LOCUS       c00014_gnlPro..        13689 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|GPCOAFML_14.
ACCESSION   c00014_gnlPro..
VERSION     c00014_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 15:34:52
            Original ID  :: gnl|Prokka|GPCOAFML_14
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13689
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..13689
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[199:3689]"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      200..3689
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /neighbourhood="10000"
                     /product="Fumarate2succinate"
                     /protocluster_number="1"
     cand_cluster    1..13689
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Succ_DH_flav_C and FAD_binding_2 and
                     (Fer2_3 or Fer4_7 or SucD_FumR))"
                     /kind="single"
                     /product="Fumarate2succinate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..13689
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="Fumarate2succinate"
                     /region_number="1"
                     /rules="(Succ_DH_flav_C and FAD_binding_2 and (Fer2_3 or
                     Fer4_7 or SucD_FumR))"
                     /tool="gutsmash"
     CDS             complement(200..967)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Fer2_3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_8"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fer4_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1052:Succinate dehydrogenase-2Fe-2S iron-sulfur
                     cluster binding domain (Score: -1.5; E-value: 8.6)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_1"
                     /sec_met_domain="Fer2_3 (E-value: 2.1e-23, bitscore: 74.4,
                     seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_8 (E-value: 7.2e-11, bitscore: 34.5,
                     seeds: 153, tool: rule-based-clusters)"
                     /sec_met_domain="Fer4_4 (E-value: 4.1e-06, bitscore: 19.2,
                     seeds: 79, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAKTLNLTLKVWRQENREAKGRIETYAAKDIPVDASFLEMLDIVN
                     EGLVKEGKEPIHFDHDCREGICGMCSLTINGIPHGPERQVTTCQLHMRKFKDGDTVWIE
                     PFRAKAFPILRDLMVDRSALDRIIAAGGYIDVRTGSAPNANNIAVEKVKADAAFDAAAC
                     IGCGACVASCKNASAMLFTSAKIAHLNLLPQGQPERSKRVLAMMKQMEAEGFGNCTNQY
                     ECEAACPKGISVDNIARLNRDFMRANAKEGLCF"
     CDS             complement(1008..2966)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: FAD_binding_2"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: Succ_DH_flav_C"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1027:FAD binding domain (Score: 176.1; E-value:
                     4.2e-54)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_2"
                     /sec_met_domain="FAD_binding_2 (E-value: 4e-54, bitscore:
                     176.1, seeds: 62, tool: rule-based-clusters)"
                     /sec_met_domain="Succ_DH_flav_C (E-value: 1.1e-37,
                     bitscore: 120.8, seeds: 739, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINFPVSDWMPDAKIPSGPIQDKWSKYKLESKLINPNNKRKYTVL
                     VVGSGLAGASAAATLAELGYNVKCFCYQDSPRRAHSIAAQGGINAAKNYQNDGDSVYRL
                     FYDTVKGGDFRAREANVYRLAEVSSNIIDQCVAQGVPFGREYGGLLDNRSFGGAQLKRT
                     FYARGQTGQQLLLGAYQALEKEVAKGHIEMFSRHEMMDLVLVDGEAKGIVTRNLVTGEI
                     KSYAGDTVLLCTGGYGNVFFLSTNAMGCNVTAAYKAYKRGAFFANPCFTQIHPTCIPVK
