LOCUS       gnlProkkaICOGMFEM_68   13372 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ICOGMFEM_68.
ACCESSION   gnlProkkaICOGMFEM_68
VERSION     gnlProkkaICOGMFEM_68
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 05:25:50
            Original ID  :: gnl|Prokka|ICOGMFEM_68
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 13372
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..735
                     /locus_tag="ctg68_1"
                     /transl_table=11
                     /translation="MRDKIISKYEGHIPCELVFQSIDDLPEGFTCPEGRTKPWGTNHAV
                     MMGADVIKEPFAVINCDDFYGRDSFQVMGKFLAALPEGSKNVYSMVGFRIGNTLSESGT
                     VSRGLCGTDANNLLTSVVERTKIQRMDGEVKYIDDNGEWTATPETTPVSMNFWGFTPDY
                     FAYSAEFFKSFLSDPKNMENLKSEFFIPLMVDKLINDGTATCEVLDTTSKWFGVTYPED
                     RQSVVDKIQALVDAGEYPAKLF"
     protocluster    1..13372
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[3644:3911]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      3645..3911
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..13372
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..13372
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             complement(780..2450)
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 276.2; E-value:
                     9.7e-84)"
                     /gene_kind="transport"
                     /locus_tag="ctg68_2"
                     /transl_table=11
                     /translation="MKKQQKDKKVKKDRREKLRYIREVSAEQRGRILLSCLTGILGVAF
                     ALAFIYATKRVIDTATGITDDNLTHIAVLTVVLLTAQLLCGAADTWISTRMQIETGNAL
                     RHRLFSRLLQSRWNELERFHTGDVVNRVEQDTAAIVTLLTSSVPAFIVTSIQLLAAFLF
                     FYFLDPSLPWLIVAILPVFLLGSRFYMRRMKRYTHDIRNSDGRIQSVIQESLQHRIVIK
                     TLEQGERHLDKLDDLQDMLHSQVMGRTRFSLSAHMLVALAFSGGYLTAFLWGAVHLSAG
                     CITFGTMTAFLQLVGKVQRPVLDLSRLIPSVVNALTAIDRLLELERLPAEADGDSIFLA
                     STPELELKDVTFGYTPDDRPVFSRFSCRFPAGSCIAVVGETGKGKTTLIRLLLALATPQ
                     EGQILLIPAKHPLETNHTVSPQTRKNFVYVPQGNTLFSGTIRDNLLMGNPQASEEAIYQ
                     ALQTATADFVFHLPDGVDSPLSERGGGLSEGQAQRIAIARALLRPGNILLLDEATSALD
                     PDTERLLIKNLRRDCAGKTCIFVTHHPAVAEACESIVRL"
     CDS             complement(2473..3636)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_5"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_3"
                     /sec_met_domain="NTP_transf_5 (E-value: 9.8e-47, bitscore:
                     149.3, seeds: 77, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQHAFFSLVRSGLWGTPADRQLFRSVSPDDWETVYRMANSQALLA
                     LTFDGISSLPAELRPPRALYLKWAARTAQIEQANKRLNQLLPELNTLYREAGLHPVLLK
                     GQGIGTNYRTPLHRQCGDIDIYLGKQGQPIANRLLLQQGAIVEGEASDKHASYSLKGVH
                     IENHRIILRLNSPLANRHFQQIIRKWYPQETDYALFSETGKEDSKAVSIAIPPATFNAL
                     YIFLHAFVHFLNSGIGLRQLCDWTCLLANRHKEIDATTLLRQLQDLGLLHAAQAFGYIA
                     VTRLGLPANRLPFPLEGTKQIGEQLLEDILSTGNFGQHDNRIKPRPKGYWAGKWYTFCR
                     ATRRCNELRQFAPYEALWYPVTLIGGTIAIQINRLKGVKDKKARTKK"
     CDS             complement(3645..3911)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: Stand_Alone_Lasso_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_4"
