LOCUS       c00032_gnlPro..        13713 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|DECDFHPF_32.
ACCESSION   c00032_gnlPro..
VERSION     c00032_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 10:13:29
            Original ID  :: gnl|Prokka|DECDFHPF_32
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 4612
            Orig. end    :: 18325
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13713
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[14612:18115]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      10001..13503
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13713
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13713
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             146..274
                     /locus_tag="ctg32_6"
                     /transl_table=11
                     /translation="MKNIAILAIAGAACLVASCSQQQQQQQTTAPAPAPVVQAKGK"
     CDS             complement(484..1191)
                     /locus_tag="ctg32_7"
                     /transl_table=11
                     /translation="MPTTQTFRLLLAAALLCGWSSCCTPPAEDYIQQPYVQQQMSGLAN
                     AFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNRTVLFGWLNNILVNSNLRDRG
                     LCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCVYVNAVGKGLQGSIVLDAWKN
                     CGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGMEHHLVWPGWARKRPMLVQRIF
                     QSDQQNEAKAAAE"
     CDS             1314..2924
                     /locus_tag="ctg32_8"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             2988..3506
                     /locus_tag="ctg32_9"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTAFPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESVDNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMEKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLVEPDEDGAPPGA
                     LRENEEAGQ"
     CDS             3451..4380
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg32_10"
                     /sec_met_domain="adh_short_C2 (E-value: 1.8e-75, bitscore:
                     244.0, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTGRPPVHSGKMKRPDSSPPPRFSPLFFHSRHAPSPYGFLRGQV
                     HFKLAGTVKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVARRFASEGARVILISRSPSSC
                     GGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLR
                     MKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKA
                     GLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDI
                     AALTAFLASDDARYITGQVIACDGGMTM"
     CDS             4404..5609
                     /locus_tag="ctg32_11"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSALLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPVA
                     EASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPSAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDIMTMHRLWNFSKG
                     EP"
     CDS             5623..5823
                     /locus_tag="ctg32_12"
                     /transl_table=11