                     GDYQSKLTLMSESLRNSGRIWVPKSRETAEKIRKKEIKPSDVPEEERDYYLERKYPSFG
                     NLAPRDISSRAAKEACDDGRGVAVTGKGVFLDFADEIKRMGREWIDGQYGNLFDMYEEI
                     TDDDPHETPMMIYPASHYTMGGLWVDYNLMSNVKGLHVLGEANFSDHGANRLGASALMQ
                     GLSDGYFVIPATLPAYLTTTKPGAVTTAAPEFKAAEDEVKERINKLLNVKGTKTVDSFH
                     RELGLIMWEDCGMARTEESLTHAIERIPQLRKEFWENVRVTGTADGINAELEKACRVAD
                     FLEFAQLLCYDALNRQESCGAHFRVEYQLPDGEAKRNDDEYAYVAAWEYTGVDSLPVLH
                     KEPLTFENVHLAIRSYK"
     CDS             complement(2988..3689)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     Fumarate2succinate: SucD_FumR"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg14_3"
                     /sec_met_domain="SucD_FumR (E-value: 2.5e-13, bitscore:
                     42.0, seeds: 10, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNALVKTICTFVTSSIGRKIIVALTGLCLVLFLAGHLAGNLLIFG
                     GPEWINTYAHGLHSMPEAALWGIRAGLAVIFIIHVWLTIQLKLENHAAREPYVFKNTIK
                     ATLSSRYMIYTGLTVLVFLIYHLYQYTLRVGYDPAQFTTFISDGTVETFDVYKMIVTGF
                     SNVWCSAFYILAVLMLFSHLRHGVQSIFQTVGVDSRKIRPFYNFIAIAYGAIICLGFIS
                     VPVSVLLGIIK"
     CDS             3890..4162
                     /locus_tag="ctg14_4"
                     /transl_table=11
                     /translation="MKRSKKEVLDADFAAARAGVLDVAAFLDRVDRGEGEADFRYHALM
                     DVLPLLSASGPGRVRAILEALSYRDDTVPETAAAKAACGAPNLSK"
     CDS             4165..4980
                     /locus_tag="ctg14_5"
                     /transl_table=11
                     /translation="MMAFIEPHIHMVCRTTDEYRAMAQAGCLAVGEPAFWAGYDRSSAD
                     GFRDYFVQLTECEPARAAKFGMDHYTWLCINPKEAQDVAFARDVMKLIPEFIDRPNVLG
                     IGEIGLNRNTSHEMTIFEEHLDLAVRLNQLVLIHTPHLEDKLKGTVMILSALKNRPDLD
                     PCRVLVDHCEEHTFPLVKEAGYWAGLTLYPTSKLNPKRAADILELYGMDRVWANSAADW
                     GDSDPLALTALACELRRRGFSRQETERLLLENPETFMGQSSKFRKVSSR"
     CDS             complement(5014..5247)
                     /locus_tag="ctg14_6"
                     /transl_table=11
                     /translation="MNLQKQQLLLRLFRYFKSRKGEPRFFNKRNICLLAAAGAYILTPD
                     EFLFDGIGRLGLLDDAAVILGAVLTVFFPDGD"
     CDS             complement(5679..6347)
                     /locus_tag="ctg14_7"
                     /transl_table=11
                     /translation="MSLSATAATSLLDSSIVGYSDFASQTADFGTLKDSVSITSDDSNL
                     TLSGITFNGYGANNRDVMSVTMVLDLSKINTPDAYTALFNAKNSSVSWGVGLNTDRKLQ
                     GLWNNTSYSGPVVDTPLGTEGSLTISVVTGDLGTRIYFGDSATYYSNSGLKFGNQQIDQ
                     ILMDAGLAESIEQLYIHDSLLSQEQVGQLMSEIASIPEPATASLGLLGLAALMMRRRRA
                     "
     CDS             complement(6417..6506)
                     /locus_tag="ctg14_8"
                     /transl_table=11
                     /translation="MNYKYNILTLNIFNCLRIPNSLFKHKYIH"
     CDS             complement(6803..7228)
                     /locus_tag="ctg14_9"
                     /transl_table=11
                     /translation="MPGAVNPPLIVTVSPSVLAVGAAVPPAEYKYVLDVSCIKSITDWL
                     TARKRYVNAASRSRGEPSREEKLNVRLIPAAVVPVLVLQPMXXXXXXXXXXXXXXXXXP
                     KLLAAPRSVKLSSLISPDREEGEEESEGAREEDPRLR"
     CDS             complement(7523..7960)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acetyltransf_1"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_10"
                     /sec_met_domain="Acetyltransf_1 (E-value: 1.9e-08,