                     /sec_met_domain="Stand_Alone_Lasso_RRE (E-value: 1e-13,
                     bitscore: 41.0, seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="PF05402 (E-value: 4.8e-16, bitscore: 48.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKIKQGFILHRIGDDYIIMQDGSSNVDFSKVISLNQTSAMLWQEI
                     ENKEFDTDSVTEALTSRYDVDNESARRDAQKFIDSLDREGIIE"
     CDS             complement(3924..4364)
                     /locus_tag="ctg68_5"
                     /transl_table=11
                     /translation="MKKSIPNEILLPEVARLIKEGHTVTITVRGNSMNPFLVDRRDRVT
                     LGDFTTEQLQPGVAVLARDLTERIVFHRIIRRNGNILILQGDGNLAQTEETDIGRVMGV
                     MTEAMRKDKRYTADGKVWKLYSYWWMKLNPARRWLLALFRRI"
     CDS             complement(4391..5317)
                     /locus_tag="ctg68_6"
                     /transl_table=11
                     /translation="MRIQILDYQVGPHTFRMVKPSDFNIFKALPSLIPFITTIDTTQKV
                     IFETEIDDDETATKRTIAKTPDDICFNWEDADCIIRPLPHSSHLVSITPRKSGKNYWME
                     CNDNFRQCFIHLPACRTETPAPENETNFVLNNFLMMLYAFNAARHHTLLMHASVVATET
                     GKGYLFLGKSGTGKSTHTGLWLQQFSDCHLLNDDNPIVHVDSLGKQATVFGSPWSGKTP
                     CYRKESMTVGAFVRLEQAPQNEIEQERAAHAFATLLPSCSCLKQNKEIYNAIVTTVTEL
                     ATLAPVYHLKCLPDREATELCRKTVEG"
     CDS             complement(5564..9142)
                     /locus_tag="ctg68_7"
                     /transl_table=11
                     /translation="MMKLRNLMQVACMATAALTAFSCSQEEFENSGWKGNITVNATFEG
                     AGTDTRTTVNDEYKILWQDTDALGLFCSNAESNYSNTKLEYASGAGQTSATFNGSKPSG
                     ETAVFSIYPYQQNMSVSGNTLTMTLPATLTNYNGSSNGPMYAKVTNPDNLSALSFKHMA
                     AMIKLTVNKIPAEATTFKIIASNNIAGTCTVDLTAADPILAVTSDESKEITASFTASAD
                     IKSRNFYIPLPTGTYSSITAQLTNGSDKVYFTKTLNDKILGRRDILVVPPLDCVVVEAT
                     TPSALSTALADSKNLPQEAPTAATVTDIAVSGSFNTTSGSNDGIAIPVLQNSDINLAFN
                     TAPTTSTSAPLKLTDKTNTSVSTPAATATNSVSLAVPETTAEQEAPSVAITMPSTTVTL
                     AAVGNKATYNEVTATTAQQTLIINAGVTVKKLTVKGGNLKIYGKVEQLVHDAGNTTIYI
                     IKGTEASLPATIDSKFVVQSDVAVLKTAFANGEDFKLSADADITGQSVSVPAGKSVVLD
                     LNGYTLTADNSATGKIIVLGKMTLKDSSTEKKGKIVASQDYTAASYNGSLIEIAGEDAS
                     MTMESGNISAVRKTPNSNGQYGVGVTDGGDFTMTGGKIEAGWFAVAGNGNYKTQNSIIN
                     ITDGELISTADYAVYLPQSGTTTISGGKVYGAAGGVCIQRGTLNVEGTALITSKGTGST
                     GNWGDGTGGLDCAAINVSGAYGIATVNIKGGTLIAEAKSLITEGTTYTPVINVTGGTFS
                     DPSALKYMKTNANVNIKLTADKTCPGFKTTSGQTLTMDLGGKILTLADPTVGSTGTETN
                     SCQLLEGSNVTFKNGTLKSDNNKIMIQNYCNLTLDNMTVEDTNAQYVVSNNCGNISINN
                     TTINAGSNANQFAFDVCGYAKYTAGVTVTVSGTSVINGKVEISKSAGNTEPMKLNITGG
                     TFNGDLKVDASVGTENAKSIISVSGGTFSDPSVLKYMATNATVDIKLLSNINIAKTELA
                     TGYILNAANATANLNLNGHDIINSSETADATPFTQIFTVQNGTLNISGNGNVKCDASAT
                     AKDDGYRMVIEARGHGTVNIHGGSYYNTQKLNTQIDLIYARENGKINIYGGTFESGKYG
                     TPNNDTDGRYWVLNLKNTDKNTASIQVSGGTFINFNPANPNMDDNESYLVTGYEVTRDG
                     SVYTAAHKVNDGRKEYIVGPTSQENR"
     CDS             complement(9156..9371)
                     /locus_tag="ctg68_8"
                     /transl_table=11
                     /translation="MKQNTPDGREAYITPSIEVIKMENEGVIATSGEPYHPITRSYSGS
