LOCUS       c00012_gnlPro..        14417 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HLBLAOGO_12.
ACCESSION   c00012_gnlPro..
VERSION     c00012_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 09:05:54
            Original ID  :: gnl|Prokka|HLBLAOGO_12
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14417
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14417
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[927:4417]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      928..4417
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..14417
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14417
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(2..295)
                     /locus_tag="ctg12_1"
                     /transl_table=11
                     /translation="MEAAPEPDPLPFEAIRIHGERTVGPPSTSADGHSAHGTFTIPEGK
                     GGKKLYGTCSLFLGVDDWGSLEVKDSGGNVVAQVDLKENPQTAGEQGGHKYHT"
     CDS             complement(928..1695)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_2"
                     /sec_met_domain="Fer2_3 (E-value: 2.2e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 7.5e-11, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.3e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(1736..3694)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_3"
                     /sec_met_domain="FAD_binding_2 (E-value: 4.2e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.2e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(3716..4417)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg12_4"
                     /sec_met_domain="SucD_FumR (E-value: 2.6e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             4618..4890
                     /locus_tag="ctg12_5"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             4893..5708
                     /locus_tag="ctg12_6"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(5742..6149)
                     /locus_tag="ctg12_7"
                     /transl_table=11
                     /translation="MQSPASLSIRNSPSFQQSISPHGPDRCGSVRRQQTPSLKQGKGVG
                     KWLSLNLYPPFPSMNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPDE
                     FLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(6404..7111)
                     /locus_tag="ctg12_8"
                     /transl_table=11
                     /translation="MNKLLSTLILSAGMSLSATAATALLDSSIVGYSDFASQTADFGTR
                     KDSVSITSDDSNLTLSGITFNGYGANNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQINQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGL
                     LGLAALMMRRRRA"
     CDS             complement(7142..7231)
                     /locus_tag="ctg12_9"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKHKYIH"
     CDS             7406..8146
                     /locus_tag="ctg12_10"
                     /transl_table=11
                     /translation="MKKTLTFLIAMGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGL
                     GSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNT
