LOCUS       c00051_gnlPro..        14266 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BHFHGDGE_51.
ACCESSION   c00051_gnlPro..
VERSION     c00051_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 16:29:35
            Original ID  :: gnl|Prokka|BHFHGDGE_51
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14266
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14266
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1077:5935]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1078..5935
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /neighbourhood="10000"
                     /product="TPP_fatty_acids"
                     /protocluster_number="1"
     cand_cluster    1..14266
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /kind="single"
                     /product="TPP_fatty_acids"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14266
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_fatty_acids"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and (minimum(2, [ACD1_car,
                     ACP_syn_III_C, AcetylCoA_hyd_C, AcetylCoA_hydro,
                     Acyl-CoA_dh_1, Acyl-CoA_dh_2, Butyrate_kinase,
                     CT_Propionyl_CoA1, CT_Propionyl_CoA2, CT_Propionyl_CoA3,
                     Carboxyl_trans, CoA_trans, CoA_trans_230_acto,
                     CoA_trans_2_CAF, CoA_trans_6_Glutaconate, E1_dh, ECH_1,
                     ECH_2, HBT, HBT_2, HCDH, HpaB, Ketoacyl-synt_C, Thiolase_C,
                     Thiolase_N, adh_short, adh_short_C2]) or FA_synthesis) and
                     not (PFL-like or PFL_6_pcresol or PFL_9_tma or Gly_radical
                     or Gly_430_pcre or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and not
                     (POR or POR_N))"
                     /tool="gutsmash"
     CDS             2..817
                     /locus_tag="ctg51_1"
                     /transl_table=11
                     /translation="NKSMNYKLLVLDLDGTLTNSKKEITPFTRETLLQAQEKGLHLVLA
                     SGRPTYGIVPLAEELNIKQYGGFILSFNGGKVIDLMTDKVLFEQALPPDIVPVLYNRSK
                     EAGLAILSYNGKYILSEHPENKYVQYESFLTKMKIKATDDFLRDLHQPADKCLVVGEPE
                     MLVPLEEKLRQELGKRINVYRSEAFYLELVPKGIDKAASLSRLLERTRIKQEEVIAIGD
                     GFNDVSMIRFAGLGVAMANAQPPVKANADRITQYTNDEDGVARFIQELL"
     CDS             1078..2310
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: HBT"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_2"
                     /sec_met_domain="HBT (E-value: 1.4e-17, bitscore: 53.4,
                     seeds: 132, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYKLLVLDVDGTLLNDKKEITPRTHAALLKAQQMGVHVVLASGR
                     PTNGVQPLAEALELNHYGGFILSYNGGQIINAQTGELMFEKRIDPAMIPYLNRKAKENG
                     FAIFTYHKDYILTDSPENKHVQEEAELNKMRIIGVENFPEAVDFAPCKCILTSDDENNL
                     VGLENHWKKRLDGVLEAFRSEDYFLEVAPHFINKGNTLAVLMEMLNITTEEVVAIGDGV
                     ADVSMLQLAGTGVAMGNARDSVKACADFTTLPNNMEGVAVAIEKAILATIKPTEVPLDQ
                     LNARAKHALMGNLGIQYTYASEDRVEATMPVDERTRQPFGILHGGATLALAETVAGLGS
                     MILAKPDEMVVGMQVSGSHMSSAHEGDTVRAVGTIIHKGRSSHVWNVDIFTSTDKLVSS
                     VRVINSILKKK"
     CDS             2307..3404
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Chorismate_bind"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg51_3"