                     TSTHSYNSASSSDLEDLINDILTVEN"
     CDS             9420..9593
                     /locus_tag="ctg68_9"
                     /transl_table=11
                     /translation="MFVYPLFRPSHCPFPGYTTVTHVVCVYTIPPDGRKPYKHRREHPC
                     CYLQGNFQSCEV"
     CDS             complement(9737..10063)
                     /locus_tag="ctg68_10"
                     /transl_table=11
                     /translation="MKNCYGIDFRSWHKELRTREKTKQPPCKLPDRASRSLQGVLFKVY
                     QISVLILLKKILFSFFSVCLPLFIRHIAAMLLRKTSSKTMQTVTKYLKELSGVRSDNSP
                     NSYK"
     CDS             10929..11261
                     /locus_tag="ctg68_11"
                     /transl_table=11
                     /translation="MKQLIACCGLDCENCAARIATVNNDDELREKTAKEWSVLNNTPEI
                     TAETIHCMGCRADGVKFTYCSDYCAIRKCVYEKGFNTCGDCKELDTCQVVGAVLQHAPG
                     ARENLY"
     CDS             11496..12272
                     /NRPS_PKS="Domain: oMT (51-145). E-value: 2e-11. Score:
                     34.4. Matches aSDomain: nrpspksdomains_ctg68_12_oMT.1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 81.3; E-value:
                     1.3e-24)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg68_12"
                     /transl_table=11
                     /translation="MSNENKTIHDFEFNLICDFFSNMERQGPGSPEVTLKALSFVDGLT
                     DESLIADIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQDRVKGIVGS
                     MDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGYIAVSESSWFTDERPAEIN
                     DFWMDAYSEMDTLPNQVTKLYKAGYLPVATFILPENCWTEHYFASKVAAQEIFRKKYAG
                     NKIAEEFSLLQMIEDELYGKYKEFYGYVFFIAKKVG"
     aSDomain        11649..11930
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg68_12_oMT.1"
                     /domain_subtypes="oMT"
                     /evalue="2.00E-11"
                     /label="ctg68_12_oMT.1"
                     /locus_tag="ctg68_12"
                     /protein_end="145"
                     /protein_start="51"
                     /score="34.4"
                     /tool="antismash"
                     /translation="DIGCGTGGQTMVLAGHVPGQITGIDLFPGFIDIFNRNARQLGLQD
                     RVKGIVGSMDALPFGEEELDMIWCEGAIYNIGFERGLKEWRKYLKPGGY"
     CDS             complement(12347..13195)
                     /locus_tag="ctg68_13"
                     /transl_table=11
                     /translation="MNISEFNINDEFIACNHITTNELNPLVEKPYHTKASIFALCTKGV
                     LKTIINHTQFRVEANALLVIPPETFVQLLHTSDDAEIYVVIFSQQLIQSSGAGKVMMDK
                     FHIIGKHYIFPLSRTDFQLYAEFMTYLSHLYQRTESPSSLVSLQTLLTYLLQGISELCP
                     ERPRIKETPGSRHFNQYRIFIRLVHTDYVREHQVSYYALKMNMRPAALCRLVKKESGYT
                     AMEIINNTIIMDAKAQLCTANTPIKDIAVSLGFNNAAFFNKFFKRHTGIPPQKFRTSSK
                     Q"
ORIGIN
        1 ttccgcgaca agattatttc caaatacgaa ggccatattc cgtgcgaact ggtattccag
       61 tccattgatg accttcccga aggcttcact tgccccgaag gccgtaccaa accttgggga
      121 accaaccatg ctgtaatgat gggtgccgat gtaataaagg aaccgtttgc tgttatcaac
      181 tgcgacgatt tctacggtcg tgattccttc caggtaatgg gtaaatttct tgcagccctt
      241 cccgaaggct ccaaaaacgt atattccatg gtaggcttcc gcatcggcaa cacgttgagc
      301 gaaagcggta ccgtatcccg tggattgtgc ggaacggatg cgaacaacct gctgacttcc
