LOCUS       c00038_gnlPro..        12253 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|JIAGLHKC_38.
ACCESSION   c00038_gnlPro..
VERSION     c00038_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 09:05:28
            Original ID  :: gnl|Prokka|JIAGLHKC_38
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12253
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12253
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[34:4743]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      35..4743
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..12253
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12253
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(35..1195)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_1"
                     /sec_met_domain="OAD_beta (E-value: 3.9e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(1197..1631)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_2"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.4e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             complement(1655..2587)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_3"
                     /sec_met_domain="OAD_gamma (E-value: 8.4e-18, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(2619..4172)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_4"
                     /sec_met_domain="CT_Btheta (E-value: 1e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(4231..4743)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg38_5"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.2e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             4937..6424
                     /locus_tag="ctg38_6"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             6568..7929
                     /locus_tag="ctg38_7"
                     /transl_table=11
                     /translation="MILIIDDDSAVRSSLSFMLKRAGYEVKTAPGPREAMDIVRAEAPA
                     LILMDMNFTLSTTGEEGLTLLKQVKVFRPDVPVILMTAWGSIQLAVQGMQAGAFDFITK
                     PWNNAALLQRIETALELTAAPKEVPEEQTTALNRSYIIGKSKGLMEVLNTVARIARTNA
                     SVLITGESGTGKELIAEAIHINSQRVKQPFVKVNLGGISQSLFESEMFGHKKGAFTDAS
                     ADRIGRFEMANKGTIFLDEIGDLDPSCQVKLLRVLQDQTFEVLGDSRPRKVDVRVVSAT
                     NADLRKMVSERTFREDLFYRINLITVKLPSLRERREDIPLLARHFADRQAEVNGLPRTD
                     FSADALNFLSRLPYPGNIRELKNLVERTILVSGKPVLDATDFDAQYLRHDEPAKVAEGT
                     SFAGMTLDEIERQTILQALEQHKGNLSQVAVSLGISRAALYRRLEKYNIQVPCA"
     CDS             7920..9233
                     /locus_tag="ctg38_8"
                     /transl_table=11
                     /translation="VRIKFFFFILVLFLLGLGGMLVYLLSGKPLLYLYVLEGLIGFILI
                     YLIVFYNKIVKPMNTIGSGMELLREQDFSSRLSRVGQYEADRIVNIFNRMMEQLKNERL
                     RMREQNHFLDLLIQASPMGVIILTMDDEVSQLNPMAVKMLGVRMEEAMAKRLDQMDSPL
                     AAELSSIPKDETAVVRLNDANIYKCTHSSFIDRGFKHPFFLIERMTEEVMRAEKRAYEK