                     /sec_met_domain="Chorismate_bind (E-value: 1.2e-54,
                     bitscore: 174.9, seeds: 119, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIPRDSYEIIDTLIKQGRSFAIWRIPGEDRLHFRMQSAGSPCLLY
                     DIKDLNERSGFVIAPFQVTAERPIVLIQPDCFEIPSESDWDFSREKNEFPSNEIEIPSE
                     SEEKERYAYHFSLFTNPLLKGSQDKLVLSRSKTIWKDPSFSPGKAFFAAEERYIRSYVY
                     LCHTPETGTWMGGTPEILLSGEKGDWQTVALAGTQSLRDGKLPKSWDHKNWREQQLVAS
                     YIRRQLSTLGITPEEKGPYSARAGEVSHLKSDFFFSLPNPEKLGDVLQLLHPTPAVCGL
                     PKEEAYHFIIENEGYDRSYYSGFIGWLDPKGKTDLYVNLRCMNILPQTFTLYAGGGLLA
                     ASQLEDEWQETEDKLDTMRRIVGNL"
     CDS             3419..5107
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 7.2e-08, bitscore:
                     21.8, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDKKNILQLVALLIEHGVSNIVLCPGSRNSPIVHTLANHSFFN
                     CHSVTDERSAGFFAVGLALHGGKPAAVCCTSGTALLNIHPAVAEAFYQKVPLVVISADR
                     PAAWIGQMDGQTLPQPGVFGSLVKKSVQLPEIHTDQDEWYCNRLINEALLELNHHGKGP
                     VHINVPISEPLFQFTTPELPKVRVITRYQGLNVYDRKYDDLIERLNKYSKRMMIAGQMS
                     LIYLFEKKICKLLYKHFTWLSEHIGNRIVPGLPIKNFDAILYATPEEEKEKLVPELVIT
                     YGGHIVSKRLKEFLRKHPPKEHWHVSLDGEVADLFGSLTTVIEMDPFEFLEKIAYMLEN
                     RQIEYPKAWEYKSRNLPEPEFAYSEMAAIGGLIRSLPAESALHLGNSSTVRYAQLYTVP
                     ETVEVCCNRGTSGIEGSLSTAIGYASASQKLNFIVIGDLSFFYDMNALWNGNLHNNLRI
                     LLLNNGGGEIFQALPGFKMNERTHRYVTASHQTSAEGWATERGFSYSAVHNAEELAAAM
                     SAFTQTEQPSEHPLFMEVFTDKAEDVRLLKEYYHQLKNSSQAQNI"
     CDS             5111..5935
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_fatty_acids: ECH_1"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg51_5"
                     /sec_met_domain="ECH_1 (E-value: 2.6e-82, bitscore: 265.2,
                     seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="METKREWTTIKEYEEILFDFYNGIARITINRERYRNAFTPTTTTE
                     MSDAFYICRERPDINVVVLTGAGDTAFCAGGDMNVKGRGGYVGKDGVPRLNVLDVQKQI
                     RSLPKPVIAAVNGFAIGGGHVLHVVCDLTIASENAIFGQTGPRVGSFDAGFGSSYLARV
                     VGQKKAREIWFLCRKYNAQEALDMGLVNKVVPLDKLEDEYVQWAEEMMLLSPLALRMIK
                     AGLNAELDGQAGIQELAGDATMLYYMTDEAQEGGKAFLEKRRPRFEDYPKFP"
     CDS             5972..7030
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MR_MLE_C"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg51_6"
                     /sec_met_domain="MR_MLE_C (E-value: 1.5e-29, bitscore:
                     92.5, seeds: 401, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKERLYRIEVVPRCLTFKRPAGTSRGVYTTRKLWEVRIRKEDEP
                     SVIGIGECAPLPDLSCDYGVDYEITLSKACLDLEQKGHVDTESLRHYPSILFGLEMAMR
                     HYEQGSWRHYDTPFSRGQVGIPINGLIWMGDYKYMLEQVEEKMKEGFRCVKLKIGAIDF
                     DRELSLLKHIRAHFSAKEIELRVDANGAFLPSEAMDKLKRLAEMDLHSIEQPIRAGQLE
                     EMARLAAESPLPVALDEELISCNAPDEKQRLLETIHPQYIILKPSLHGGISGCTEWIHL
                     AETILGSTPEQPKWWVTSALESQIGLNAIAQWCATLGNPLPQGLGTGEIFKDDKHTLIQ
                     RKGDTIWFTNDL"
     CDS             7034..8032
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1025:AMP-binding enzyme (Score: 53.3; E-value:
