LOCUS       c00056_gnlPro..        14862 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|HPPNPDHL_56.
ACCESSION   c00056_gnlPro..
VERSION     c00056_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 12:02:05
            Original ID  :: gnl|Prokka|HPPNPDHL_56
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14862
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14862
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[326:4862]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      327..4862
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14862
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14862
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(195..299)
                     /locus_tag="ctg56_1"
                     /transl_table=11
                     /translation="MFVSIVCKCTLLFMNEEIIFCFYLPVNVFKDTFY"
     CDS             327..737
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_2"
                     /sec_met_domain="Glyoxalase_4 (E-value: 5.8e-27, bitscore:
                     85.0, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELTHIEHLGIAVKSIEACLPYYEGVLGLKCYNIEVVADQKVKTA
                     FFKVGQTKIELLEPTSEDSTIAKFIEKKGEGIHHIAFAVPDVQAALNEAEEKGVKLIDK
                     APRGGAEGLNIAFLHPKSTCSVLTELCMPGNK"
     CDS             774..2327
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_3"
                     /sec_met_domain="CT_Btheta (E-value: 2.2e-292, bitscore:
                     960.5, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKVKELIALREQARLGGGEKRIESQHKKGKYTARERIAML
                     LDEGSFEEFDMFVQHRCTNFGIEKTKYLGDGIVTGYGTIDGRLVYIFAQDFTVFGGALS
                     EALAMKICKVMDQAMKMGAPVIGLNDSGGARIQEGVNALAGYAEIFQRNILASGVVPQI
                     SGIFGPCAGGAVYSPALTDFNIMTRGTSYMFLTGPKVVKTVTGEDVTQEQLGGASVHTT
                     KSGVAHFAVDTEEDGLQLIRKLLSFLPQNNLEETPLVECKDPIDRLDDVLNDIIPDNAN
                     QSYDMYEVIGTIVDNNEFLEVHADYAKNIIVGFARFNGQSVGIVANQPKVMAGCLDSNA
                     SRKAGRFVRFCDAFNIPLVTLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKITV
                     TLRKSYGGAYCVMSSKHLRGDMNYAWPTAEIAVMGPSGAVEVIFAKEVAAAEDPKACAA
                     EKEAEYKKAFANPYNAAQYGYIDDVIEPRNTRFRIIRALQQLQTKKLSNPAKKHDNLPL
                     "
     CDS             2349..3242
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_4"
                     /sec_met_domain="OAD_gamma (E-value: 3.5e-13, bitscore:
                     40.9, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MINKKIGVLLLLMVLFSMGAKAQLTTSVKLNEVLVVNEDNFVDDY
                     GKRHPWFELFNNSAGTVDLRGCFLTNDKSNPRKYMIPKGDVLTKVPPRQHLLFWADDQP
                     TKGTFHVNFTFDPNKDNYLALYDSDGTTLIDEVTIPAGQKADVSYGLDLDGVGNWSILD
                     KVTPSTNNLTLDSNAKLENFQRNDPWGIGMTITAMAVVFLGLIILYLVFKQIGNAAIKA
                     SKRNAQKAAGTGAAVSANIGQESGEIFAAIATALYEMSDDNHDIENTVLTIHKVQRSYS
                     PWSSKLYSLRQTPNKK"
     CDS             3266..3697
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 63.7; E-value:
                     3.5e-20)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_5"
                     /sec_met_domain="Biotin_lipoyl (E-value: 1.5e-20, bitscore:
                     63.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKSFKYTINGNTYKVHINSVVDDVAEVEVNGTPYNVKMEKPAKKQ
                     MVTLKRPAQAPTNASGEPVITRQAAPSVAGAVKSPLPGVILSVDCKVGDTVKRGQKILV
                     LEAMKMENNINADRDGKIVEIKVNKGDSVLEGADLVVIG"
     CDS             3702..4862
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_6"
                     /sec_met_domain="OAD_beta (E-value: 1.4e-153, bitscore:
