LOCUS       gnlProkkaICOGMFEM_11   16447 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ICOGMFEM_11.
ACCESSION   gnlProkkaICOGMFEM_11
VERSION     gnlProkkaICOGMFEM_11
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 05:25:50
            Original ID  :: gnl|Prokka|ICOGMFEM_11
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16447
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16447
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[6093:6447]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6094..6447
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..16447
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16447
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             909..3737
                     /locus_tag="ctg11_1"
                     /transl_table=11
                     /translation="MKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFN
                     KNGVKDVYEDPSAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLW
                     KDGIGAIDEHLNGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNE
                     GIRGVESYRATNFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQR
                     WGRYEEVYGESPYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQM
                     SPREVENIHIYPFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVV
                     SDSDAVEYLYTKHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEE
                     VINDRVRDILRVKFLIGLFDAPYQTDLADADREVEKEENEAIALQASRESIVLLKNAGE
                     LLPLDINSTKKIAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGC
                     DLVDAHWPESEIIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLD
                     LPGRQLQLLQAIQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADIL
                     FGDYNPGGKLTVTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGL
                     SYTTFEYSDLDITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNL
                     AGFQRIHLEPGEAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLT
                     VEDYQTRAKAIEAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKV
                     DKVAIAFTRDNNLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVL
                     NDDRVSIAEVKF"
     CDS             3839..4966
                     /locus_tag="ctg11_2"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLAFDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             5037..6086
                     /locus_tag="ctg11_3"
                     /transl_table=11
                     /translation="MKKNILMLSALFLSITAMAQTDVTTGVMRGKDYGVTYMLPKTEIE
                     IVLQATKHTYTPGEFCRYADRYLRLNNVSAEPEEFWTLDKIETRIAGVPDKDNVYFVKM
                     KDKTVAPLMELTEDGIVRSINIPFSGKPAAKTPEAKATESSIDPRSFLTEEILMSNSSA
                     KMAELVAKEIYSIRESKNALLRGEADNMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKK
                     EPKTFTIRLTPKEMKDEVAFRFSRKLGVVANNDLAGEPYYISVTDLKSPDVSATEEGKK
                     KVDGVAYNLPGKAQVTLMYNNKKLFDDQLPITQFGTVEYLAPVLFNKNSTIKVLFDTAT
                     GGLIKVDRE"
     CDS             complement(6094..6447)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg11_4"
                     /sec_met_domain="PqqD_RRE (E-value: 6.4e-10, bitscore:
                     30.9, seeds: 9, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 1.1e-16, bitscore: 53.1,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMEIPEGKVSLLDAVPVRCGHITTEWEGECAVLAYPRFKYEWMRR
                     FLLPKGMSPDIHVRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYVMQ
                     LRKDGFIQLTIRN"
     CDS             complement(6467..7858)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 102; E-value: 4.6e-31)"