                     5.7e-17)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg51_7"
                     /sec_met_domain="AMP-binding (E-value: 9.2e-18, bitscore:
                     53.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPIQEDLQAFLAEWHDPSPFLEVQTSGSTGTPKRMRVRKDRMLNS
                     ARLTCDYLGLKKGDKALLCMPLRYIAGKMMVVRSLYAGLDLEVCEPSGHPLADWGDTPL
                     RFAAMIPLQVYNTLRVPEERKRLEQTDILIIGGGAIDAALEQEIRQMPNTVYSTYGMTE
                     TLSHVALRRLNGPEASPYYHPFPSVTLSLSPDNTLVIDAPLVCDERLVTNDVARLLPDG
                     SFAIIGRKDNIINSGGIKIQIEEVEERLRPYLDRPYAITAAPDPRLGEAVVLLLASNLR
                     GEMLTEVLASLPKYLRPRHIIKVSEIPQTGSGKIDRAACRELARNIITKTL"
     CDS             8035..9996
                     /locus_tag="ctg51_8"
                     /transl_table=11
                     /translation="MKRILTITAVSLLALSPMYGQDSCRYPQDPTLEKSQAYAGYDCVT
                     LLDSTAVTVQPTGSGAFAVCKAFKVQTSKGAVANRIIKYDYDPLTAHAEFRYATIYRAN
                     GDVINLDVTQACDYAAPARAIYWGARQIMLEVGRLQPGDIVEYEIAKKGFTYALLTAGD
                     DDERFIPPMRGQFYDIVPFWATEPTVRKVYRVSMPMEKELQFQFYQGECTSSMRYEDRR
                     KVYTFASDDILPFAKEPNMVDLFDAAPKLMMSSTPRWEDKSLWFNKVNEDYGSFTAIPE
                     AQKKVDELIKGKKTEMEKIAVLTHWVADNIRYSGISMGKGEGFTLHNLKMNYTDRCGVC
                     KDIAGTLIAFLRMAGFEAYPAMTMAGSRVESIPADHFNHCVAVVKLASGTYMPLDPTWV
                     PFCRELWSSAEQQQNYLPGVPEGSDLRLTPVSAPENHYVRIHADNRLDEKGTLRGQFTI
                     TAEGQSDSNIRRIFTTGWQSDWQNTMEKQLLAVSPNAKLLRVDYGKDPKNYQAAPIKIT
                     FSYEIPDYAIIAGDQMLIKPLVMNNLYNQVKSFLRIDTKPENRAYGFKDACSRLVEQDE
                     TIRLPKGYTLLNAPKNDVLQSNAADFEGSLSQEGNQNIVLRQKLALKKRVYDAADWKGF
                     RSAVNAYKSYGDYLIIKK"
     CDS             10010..11608
                     /locus_tag="ctg51_9"
                     /transl_table=11
                     /translation="MIKITYKLILLLGLLAMTVTSFAASEAEYGKVSKAWTLHADGSQE
                     YRSSMELTLFTHTAMNSTYGESFIVYNPDFQTLKIHSSYTRQKDGTIVKTPDNAFVEVL
                     PRFAADAPAYNQLKEMVVVHTGLELGATIYLDYSIITKPGYYPAMDINERLQETSPVKE
                     CKVSISVPENSPLAWQLLGSDAKASQATRNGAKEVSWTLRNLPASSREAFLPQNQDGIP
                     RLIASSYSSNKEALSTLNKRFNTSGNYESKTFGSYITEKATSDEEKVNAIRNHVVNNMG
                     YCAIPLACTGYSIRDVDTALRSAYGTLAEKTQLLNVLLNAAGIQSEVVAVYPGNLDIDA
                     CGLSTIKNLAVKATVAGKDKYLSAVSLAPSALTARGELDQVLTLNGTSIALQAEPTIIK
                     ENKAVSVSKNEAQNGFAICTLPAITGGIDSWGMSALNSKRSNLFELPSLIKEEVTYTVT
                     PAEGMKLQTSTKEQVISKPFGKVTRTITPRGNTIEVVRTIELDKQQFTPAEYSDVRSLI
                     HEWTNPDNRVLLFSL"
     CDS             11755..14265
                     /locus_tag="ctg51_10"
                     /transl_table=11
                     /translation="MKTLKYLLATMLLLGVCNLTHSQKLSLGIFPEPQEVTISSQTYTP
                     PHGYTLRGINNPDADAVKLLKEALPFAKSGKSLPLEIKKLKDKTPEMQRSGAYTLAITK
                     KGITIGIVDDNSLFYAAQTLKQLAKYDEGKKILPLCSIKDYPDVLFRGTVEGFYGQPWS
                     HADRIEQIRFYGRIKLNTYLYGPKDDPYHSSPNWRKPYPAEEAEHIKELAKEAAHNKVN
                     FVWAIHPGQDIQWDQADSMNILSKFEKMYDLGVRSFAVFFDDISGEGARPEKQAGLLNY
                     IHKEFISKKNDVQPLIMCPTEYNRSWAKTDYLDILGTQLDPAIQIMWTGDRVVADITKE
                     GVEWVNNRIRRPAYIWWNFPVSDYCQDHLLMGAAYGLDTQAAGTMTGFVSNPMEYAEAS
                     KVAIFGVGMYTWNIKNYDPTQAWKDACDFIMPEASMAFRIFCEHNCDPGPNGHQYRREE