                     501.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQESFLQFLGENIQIFLSYTGFANATPGHIVMLLVGLLFIFLAIK
                     YEFEPMLLIPIGFGILIGNIPFKDAGLQLGIYEEGSVLNILYQGVKQGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYIIALQMGFDPSQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPIIQPPFMRLLTTKKERVIRMKPPRAVSQTEKIVFP
                     IVGLLLTAFLVPSGLPLLGMLFFGNLIKESGVTRRLAETARGPLIDVITILLGITVGAS
                     TQATQFLTLNSIKIFGLGALSFVIATCAGVLFVKFFNLFLKEGNKINPLIGNSGVSAVP
                     DAARISQNVGLEYDPSNYLLMHAMGPNVAGVIGSAVAAGILLGFLG"
     CDS             complement(5144..5860)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_M22"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_7"
                     /sec_met_domain="Peptidase_M22 (E-value: 7.2e-28, bitscore:
                     88.7, seeds: 111, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSLILNIETSTSVCSVALSEGEEVVFEKASFEGPSHAALLGVYME
                     EALEAAKSKGIKLDAVAVSSGPGSYTGLRIGVSVAKGLCFGYGIPLIGIHTLDILASAA
                     IRKNKEEADCLYCAMLDARRMEVYSSIYDSHLNTIRATTADIVDADSYASFLENGKVCF
                     FGDGAAKCETVITSPNACFIDGIYPLAVNMASLSQKAYDDGRFENVAYFEPFYLKEFQA
                     TIAKNKVLNEALGKNK"
     CDS             6143..6922
                     /locus_tag="ctg56_8"
                     /transl_table=11
                     /translation="LDLSTRIPSIYKDKEMELRSLLLQSLERGKVEFNIFIEYIGKDTP
                     TQINLAAVENYYNQIKEIAEKLNISVPNDWFQTLLRMPDAIKSETLEPDESEWGVVLET
                     VKDAIKHLCDFRIQEGAMLQKLFEQKIANIATLLKEVEKYEGERIEKIKARIMDNLQKI
                     AEKDYDKNRFEQEMIYYIEKLDVNEEKNRLDNHLKYFISTMESGHGQGKKLGFIAQEMG
                     REINTLGSKSNHAEMQKIVVQMKDELEQIKEQVLNVL"
     CDS             6937..7503
                     /locus_tag="ctg56_9"
                     /transl_table=11
                     /translation="MAGKLIIFSAPSGSGKSTIINYLLKQDLHLRFSISATSRAPRGTE
                     KNGVEYYFLTPEEFRSRIANGDFLEYEEVYTDKYYGTLKSEVERILNEGDNVIFDVDVV
                     GGCNIKKFYGDRALSVFIQPPCIDDLRKRLEGRGTDSPEVIESRIAKAEYELGFTGQFD
                     KVVVNDDLETAQKDALKIIREFLNK"
     CDS             7507..7686
                     /locus_tag="ctg56_10"
                     /transl_table=11
                     /translation="MPNIFKNTRFMMGLSIVCGIASLVLGGISLYYKEYIIGGALIFNI
                     FICFINYKGWQKKG"
     CDS             7698..8273
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) CTP_transf_like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_11"
                     /sec_met_domain="CTP_transf_like (E-value: 8e-26, bitscore:
                     81.7, seeds: 65, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLKTGIYSGSFNPIHIGHLALANWLCEFEGLDEVWFVVTPHNPL
                     KKKDDLLDDSLRLEMAQAAIDGYPKFKVCDIEFHLPKPSYSIDTLRALSSNYPDRDFYF
                     IMGADNWLLFPRWKEYEKILQNYKLLIYPRLGFDISIPTIYPNVKKVDAPLMEISSTFI
                     RNAYQTGKDIRFFLPEGVRPYFGSVANQ"
     CDS             8612..8980
                     /locus_tag="ctg56_12"
                     /transl_table=11
                     /translation="MRIDLTRSKTYEVAYPYDGNALDTSNILREHYWTHRDIDFLKKHQ
                     RKMNSLYMVEGVIGAVGGAIFVQTNKYLQAGMENEDFYGWGLEDGERHYRWLSFGYRIY
                     RSEGCLFHLSHPRDQNRM"
     CDS             9182..10912
                     /locus_tag="ctg56_13"
                     /transl_table=11
                     /translation="MNLLELSEQEIIRRNSMEQLRQMGIEPYPAAEYVTNAFSKEIKET
                     FKDDAEPRPVSIAGRIMSRRIMGKASFMELQDSEGRIQVYISRDDICPDENKDTYNVVF