                     /gene_kind="transport"
                     /locus_tag="ctg11_5"
                     /transl_table=11
                     /translation="MTEQLKLKLNDSKATRWGALVIVAFTMMVAYYVNDVVAPLKTMLE
                     TDLAWSSTDFGFFTGGYSFLNVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYY
                     AMTGLAGADATLFGINEIFGYKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKEL
                     ATAMGVQVALARIGSQAGYAVAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKL
                     DKQMEAAAIAAGTEDEEEKFSFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELM
                     IIKYGINENVAGTFAGLPALGALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAI
                     PDINYWLVAIVLMIILGIAFSLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIP
                     TLIGWVLDAYCISGKKPDGTNMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEE
                     PNIQK"
     CDS             complement(8012..8401)
                     /locus_tag="ctg11_6"
                     /transl_table=11
                     /translation="MYLLLVILMLIASVLMCFIVLIQNSKGGGLASGFSSSNQIMGVRK
                     TTDFLEKATWTLAAVMVVFSIVSAYTIPSSTGKGGDVILEQAQQEEKTNPYNMPVGTEA
                     PQSEAPAATTPAETPAPAAEAPAAE"
     CDS             complement(8406..9179)
                     /locus_tag="ctg11_7"
                     /transl_table=11
                     /translation="MTPTHLQQWIQHPETLNRDTLYELRTLVARYPYFQSLRLLYLKNL
                     YLLHDINFGAELRKAVLYVADRRVLFYFIEGDRYTLKSRKVSSLFSGDLEKEPSVDRTL
                     SLIDAFLATVPEEHSQHTELDYAVDYTAYLMQEEPGVDAEDESEVPKLRGHELIDDFIQ
                     KSESSDASDTRREFLVEKEEETEEEEEPSVSPVTEELDDSCFTETLAKIYIKQHRYDKA
                     LEIIKKLSLNYPKKNAYFADQIRFLEKLIINAKSK"
     CDS             complement(9184..9708)
                     /locus_tag="ctg11_8"
                     /transl_table=11
                     /translation="MDWIKKAAFASLLVSLLFLVNSCSMKLGLAPISSIDYTKVKTISI
                     ADFQNRAEYVYAPLATEFNQKMKDMFIQQTRLQLVNSGGDLEIDGEITGYNQYNESVDA
                     SGYSSKVKVTLTVNVRYTNNTNHEEDFEQQFSAFQTYDSSKLLTEVQDQLITLMVKDIA
                     EQIFNATVANW"
     CDS             complement(9695..10945)
                     /gene_functions="regulatory (smcogs) SMCOG1112:sigma-54
                     dependent trancsriptional regulator (Score: 379.9; E-value:
                     3.1e-115)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg11_9"
                     /transl_table=11
                     /translation="MTKAEIQQVKLRFGIIGNNEALMRAIDIAIQVAPTDLSVLITGES
                     GVGKESFPQIIHQYSRRKHGQYIAVNCGAIPEGTIDSELFGHEKGAFTGAIGERKGYFG
                     EANGGTIFLDEVGELPLPTQARLLRVLESGEFIKVGSSKVEKTDVRIVAATNVNLTQAI
                     ADGRFREDLYYRLNTVPIQVPPLRERGEDVVLLFRKFASDFAEKYRMPAIQLTEDGKQV
                     LLGYSWPGNVRQLKNITEQISIIETNREINASILKGYLPEQNNMQRLPALFGVKEDKSF
                     GSEREILYQVLFDMRQDVTDLKKLVHEIMAERGTVANPAVATSAYYTPATPAVVPPVTS
                     SVPTIIHPSVKPVTPVDDDFQDTEEYVEESLSLDEVEKEMIRKALEKHHGKRKSAAQDL
                     NISERTLYRKIKEYGLD"
     CDS             complement(10947..12044)
                     /locus_tag="ctg11_10"
                     /transl_table=11
                     /translation="MEDNKIRVGITQGDINGVGYEVILKTFADPVMLELCTPIIYGSPK
                     VAAYHRKSLDLPTNFSIVNSASEAVPNRLSVVNCTDDEVKVEFSKPDVEAGKAALGALE
                     KAIEEYKEGMIDVIVTAPINKHTIQSEEFAFPGHTEYIEQKLGDGEKALMILMKDDFRV
                     ALVTGHIPVKEIAGSITKELIQEKLKIFNRSLKQDFAISAPRIAVLSLNPHAGDGGLLG
                     TEEQEIIIPAINEMAAKGMLCYGPYPADGFMGSDNFTHFDGILAMYHDQGLAPFKALAM
                     DEGVNYTAGLPVIRTSPAHGTAYDIAGKGIASEDSFRQAIYVAIDVFRNRQREKEAHAN