      361 gtagtggaac gcaccaagat tcagcgcatg gacggtgagg tgaaatacat cgatgataac
      421 ggtgaatgga ctgccactcc cgagacgact ccggtcagca tgaacttctg gggtttcact
      481 cccgattact ttgcttacag tgcagagttt ttcaagagtt tcttgagcga cccgaagaac
      541 atggagaacc tgaagagcga attcttcatc ccgctgatgg tggataagct gattaacgat
      601 ggcactgcta cctgcgaagt gctcgacaca accagcaagt ggttcggtgt gacttatccc
      661 gaagaccgtc agagtgtagt cgacaagatt caggctttgg tggatgcagg cgagtatcct
      721 gcaaagctgt tctgagtttg ttaaccaaag gcagataccc gttggggctc attctctgat
      781 tataatcgga caatagattc gcatgcctcc gctactgccg gatggtgggt gacgaagata
      841 catgttttgc ctgcgcagtc tctgcgcagg ttttttatta acagccgttc cgtgtcgggg
      901 tcgagggcag aagtggcttc atctaaaaga agaatgtttc cggggcgtag cagagcgcgg
      961 gcaatggcga tgcgttgggc ttgtccttca ctgagtccgc cacctcgttc gctgagtggg
     1021 gagtctacgc cgtcgggaag gtggaagacg aagtcggcgg tggcggtttg cagggcttga
     1081 tatatggctt cttcagaagc ttgtgggttt cccatcagca ggttgtcacg gatagttccg
     1141 ctgaaaaggg tattgccttg cgggacatat acgaagttct tgcgggtttg cggagagacg
     1201 gtatgattgg tttcaagtgg atgtttggcg ggtatcaaga gtatctgtcc ctcttgtggc
     1261 gttgccagtg ccaacaatag ccggatgagc gttgtctttc cttttcctgt ttctccgact
     1321 acagctatgc agctaccggc ggggaaacgg caggagaagc ggctgaatac cggacggtca
     1381 tcgggagtgt agccaaaagt cacgtctttc agttccagtt ccggggtaga ggcgaggaat
     1441 atgctgtcac cgtccgcttc tgccggcagt ctttccaatt ccaatagccg gtctatggcg
     1501 gtaagggcat tgactacgga aggtatcagg cgtgagaggt cgagcacggg acgctggact
     1561 tttcctacca attgcaaaaa ggcggtcatc gttccgaagg tgatacagcc tgcgctgagg
     1621 tgaacggctc cccaaagaaa agccgtgagg tatccgccgg aaaaggcaag ggccactaac
     1681 atgtgggcgg aaagcgagaa acgggtacgt cccatgactt ggctgtggag catgtcttgc
     1741 aagtcatcga gtttgtccag atgccgttcg ccttgttcca atgttttaat cactatgcga
     1801 tgttgcaggc tctcttgtat gacggactgg atgcgaccgt cactgttccg aatatcatgt
     1861 gtatagcgtt tcattcgtcg catatagaaa cggctgccta atagaaagac gggcaggatg
     1921 gcaacaatca gccatggcag tgaagggtct aaaaagtaga agaatagaaa ggctgccagc
     1981 agttgtatac tcgtgacgat gaatgccggg acagaagagg tgagcaatgt gacgatggcg
     2041 gcggtgtctt gttctacccg gttcactacg tctccggtat ggaaacgctc caattcgttc
     2101 cagcggcttt gcagtaagcg cgagaagagg cggtggcgaa gggcgttgcc cgtctctatc
     2161 tgcatacggg tacttatcca agtgtcagca gctccgcaca gtaattgggc agtcagcagg
     2221 acaacggtga gaacggcgat atgcgtcagg ttgtcgtctg ttattccggt agcggtgtct
     2281 atcacccgtt tggttgcata gataaaggct agggcaaagg ccacgcccag aatgccggtg
     2341 aggcaactta gcaggatacg tccgcgttgt tcggcagata cctctcgaat atacctaagt
     2401 ttttcacgtc tgtccttttt cacttttttg tccttctgtt gctttttcat tccttttatt
     2461 ttccgggttc ttttatttct ttgtccttgc tttcttgtct tttactcctt ttaatcggtt
     2521 tatttgtata gctatcgttc cccctatcag agtcacggga taccagagtg cttcgtacgg
     2581 tgcaaattga cgcagttcgt tgcagcgtcg ggtggcgcgg cagaaggtgt accactttcc
     2641 tgcccaatat cctttggggc gtggcttgat gcggttatca tgttgcccga agttaccggt
     2701 agacaggatg tcttccaata attgttctcc tatctgcttg gtgccttcca aggggaaagg
     2761 aagccggttg gcgggcaatc ccagtcgggt gacggcaatg tagccgaatg cttgtgcggc
     2821 atgcaatagt ccgaggtcct gcaactggcg aagcagggtg gtggcatcta tttctttgtg
     2881 gcgattggca agcagacaag tccagtcgca tagctggcgc aggccgattc cgctgttcag
     2941 gaaatgtaca aaggcatgta ggaagatata aagtgcattg aaggtggccg gaggtatggc