                     GTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAP
                     TANTEGDTVTISGGLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRRRA"
     CDS             complement(8441..8689)
                     /locus_tag="ctg12_11"
                     /transl_table=11
                     /translation="MRVSPSFIPEQDAVAIHGSRIVGNIVDATSVIRADDGKEYEVLGM
                     GPIAVLPEYQRRGIGRRIIGMRRPSRSVRCKGDPYPA"
     CDS             complement(8823..10028)
                     /locus_tag="ctg12_12"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPAA
                     GASLRMIAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYAAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSAGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPTKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             complement(10052..10798)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg12_13"
                     /sec_met_domain="adh_short_C2 (E-value: 2.3e-75, bitscore:
                     245.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSCGG
                     AAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLRMK
                     EEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKAGL
                     IGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDIAA
                     LTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(10822..11442)
                     /locus_tag="ctg12_14"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPSAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAASKDILENSDEFSDLVEPDENGAPPMH
                     SGKMKRPDSSPPPRFSPLFFIPGTPFPRMGSCAAKSISSLPEP"
     CDS             complement(11506..12981)
                     /locus_tag="ctg12_15"
                     /transl_table=11
                     /translation="MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITP
                     EMEQAIHTIRTAENANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRP
                     AREMSGGWIMRAYLAKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHD
                     RDFMDELVESVYDIDNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFID
                     RFRSINSKAGQVQSRIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSY
                     GDRRVYENLDLLVERGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFS
                     QARTENLNPENTVLEEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLS
                     LVKFLVDPPNLLLMDEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLH
                     VNRGTITAYAGGYDYYLEKSGILDDEKGGITAE"
     CDS             13046..13192
                     /locus_tag="ctg12_16"
                     /transl_table=11
                     /translation="MVISVSLNKVRPAWDFVRFLIVSMVKRGCILPGWKGEGKSRQGGG
                     WHF"
     CDS             13239..13946
                     /locus_tag="ctg12_17"
                     /transl_table=11
                     /translation="MPTTQTFRLLLAAALLCGWSSCCTPPAEDYIQQTYVQQQMSGLAN
                     AFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNRTVLFGWLNNILVNSNLRDRG