                     /translation="MTIALRTEQSSDHAETEHVTREAFWNYFVPGCHEHYLLHIMRVSP
                     SFIPELDAVAVHGSRIVGKHR"
     CDS             5935..6069
                     /locus_tag="ctg32_13"
                     /transl_table=11
                     /translation="MYAAALQVCELQRGSLSGLKGHYVKAAVYHMDEKRAAEFDGISR"
     CDS             complement(6287..7027)
                     /locus_tag="ctg32_14"
                     /transl_table=11
                     /translation="MKKTLTFLIAMGSFAVSSEAATVFNYYTPGTDNYNSTIHGFYLGL
                     GSSSLAPSDSSSPSSLSGEIRLDSFTLRGAANNLGANVTYGFLVLNGSDNSVIGWSTNT
                     GTTAAGINLTFSFSSLDGSPLLLDAALTYRFLAVSQSVMDLMQDTSKTYLYAAGGTAAP
                     TANTXXXXXXXXXXLTAPGIRGHYDAEGAPGDSVVITGANGTNTFSLLSPIFTEIRGEM
                     VPEPATVSLGLLGLAALMMRRLRA"
     CDS             7322..8065
                     /locus_tag="ctg32_15"
                     /transl_table=11
                     /translation="MKKLLSTLILSAGMSLSATANTTLLDSSIVGYSDFTSQTADFGTL
                     KDSVSITSDDSNLTLSGITFNGYGTNNRDVMSVTMVLDLSKINTPETYTALFNAKNSSV
                     SWGVGLNTDRKLQGLWNNTSYSGPVVDTPLGMEGSLTISVVTGDLGTRIYFGDSATYYS
                     NSGLKFGNQQIDQILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPDPATASLGL
                     LXXXXXXXXXXXXXXXXXXXRLTKS"
     CDS             8443..8676
                     /locus_tag="ctg32_16"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(8710..9495)
                     /locus_tag="ctg32_17"
                     /transl_table=11
                     /translation="MVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSADGFRDYFVQLT
                     ECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLGIGEIGLNRNT
                     SHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLDPCRVLVDHCE
                     EHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADWGDSDPLALTA
                     LACELRRRGFSRQETERLLLENPETFMGQSPKFRKVSSR"
     CDS             complement(9528..9800)
                     /locus_tag="ctg32_18"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             10001..10702
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_19"
                     /sec_met_domain="SucD_FumR (E-value: 9.1e-14, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             10724..12685
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 154; E-value:
                     2.1e-47)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_20"
                     /sec_met_domain="FAD_binding_2 (E-value: 7.6e-48, bitscore:
                     154.0, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 4.2e-38,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFXXXXXXXXXXXXXXXXXXXXXXXXXXXXFGREYGGLLDNRSFGGAQLKR
                     TFYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGE
                     IKSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPV
                     KGDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSF
                     GNLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEE
                     ITDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALM
