LOCUS       gnlProkkaPHGJCEIG_58   12523 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|PHGJCEIG_58.
ACCESSION   gnlProkkaPHGJCEIG_58
VERSION     gnlProkkaPHGJCEIG_58
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 05:29:49
            Original ID  :: gnl|Prokka|PHGJCEIG_58
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 16937
            Orig. end    :: 29460
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12523
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10348]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10348
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12523
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12523
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(226..1038)
                     /locus_tag="ctg58_16"
                     /transl_table=11
                     /translation="MISITRDKRMLGYESLSSYSNISHFVTTRQGGYSEGNYASFNCTP
                     YSGDEAEKVRRNQTLLMEGMSQTPEELVIPVQTHETNCLLIGDAYLSASSQQRQEMLHG
                     VDALITREPGYCLCISTADCVPVLMYDKKHSAIAAIHAGWRGTVAYIVRDTLLRMEKEF
                     GTSGEDVVACIGPSISLASFEVGEEVYEAFQKNGFDMPRISIRKEETGKHHIDLWEANR
                     MQILAFGVPSGQVELARICTYIHHDEFFSARRLGIKSGRILSGIMIHK"
     CDS             complement(1035..2126)
                     /locus_tag="ctg58_17"
                     /transl_table=11
                     /translation="MRREKYCPNGGPDGGDGGRGGHIILRGNRNYWTLLHLKYDRHAMA
                     GHGESGSKNRSFGKDGADKVIEVPCGTVVYNAETGEYLCDVTDDGQEVILLKGGRGGQG
                     NSHFKTATRQAPRFAQPGEPMQEMTVIMELKLLADVGLVGFPNAGKSTLLSAISAAKPK
                     IADYPFTTLEPNLGIVSYRDGKSFVMADIPGIIEGASQGKGLGLRFLRHIERNSLLLFM
                     VPADSDDIRKEYEVLLNELRTFNPEMLDKQRVLAITKSDMLDQELMDEIEPTLPEGVPH
                     IFISSVSGLGISVLKDILWEELNKESNKIEDIVHRPKDVTRLQQELKEMGEDEELDYEY
                     EEDADDDDDDLDYEYEEEDWEEK"
     CDS             complement(2273..2842)
                     /locus_tag="ctg58_18"
                     /transl_table=11
                     /translation="MLNIVIFGAPGSGKGTQSERIVEKYGINHISTGDVLRAEIKNGTE
                     LGKTAKGYIDQGQLIPDELMIDILASVFDSFKDSKGVIFDGFPRTIAQAEALKKMLAER
                     GQDVSVMVDLDVPEEELMVRLIKRGKDSGRADDNEETIKKRLHVYHSQTAPLIDWYKNE
                     EKYQHINGLGTMEGIFAEICEAVDKL"
     CDS             complement(2876..3412)
                     /locus_tag="ctg58_19"
                     /transl_table=11
                     /translation="MNTIQIKDKQFTVSIKEQDIQKEVIRVANEINRDLAGKNPLFLSV
                     LNGSFMFTADLLKHITIPCEISFVKLASYQGVTSTGVIKEVIGLNEDIAGRTVVIVEDI
                     VDTGLTMQRLLDTLGTRNPAEIHIASLLVKPEKLKVALNIEYVAMEIPNDFIVGYGLDY
                     DGFGRNYPDIYTVVD"
     CDS             complement(3454..4998)
                     /gene_functions="transport (smcogs) SMCOG1202:major
                     facilitator transporter (Score: 56.1; E-value: 3.9e-17)"
                     /gene_kind="transport"
                     /locus_tag="ctg58_20"