                     LCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCVYVNAAGKGLQGSIVLDAWKN
                     CGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGMEHHLVWPGWARKRPILVQRIF
                     QSDQQNEAKAAAE"
ORIGIN
        1 ccgtgtggta tttgtgcccg ccctgttcgc ccgccgtctg cgggttttcc ttcagatcca
       61 cctgcgccac cacgttgccg ccggagtcct ttacttccag gcttccccag tcgtccaccc
      121 caaggaagag cgagcaggtg ccgtagagct tttttccccc cttcccttcc gggatggtga
      181 atgtcccgtg cgcgctgtgc ccgtccgccg acgtgctcgg cggccccacg gttctttccc
      241 catggatccg gatcgcttca aacggtagcg gatcgggctc cggagctgcc tccatgcccc
      301 gcctgccggg gctgccgccg gctccaaagt accatttccg gtaagcggga acggcagaac
      361 gatgaggcgg attcatcagg tattaaaaag ctgagattaa tgaataaaac aagatgaggg
      421 caatcctcag cgggcatttt cccaatagca ttattcagat ttagcgtcaa taagaattta
      481 tttgaaaaat ttctgttatt ttaagaacat gagaatttat tccatgagaa aataatatta
      541 taattcttac gctcagtgca ttcccttaat agacatcaat gttgtctgtt tgttagaaaa
      601 tgttttcctc tcatgctgag cccttgacag gaggctatcc cttccgggca tcagtctaat
      661 tcctgtaatc aatgtttttc tctctcgaag aaagatgggg ccgtcgctgt cggacggggg
      721 cttgcttagg tttcgtccgg catttccaag tacggtctcc tggattactg ggtgccttcc
      781 ggtgtaacaa ttttttacgc tgcgcgacga tgaggaagca actgtctggt attttattcc
      841 tggttcaagg aaatctggta atgaaaaaac tcccgacagc cgatgccgcc gggagttttt
      901 acagagcgtc ttaagaagga atcttcttta gaaacagagg ccttccttgg cgttggcccg
      961 catgaagtcg cggttgaggc gggcgatgtt gtccacgctg atgcctttcg ggcaggcggc
     1021 ttcacattca tactggttcg tgcagttgcc aaagccttcc gcttccatct gcttcatcat
     1081 ggccaggacg cgcttggaac gttccggctg gccctgcggc agcagattga gatgggcgat
     1141 cttggcggag gtgaacagca tggcggaagc gtttttacag gaggccacgc aggcgccgca
     1201 gccgatgcag gcggccgcgt caaaggcggc gtccgctttc actttttcca cggcgatgtt
     1261 gttggcgttc ggcgcggaac cggtacgcac gtcaatatag cctccggcgg cgatgatgcg
     1321 gtccagggcg gagcggtcca ccatcaggtc ccgcaggatt gggaaagcct tcgcgcggaa
     1381 gggttcaatc cagacggtat cgccgtcctt gaacttgcgc atgtgaagct ggcaagtggt
     1441 cacctggcgt tccggcccgt ggggaatgcc gttgatggtc agggagcaca tgccgcagat
     1501 gccttcccgg cagtcgtggt caaaatggat gggttccttg ccttccttga ccaggccttc
     1561 attgacgatg tccagcattt ccaggaagga ggcgtccacc ggaatgtcct tggcggcata
     1621 ggtctcaatg cggcccttgg cttcccggtt ttcctggcgc cagaccttga gagtgagatt
     1681 gagtgtttta gccatgttat aatctttctt ttgagtgtta atgtattggc tatctttact
     1741 tgtagctgcg gatggcaagg tgcacgttct cgaaggtcag cggttccttg tggagaacag
     1801 gcaggctgtc cacgccagtg tattcccagg cggctacata ggcgtattca tcgtcgttgc
     1861 gcttggcttc gccgtccggc agctggtatt ccacgcggaa gtgggcgccg caggattcct
     1921 ggcggttcag ggcgtcatag cagagcagct gggcgaattc caggaagtcg gccacgcggc
     1981 aggctttttc cagttccgcg ttgatgccgt ccgccgtgcc ggttacgcgc acgttttccc
     2041 agaattcctt gcggagctgg ggaatgcgtt caatggcgtg ggtcaggctt tcttccgtgc
     2101 gggccatgcc gcagtcttcc cacatgatga ggcccagttc ccggtggaag gagtccaccg
     2161 tcttggtgcc cttcacattc aggagcttgt tgatgcgttc cttcacttcg tcttccgcag