                     PLRKQYYEKRDDSDKLKLDSVEEDL"
     CDS             complement(12050..13105)
                     /locus_tag="ctg11_11"
                     /transl_table=11
                     /translation="MRKHLFYLSMVLVLTLFSACGGGKKGVFTPTSSGRAYEVLVVVEP
                     GLWERPAGRALFDVLDSDVPGLPQSERSFRIMYTAPSNYDATLKLIRNIIIVDVNKDLY
                     TQPKFKYARNVYAAPQSILTIQAPDEASFEKFVEENRQVIIDFFTHAEMNRQISVLKDK
                     HSDYIATKVKSQFDCDVWVPGELTSTKEGENFFWAGTNAATGDQNFVIYSYPYTDKDTF
                     TKEYFVHKRDSVMKVNIPGAREGMYMSTDSLMTDVRPISVQGDYALEARGLWRIKGDFM
                     GGPFVSHVRLDKANQRIIVSEIFIYSPDKMKRNLVRQMEASLYTLKLPGSKQEGTEIPV
                     GVTSKDTTNNK"
     CDS             complement(13176..14216)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF04055"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg11_12"
                     /sec_met_domain="PF04055 (E-value: 1.2e-16, bitscore: 53.7,
                     seeds: 518, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKRPLLGLTLSELQNVVKNLGMPGFSAKQIASWLYGKKVTSIDE
                     MSNLSLKHRELLKEIYEVGAEAPVDAMRSVDGTVKYLYRAGEGHFVEAVYIPDEDRATL
                     CVSSQVGCKMNCKFCMTGKQGFTANLTSNQIINQINSLPERDKLTNVVMMGMGEPLDNL
                     DEVLKALEIMTASYGYAWSPKRVTLSSVGLKKGLQRFIEESDCHLAISLHSPIPLQRRE
                     LMPAEKAFSITEIVELLRNYDFSKQRRLSFEYIVFKGVNDSLPYAKELLKLLRGLDCRI
                     NLIRFHAIPGVNLEGADMETMTAFRDYLTSHGLFTTIRSSRGEDIFAACGMLSTAKQEE
                     NKEELI"
ORIGIN
        1 attttgagga ctgagattaa agtgcaaatc aacgacgcac tgcatgctta cttaccattt
       61 ctgcccgctg tcaaatccag tcaaccccat gactttgtaa cggtctgaaa tttaaaagat
      121 tgcgtaactc attgctaagt agggagggtg aaaaagggat aaatgctact ttatttttca
      181 tcctctaccg ctttctttgg cccaaagata catattcttt tattagcaat caccatatat
      241 ttacaaatat tagctaatac tgacttttcg tgataaaaac aataatcttc catacataga
      301 atatgtgcac cccattgtca tcaatgttca aacagctacc aaagccagta tccgttgacg
      361 gaattacccc ctgcaagagg gaatatctat cttctgtaat ggatatttgc acaaaagaga
      421 tgggaaatta acggaaaaag tctctgaagt taactgaaaa accggaaaga attaaggaag
      481 caatctatcc caaactttgg ttttttcata cccagccttg ggatgtctaa accaaggttt
      541 ggtttagaca tcccaaggtt gaaaagaaag ttcttccgta caagcaacaa ttccgccaac
      601 agattcctat tatataaata caccctcgtt taacagatgt agccgtaata cttgtataca
      661 ccgcgattgc atctactttt caggttatta tagtgttctc tctttctttt taaaagtgaa
      721 tgatatgttt cgtctaataa tgatttgaat tccccggtag cgtcttggag gatattttta
      781 gtaagaggaa gacccttcgg acaataaaag ccgatacttc ggactatttt atccctttat
      841 ttcacacatt agccgtattt ttgtcaacaa aagaaacaat aataaccaag agatttttag
      901 aacatatcat gaagaacctt attgccctaa ccctgctgct tggaggaagc acactgctct
      961 gcgcacaaaa gcctgccaaa acaccggcaa cctacaagcc ggtgaaaagt gaaatgtacc
     1021 gcaaaggttg gatagacttc aacaaaaacg gagtgaaaga cgtgtacgaa gacccctccg
     1081 ccccgctcga agcacgcatc gaaaacctgc tgcaacagat gacgctggac gaaaagacct
     1141 gccaaatggt caccctctac ggttacaaac gtgtactgaa agacgacctc cccacccccg
     1201 aatggaaaga gctgctctgg aaagacggta tcggcgccat cgacgaacac ctaaacggct
     1261 tccagcaatg ggggctgcct ccctcggaca atgcctacgt ctggcccgcc tcgcgccacg
     1321 cctgggcact gaacgaggtg caacggttct ttgtggaaga tacccgtctc ggtatccccg
     1381 tagactttac caacgaaggc atacgcggcg tggaaagcta ccgcgccacc aacttcccca
     1441 cccaactggg actgggacat acctggaacc gtgaactgat tcgccaagta ggactcatca
     1501 ccggacgcga agcccgcatg ctgggctaca ccaacgtcta cgcccccatc ctcgacgtag
     1561 gacgcgacca gcgctgggga cgctacgaag aagtttacgg cgaatctccc tacctcgtag
     1621 ccgaactggg catcgaaatg gtgcgcggct tgcagcacaa ccaccaagtg gccgccaccg
     1681 gcaagcactt tgccgcttac agtaacaaca aaggcgcccg cgaaggcatg gcacgcgtgg