                     /transl_table=11
                     /translation="MSSLKGHPKGLYLIFATSTAERFSYYGMRAIFILFLTQALLFDKE
                     AAASIYGSYTGLVYLTPLIGGYIADKYWGIRRSVFWGAVMMAVGQFLMFMSASSLNNTD
                     LAHWLMYGGLGFMILGNGCFKPTVSSLVGQLYEPGDKRLDAAYTIFYMGVNVGSFAAPL
                     ICGFLGDTGNPQDFKWGFLASGIMTLFTVVLFETQKNKYLFSPSGEPIGIVPDARREKK
                     EDKAEHISHPKMDKRTKVRNIIIITALTVALIAFFSYAFSDDWISVGIFTACIVFPVLI
                     LLDGSLTKVERSRIFVIYIVAFFVIFFWAAYEQAGASLTLFASEQTDRSIFGWEMPASW
                     FQSFNPLFVVILAYIMPGIWSFLNKRNMEPASPTKQAIGLLLLSLGYLFICFGVKDAIP
                     GVKVSMIWLTGLYFIHTMGEIALSPIGLSMVNKLSPLRFASLMMGIWYLSTATANKFAG
                     MLSGLYPEDGKVKSILGYQIATMYDFFMLFVIMSGVASLILFLLSKKLQKMMHGVE"
     CDS             5173..5319
                     /locus_tag="ctg58_21"
                     /transl_table=11
                     /translation="MWVSPHLSKGKFNILNTGIEHSFFFSKQDFVFPCQPTDSNRYILE
                     RQT"
     CDS             5904..6521
                     /locus_tag="ctg58_22"
                     /transl_table=11
                     /translation="MTNENEKVVQVNYHNGSLTLKAKEIGRASIKIEDSSNNMYILSVV
                     VKYRTLTHKAFTAKVIVKGDELTSEEHTELMNKVGNSYPINKYVFTFMNAEDSKGTVDL
                     YYSDNNMKTGNFEKEHIVLDEENAIPIKGEYKLSEYYRITIKEDNGKVIDTFYITKNFL
                     PLLNTRMNAHPLIQYCFVRDLTAQYKQDYLALENAYLIQIAE"
     CDS             7053..8564
                     /locus_tag="ctg58_23"
                     /transl_table=11
                     /translation="MKIFPSSSIKKLDAYTIEHEPIASIDLMERAAQALTKAITNRWNP
                     ETPVTIFAGPGNNGGDALAIARMMAEKGYKIEVYLFNTKGELSPDCQTNKELVEMMEEV
                     TFHEISTQFVPPTLTPEHLVIDGLFGSGLNKPLSGGFAAVVKYINASPAMVVSIDIPSG
                     LMGEENTFNVKSNIIRADVTFSLQLPKLAFLFAENTEFVGEWELLDIQLSEEGIEETET
                     NYEMLEIEEIRSLIKPRQQFAHKGNFGHALLIAGSKGMAGASVLAARACLRSGVGLLTV
                     HAPLCNNDILQTSAPEAMVETDVSETCFAVPTDTDDYQAVGIGPGLGRSEETEAALIEQ
                     LEHCQTPTVLDADALNILANHRHTLTHLPKGSILTPHPKELERLVGKCQDSYERLMKAC
                     ELAHTAKVHIILKGAYSAIITPEGKCYFNQTGNPGMATGGSGDVLTGVILALLAQGYPA
                     EDAAKIGTYIHGLAGDIAQKKQGMIGLIASDIVTCLPTAWRLVSE"
     CDS             8638..9702
                     /locus_tag="ctg58_24"
                     /transl_table=11
                     /translation="MKKFIIATGLLVATSAYAQTEVLTGVTRGKDYGVVYALPKTQIEI
                     EIKANKVNYKPGEFSKYADRYLRLTNVSAEPEEYWELNSVKVKPVGVPNSEATYFVKLK
                     DKTVAPLMELTEEGLIKSINVPYSSNNAKNAANNAVAPQRKANPRDFLTEEILMASSTA
                     KMAELVAKEIYNIRESKNALLRGQADNMPSDGAQLKIMLDNLNLQEEAMTEMFSGVRNK
                     EEKTFTVRLTPDKEFDNEVAFRFSKKLGIVANNDLAGTPFYISLKDLKTVKIPQEDGKK
                     KKEMEGIAYNVPGQAMVTLSDGKKKLYEGEIPVTQFGIIEYLAPVLFNKNSTIKVYFDP
                     VTGGLLKVDREESK"
     CDS             9724..10011
                     /locus_tag="ctg58_25"
                     /transl_table=11