     2221 ccttgaattc cggggcggcg gtggtgacgg cgccgggctt ggtggtcgtc aggtaagcgg
     2281 gcaacgtggc gggaatgacg aagtagccgt cagacaggcc ctgcatcagg gcggaggctc
     2341 ccaggcggtt ggcgccgtgg tcggagaagt tggcttcacc gaggacgtgc agccccttca
     2401 cgttggacat gaggttgtag tccacccaca ggccgcccat ggtgtagtgg gaggcggggt
     2461 agatcatcat gggcgtttca tgggggtcgt cgtccgtgat ttcttcgtac atgtcaaaca
     2521 gattgccgta ttggccgtca atccattcgc ggcccatgcg cttgatttca tccgcaaaat
     2581 ccaggaagac gcccttgccg gtgacggcca cgccgcggcc gtcgtcgcag gcttccttgg
     2641 cggcgcggga ggaaatgtcg cgcggagcca ggttgccgaa ggagggatac ttgcgttcca
     2701 ggtagtagtc ccgttcttct tcgggaacat cggaaggctt gatttccttt ttacggattt
     2761 tttctgcggt ttcacgggac ttgggcaccc agatgcggcc actgttgcgg agggattccg
     2821 acatcagcgt cagtttggac tggtagtcgc ccttgaccgg aatgcaggtg gggtggattt
     2881 gcgtgaagca ggggttggcg aagaaggcac cgcgcttgta ggccttgtag gcggcagtga
     2941 cgttgcagcc catcgcgttg gtggacagga agaacacgtt gccgtagccg cccgtgcaga
     3001 gcaggacggt atcccctgcg taggatttga tttcgccggt aaccagattg cgggtgacga
     3061 tgcccttggc ttcgccgtcc accagcacca gatccatcat ttcatggcgg gagaacattt
     3121 caatgtgtcc cttggccact tccttttcca gggcctggta ggcacccagc aggagctgct
     3181 ggcccgtctg tccgcgtgcg tagaaggttc gcttgagctg ggcgccgccg aaggagcggt
     3241 tgtccagcag gccgccgtat tcacggccga agggaacgcc ctgggccaca cactggtcaa
     3301 taatgttgga ggagacttcc gccagacggt agacattggc ttcacgggcg cggaagtcgc
     3361 cgcctttaac ggtgtcgtaa aacaggcggt aaacggagtc gccgtcgttc tggtagttct
     3421 tggctgcgtt aatgccgccc tgggccgcaa tggagtgggc gcggcggggg ctgtcctggt
     3481 agcagaagca tttgacgttg tagccaagtt cggcaagcgt ggcggcagcg gaggcgccag
     3541 ccaggccgga acctaccaca agcaccgtgt acttgcgctt gttgttcgga ttgatcagtt
     3601 tggactcaag tttgtacttg gaccatttgt cctgaatagg gccggaggga attttggcat
     3661 ccggcatcca gtcgcttacg ggaaaattaa tcatgacttt gagaggagtt gatggttatt
     3721 tgatgatacc cagaagaacc gagaccggca cggagatgaa gcccaggcag ataatcgcgc
     3781 cgtaggcgat ggcgataaag ttgtagaagg gccggatttt gcgggaatcg acgcccacag
     3841 tctggaagat ggactgtacc ccgtggcgca gatggctgaa cagcatcaga acggccagga
     3901 tgtagaaggc ggagcaccat acgttggaga atccggtcac gatcatcttg tacacgtcaa
     3961 aggtttccac cgtaccgtcg gaaatgaagg tggtgaactg ggcggggtcg tatcccacgc
     4021 gcagggtgta ctggtacagg tggtagatca ggaacaccag gacggtcagg ccggtataga
     4081 tcatgtagcg ggaggagagc gtcgccttga tggtgttctt gaacacgtag ggttcgcggg
     4141 ccgcatggtt ttccagcttc agctggatgg tcagccagac gtggatgatg aagatcaccg
     4201 caagccccgc gcggattccc cagagggctg cttccggcat ggagtgcagg ccgtgggcgt
     4261 aggtgttgat ccattcaggg cctccgaaga tgagaaggtt gcctgccagg tgtcccgcaa
     4321 ggaacaagac caaacataac cccgtcagag ccacaatgat tttgcggccg atggaggatg
     4381 tcacgaatgt acatatggtt tttactagtg cattcatagg cgctctaatg aaataaatgc
     4441 gtcttcacag gatgcccggt tcaagcccgg atggcaagcc tcttcttgaa tttccggcgc
     4501 ttttcggatt tttgaaaagc cggggaaaga ggttgctgtt tatcagtttg gaatggttat
     4561 cattttgttg cctgttccgg cttgacgagg ctttccgcat aggcgtatcg tctgtgcatg
     4621 aaaagaagta aaaaggaagt gctggacgcg gatttcgcag cggcgcgcgc cggcgttctg