                     QGLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSF
                     HRELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVA
                     DFLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVL
                     HKEPLTFENVHLAIRSYK"
     CDS             12726..13256
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: 75.8; E-value: 8e-24)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_21"
                     /sec_met_domain="Fer2_3 (E-value: 2.8e-24, bitscore: 75.8,
                     seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAX
                     XXXHRLRRLRGLL"
     CDS             13198..13503
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer4_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg32_22"
                     /sec_met_domain="Fer4_7 (E-value: 1.1e-10, bitscore: 32.6,
                     seeds: 208, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 2.1e-05, bitscore: 15.6,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTRPPXXXXIGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPER
                     SKRVLAMMKQMEAEGFGNCTNQYECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
ORIGIN
        1 gggggtcctg ctcttttctg taatgccgtg acatggaaca agaaaatctc ttgatttcta
       61 cttgccacca tttacattgg tgccagcaaa cctccgtgga tgcggaggtt ccagtagtta
      121 acaaacactg tatttaattc gaattatgaa gaacatcgct atcctcgcca tcgccggcgc
      181 cgcttgcctg gtcgcttctt gctcccagca gcagcagcaa cagcaaacca ccgctcctgc
      241 tcccgctccg gttgtgcagg ccaagggcaa gtaagtttgc agcggggttt tgccctgcaa
      301 cactagcaaa ttatccaatt aatccgcact cggtgtacgc actgagtgcg tttttatttg
      361 ccctgagtcc ggattccctc cgccatttgc cgattcgccg ggattttcct taaaaacggc
      421 ggataccgca aaccgccgcg gcgcagcacc gtgtgccggt tcctgccgga tcaggcttcc
      481 cctttattca gcggccgcct tcgcctcatt ctgctgatcg gactgaaata tccgctgaac
      541 cagcatgggg cgtttcctgg cccacccggg ccagaccagg tgatgttcca tgccgtagga
      601 atggccctcc ggaaaggcct tggaaacaaa tggttcccgc cagtcctcct cccatttgcc
      661 gccttcccgg tccttctggg tcagcgtcac cagatgcccg cagttcttcc aggcatccag
      721 aacaatggag ccctgcaatc ccttccccac ggcattgaca tacacgcaac tgtgctccct
      781 gcccgttcca cggtctcgaa tcgtcagccc tatgcggaaa tacttcacgg ggcggcggcg
      841 caggtcccgg tacaaatcct gctggacctg ccagcacagc cccctgtcgc gcaggttgga
      901 attgaccaga atattgttca gccagccaaa cagcacagtc ctgttgtccc gggcaatcgc
      961 tgcggactgg accacggccg tgtccgccag ccacctggcc tccgctccgg cagcgggaag
     1021 agaggcctga tccggcggca gcagcgccag gaaggcatta gccagcccgg acatttgctg
     1081 ctgcacgtaa ggttgttgta tataatcctc cgccggagga gtacagcagg aactccatcc
     1141 gcacaaaagg gcggcagcaa gcaaaagcct gaatgtctgc gtggtcggca tggcgcgcca
     1201 aggctagcag actacgcgta aaaatccagt aaagctttca aaaatgcctg cctccgccct
     1261 gacggctctt gccttcccct ttccatcccg gtagaataca tcctctcttc accatgctga
     1321 cgatcaaaaa tctcacaaaa tcccacgccg gacggacctt gttcagggaa acggaaatga
     1381 ccattaactg gggggaacgg gtggctctgg ttggccccaa cggagcaggc aaatccaccc