                     VIRMIAHEVNNTTAGITSTLDTVEQALSTEDDMEDICDVMRVCTERCFSMSRFITRFAD
                     VVKIPEPTLVPVQLNELVSMCKRFMEGMCNDRNIELRLECDPEVGMVRMDASLFEQVLV
                     NIIKNAAESIEGDAGENGQQGEIIVRTTAPASVEVVDNGPGISKETEAKLFSPFFSTKP
                     NGQGIGLVFIREVLSRHGCTFSLRTYNDGLTRFRILFN"
     CDS             complement(9267..10901)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg38_9"
                     /sec_met_domain="Aminotran_1_2 (E-value: 9.8e-23, bitscore:
                     70.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 0.00011, bitscore:
                     10.9, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTKLLEKKMESISPFELKNRLIDMADESLKKTARTMLNAGRGNP
                     NWIATAPREAFFLLGSFGLEECRRIMDLPEGIAGIPEKKGIASHFEAFLKKNNNVSGAK
                     LLEQTYNYLLMQHAADPDSLVHEWAESIVGDQYPVPDRILHFTEILVQDYLSQEMCDNR
                     PPRGAYDLFATEGGTAAMCYIFDSLQENFLLNKGDGIVLMVPAFTPYIEIPQLSRYQFR
                     VTKIHANRMNSEGMHLWQYSDEDIDRLKSPKIKALFVTNPSNPPSYTLSPDTMARIVSI
                     VRNDNPNLMIITDDVYGTFSPHFRSFMAEIPYNTLCVYSFSKYFGATGWRNAVIALHEF
                     NLFDKLIAKLPKEKREILHHRYSTLTLEPERLKFIDRMVADSRQVALNHTAGLSLPQQM
                     QMGLFAAFALLDKENKYKQKMQEIIHRRLHALWENTGFTLTEDPLRVGYYTEIDMLVWA
                     KKFYGDDFVEYLKRTYSPLNVVFRLAKETSLVLLNGGGFDGPEWSVRASLANLDEKDYA
                     TIGRGIKKILEEYAKEFFKNGKAKGKN"
     CDS             complement(11178..12251)
                     /locus_tag="ctg38_10"
                     /transl_table=11
                     /translation="DEPGFMPAARPVTFRAYRVENEWFKNGKRVIDLEVYFRQHDKRLF
                     VERLRKSGVVVEVSMNIQIEPGDEVVLSGRREYIIGEESWIGPEVQDAQLLDFPAEKLP
                     VTITRKTVAGKTVAVIRREKFMHGVSIRSIKRAGISIPVLAQTVVDAGDVIEVVGTRQE
                     VEAAAKRLGYIDRPTNQTDMIFVGLGILVGGLFGALSVHIGGIPISLSTSGGALIAGLF
                     FGWLRSKHPTFGRIPEPSQWVLNNVGLNMFIAVVGISAGPSFVQGFHDVGISLFLVGAA
                     ATALPLIIGLLLARYVFKFHPALALGVCAGARTTTAALGAVQDAVESETPALGYTVTYA
                     VGNTLLIIWGVVIVLLL"
ORIGIN
        1 gaattcaagc cggataacgg aatgaataaa tgtattacat taagaatccc agcaggatac
       61 ctgctgctac agcggaaccg attacaccgg caacgttcgg gcccatagca tgcatcagca
      121 gatagttggt aggatcgtat tccagaccta ctacttggga gatacgtgca gagtcgggta
      181 cggcagatac accggcatta ccgatcaacg gattaatctt gttgcctttc ttcaggaaga
      241 ggttgaaaat cttcacgaag atgacaccgg atgctgtggc aatgacaaat gataaggcgc
      301 ccagaccgaa tatcttgatt gaatcaaggg ttaagaactc ggatgcttgc gtagaagcac
      361 ctactgtcaa accaagcaga atagtaatgg tatcaatcag cggaccactg gctgtgtttg
      421 ccagacgacg tgtaactcca ctttctttca gtaaattacc gaagaacagc atacccagca
      481 aaggcagacc ggatggtaca aggaatgtgg ttagtaacaa accgataatc gggaacatta
      541 ctttttccgt atgtgaaacc acacggggag gtttcatacg gataagacgt tcatttttac
      601 tggtcagcca acgcataata ggcggctgta tcaccggtac taatgccata tatgaatagg