                     KKLLDIGDFVGIKGFVFRTQMGEISVHAQELTVLSKSLRPLPVVKYKDGVAYDGFNDPE
                     LRYRQRYVDLVVNDGVKDIFMKRAAIIKTMRTALDEAGYTEVETPILQSIAGGASARPF
                     TTHHNSLDIDLYLRIATELYLKRLIVGGFEGVYEIGKNFRNEGMDRTHNPEFTCMELYV
                     QYKDYNWMMSFTEKLLERICIAVNGTSESTIDGKTISFKAPFRRLPILEAIKEKTGYDL
                     EGKSEDEIRTICKALKMEIDDTMGKGKLIDEIFGEFCEGTFIQPTFIIDYPVEMSPLTK
                     MHRSKPGLTERFELMVNGKELANAYSELNDPIDQEERFKEQLRLSEKGDDEAMFIDQDF
                     LRALQFGMPPTSGIGIGIDRLVMLMTGQTTIQEVLLFPQMRPEKTAKKDNADKYVALGI
                     SEEWVPALQKAGYLTVDTLKEANANKLRQELCELNKKYKLELQNPTIQEIEAWIANVGE
                     "
     CDS             10925..11920
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) F420_oxidored"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_Gly3P_dh_N"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_14"
                     /sec_met_domain="F420_oxidored (E-value: 7.9e-10, bitscore:
                     30.1, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_Gly3P_dh_N (E-value: 1.8e-35,
                     bitscore: 113.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDLPGKIAIMGGGSWATALAKIVLSTQDSINWYMRRPDRIEEFKQ
                     LGHNPCYLTAVKFDTNKINFYSNINQAIKDSDTLIFATPSPFLKQHLKKVKTSLKDKFI
                     ISAIKGIVPDENMLITDYFAEYYKVPTENIAVIGGPCHAEEIALERLSYITLACSDIEK
                     VRTISPVFKNQYLKNSFCKDVTGIEYAAVLKNVYAIAAGICHGMKYGDNFQAVFISNAI
                     EEMRNFVDAVHGLERDITDSVYLGDLLVTAYSRFSRNRTFGTMIGKGYSVKTAQLEMEM
                     IAEGYYGTKCMREINEKYKVNMPILDAVYDILYEKKSPTTVIRQLTETFK"
     CDS             11929..13272
                     /locus_tag="ctg56_15"
                     /transl_table=11
                     /translation="MKNISLNIDKALGTVSKEQVYAQEAKAMECIATLHNGNGAGNDFL
                     GWLHLPSSITDAELADIENTANVLRSKCEVVVAIGIGGSYLGTKAVVEALNNSFDWLQN
                     DRKNPVMLYAGHNIGEDYLYELSEVLKGKQFGIINISKSGTTTEPALAFRILKKQLEDA
                     VGKEEAKHRIVAITDAKRGALRTLADQEGYKTFIIPDNVGGRFSVLTPVGLLPIAVAGI
                     SIRDLVAGAVSMEKATDASVPFADNMAAIYAATRNELYKSGKKIEILANFHPKLHYIAE
                     WWKQLYGESEGKDGKGIFPASVDLTTDLHSMGQWIQDGERTIFETVISVEATDHSVLVP
                     TDEADLDGLNFLAGKHVDEVNKMAELGTQLAHVDGGVPNIKVTMPEVSAFYIGQLFYFF
                     EKACGISGYMLGVNPFNQPGVEAYKKNMFALLNKPGYEKESEAIKARL"
     CDS             complement(13343..13618)
                     /locus_tag="ctg56_16"
                     /transl_table=11
                     /translation="MNRGELVQSLVEETGLPKNVVRTVVNALPTVVAKGIREGESISMK
                     GFGSFVPWQQSERLARNPKTGEEVMITPRVSVKFKAGSDLLKELNE"
ORIGIN
        1 ggcacggacg ctatcatgga caggggcttc ttccgccatt taaaaaacat ttggctaggt
       61 ctggatgtgt ttaacatatt agacatcaaa aacgttagtt cctactattg gataacagat
      121 gtatataatg tccaatacgc agttccaaac tatctgaccg gacgtcaatt gaacgttcgt
      181 ctgattgtcg atttttaata aaatgtatct ttaaacacat ttactgggag ataaaaacaa
      241 aaaattattt cctcattcat aaaaagtagt gtacatttgc acacaataga aacaaacatt
      301 tactaaatct ttaaattatt attgacatgg aacttacaca tatcgaacat ttaggtatcg
      361 cagtgaagag tatcgaggct tgtttaccct attatgaagg cgttcttgga ttaaaatgct
      421 acaatatcga agtagtagca gaccaaaaag taaaaaccgc atttttcaag gtaggacaga
      481 ctaagattga attactagag ccgaccagcg aagatagcac gatcgcgaaa tttatcgaga
      541 aaaaaggtga aggtatccac catatcgcat tcgcggtacc tgatgtacag gcagctttga
      601 acgaggctga ggaaaaaggc gttaaattaa tcgataaagc tccccgtggt ggcgcggaag
      661 gcttgaacat cgctttcctt cacccgaaat caacttgcag cgtattgaca gaactttgca