                     /translation="MGGEGHMLDMIRRLKDGKEASRLRRERRNDKLGRLRRNNDPYLLP
                     DTTPEEMERIIKDSEKKKEKDNSYFVWGTLIIMGVLIGCAVLLWAIIFNG"
     CDS             complement(10001..10348)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg58_26"
                     /sec_met_domain="PF05402 (E-value: 2.8e-17, bitscore: 53.8,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1e-09, bitscore: 29.0,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATKEKINLLEVIPCRNEHIKAEQEGETIVLSFPRFKRSWMSRYL
                     LPKGMSKDIHVRLEEHGTAVWNLIDGQRTVREIIEKLADHFQYEAGYESRVSTYLSQLQ
                     KDGFIKWIIIH"
     CDS             complement(10393..11781)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 90.5; E-value: 1.4e-27)"
                     /gene_kind="transport"
                     /locus_tag="ctg58_27"
                     /transl_table=11
                     /translation="MTEQLKQKLNDSAVLRWSVLALVAFTMLCGYFLTDVMSPLKPMLE
                     KELLWDSLDYGFFTSAYGWFNVFLLMLIFGGIILDKMGVRFTGMGACLLMVFGCGLKYY
                     AITTTFPEGAMLFGFKMQVTLAALGYAIFGVGVEIAGITVSKIIVKWFKGKEMALAMGL
                     EMATARIGTTLAMVLTVPLADFFGSTDESGVFHTNIPAPILFCLVMLCVGTIAFFIYTF
                     YDKKLDASLDAEGLEPEEPFRMKDIVYIITNKGFWLIALLCVLFYSAVFPFIKYAADLM
                     VQKYNVDPKLAGTIPGLLPIGAIILTPLFGSLYDRIGKGATLMVIGSVMLIFVHTMFAL
                     PILNIWWFATVIMIILGFAFSLVPSAMWPSVPKIIPEKQLGTAYALIFWVQNWGLMGVP
                     LLIGWVLNSYCKGPVVDGAQTYDYTLPMAIFAMFGVLALIVALMLKVENKKKGYGLEEA
                     NIQK"
     CDS             complement(12072..12287)
                     /locus_tag="ctg58_28"
                     /transl_table=11
                     /translation="MVVMSVATAYVVPSSSAAKDVLLEQAQKEQQTNPYNMPTGTAAPQ
                     TDATAPAESAPATEAPATETPAPVAE"
     CDS             12412..12522
                     /locus_tag="ctg58_29"
                     /transl_table=11
                     /translation="MKHISKAAITIKIMNNKYIFSYFELALIINFSKNLIW"
ORIGIN
        1 agcaatcaca ggttgcaact taatgtctgc catttgggtg gtggtagtca agtcttctgt
       61 gaaagtattt atttctttcc aaagtccatc gcagtaagca gtattcttca ctgctgcata
      121 tacggctgct ccggcaaaaa cagggcaggt gttctttatt tcctgagata cttttatttc
      181 aaacatactt ttattcaagt ttatatcaac ttacgttcaa gtctattatt tatgaatcat
      241 gatccccgac agaatccgtc cggacttaat gcccaaacgc cttgccgaga aaaactcgtc
      301 gtgatgaata tacgtacata tccgggcaag ctccacttgg ccggacggca caccgaaagc
      361 aaggatttgc atccggttcg cttcccacaa gtcgatatga tgttttccgg tttcctcttt
      421 cctgatagaa atacgaggca tatcaaaacc attcttctga aatgcttcgt acacttcctc
      481 acccacttca aaagaagcca atgagatact cggaccgata caggcaacta catcttctcc
      541 acttgtgcca aactcctttt ccatccgcaa caaagtatca cgcacgatgt atgctaccgt
      601 ccctctccat ccggcatgaa tggcagctat ggcactatgt ttcttatcat acatcaacac
      661 aggaacacaa tccgcagtag aaatacaaag acaatatccc ggctcgcggg taatcaaagc
      721 atccactccg tgcagcatct cctgtcgttg ttgagacgaa gccgataaat aagcatcccc