      661 ctgataccgc aatggcaccc attaagttag gagccagttt ggaagagagg aagatggcag
      721 tcggaccatc ggcaccacca atgataccga ttgcaccagc ctgcatcggg tcaaatccta
      781 tggcaagggc aatcatataa gcaccgaata taccgaattg ggctgctgca ccaaccaaca
      841 ttaatttggg gttcgatatc aaagcggaga aatccgtcat ggcaccgata cccaggaata
      901 tgagtggcgg gtaccaaccg gaggttactc cctggtacag aatattaagt acggaacctt
      961 cttcatagat accgactttc aatccggctt ccatattgaa aggtatatta ccaatcagca
     1021 taccgaaacc gataggaatt aatagcatcg gctcaaattc cttggctaca gccaagtata
     1081 tgaaaaacaa acctaccaga agcattacca catgtcctac cgttgcattg gcaaaacctg
     1141 tataagtcca gaagtcggca aggttgtttc ctaaaaatgt gataaattct cccatattat
     1201 tcaataatta cgaggtcagt accttcgaga acagagtccc ctttgtttac attgatggct
     1261 gtaatcttac cgtctttatc agcattgata ttgttttcca tcttcatggc ttccagaatg
     1321 atgataactt gtcccttctt tactgtatcg ccgacattta ctttgatatc gaggattaca
     1381 ccgggaagcg gagattttac acctgacttg ccggtagaag cagcggccgg ttttactacc
     1441 ggagtagcag gagcagcagg agcggatgtg gctgccggac gtgctaccgg tttaacgact
     1501 accttcggtg ctttttccat ttcaactttg tagggagtac cgttcacttc tacgtgagcg
     1561 atgttgtctt caatatctcc aatggcaact ttatatacgt taccgttaat tttatattta
     1621 tattctttca tcgttttatt ttattatggg tgacttactt tttgtgagga gtctcacgca
     1681 acgtataaat ctttgaactc cacggtgagt aactgcgttt tacacgggta atggtaagta
     1741 tcgtgtcttc cacatcgtgt acatcgcttt ggaattcgtg catggccatt gaaatggcag
     1801 caaaaacttc tcccggagcc tgccccagtt gtttctcttt tgcttcttgt ttatcagtaa
     1861 tacctttagc tttcatggca ttgcgtttgc tgaggttaac tgatatttta cctataatct
     1921 tgaaggagat gtagagtaat atcagcccgc agaatacaac gctcatggca gaaatagcca
     1981 taccgatacc tacgctgtca tgctcttcga atttttccat tttggcattg ctgtcgatag
     2041 tcttgttgtt ggtactcgga gtgacatatt tatcttcgct tccacccttt acttcccatt
     2101 ggtcggctgc atcactgaca cgggcatagg attggttggc ttttaaagta ccggcaggca
     2161 ctatgacttg atcaagcaat ttcttgccgg aatcatacaa cccaatccag ttggcatttg
     2221 tggcatccag tttgaagttc gtatgaaatg taccgcgtct tggttctcca tcagcccaga
     2281 aaagtgcatg ctgacgtggt tttatgagtg tcagaacgtc acctttggga atgaaataac
     2341 tggcagtatc acccggctgg ctgctgaatt tcagatagca acctgcaagg tcggcgctgc
     2401 cgtatgatct gttgaatatt tcaatccatg cgctgtgcac accgtagtca tcctgatagt
     2461 tgctttcgtt gttgaccagc acttcattca gcagcagttt gttgttcgat ttctgttctt
     2521 tgcaagaaga gcaaaagccc aacaccagca tcaatgaaag gaatattccg atttttgttt
     2581 tattcataat cgttcttgtt ttagtgtgaa aagcttgatt acaagggaat attaccatgc
     2641 ttcttagccg ggttagtcaa tttcttggtt tgcaactgtt gcagggcacg aatgatgcgg
     2701 aaacgtgtgt tacgcggttc gataacatca tcaatgtagc catatttagc tgcattataa
     2761 ggattggcaa acaacttggt gtattcagcc tctttttcag ccaggaattg agccggattt
     2821 tcctgctctt tggcttcgcg ggcatataat acttctacag cacctgcacc acccattaca
     2881 gcgatttcag cagtaggcca agcataattc atgtcgccac gcagctgctt acagctcatc
     2941 acgatgtgcg aaccaccgta ggatttacgc agtgtgatgg taaccttggg tacagtagct