     1741 acccgcaaat gtcgccgcgc gaagtggaaa acatacacat ctaccccttc aaacgcgtca
     1801 tccgggaagc tggcatgctg ggcgtaatga gttcgtacaa cgattacgac ggcatccccg
     1861 tgcagggcag ctactactgg ctcaccaccc gcctgcgtgg cgaaatggga ttccgtggct
     1921 acgtcgtatc cgacagtgac gccgtagaat acctctacac caagcacggc accgccaaag
     1981 acatgaaaga agccgtccgc caaagcgtgg aagccggact gaacgtacgc tgcaccttcc
     2041 gctcgcccga ctccttcgtc cttcccctcc gcgaactggt gaaggaaggc ggactgagcg
     2101 aagaagtcat caacgaccgc gtgcgcgaca tccttcgggt aaagttcctc atcggtctgt
     2161 tcgatgcccc ctatcagaca gaccttgccg atgccgaccg tgaagtggaa aaagaagaga
     2221 acgaagccat tgccttgcag gcatcccgcg agtccatcgt tctgctgaag aatgccggtg
     2281 aactattgcc cttagacatc aactccacca agaagattgc cgtctgtggt cccaatgcca
     2341 atgaagaagg ctacgcgctg acccattacg gcccacttgc cgtagaagtg accactgtgc
     2401 tggaaggcat tcaagaaaag acaaaaggca aggcagaggt gctctacacc aaaggctgcg
     2461 acctggtgga cgcccactgg cccgaaagtg aaatcataga ctatccgctg accgacgacg
     2521 aacaagccga gatagacaaa gccgtagaaa atgcccgtca agctgatgtt gccgtcgtag
     2581 tattgggcgg cggacaacgc acctgcggcg aaaacaaatc gcgcaccagc ctcgacctgc
     2641 ccggtcggca gttgcaactg cttcaagcca tacaagccac gggcaagccc gtcgtactga
     2701 tactcatcaa cggacgcccg ctctccatca actgggcaga caagttcgtc cccgctatcc
     2761 tcgaagcctg gtatcccggc tccaaaggcg gaacagccct ggccgacatc ctcttcggcg
     2821 actacaaccc cggtggaaag ctgacggtga ccttccccaa gaccgtaggg caaatcccct
     2881 tcaacttccc ctgcaaacct tcttcacaga tagacggcgg taagaatccg ggacctacgg
     2941 gcaacatgtc acgcatcaac ggagcactct accccttcgg ttacggcttg agctacacca
     3001 ccttcgagta ctccgacctc gacatcaccc cccgagtcat caccccgaac gagtctgcca
     3061 ccgtccgcct gaaggtgacc aacaccggca aacgtgccgg agatgaagta gtgcagctct
     3121 atatccgcga cgtactgagc agcatcacca cctacgaaaa gaatcttgca ggcttccagc
     3181 gcatccacct cgaaccgggc gaagcccagg agctgtcctt caccatcgac cgcaagcacc
     3241 tggagcttct ggacgctgac atgaaatggg tggtggaacc cggcgacttc gtgctcatgg
     3301 ccggcgcctc ttccgaagac atccgcctga acggaacgct gaccgtagaa gactaccaga
     3361 cccgtgccaa agccattgaa gcccaaaaac cagcaaagcg tgtgagtgcc agcaccaacc
     3421 cagaggatgc cgaaaacgtg ctcgacgaaa aaatcaatac cgcatggcaa ggaaataagg
     3481 gagattatat tacctttgcc ttaaagaacg gagccaaggt agataaagtt gccattgcct
     3541 ttacacgtga caacaacctg ccggcaacct tcgaaatcca gctctcgggc ggtggcggac
     3601 agttcctcac cgtatattcg ggcaccgtca gcgaatacgg caaactgatt tcctatccgt
     3661 tcaaaggcac taccgccagc gacctccgca tcgtgctgaa cgatgaccgc gtcagtattg
     3721 ccgaagttaa attttaatgt gctaatgtgc caatatgcta atgtaccaat gaccatgcag
     3781 catatacagc gcagccaatt agcacattag catattggca cattaacaca ttaaattaat
     3841 gaaaacactt cttttctgta tgctcggatt aggtttgaca gcatgtggct cttctccaaa
     3901 gggcactaac ggtgaccagg acgaactcgc catgctaata ggtacttaca cgaatggctc
     3961 aagcaagggt atctatacct tccgctttaa tcaggagacg ggaacagccg ttccgctcag
     4021 ttcagcggca ttgcccaatc cctcctacct cgtcccctcg gaagatggcg aatttgtcta
     4081 tgccgtcagt gaaatgaacg acagcacagc agccctcagc tcccttgcct tcgaccggga
     4141 aacgggagaa ctgcgcctgc tgaacaccgt tcccaccttc ggcgccgacc cctgctacgt
     4201 ggccaccaat ggccgggaag tgttgactgc caactacagc ggtggaacca tgtccgtctt
     4261 tcctttacag aaagacggca ctttggctcc tgcagacacg ctctttcaag gctctgccac
     4321 cggtcccgac gccatacggc aagccactcc ccacatccat tgcacggtct tttcaccgga
     4381 cggaaaatac atctttgcca ccgacttcag tgccgaccgc atcctgcgct ttgtgatgca
     4441 ccccgacgac cctattcctc atgcttctct ggaagccgtt gacattgaag cggattccgg
     4501 cccgcgccat ctgacattca gccctaacgg gaagtttgcc tatctcatca ccgaactgtc
     4561 cggtaaggtc attgccttca gttacgacga cggctgcctg gaacagatac agactatcac
     4621 agccgacacc gtagccgccc gtggaagtgc agacatccac ctcagtccgg atgggaaata
