LOCUS       c00116_gnlPro..        11312 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|MOEBFLDB_116.
ACCESSION   c00116_gnlPro..
VERSION     c00116_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 11:59:07
            Original ID  :: gnl|Prokka|MOEBFLDB_116
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11312
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..2019)
                     /locus_tag="ctg116_1"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGTITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTF"
     protocluster    1..11312
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2520:8506]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2521..8506
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11312
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11312
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(2521..3567)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_2"
                     /sec_met_domain="IlvN (E-value: 9.8e-49, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.2e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             complement(3609..4340)
                     /locus_tag="ctg116_3"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLTDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSLD
                     KYNMAICNDGKAISRAAVTWI"
     CDS             complement(4377..4931)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_4"
                     /sec_met_domain="ALS_ss_C (E-value: 9e-19, bitscore: 56.7,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             complement(4944..6644)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.7e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LKHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGG
                     AEEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELG
                     TIMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVD
                     KREDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             complement(6671..8506)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg116_6"
                     /sec_met_domain="ILVD_EDD (E-value: 2.1e-218, bitscore:
                     715.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKNPLRSSYSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSF
                     TQFVPGHVHLHEIGQQVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIAD
                     SVEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTIFVSGGPMEAGNLDGRALDLI
                     DAMIEAADDSISDEQVEKVERSACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTVVAT
                     HANRTRLFKKAAKMIVDNAFKYYRDGDDSVLPRSIATRQAFLNAMSLDIAMGGSTNTVL
                     HLLAVAHEAEVDFTMKDIDMLSRKTPVICKVAPSCSYHVEDVNRAGGIIGIMNELVKAG
                     LVDGSVKRADGLTLNEAIDQYCITSVNVTEEAINIYKSAPAHRFNLVLGSQESYYKELD
                     TDRATGCIRDVEHAYVKDGGLAVLYGNIAQDGCVVKTAGVDESIFRFAGPAKVFDSQDA
                     ACEGILKDQVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGAIGLVKDGDIIEINIPERTIHVKVTDEELAKRREAEEARGTK