     4681 gatgtggccg catttctgga ccgggtggac cgcggggaag gggaggcgga tttccgctac
     4741 catgccctga tggatgttct tcccctcttg tccgcatccg gccccggacg cgtccgggcc
     4801 attctggaag ccctttccta cagggatgac accgtgccgg aaaccgccgc agccaaagcg
     4861 gcctgcggag ccccgaacct cagcaaataa gaatgatggc tttcatagaa cctcatatac
     4921 atatggtgtg ccgcaccacg gacgaatacc gggccatggc gcaggccggc tgcctggcgg
     4981 taggggaacc ggcgttctgg gccggttacg accgttcgtc cgcggacggt ttccgggatt
     5041 atttcgtaca gcttacggaa tgcgaacccg ccagggcggc caagttcggc atggaccatt
     5101 acacatggct gtgcatcaat cccaaggagg cgcaggacgt ggctttcgcg cgggatgtga
     5161 tgaagctgat tccggagttc attgaccggc ccaatgtcct cggcatcggg gaaatagggc
     5221 tgaaccggaa tacttcccat gaaatgacta tttttgaaga gcatctggat ctggcggtgc
     5281 gcctcaacca gcttgtgctg attcacactc cccatctgga agacaagctt aaggggaccg
     5341 taatgattct ttccgccctg aaaaaccgtc cggatctgga cccttgccgc gtgctggtgg
     5401 atcactgtga ggaacatacc ttcccgctgg tgaaggaggc cggttactgg gccgggctga
     5461 ccctttatcc caccagcaag ctgaatccca agcgggcggc ggatattctg gaattgtacg
     5521 gaatggaccg tgtctgggcc aattccgcgg cggactgggg ggattccgat cccctggcgc
     5581 tgacggccct ggcctgcgag ctgcgcaggc gcggtttttc ccggcaggaa acggaacgtc
     5641 ttctcctgga aaatccggag acattcatgg gacagtcccc gaagttccgg aaagtgtcgt
     5701 cccgttagtt ccgcccgcgg cgcggcggag ggtacggccc tctagtcccc gtccgggaaa
     5761 aagacggtga ggacggcgcc caggatgacc gccgcgtcat ccagaaggcc cagcctgccg
     5821 attccgtcaa acaggaattc gtcgggagtc aggatgtagg cgccggcggc ggccagaagg
     5881 catatattcc gtttgttgaa aaaacgcggt tctccttttc tgcttttgaa ataccggaac
     5941 aggcgcagta gcagctgctg tttttgaagg ttcatggacg ggaacggggg ataaaggttc
     6001 aagctcagcc attttcccac tccttttccc tgtttcaggg aaggagtctg ttgccgacgg
     6061 acggaaccgc agcgatccgg accgtgcggg gaaatggatt gctgaaagga tgggctgttc
     6121 cggatgctga gggaagccgg gctttgcatg ctccggttcc ggctgtcccg gcatgggaaa
     6181 aaggggcgtg tacggaagtg gggcggggcc ggaagctctt gaaatgaccc tcccggggga
     6241 gcctgaatgc catttccccg tcaagtgctg gccgtgaggg tagccagcaa atagaagctt
     6301 cttccccctg ttttttccgg cagatgtttg aacggataag gaaaaggccg gctcacgatt
     6361 ttgtgagccg gcctttgaat atagggaggc ggacggtaca ggcttatgcc ctgcggcggc
     6421 gcatcatcag cgcggccagt cccagcaggc ccagggaagc cgtggcgggt tctggaatgc
     6481 tggcgatttc actcatcagc tgaccaactt gttcctggga aaggagggag tcgtggatgt
     6541 agagctgttc gatggattca gccagtcctg cgtccatgag aatctgatta atttgctggt
     6601 tgccgaattt caggccgctg ttggaatagt acgtagcgct gtctccaaaa tagatgcggg
     6661 tgccaagatc tccggtgact acggaaatgg tcagggaacc ttccgtgccc agcggggtgt
     6721 caacgacggg cccgctgtat gaggtgttgt tccataatcc ctggagtttc cggtccgtgt
     6781 tcaggcccac gccccagctt acactgctgt ttttggcgtt aaacagagcg gtataggtct
     6841 ccggagtgtt gattttggac aggtcaagaa ccatcgtcac agacataacg tcgcggttgt
     6901 tggcaccgta tccgttgaag gttatcccgg acaacgtcag attgctgtcg tcagacgtga
     6961 tggaaacgga atctttccgg gtgccgaaat ccgccgtttg ggaggcaaag tccgaatatc
     7021 ccacgatgga gctatccaac agagcggtag ccgcggtagc gcttaggctc atgccggccg