     3001 tcaccgtatg catacagcag tttggcaccg tgcaggatga cgccgttgta ctcctggccg
     3061 gttcccggaa ggaatcccgg tacgtctacc aatgatacga taggaatatt gaaggcgtcg
     3121 cagaaacgga cgaagcgtgc gcccttgcgg gatgcgttgc tgtcgagcac acctgccaga
     3181 tacttcggct ggttggcaac aatacctacg gactgtccgt tgaaacgtgc gaaaccaata
     3241 atgatattct ttgaataatc tttttggatt tcgaggaact caccattatc tatgatagcg
     3301 ccaattacct cgtacatatc gtacggtttg ttcgggttat caggaatgat atcgttcagg
     3361 gaatcttcca gacggtcaat agggtctgta cagtctacat agggagcttc ttccagattg
     3421 ttctggggaa tgtagctcaa cagtttgcgg ataagggcca aaccttcttc ttctgtctgt
     3481 gcagtaaaat gagtaacacc agatttggtg gagtgaacgc tcgcgccacc caggttttcc
     3541 tggcttacgt cttctccggt tacagtcttt actaccttcg gaccggtaag gaacatgtag
     3601 gatgtacctt ccatcatcaa agtaaagtct gtcaaggcag gagagtaaac ggcgccaccg
     3661 gcacaaggac cgaaaatacc ggaaatctgc ggaatgacac ccgaagcaag tatgttacgt
     3721 tggaagattt cagcgtagcc tgccaaggca ttaatacctt cctgaatacg tgcaccgccc
     3781 gagtcgttga taccgataca cggagcaccc attttcatgg cttggtccat aatcttacag
     3841 attttcagag acatggtttc ggacagtgaa ccggcagaaa ctgtgaagtc ctgtgcgaag
     3901 atataaacca gacggccttc gattgtaccg caaccggtta ctacaccgtc accggggtag
     3961 tgtttctttt ccatgccgaa gttggtgcat ctatgttcta cgaacatgtc catttcttcg
     4021 aaactgcctt cgtcgagaag catggctatg cgctcgcgag ctgtatattt acccttctcg
     4081 tgttgctttg caatcgcttt ttcaccacca ccgagacgtg ctgcagcgcg gcggtctata
     4141 agctctttaa tcttttcaag ttgattactc atgaatttat attctttaag tgtttataca
     4201 atttatgatt tgatgatttt acagtcttgc ttattccggt ttctcgcaaa gctcggtcag
     4261 gacaccgaga gttgacttcg gatgcaggaa tgcaatgttc agaccttctg cacctttgcg
     4321 gggagctttg tctataaggc ggataccttt ttcttcgact tcggcaagcg caccggccac
     4381 tccgtcttca acggcgaatg cgagatgatg catgccaccg ttaccgttgt tcttttcgat
     4441 gaacttggca attgtgcttt cgggagaagt aggttccaac aattcgatct ttacatcgcc
     4501 cactttcagg aaagcggttc taactttctg atcttccacg gtttcgatgt tgtagcattt
     4561 caaacctaaa acgttttcgt agtacggaag ggcttcttca atgctcttaa cggcaatgcc
     4621 cagatgctca atgtgtgaaa tcttcataac tatataaatt aatgttagta ttgtatcctt
     4681 tttaataaag gtataaagca gcacaaagaa agagaattct tccttaataa agaaattttt
     4741 catcaattaa ttaatggtta attgaacttt agaaggattt tttcagactt tagatagaga
     4801 ccggttgttt tcttgatatc gtccgctaac ggacatcccc actgtccgaa aatgaacact
     4861 tacccctcta tgaaaccttt ccggccactt ggcacactct ttgcttttct gtttgcgaca
     4921 attttaaaga ttgaacatga aaaagaatat tttacttgca gtttgttttt tgatgccgtt
     4981 ggcaaccatg gcgcagaatg atactttggg acatgaacgc aatattacgc tgtcggaggc
     5041 cattgtactg gcccgtacgc agtctgtgga tgctgctgtg gcattgaatg aattgaaaac
     5101 cgcgtattgg gaataccgta cattccgtgc ggacttgttg ccggaagtga atttcaccgg
     5161 tacactaccc aactataaca agtcctacag tacctaccag aattccgacg gctcctatag
     5221 ctttgttcgc aacaatacac tggggctgtc cggacagctt tcggtagacc agaacatttg
     5281 gtttacgggg ggtaagctgt cactgacttc ttcgctggat tatctcaaac aactgggttc