     4681 cctctacgcc agcaaccgtc tgaaagaaga cggcatcgcc atctttgccg tgaatcccga
     4741 aaatgggacc ttggcaaagg taggttatca gcccaccggc atccatcccc gcaacttcaa
     4801 catcacgccc aacggcaaat acttgcttgc cgcctgccgc gacagcaatg tcattcaggt
     4861 atacaaacga aacgaagtta ccggactctt ggaagatact catcaggaca ttgtagtcga
     4921 catgccggtt tgcgtacagt tcgtcagctc tgttaataat ttataaagca atatttagca
     4981 aagataactt cattaacttt gtcccttagc taaatcagtc taaacgaatg tacattatga
     5041 agaagaatat attgatgctc tcagctctgt tcttgtctat cactgccatg gcgcaaacag
     5101 acgtaaccac cggtgtgatg cgtggcaaag actacggagt gacttatatg ttgcccaaaa
     5161 cagaaataga aatcgtattg caagccacca agcataccta cactcccgga gaattttgca
     5221 gatatgccga ccgctatctg cgtctcaaca acgtgtctgc cgaacccgag gagttctgga
     5281 cactggataa gatagaaacc cgcatagccg gtgtaccgga taaggacaac gtctatttcg
     5341 tgaagatgaa agacaagacc gtagcacccc ttatggagct taccgaagac ggaattgtcc
     5401 gctccatcaa cattccgttc agcggtaagc ctgctgccaa gacgcccgaa gccaaagcca
     5461 ccgaaagcag cattgaccca cgcagttttc tgacggaaga aatactgatg tccaactcca
     5521 gtgccaagat ggccgagctg gtggccaagg aaatatacag catccgcgaa agcaagaatg
     5581 ccctcctgcg cggcgaagca gacaatatgc ccaaggacgg cgcccaactc aagctgatgc
     5641 ttgacaatct gaaccagcag gaaacggcta tgacggaaat gttctcgggc aaaataaaga
     5701 aagaacccaa gacattcacc atccggctga cgcctaaaga gatgaaagat gaggtggctt
     5761 tccgtttttc ccggaagctg ggagtggtgg ccaataatga ccttgccggt gaaccgtatt
     5821 atatcagcgt caccgacctc aaaagtcccg atgtatctgc caccgaggaa ggcaaaaaga
     5881 aagtggacgg tgtagcctat aaccttccgg gcaaggcaca agtgacattg atgtataaca
     5941 ataagaaatt gtttgacgac caacttccca ttacccaatt cggcaccgta gaatacctcg
     6001 caccggtact gttcaacaag aattctacca tcaaagtgct gtttgatacg gcaacgggag
     6061 gattgataaa agtagatagg gaataaagga attctaattc cggattgtca actggataaa
     6121 tccatcctta cgcaactgca ttacgtaggc ggtgacccgg ggaatataat tctcttcctc
     6181 cccaaagtgc ctggcaagta gagagatgat ttcgcgcacg gtacgatgtc catctatcag
     6241 attccagaca gctgtaccgt gttcttccag cctcacatgg atgtcaggag acatcccctt
     6301 cggcaataaa aaacgacgca tccattcgta tttaaaccgt gggtaggcga gtacggcgca
     6361 ctcaccttcc cattcggttg ttatatgtcc acagcggacc ggaacagcgt ccaacagact
     6421 tacttttcct tcgggtattt ccatcatacg gtatccgctt ttcctattat ttctgaatat
     6481 taggctcttc cagcttataa ccatacttct tgtctgcctt cttcagcagt agagccacta
     6541 taagggacaa gcaggcaata ccggtaaaaa tgcacatagg caccgtatag tcatacatat
     6601 tcgttccatc tggtttcttg ccggatatac aataggcatc aagcacccac cctatcaatg
     6661 taggaatacc ccaaagaccg atattctgga taaagaaaat caatgcgtat gccgtaccca
     6721 actggcttac cgggaatatc ttggccacag ccggccacat ggcagaaggt accagcgaga
     6781 aagcgatacc caaaattatc atcagcacaa tagctaccag ccaatagttt atatcgggaa
     6841 tagcataaat gaaatgcaca catatcagca tggccgagcc cagcagcatg atagatgcgg
     6901 acttgccccg cttgtcaatg aaaccaccaa agaccggagt cagaatcagc gctcccaatg
     6961 ccggaagtcc ggcaaatgta ccggccacat tctcattgat accgtatttg ataatcatca
     7021 actcggaagc aaacttctgg aatgggaata cacaagagta gaacaataca cacagcaatg
     7081 ctatcagcca gaaaccggga ttgaccagaa tattcttcac atccttaaaa gagaacttct
     7141 cttcctcatc ttccgtaccg gcagcaatgg cagcagcttc catctgtttg tccagcttct
     7201 tgtccatcac tgcaaagatg aagaaagcaa tcataccgcc caacaacaga accaaaccca
     7261 acaacaccgg tgtggaaata ccgaaagcgc gggccaaagg aatggctacg gcataaccgg
     7321 cttgcgaacc gatacgtgct aaagcgactt gtacccccat agccgtggca agctctttcc
     7381 ccttaaacca cttggctatg attttggaaa ctgtaatacc ggcgacctcc gctcctactc
     7441 caaaaatgga ataaccggca aaagcaacaa acacacccgt tttatagcca aatatttcat
     7501 tgattccgaa taaagtcgcg tcggcaccgg caagtcccgt cattgcatag tattcaagtg
     7561 ctgtaccacc taccatcagg atagttgcca gctttccggt gaaacggata ccaaagcggt