      781 gatcagcagg caattcgtct catgagtctg cacaggaatc accagttctt cgggtgtctg
      841 cgacattcct tccatcagaa gcgtttgatt ccgccggacc ttttccgcct cgtctccact
      901 gtagggcgta cagttgaatg acgcataatt tccttcgctg taccctccct gccgggtagt
      961 tacaaaatga gaaatgttgg agtatgagct taacgactca taccccaaca ttcttttatc
     1021 tcttgtgatt gaaatcattt ttcctcccaa tcctcttctt cgtattcgta gtcgagatca
     1081 tcatcgtcgt cgtcagcgtc ttcctcatat tcatagtcga gttcttcatc ctcgcccatc
     1141 tctttgagtt cctgttgcag acgggtcacg tctttcggac ggtgaacaat gtcttctatc
     1201 ttattacttt ccttgttcag ttcctcccac agaatgtctt tcaacactga gattcccaaa
     1261 ccggaaacag aagaaatgaa tatatgcgga acaccctcgg gcaatgtcgg ttcaatctcg
     1321 tccatcagct cctgatcgag catatcgctc ttcgtgatag ccagcacacg ttgtttgtcc
     1381 agcatttcgg gattgaacgt acgcaactca ttcagcaata cttcatactc cttgcggata
     1441 tcatcgctat ctgccggaac catgaacaac agcaacgagt tacgctcgat atgacgcaga
     1501 aaccgcagtc ccaatccttt tccctgactg gctccctcga tgatgcccgg tatgtccgcc
     1561 atcacgaatg actttccatc gcgataggaa acaattccca gattcggttc gagtgtcgta
     1621 aacgggtaat cggcaatctt cggtttcgca gccgaaatgg cagaaagcaa cgtagacttt
     1681 cccgcattcg ggaaacctac cagtcctaca tctgccaaca gtttcagctc catgatcacc
     1741 gtcatttcct gcatcggttc gcccggctgc gcaaagcgcg gagcctgacg ggtagccgtc
     1801 ttgaaatgac tgttaccctg accgccacga ccgcctttca gcaagatcac ttcctgtccg
     1861 tcgtccgtca catcgcaaag gtattctccg gtttcggcgt tatacactac cgttccgcag
     1921 ggtacttcga tcactttatc cgcaccgtct tttccgaaac tacggttctt gctgcccgat
     1981 tcgccatgac ctgccatcgc atgacggtca tacttcaagt gaagcaatgt ccagtaatta
     2041 cggttaccgc gcaagataat atggcctcct cttccaccat cgcccccatc gggacctccg
     2101 ttaggacaat atttctcgcg cctcatgtgc gtagagcctc ttccgccctt acccgagcga
     2161 cagtatatct ttacgtaatc aacaaaattc gattcagcca tattctttta gtaagttaaa
     2221 atggtcagta gccaaagcaa gataccccgg ccactggcct atctgtttat tattacaatt
     2281 tgtctactgc ttcgcagatt tctgcaaaga taccttccat agtacccaaa ccgttgatgt
     2341 gctggtattt ctcttcgttc ttgtaccagt caatcagcgg ggcagtctgt gaatgatata
     2401 catgcagacg ttttttaata gtctcttcgt tgtcatccgc acggccagag tctttgccac
     2461 gtttgataag acgcaccatc agttcttctt caggaacatc gaggtctacc ataacagaaa
     2521 catcctgtcc tctttcagcc aacattttct ttaatgcttc cgcctgtgca attgttctcg
     2581 ggaaaccgtc gaaaattaca cctttgctat ctttgaagct atcgaatacg cttgccagaa
     2641 tatcaatcat cagttcgtca ggaatcaatt gaccttggtc gatgtatcct ttagcagttt
     2701 tacccagttc tgtgccgttc ttgatttctg cacgcaatac atctcctgtc gagatgtggt
     2761 tgattccata cttttctaca atacgttcgc tctgtgttcc ttttcctgaa cccggagcac
     2821 cgaaaattac aatattcaac atctttttta cctaaaaatt aatttgtatt tgaatttaat
     2881 ctactactgt ataaatgtcg ggataattac gtccgaagcc gtcatagtcc agtccgtaac
     2941 ctacgataaa gtcattcgga atctccatcg ctacatattc aatattcaag gctactttta
     3001 gtttttccgg tttcaccaac agggaagcga tatggatttc ggcgggattg cgtgttccca
     3061 atgtatccaa caggcgttgc atagtcagtc ccgtatccac aatatcttct acaatgacaa