     5341 cggaggagcg aagcagttca tgtcagtccc cgtgagtctg gagttgacgc aaccggtctt
     5401 cggagtgaat accttgaagt ggaaccgccg tatagagccc gtacgctatg ccgaggcaaa
     5461 ggccgagttc atttcagcta cggaagaggt gacgatgaaa accatcactt atttctttga
     5521 gttgctgctg gccaaagaat cgctcgctac cgccatgcag aacaagacga atgccgaccg
     5581 cctttatgaa gtggccatag ccaaacgtaa aatgggacag atatccgaga atgatttgtt
     5641 gcagcttaaa ctgaattcat tgcagggcaa ggccgacgtg actgaggcag agagcaacct
     5701 gaatgcaaaa atgttccagc tccgttcttt cctcggggtg tccgagcagg aaagcctgaa
     5761 tccggtgttg cccgccactg ttcccgatat aaagatggag tatgaccgtg tgctgaacaa
     5821 ggcactggaa cgcaactcct ttgcacagaa cattcgccgc cgccagctcg aagctgatta
     5881 tgaagtggca acggcacgcg gaaacttgcg cagcatcgac ctctttgcca gtgtgggcta
     5941 tacggggcag aaccatgaat tctcttcagc ctaccgggac ttgcttgaca atcagattgt
     6001 gcaggtaggc gtcaagattc ctatccttga ctggggcaag cgccgcggca aggtaagggt
     6061 ggcaaagagc aaccgtgaag tggtcttgtc cagaatccgt caggaacaga tggactttaa
     6121 ccaggacatc tttttgctgg tggctaactt caacaaccag gcgcaacagc tggacatagc
     6181 cgaagaggcg gatgtcattg ctgagaagcg ttacaagact agtgtagaga cctttatgat
     6241 aggtaaaatc agcaccctgg acctgaacga tgcacagaac tctaaagacg aagcccgtca
     6301 aaagcatatt tcagagctgt actactattg gtattacttc tatcagctcc gcagcttgac
     6361 cctttgggat tttgaacgcg atacggaatt ggaagctgat tttgaagagg tggtaagagg
     6421 ataagtcgac gggttgcaag tgataagtta tgaattattt gccggtaaaa gtaccgtata
     6481 tgcgatatta taggtaaata acttataact tatcattcat aactctgctt ttttacttat
     6541 ttttgcggga aacaaactac aatttttatg atactgataa tagacgacga tagtgctgtg
     6601 cgctcttccc tcagctttat gctgaagcgt gccggatatg aggtgaaaac ggctccgggt
     6661 cctcgcgaag ctatggatat agttagggcc gaagctcccg ctttgatttt gatggatatg
     6721 aacttcactc tttccactac cggagaagag ggacttacct tattgaagca ggtaaaggtg
     6781 ttccgtcccg atgtgcccgt tattttgatg acggcatggg gaagtatcca gcttgccgtg
     6841 cagggtatgc aggccggcgc attcgatttc ataactaagc cttggaacaa tgctgctctt
     6901 ttgcagcgca tcgagacggc ccttgagctt acggccgccc cgaaagaggt gccggaagaa
     6961 cagactaccg cattgaatcg cagctatatt ataggtaagt ccaaagggtt gatggaagtg
     7021 ttgaacacag tggcccgcat agcccgtacc aatgcttcgg tgctgattac gggcgaaagc
     7081 ggaacgggca aggagctgat tgccgaagcc atccatatca acagccaacg cgtgaagcag
     7141 ccctttgtca aggtgaacct tggtggcatc tcgcagagct tgttcgagag cgagatgttc
     7201 ggccataaga aaggagcgtt taccgacgcc agcgccgacc gtatagggcg ttttgaaatg
     7261 gcaaataaag gtactatctt cctcgacgag attggtgacc tcgacccttc ctgccaggtg
     7321 aaactgctgc gcgtgcttca agaccagaca ttcgaagtgc tgggcgatag ccgtccccgc
     7381 aaagtcgatg tacgcgttgt gtccgccact aatgcagacc tccgcaagat ggtgtccgaa
     7441 cgtactttcc gtgaagacct tttttaccgt atcaacctga ttaccgtaaa actgccctcc
     7501 ttgcgggagc gccgtgaaga tattcctttg ctggcacgtc actttgccga ccgtcaggca
     7561 gaggtgaacg gcttgccgcg tacggatttc tcggccgacg ctctgaattt cctttcccgc