     1441 tgttccgcat gattctggga gaagacacgc cggacgaagg ctccatcagc atggatgaat
     1501 acgccatcgt gggctatctt ccccaggaag ccagcgaacc gaaggatgaa accgttctgg
     1561 aaatcgccct gggcatcacg ccggaaatgg aacaggccat ccacaccatc cggacggcgg
     1621 aaaacgccaa caaaacggat acgccggaat acgcggaagc cattgacacc ttcaacgccg
     1681 ccaacggtta ccagctggag cccaaagcca aaaaaattct caaagggctg gcctttcggg
     1741 aaagcgactt ccaccgcccc gcccgggaaa tgtccggcgg ctggatcatg cgcgcgtacc
     1801 tggccaagct ccttgtcctg gagccggacc tcctgatgct ggacgaacct accaaccacc
     1861 tggacctcct gtccctgctg tggctccagc gatacctgaa aaactacccc ggagccatcc
     1921 tgatgatttc ccacgaccgg gatttcatgg atgagctggt ggaaagcgtg tacgacatcg
     1981 acaacgaaga actggtggaa taccgcggca attactcgga cttcctccaa caaaaggacg
     2041 tgcgcttcga gcagcttcag gcggcctacc gcaaccagca gaaggaaata gcgcacattc
     2101 aggaatttat tgaccgtttc cgctccatca attccaaagc cgggcaagtc cagagccgca
     2161 tcaagcagct ggaaaagatg aaaatcattc aaaaaccggt agcccgcagg aaagtattta
     2221 aattcaactt cccccagcct ccgcgcagca cccagaaagt cattgagctg gaaaaagtct
     2281 gccaatccta tggcgaccgc agggtttatg aaaacctgga cctgctggta gaacgcgggg
     2341 agcgcactgt tcttgtaggc ccgaacggcg cgggcaaatc cactcttctc aaaatcctgg
     2401 cgggcatcat ccccattgac tccggacaac gcactcccgg taccacgacg cgcatcggct
     2461 acttctccca ggcgcgaacg gaaaacctga atccggaaaa taccgtgctg gaggaaatca
     2521 tgaaatgcag cgctgaaatc cgggaggaag aagcgcgttc catcctgggt tccttcctgt
     2581 tccggaggct ggatgtggaa aaacgcgtca gcgttctttc cggcggggaa aaatcgcggc
     2641 tcagcctggt caaattcctg gtggatccgc ccaacctcct gctgatggac gagccgacca
     2701 cccacctgga ccttttgtcc gtagaagccc tggtgcaggc tctgaagcat tatgaaggaa
     2761 cactggtctt catctcccac gatgtgcact tcatccgttc cctggcacaa aaaaccctgc
     2821 atgtgaaccg ggggaccatc accgcctacg caggtggata tgactactat ctggaaaagt
     2881 caggcattct ggacgatgaa aaaggcggca tcacggcgga ataaggctct tttttcagtt
     2941 tccccttttt ccttgccgtg gatttcatcc tgccttaaaa gaacaggatg aaggcttttc
     3001 ttgttcctct cttatattct gcgcttctgt ccggagcctc tcttgcattt ggtgaaacgg
     3061 ccgccggaac ggctttcccc gcagcagcgg ctccggcgga aaaaattcct tccgcggaat
     3121 ccctgatcaa ccaggccttt tcctttgcca tcaatatcca gcagacgttg gcaggcgttc
     3181 aggacaagga aagcgtggac aacgccgtca aaacgctgca ggacattcag aaggacatcc
     3241 ggcatttcct ccagcttcag gataaattga acgatgcgga aaaggagaaa gaagacgcct
     3301 tgatagaaaa aatggaaaaa cgaatggaaa tgctggacaa ccgctgcagg caggaaggca
     3361 aacgcctgtt tgaggcccgc tattacggtt ccgccgcctt aaaggacatt ttggaaaatt
     3421 cggatgaatt cagcgacctg gtagaaccgg atgaagacgg ggcgcccccc ggtgcactcc
     3481 gggaaaatga agaggccgga cagtagcccc ccgccccgtt tctcccccct cttttttcat
     3541 tcccggcacg ccccttcccc gtatgggttc ctgcgcggcc aagtccattt caagcttgcc
     3601 ggaaccgtga aaaacgggtt tactgtgggc agcatgcaaa agttagcagg taaaacagcc
     3661 atcgttaccg gcgcgggccg cggaatcggc aatgccgtcg cgcgccgctt cgcttcggaa
     3721 ggagccaggg tcatcctgat cagccgcagt ccatccagct gcgggggggc cgcagaagaa
     3781 atcaacaagg aatttccgga ttcctgcaag gcctacccct gcgacgtagc ggattacgcg
     3841 gccgttcagg aaaccatggc cgccattttg aaagacttcc cgcagattga catcctggtg