     7621 cgaggattaa tcctccccaa atcaacatca ggaaaaaaac attcagaaaa ctataaccac
     7681 cggtaaagaa tccgaaatcg gtactcgacc aagccaagtc cgtttccaac attgtcttca
     7741 acggtgctac cacgtcgttt acataataag ctaccatcat cgtgaaggca acaatcacca
     7801 atgcccccca acgggtagcc ttggaatcat tcaatttaag tttgagttgt tctgtcattg
     7861 tactatttgg atttcaattt attaatcaga ttgcataaat tgctgacaaa ggtaaataaa
     7921 tacttcatca aaacgaaaaa aggctgacac cttttcagta tcaacctttc tcttattttt
     7981 ccaagcggga gtcatccgca atatccttat cttattctgc tgcaggggct tctgctgcag
     8041 gagcaggagt ttcagccgga gttgtagctg caggggcctc cgattgcgga gcttctgtac
     8101 ctacgggcat gttataagga ttagtttttt cttcttgttg cgcctgttcc agaatcacat
     8161 caccgccctt gcctgtggaa gaaggaatag tgtaagcaga aacaatactg aagactacca
     8221 tgacagctgc cagagtccag gttgcttttt ccaaaaagtc cgtagtcttg cgcacaccca
     8281 taatttggtt ggatgatgaa aagcctgatg ccagaccacc tcctttagaa ttttgaatca
     8341 atacaatgaa gcacatcagc acagatgcaa tcagcattaa gataactaat aataaataca
     8401 ttttgttatt ttgatttagc gttaataatc aatttctcca aaaatctgat ttggtctgca
     8461 aagtaagcat ttttttttgg ataattcaaa cttaattttt taataatttc aagcgccttg
     8521 tcatatcggt gctgttttat atagattttg gctaaagttt ccgtaaaaca gctatcgtcc
     8581 aactcttccg ttaccggcga tactgagggt tcttcctctt cttcagtctc ttcctccttc
     8641 tctacaagaa actcccttct cgtatccgag gcatccgaag actcactctt ttggataaag
     8701 tcatctatca attcatgccc gcgcagttta ggcacttccg actcatcttc tgcatccaca
     8761 ccgggttctt cctgcattaa ataggccgta taatccaccg cataatccag ctccgtatgc
     8821 tgtgaatgct cttcgggaac agtagccaga aatgcgtcaa tcaaggaaag ggtacggtcc
     8881 acactcggct ctttctccaa atcgccggaa aacagcgacg agaccttccg ggatttcaaa
     8941 gtatagcggt caccctctat aaagtaaaac agcacacgac ggtctgccac atacaacaca
     9001 gccttgcgca actccgcgcc aaagttgatg tcgtgcagca gatagaggtt tttcagatag
     9061 agcaaacgga gcgactggaa ataaggatag cgtgccacca atgtgcgaag ctcgtacaaa
     9121 gtatccctat tcagcgtctc gggatgctga atccattgtt gcaaatgggt aggcgtcatg
     9181 agtttaccag ttagctacag ttgcattgaa aatctgttcg gcaatgtctt tcaccatcaa
     9241 ggttatcagc tggtcctgca cttcggtcag caattttgag gaatcatagg tctggaaagc
     9301 cgagaactgc tgttcaaagt cctcctcatg gttcgtgtta ttggtgtagc gcacgttgac
     9361 agtcagcgtc accttcacct tcgaagagta gccgctggca tccaccgatt cattatattg
     9421 attgtagccg gttatttctc cgtctatttc caggtctcct ccggaattca ccagttgcag
     9481 gcgagtctgc tgaatgaaca tatccttcat tttctggtta aattctgttg ccagcggtgc
     9541 atatacatac tctgcccggt tctggaaatc ggcaatggaa atcgttttta cctttgtata
     9601 gtcgatagag cttatcggag caagtcccaa cttcatacta catgaattca ccagaaataa
     9661 caagcttacc aacaaggaag caaatgccgc ttttttaatc caatccatat tcttttatct
     9721 ttctgtataa cgtacgctca gagatattca aatcctgagc cgcactctta cgcttgccgt
     9781 gatgtttttc aagcgcctta cgtatcattt ctttctccac ttcatccagg gagagtgact
     9841 cctccacata ttcttccgta tcctggaaat catcgtccac cggagtaacc ggctttaccg
     9901 aaggatgtat aatggtgggg acactggatg ttaccggagg taccaccgcc ggagtagccg
     9961 gcgtatagta ggccgatgtg gcaaccgccg gattggctac cgttcccctt tcagccataa
    10021 tctcatgcac caactttttc aagtccgtta catcctggcg catatcaaac agaacctggt
    10081 agagaatttc ccgttcactc ccaaagctct tgtcctcctt cactccaaac aaggcaggca
    10141 ggcgctgcat attgttctgc tcaggcagat agcccttcag tatggatgca ttgatttcac
    10201 gattggtctc aatgatggat atctgctcgg tgatattctt caactggcgc acattacccg
    10261 gccatgagta gcccagcaac acttgcttgc cgtcttccgt cagctgaatg gcaggcatac
    10321 ggtacttttc tgcaaagtcc gaagcaaact ttcggaacag cagcaccacg tcttcaccgc
    10381 gttcgcgcaa tggagggacc tgaataggaa ctgtgttcaa acggtaatac aagtcttcac
    10441 gaaaacgtcc gtcagcaatg gcttgtgtca agtttacatt ggtagcggca acaatacgca
    10501 catcggtctt ttccacctta gaagaaccta ctttgatgaa ttcaccgctc tcgagcacac