                     bitscore: 26.6, seeds: 223, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGPIAVLPEYQRQGIGRRMIGYTRNRAREMGFRAIFLYGDPDYSS
                     HCGFVPAETLGIRTADNRYAAALQVCALQRGSLSGLKGRYVEAAVYHMDEKRAAEFDRH
                     FPVKKKLSGIASQKRFQQIAAMRKKPDTAPCPRKSRTFRRA"
     CDS             complement(8013..8213)
                     /locus_tag="ctg14_11"
                     /transl_table=11
                     /translation="MIIALRTEQSADHAETEHVTREALWNYFVPGCNEHYLLHIMRVSP
                     SFISELDTVAVHGSRIVGKHR"
     CDS             complement(8227..9432)
                     /locus_tag="ctg14_12"
                     /transl_table=11
                     /translation="MRGIFLVSCFLGGSVLLAGCREENNSPRPATEDAARITSARQWGE
                     SRSALQKRELDRAAGPALPIPDDLPSRELVGTTRQIHQLIEASGNPARFESYTETVPAA
                     GASLRMVAIPGGTFLMGSPAEEPHRKPDEGPQHKVSISPFWISETEIPWELYTAFMENG
                     RPRAKDGQLLEEQPDDELWDSVTQPTAPYTAMNLGMGHGYEHGLPAISMSHHAASKFCE
                     WLSAQTGHYYRLPTEAEWEYACRAGSPGAYSYGNGEASLDQYAWYWNNSNDRYQKTGSK
                     KPNKWGLRDMHGNVAEWVLDSYVPDAYGKRSGLPAKDPLVIIPGAPHIVRGGSWEDDPD
                     SLRSAARRASTPAWNRQDPQNPKSIWYLTDGGMIGFRVVRPMNIPDVMTMHRLWNFSKG
                     EP"
     CDS             complement(9456..10385)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg14_13"
                     /sec_met_domain="adh_short_C2 (E-value: 9.3e-75, bitscore:
                     243.1, seeds: 358, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKTGRTPVHSGKMKRPDSSPPPRFSPLFFHSRHALSPYGFLRGQV
                     HFKLAGTVKNGFTVGSMQKLAGKTAIVTGAGRGIGNAVAHRFASEGARVILISRSPSSC
                     GGAAEEINKEFPDSCKAYPCDVADYAAVQETMAAILKDFPQIDILVNNAGITRDSLMLR
                     MKEEDWDAVLDTNLKSAFNTVKALQRVLMKSPAGRIINMSSVIGLVGNIGQANYAASKA
                     GLIGFTKSLAQEFAPRKVTCNAIAPGFISTEMSNAIPDNLKEEIVKKIPLKEQGSVEDI
                     AALTAFLASDDARYITGQVIACDGGMTM"
     CDS             complement(10330..10848)
                     /locus_tag="ctg14_14"
                     /transl_table=11
                     /translation="MKAFLVPLLYSALLSGASLAFGETAAGTASPAAAAPAEKIPSAES
                     LINQAFSFAINIQQTLAGVQDKESADNAVKTLQDIQKDIRHFLQLQDKLNDAEKEKEDA
                     LIEKMKKRMEMLDNRCRQEGKRLFEARYYGSAALKDILENSDEFSDLAEPDEDGAHPGA
                     LRENEEAGQ"
     CDS             complement(10912..12522)
                     /locus_tag="ctg14_15"
                     /transl_table=11
                     /translation="MLTIKNLTKSHAGRTLFRETEMTINWGERVALVGPNGAGKSTLFR
                     MILGEDTPDEGSISMDEYAIVGYLPQEASEPKDETVLEIALGITPEMEQAIHTIRTAEN
                     ANKTDTPEYAEAIDTFNAANGYQLEPKAKKILKGLAFRESDFHRPAREMSGGWIMRAYL
                     AKLLVLEPDLLMLDEPTNHLDLLSLLWLQRYLKNYPGAILMISHDRDFMDELVESVYDI
                     DNEELVEYRGNYSDFLQQKDVRFEQLQAAYRNQQKEIAHIQEFIDRFRSINSKAGQVQS
                     RIKQLEKMKIIQKPVARRKVFKFNFPQPPRSTQKVIELEKVCQSYGDRRVYENLDLLVE
                     RGERTVLVGPNGAGKSTLLKILAGIIPIDSGQRTPGTTTRIGYFSQARTENLNPENTVL
                     EEIMKCSAEIREEEARSILGSFLFRRLDVEKRVSVLSGGEKSRLSLVKFLVDPPNLLLM
                     DEPTTHLDLLSVEALVQALKHYEGTLVFISHDVHFIRSLAQKTLHVNRGTITAYAGGYD
                     YYLEKSGILDDEKGGITAE"
     CDS             12762..13352
                     /locus_tag="ctg14_16"
                     /transl_table=11
                     /translation="MSGLANAFLALLPPDQASLPAAGAEARWLADTAVVQSAAIARDNR
                     TVLFGWLNNILVNSNLRDRGLCWQVQQDLYRDLRRRPVKYFRIGLTIRDRGTGREHSCV