      721 tgccgggcaa caaataatta atccgttcat ttctaacaac aaatcaaaat acaatgagta
      781 accagcttga aaaagtaaaa gagctcatcg cacttcgtga gcaagctcgc ttgggtggag
      841 gagagaaaag aatcgaatca cagcacaaaa aaggcaaata taccgctcgt gagcgtatcg
      901 ccatgttgct tgacgaaggt agtttcgagg aattcgacat gtttgttcaa caccgttgta
      961 caaacttcgg tatcgagaaa actaaatatt taggcgatgg tatcgtaaca ggttatggta
     1021 cgatcgacgg acgtttggta tatatcttcg ctcaagattt caccgtattc ggtggagcct
     1081 tgtctgaggc tttggctatg aagatctgta aagtaatgga tcaagccatg aagatgggcg
     1141 ctcccgttat cggtttgaac gactccggtg gagctcgtat ccaagaagga gtaaatgcct
     1201 tggcaggata cgcagagatt ttccaacgta acatcttggc ttccggtgtt gttccccaga
     1261 tttccggtat cttcggccct tgcgccggtg gagccgttta ttctccggct ttgacagact
     1321 tcaacatcat gacacgtggt accagctata tgttcttgac tggtccgaaa gtcgtaaaaa
     1381 ccgtaacagg tgaagatgta acccaagagc agttgggtgg agccagcgta cacactacca
     1441 aatcgggtgt agcccatttc gctgtcgata cagaagaaga tggtttgcaa ttgattcgta
     1501 aattgctcag tttcttacct cagaacaact tagaggaaac gccgttagtt gagtgcaaag
     1561 acccgatcga tcgtctggat gatgtattga acgatatcat tcccgataac gccaaccaat
     1621 cttacgatat gtatgaggtt atcggtacga tcgtcgataa caacgagttc ctagaggtcc
     1681 atgcggacta cgctaagaat atcatcgtag gtttcgctcg tttcaacgga caatccgtcg
     1741 gtatcgtagc taaccagccg aaggttatgg caggatgctt ggatagcaac gcatctcgta
     1801 aagcaggtcg cttcgttcgt ttctgcgacg ctttcaatat tcctttggta acattggttg
     1861 acgttccggg attccttccg ggtacaggtc aggaatacaa cggtgtaatc cttcatggcg
     1921 ctaaattgct ttacgcttat ggtgaggcta ccgttcctaa gattaccgtt acattgcgta
     1981 agtcttacgg tggagcttat tgcgtgatga gttctaaaca tttacgtggt gatatgaatt
     2041 acgcatggcc gacagccgag atcgccgtta tgggcccgag cggtgccgta gaggttatct
     2101 tcgccaagga agtagcagcc gctgaagatc cgaaagcatg cgcagcagag aaagaagctg
     2161 aatataagaa agcattcgct aatccttata acgcagctca atacggttat atcgacgatg
     2221 ttatcgaacc gcgtaacact cgtttccgta ttattcgtgc tttgcagcaa ttgcagacta
     2281 agaagttaag caatcctgct aagaaacatg ataacctgcc tctataatcc gtaaaacagg
     2341 agatgaatat gataaataag aaaatagggg tattgctact gttaatggtt ctcttcagta
     2401 tgggagccaa ggcacagttg actacctccg ttaaattaaa tgaagtgcta gttgtcaatg
     2461 aagataactt tgttgatgac tatggaaaac gccatccatg gtttgagtta tttaataact
     2521 cagcaggtac ggtggattta cgaggatgct tcttaacgaa cgataaaagt aatcccagaa
     2581 aatatatgat cccgaaggga gatgtactta ccaaagttcc tccccgccag catcttcttt
     2641 tttgggcaga tgatcagcca acaaaaggga catttcatgt aaacttcaca ttcgatccaa
     2701 acaaagataa ttatctagcc ttatatgatt cagatggtac aactttgatc gacgaggtga
     2761 caatccctgc cgggcaaaaa gcagatgtta gttacggtct ggatcttgat ggagtaggaa
     2821 attggagtat ccttgacaaa gtgactccta gcaccaataa tctgacgtta gattcgaatg
     2881 cgaaacttga gaacttccaa cggaacgacc catggggtat tggtatgacc ataacagcca
     2941 tggcagtcgt attccttggc ttaatcattt tgtatctagt attcaagcag atcggtaacg
     3001 cagcgatcaa agctagcaag cgtaacgctc aaaaagccgc aggaacaggt gctgccgtat
     3061 cagccaatat cggtcaagaa tcaggtgaaa tttttgccgc tatcgctacc gctctttatg
     3121 agatgagcga tgacaaccac gatatcgaga acacggtatt gactatccac aaggttcaac
     3181 gcagctattc accatggagt tctaagcttt attctctgcg tcagactcca aataaaaagt
     3241 aatcatccta aaatccaatt gacgaatgaa aagttttaaa tataccatta acggtaacac
     3301 atataaagta catatcaact cagttgtaga tgatgtggca gaggtagagg taaacggaac
     3361 cccttataac gtaaaaatgg agaaacctgc gaaaaaacaa atggttacat tgaaacgtcc
     3421 ggctcaagct ccgaccaatg ccagcggtga acctgttatc acccgtcaag cagctccaag
     3481 tgtagccggc gctgttaaat ctccgctgcc aggtgtaatt ttaagtgtag actgtaaagt