     7081 aaagaatcag ggtggataat aatttattca tggtcagtat cttaataaaa tgattcaagg
     7141 ttcaatgtat gtacttgtgc ttgaataacg aatttggaat ccgcaagcaa ttaaaaatat
     7201 taagagttag tatattgtat ttataattca ttgaaaataa tgatttttta atatctctgg
     7261 tccttttgct aagatgacgg ggcagtcttt gttattcatt ggtttcatga ttgatttggc
     7321 ctctttttca ttacttgacg gattccaaat ccgattgggg aattccaaat tcgctacaag
     7381 ttgccatcca aaaggaataa taaatatgaa gaaaacactg acatttttaa tcgcgatggg
     7441 aagctttgct gtttcctcgg aggcagcgac cgtttttaat tattacactc ccggtacgga
     7501 taattacaat agtaccatcc atgggtttta tcttggcctg gggtcttctt ccctggctcc
     7561 ttccgattcc tcttctccct cctccctgtc cggagagatc agactggaca gttttacgct
     7621 gcgcggagcc gccaacaatt tgggcgctaa tgtcacttac ggcttcctgg tgctgaatgg
     7681 ctccgacaat tcggtcatcg gctggagcac caatacggga actactgcag cagggattaa
     7741 tctgacgttc agtttttctt ccctggatgg ttctcccctg cttcttgacg cggcattgac
     7801 ataccgtttc ctggccgtga gccagtccgt gatggacttg atgcaggata cgtctaaaac
     7861 gtatttatat gctgcggggg gaacagccgc ccctactgct aacacggaag gagataccgt
     7921 aacgatcagc ggcggattga ctgctcccgg catccgcggc cattatgacg ccgagggagc
     7981 gcctggtgat tctgtcgtta ttacgggagc caacggaacc aatactttca gcttattatc
     8041 cccgattttc acggaaatcc gaggggaaat ggtgccggaa ccagccacgg tttccctggg
     8101 cctgctggga ctggccgcgc tgatgatgcg ccgccgcagg gcttgagctt cctgatggcg
     8161 aaaaatcggc ggatgagagc tgttcttgcg gaacagctct tgttttttat atccagagag
     8221 gaagaattgc ttatccgtat gcgggattca tgccctccgg aaggtacgga atttccgggg
     8281 gcagggggcc gtatccggtt ttttccgcat ggcggcaatt tgctggaaac gtttttgaga
     8341 cgcagtaccg gaaagctttt tctttaccgg aaaatgccgt caaattcggc agcgcgcttt
     8401 tcgtccatat ggtacacagt agctttcaca tagcggcctt tcaggccgga tagggatccc
     8461 ctttgcagcg cacagacctg gagggccgcc gcatacctat tatccgccgt cctattcccc
     8521 ggcgctggta ttccggaaga acggcaatgg gccccatgcc cagcacttca tattcttttc
     8581 catcgtctgc cctgatgacg gacgttgcat caacgatgtt cccgacgatg cggctgccgt
     8641 ggatggcgac tgcatcctgc tccgggatga aggaaggact gacgcgcatg atatggagca
     8701 ggtaatgttc attgcagccg gggacgaaat agtttcagaa cgcttctctc gtgacatgtt
     8761 ccgtttcggc atggtctgag gattgttccg ttcttaatgc aatggtcatg aaagattgtt
     8821 ctttacggct cccccttgga gaaattccag aggcggtgca tcgtcataat gtccggaatg
     8881 ttcatggggc gcaccacgcg gaacccgatc atgcctccgt ccgtcaggta ccagatgctt
     8941 ttagggtttt gaggatcctg acggttccag gcgggggtgc tggcgcggcg cgcagcgctt
     9001 ctcaggctgt ccgggtcgtc ttcccacgaa ccgccgcgaa cgatgtgagg ggcgccgggg
     9061 atgatgacta gggggtcttt cgtgggcaag ccgctccgtt tgccgtaggc atccggaacg
     9121 taagagtcca aaacccattc cgccacattt ccgtgcatgt cccggagtcc ccacttattt
     9181 ggttttttag agcctgtttt ctggtagcgg tcattggaat tgttccagta ccaggcgtac
     9241 tggtccagag aggcttcccc gtttccgtaa gaataggcgc cggcggaacc ggcccggcag
     9301 gcgtattccc attccgcctc cgtgggcagg cggtagtaat gcccggtctg ggcgctcagc
     9361 cattcgcaga atttgctggc ggcgtggtgg gacatggaga tggcgggcag gccgtgttca
     9421 tagccgtggc ccatgcccag gttcatggcg gcgtaggggg cggtaggctg cgtgacggag
     9481 tcccacagtt cgtcatccgg ctgttcctcc agaagctggc cgtccttggc gcgcggacgc