                     YVNAVGKGLQGSIVLDAWKNCGHLVTLTQKDREGGKWEEDWREPFVSKAFPEGHSYGME
                     HHLVWPGWARKRPMLVQRIFQSDQQNEAKAAAE"
     CDS             complement(13555..13683)
                     /locus_tag="ctg14_17"
                     /transl_table=11
                     /translation="MKNIAILAIAGAACLVASCSQQQQQQQTTAPAPAPVVQAKGK"
ORIGIN
        1 ggtttcgtcc ggcatttcca agtacggtct cctggattac tggaaccctt ccggtgtaac
       61 aattttttac gctgcgcgac gatgaggaag caactgtctg atattttatt cctggttcaa
      121 ggaaatctgg taatgaaaaa actcccgaca gccgatgccg ccgggagttt ttacagagcg
      181 tcttaagaag gaatcttctt tagaaacaga ggccttcctt ggcgttggcc cgcatgaagt
      241 cgcggttgag gcgggcgatg ttgtccacgc tgatgccttt cgggcaggcg gcttcacatt
      301 catactggtt cgtgcagttg ccaaagcctt ccgcttccat ctgcttcatc atggccagga
      361 cgcgcttgga acgttccggc tggccctgcg gcagcagatt gagatgggcg atcttggcgg
      421 aggtgaacag catggcggag gcgtttttac aggaggccac gcaggcgccg cagccgatgc
      481 aggcggccgc gtcaaaggcg gcgtccgcct tcactttttc cacggcgatg ttgttggcgt
      541 tcggcgcgga accggtacgc acgtcaatat agcctccagc ggcgatgatg cggtccaggg
      601 cggagcggtc caccatcagg tcccgcagga ttgggaaagc cttcgcgcgg aagggttcaa
      661 tccagacggt atcgccatcc ttgaacttgc gcatgtgaag ctggcaagtg gtcacctggc
      721 gttccggccc gtggggaatg ccgttgatgg tcagggagca catgccgcag atgccttccc
      781 ggcagtcgtg gtcaaaatgg atgggttcct tgccttcctt gaccaggcct tcattgacga
      841 tgtccagcat ttccaggaag gaggcgtcca ccggaatgtc cttggcggca taggtctcaa
      901 tgcggccctt ggcttcccgg ttttcctggc gccagacctt gagagtgaga ttgagtgttt
      961 tagccatgtt ataatctttc ttttgagtgt taatgtattg gctatcttta cttgtagctg
     1021 cggatggcaa ggtgcacgtt ctcgaaggtc agcggttcct tgtggagaac aggcaggctg
     1081 tccacgccag tgtattccca ggcggctaca taggcgtatt catcgtcgtt gcgcttagct
     1141 tcgccgtccg gcagctggta ttccacgcgg aagtgggcgc cgcaggattc ctggcggttc
     1201 agggcgtcat agcagagcag ctgggcgaat tccaggaagt cggccacgcg gcaggctttt
     1261 tccagttccg cgttgatgcc gtccgccgtg ccggttacgc gcacgttttc ccagaattcc
     1321 ttgcggagct ggggaatgcg ttcaatggcg tgggtcaggc tttcttccgt gcgggccatg
     1381 ccgcagtctt cccacatgat gaggcccagt tcccggtgga aggagtccac cgtcttggtg
     1441 cccttcacat tcaggagctt gttgatgcgt tccttcactt cgtcttccgc agccttgaat
     1501 tccggggcgg cggtggtgac ggcgccgggc ttggtggtcg tcaggtaagc gggcagcgtg
     1561 gcgggaatga cgaagtagcc gtcagacagg ccctgcatca gggcggaggc tcccaggcgg
     1621 ttggcgccgt ggtcggagaa gttggcttca ccaaggacgt gcagcccctt cacgttggac
     1681 atgaggttgt agtccaccca caggccgccc atggtgtagt gggaggcggg gtagatcatc
     1741 atgggcgttt catgggggtc gtcgtccgtg atttcttcgt acatgtcaaa cagattgccg
     1801 tattggccgt caatccattc gcggcccatg cgcttgattt catccgcaaa atccaggaag
     1861 acgcccttgc cggtgacggc cacgccgcgg ccgtcgtcgc aggcttcctt ggcggcgcgg
     1921 gaggaaatgt cgcgcggagc caggttgccg aaggacggat acttgcgttc caggtagtag
     1981 tcccgttctt cttcgggaac atcggaaggc ttgatttcct tcttacggat tttttctgcg
     2041 gtttcacggg acttgggcac ccagatgcgg ccactgttgc gtagggattc cgacatcagc
     2101 gtcagtttgg actggtagtc gcccttgacc ggaatgcagg tggggtggat ttgcgtgaag
     2161 caggggttgg cgaagaaggc accgcgcttg taggctttgt aggcggcagt gacgttgcaa
     2221 cccatcgcgt tggtggacag gaagaacacg ttgccgtagc cgcccgtgca gagcaggacg
     2281 gtatcccctg cgtaggattt gatttcgccg gtaaccagat tgcgggtgac gatgcccttg
     2341 gcttcgccgt ccaccagcac cagatccatc atttcatggc gggagaacat ttcaatgtgt
     2401 cccttggcca cttccttttc cagggcctgg taggcaccca gcaggagctg ctggcccgtc
     2461 tgtccgcgtg cgtagaaggt tcgcttgagc tgggcgccgc cgaaggagcg gttgtccagc