                     SANYVAPIQTFLTGYKKNTFPEQSANLLGTLFAQITASPSMIYSQSPNKRLIEQINPWL
                     IQFEFLGKAGTSALHMAHAWYEKDRSYTWQRYLETSALLDSMKLINRTLNQKAQPKGVK
                     VGSKVLHPFIVDLYRQTGRNLLSTDGIAPDEVKVSIPSIFTNIDQLKSQPCAEGDNTVG
                     YVPLFEVVKVQPNQYLGIGWEIQKEAESFCFNLPKSNQPGRVFEWSADGKSWSLIPHVS
                     TENAKDTICAIDPKARYIRMRNNSDQQMELYVLGFTATTKQDPQINEALMMYDMNLDTY
                     KNLNPGEIIHIKCDDINAVSFFLSGSNENLVSITGLSQDGEKNIVYQGNVGYIKLNKTM
                     FEDFSSLEITTIGKEPIHIHQIVRE"
ORIGIN
        1 aaacaagagc atgaactata aattattggt actggattta gacggtacac tgacaaacag
       61 taaaaaagag atcaccccgt ttacgaggga aacccttctg caagcgcagg aaaaaggatt
      121 gcatctggtc ttagcctccg gccggcccac ctacggtatc gtgcctttag ccgaggaact
      181 gaacataaag caatatggtg gttttatcct ttccttcaac ggcggtaagg tgatcgactt
      241 gatgacagac aaagtacttt tcgaacaggc tttgccaccc gatatcgtac ctgttttata
      301 caaccgctcc aaagaagcgg gactggctat cctttcctac aacggtaaat atatcttaag
      361 cgagcatccg gaaaataaat acgtacaata cgaatctttc ttaaccaaaa tgaagatcaa
      421 ggctaccgac gattttctgc gggatttgca tcagccagcc gataaatgct tggtggtagg
      481 cgaaccggag atgttggtac cgttggaaga gaagctccgc caagaattag ggaaacgtat
      541 caacgtatat cgttccgagg cattctatct ggagcttgtc cccaaaggca tcgacaaagc
      601 cgcctcatta tcccgcttac tagagcgaac ccggataaaa caggaggaag tgatcgctat
      661 cggcgatggt ttcaacgatg tatccatgat ccgtttcgcc ggattgggag tcgctatggc
      721 caacgcccag ccccctgtca aggccaatgc cgaccgcatc acccaataca cgaacgatga
      781 ggatggagtg gctcgtttca tccaagaatt gctttgaaaa aaaacacgta cgtattttcc
      841 gaaaaacatg tacatgtttt cgcgagaaca cgtacgtgtt ttttcagaga catttacacc
      901 agtatcgaca caggccaatg cctataccgg catacgccta taccagtagt gccgtagggc
      961 tacgccagta tagtcgtgag cttgcgccga tatacgtaaa ttcctttcat ggaaatgtct
     1021 tctaactatc aactatttta tgtatatttg tattctaaac cataaaaata agacgccatg
     1081 aagtacaaat tattagtctt agacgtagat gggacgttgc ttaacgacaa gaaagagata
     1141 actccccgga cccatgccgc cttgttaaag gctcagcaga tgggagttca tgttgtattg
     1201 gcatccggcc gacccaccaa cggggttcaa cccttggcgg aggcccttga attgaatcat
     1261 tacggtggtt tcatattatc ttataacgga ggtcagatca tcaatgccca gaccggagaa
     1321 ttgatgttcg agaaacgaat cgatccggcc atgattcctt atttaaaccg gaaggcgaag
     1381 gaaaacggtt ttgctatctt cacgtatcac aaggactata tcctgaccga tagcccggaa
     1441 aacaagcatg tccaagagga ggccgaactc aataagatgc gcatcatcgg tgtggagaat
     1501 ttcccggaag cggtggattt cgcaccctgt aagtgtattc ttaccagcga tgacgagaac
     1561 aatctagtgg gtctcgaaaa tcattggaag aaacgtctgg acggggtatt ggaagctttc
     1621 cgctccgagg actatttctt ggaggtagct cctcatttca tcaataaggg aaatacgttg
     1681 gcggtattga tggagatgct gaatatcacg accgaagagg ttgtcgctat tggtgatggc
     1741 gtggccgacg tatccatgct tcaattagcc ggtaccggcg tggcgatggg taacgcacgc
     1801 gattccgtaa aggcttgtgc cgatttcacg accttaccca ataatatgga aggtgtggcg
     1861 gtagcgatcg agaaagcgat ccttgccacg atcaaaccca cagaggttcc gttagatcaa
     1921 ctaaacgcac gggccaaaca tgctttaatg ggtaatctag gcattcaata tacctatgcg
     1981 tcagaggatc gtgtggaagc gaccatgcct gtagacgaac ggacccgcca gcctttcggt
     2041 atcttgcacg gaggcgctac actggctctg gcagagaccg tggccggact aggttccatg
     2101 attctggcga aaccggacga gatggtagtc ggcatgcaag ttagcggcag ccatatgtcg