    10561 gcaacaagcg tgcctgggta ggcaaaggca attcgccgac ttcatcaagg aagattgttc
    10621 cgccgttggc ctcaccgaaa taccccttcc gttcgccgat agccccggta aatgcgccct
    10681 tctcatgacc gaacagttcc gagtcaatcg tcccttcggg aatggctcca cagttcacgg
    10741 caatgtactg tccatgcttg cgccggctgt actggtgtat tatctgcgga aagctctcct
    10801 ttcccacacc actctctccg gtaatcagta cagacaagtc ggtgggcgct acctggatag
    10861 cgatatcaat ggcacgcatc agcgcttcat tgttgccgat aatgccgaaa cgtaatttta
    10921 cttgttgtat ttccgctttt gtcattctac aaatcttctt ctacactatc gagtttcagt
    10981 ttgtcgctat cgtcacgttt ctcgtaatat tgcttgcgca gcggatttgc atgtgcctct
    11041 ttctcacgct ggcggttacg gaacacatct attgccacat agatagcctg ccggaatgaa
    11101 tcttcagagg cgattccttt cccggcaata tcgtaggccg tgccatgagc aggcgaagtg
    11161 cgtatcaccg gcaagccggc agtatagttc acgccctcgt ccatagccaa tgccttgaac
    11221 ggtgccagcc cctggtcgtg atacatggcc aggataccat caaaatgggt aaagttatct
    11281 gagcccataa acccgtctgc cggataagga ccatagcaaa gcataccctt agcagccatt
    11341 tcgttgatgg ccggaatgat aatctcctgc tcttcagttc ccagcaatcc gccgtctcct
    11401 gcatgcggat tcagcgaaag cactgcaata cgcggtgcgc tgatagcaaa atcctgcttc
    11461 aaggagcggt tgaatatctt cagtttttct tgtatcagtt ctttggtgat gcttccggct
    11521 atctctttaa cgggaatatg tccggtcacc aatgctaccc ggaagtcatc tttcatcaga
    11581 atcataaggg ccttctcgcc atctcccaat ttttgctcta tatactccgt atgtccgggg
    11641 aaggcaaact cctccgactg gatggtatgc ttgttgatgg gagctgtgac aatcacgtct
    11701 atcattccct ccttatattc ctcaatggct ttttccagtg caccaagtgc agctttacca
    11761 gcttcaacgt caggtttaga gaactcaacc tttacttcat catccgtaca gttcactaca
    11821 ctcaagcgat tgggaaccgc ttcggaggcg gagttgacga tactgaagtt ggtaggcaag
    11881 tccaatgatt tacgatgata agctgccact ttaggcgaac cgtagataat cggcgtgcac
    11941 aattccagca tcaccgggtc tgcaaacgtc tttaaaatca cttcataccc tacaccatta
    12001 atgtcgcctt gtgtaatgcc gactcttatt ttgttgtctt ccatttttat tacttattat
    12061 tagtagtatc ttttgaggtt acgcctaccg gaatttccgt accttcctgc ttgctgccgg
    12121 gcagtttcaa ggtatagagc gaagcctcca tctgacgtac cagattacgt ttcattttat
    12181 caggtgaata aataaatatt tcagatacga taatacgctg attggccttg tccaaacgta
    12241 catgcgatac gaacggaccg cccatgaagt caccctttat gcgccacaag ccgcgggcct
    12301 ccagtgcata gtctccctgc acactgatgg ggcgtacatc ggtcatcaga gaatccgtcg
    12361 acatatacat gccttcacgg gcaccaggga tattaacctt catcacggaa tcgcgtttat
    12421 gaacaaaata ttctttagta aacgtatcct tatccgtata aggataagag tagattacaa
    12481 agttctggtc gccggtagct gcattcgtac ctgcccagaa gaagttctca ccctccttgg
    12541 tagatgtcag ttcgcccggc acccatacat cgcaatcgaa ctggcttttc accttcgttg
    12601 ctatatagtc gctatgcttg tccttcaata ctgaaatctg acgattcatt tccgcatggg
    12661 taaagaaatc gatgattacc tgcctgttct cctccacaaa tttctcgaac gaagcctcgt
    12721 ccggtgcctg aatagtgaga atagactgag gagcagcata tacattcctt gcatacttga
    12781 atttaggctg ggtatagagg tccttgttca catcgacaat aatgatattg cgaatcagtt
    12841 ttaaagtggc atcataattg gaaggggcag tatacatgat tcggaatgaa cgttctgact
    12901 ggggaagccc cggaacatca gaatcaagca catcgaaaag cgccctaccg gcaggacgtt
    12961 cccacaagcc gggctccacc actaccagaa cttcatacgc acgaccgctg gaggtcggag
    13021 taaacacacc ctttttacca ccaccgcaag cggaaaaaag tgtcagtacg agaaccatac
    13081 ttaaataaaa caagtgcttt ctcatatctc tatcatttta gtttttcaca aagctacgaa
    13141 gaatgcgtaa tatcctccct acctaagtta ataatttata ttaattcttc tttattctcc
    13201 tcctgcttgg cagtggacaa catgccacaa gcggcaaata tatcctctcc acgcgatgac
    13261 cgtatagtgg taaacagacc gtgcgaagtc agataatcac ggaacgcagt catggtttcc
    13321 atatcagccc cttcaagatt cactccaggt atggcatgaa aacgaatcag gttaatccgg
    13381 cagtccagcc cgcgtagcaa cttcagaagt tcctttgcat acggtaacga gtcattcact
    13441 cctttgaaaa caatatattc aaaagatagt ctgcgctgtt tgctaaaatc atagtttctt