     3121 ccgtacgtcc ggcaatgtcc tcattcaggc cgattacttc cttaatcact ccggtggaag
     3181 tgactccctg ataagaagct aatttcacaa atgatatttc acaagggatt gtgatgtgct
     3241 tcagcaaatc ggcagtgaac ataaacgaac cgttcaacac actaaggaaa agcggattct
     3301 tacctgctaa atcgcggtta atttcgttcg ctacacgaat cacttctttc tgaatatctt
     3361 gttccttgat agaaacggta aactgcttgt cttttatctg aatggtattc ataaccggta
     3421 attttaaaaa agttgtcgca aaaatacaat tttttattct accccgtgca tcatcttctg
     3481 taatttcttc gagagaagga acagaatcag tgaggcaaca ccggacataa tgacgaacag
     3541 catgaagaag tcgtacatgg tagcgatctg ataaccaagg attgatttca cttttccgtc
     3601 ttcgggatag aggccgctca gcatacctgc aaatttattt gcggtggcgg tagaaagata
     3661 ccagatcccc atcatcaagg aggcgaaacg taacggactc aacttattaa ccatagaaag
     3721 cccgataggt gacagagcga tttctcccat tgtatgaata aagtaaagcc ctgtcagcca
     3781 gatcatgctc acctttactc ccggaatagc atctttcact ccaaaacaga tgaagagata
     3841 accaagagaa agcagtaaca gaccgattgc ctgtttggta ggggaagccg gttccatgtt
     3901 tcgcttattc agaaagctcc atataccggg cataatatag gcaaggatca ctacaaaaag
     3961 cggattgaat gactggaacc acgaagccgg catctcccag ccgaaaatgc tgcggtcagt
     4021 ctgttcggaa gcgaataatg tcagagaagc tcctgcctgc tcgtaagctg cccagaagaa
     4081 aatgacgaag aaagctacga tatagattac gaaaatacgg ctacgttcta ctttggtcaa
     4141 tgaaccatcc agcagaatga gcactggaaa gacaatacaa gccgtaaaga tacccacact
     4201 aatccagtca tcgctaaagg catagctaaa aaaagctatt aaggcaactg taagggcagt
     4261 aatgatgatg atattacgta ctttggtacg tttgtccatc ttcggatgtg aaatatgttc
     4321 ggctttatcc tccttttttt cacgtctggc gtcggggacg ataccaatcg gttcaccgga
     4381 aggagagaaa aggtatttat tcttctgagt ttcaaagagg acaacagtga acagcgtcat
     4441 gattccggat gcgaggaatc cccatttaaa gtcctgcgga ttccctgtgt ctcccaagaa
     4501 accgcaaatc aaaggagcag caaaagaacc tacattaaca cccatataga aaatggtgta
     4561 tgcagcatcc aaccgtttgt ccccgggttc atataattgc ccgacgagcg aagaaacggt
     4621 aggcttaaag caaccgttac ctaaaatcat gaatccgagc ccgccataca tcagccagtg
     4681 ggcaaggtct gtattgttca gtgaagaggc actcataaac atcaggaact gaccgactgc
     4741 catcatcacc gctccccaaa ataccgaacg acggatgccc caatatttat cggcaatgta
     4801 tccgccgatc aacggagtca gatagaccag tccggtgtag ctaccgtaga tagaggccgc
     4861 cgcttcttta tcaaaaagca atgcctgcgt cagaaagagg ataaagatag cacgcatacc
     4921 gtagtaactg aaacgttctg ccgtgctcgt tgcgaaaatt aggtaaaggc ctttcgggtg
     4981 ccctttcaat gaactcatga attatgtgtt tagtagttta tggggtgcaa aggtactaaa
     5041 aagtagatta aatgcctcaa aaaagaagat tcttatggaa tagaaaaata caggatggcg
     5101 tgcaaaaagt ctcagttacc caccttatta tgttttcaac agtgtaaata atcaagtgga
     5161 tattctcctt aaatgtgggt cagtccccat ttatccaaag gtaaattcaa cattctcaat
     5221 actggcatag agcattcctt ctttttttct aagcaggatt ttgttttccc ttgccagcca
     5281 accgatagca atcgctacat cctcgaacgt caaacctaac tcatggcaca aagtgaacat
     5341 agactgttcg cccttttcat ttaagatgcg ccatactttc ccggcatttg agccaattct
     5401 tttcttttcc atcatgcaaa ctttagaaga ttaaacaatt tatatttata atctaaacat