                     AFTPPFRQRTVSKALKAYAKMVASADKGGVRIVED"
     CDS             9549..10766
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg116_7"
                     /sec_met_domain="Aminotran_1_2 (E-value: 1.1e-43, bitscore:
                     138.8, seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTPIAIKKLIVNKNMKHYNFDEVIERHGTSCVKFDRLKEMFGDEN
                     LIPLWVADMDFRTPDFIVEALKKRCEHEIFGYTFGSDEYYESIINWVHYKHNWKIQREW
                     ISYIPGIVKGIAFAIQCFTQKGDKVIIQPPVYHPFRIVPEKMKREVVYNPLKMVDGVYE
                     MDFDHLESIIDDKCKVLILCNPHNPGGIVWKKETLVRLAEICAKHNILVISDEIHAEMA
                     YPQYTHYPFASVSDTAASCSLTFMAPSKTFNIAGIVTSYAIVPNDRIREEFYSFLEAGE
                     FGDGTIFAYTATTAAYTYGAEWLQQMRMYIMENVRFVEEFMKLHLPKIKVYQPQASFLV
                     WLDCRELELSQDELVHLFKDKAGLALNDGSIFGPGGEGHMRLNIGCPRSVLDKAMNALK
                     KAVDKK"
     CDS             10815..11312
                     /locus_tag="ctg116_8"
                     /transl_table=11
                     /translation="MKITANKYVAVTYDLNVGEGEERELMEKATVEAPLKFIYGTGMML
                     PAFEKALNGLEVGGTFNFSIEPAEAYGEYNEEHVLDLPKNIFEVDGKFDAEMIKEGNTV
                     PMMDSNGNRMNGSVLEVKDDIVVMDFNHPLAGETLHFSGEVIDVHEPTAEEIAAFSAPA
                     GGC"
ORIGIN
        1 gaatgtaccc cagcgatgat cggagctgaa acgggaagaa ccatcctcac gaagtgaagc
       61 ggacaagtaa tacttattca agaagttata atcgacctta ccaaagaacg aaagcagaga
      121 gtatttatca cgtccgccgg aaacaccgaa gttcttggtg gtattcgata attcatattt
      181 acccagttcc atgatacctt caccccaacc ttgttcgtag tgggagtccc aggtatacca
      241 ctcatgtccg accagacctg aaatcgtatg gtcaccaatc atccattcac cagacaatac
      301 attattccag gtggtggaac gtttattgaa attataacgg ctggcataac caccgtctgc
      361 cagtatagaa ataccataag gtgcagtctg tccgctgcca tgtacggcgg aagtatattg
      421 catggtacga taccagtaat cgtcaatatt caaagccgaa cggaatttca ggttgaaagg
      481 aagagtaaac tctgtattta cctgagcaga caggatatgc cccatattgt tatcgaaact
      541 gtcatcgttc ggattatccc aataatcacc cgagttattc aggatatggg caccaaagaa
      601 gttattggta tatttaccgt aactgtacat ccgttcccct gttttttcag aaacgaccca
      661 accggtatta tcttcattac gtaaccaggg tgaagacaaa gtcgtcgtaa agttagccgc
      721 acggctggca ccaccggaaa ggttctggcg atgacgcgaa taagaaaggc taccggccac
      781 tttccaccaa tcgaacaact ctgtactcag gttggtacgg aaagaataac gtttataata
      841 ctgccggtta ccatatccct ggtcgtccag ataaccgccg gagaagaaat aggctgtttt
      901 tccaccattg gcctgaccac ttatatccac actataatcc tggcgcagtt tacgggagaa
      961 gatagctttg tagacatccc aatcatcttc atcccagaca tattccagat taggattcat
     1021 gtaaggattc ccattgccgt catgcaatac gtaattttca ttgatatgtc tgaacggagt
     1081 gacataaatc agattaccat tcgaatcttt tgtagccttt acctgtttgg tcaatgcctg
     1141 cgacgaagca taatcgcccg cctgttgcat attcatgccg tcataaagaa gggcatcata
     1201 atacaaggca taccaggtat tttccagctg ctggtacgga tcggcttttt tcggattctt
     1261 gacagcatta tccgaagtac cccaacctcc gcggaagtta atacgcggtt tttctgattt
     1321 accccgcttg gttgtaatca ttacgacgcc gtttgctgca cgcgaaccgt agagcgaagt
     1381 ggccgccgca tccttcagca ccgtcatcga ttctatgtcc gtaggattga tctgattcag
     1441 ttttccatcg taaggcatcc cgtccacaat atataacgga tcggcctttc cggacatgga
