaatcca ctttcccctc agggaaagaa gtttccatat gtttctccat ctcatcccga
     8161 agccatgtgg aaacataacg tctgtcggat atgaaaatca gacgtctcaa acccgggatt
     8221 aattccttaa ccaagtcgat cgaaccttta acataataag ggataaccaa gcccgtagcg
     8281 ttatacccct taaccgcctc ttgtaaaggg atcaccctat cagaggaatg ccgctgatta
     8341 aaataacatt catcttctgc catttcaccc gtttccgaac agaccagagt gggaatatcc
     8401 ccccatttct cccggatctt atcccgcata aaagcccatc catttacgcc taagtagata
     8461 attccatccg gcttcttctt attaacttca aagaaggcct cttgcttctc ttttaatttc
     8521 tctggcgtat caaccaacat cacgctcata tgatctatcc ggagggtgta ctcctccggg
     8581 gtagcgaact tcgagatcat gtttaataaa ttaccagacc agcgttcgcc atccacatat
     8641 gaatttatta ccaatacata cgattcatcc ttgaccggat atgaaaaact cccataagcc
     8701 ggagtcggca taccggctat caagcataaa atcaatccaa aataaagtat tattgccttt
     8761 aaatttataa tatttcgtat cattccctac attcctctat tgcagttgta aagacaaaga
     8821 tattccttaa ttatcaacta atcttatcaa actagttttt ttatcaagtt ttggtgtcaa
     8881 attcacgttt cttacaaact aaaggctttt ttaatcggga ttattcggtt atttaccgat
     8941 actcgtatag aaatcagcgg tatttacttg tgtatagaat gacgaacccg tacatttgat
     9001 aaaaaacaaa aaatggaact tatggatatg aaagattatg acatcgattt taaagagaag
     9061 aggacaaacg ggtatctgat cgctacctta tttatcattg tcggtatatt atttttactg
     9121 cggaatctag gaatgataga tccatcctta tttgacttgc ttgtatcttg gccgatgctg
     9181 cttgtcgtgt cgggcatctt tacgattttc caccgtaatc cggtaggagg tatgctcctc
     9241 gtgggcgtgg gagtctattt ccttttcccg cagttaaatt ggatcacgaa cgatttctta
     9301 cgtgtatatt ggccgttagg attaatcctg ttaggattgg tcatcatgct gaagcggaaa
     9361 gattctatcc gcacgaaaaa gcataaacgt ccttttaacc atcccccttt cgggcaccga
     9421 aagcctaacg atgagatcaa ctacgagaca gataacggtt tcgtatcggt tgacaccact
     9481 ttcaactcgg taaggcacat cgtactggac cccgtattca agggggcgga catagacgta
     9541 tctttcggca acgtgatcct cgatcttaaa aaaacaacat tagaggctga tgaaaccatc
     9601 ataaacatag atagctcctt cagcggcgta gtaatatatg tccctaaagg atggctggtt
     9661 cgtctaaagg ttgattcctt cttggctgga tgccaagata tgagggacct gacagaaaca
     9721 accgacatga cgcacacgtt gtatatatgt ggagacttgt cgttcagcgg ccttgaacta
     9781 agagactaaa ctcatcatgc aagaacatcc tattacaaca tccatattac ataaagggca
     9841 gggaagccta ttattacttt tagccatagc gatccaatgc gcattattaa ctctttatgg
     9901 cgatcttccg ttgagcatca ctttggtcga tagcttactt tccatcgcat tgttcgccgt
     9961 agcgggatat tatctttggt atgtacaatg tacgttacat atcatgcaag cacgagtggc
    10021 tttcgccgta ctcgtacaaa tcgcttgcat agccggatgc tcgatcttgc tacaaatatt
    10081 cggattggaa gattgggagg aattctcgat cacgattcct tttcgattcc tgttcggcct
    10141 aatggcatgg atcattctat cccaatggta tgccagccgg gaaagaaaga gtgaggcgga
    10201 acctatcgtg agacaaatgg aggaaaagac ggcacctccc ccgactactg ttccggagga
    10261 gattctagat cgtatatccg taaaagacgg gacacgtatt catatcatcc cgataaaaga
    10321 gatattctat ttacaagcat gtggcgacta tgtgacctta ttcactactt ccggtcagca
    10381 cgtaaaggag caaaccatga agtatttcga gcgaagcctt ccttctccgg agttcgttcg
    10441 tatacatcgc tcttatatcg ttaatacgga acagatattg cgagtagaac tattcggaaa
    10501 agaaacctat caagtacgat taaaggatgg aacctatctt cgtgccagta gcgctggcta
    10561 taagctactc aaagaacgtc tttcccttta gcagtcctat aaaagggacc taatcatcgt
    10621 taaaattaga agattttgat tgtaatatat agagttttat gttgtgtaac actttttggc
    10681 aagcatcgat atgttactta acatatatta gttgcaaaag acttgacaaa tggtcttgac
    10741 gaacgtatct ttgcatcgtg gttttttcat aatagtatta gatttaaggt taacaaagtt
    10801 tggttagggc ttgtcgtgag acaggcttta attgtttata gggatttgtt tccctagatt
    10861 tacatataac tataaaaaaa cggccacccc taaaaagagg cggccgtaat tataccataa
    10921 gataggattt ctattcctca acaataccta cgacttccat ttcaaaaatc atcgtagtgc
    10981 aaggttttac aacaacagcc ccggtattag gattcttata tcccgcttct ccatatccaa
    11041 gttgcgaggg aacccaaatc tcccatttat caccgggatg catattctgt aaagccgtgg
    11101 caaagccatc agtcatcttg tacacttcca tcaccgcagg ctctccagcc tcgaaagaac
    11161 gatcatcaaa aacttcacca tttataaaag agcctttata ataacattcc accttgctcg
    11221 tataataaat cggctcctta ctctccccag tcttcaagac cttgtaaagg ataaatccgg
    11281 cattactttg agaactcaat tgctcgaaac ccggaaccag catctgggct tgaaaagcct
    11341 cctcattctg gaccttccaa acctcatcca cctctagtgc ctcatcatca tccccacaag
    11401 aagtgatcat gagcacgcaa aacaacatca acgcaatatg ccagtacttc ttcattcgtt
    11461 tactctatta cctttttcaa taaattcttc atgctcacct tctccgtgat aatatcgtga
    11521 agcttatcga tgcttatgcg ctcttgctcc atcgtgtcac ggaaacggat cg
//