     9541 ccgttttcca tgaaggccgt ataaagttcc caggggattt ccgtttccga gatccagaag
     9601 ggagagatgc tcactttatg ctgcggacct tcgtccggtt tccggtgcgg ctcttccgcg
     9661 ggactcccca tgaggaacgt tcctcccggt atggcgatca tgcgcaggga agctcccgcc
     9721 gcgggaaccg tttccgtgta ggattcaaaa cgtgccggat ttccggaagc ttcaatgagc
     9781 tgatggattt ggcgcgtcgt gccgaccagc tcccgggacg gcaggtcatc cggaatggga
     9841 agggcaggac cggcagcgcg gtccagttcc cgtttttgca gcgcggatcg gctttctccc
     9901 cactggcgtg cgctggtaat gcgcgcggca tcttccgtgg ccgggcgggg ggaattattt
     9961 tcttcccggc acccggccag cagggcgctt cctcccagaa agcaggaaac aaggaaaatg
    10021 ccgcgcatgg aatggtgaaa accggaatgc cctacatcgt catgcctccg tcgcaggcaa
    10081 tgacctgccc ggtgatgtaa cgggcatcgt cagaggcaag gaaggccgtc agggcggcga
    10141 tatcttccac ggaaccttgt tctttcaaag gtattttctt aacgatttct tccttgagat
    10201 tgtcgggaat ggcattggac atttccgtgg agatgaagcc gggagcaatg gcgttgcacg
    10261 tgactttgcg cggagcgaat tcctgagcca gtgatttggt gaaaccgatg aggcccgcct
    10321 tggaagcggc gtaattagcc tggccgatgt tgccgacgag accgatgacg gagctcatgt
    10381 tgatgatgcg cccggccggg gatttcatga gaacgcgctg gagggccttg actgtattga
    10441 acgcgctttt caggttggtg tccagaacgg catcccagtc ttcctccttc atgcggagca
    10501 tcagggagtc ccgcgtgatg ccggcgttgt tcaccaggat gtcaatctgc gggaagtctt
    10561 tcaaaatggc ggccatggtt tcctgaacgg ccgcgtaatc cgctacgtcg caggggtagg
    10621 ccttgcagga atccggaaat tccttgttga tttcttctgc ggcccccccg cagctggatg
    10681 gactgcggct gatcaggatg accctggctc cttccgaagc gaagcggcgc gcgacggcat
    10741 tgccgattcc gcggcccgcg ccggtaacga tggctgtttt acctgctaac ttttgcatgc
    10801 tgcccacagt aaacccgttt ttcacggttc cggcaagctt gaaatggact tggccgcgca
    10861 ggaacccata cggggaaagg gcgtgccggg aatgaaaaag aggggggaga aacggggcgg
    10921 ggggctactg tccggcctct tcattttccc ggagtgcatc gggggcgcac cgttttcatc
    10981 cggttctacc aggtcgctga attcatccga attttccaaa atgtcctttg aggcggcgga
    11041 accgtaatag cgggcctcaa acaggcgttt gccttcctgc ctgcagcggt tgtccagcat
    11101 ttccattcgt ttttccattt tttctatcaa ggcgtcttct ttctcctttt ccgcatcgtt
    11161 caatttatcc tgaagctgga ggaaatgccg gatgtccttc tgaatgtcct gcagcgtttt
    11221 gacggcgttg tccgcgcttt ccttgtcctg aactcctgcc aacgtctgct ggatattgat
    11281 ggcaaaggaa aaggcctggt tgatcaggga ttccgcggaa ggaatttttt ccgccggagc
    11341 cgctgctgag ggggaagccg ttccggcggc cgtttcacca aatgcaagag aggctccgga
    11401 cagaagcgca gaatataaga gaggaacaag aaaagccttc atcctgttct tttaaggcag
    11461 gatgaaatcc acggcaagga aaaaggggaa actgaaaaaa gagccttatt ccgccgtgat
    11521 gccgcctttt tcatcgtcca gaatgcctga cttttccaga tagtagtcat atccgcctgc
    11581 gtaggcggtg atggtccccc ggttcacatg cagggttttt tgtgccaggg aacggatgaa
    11641 gtgcacatcg tgggagatga agaccagtgt tccttcataa tgcttcagag cctgcaccag
    11701 ggcttctacg gacaaaaggt ccaggtgggt ggtcggctcg tccatcagca ggaggttggg
    11761 cggatccacc aggaatttga ccaggctgag ccgcgatttt tccccgccgg aaagaacgct
    11821 gacgcgtttt tccacatcca gcctccggaa caggaaggaa cccaggatgg aacgcgcttc
    11881 ttcctcccgg atttcagcgc tgcatttcat gatttcctcc agcacggtat tttccggatt
    11941 caggttttcc gttcgcgcct gggagaagta gccgatgcgc gtcgtggtac cgggagtgcg