     1501 agcaatacca cggatctcca cacgggcatc agctccgggg ttaccctgta cattcacaac
     1561 attcacaccg gcactcatcc cctgcaatgc ttccgcaaag ccggagccca tgatcttttc
     1621 gagtttttca gcttttacaa cggaggccga tccggtgaag gttgatttct tagccgttcc
     1681 ataggctacg acaacgactt catccaggtc ctgtgtcgca tcacttaatt ttacatttaa
     1741 aatagattgt ccgttccaag tgatctcctg agtggccagg ccgacaaagg aaataacaat
     1801 aaccgctccc cgccgaacat tatccagcgt aaactttcca tcgatatcgg ttatcgtacc
     1861 gatagtggtt cctttcacta caacagaagc tccggcgaca ggtcccatct ggtcctctac
     1921 caggccggtt accttattac cctgttgtac taccatcgtt tccggacctg taggattggc
     1981 agcaatcgca cctgccgcac ctaataatac agaaatcatt agtgatctaa ttagttttga
     2041 gttggtccac atagctaaat tcaagtcttt aattaaataa aattaatcac aatagcgttc
     2101 atttcattag aggttacact tttctaagat aaaagtgact ggcatacatt tcaataaaat
     2161 aaagttaact aaaacaaaga tatactgatc attacacaca acatccttct atatttccac
     2221 tctacaaact acagtatctc catcagcaaa tataacttat cattatttaa tacaagcata
     2281 attatgtata tttattgctc taataaatat attttaacca ccatttaatt gattttttta
     2341 tctaaaatcc acattcaaac aatgacatac atattgggat gaaaaatcaa taacagttgc
     2401 aatcaaaaac attttttaac cattaacgca ttacataaac cataaaaaaa cggcaacccg
     2461 aaaagccgga ttgccgtttt tatatcacaa aatgtttaac tattaatgta tcaccattta
     2521 ttagttgttt tcaggacgaa gtttacgaac aacagcacct gcacgccaca tttcactttc
     2581 gcgaagagca gccagttctt tttccagacc ttcacgatag tcaggcttgc tgtttgtgtc
     2641 gatagaacgc tgtgcttcgt taccgcaggc aacttcgcta tacaacttct ggaacaccgg
     2701 ttttgtagca tcgtggaacg ggcccatcca gtccaaagca ccacgctgtg cagttgttga
     2761 acagtttgca tacatccagt ccataccgtt ttctgcgaac aacggcatca atgactgagt
     2821 cagttcttct actgtttcat tgaatgcttc agaaggttcg tgaccgtttt cacgcaaagt
     2881 ttcgtactga gccaacagta atccctggat agctcccatc aaagtaccac gttcgccggt
     2941 caggtcagaa taaacttctt tcttgaatgt tgtttcaaac aagtaaccag aaccaacacc
     3001 gatacccagt gcaatcacgc gatcccatgc tttgcctgtt gcatcctgga agattgcgta
     3061 gcttgagttc agaccacgac cctgcaagaa catacggcgc agtgaagtac ctgaaccttt
     3121 cggagcaacc aggattacgt ctacatcagc aggagggatg atgtttgtac gttctttgta
     3181 agtgataccg aatccgtgag agaaatacaa agccttaccc ggagtcaggt attttttgat
     3241 gcgcggccaa acttcaatct gagcagcatc tgaaagcaga tactggatga tagttgcttt
     3301 ttcgcatgct tcttcgatat cgaacagtgt ttcgcccggt acccaaccgt cagcaacggc
     3361 cttttcccag gtcttaccac ctttacgttg tcctacaatt acgttaaaac cgttgtcgcg
     3421 caggttcagg ctctggccag gaccttgtac gccgtaacct attacagcga ttgtttcgtc
     3481 tttcaatact tctcttgcct tttccaacgg aaattcttcg cgggttacta cgttttcgtc
     3541 aacgccgcca aaattcatta ctgccatttt ctttttacta ttaaaatgta tataaaataa
     3601 tttgtttttc agatccaggt aacggcagcg cggctgatgg ctttgccgtc gttacagatt
     3661 gccatattat atttatcgag ggatacttcc tggttatgga gagtcagctc catcccatac
     3721 tttccttcgg actgataagc tatttcgaaa cggcttatct ctttttctcg gaacagactg
     3781 atatcgaaca agtcgagcag gtgttccatg tatttgatac tgttcaggtg gccgtttacg
     3841 tccaggtcac tatacttcac acggtaaggt tcgccggaag tgttgttttc caccggagca
     3901 attttacccg gtttttcaat cggacaggga cggtcggtga tataagcact caggccctcc