     3001 gatactgacg gccttcgagt cctctttccc ggtttcggag aatagggcat agtctgtttc
     3061 ctgcggatac cattttctga taatctgctg aaagtgccgg ttggcaagcg gactgttcag
     3121 ccggaggatg atgcggtggt tctcgatgtg tactcctttc aaactgtagc tggcatgctt
     3181 gtcggacgct tctccctcga ctatggcgcc ttgttgcagc aggaggcggt tggctatggg
     3241 ttgtccttgt tttcctaaat agatgtcgat gtctccgcat tgccggtgca agggagtgcg
     3301 gtagttggtg ccgatgcctt gccctttcag cagtacggga tgcagcccgg cttcccggta
     3361 aagggtattg agttcgggca gaagctggtt gaggcgtttg ttggcttgtt ctatctgtgc
     3421 agtccgggca gcccatttca gatagagggc gcgtggaggg cgcagttcgg ccggtagact
     3481 gcttatgccg tcaaaagtca gtgcaagcag ggcttgtgag tttgccatgc ggtacacggt
     3541 ttcccagtcg tccggcgaga ccgaccggaa gagttgtcgg tctgccggag tgccccacag
     3601 gccggagcgt accaatgaaa agaaagcgtg ttgcatatcc gtccttattc tatgattcct
     3661 tcgcggtcaa gggagtcgat aaacttctgc gcatcgcgac gggccgattc gttatctaca
     3721 tcatagcggc tggtcagggc ttctgtcacg ctgtctgtat cgaactcttt gttttctatc
     3781 tcttgccaaa gcatggcgga agtttggttc aggctgatga ctttgctgaa gtccacgttc
     3841 gacgagccgt cttgcatgat gatgtagtca tcgcctatcc ggtgcaggat aaatccttgt
     3901 ttgattttca tggttatttt gttttatatt cttctgaaca gggcgagcag ccagcggcga
     3961 gcagggttta gcttcatcca ccagtaggag tagagcttcc agactttgcc gtcggcggtg
     4021 taccgtttgt cttttcgcat ggcttcggtc atgacgccca ttacccgtcc gatgtcggtt
     4081 tcttcggtct gggcgaggtt gccatcgcct tgcaggatga gtatatttcc gttccgacgg
     4141 atgatgcggt gaaagacgat gcgttccgtc aggtcgcgtg ccagtacggc gacgcccggt
     4201 tgcagctgtt ctgtggtgaa atcgcccagt gtcacccggt cacggcggtc cactaagaaa
     4261 ggattcatgc tgttgccccg cacggtgatg gttactgtat gcccctcttt gatgagacgc
     4321 gccacttcgg gaagcaatat ctcgttggga atgcttttct tcatcggctg ttcagttcat
     4381 cattcataac ttatccttct accgtctttc tgcaaagctc cgtcgcttca cggtcgggca
     4441 ggcatttcag atgatagacg ggtgccagcg tggcaagttc cgtcacagtg gtgacaatgg
     4501 cgttatagat ttccttgttc tgcttcaggc aagagcagga ggggaggagg gtggcgaaag
     4561 catgtgctgc tctctcttgc tctatttcat tctgcggtgc ttgttccaag cggacgaagg
     4621 cgcctacggt catggattct ttccgatagc atggtgtctt tccgctccac ggagaaccga
     4681 aaacagtggc ttgcttgccg aggctgtcca catgtactat cggattgtca tcgttcagta
     4741 gatggcagtc cgagaactgt tgcagccaga gcccggtgtg cgtacttttg cccgtgccgc
     4801 ttttccctaa gaagaggtag cctttgcctg tttcagtagc gacaaccgag gcatgcatca
     4861 gcagtgtatg gtggcgggcg gcattgaagg catagagcat catcaagaag ttgttcagta
     4921 cgaagttcgt ttcgttttcc ggagccggtg tttctgtcct gcaggccggt aggtggatga
     4981 agcattgcct gaagttatcg ttgcactcca tccaatagtt tttcccgctt ttccgtgggg
     5041 tgatggatac aaggtgtgag ctgtggggca aagggcgaat gatgcaatcg gcatcttccc
     5101 agttgaaaca tatatcatcg ggagttttcg ctatggttcg ttttgtcgct gtttcgtcat
     5161 cgtctatctc tgtttcaaag attacttttt gcgtcgtgtc tattgtcgtg atgaacggaa
     5221 tcagtgaagg caacgccttg aatatattga agtcggaagg tttcaccatg cggaaggtgt
     5281 gcggtcctac ttgataatcc aatatctgta ttctcatatg ttttgattgt tagttgttat
     5341 tcatgatact ttgggctact cagaaaaata atgaatgttt gtgtgaatga ggaagatttg
     5401 agagattttt caactgtctt gttgtcattt tttagacgcg gaggacgcag atttataaaa
     5461 gaaaatccgc tgtccgccgc atctaaaaga tagtaataag gcgattccga tacctcttcg
     5521 tttggtctgc gaggatatat tgcttccttt cttagaattt ggcttatcgg ttctcctgac