    12001 ttgtccggag tcaatgggga tgatgcccgc caggattttg agaagagtgg atttgcccgc
    12061 gccgttcggg cctacaagaa cagtgcgctc cccgcgttcc accagcaggt ccaggttttc
    12121 ataaaccctg cggtcgccat aggattggca gactttttcc agctcaatga ctttctgggt
    12181 gctgcgcgga ggctggggga agttgaattt aaatactttc ctgcgggcta ccggtttttg
    12241 aatgattttc atcttttcca gctgcttgat gcggctctgg acttgcccgg ctttggaatt
    12301 gatggagcgg aaacggtcaa taaattcctg aatgtgcgct atttccttct gctggttacg
    12361 gtaggccgcc tgaagctgct cgaagcgcac gtccttttgt tggaggaagt ccgagtaatt
    12421 gccgcggtat tccaccagtt cttcgttgtc gatgtcgtac acgctttcca ccagctcatc
    12481 catgaaatcc cggtcgtggg aaatcatcag gatggctccg gggtagtttt tcaggtatcg
    12541 ctggagccac agcagggaca ggaggtccag gtggttggta ggttcgtcca gcatcaggag
    12601 gtccggctcc aggacaagga gcttggccag gtacgcgcgc atgatccagc cgccggacat
    12661 ttcccgggcg gggcgatgga agtcgctttc ccgaaaggcc agccctttga gaattttctt
    12721 ggctttgggc tccagctggt aaccgttggc ggcgttgaaa gtgtcaatgg cttccgcgta
    12781 ttccggcgta tccgttttgt tggcgttttc cgccgtccgg atggtgtgga tggcctgttc
    12841 catttccggc gtgatgccca gggcgatttc cagaacggtt tcatccttcg gttcgctggc
    12901 ttcctgggga agatagccca cgatggcgta ttcatccatg ctgatggagc cttcgtccgg
    12961 cgtgtcttct cccagaatca tgcggaacag ggtggatttg cctgctccgt tggggccaac
    13021 cagagccacc cgttcccccc agttaatggt catttccgtt tccctgaaca aggtccgtcc
    13081 ggcgtgggat tttgtgagat ttttgatcgt cagcatggtg aagagaggat gtattctacc
    13141 gggatggaaa ggggaaggca agagccgtca gggcggaggc tggcattttt gaaagcttta
    13201 ctggattttt acgcgtagtc tgctagcctt ggcgcgccat gccgaccacg cagacattca
    13261 ggcttttgct tgctgccgcc cttttgtgcg gatggagttc ctgctgtact cctccggcgg
    13321 aggattatat acaacaaact tacgtgcagc agcaaatgtc cgggctggct aatgccttcc
    13381 tggcgctgct gccgccggat caggcctctc ttcccgctgc cggagcggag gccaggtggc
    13441 tggcggacac ggccgtggtc cagtccgcag cgattgcccg ggacaacagg actgtgctgt
    13501 ttggctggct gaacaatatt ctggtcaatt ccaacctgcg cgacaggggg ctgtgctggc
    13561 aggtccagca ggatttgtac cgggacctgc gccgccgccc cgtgaagtat ttccgcatag
    13621 ggctgacgat tcgagaccgt ggaacgggca gggagcacag ttgcgtgtat gtcaatgccg
    13681 cggggaaggg attgcagggc tccattgttc tggatgcctg gaagaactgc gggcatctgg
    13741 tgacgctgac ccagaaggac cgggaaggcg gcaaatggga ggaggactgg cgggaaccat
    13801 ttgtttccaa ggcctttccg gagggccatt cctacggcat ggaacatcac ctggtctggc
    13861 ccgggtgggc caggaaacgc cccattctgg ttcagcggat attccagtcc gatcagcaga
    13921 atgaggcgaa ggcggccgct gaataaaggg gaagcctgat ccggcaggaa ccggcacacg
    13981 gtgctgcgcc gcggcggttt gcggtatccg ccgtttttaa ggaaaatccc ggcgaatcgg
    14041 caaatggcgg agggaatccg gactcagggc aaataaaaac gcactcagtg cgtacaccga
    14101 gtgcggatta attggataat ttgctagtgt tgcagggcaa aaccccgctg caaacttact
    14161 tgcccttggc ctgcacaacc ggagcgggag caggagcggt ggtttgctgt tgctgctgct
    14221 gctgggagca ggaagcgacc aggcaagcgg cgccggcgat ggcgaggata gcgatgttct
    14281 tcataattcg aattaaatac agtgtttgtt aactactgga acctccgcat ccacggaggt
    14341 ttgctggcac caatgtaaat ggtggcaagt agaaatcaag agattttctt gttccatgtc
    14401 acggcattac agaaaag
//