     5461 tgtgagcaca ggagaataac gtaaagcaca ttactgcact acaaagatat catttttttc
     5521 gaaaaaagca aataatcaaa gcattagctg ctattattag ttacattcta atcatttatg
     5581 ccgatctctg ctaaaaaata gcacaaataa agaaacagtt caattctttt tcataagttt
     5641 gcagacgaga actaaactaa tatcgcacat ttaaaacttt aattagcatg actaccaaaa
     5701 aactaacagg aatactttcg ttattccttt gtattatttg cctcgtgagc tgtaatgaca
     5761 atgatgacaa cttttctcca atcactctgg aatatgaaga tcctcaaatt aagttcgaca
     5821 acgagagccg ttcttacaca ctgactccgt tcagcaaaga aacgacacca ctcttcatca
     5881 agggtggaga cggaacttac aaagtgacca atgagaatga gaaagtggta caagtaaact
     5941 accacaacgg aagtttaaca ttgaaggcaa aggaaatagg acgcgcatcc atcaagatag
     6001 aagacagttc aaataatatg tatatactgt ctgtcgttgt aaaatatcgt actcttactc
     6061 ataaggcgtt tacagcaaaa gtcattgtga agggagacga gcttacatct gaagaacaca
     6121 ctgagttaat gaacaaagtg ggcaattcat atccgattaa taaatatgta tttactttta
     6181 tgaatgcgga agacagcaaa ggaacagtag atttgtatta ttcagataat aacatgaaaa
     6241 caggcaactt tgaaaaagaa catatagtgc tggatgaaga aaatgccatt cccatcaaag
     6301 gtgaatacaa attgagtgag tattaccgta taacaatcaa agaagataat ggcaaagtta
     6361 ttgatacttt ctatattacc aagaactttc taccactcct caatacaaga atgaatgctc
     6421 atccgttaat tcagtactgt tttgtcagag atttaaccgc acagtacaaa caagattacc
     6481 ttgcactgga aaatgcatat ctgattcaaa tagcagaatg agagctacac tgattttctt
     6541 ctttagcaga gtgaatagag tatttattat atgagcaaac tccccattag atttagcaaa
     6601 aaacaataag ctattagcta atcaagaata tgcccatagc atatttatca caatcacctc
     6661 ttccaccctt ttcctgaacc tttgatgaat aaggcgattg cgggtgaaag aggtgaacca
     6721 gaggaatata cagtagtaga aacacgcatg ggaaggttaa caaacagcca tgaatgttct
     6781 ccggagagag taaaagtaaa tgagataaca atgcttgtta tactgcgtta caagcattga
     6841 aagccatcat aacaagcatt gatatctacc ataacaatca ttaatatctg acttctcaac
     6901 tattaataac tgacacatca actattaata cctgacaact caagtattaa tacctgaagt
     6961 tccttcccaa aaagccgaaa accaaccgga ataaaggatt aattcagagt ttttgtgtaa
     7021 gtttgtgcgt cgaaaactaa aagaatatcg caatgaaaat atttccaagc agcagcatta
     7081 agaagttaga tgcctatacc attgaacatg aaccgattgc atccatagat ttaatggaac
     7141 gtgccgcaca ggcgctgact aaagccatca ccaacagatg gaatccggaa acacctgtca
     7201 ccatctttgc cggaccgggc aataatggcg gagacgccct cgccatcgcc cgcatgatgg
     7261 cggaaaaagg atacaagatc gaagtatatc tcttcaacac gaaaggcgaa ctttcgcccg
     7321 actgtcagac caacaaagaa ctggtagaga tgatggaaga agtaactttc catgaaatca
     7381 gcacccagtt cgtacctccc acactgacac cggaacatct cgtgatcgac ggattattcg
     7441 gttccggact caacaaacca ttgagcggag gattcgctgc cgttgtgaaa tatatcaatg
     7501 cctctcccgc catggtagtc tccatcgaca tcccttccgg actgatggga gaagaaaata
     7561 cattcaatgt aaaaagcaat attatccgtg cggacgtcac tttcagcctg caacttccta
     7621 aactggcctt cctctttgcc gaaaatacag aatttgttgg cgaatgggag ttattggaca
     7681 tccagctgag cgaagaagga atcgaagaga ctgaaacaaa ctacgaaatg ctggaaatcg
     7741 aagaaatccg ttcgctaatc aaaccacgcc aacaattcgc ccataaagga aacttcggac