     2521 aggccgccgt attcacggcc gaagggaacg ccctgggcca cacactggtc aatgatgttg
     2581 gaggaaactt ccgccagacg gtagacattg gcttcacggg cgcggaagtc gccgccttta
     2641 acggtgtcgt aaaacaggcg gtaaacggag tcgccgtcgt tctggtagtt cttggccgcg
     2701 ttaatgccgc cctgggccgc aatggagtgg gcgcggcggg ggctgtcctg gtagcagaag
     2761 catttgacgt tgtagccaag ttcggcaagc gtggcggcag cggaggcgcc agccaggccg
     2821 gaacctacca caagcaccgt gtacttgcgc ttgttgttcg gattgatcag tttggactca
     2881 agtttgtact tggaccattt gtcctgaata gggccggagg gaattttggc atccggcatc
     2941 cagtcgctta cgggaaaatt aatcatgact ttgagaggag ttgatggtta tttgatgata
     3001 cccagaagaa ccgagaccgg cacggagatg aagcccaggc agataatcgc gccgtaggcg
     3061 atggcgataa agttgtagaa gggccggatt ttgcgggaat cgacgcccac agtctggaag
     3121 atggactgta ccccgtggcg cagatggctg aacagcatca gaacggccag gatgtagaag
     3181 gcggagcacc atacgttgga gaatccggtc acgatcatct tgtacacgtc aaaggtttcc
     3241 accgtaccgt cggaaatgaa ggtggtgaac tgggcggggt cgtatcccac gcgcagggtg
     3301 tactggtaca ggtggtagat caggaacacc aggacggtta gaccggtata gatcatgtag
     3361 cgggaggaga gcgttgcctt gatggtgttc ttgaacacgt agggttcgcg ggccgcatgg
     3421 ttttccagct tcagctggat ggtcagccag acgtggatga tgaagatcac cgcaagcccc
     3481 gcgcggattc cccagagggc tgcttccggc atggagtgca ggccgtgggc gtaggtgttg
     3541 atccattcag ggcctccgaa gatgagaagg ttgcctgcca ggtgtcccgc aaggaacaag
     3601 accaaacata accccgtcag agccacaatg attttgcggc cgatggagga tgtcacgaat
     3661 gtacatatgg tttttactag tgcattcata ggcgctctaa tgaaataaat gcgtcttcac
     3721 aggatgcccg gttcaagccc ggatggcaag cctcttcttg aatttccggc gtttttcgga
     3781 tttttgaaaa gccggggaaa gatgttgctg tttatcagtt tggaatggtt atcattttgt
     3841 tgcctgttcc ggcttgacga ggctttccgc ataggcgtat cgtctgtgca tgaaaagaag
     3901 taaaaaggag gtgctggacg cggatttcgc agcggcgcgc gccggcgttc tggatgtggc
     3961 cgcatttctg gaccgggtgg accgcgggga aggggaggcg gatttccgct accatgccct
     4021 gatggatgtt cttcccctct tatccgcatc cggccccgga cgcgtccggg ccattctgga
     4081 agccctttcc tacagggatg acaccgtgcc ggaaaccgcc gcagccaaag cggcctgcgg
     4141 agccccgaac ctcagcaaat aagaatgatg gctttcatag aacctcatat acatatggtg
     4201 tgccgcacca cggacgaata ccgggccatg gcgcaggccg gctgcctggc ggtaggggaa
     4261 ccggcgttct gggccggtta cgaccgttcg tccgcggacg gtttccggga ttatttcgta
     4321 cagcttacgg aatgcgaacc cgccagggcg gccaagttcg gcatggacca ttacacatgg
     4381 ctgtgcatca atcccaagga ggcgcaggac gtggctttcg cgcgggatgt gatgaaactg
     4441 attccggagt tcattgatcg gcccaatgtc ctcggcatcg gggaaatagg gctgaaccgg
     4501 aatacttccc atgaaatgac tatttttgaa gagcatctgg atctggcggt gcgcctcaac
     4561 cagcttgtgc tgattcacac tccccatctg gaagacaagc ttaaggggac cgtaatgatt
     4621 ctttccgccc tgaaaaaccg tccggatctg gacccttgcc gcgtgctggt ggatcactgt
     4681 gaggaacata ccttcccgct ggtgaaggag gccggttact gggccgggct gaccctttat
     4741 cccaccagta agctgaatcc caagcgggcg gcggatattc tggaattgta cggaatggac
     4801 cgtgtctggg ccaattccgc ggcggactgg ggggattccg atcccctggc gctgacggcc
     4861 ctggcctgcg agctacgcag gcgcggtttt tcccggcagg aaacggaacg tcttctcctg
     4921 gaaaatccgg agacattcat gggacagtcc tcgaagttcc ggaaagtgtc gtcccgctaa
     4981 ttccgcccga ggcgcggcgg agggtacggc cctctagtcc ccgtccggga aaaagacggt
     5041 gaggacggcg cccaggatga ccgccgcgtc atccagaagg cccagcctgc cgattccgtc
     5101 aaacaggaat tcgtcgggag tcaggatgta ggcgccggcg gcggccagaa ggcatatatt
     5161 ccgtttgttg aaaaaacgcg gttctccttt tctgcttttg aaataccgga acaggcgcag
     5221 tagtagctgc tgtttttgaa ggttcatgga cgggaacggg ggataaaggt tcaagctcag
     5281 ccattttccc actccttttc cctgtttcgg ggaaggagtc tgctgccgac ggacggaaac