     2161 tccgcccacg agggagacac ggtacgtgcc gtcgggacga ttatccacaa aggccgttca
     2221 tcccatgtat ggaacgtaga catattcacc tctaccgaca aactggtttc ctctgtacgg
     2281 gtaatcaata gtatactaaa gaagaaatga ttccaagaga ttcttacgaa ataatagaca
     2341 cgttgatcaa gcaaggccgg agtttcgcta tttggcgtat tcccggtgag gataggctcc
     2401 atttcaggat gcaaagtgct ggctctcctt gcctattata cgacataaaa gacttaaatg
     2461 aacggagcgg ttttgtaatc gctccgtttc aggtgacagc ggaacgacct atcgttttaa
     2521 tccaaccgga ttgctttgaa atcccctccg aatccgattg ggatttctct cgagagaaaa
     2581 acgaattccc ttcgaatgaa atcgaaatcc cgtccgaatc cgaggagaag gaacgatacg
     2641 cttaccattt ctccctgttt accaaccctt tgctaaaagg aagccaagat aaactagtcc
     2701 tatcccgtag caaaacgatc tggaaagatc cctctttctc acccggcaag gcattcttcg
     2761 ccgcggaaga acgatatatc cgctcctatg tctacctttg ccataccccg gaaaccggaa
     2821 cttggatggg tgggacaccg gaaatcttgt tatccggcga gaaaggtgac tggcaaacgg
     2881 tagctttggc cggaacccaa tccttacgag acgggaaatt accgaaaagc tgggaccata
     2941 agaattggag agaacagcaa ttagtcgcct cctatatacg ccgccagctg tccaccttgg
     3001 gtattactcc cgaggagaag gggccttatt cagcccgggc cggagaggtt tctcatttga
     3061 aaagtgattt cttcttctcc ttgccgaatc ccgagaagct gggtgatgtc cttcaactat
     3121 tacaccctac tccagcagtt tgcggtcttc ccaaggagga ggcttatcat ttcatcatcg
     3181 agaatgaggg gtacgatcgt agctattact ccggtttcat cggttggctg gatcccaaag
     3241 gcaaaacaga tctgtacgta aacctccgtt gcatgaatat cctcccccaa acctttacgc
     3301 tgtatgccgg aggcggtctg ttggcggcct cgcagctaga agatgagtgg caggagacag
     3361 aggataaatt agatacgatg cggagaatag tgggtaattt ataattttat atcatataat
     3421 gtatagcgat aaaaagaaca tccttcaatt ggtagccttg ctgatagagc acggcgtaag
     3481 taatatcgtg ctatgtccgg gaagccggaa ctctccgatt gtgcacacat tggcaaacca
     3541 ttcgttcttc aattgccatt ccgtgacgga tgaacgaagc gcgggattct ttgccgtagg
     3601 gctagcgttg cacggaggta agccggcggc tgtttgctgt acctcgggca cggccttgct
     3661 gaatatacat ccggcggtag cggaggcttt ctatcagaaa gttccgcttg tcgtgatatc
     3721 cgccgaccgc cccgccgcat ggatcgggca aatggacgga cagactttgc cgcaacccgg
     3781 ggtgttcggc tcgctggtaa agaagtcggt gcagctaccg gaaatacata cggatcaaga
     3841 tgaatggtat tgtaatcgat tgatcaacga agcgttgttg gaactgaacc accacggcaa
     3901 aggaccggtg catatcaacg ttccgatctc cgagccttta tttcagttca cgacacccga
     3961 attgccgaag gtacgggtaa tcacccgtta tcaaggcttg aacgtgtacg accggaaata
     4021 tgatgacctg atcgagcgct tgaacaaata tagcaagcgg atgatgatag cgggacaaat
     4081 gagcttgatc tatctcttcg agaagaaaat atgtaagtta ctatacaaac atttcacttg
     4141 gctctccgag cacatcggca accgtatcgt accgggatta ccgatcaaga atttcgacgc
     4201 tatcctgtat gctaccccgg aggaggaaaa agagaagcta gttcccgagc tcgtaatcac
     4261 ctacggcggc catattgtct ccaagcggct gaaagagttt ttgcggaaac acccgcctaa
     4321 ggagcattgg catgtctcat tggatggaga ggtagcggat ttattcggta gcctgaccac
     4381 ggtgatcgag atggaccctt tcgagtttct ggagaaaatc gcttatatgc tggagaatag
     4441 gcagattgaa tatccgaagg cttgggaata caaatcccgg aacctgccgg agccggagtt
     4501 cgcttactcc gaaatggcgg cgatcggtgg tttgatacgc tcgcttccgg ctgaatcggc
     4561 cttgcatctg gggaatagct ccaccgtacg ttacgcgcaa ttgtacaccg tacccgagac
     4621 ggttgaggtt tgttgtaacc gaggtacgag cgggatcgaa ggctccttgt ctacggccat
     4681 cggatacgcc tcggcctcgc aaaaactaaa ctttatcgtt ataggcgatc ttagtttctt
     4741 ctatgatatg aatgcgttgt ggaacggtaa cttgcacaat aaccttcgca tcctgctctt