     3901 aacaacgccg gcatcacgcg ggactccctg atgctccgca tgaaagagga agactgggat
     3961 gccgttctgg acaccaacct gaaaagcgcg ttcaatacgg tcaaggccct ccagcgcgtt
     4021 ctcatgaaat ccccggccgg gcgcatcatc aacatgagct ccgtcatcgg tctcgtcggc
     4081 aacatcggtc aggccaatta cgccgcttcc aaggcgggcc tcatcggttt caccaaatca
     4141 ctggctcagg aattcgctcc gcgcaaagtc acgtgcaacg ccattgctcc cggcttcatc
     4201 tccacggaaa tgtccaatgc cattcccgac aatctcaagg aagaaatcgt taagaaaata
     4261 cctttgaaag aacaaggttc cgtggaagat atcgccgccc tgacggcctt ccttgcctct
     4321 gacgatgccc gttacatcac cgggcaggtc attgcctgcg acggaggcat gacgatgtag
     4381 ggcattccgg ttttctccat tccatgcgcg gcattttcct tgtttcctgc tttctgggag
     4441 gaagcgccct gctggccggg tgccgggaag aaaataattc cccccgcccg gccacggaag
     4501 atgccgcgcg cattaccagc gcacgccagt ggggagaaag ccgatccgcg ctgcaaaaac
     4561 gggaactgga ccgcgctgcc ggtcctgccc ttcccattcc ggatgacctg ccgtcccggg
     4621 agctggtcgg cacaacgcgc caaatccatc agctcattga agcttccgga aatccggcac
     4681 gttttgaatc ctacacggaa acggttcccg tggcggaagc ttccctgcgc atggtcgcca
     4741 taccgggagg aacgttcctc atggggagtc ccgcggaaga gccgcaccgg aaaccggacg
     4801 aaggtccgca gcataaagtg agcatctccc ccttctggat ctcggaaacg gaaatcccct
     4861 gggaacttta tacggccttc atggaaaacg ggcgtccgcg cgccaaggac ggccagcttc
     4921 tggaggaaca gccggatgac gaactgtggg actccgttac gcagcctacc gccccctaca
     4981 ccgccatgaa cctgggcatg ggccacggct atgaacacgg tctgcccgcc atctccatgt
     5041 cccaccacgc cgccagcaaa ttctgcgaat ggctgagcgc ccagaccggg cattactacc
     5101 gcctgcccac ggaggcggaa tgggaatacg cctgccgggc cggctccccc ggcgcctatt
     5161 cttacggaaa cggggaagcc tctctggacc agtacgcctg gtactggaac aactccaatg
     5221 accgctacca gaaaacaggc tctaaaaaac caaataagtg gggactccgg gacatgcacg
     5281 gaaatgtggc ggaatgggtt ttggactctt acgttccgga tgcctacggc aaacggagcg
     5341 gcttgcccgc gaaagacccc ttggtcatca tccccagcgc ccctcacatc gttcgcggcg
     5401 gttcgtggga agacgacccg gacagcctga gaagcgctgc gcgccgcgcc agcacccccg
     5461 cctggaaccg tcaggatcct caaaacccta aaagcatctg gtacctgacg gacggaggca
     5521 tgatcgggtt ccgcgtggtg cgccccatga acattccgga cattatgacg atgcaccgcc
     5581 tctggaattt ctccaagggg gagccgtaaa gaacaacctt tcatgaccat tgcattaaga
     5641 acggaacaat cctcagacca tgccgaaacg gaacatgtca cgagagaagc gttctggaac
     5701 tatttcgtcc ccggctgcca tgaacattac ctgctccata tcatgcgcgt cagtccgtcc
     5761 ttcatcccgg agctggatgc agtcgccgtc cacggcagcc gcatcgtcgg gaaacatcgt
     5821 tgatgcaacg tccgtcatca gggcagacga tggaaaagaa tatgaagtgc tgggcatggg
     5881 gcccattgcc gttcttccga aataccagcg ccggggaata ggacggcgaa taatatgtat
     5941 gcggcggccc tccaggtctg tgagctgcaa aggggttccc tatccggcct gaaaggccac
     6001 tatgtgaaag ctgccgtgta ccatatggac gaaaagcgcg ctgccgaatt tgacggcatt
     6061 tcccggtaaa gaaaaagctt tccggtactg cgtctcaaaa acgtttccag caaattgccg
     6121 ccatgccgaa aaaaccggat acggccccct gcccccggaa attccgtacc ttccggaggg
     6181 catgaatccc gcatacggat aagcaattct tcctctctgg atataaaaaa caagagctgt
     6241 tccgcaagaa cagctctcat ccgccgattt ttcgccatca ggaagctcaa gccctgaggc
     6301 ggcgcatcat cagcgcggcc agtcccagca ggcccaggga aaccgtggct ggttccggca