     3541 cggcgataca gttaagagag gccaaaagat cttggtattg gaagccatga agatggaaaa
     3601 caacatcaat gccgatcgtg acggtaaaat tgtagaaatt aaagtaaaca aaggcgactc
     3661 tgtattggaa ggtgcagatc tcgttgtaat cggttaatga tatgcaagaa agtttcttac
     3721 aattcctagg agaaaatatc caaatatttc tctcctatac aggatttgcg aacgcgactc
     3781 cagggcatat cgtgatgcta ttggtaggtt tgctgttcat attcctagcg attaaatatg
     3841 aattcgagcc aatgcttctg atccctattg gtttcggtat cttgatcgga aatatccctt
     3901 tcaaggatgc cggattacaa ttaggtatat acgaagaggg ttctgtattg aacattttat
     3961 accaaggagt gaaacaaggt tggtatcccc ccttgatatt cctcggtatc ggtgccatga
     4021 cagacttctc cgctttgata tccaatccta agttaatgct agtcggagct gccgcccaat
     4081 ttggtatttt cggtgcttat atcattgcat tgcaaatggg atttgacccg agccaagccg
     4141 gtgctatcgg tattatcgga ggagctgatg gtccaaccgc aatcttcttg tcatccaagt
     4201 tagctcctaa cttgatgggt gctatcgctg tatccgcata ctcatatatg gcattggttc
     4261 ctattatcca gccaccgttt atgagattgc ttacaacgaa gaaagaacgt gtgatacgta
     4321 tgaaacctcc aagagccgtt tcacagacgg agaaaatcgt tttcccgatc gttggcttgc
     4381 tattgacagc cttcttggta ccgtctggtt tgccattgtt aggaatgttg ttcttcggta
     4441 acttgatcaa ggaaagtggt gttactcgcc gtttggcaga gacagcccgc ggcccgctga
     4501 tcgatgttat tacgatcttg ttaggcatca cggtaggtgc ttctacacaa gctacccagt
     4561 tcttaacatt gaactctatc aagattttcg gtttgggtgc gttgtcattc gttatcgcta
     4621 cttgtgccgg tgtattgttc gttaagttct ttaacctgtt cttgaaagaa ggcaacaaga
     4681 tcaatccgtt gatcggtaac tccggtgtat ccgccgtacc tgacgctgcc cgtatttccc
     4741 agaacgtagg tttggaatac gatccaagca actacttgtt gatgcacgct atgggtccga
     4801 acgtagcagg tgtaatcggt tccgctgtag ctgccggtat cttgctagga ttccttggtt
     4861 aataaaacaa ctatctatat taaaaaaggc gaggtccgaa aggatcccgc ctttttatgt
     4921 tattgttctc agttagcttg ctctatagga accggactaa tctccgtact cgtatcctcc
     4981 accaacgttg tcccgaggaa caaccagatc atcaaaagga ttatagcaac aaccacacca
     5041 aataccaata gcgtattcac acttttcttt ctcatgtctt taactgattt attcatttta
     5101 gaataaacag ccggaacatg aatttggttg tgtaccctta ctcttatttg tttttcccta
     5161 acgcctcgtt cagcactttg ttcttagcga tcgttgcttg gaattctttc aaatagaaag
     5221 gctcaaaata agccacattc tcaaaacggc catcatcata tgctttctgc gacaaggatg
     5281 ccatatttac agctaatgga tagataccat ctataaaaca ggcgttcgga gaagtgatta
     5341 ccgtctcaca tttagcggca ccgtctccaa agaaacaaac cttaccgttc tctaaaaaag
     5401 aagcatacga atcagcatct acgatatcag cagtcgtggc acgtatcgtg ttgagatggg
     5461 aatcataaat cgaagagtag acttccatac gacgggcatc caacatagcg caatacaagc
     5521 aatcggcctc ctccttattt ttccgaatag cggcagacgc taaaatatcc agcgtatgaa
     5581 taccgatcaa aggaatacca tacccaaagc ataatccttt agccacagac accccgatgc
     5641 gtaaccccgt ataagatccg ggtccgctac ttaccgccac agcatccagt tttatccctt
     5701 tcgacttcgc ggcttctaat gcctcttcca tataaacgcc caataacgcc gcatgagacg
     5761 gcccctcgaa ggaagccttc tcaaagacca cctcctcccc ttccgacagg gctactgaac
     5821 atacggaagt ggatgtctcg atatttaaga tcaatgacat aataattaac tattaacaat
     5881 tgataattga acgaacaaac aatctcaatc cttcaatctg attaggctgc gaaggtatac
     5941 aaaaattcat tatgctatca aggcagccct atgagaaaca tctatttatg agaaaataaa
     6001 catcaaatct aaaaggaaac cactatcttt gcgcaaactt ttgagaaaaa tgatacaatc
     6061 aatgactggg ttcggtaagg ttactgccga gctcccttca aaaaaagtaa ccgtagagat
     6121 aaaggcttta aacagtaagc aattggattt gtccacccgt atcccttcca tatacaagga
     6181 taaggaaatg gagcttcgga gcctgttact tcaatctttg gagcggggaa aagttgagtt
     6241 caatatcttt atagaatata taggcaaaga tactcctaca cagatcaatc ttgccgccgt
     6301 agagaattat tacaaccaaa tcaaggagat cgcagagaaa ctaaatatca gcgttccgaa