     4801 gaacaacgga ggtggcgaga tcttccaagc cttgccggga ttcaagatga acgagcgtac
     4861 gcaccgttac gtcaccgcct cccaccagac ctcagcggag ggatgggcca cggaaagggg
     4921 attctcctac tccgctgtcc ataatgccga ggagttggca gcggcgatga gcgcctttac
     4981 ccaaacggag caaccgagcg aacatcccct attcatggag gttttcacgg acaaagcgga
     5041 agacgtacga ttgctcaagg aatattatca tcaactaaaa aattcatccc aagcacaaaa
     5101 catataatat atggaaacaa aaagagaatg gacaaccatc aaggaatatg aggagatctt
     5161 atttgatttc tacaacggca tcgcccgcat tacgatcaac cgggaacggt atcgcaacgc
     5221 ttttaccccg actacgacca cggagatgag cgacgccttt tacatctgcc gggaacgccc
     5281 ggacattaac gtagtcgttc tgacaggagc cggagatacg gccttttgcg cgggaggcga
     5341 tatgaacgtg aaaggacgtg gcggctacgt gggtaaagac ggcgtacctc gcttgaacgt
     5401 attggacgta caaaagcaga tccgctctct cccgaaaccc gtcatcgcgg ccgtgaatgg
     5461 tttcgctatc ggcggcggac acgtattgca cgtggtttgc gaccttacga tcgcttccga
     5521 gaacgctatc ttcggacaga ctggtcctcg tgtgggtagc ttcgacgccg ggttcggctc
     5581 ttcttacctc gcccgtgtgg tcggacagaa aaaggcccgt gagatctggt tcctatgccg
     5641 caagtacaat gcgcaggagg ctttggatat gggtctggta aataaggtag tccccttgga
     5701 taaattagag gacgagtacg ttcaatgggc cgaggagatg atgttgctta gcccgttggc
     5761 tttgcgcatg atcaaggcgg gcttaaacgc cgagttggac ggacaggccg gtatacagga
     5821 gttggccgga gacgctacca tgctttacta tatgacggac gaggcgcagg aaggcggtaa
     5881 ggcattcttg gagaaacgcc gtccccgctt cgaggattac ccgaaattcc cgtaggggga
     5941 ttgagaatga ataatgaata attaagaatg aatggtaaag gagaggttat ataggattga
     6001 ggtggttccc cggtgcttga ctttcaagcg accggcagga acctcacggg gtgtttacac
     6061 gacccggaaa ttgtgggagg tccgaatccg taaggaagac gaaccctcgg ttattggtat
     6121 cggagaatgt gcccccctgc cggatctcag ttgcgattat ggagtggatt acgagatcac
     6181 gctatccaag gcttgcctcg atctggaaca gaaggggcat gttgacaccg aatctttgcg
     6241 ccattaccca tccatccttt tcggattgga aatggccatg cgtcattatg aacagggtag
     6301 ttggcggcat tacgacacgc ccttctcgcg agggcaggtg ggtatcccca ttaacggact
     6361 gatctggatg ggcgattata agtacatgct ggaacaggta gaggaaaaga tgaaggaggg
     6421 ctttcgctgc gtcaagctga agatcggcgc tatcgatttc gaccgggaac tctctttatt
     6481 gaaacacatc cgtgcgcatt tctctgccaa ggaaatagag cttcgggtag acgccaacgg
     6541 cgctttcctc ccctcggagg cgatggacaa actgaagcgg ctcgccgaga tggacttgca
     6601 ttccatcgag cagcctatcc gtgccgggca gttggaagag atggcacgcc ttgcggcaga
     6661 atcacccctt cccgtcgctc tcgacgagga actgattagc tgtaacgccc cggacgagaa
     6721 acagcggttg ttggaaacga tccatcccca atacattata ttaaagcctt ccctccacgg
     6781 aggtatctcc ggatgtacgg aatggattca cttagcggaa actatcttag ggagtacccc
     6841 tgaacaacct aaatggtggg tcacctccgc tctggaatcg caaatcggac tgaacgctat
     6901 cgcccaatgg tgcgccacgc taggtaaccc gctaccgcaa ggtctgggaa ccggcgagat
     6961 tttcaaggac gataaacata cgttgatcca acgaaaagga gacaccatct ggttcaccaa
     7021 cgacctttga cctatgccga tacaagaaga tttacaggca ttcttagctg aatggcacga
     7081 tccctcccct tttctggaag tccagacctc tggctccacc ggtacgccca agcggatgcg
     7141 agtacgcaag gaccggatgc tgaacagcgc ccggcttacc tgcgattatt tggggcttaa
     7201 gaagggcgac aaggccttgt tatgtatgcc cctacgctat atagccggaa agatgatggt
     7261 agtccgctcc ctatacgccg gactggatct ggaggtgtgc gaaccctccg gacacccgtt
     7321 ggcggattgg ggggatacgc ccctgcgctt tgccgccatg attcctttgc aggtttacaa
     7381 tacgttgcga gtacccgagg aacgtaaacg gctggagcaa acggatatct tgatcatcgg