     5581 ttgttgggcc aacaatatat tctttcctcc catcgttgac tttgtgggct gctgtatata
     5641 cactgccgtc acgggtaacc tcgtaacctg ttaccaaata ggattcattg tcgtccatat
     5701 tcggatttgc cgggttgaaa ttgatgaacg ttccaccgga cacctggatg ctggcagtgt
     5761 tcttgtctgt attctttaag ttcagtaccc agtatctgcc atccgtgtcg ttgttgggtg
     5821 taccatattt gccggattca aatgttcctc catagatatt gattttccca ttctctcttg
     5881 cataaatcag gtctatctgg gtgttcagtt tctgggtgtt atagtaagaa ccgccatgaa
     5941 tatttactgt cccgtgtcct cgggcttcaa ttaccatgcg ataaccatcg tctttcgctg
     6001 tagcagatgc atcgcacttc acattgccgt tgcctgaaat gtttagtgtt ccgttctgta
     6061 cagtaaagat ttgtgtgaaa ggagtggcat cagctgtttc tgaggaattg atgatgtcgt
     6121 ggccattcag gtttaagttt gccgttgcgt ttgcagcatt caatatgtag cctgtggcaa
     6181 gctccgtctt ggcgatgttg atatttgaga gaagttttat atccacagtt gcgttggttg
     6241 ccatgtactt cagtacgctt gggtcggaga atgtacctcc ggaaacagag atgatacttt
     6301 tggcattttc ggttcccacg gatgcatcta cctttaagtc accgttgaaa gtaccgcctg
     6361 tgatattcag cttcataggt tcggtatttc ctgcactctt ggaaatttcc acttttccat
     6421 tgatgacgct cgtaccgctt accgtaaccg tgactccagc agtgtacttt gcatagccgc
     6481 atacgtcgaa tgcaaattga ttcgcattgc ttcctgcgtt gatagtggta ttgttgatgc
     6541 ttatattgcc acaattgttg cttactacgt attgggcatt tgtgtcttct actgtcatat
     6601 tatctaatgt caggttgcag tagttctgaa tcatgatttt gttgttgtca ctcttcagcg
     6661 ttccgttctt gaaagtaacg tttgaacctt cgagtaattg acagctgttc gtttcggtgc
     6721 cggtggaacc tacggtcggg tcagcaagtg taaggatctt gccgcctaag tccatcgtca
     6781 aggtttgtcc gcttgtggtc ttgaatcccg ggcaggtctt gtcggcggtc aactttatgt
     6841 tcacatttgc atttgtcttc atgtacttca gcgcgcttgg gtcggagaat gtaccgccgg
     6901 taacgttgat gaccggtgta taagtggtgc cttctgtgat gagtgacttt gcttcggcaa
     6961 tcagtgtacc gcctttgatg tttactgtgg caatgccata tgctccactt acgttgatgg
     7021 cggcgcagtc cagtcctccg gtaccgtcgc cccagttgcc ggtgctgcct gtgcctttac
     7081 tggtaatcaa ggctgtgcct tccacgttca gagtgcctcg ttggatgcat acacctcctg
     7141 cggcaccata aaccttgccg ccactgatgg tcgttgtgcc ggattggggc agatagactg
     7201 catagtcagc agtagaaatg agttctccgt ctgtgatgtt gatgatggag ttctgcgtct
     7261 tgtaattgcc gttgcctgcc actgcaaacc atccggcttc tatcttgccg cctgtcatgg
     7321 tgaagtctcc accgtccgtc actccgacgc catattggcc gttactgttc ggagtctttc
     7381 tgactgcact gatgttgccg ctttccatgg tcatggaggc atcttcaccg gctatttcaa
     7441 tcagactgcc attataagaa gccgctgtat aatcctggct ggcaactatc ttgcctttct
     7501 tctcggtaga gctgtccttc agtgtcatct tgcccaagac gatgattttg cctgttgcgc
     7561 tgttgtcggc agtcagtgta tatccgttca agtcaagaac cacggacttt ccggcgggta
     7621 cactgacgct ttgccctgtg atgtcggcat cggcggacaa tttaaaatct tcgccgttgg
     7681 cgaaagcggt ctttaggact gccacgtcgg attgaactac aaatttgctg tcgattgttg
     7741 ccggaagtga tgcttcagtt ccttttatta tatagattgt ggtattgccg gcatcgtgta
     7801 ccaattgttc tacctttcca tatatcttca agttaccgcc ttttacggtc agcttcttta
     7861 cggtgacgcc tgcattgata atcaatgtct gctgggcggt agtggcagtc acttcattgt
     7921 aagtggcttt attgcctact gctgccaatg taacggtggt gcttggcatg gtgatggcta
     7981 cagaaggagc ttcttgctct gctgtggttt ccggcacagc caaggataca ctgttggtgg
     8041 cagtggcggc gggagtactt acgctggtat tggtcttgtc ggtcagcttt aacggggcag
     8101 aagtgctggt tgtcggggct gtattgaacg ccaggttgat gtccgagttc tgtaaaaccg