     3961 acatcgagca aggtcgggcg gcgggtttcc atatcgatag ccgcccagat agagcgggca
     4021 aagccaaagg tcttgccttc gccgttcacc agttcaaagc aacggctggt aaacaactta
     4081 ccgacctcat ccacccaggt atataaagtt acggattcag acatggcagg ataagaagtc
     4141 atctcgatag ccagacggga aagaacccag gcggtatgcc tttcggtcat atcgttatat
     4201 ccgaatccac ggtcggcggc atggcaagaa gcagcatgca acaaataagt tccgatcata
     4261 gggattgtaa tacgtccccg gaagtccgtc agataagact ctgttacgaa atgaaattct
     4321 cctactttgt tcttctccat aatttacttt atttacaaaa tgtttcctta ttattctcag
     4381 acatgttttt cctgcaactt cttttccatt gcagataaca tgtcgctcag acgttctacc
     4441 ttactcttcg ttatagcaac gcgtccggaa cggataaatt gcaggacacc gatcgtctca
     4501 ctcaattctt taaacaaagc ctgtgtctca tcataatgac cactcttttc caacaccaca
     4561 caatcctcat tcatttcaag gatacgggca ttgtacttac ggatcagatc ctcaaccgtc
     4621 cccatcttga taaagagttc ggtactcagt ttataaagag cgatttcctg gtaaaccagg
     4681 tcttcatccg tattataata ggctttcagg atatccacac gcttgtcgat ctgttttacg
     4741 accttgtcga tcgtatcctc gtcggcaaag gtagtaattg taaacttatg tattcccttt
     4801 atagcagagg gagaaacaga aagcgtctca atgttcagtt gccggcgcgt aaagataaca
     4861 gttatctgat tcagaagacc aacagtgttt tccgaaaaga taataacggt atataattgt
     4921 tttgtattca tagtttctcc tccttactta tcacccaaaa tcatgtttgt cacgcttcct
     4981 ccggccggaa ccatcggata taccatacca caagtttcca cattggcaac caacatatag
     5041 gcaccatcgt gattcaacat ttcagcaatc gcctcatcca agtcttcccg tttatctacc
     5101 gcacgggaag caataccaaa agccttggct atcgctacaa aatccggatt cttcatgatg
     5161 gtattcgaat accgttcgtt gaagaacagc tcctgccact ggcgtaccat tcccaggaaa
     5221 ttgttgttaa gaacgatgat ctttacattc agattttcct gcatgatagt tcccaactcc
     5281 tggatagtca tctggatacc accgtcgccg gtaaagaaac agaccgtacg gtcaggcgct
     5341 cccagcttcg ctccaatggc ggcgggaagg ccaaagccca tcgttcccaa acctcctgaa
     5401 gtaactacgc tgcgtgtttg tttatatttg aaatagcgaa cacccatcat ctggttctga
     5461 cctacatccg taaccagaat cgcatcatta tcggttgctt cggaaacctt acggactact
     5521 tcgcccattt tcagttggcc ttcggtagga tagagttctt tttctattac cttattatat
     5581 tcctcttttt catccggttc gaattcagca ttccattccg gacgcttccg ttcttccagt
     5641 aaagccgtaa tcatcggaat cgtatgcttg gcatttccca gcactttcac gtcgaccggc
     5701 acattctttc cgatctccga attgtcgata tccaggtgga taatctttgc ctgcttggca
     5761 taagtcttca ggtcgccggt tacgcgatca tcgaaacgca taccgatagc aatcagcacg
     5821 tcacattcgt ttgtcttgcg gttcggtccg acatttccat gcatccccaa cataccttta
     5881 tttaatggga agtccgaagg taatgcagac aagcccaata cggtagaacc ggctggtata
     5941 tcgtttttca acaagaattc tttcagttct tcttcagctc ctcccaggat aaccccctgc
     6001 cctaccagac agaatggctt tttggcatta tttatcaatg aagcagccgc ctcgatacgt
     6061 tcctccctga tatccggttc aggttggtaa ctacgaacat aatccacttt ctgatactca
     6121 taatctacca aacccacctg tgcatctttc gccaaatcca gtaccacagg tcccgggcga
     6181 ccggtcgatg cgatatagaa agcacgggaa acggcccaag caatttcttc cgggcggcgt
     6241 atctggtaag cccatttggt aatcggttgt gtgataccga tcacatcaac ttcctggaaa
     6301 gcatctgttc caagcagcgg agacggaacc tggccggcaa tcaccaccat cggtgtactg
     6361 tccatcagcg catcggcaat accagtgatg gtattggttg ccccgggacc cgaagtaacc