     7441 cggcggggcg atcgacgcgg ccttggaaca ggagatacgg cagatgccaa acacggttta
     7501 ttccacctac ggaatgacgg agacgctgtc tcacgtcgcc ctgcgccggt tgaacgggcc
     7561 ggaagcctcg ccctattacc atcccttccc ctcggtgacg ttatccttgt caccggacaa
     7621 taccttggta atagacgccc cattggtttg cgacgagcgg ctggtgacga acgatgtcgc
     7681 ccgcctgctg ccggacggga gtttcgccat tatcggaagg aaagataata ttatcaatag
     7741 cggaggtatc aagatccaga tcgaggaggt ggaagagcgg ttacggccct acctcgaccg
     7801 cccctatgcc atcaccgccg cccccgaccc tcgattggga gaggcggtcg tgctactgct
     7861 tgcctcaaac ctacgaggtg agatgctaac agaggttctc gccagcctgc ccaagtacct
     7921 ccgtccgagg cacatcataa aggtaagcga gatcccccaa accggaagcg gcaagatcga
     7981 ccgtgccgcc tgccgggagc tagcgagaaa tatcattaca aaaacactat aaacatgaaa
     8041 agaattctaa caatcaccgc ggtctcccta ttggccttat cgcctatgta cgggcaggat
     8101 tcttgccgat acccgcaaga tcctaccttg gagaaatcgc aagcctatgc aggatacgac
     8161 tgcgtcacct tgctggatag caccgccgtt acggtacaac ctaccggctc gggggctttc
     8221 gccgtatgca aggcttttaa ggtacagact tccaaaggag ccgtcgccaa ccgtatcatc
     8281 aaatacgatt acgacccgct gacggcgcac gccgagtttc gttacgccac gatctaccgt
     8341 gcgaacggcg acgtgatcaa tctcgacgta acccaagctt gcgactacgc cgcccccgca
     8401 cgtgccatct actggggcgc ccggcagatc atgctggaag tgggccgctt gcaaccggga
     8461 gatatcgtgg agtacgagat cgccaagaaa ggtttcacct acgccttgct gacggcgggt
     8521 gacgacgacg agcgtttcat ccctcctatg cgaggacagt tttacgatat cgtccccttc
     8581 tgggctaccg agcctaccgt gcgcaaggtg taccgggtat ccatgccgat ggagaaagag
     8641 ttgcaattcc agttctacca aggcgaatgt acctcttcga tgcgatacga ggacagacgg
     8701 aaagtatata ccttcgcctc cgacgatatc cttcctttcg ccaaggaacc gaacatggta
     8761 gacctattcg acgctgcccc gaagctcatg atgtccagta ctccccgctg ggaggataaa
     8821 tccctttggt tcaataaggt taacgaggat tacggaagct ttactgcgat cccggaagcc
     8881 cagaaaaagg tagacgagct gatcaaaggc aagaaaacgg aaatggagaa gatagccgtg
     8941 ctgacccact gggtggccga taacatccgt tactccggaa tctcgatggg taaaggcgag
     9001 ggtttcacgc ttcacaacct gaaaatgaat tataccgatc gttgcggtgt ctgcaaggat
     9061 atcgccggta cgttgatcgc cttcctccgc atggccggct tcgaggctta cccggcgatg
     9121 accatggcgg gaagccgtgt agaaagcatc cccgccgacc atttcaacca ttgcgtggcg
     9181 gtggtaaaac tggctagcgg cacgtatatg cctctcgacc cgacttgggt tcctttctgc
     9241 cgggaattat ggagtagcgc cgagcaacag cagaactacc tcccgggtgt gcccgaaggc
     9301 tccgacctcc gcttaacccc tgtctccgcc ccggagaacc actacgtccg catccacgcc
     9361 gacaaccgcc tagacgagaa aggcacgctc cgcggacaat tcacgatcac cgccgaggga
     9421 caatccgaca gcaatatccg ccgcatcttc accaccggat ggcaatccga ctggcagaac
     9481 acgatggaga agcaattgct ggccgtatcc cccaacgcca aactgcttcg tgtagattac
     9541 ggtaaggacc cgaagaacta tcaagcggcc cctatcaaga tcacgttctc ttatgagatc
     9601 cccgattacg cgatcatcgc cggagaccag atgcttatca agccgctagt catgaataac
     9661 ctctacaatc aagtgaagag tttcttgcgt atcgatacga aaccggaaaa ccgtgcgtat
     9721 ggattcaagg atgcttgctc ccgtttggta gaacaagatg agaccatccg cctccccaag
     9781 ggctataccc tcttgaacgc cccgaagaat gacgtcctgc aaagcaatgc ggccgatttc
     9841 gaaggttccc tttcgcagga aggcaatcag aacatcgtct tgcgccagaa gctagcgttg
     9901 aagaagcgtg tctacgacgc agccgactgg aaaggtttcc gttccgccgt gaacgcttat
     9961 aagagttatg gtgactattt gattatcaag aaataaaaac agaaagacaa tgattaagat