     5341 cgcagcgatc cggaccgtgc ggggaaatgg attgctgaaa ggatgggctg ttccggatgc
     5401 tgagggaagc cgggctttgc atgctccggt tccggctgtc ccggcatggg aaaaaggggc
     5461 gtgtacggaa gtggggcggg gccggaagct cttgaaatga ccctcccggg ggagcctgaa
     5521 tgccatttcc ccgtcaagtg ctggccgtga gggtaccgca gcaaatggaa acttcttccc
     5581 ccctgttttt tccggcagat gtttgaacgg ataaggaaaa ggccggctca cgattttgtg
     5641 agccggcctt tgaatatagg gaggcggacg gtacaggctt atgccctgcg gcggcgcatc
     5701 atcagcgcgg ccagtcccag caggcccagg gaagccgtgg cgggttccgg gatgctggcg
     5761 atttcactca tcagctgacc aacttgttcc tgggaaagga gggagtcgtg aatgtagagc
     5821 tgttcgatgg attcagccag tcctgcgtcc atgagaatct gatcaatttg ctggttgccg
     5881 aatttcaggc cgctgttgga atagtacgta gcgctgtctc caaaatagat gcgggtgcca
     5941 agatctccgg tgactacgga aatggtcagg gaaccttccg tgcccagcgg ggtgtcaacg
     6001 acgggcccgc tgtatgaggt gttgttccat aatccctgga gtttccggtc cgtgttcagg
     6061 cccacgcccc agcttacact gctgtttttg gcgttaaaca gagcggtata ggcgtccgga
     6121 gtgttgattt tggacaggtc aagaaccatc gtcacagaca taacgtcgcg gttgttggca
     6181 ccgtatccgt tgaaggttat cccggataac gtcagattgc tgtcgtcaga cgtgatggaa
     6241 acggaatctt tcagggtgcc gaaatccgcc gtttgggagg caaagtccga atatcccacg
     6301 atggagctat ccagcagaga ggtagccgcg gtagcgctta ggctcatgcc ggccgaaaga
     6361 atcagggtgg ataataattt attcatggtc agtatcttaa taaaatgatg caagattcaa
     6421 tgtatgtact tgtgcttgaa taacgaattt ggaatccgca agcaattaaa aatattaaga
     6481 gttagtatat tgtatttata attcattgaa aataatgatt ttttaatatc tctggtcctt
     6541 ttgtcaagat gacgggtcag tctttgttat tcattggttt catgattgat ttggcctctt
     6601 tttcattact tgacggattc caaatccgat tggggaattc caaattcgct acaagttgcc
     6661 atccaaaagg aataataaat atgaagaaaa cactgacact tttaatcgcg atgggaagct
     6721 ttgctgtttc ctcggaggca gcgaccgttt ttaattatta cactcccggt acggataatt
     6781 acaatagtac catccatggg ttttatctta gcctggggtc ttcttccctg gctccttccg
     6841 attcctcttc tccctcctcc ctgtccggag agatcagact ggacagtttt acgctgcgcg
     6901 gagccgccaa caatttgggc nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn
     6961 nnnnnnnnnn catcggctgg agcaccaata cgggaactac tgcagcaggg attaatctga
     7021 cgttcagttt ttcttccctg gatggttctc ccctgcttct tgacgcggca ttgacatacc
     7081 gcttcctggc cgtgagccag tccgtgatgg acttgatgca ggatacgtct aaaacgtatt
     7141 tatattctgc ggggggaaca gccgccccta ctgctaacac ggaaggagat accgtaacga
     7201 tcagcggcgg attgactgct cccggcatcc gcggccatta tgacgccgag ggagcgcctg
     7261 gtgattctgt tgttattacg ggagccaacg gaaccaatac tttcagctta ttatctccga
     7321 ttttcacgga aatccgaggg gaaatggtgc cggaaccagc cacggtttcc ctgggcctgc
     7381 tgggactggc cgcgctgatg atgcgccgcc gcagggcttg agcttcctga tggcgaaaaa
     7441 tcggcggatg agagctgttc ttgcggaaca gctcttgttt tttatatcca gagaggaaga
     7501 attactcatc cgcatgcggg attcatgccc tccggaaggt acgggatttc cgggggcagg
     7561 gggccgtatc cggttttttc cgcatggcgg caatttgctg gaaacgtttt tgagacgcaa
     7621 taccggaaag ctttttcttt accggaaaat gccggtcaaa ttcggcagcg cgcttttcgt
     7681 ccatatggta cacggcagct tccacatagc ggcctttcag gccggatagg gaaccccttt
     7741 gcagcgcaca gacctggagg gccgccgcat acctattatc cgccgttctg atgcccagcg
     7801 tttccgcggg aacgaatcca cagtgtgaag agtagtccgg gtcgccgtac aggaaaatgg
     7861 cacggaagcc catttcacgt gcccggttcc tggtgtagcc gatcatccgc cgtcctattc
     7921 cctggcgctg gtattccgga agaacggcaa tgggccccat gcccagcact tcatattctt
     7981 ttccatcgtc tgccctgatg acggacgttg catcaacgat gtttcccgac gatgcggctg
     8041 ccgtggacgg cgactgtatc cagctccgag atgaaggaag gactgacgcg catgatatgg