     8161 ggatggcgat gccgtcgttg ctgccagaag tggtattgaa gctgccgctg actgcaatgt
     8221 cggttacggt tgctgctgtc ggtgcttctt gtgggagatt ttttgaatca gctaaagctg
     8281 tactaagcgc actgggggtt gtagcctcta ccacaacgca atccaaagga ggtactacca
     8341 atatgtctct tctgcctagg attttgtcat taagcgtctt ggtaaaatat accttgtcgc
     8401 ttccattcgt cagttgggca gtgatggaac tataagtacc tgtgggcaaa ggaatgtaga
     8461 agttgcgaga ctttatatca gctgaggctg tgaaggaggc ggtgatttcc ttgctttcat
     8521 cgctcgttac tgccagtatc gggtctgctg cggttaagtc taccgtacaa gtacctgcaa
     8581 tgttattgga ggcaataatc ttgaaagtag tggcctctgc cggaatcttg ttgacggtca
     8641 gttttatcat ggctgccatg tgcttgaagg acagagcgct cagattgtcg ggatttgtca
     8701 ccttggcata catcgggcca ttgctgctgc cgttataatt tgtaagcgtg gcaggtagag
     8761 tcatggtcaa tgtattgccg cttacgctca tgttttgttg gtaaggatag atggagaata
     8821 cagccgtttc tccgcttggc ttgctgccgt tgaaagtggc ggaagtttga ccagcaccgc
     8881 ttgcatattc taattttgta ttgctataat tactttctgc attactacag aacaacccta
     8941 gggcatcggt atcttgccat agaatcttgt attcatcgtt tacggtagta cgggtgtcgg
     9001 tacctgcgcc ttcaaacgtt gcgttaacgg tgatgtttcc tttccacccg ctgttttcaa
     9061 attcctcttg gctgcaactg aatgcggtca aggcagcagt tgccatgcag gcaacttgca
     9121 taaggtttct taatttcatc ataatgaagt cccccttagt tttctacggt taagatgtca
     9181 ttgattaggt cttccaagtc gctgctggat gccgaattgt agctatgggt agaggtgctg
     9241 cccgaatagg agcgcgtaat gggatggtaa ggttcgccgc ttgttgcaat gactccttca
     9301 ttctccattt tgataacttc gatagacgga gtgatgtatg cttctctacc gtctggtgtg
     9361 ttctgtttca tatacacaaa ttatttaaag gttaaacaat aaaaaaaacg tgagtaacta
     9421 tgtttgtata tcctttattc aggccttcgc attgcccttt ccctggatat acaacagtca
     9481 ctcacgtcgt ttgtgtatat actatccccc ctgatgggag aaaaccatat aaacatagac
     9541 gtgagcatcc ttgttgttat cttcagggaa attttcaaag ttgcgaagtt tgaataaaga
     9601 agataatttc aataatgctc ttactaatat gtaaataaac ccactacgct atagcggatt
     9661 tgtgacaaag ataattgttt tttgtttaag tgtatctatg tttctctatt ttttttggga
     9721 aaggctcacg tctctttcat ttataggagt taggagagtt atcacttcta actcccgata
     9781 actccttcaa atatttagta actgtctgca ttgtctttga ggatgttttt ctgaggagca
     9841 tagcggctat gtggcgaata aagaggggaa gacagaccga aaagaagctg aataaaatct
     9901 ttttaagcaa aattaaaaca gagatttgat atactttaaa cagaacaccc tgcaaactcc
     9961 ggcttgctct gtccggcagt ttgcagggtg gctgcttggt tttctcgcgt gtacgtagct
    10021 ccttatgcca cgaacggaag tcgatgccat agcaattttt cataataaga ctttccatat
    10081 ttttgcaaat gtccgtactg cctttggctg aaacaattta tataagtaat tgaagtttcg
    10141 taagtgagta tgcctgctga taaatgggaa tttatcgcac agagcgcgaa gcctgctctc
    10201 ataacctatg gagagcacga gtgaaagctt gtggattttt atctaaaaca taggtattcc
    10261 tttactcttc tccctttgtt tgtctgctgt ggcataggga atttatgacg cctaacggcc
    10321 atgaacaacc ctgctttcga ccataaagca atcgtttgac gaccgtaagc agagttgttc
    10381 atggccgtta ggcgtcacta actccagagc tattacagat gaagtacgta gcccgaacct
    10441 attgcgcaca aggcgcaaac gtattataca acggtgtaaa agacattaga gtgcattatt
    10501 catagtcggc ctttgattcc cgataactcc tactatgctc ctacagtcca actccatatc
    10561 cgttgacttc acagtaagga caagcccgaa aatgcaggaa aaccgaacct gccgattcat
    10621 gtaatctgca tgcagtatta tgctagggga tagcagctta ctgcaaaact caggcgtttc
    10681 aggcaggtgg aagcaaattt tgcttccacc ttttcaggtt gcttccatcg cagggcaaat
    10741 gccgatggac agggggatgc aggaggtggg tggaagtgtg gaagcaaagt gatggaaaat