     7621 ctgccttatc cgggcaacat tcgtgagttg aagaatctag tggagcgtac cattctggtc
     7681 agcggcaagc cggtgctgga tgccacggat ttcgatgccc aatatctgcg tcacgacgaa
     7741 ccggccaaag ttgccgaagg tacttctttt gcaggtatga ccttggatga aatagagcgg
     7801 cagactatct tgcaggcgtt ggaacagcat aaagggaatc tcagtcaggt ggcagtgtca
     7861 ttaggcatca gccgcgctgc gctttacaga cgtttggaaa aatataatat tcaagtcccg
     7921 tgcgcataaa attctttttc ttcatacttg tcctttttct gctcggtctg ggtggaatgt
     7981 tggtatattt gctgagtggg aagccgcttt tgtatctgta cgtattggag gggctcatcg
     8041 ggtttatcct tatctatctg atagtattct ataataagat agtgaagccg atgaacacca
     8101 taggcagcgg tatggagttg ctgcgcgagc aggatttcag tagtcgtctc agccgggtag
     8161 ggcagtacga agcagaccgc attgtgaata tctttaaccg aatgatggag cagctcaaga
     8221 atgaacggtt gcgcatgcgc gagcagaatc acttcttgga tttgctgatt caggcatctc
     8281 caatgggggt tattatcctg acaatggacg atgaagtgtc gcaactgaat ccgatggcgg
     8341 taaagatgct cggtgtccgt atggaggagg cgatggcaaa gcggctggac cagatggact
     8401 ccccgttggc tgccgaactt tcgtccattc ccaaagacga gacggcagtg gtccgtctca
     8461 atgacgcgaa tatttataaa tgcacccatt cttcttttat tgacagaggg ttcaaacatc
     8521 cttttttctt gatagagcgt atgacagaag aagtgatgcg tgccgagaag cgtgcctatg
     8581 aaaaggtaat ccgcatgata gctcatgaag tgaacaatac cactgcgggc atcacttcca
     8641 cactcgatac agtggagcag gcactttcta cagaagatga tatggaggac atctgcgacg
     8701 tgatgcgcgt ctgtacggag cgttgtttct cgatgagccg tttcattacc cgttttgcag
     8761 atgtggtaaa gatacctgaa cctaccctgg tgcccgtcca actgaatgag ttggtgtcca
     8821 tgtgcaagcg ttttatggaa ggaatgtgca atgaccgcaa tatagagcta cgtctggaat
     8881 gcgacccgga ggtgggaatg gtgcgtatgg atgcttctct ttttgagcag gtgcttgtga
     8941 atatcatcaa gaatgccgcc gaaagtatag agggggacgc cggagaaaac ggacagcaag
     9001 gtgagataat agtaaggacc actgcccccg cttctgtcga agtcgttgac aatggtccgg
     9061 ggataagtaa agagaccgaa gctaaactct tcagtccctt cttttccacc aagccgaacg
     9121 ggcagggaat tggcctggtg tttatccggg aagttttgag ccgtcatggt tgcacgttct
     9181 ccctacgtac ctacaacgat ggattgaccc gcttccgtat actatttaat tgaaatttga
     9241 aagttttacc tttcaccttt caattttcaa tttttacctt tcgcctttcc atttttaaag
     9301 aattcttttg catactcctc cagtatcttt ttaatgcctc ggccgatggt cgcatagtct
     9361 ttctcgtcca gattggcgag tgaggcgcgc acgctccatt cggggccgtc aaaaccaccg
     9421 ccgttcagca gcaccagaga ggtttctttg gcaaggcgga agactacgtt cagcgggctg
     9481 taggtgcgtt tcagatattc tacaaagtcg tccccataga acttctttgc ccaaaccagc
     9541 atgtcgattt ctgtataata acctacgcgc aacgggtctt ccgtcagcgt gaaaccggta
     9601 ttctcccaaa gggcatgcaa tcggcggtgg ataatctcct gcatcttttg cttgtatttg
     9661 ttttccttgt ccagcagggc aaaggcggcg aaaaggccca tctgcatctg ttgtggcaat
     9721 gacagtccgg cggtatggtt cagtgccacc tgacggctgt cggcaaccat acggtcgata
     9781 aacttcagtc tttcaggttc cagagtgagg gtggagtagc ggtggtgcag aatctcccgt
     9841 ttctctttcg gcagtttggc tatcagcttg tcgaacaggt tgaattcgtg cagggcaatg
     9901 accgcattgc gccatccggt ggcaccgaag tatttggaga atgaatagac gcaaagcgta