     8101 agcaggtaat gttcattgca gccggggacg aaatagttcc agagcgcttc tctcgtgaca
     8161 tgttccgttt cggcatggtc tgcggattgt tccgttctta atgcaatgat catgaagggt
     8221 tgttctttac ggctccccct tggagaaatt ccagaggcgg tgcatcgtca taacgtccgg
     8281 aatgttcatg gggcgcacca cgcggaaccc gatcatgcct ccgtccgtca ggtaccagat
     8341 gcttttaggg ttttgaggat cctgacggtt ccaggcgggg gtgctggcgc ggcgcgcagc
     8401 gcttctcagg ctgtccgggt cgtcttccca cgaaccgccg cgaacgatgt gaggggcacc
     8461 ggggatgatg accaaggggt ctttcgcggg caagccgctc cgtttgccgt aggcatccgg
     8521 aacgtaagag tccaaaaccc attccgccac atttccgtgc atgtcccgga gtccccactt
     8581 atttggtttt ttagagcctg ttttctggta gcggtcattg gagttgttcc agtaccaggc
     8641 gtactggtcc agagaggctt ccccgtttcc gtaagaatag gcgccggggg agccggcacg
     8701 gcaggcgtat tcccattccg cctccgtggg caggcggtag taatgcccgg tctgggcgct
     8761 cagccattcg cagaatttgc tggcggcgtg gtgggacatg gagatggcgg gcagaccgtg
     8821 ttcatagccg tggcccatgc ccaggttcat ggcggtgtag ggggcggtag gctgcgtaac
     8881 ggagtcccac agttcgtcat ccggctgttc ctccagaagc tgaccgtcct tggcgcgcgg
     8941 acgcccgttt tccatgaagg ccgtataaag ttcccagggg atttccgttt ccgagatcca
     9001 gaagggagag atgctcactt tatgctgcgg tccttcgtcc ggtttccggt gcggctcttc
     9061 cgcgggactc cccatgagga acgttcctcc cggtatggcg accatgcgca gggaagctcc
     9121 cgccgcggga accgtttccg tgtaggattc aaaacgtgcc ggatttccgg aagcttcaat
     9181 gagctgatgg atttggcgcg tcgtgccgac cagctcccgg gacggcaggt catccggaat
     9241 gggaagggca ggaccggcag cgcggtccag ttcccgtttt tgcagcgcgg atcggctttc
     9301 tccccattgg cgtgcgctgg taatgcgcgc ggcatcttcc gtggccgggc ggggggaatt
     9361 attttcttcc cggcacccgg ccagcaggac gcttcctccc agaaagcagg aaacaaggaa
     9421 aatgccgcgc atggaatggt gaaaaccgga atgccctaca tcgtcatgcc tccgtcgcag
     9481 gcaatgacct gcccggtgat gtaacgggca tcgtcagagg caaggaaggc cgtcagggcg
     9541 gcgatatctt ccacggaacc ttgttctttc aaaggtattt tcttaacgat ttcttccttg
     9601 agattgtcgg gaatggcatt ggacatttcc gtggagatga agccgggagc aatggcgttg
     9661 cacgtgactt tgcgcggagc gaattcctga gccagtgatt tggtgaaacc gatgaggccc
     9721 gccttggaag cggcgtaatt ggcctggccg atgttgccga cgagaccgat gacggagctc
     9781 atgttgatga tacgcccggc cggggatttc atgagaacgc gctggagggc cttgaccgta
     9841 ttgaacgcgc ttttcaggtt ggtgtccaga acggcatccc agtcttcctc tttcatgcgg
     9901 agcatcaggg agtcccgcgt gatgccggcg ttgttcacca ggatgtcaat ctgcgggaag
     9961 tctttcaaaa tggcggccat ggtttcctga acggccgcgt aatccgctac gtcgcagggg
    10021 taggccttgc aggaatccgg aaattccttg ttgatttctt ctgcggcccc cccgcagctg
    10081 gatggactgc ggctgatcag gatgaccctg gctccttccg aagcgaagcg gtgcgcgacg
    10141 gcattgccga ttccgcggcc cgcgccggta acgatggctg ttttacctgc taacttttgc
    10201 atgctgccca cagtaaaccc gtttttcacg gttccggcaa gcttgaaatg gacttggccg
    10261 cgcaggaacc catacgggga aagggcgtgc cgggaatgaa aaaagagggg ggagaaacgg
    10321 ggcggggggc tactgtccgg cctcttcatt ttcccggagt gcaccggggt gcgccccgtc
    10381 ttcatccggt tctgccaggt cgctgaattc atccgaattt tccaaaatgt cctttaaggc
    10441 ggcggaaccg taatagcggg cctcaaacag gcgtttgcct tcctgcctgc agcggttgtc
    10501 cagcatttcc attcgttttt tcattttttc tatcaaggcg tcttctttct ccttttccgc
    10561 atcgttcaat ttatcctgaa gctggaggaa atgccggatg tccttctgaa tgtcctgcag
    10621 cgttttgacg gcgttgtccg cgctttcctt gtcctgaacg cctgccaacg tctgctggat
    10681 attgatggca aaggaaaagg cctggttgat cagggattcc gcggaaggaa ttttttccgc
    10741 cggagccgct gctgcggggg aagccgttcc ggcggccgtt tcaccaaatg caagagaggc
    10801 tccggacaga agcgcagaat ataagagagg aacaagaaaa gccttcatcc tgttctttta
    10861 aggcaggatg aaatccacgg caaggaaaaa ggggaaactg aaaaaagagc cttattccgc