     6361 cgattggttc cagaccttgc tccggatgcc ggacgcaatc aagtccgaga ccctagaacc
     6421 ggacgaatcc gaatgggggg tggttttaga aacggtaaag gacgctatca agcacctgtg
     6481 tgatttccgt atccaagaag gagccatgct tcaaaagctt tttgagcaaa agatagccaa
     6541 tatcgccact ctgttgaaag aagtggagaa atacgagggg gaacgtatcg agaagatcaa
     6601 ggctcgtatc atggataacc tgcaaaagat agccgagaag gactacgaca agaatcgttt
     6661 cgagcaggag atgatctatt acatcgagaa gctggatgtc aacgaggaaa agaaccgtct
     6721 ggacaaccac ttgaaatatt ttatctcaac catggaatcc ggtcacggcc aaggcaagaa
     6781 gctcggtttt atcgctcagg aaatggggcg tgagatcaat acgctcggat caaagagcaa
     6841 ccacgccgag atgcagaaga tcgtggtcca gatgaaagac gagttggaac aaatcaagga
     6901 acaggtacta aacgtattat aataagatta acgagaatgg ctggcaaatt aattatcttc
     6961 tccgcaccct cgggttccgg aaaatcaacc attattaatt atcttttgaa acaagattta
     7021 caccttcgtt tctccatctc ggctaccagc cgggctccgc ggggaaccga gaagaatggt
     7081 gtggaatatt atttccttac gccggaagag ttccgcagtc gtatcgctaa tggagacttc
     7141 ttggaatatg aggaggtgta taccgataaa tattacggta cgttaaaaag cgaggtagag
     7201 cgtatcttga atgaagggga caacgtgatt ttcgatgtgg atgtggtagg cggatgcaat
     7261 atcaagaaat tctatggaga ccgtgccctg tctgtcttta tccaacctcc ttgcatcgat
     7321 gacctacgga agcgattgga aggacgggga acagacagcc cggaagttat cgaaagccgt
     7381 atcgccaagg ctgagtatga attagggttc acgggacagt ttgataaggt tgtcgtaaac
     7441 gatgatctgg agactgccca aaaagacgcg ttgaagatca ttcgtgagtt cttaaacaaa
     7501 tagtctatgc ctaatatatt caagaatacc cgttttatga tggggctttc tatcgtttgt
     7561 gggatagcga gcctcgtatt aggtggtatc agcctgtatt ataaggagta tatcatcggg
     7621 ggtgccctga tatttaatat attcatttgt tttatcaact ataagggttg gcaaaagaag
     7681 gggtaagtat aaatcggatg agactcaaga ccggcatcta cagtggatcg ttcaatccca
     7741 ttcacatagg ccatctcgcc ttagcgaact ggctatgtga gttcgaggga ctggatgagg
     7801 tgtggttcgt ggtcacgcct cataatccgc tgaagaaaaa ggatgacttg ctagatgact
     7861 cactacggtt ggaaatggcc caagccgcca ttgacggata cccgaaattc aaggtctgcg
     7921 atattgagtt ccacctgccg aaaccttctt attccattga taccttgcga gccttatcca
     7981 gcaactatcc ggatagggac ttttatttta tcatgggagc cgataactgg ctgctttttc
     8041 cccgatggaa agaatatgaa aaaatactcc aaaactataa actgctgatt tatccccgcc
     8101 taggattcga tatctcgatc ccaaccattt atccgaacgt gaaaaaggta gacgctccct
     8161 tgatggaaat ctcctccaca tttatccgta acgcttacca aaccggcaag gatatccgtt
     8221 tcttcctgcc ggaaggagtg cggccttatt tcgggtcagt agcaaatcag tgacatacct
     8281 gcgatagaag atatacttac ttgggctatg aagtatatat cctatgccac ttgaagtata
     8341 tattcttcga gaagggaagt tataccgtga ttatttacag ctttgccatc ttagggcaag
     8401 atgccaaaat tcccattaaa acatgtttta cagcacagcc gttaaagatg atccccgtaa
     8461 catcaaaaca ggctcactcg ataatctttt tggagtatcc aaatatataa tttgagcctt
     8521 gtcaagtgaa taactaacgg ttacaccgag gattactgaa tggtttcccc ggtgtgatat
     8581 tggcattgtt gaacattaag caaagatatt tatgcgaata gacttgacaa gatctaagac
     8641 atacgaggta gcttatccat acgatgggaa tgctttggac acttcaaata tattgaggga
     8701 acactactgg acacatagag acattgactt cctaaaaaaa caccaaagaa aaatgaactc
     8761 tttgtatatg gtggaaggag taattggggc agtcggagga gcgatttttg tccaaacgaa
     8821 caaatatctg caagcgggta tggaaaatga ggatttctat ggctggggct tggaggacgg
     8881 agaaagacat taccgttggt tgagttttgg ctaccggatt tatcggagtg agggctgttt
     8941 attccatttg tctcatcccc gggatcaaaa caggatgtaa agataaaatt attgggtctt
     9001 aagttcatgg cctacaaacc taagatactt caccaaggat cctaagatac tttaccgatg
     9061 aacctaagat actttatcca tgaacaaaca agatcggtga cctcaacctt ttaccacata
     9121 agtcagcata aatcagaaat attttgtact tttgcaccgt attatacaaa ataatagcat
     9181 aatgaatcta ttagaactga gtgaacagga aataataaga cgtaatagca tggagcagtt