     7801 atgccctgct gatagccggc tcaaaaggaa tggcaggtgc atcggtactg gccgcccgtg
     7861 cctgtctgcg atcgggagta ggtctgctga ccgtacacgc gccgttatgc aacaacgata
     7921 ttttgcaaac gtccgccccc gaagccatgg tagaaacgga tgtcagcgaa acatgctttg
     7981 ccgtacctac cgatacggac gattaccaag ctgtcggcat cggtccggga ctcggtcgca
     8041 gcgaggaaac ggaagccgcc ctgatagaac aactggaaca ttgtcagact ccgacggtac
     8101 tggatgccga cgcactcaat attctggcca atcaccggca tacgctcacc catctgccga
     8161 aaggttccat cctcacccct cacccgaaag agctggaacg cctggtcggc aaatgtcagg
     8221 actcatacga acgactgatg aaagcctgcg aactggcgca cactgccaaa gtacatatca
     8281 ttctgaaggg agcttattcc gccattatca cccccgaagg caaatgttac ttcaaccaga
     8341 ccggtaatcc cggtatggca acaggaggca gcggagatgt actgacagga gtaatccttg
     8401 cactccttgc gcaaggctat cccgccgaag acgccgcaaa gatcggtact tacattcacg
     8461 gattggccgg agacatcgcc cagaaaaaac agggcatgat cggattaatc gcaagtgata
     8521 tcgtcacctg tctgccgacg gcatggcgac ttgtaagcga ataaaagtta agaacttacg
     8581 gtttattcaa taacttcatt aactttgttt ttcaaaatca gctaaaaaga accgaatatg
     8641 aaaaagttta tcatagcaac aggactacta gtggcaactt ccgcctatgc gcagaccgaa
     8701 gtgctgacag gagtgacgcg aggaaaagac tacggagtag tgtacgccct ccccaaaacc
     8761 cagatagaaa tagaaataaa agcaaacaaa gtcaactata agccgggtga attcagcaaa
     8821 tacgccgacc gctacctgag actgaccaac gtctctgccg aacccgaaga atactgggaa
     8881 ctgaacagtg tcaaagtgaa acctgtaggt gtaccaaaca gcgaagctac ttatttcgtc
     8941 aaactgaaag acaaaaccgt agctcctctt atggaactga ctgaagaggg tcttatcaaa
     9001 tcaatcaacg tcccctacag cagcaacaat gcaaagaatg cagcaaacaa tgccgttgct
     9061 ccccaacgaa aagccaatcc ccgcgacttt ctcacagaag aaattctgat ggcaagttca
     9121 accgccaaga tggccgaatt ggtagcaaag gaaatctata atatccgcga aagtaaaaac
     9181 gcattattgc gcggacaagc agataatatg ccttcggacg gcgcacaact caaaatcatg
     9241 ctcgacaacc tgaatcttca ggaagaagcc atgaccgaga tgttttcggg agtccgcaat
     9301 aaagaagaaa agacatttac tgtccgcctc actccggata aggaattcga caatgaggta
     9361 gctttccgct tttcaaagaa gctgggtata gttgccaaca acgatttggc aggcactcca
     9421 ttctacatca gtctgaaaga cctgaaaacg gtgaagattc cgcaagagga cggaaaaaag
     9481 aagaaagaga tggaaggcat tgcttataac gtaccgggac aggcaatggt gacgctgtcg
     9541 gacggcaaaa agaaattgta tgaaggagaa atacctgtta ctcagttcgg tatcatagaa
     9601 taccttgctc cggtattatt caacaagaac tcgaccatca aagtttactt tgatccggtg
     9661 accggtggac tactgaaagt agatagagaa gaaagcaaat aaaacctcta aaaaaacaaa
     9721 acgatgggtg gcgaaggaca tatgctcgac atgatacgtc ggctgaaaga cggcaaagaa
     9781 gcctcccgct tacgccgtga acggagaaat gacaagttag ggcgacttag aagaaacaac
     9841 gacccttatc ttctgccgga tacgactccg gaagagatgg aacgcatcat caaggattcg
     9901 gaaaagaaaa aagaaaaaga taacagctat ttcgtatggg gaacgcttat cattatgggc
     9961 gtactgatag gatgtgctgt cctcctgtgg gcaatcattt ttaatggata attatccatt
    10021 taataaatcc gtctttctgt aattgggaaa gataggtaga tacacgagac tcgtagcctg
    10081 cttcatattg aaagtggtct gcgagttttt ctataatctc acgaaccgtc cgctgcccgt
    10141 ctatcaggtt ccatacggcc gtaccgtgtt cttccagacg cacatgaata tctttggaca