    10921 cgtgatgccg cctttttcat cgtccagaat gcctgacttt tccagatagt agtcatatcc
    10981 gcctgcgtag gcggtgatgg tcccccggtt cacatgcagg gttttttgtg ccagggaacg
    11041 gatgaagtgc acatcgtggg agatgaagac cagtgttcct tcataatgct tcagagcctg
    11101 caccagggct tctacggaca aaaggtccag gtgggtggtc ggctcgtcca tcagcaggag
    11161 gttgggcgga tccaccagga atttgaccaa gctgagccgc gatttttccc cgccggaaag
    11221 aacgctgacg cgtttttcca catccagcct ccggaacagg aaggaaccca ggatggaacg
    11281 cgcttcttcc tcccggattt cagcgctgca tttcatgatt tcctccagca cggtattttc
    11341 cggattcagg ttttccgttc gcgcctggga gaagtagccg atgcgcgtag tggtaccggg
    11401 agtgcgttgt ccggagtcaa tggggatgat gcccgccagg attttgagaa gagtggattt
    11461 gcccgcgccg ttcgggccta caagaacagt gcgctccccg cgttccacca gcaggtccag
    11521 gttttcataa accctgcggt cgccatagga ttggcagact ttttccagct caatgacttt
    11581 ctgggtgctg cgcggaggct gggggaagtt gaatttaaat actttcctgc gggctaccgg
    11641 tttttgaatg attttcatct tttccagctg cttgatgcgg ctctggactt gcccggcttt
    11701 ggaattgatg gagcggaaac ggtcaataaa ttcctgaatg tgcgctattt ccttctgctg
    11761 gttgcggtag gccgcctgaa gctgctcgaa gcgcacatcc ttttgttgga ggaagtccga
    11821 gtaattgccg cggtattcca ccagttcttc gttgtcgatg tcgtacacgc tttccaccag
    11881 ctcatccatg aaatcccggt cgtgggaaat catcaggatg gctccggggt agtttttcag
    11941 gtatcgctgg agccacagca gggacaggag gtccaggtgg ttggtaggtt cgtccagcat
    12001 caggaggtcc ggctccagga caaggagctt ggccaggtac gcgcgcatga tccagccgcc
    12061 ggacatttcc cgggcggggc ggtggaagtc gctttcccga aaggccagcc ctttgagaat
    12121 tttcttggct ttgggctcca gctggtaacc gttggcggcg ttgaaggtgt caatggcttc
    12181 cgcgtattcc ggcgtatccg ttttgttggc gttttccgcc gtccggatgg tgtggatggc
    12241 ctgttccatt tccggcgtga tgcccagggc gatttccaga acggtttcat ccttcggttc
    12301 gctggcttcc tggggaagat agcccacgat ggcgtattca tccatgctga tggagccttc
    12361 gtccggcgtg tcttctccca gaatcatgcg gaacagggtg gatttgcctg ctccgttggg
    12421 gccaaccaga gccacccgtt ccccccagtt aatggtcatt tccgtttccc tgaacaaggt
    12481 ccgtccggcg tgggattttg tgagattttt gatcgtcagc atggtgaaga gaggatgtat
    12541 tctaccggga tggaaagggg aaggcaagag ccgtcagggc ggaggcaggc atttttgaaa
    12601 gctttactgg atttttacgc gtagtctgct agccttggcg cgccatgccg accacgcaga
    12661 cattcaggct tttgcttgct gccgcccttt tgtgcggatg gagttcctgc tgtactcctc
    12721 cggcggagga ttatatacaa caaccttacg tgcagcagca aatgtccggg ctggctaatg
    12781 ccttcctggc gctgctgccg ccggatcagg cctctcttcc cgctgccgga gcggaggcca
    12841 ggtggctggc ggacacggcc gtggtccagt ccgcagcgat tgcccgggac aacaggactg
    12901 tgctgtttgg ctggctgaac aatattctgg tcaattccaa cctgcgcgac agggggctgt
    12961 gctggcaggt ccagcaggat ttgtaccggg acctgcgccg ccgccccgtg aagtatttcc
    13021 gcatagggct gacgattcga gaccgtggaa cgggcaggga gcacagttgc gtgtatgtca
    13081 atgccgtggg gaagggattg cagggctcca ttgttctgga tgcctggaag aactgcgggc
    13141 atctggtgac gctgacccag aaggaccggg aaggcggcaa atgggaggag gactggcggg
    13201 aaccatttgt ttccaaggcc tttccggagg gccattccta cggcatggaa catcacctgg
    13261 tctggcccgg gtgggccagg aaacgcccca tgctggttca gcggatattt cagtccgatc
    13321 agcagaatga ggcgaaggcg gccgctgaat aaaggggaag cctgatccgg caggaaccgg
    13381 cacacggtgc tgcgccgcgg cggtttgcgc cgtttttaag gaaaatcccg gcgaatcggc
    13441 aaatggcgga gggaatccgg actcagggca aataaaaacg cactcagtgc gtacaccgag
    13501 tgcggattaa ttggataatt tgctagtgtt gcagggcaaa accccgctgc aaacttactt
    13561 gcccttggcc tgcacaaccg gagcgggagc aggagcggtg gtttgctgtt gctgctgctg
    13621 ctgggagcaa gaagcgacca ggcaagcggc gccggcgatg gcgaggatag cgatgttctt
    13681 cataattcg
//