     6361 ccatttcccc tcggatttcc gtgaaaatcg gggataataa gctgaaagta ttggttccgt
     6421 tggctcccgt aataacgaca gaatcaccag gcgctccctc ggcgtcataa tggccgcgga
     6481 tgccgggagc agtcaatnnn nnnnnnnnnn nnnnnnnnnn nnnntccgtg ttagcagtag
     6541 gggcggctgt tccccccgca gcatataaat acgttttaga cgtatcctgc atcaagtcca
     6601 tcacggactg gctcacggcc aggaaacggt atgtcaatgc cgcgtcaaga agcaggggag
     6661 aaccatccag ggaagaaaaa ctgaacgtca gattaatccc tgctgcagta gttcccgtat
     6721 tggtgctcca gccgatgacc gaattgtcgg agccattcag caccaggaag ccgtaagtga
     6781 cattagcgcc caaattgttg gcggctccgc gcagcgtaaa actgtccagt ctgatctctc
     6841 cggacaggga ggagggagaa gaggaatcgg aaggagccag ggaagaagac cccaggccaa
     6901 gataaaaccc atggatggta ctattgtaat tatccgtacc gggagtgtaa taattaaaaa
     6961 cggtcgctgc ctccgaggaa acagcaaagc ttcccatcgc gattaaaaat gtcagtgttt
     7021 tcttcatatt tattattcct tttggatggc aacttgtagc gaatttggaa ttccccaatc
     7081 ggatttggaa tccgtcaagt aatgaaaaag aggccaaatc aatcatgaaa ccaatgaata
     7141 acaaagattg ccccgtcatc ttgacaaaag gaccagagat attaaaaaat cattattttc
     7201 aatgaattat aaatacaata tactaactct taatattttt aattgcttgc ggattccaaa
     7261 ttcgttattc aagcgcaagt gcatacattg aatcttgcat cattttatta agatactgac
     7321 catgaagaaa ttattatcca ccctgattct ttcggccggc atgagcctga gcgccaccgc
     7381 gaataccact ctgctggata gctctatcgt gggatattcg gactttacct cccaaacggc
     7441 ggatttcggc accctgaaag attccgtttc catcacgtct gacgacagca atctgacgtt
     7501 atccgggata accttcaacg gatacggtac caacaaccgc gacgttatgt ctgtgacaat
     7561 ggttcttgat ctgtccaaaa tcaacactcc ggagacctat accgctctgt ttaacgccaa
     7621 aaacagcagt gtaagctggg gcgtgggcct gaacacggac cggaaactcc agggattatg
     7681 gaacaacacc tcatacagcg ggcccgtcgt tgacaccccg ctgggcatgg aagggtccct
     7741 gaccatttcc gtagtcaccg gagatcttgg cacccgcatc tattttggcg acagcgctac
     7801 gtactattcc aacagcggcc tgaaattcgg caaccagcaa attgatcaga ttctcatgga
     7861 cgcaggactg gctgaatcca tcgaacagct ctacatccac gactccctcc tttcccagga
     7921 acaagttggt caactgatga gtgaaatcgc cagcattccg gaccccgcca cggcttccct
     7981 gggcctgctg nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     8041 nnnnnnccgg ctcacaaaat cgtgagccgg ccttttcctt atccgttcaa acatctgccg
     8101 aaaaaacaga ggggaaaagc ttccatttgc tgcggcaacc tcacggccag cacttgacgg
     8161 aaaaatagca ttcagtctcc cccggtaggg tcatttcaag agcttccggc cccgccccac
     8221 ttccgtacac gccccttttt cccatgccgg gacagccgga accggagcat gcaaagcccg
     8281 gcttccctca gcatccggaa cagcccatcc tttcagcaat ccatttcccc gcacggtccg
     8341 gatcgctgcg gttccgtccg tcggcaacag actccttccc cgaaacaggg aaaaggagtg
     8401 ggaaaatggc tgagcttgaa cctttatccc ccgttcccgt ccatgaacct tcaaaaacag
     8461 cagctgctac tgcgcctgtt ccggtatttc aaaagcagaa aaggagaacc gcgttttttc
     8521 aacaaacgga atatatgcct tctggccgcc gccggcgcct acatcctgac tcccgacgaa
     8581 ttcctgtttg acggaatcgg caggctgggc cttctggatg acgcggcggt catcctgggc
     8641 gccgtcctca ccgtcttttt cccggacggg gactagaggg ccgtaccctc cgccgcgcct
     8701 cgggcggaat tagcgggacg acactttccg gaacttcggg gactgtccca tgaatgtctc
     8761 cggattttcc aggagaagac gttccgtttc ctgccgggaa aaaccgcgcc tgcgcagctc