     6421 accgttactc ccacttttcc ggaaacacgg gcatatccct gtgcagcatg tgttgcacct
     6481 tgttcgtggc gcaccagaat atgttttaac tgatctctgt aatcgtataa actatcgtaa
     6541 attggtatcg cctgcccacc cggataaccg aagatagtat ctactccttc agcgatcagc
     6601 gctttcagca aagcttccga accggttatc ttttgtttgt ccatctctaa aatatagtat
     6661 ttggtgttta ttaatcttct actattcgta caccgccctt atcggccgaa gcaaccatct
     6721 ttgcatatgc tttcagtgct ttcgataccg tacgttggcg gaaaggaggt gtaaaggctt
     6781 ttgttccgcg ggcttcttcc gcttcacggc gtttggccag ttcttcgtct gtcaccttta
     6841 catgtatggt tctttcggga atattaattt cgataatatc gccgtctttc actaagccaa
     6901 tcgctccgcc tgcagccgct tcgggagaaa tatgtccgat tgacaaaccc gatgttccac
     6961 cgctgaagcg tccgtctgtg attaacgcac attctttacc cagatgttta ctctttatat
     7021 aagaggtagg atacaacatt tcctgcatac ccggaccacc cttaggacct tcataggtga
     7081 taacgacgac atcgccggag acgacttgat ctttcaggat accttcgcaa gcggcatcct
     7141 gcgaatcgaa tactttggca gggccggcaa aacggaagat actttcatct accccggctg
     7201 ttttaaccac acaaccgtcc tgtgcaatat ttccatacag aacagccaga ccgccgtctt
     7261 tcacataagc atgttccaca tcgcggatac atccggttgc acggtcggta tccagttctt
     7321 tataataact ttcctgcgat ccgagcacca gattgaaacg gtgggccgga gcacttttat
     7381 aaatattgat tgcttcttcc gttacattta cagaggtaat gcagtattgg tcgatagcct
     7441 cattcaaagt cagaccatcc gcacgtttca cggaaccgtc caccagaccg gcttttacca
     7501 gctcattcat aataccgata atacctccgg cacggttcac atcttccaca tgataagaac
     7561 aactcggagc cactttacag ataaccggtg ttttgcgtga aagcatatcg atgtctttca
     7621 ttgtaaaatc gacttccgct tcatgagcca cggccaacag gtgaaggact gtattcgtcg
     7681 atccccccat ggcaatatcc agcgacatag cattcagaaa ggcctgacgg gtggcaatac
     7741 tgcgaggcaa tacggaatca tcgccgtcac gataatattt aaaggcatta tcaacaatca
     7801 tcttcgcggc ttttttgaac aggcgggtac ggttggcatg tgttgcaaca actgttccgt
     7861 tgccgggaag agccaatcca atcgcttcgt tcagacagtt catagagtta gccgtgaaca
     7921 taccagaaca gcaaccgcag gtcgggcaag cggaacgttc caccttttct acttgttcat
     7981 cgctgataga atcgtcagcc gcttcaatca tggcgtcgat caaatcgagt gcacgtccgt
     8041 ccagattacc ggcttccatc ggaccgccgg atacaaagat tgtcggaata ttcagacgca
     8101 tactggccat cagcataccc ggagtaatct tgtcgcagtt actgatacaa accattgcat
     8161 cagccttatg cgcattcacc atatattcca cactgtcagc aatgatgtcg cgggaaggca
     8221 gagaataaag cattccgtcg tgtcccatag caataccgtc atcaatagcg atcgtattaa
     8281 attctgcggc aaagcaaccg agcttttcga tttccgcttt tacctgctgt ccgatctcgt
     8341 gtagatgcac atggcccggt acaaactggg taaatgaatt cacaatggca atgatcggtt
     8401 taccgaactg ttcttctttc atgccgttgg cacgccataa tgcacgggct ccggccatac
     8461 gtctgccttc tgtgctatag gagcttctta acggattctt catcatatct gtttttatct
     8521 tttagtcaat aaaaaagccc ttctctatat ggagaaaggc ttaagaaata tcttttacga
     8581 cttcacaact tcttacacac ctttctcctt acctactaat gactagaagg accaccacga
     8641 gaataatatg caatacgttg ttcatcatct tttcttattg tctttgtttg tttgacgctg
     8701 caaatgtaga acaataattg atatgcgcaa aggatttaaa agaaaattct tcatttttct
     8761 ttcaattctc aagcaaatac cattttagga ttgcatttta acaggagcaa gagtgtatta
     8821 cttaggaatc ggaaggtata gaagggaaaa aacttcgatt tccaaacaga aacagtaaaa