    13501 aacaattcaa caatctccgt gatggagaag gccttctctg ccggcatcag ctcgcgacgt
    13561 tgcaaaggta tcggcgaatg aaggctgata gccagatggc agtccgactc ctcaataaaa
    13621 cgctgcaagc ccttcttcaa tcccacagaa gaaagtgtaa cacgcttggg actccacgca
    13681 tacccatatg aggcggtcat tatttccagc gctttcaata cctcgtccag attatcaagt
    13741 ggttcaccca tgcccatcat taccacattg gtaagcttgt ccctttcggg caacgaattg
    13801 atttgattaa taatctggtt ggatgtcaga ttggcagtaa aaccttgttt gccggtcata
    13861 cagaacttgc aattcatctt acagcccacc tgcgaggaga cacaaagcgt agccctgtct
    13921 tcgtcgggta tatagacagc ttccacgaaa tgcccctctc ctgcccgata caagtatttc
    13981 accgtaccgt ctacagagcg catggcatct accggtgctt cggcacctac ctcatagatt
    14041 tctttcagca attcccgatg ctttaacgaa agattgctca tttcgtctat agaagtcacc
    14101 ttcttgccat acagccagga agctatctgc ttggcagaga aaccgggcat tcccagattc
    14161 ttcaccacat tctgcaattc agagagcgtc aagcccaata gaggtcgttt ctgcatatcg
    14221 tttttcatta aaaacaaaac tctttcaaga atgcaaaggt aggaataaag ttgcacaaag
    14281 acaacggaga gtatagaaaa tgaaatgtac agagaatgaa aaagccgccc gggagtaccg
    14341 gacggctttt caatatgggt tttctattct tagaagaata aataacgttg gtcttttacg
    14401 ttggctttca gatacaagtc actgatgaac tggcttgcca tgcgtgcgtg catgttagcc
    14461 aagttagcct cttcagtttc cttgttgaat gtttcgttca atttctcttt tgcataaggt
    14521 tgcagaacga atacaccacc attacccttg ataggagcac tcagcttgtt cacttcggca
    14581 atagaagcgt atgcgcctac cagaggttcg ctgctacgca atgccgggat ataggcagga
    14641 gcagagaaag taacgtgctt tacagaatca ctgacagcat ttgccatatt cttgtactgc
    14701 tcgaacgaag ttgcattggc agccttcata tcagccataa tcttctctgc tttcttgtca
    14761 cggagaattt cagctctcaa ctggtccttt accaaagcca gtgggcgata accttcagga
    14821 acaatacttg caacacctac taccagcata cggtcgctct cgccacattc gtacaaaccg
    14881 gaaacttcac cggcctttgc ctcaaacgcc catttcaaag catctttggt acctctgata
    14941 ccaccgatac catgttcaga gctgtacaag tcggctctat ccaacaactt ataaccggca
    15001 tcttccgcat tggcaatcat tttctctaaa gtattgtttg cagcgataaa ctggctgaat
    15061 tcattgtatg ccttgctgta agtttcctta ctgaattcta ccggacgctt gataacggct
    15121 accttatatt tatccttgac agccttcttg ttggttacct gcaaaatgac atttgcttgt
    15181 cccaacgcca gattggtcag ttcgttctgt cccaaagtag tgacagcagt aatatatttc
    15241 aagttgtcac cgtcaatctg tgcgccttcg tagttagctg aagagatcca ggtaggctca
    15301 ccggtctgac cgtacttctt cgcaatttca gcaaagctgg caccaccctt aatagcattg
    15361 tagatgctgt cggctaaagt cttcgtcttt tcagcatctt cggcaactac ctgaatctga
    15421 cggaactcga tagagtccgg catagcagca gtagccaatt tcttgaaaga gttaagagta
    15481 ttgtccgata cgttataata aggtccgaat acaccaccca ccgcaacaga gtccaaacgg
    15541 gctgtcacat cagcaggcag agacttagta gtgtagaaca agtctgtata aggagcttcg
    15601 gaaccggtag aacggataaa ggtagtatag tcagaaggat tggcagtaag ttgttcagtg
    15661 tattcttcca tttccttctg gagagcagct ctgtcttctg cacttgcagt aacttgcaca
    15721 tcaatgaact tgatattgcg agtttccaca tattgcttga actgttcttt cttcttgtcg
    15781 tatgcagcct tcaaatcaga atccttgata acgatggtag agtcaacgat agaagaatag
    15841 ggaactgcag caagcagcag gtctgactgc tctactcttg catcaaaagc gtcctgagct
    15901 tctaccgggt tggagaaaag ggattttgta atcaaagctt gatacttctc ctgaagacgt
    15961 gcctggataa gggacttttc gaggaaagac cagaacttgt acatggattc atagtattct
    16021 gcatattgtg aaggcatctg tgccttattc atttttgaat agtccaccaa gaacttcttc
    16081 aacatatcct tatcaaacgc accggtctga ggattacgga acggagtctg ttgcagcatc
    16141 ggatgcacac cggcattaat gatagcctga atctcagcct tcgatacaac cagaccgagt
    16201 ttctttgctt ccttttcaat cagcttatta ttgacgtatg ttctccatac ttcatctttg
    16261 atttggtttg tctgctcatc gctcaatgca ctgttgccac tggagaactt gatgacttct
    16321 gtatattctt ctaccaatgc ttgaaaatcc tgagcggaaa ttgattcccc gttcacttca
    16381 cctacgtctt gtgactggtg tggctgaagc actttccacg cgtcacctgc gatgaaagca
    16441 aacagcg
//