    10801 taatttggca ttcacacaat aataaccgta tatttgtagc atggctgtct gcctcctctt
    10861 aaattcagat aaagaggagg tagacaaatg cttgctatga gaaacacata aatggttata
    10921 accaagtgat gaaacaatta attgcatgtt gcggactgga ttgcgaaaat tgcgccgccc
    10981 gtatagccac tgtcaataat gacgatgagc tgagagagaa aaccgccaaa gagtggagtg
    11041 tgctgaacaa tacgccggaa attacggcgg aaaccatcca ttgtatgggg tgccgtgcag
    11101 acggggtgaa gtttacctat tgcagcgatt attgtgctat ccgcaaatgt gtgtacgaaa
    11161 aaggtttcaa tacttgtggc gactgtaagg aactggatac ttgccaggtg gtaggtgcgg
    11221 ttcttcagca tgcgcccggt gcaagggaaa atctttatta accgtaaaat ctttgattaa
    11281 ataaaatatt gcttatcttt gcagtatgac aaagacattt aaatcggatt tggttttgta
    11341 aacaatctgt gttccatgca cagattgtcc cctttcgttt actttcggat aacttctttc
    11401 gagagtgttt ttctattgtt ataattcaag tttaatccgc atattatgct gaaggtgttg
    11461 tgatactttc cgtatatgca aaatatagta agaaaatgag taacgaaaat aaaactatcc
    11521 acgatttcga atttaattta atctgtgact ttttctccaa tatggaacgg caaggccctg
    11581 gcagtcctga agtgacgttg aaggcattga gctttgtaga cggtcttacc gatgaatccc
    11641 ttattgccga tatcggttgt ggaacgggtg gtcagacaat ggtattggct ggccatgttc
    11701 cgggacagat taccggaatt gaccttttcc ccggctttat tgacatcttc aaccgtaatg
    11761 caaggcagtt gggcttgcag gacagagtaa aaggaattgt cggttcaatg gatgccctcc
    11821 ctttcggtga ggaggagctg gatatgattt ggtgtgaagg tgctatctat aacatcggct
    11881 ttgaacgtgg cttgaaggag tggcgtaaat atctgaaacc gggagggtat attgccgtat
    11941 ccgagagttc atggtttacg gacgaacgtc ctgcggaaat caatgacttc tggatggacg
    12001 cctattctga aatggataca cttcccaatc aggtgaccaa gttgtacaag gcaggttatc
    12061 ttcccgttgc tacattcatt ttgccggaga attgctggac agagcattac tttgcttcaa
    12121 aggttgcggc tcaggagatt ttccgtaaga aatatgccgg taataaaatt gccgaagagt
    12181 tcagcttact ccaaatgatt gaggatgaac tgtacggcaa gtataaggaa ttttacggtt
    12241 atgtgttctt tattgccaag aaggtaggct gatgacggac ttctcttatt gaggaatgcg
    12301 ggtattctca ggacagaata tccgcatttt gggttttgag tagattttat tgttttgagg
    12361 atgtacggaa cttctgagga ggtattcccg tatgacgttt aaagaatttg ttgaagaagg
    12421 ccgcattatt aaaacctaga ctcacggcta tatcctttat cggagtgttg gcggtacaaa
    12481 gttgtgcttt ggcatccatg atgatagtat tgttgatgat ttccatggct gtatatcctg
    12541 attccttttt gacaaggcgg caaagagctg ccggtctcat attcattttc aatgcataat
    12601 aggacacttg atgctcccgg acatagtctg tgtgtaccaa tcggataaaa atgcggtatt
    12661 ggttgaaatg cctgctgccc ggagtctctt ttattctagg gcgttccgga cagagttcgg
    12721 atataccttg taacagatag gtcagtagag tttgcaatga aactagactt gaggggcttt
    12781 ctgttctttg gtagaggtgt gacaaatagg tcatgaactc ggcataaagc tggaagtccg
    12841 ttctcgatag aggaaaaata tagtgtttgc ctataatgtg aaacttatcc atcatgacct
    12901 tgccggcccc tgaactctgg ataagttgtt gggaaaatat gacgacatat atttcagcat
    12961 cgtctgacgt gtgtagcaat tgtacgaagg tctcgggagg aataactagg agggcgttag
    13021 cttcaaccct gaattgagta tggtttatga tagttttcag aactcctttg gtgcatagag
    13081 cgaagatact ggccttggtg tggtatggct tttccactag cggattcagt tcattggttg
    13141 tgatatgatt gcaggcaatg aactcgtcat ttatattgaa ttcggatata ttcatgttgg
    13201 agattttaag acgcaaaaat gggggataat aatgtataaa tgacagaggt aacagttaaa
    13261 atcaatatta cgctcaactt atctctgtta aataaggtaa agttgtgaat aatagaatat
    13321 aagtaactaa tcaaaattaa gcagcataat ggctaaagtt aatattcagt cg
//