     8881 agacaaatgt tatctaaaac agattccaga taacattttt atcagataac acgacttacg
     8941 ataacacgta tctcataaga aaatcctatt ctagcgataa aaaagataca tataaactct
     9001 aaatcacata tttattaaca cttgtagact ataaatagcc ttgaaaaaat tcataatagt
     9061 gttctagaaa aaacataagg aagttttctg aagaacataa ggaataaatt tcatctagta
     9121 tcggactaaa ttttgttaac atccgaatga aaatcaccta aaatcaagac taaatccggc
     9181 ataacccacg ctagaagcag ctcaagcgaa gacattttca aaatgacttt cagacagaga
     9241 aagccttaaa tactcaaccg atagacagct cttcaaacat caatcataaa aaaagaccaa
     9301 caagacctgc attcaaacat cattctgatt tacacaacca tcaaatgctt gcgctttttc
     9361 cgtgcgacca agcccccgcc ccataattca tcacccacag agagcaataa tagcactttg
     9421 acattttgcc agttcacggt ttgataagcc gtttaagtaa acgattcatt aaatatatcg
     9481 ccgatttcct aatatacagt atttcatatt ttgatttgga taaacaataa atataataat
     9541 ttgtatcttt gaccccaata gcaattaaga aactgatcgt taataaaaat atgaaacact
     9601 acaacttcga cgaagttatc gaacggcatg ggacgagttg cgtgaaattc gaccgtttga
     9661 aagagatgtt cggtgacgag aatctgatac cactatgggt ggcggatatg gatttccgca
     9721 caccggactt tattgtagag gccctgaaga aacgttgtga gcacgagata ttcggctata
     9781 cattcggctc cgacgagtat tacgagagta tcatcaattg ggtacactac aaacataact
     9841 ggaaaataca acgggaatgg atcagctata tcccgggaat cgtgaaggga atcgctttcg
     9901 ctatccaatg ctttacgcaa aaaggagata aggtcatcat ccagccccct gtttatcatc
     9961 cgttccgcat cgttccggaa aaaatgaagc gtgaggtcgt ttataatccg ctaaagatgg
    10021 tagatggtgt ttatgagatg gatttcgatc atcttgaatc tattatagat gataaatgca
    10081 aggtattgat cctctgcaac cctcacaatc cgggcgggat cgtctggaaa aaggaaacct
    10141 tggtccgatt ggccgagatt tgcgccaagc acaatatttt ggttatctcc gatgagattc
    10201 atgcggaaat ggcctatcct cagtatacgc attatccatt cgcctccgta tcggatactg
    10261 ccgcttcttg cagcctaact ttcatggcac cgagcaagac gttcaatatc gccggtatcg
    10321 tgacttccta cgcaatcgtt cccaatgatc gcatccggga agaattttat tctttccttg
    10381 aggccggaga gtttggcgat ggcacgatct tcgcttatac ggcgacaacc gccgcttaca
    10441 cctatggtgc cgaatggttg caacaaatgc gaatgtatat catggagaat gtacgtttcg
    10501 tggaagagtt catgaaacta catctcccca agataaaagt ttaccagccc caagcctcct
    10561 tcctcgtttg gttggattgc agggaactgg aattaagtca agatgaactc gtacacctgt
    10621 tcaaagacaa agccggacta gcgctgaacg acggaagtat cttcggcccc gggggagaag
    10681 gccatatgcg tttgaacatt ggttgccccc gctctgtttt agataaagcg atgaacgctc
    10741 ttaaaaaggc ggtggataag aaataaaatc gtatctttgc gagcatttct atacatattt
    10801 aaaatacaag acaaatgaaa attacagcaa acaaatacgt tgcggttaca tacgacctga
    10861 acgttggcga aggtgaagaa cgtgagttaa tggaaaaagc gacggtcgag gctcctttga
    10921 aattcatcta cggaacaggc atgatgcttc cggcattcga gaaagccttg aacgggctgg
    10981 aagtaggtgg cacgttcaac ttctccatcg agccagccga ggcttatggc gaatataacg
    11041 aggagcacgt attggatctt ccgaagaata tcttcgaggt ggacggtaaa ttcgacgccg
    11101 agatgatcaa ggaaggtaat accgtcccaa tgatggattc taatggcaac cgtatgaacg
    11161 gctctgtatt ggaagtgaag gatgatatcg tggtaatgga cttcaaccat ccgttggctg
    11221 gcgagacttt gcacttcagc ggcgaggtaa tcgacgtaca cgaaccgact gcggaagaga
    11281 tcgcagcctt ctccgctccc gcaggtggat gc
//