     9961 ttgtagggaa tttctgccat gaacgaacgg aagtgcggac tgaatgtacc gtatacgtcg
    10021 tctgtaataa tcatcagatt agggttgtca tttctgacga tgctcacgat gcgcgccatt
    10081 gtatccggac tgagtgtgta gctgggcgga ttactgggat tggtgacaaa gagggccttg
    10141 attttagggc ttttcaagcg gtctatgtct tcgtcgctgt actgccagag gtgcatccct
    10201 tcgctattca tgcggttggc atgtattttg gtcactcgaa actggtagcg gctgagttgt
    10261 gggatttcaa tatagggggt aaaggcagga accatgagga cgatgccgtc ccctttgttc
    10321 agcaggaagt tttcctgcag ggagtcgaag atgtagcaca tggcggctgt tccaccttcg
    10381 gtggcaaaca ggtcataggc accccgggga ggacggttgt cgcacatctc ttgcgaaagg
    10441 taatcttgca caaggatttc cgtaaaatga aggatgcggt cgggcacggg atactgatcg
    10501 cctacaatgc tttcggccca ttcgtgtaca aggctgtcgg ggtcggcggc atgctgcatc
    10561 agcaggtagt tgtaggtttg ttccagcaat ttggcgcccg atacgttatt gttctttttc
    10621 aggaaggctt cgaagtggga ggcaatgcct tttttttcgg ggatgcctgc aatgccctcg
    10681 ggcaaatcca tgatgcgacg gcactcttcc aagccgaagc ttcccaatag gaaaaaggct
    10741 tcgcgtggag cggttgcaat ccagttgggg ttgccgcgcc ctgcgttcag catggtacgg
    10801 gcggttttct tcagactctc gtctgccatg tctatcaggc ggttcttcag ttcgaaagga
    10861 ctgatagatt ccattttctt ttctaaaagt tttgtatcca taagctcaag tttaggttcg
    10921 ttatttattg ttttcagtca ttcggcgaat aatctctgtt catgcggtat actatttctt
    10981 tccttgcttg aaattaatcg tccgatatat gtttcctttt cgtccgacag ttgttgaatc
    11041 atcgtccgac aactgttgaa ttatcgtccg acagctgtcg gacgaatagc tattagtgaa
    11101 tgggtatata gtcgcttgca tttccggcaa taattctttg aatggttcgg attagtaagt
    11161 atcggcacag aatcgtctta tagtagcaaa acgatgacta caccccatat tattaataag
    11221 gtattgccca cggcataggt cacggtgtat cccagagcag gtgtctcgct ctcaacggca
    11281 tcctgcactg cgcctaaagc ggccgtagtg gtacgtgccc ccgcgcagac gcccaaagcc
    11341 agtgccggat ggaacttgaa aacatacctt gccagcagca agccgataat cagcggcagg
    11401 gcggtggcgg ctgctcccac cagaaacagg ctgataccta cgtcgtggaa gccctgcacg
    11461 aaactgggac ctgccgaaat gcccactacc gcaatgaaca tgttcagacc gacattgttc
    11521 aacacccatt gcgaaggttc gggaatgcgc ccgaaggtgg ggtgcttact gcggagccag
    11581 ccgaagaaca agcccgcaat caatgcgccg ccgcttgtgc tcaagctgat ggggatgccg
    11641 ccgatatgga cggaaagtgc tccgaacaaa cctccgacaa ggataccaag gcctacgaat
    11701 atcatatccg tctggttggt agggcggtct atatacccca gacgtttggc tgctgcttcc
    11761 acttcctgcc tggtacctac cacttcgatg acgtcgccgg catctactac cgtttgtgcc
    11821 agcacgggaa tggatattcc ggcgcgcttg atgctccgga tactgacacc gtgcatgaac
    11881 ttttcccttc ggataactgc aaccgtcttg ccggcaaccg tcttgcgtgt gattgtaacc
    11941 ggtaactttt cggcaggaaa atccaggagc tgggcatctt gtacttccgg ccctatccag
    12001 ctttcttcgc ctatgatgta ttcgcggcgt ccgcttagca ctacttcgtc tcccggctct
    12061 atctgtatgt tcatgctgac ttccaccaca actccggatt tgcggaggcg ttccacaaat
    12121 agacgtttgt cgtgctgccg gaagtagact tccaggtcaa tcacccgctt tccattcttg
    12181 aaccattcgt tttcgacccg gtaggcacgg aaagtgacgg ggcgtgccgc cggcatgaat
    12241 cccggttcgt cag
//