     8821 gcaggccagg gccgtcagcg ccaggggatc ggaatccccc cagtccgccg cggaattggc
     8881 ccagacacgg tccattccgt acaattccag aatatccgcc gcccgcttgg gattcagctt
     8941 actggtggga taaagggtca gcccggccca gtaaccggcc tccttcacca gcgggaaggt
     9001 atgttcctca cagtgatcca ccagcacgcg gcaagggtcc agatccggac ggtttttcag
     9061 ggcggaaaga atcattacgg tccccttaag cttgtcttcc agatggggag tgtgaatcag
     9121 cacaagctgg ttgaggcgca ccgccagatc cagatgctct tcaaaaatag tcatttcatg
     9181 ggaagtattc cggttcagcc ctatttcccc gatgccgagg acattgggcc ggtcaatgaa
     9241 ctccggaatc agtttcatca catcccgcgc gaaagccacg tcctgcgcct ccttgggatt
     9301 gatgcacagc catgtgtaat ggtccatgcc gaacttggcc gccctggcgg gttcgcattc
     9361 cgtaagctgt acgaaataat cccggaaacc gtccgcggac gaacggtcgt aaccggccca
     9421 gaacgccggt tcccctaccg ccaggcagcc ggcctgcgcc atggcccggt attcgtccgt
     9481 ggtgcggcac accatatgta tatgaggttc tatgaaagcc atcattctta tttgctgagg
     9541 ttcggggctc cgcaggccgc tttggctgcg gcggtttccg gcacggtgtc atccctgtag
     9601 gaaagggctt ccagaatggc ccggacgcgt ccggggccgg atgcggacaa gaggggaaga
     9661 acatccatca gggcatggta gcggaaatcc gcctcccctt ccccgcggtc cacccggtcc
     9721 agaaatgcgg ccacatccag aacgccggcg cgcgccgctg cgaaatccgc gtccagcacc
     9781 tcctttttac ttcttttcat gcacagacga tacgcctatg cggaaagcct cgtcaagccg
     9841 gaacaggcaa caaaatgata accattccaa actgataaac agcaacctct ttccccggtt
     9901 tttcaaaaat ccgaaaagcg ccggaaattc aagaagaggc ttgccatccg ggcttgaacc
     9961 gggcatcctg tgaagacgca tttatttcat tagagcgcct atgaatgcac tagtaaaaac
    10021 catatgtaca ttcgtgacat cctccatcgg ccgcaaaatc attgtggctc tgacggggtt
    10081 atgtttggtc ttgttccttg cgggacacct ggcaggcaac cttctcatct tcggaggccc
    10141 tgaatggatc aacacctacg cccacggcct gcactccatg ccggaagcag ccctctgggg
    10201 aatccgcgcg gggcttgcgg tgatcttcat catccacgtc tggctgacca tccagctgaa
    10261 gctggaaaac catgcggccc gcgaacccta cgtgttcaag aacaccatta aggcaacgct
    10321 ctcctcccgc tacatgatct ataccggttt gaccgtcctg gtgttcctga tctaccacct
    10381 gtaccagtac accctgcgcg tgggatacga ccccgcccag ttcaccacct ttatttccga
    10441 cggtacggtg gaaacctttg acgtgtacaa gatgatcgtg accggattct ccaacgtatg
    10501 gtgctccgcc ttctacatcc tggccgttct gatgctgttc agccatctac gccacggggt
    10561 acagtccatc ttccagactg tgggcgtcga ttcccgcaaa atccggccct tctacaactt
    10621 tatcgccatc gcctacggcg cgattatctg cctgggcttc atctccgtgc cggtctcggt
    10681 tcttctgggt atcatcaaat aaccatcaac tcctctcaaa gtcatgatta attttcccgt
    10741 aagcgactgg atgccggatg ccaaaattcc ctccggccct attcaggaca aatggtccaa
    10801 gtacaaactt gagtccaaac tgatcaatcc gaacaacaag cgcaagtaca cggtgcttgt
    10861 ggtaggttcc ggcctggctg gcgcctccgc tgccgccacg cttgccgaac ttggctacaa
    10921 cgtcaaatgc ttctgctacc aggacagccc ccgccgcgcc cactccattg cggcccaggg
    10981 cggcattaac gcagccaaga actaccagaa cgacggcgac tccgtttacc gcctgtttta
    11041 cgacaccgtt aaaggcggcg acttcnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
    11101 nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnncct tcggccgtga
    11161 atacggcggc ctgctggaca accgctcctt cggcggcgcc cagctcaagc gaaccttcta
    11221 cgcacgcgga cagacgggcc agcagctcct gctgggtgcc taccaggccc tggaaaagga