    10201 ttcctttcgg caataaataa cgactcatcc acgaacgttt aaaacgaggg aaggagagca
    10261 caatagtctc cccttcctgt tcagctttaa tatgttcgtt acgacaaggg atcacctcca
    10321 ggaggtttat tttctctttc gtagccatat cttttctctt ttatatcttt tcagatagaa
    10381 tatatactgt gattatttct gaatatttgc ttcttccagt ccgtagcctt tcttcttgtt
    10441 ttccactttc agcatcaagg caacaatcag ggcaagtaca ccgaacatag caaaaatagc
    10501 catcggcaag gtataatcat aagtctgtgc accatctaca accggacctt tgcaataaga
    10561 gttcaacacc catccgatca gcaaaggcac gcccatcaat ccccagttct gtacccaaaa
    10621 gatcagcgca taagccgttc ccaactgttt ctccggaata atcttcggaa ccgaaggcca
    10681 cattgccgaa ggaaccaatg agaaagcaaa tcccagaata atcatgatca ccgttgcaaa
    10741 ccaccatata ttcagaatag gaagagcgaa catcgtgtgt acgaaaatca gcatcaccga
    10801 cccgatcacc atcagcgtgg ctcccttacc gatacggtca tacaatgaac cgaacaacgg
    10861 tgtcaggatg atcgcgccaa tcggcagcaa tccgggaatc gttcccgcaa gtttcggatc
    10921 aacattgtac ttctgtacca tcaaatcggc cgcatacttg atgaagggga atacagccga
    10981 atagaacaat acgcacagta atgcgatcag ccagaatcct ttgttggtaa tgatatagac
    11041 aatgtctttc atgcggaaag gttcttccgg ttccagtcct tccgcatcca gtgaagcatc
    11101 cagtttctta tcgtagaaag tatagatgaa gaatgcgatg gtacctacgc acaacatgac
    11161 gagacagaac agaataggag cgggaatatt ggtatggaat acgccgctct catccgtaga
    11221 cccgaagaag tctgccaaag gaacggtaag caccatggcc aaagttgttc caatacgcgc
    11281 ggtcgccatt tccagtccca tagcgagagc catctctttg cctttaaacc acttcacgat
    11341 aatcttcgaa acggtgatac ccgcaatttc gactcctaca ccgaaaatag cataacccaa
    11401 tgcagccaat gtgacttgca tcttgaatcc gaaaagcatc gcaccttccg ggaaagtagt
    11461 agtaatagca taatatttca atccacaacc gaacaccatc aataaacagg cacccattcc
    11521 ggtgaagcgt actcccatct tatccagaat gataccacca aagatgagca tcagcaggaa
    11581 tacattaaac cagccataag cactggtgaa aaaaccgtaa tctaaactgt cccagagaag
    11641 ttctttttca agcatgggtt tcagaggaga cataacgtct gtgaggaagt agccgcacaa
    11701 catggtaaaa gcgactaatg ctagaacact ccaacgcagc actgcggagt cattcagctt
    11761 ttgtttcaat tgttctgtca ttgtaatatt taaaaggagt taataatctc gtaacgggca
    11821 acaaagttaa ctaattatca tttgttttac taaaaaagga gaacatttta taagaaaaag
    11881 gacatctgac cggatattcc tgtatgaaga agagcagacc gggcccaata ataaagacag
    11941 gcgcgaacta cacgtattac acgattctat tagaatctct tgtaattcgc gtaattcgcg
    12001 cctataatga agagaacggg tcaaaaagcc cgttcactca ataagtttaa accgaatatc
    12061 ctgtcactga attattctgc tacaggagca ggagtttcag tagccggagc ttccgttgct
    12121 ggtgcagact ctgcaggagc agtagcatct gtctgaggag cagcagtacc ggtaggcata
    12181 ttatacgggt tggtttgttg ttctttctgt gcttgttcca acaatacatc tttagctgca
    12241 gaagaagaag gaacaacgta agcagtagca acgctcatca caaccatgaa gatagccaga
    12301 ccccaagttg ctttttccag aaaatctgta gtcttgcgca cgcccatgat agcgtttgat
    12361 gaagaaaaac cagaagcaag tccgcctcct tttgaattct gaatcagcac gatgaagcac
    12421 atcagcaagg ctgcaatcac cattaagata atgaataata agtacatttt tagttatttt
    12481 gaattagcgt taataatcaa tttctccaaa aatctgattt ggt
//