     9241 gcgtcagatg gggatagagc cttatcccgc agctgagtat gtaacgaacg cattttccaa
     9301 agaaataaaa gagacattca aagacgacgc tgagccacgc ccggtaagta tcgccggccg
     9361 tatcatgagc cgtcgtatca tgggtaaggc ttccttcatg gaattgcagg attccgaagg
     9421 cagaatacag gtctatatct cccgtgacga tatttgtccg gatgagaata aggacaccta
     9481 caatgtcgtt ttcaagaagt tactggatat cggtgatttc gtcgggatca agggattcgt
     9541 tttccgtact cagatgggag aaatttccgt tcatgctcaa gaattgacag ttttgtctaa
     9601 atcacttcgt ccgctaccgg tcgttaaata taaggacggt gtcgcttacg acggttttaa
     9661 tgacccggag cttcgctacc gtcaacgtta cgtggatttg gtagtaaacg atggcgtaaa
     9721 agatattttc atgaaacgtg cggctatcat caagaccatg cgtaccgctt tggatgaggc
     9781 cggatacacg gaggtagaga ctccgatcct gcaatctatc gccggaggag ctagcgcacg
     9841 tccgttcacg acacatcata actccttgga catcgattta tatttacgta tcgctaccga
     9901 gttgtatttg aaacgattga tcgtcggtgg attcgagggt gtatacgaga tcggtaagaa
     9961 tttccgtaac gagggtatgg accgtacgca caacccggag ttcacttgta tggaacttta
    10021 tgtccaatac aaagactata actggatgat gagcttcact gagaagctgt tggagcgtat
    10081 ctgtatcgcc gtgaacggta cgagcgagag cacgatcgac ggtaagacaa tcagcttcaa
    10141 ggctcctttc cgccgcttgc cgatcttgga ggcgatcaag gaaaagacgg gttacgactt
    10201 ggaaggtaag agcgaggacg agatccgtac gatctgcaag gcattgaaga tggagatcga
    10261 cgatacgatg ggtaaaggta aattgatcga cgagatcttc ggggagttct gcgagggtac
    10321 gtttatccag ccgaccttca tcatcgacta tccggttgag atgagcccgc tgactaaaat
    10381 gcaccgtagc aaaccgggat tgaccgaacg cttcgagttg atggtaaacg ggaaggaatt
    10441 ggcgaacgct tatagcgagc taaacgatcc gatcgaccaa gaagaacgtt tcaaggagca
    10501 attacgcttg agcgagaaag gggacgacga agcgatgttc atcgatcaag atttcttacg
    10561 cgcccttcaa ttcggtatgc ctcctacgtc gggtatcggt atcggtatcg accgtctggt
    10621 tatgttgatg accggacaga caacgatcca agaggtattg cttttcccgc aaatgcgtcc
    10681 ggagaaaacc gcaaagaaag ataacgccga caaatacgta gccttgggta tttccgagga
    10741 gtgggttccc gctttgcaga aagccggcta cctgacggtt gacacgctga aagaagcgaa
    10801 cgccaacaaa ttaagacaag agctttgtga gcttaataaa aaatataagt tagaactgca
    10861 aaatcctacg atccaagaaa tagaagcttg gatagccaat gtaggagaat aaaagcgtga
    10921 tacgatggat ttgcccggaa aaatcgcgat aatgggaggt ggtagctggg ctaccgcctt
    10981 agccaagatc gtactttcaa ctcaagatag tatcaactgg tacatgcgta ggcccgatcg
    11041 tatcgaggag ttcaagcagt tgggacacaa tccgtgttac ctcaccgccg tgaaattcga
    11101 cacgaacaag ataaacttct attccaatat caaccaagcg atcaaggact cggatacctt
    11161 gatcttcgct acgccttccc ctttcttgaa acaacatttg aagaaggtga agacctcttt
    11221 gaaagataag tttatcatct cggcgatcaa gggtatcgta ccggatgaga acatgttgat
    11281 tacggattac ttcgcggagt attacaaggt tccgacagaa aatatagcag ttatcggtgg
    11341 tccctgtcat gcggaagaga tcgctctgga gcggctctcg tacattacgt tggcttgttc
    11401 cgacatcgag aaggtccgta cgatatcccc cgttttcaag aatcaatact taaagaattc
    11461 cttctgtaag gatgtgaccg gtatcgaata cgccgccgta ctgaagaacg tgtacgctat
    11521 cgccgccggt atttgccatg ggatgaaata tggcgataac ttccaagccg tatttatctc
    11581 gaacgctatt gaggagatgc gtaatttcgt ggacgccgta cacgggctgg agcgggatat
    11641 caccgactcc gtctaccttg gcgatttgct ggttaccgct tattcccggt tcagccgtaa
    11701 ccgtactttc ggaaccatga tcggtaaagg atattccgtg aagacagcgc agctggagat
    11761 ggaaatgatc gccgagggat attatggaac caagtgtatg cgtgagatca acgagaaata
    11821 taaagtgaac atgccgatac tggacgctgt ttatgatata ttgtacgaga agaaatcgcc
    11881 gacaacggtc attcgtcaat taacggaaac gtttaaataa aatagcatat gaaaaacatc
    11941 agtttaaaca tcgacaaggc tctgggcact gtctccaagg aacaggttta cgctcaagag
    12001 gccaaggcaa tggaatgtat tgccacatta cataacggta acggagcagg taacgacttt