    11281 agtggccaag ggacacattg aaatgttctc ccgccatgaa atgatggatc tggtgctggt
    11341 ggacggcgaa gccaagggca tcgtcacccg caatctggtt accggcgaaa tcaaatccta
    11401 cgcaggggat accgtcctgc tctgcacggg cggctacggc aacgtgttct tcctgtccac
    11461 caacgcgatg ggctgcaacg tcactgccgc ctacaaggcc tacaagcgcg gtgccttctt
    11521 cgccaacccc tgcttcacgc aaatccaccc cacctgcatt ccggtcaagg gcgactacca
    11581 gtccaaactg acgctgatgt cggaatccct ccgcaacagt ggccgcatct gggtgcccaa
    11641 gtcccgtgaa accgcagaaa aaatccgtaa aaaggaaatc aagccttccg atgttcccga
    11701 agaagaacgg gactactacc tggaacgcaa gtatccctcc ttcggcaacc tggctccgcg
    11761 cgacatttcc tcccgcgccg ccaaggaagc ctgcgacgac ggccgcggcg tggccgtcac
    11821 cggcaagggc gtcttcctgg attttgcgga tgaaatcaag cgcatgggcc gcgaatggat
    11881 tgacggccaa tacggcaatc tgtttgacat gtacgaagaa atcacggacg acgaccccca
    11941 tgaaacgccc atgatgatct accccgcctc ccactacacc atgggcggcc tgtgggtgga
    12001 ctacaacctc atgtccaacg tgaaggggct gcacgtcctc ggtgaagcca acttctccga
    12061 ccacggcgcc aaccgcctgg gagcctccgc cctgatgcag ggcctgtctg acggctactt
    12121 cgtcattccc gccacgttgc ccgcttacct gacgaccacc aagcccggcg ccgtcaccac
    12181 cgccgccccg gaattcaagg ctgcggaaga cgaagtgaag gaacgcatca acaagctcct
    12241 gaatgtgaag ggcaccaaga cggtggactc cttccaccgg gaactgggcc tcatcatgtg
    12301 ggaagactgc ggcatggccc gcacggaaga aagcctgacc cacgccattg aacgcattcc
    12361 ccagctccgc aaggaattct gggaaaacgt gcgcgtaacc ggcacggcgg acggcatcaa
    12421 cgcggaactg gaaaaagcct gccgcgtggc cgacttcctg gaattcgccc agctgctctg
    12481 ctatgacgcc ctgaaccgcc aggaatcctg cggcgcccac ttccgcgtgg aataccagct
    12541 gccggacggc gaagccaagc gcaacgacga tgaatacgcc tatgtagccg cctgggaata
    12601 cactggcgtg gacagcctgc ctgttctcca caaggaaccg ctgaccttcg agaacgtgca
    12661 ccttgccatc cgcagctaca agtaaagata gccaatacat taacactcaa aagaaagatt
    12721 ataacatggc taaaacactc aatctcactc tcaaggtctg gcgccaggaa aaccgggaag
    12781 ccaagggccg cattgagacc tatgccgcca aggacattcc ggtggacgcc tccttcctgg
    12841 aaatgctgga catcgtcaat gaaggcctgg tcaaggaagg caaggaaccc atccattttg
    12901 accacgactg ccgggaaggc atctgcggca tgtgctccct gaccatcaac ggcattcccc
    12961 acgggccgga acgccaggtg accacttgcc agcttcacat gcgcaagttc aaggacggcg
    13021 ataccgtctg gattgaaccc ttccgcgcga aggctttccc aatcctgcgg gacctgatgg
    13081 tggaccgctc cgccctggac cgcatcatcg ccgccggagg ctatattgac gtgcgtaccg
    13141 gttccgcgcc gaacgccaac aacatcgccg tggaaaaagt gaaggcggac gccgcctttg
    13201 acgcggccgc ctgnnnnnnn nnncatcggc tgcggcgcct gcgtggcctc ctgtaaaaac
    13261 gcttccgcca tgctgttcac ctccgccaag atcgcccatc tcaatctgct gccgcagggc
    13321 cagccggaac gttccaagcg cgtcctggcc atgatgaagc agatggaagc ggaaggcttt
    13381 ggcaactgca cgaaccagta tgaatgtgaa gccgcctgcc cgaaaggcat cagcgtggac
    13441 aacatcgccc gcctcaaccg cgacttcatg cgggccaacg ccaaggaagg cctctgtttc
    13501 taaagaagat tccttcttaa gacgctctgt aaaaactccc ggcggcatcg gctgtcggga
    13561 gttttttcat taccagattt ccttgaacca ggaataaaat accagacagt tgcttcctca
    13621 tcgtcgcgca gcgtaaaaaa ttgttacacc ggaaggcacc cagtaatcca ggaaaccgta
    13681 cttggaaatg ccggacgaaa cctaagcagg ccc
//