    12061 ttgggttggt tgcatctccc ctcttctatt acggacgcag agttggccga catcgagaat
    12121 acggcgaacg tgcttcgttc taaatgtgaa gtggtcgtag ccattggtat cggtggtagc
    12181 tatttgggta ccaaagcggt agtagaagcg ttaaacaaca gcttcgactg gttgcaaaac
    12241 gaccgtaaaa acccggttat gttatacgcc ggacacaata tcggagagga ttatctttat
    12301 gaattaagcg aagttttgaa aggtaagcaa ttcggtatta tcaatatctc caagtctggt
    12361 acgactacag agccggcttt ggctttccgt atcttgaaga aacaattgga agatgctgtt
    12421 ggcaaggaag aggctaaaca tcgtatcgta gctatcacgg acgctaagag aggcgctttg
    12481 cgtaccttgg cggatcaaga aggttacaag actttcatca tccctgataa cgtaggtgga
    12541 cgtttctctg ttttgactcc ggtaggtttg cttccgatcg ccgtggcagg tatcagcatc
    12601 cgcgacttgg ttgctggagc tgtttccatg gaaaaagcta cagacgcgag cgttcctttc
    12661 gctgataata tggccgctat ctatgccgct actcgtaacg agttgtataa gagcggtaaa
    12721 aagattgaga tcttggctaa cttccatccg aaattgcatt atatcgcaga atggtggaaa
    12781 caactttatg gagagagcga aggtaaagac ggtaaaggta ttttccccgc atctgtagat
    12841 ttgacaaccg atttgcattc catgggtcaa tggattcaag acggtgagcg tacgattttc
    12901 gaaacggtta tctccgtgga agctacagat catagcgtat tggttcctac agacgaggct
    12961 gatttggatg gattgaactt cttggcaggc aagcatgtag acgaggtaaa caagatggct
    13021 gagttaggta ctcagttagc tcacgtagat ggtggcgttc ctaatatcaa ggtaactatg
    13081 ccggaagtaa gtgcgttcta tattggtcag ttgttctatt tcttcgagaa agcttgtggc
    13141 atcagtggtt atatgttggg cgttaaccca ttcaatcaac cgggtgtcga ggcttataag
    13201 aagaatatgt tcgccctgtt gaataagccg ggatacgaga aagaaagcga agctatcaaa
    13261 gcacgtttat aatacgattt accccataaa aaaacggttt tctcatcacg aggaaaccgt
    13321 tttttcgttt gaatagtttt tattactcat ttaattcttt aagtaaatcg ctcccggcct
    13381 tgaatttgac cgagacacgt ggagtaatca ttacttcctc ccctgttttc ggattacgtg
    13441 ccaatcgctc ggattgttgc caaggtacaa aagatccaaa tcctttcatg gaaatagatt
    13501 ctccttcccg tattcctttc gccacaacag tcggtaacgc attcactacg gttctaacaa
    13561 catttttcgg caatcctgtt tcttccacaa gagattgtac taattctcct ctattcatac
    13621 tagataataa atataccatt cttcaccaga aaagagtccg gtgagaactt agttgtttaa
    13681 tcattgcaaa tatatgaata tttggggaat atcaaaataa catatattaa aaatcaatgc
    13741 atacagaaat attatatacc taaatgtagg tataattgaa cccctttcag atagacaagt
    13801 gagactttgg tagaaatata attaataaga aatagtatac agtattatga tatcacttat
    13861 tcatagcaag ttatagcctt tgaaaattcg ttattaatgc gtttactaga gttctcaccg
    13921 aactacgtca taatttattg attaattatc tcaacgaaat aaatttatat cccttatttt
    13981 tcaatacatc tatcaactca tccagataat tatagaattt atcaatccgg ttagggtgta
    14041 catgtaggtg gatcaaaagt aagcacccat ttaaaccatt tttgtttcat aaaatgaaat
    14101 tccattatat atcatattta tttaatttca agaagctttc ctcccatttc tgttaattcc
    14161 gatttattac gtacctttgt attggttttt aagaaggtaa taacatgatt caagaagcga
    14221 ttatccgata tctgcgtaaa cacaggcagg aatccctttc tcccaaagct gttcttttcg
    14281 atatggatgg tgtattatat gactctatgc gttttcatgc acgggcatgg catgaggtag
    14341 cgacccacca tcagctaact tctcggccgg aagactttta tatgttcgaa ggacgtactg
    14401 gggaaagcac gatcaacgag ctataccaac gcactttcca acgagacgct accgccgagg
    14461 agaagcaaac gatctataaa gagaaagcgg atctattcaa tacctataat gacggtgccc
    14521 ccatgaccgg cgccgcagag gttctaaaag aagtggaagc atccggactg caacgattgg
    14581 tcgtcaccgg ttccggccaa catagcttga tcgataagct aaaccatacc tatccgggac
    14641 atttcaaccg agagaaaatg gttacggctt tcgacgtgaa atatggcaag ccacaccccg
    14701 aaccttattt aatgggactt caaaaagcgc atgtgaagcc taacgaagct tttgtggtag
    14761 agaacgctcc catgggagta gaagctgccg tggcagccaa tatctttacg atagccgtaa
    14821 acaccggacc tctccccgat caagttttat tagatgccgg ag
//