    10021 aacctataaa ctgattcttc tcctaggctt gttagcgatg acggttactt cattcgccgc
    10081 atcggaggct gagtacggga aggtatcgaa agcttggacc ttgcatgccg acggtagcca
    10141 agaataccga tcctccatgg aattgacgct cttcacgcac actgcgatga atagcacgta
    10201 tggcgagagt tttatcgtct acaatcccga tttccaaaca ctgaagatcc actcatccta
    10261 tacaaggcag aaagacggta cgatcgtaaa gacacccgat aacgcctttg tagaggtcct
    10321 accccgtttc gccgccgacg ctccggccta taaccaactc aaggaaatgg tcgtggtaca
    10381 cactggccta gaacttgggg ccacgattta cttggattac tctattatca caaaaccggg
    10441 ctactatccg gctatggata tcaacgagcg actacaagag acttctcccg tgaaggaatg
    10501 caaggtctct atctccgtac cggaaaacag tccgctcgct tggcaattat tgggtagcga
    10561 cgcgaaagca tcccaagcca cccgaaacgg cgctaaagag gtaagctgga ctttacgtaa
    10621 cctgccggcc tcttcccggg aagctttcct tcctcaaaac caagacggga ttccccgcct
    10681 aatcgcttca agctatagtt ccaacaagga ggcattatct acgctaaata agcgttttaa
    10741 cacttccgga aactacgaga gcaaaacgtt cggctcttat atcacggaaa aggctactag
    10801 cgacgaagag aaggtgaacg ccatccggaa ccatgtagtc aacaacatgg gatattgcgc
    10861 catccccctc gcttgtacgg gttattccat ccgcgatgtc gatacggccc ttcgcagtgc
    10921 ttacggtaca ttagccgaga agacccagct tctgaacgtc ttattgaacg ccgccggcat
    10981 tcaatcggaa gtagtcgccg tatatccagg gaatctggat atagacgctt gtggattaag
    11041 cacgatcaag aatcttgccg taaaagcgac tgtcgcaggg aaagacaaat acctttcggc
    11101 ggtcagcctt gccccttccg cattaacagc ccggggtgag ttagatcagg tactcacgtt
    11161 gaacggcacg tcgatcgccc tacaggcaga gcctacgatc atcaaggaga ataaagccgt
    11221 cagcgtctcc aagaacgaag cacaaaacgg attcgccatc tgtacccttc cggctataac
    11281 aggcggtatc gatagctggg gcatgagcgc tttgaacagc aagcgttcca acttattcga
    11341 actcccctcc ctgatcaagg aagaggtaac ctacacggtt actcccgccg agggcatgaa
    11401 gttgcagacc tccacaaaag agcaagtgat aagtaagcct tttggtaaag taacccgcac
    11461 gatcacacca agaggaaata cgatcgaggt agtacgtacg atcgagttgg acaagcaaca
    11521 gttcactccc gccgaatata gcgacgtgcg tagcttgatc catgaatgga caaatccgga
    11581 taaccgggta ttgctattct ccctataaga tctaaatacg gagggcacgg aacacacgaa
    11641 tatccacgga tataaggaaa tatcatttct atccatggaa atctgtgtat tccgtgtgct
    11701 ctgtgtctaa ttatttcata catttacgaa cgttaacatt aaatcatatc gtatatgaag
    11761 acactaaagt atttactcgc caccatgctc cttctaggcg tttgtaacct aacgcatagc
    11821 caaaagctat ccctaggaat cttccccgag ccccaagagg tgactatttc cagccaaaca
    11881 tacacaccgc cccatggata taccctacgg ggtataaata atccggacgc agatgcggtc
    11941 aaactactta aagaagcgct acctttcgct aaatccggca aatctctccc tttagagatc
    12001 aagaaactaa aagacaaaac tccagaaatg caacgatcgg gggcctacac actagcaatc
    12061 actaaaaaag gtatcacgat cgggatcgta gacgataatt ccttgtttta cgccgcccaa
    12121 accctcaagc aattagctaa atatgacgag ggtaaaaaga tcctgcctct ctgctcgatc
    12181 aaagactatc cggacgtatt attccggggt accgtggaag gattctacgg acagccttgg
    12241 agccacgccg accgtatcga gcaaatccgc ttttacggaa ggatcaagct aaacacttat
    12301 ctctatggtc cgaaagatga tccttatcat agttctccca actggcgcaa accttatccc
    12361 gccgaggaag ccgagcatat caaggaacta gcgaaagagg ccgcccataa caaagtaaac
    12421 ttcgtttggg ccatccatcc gggacaagat attcaatggg accaggcgga cagcatgaac
    12481 atcctttcca aattcgagaa aatgtacgat ttgggcgtac gctctttcgc cgttttcttc
    12541 gatgatatat ccggagaggg agcccgcccg gaaaagcaag ccggcttatt gaattacatc
    12601 cataaggaat ttatcagcaa gaaaaatgac gtgcaacccc tgatcatgtg ccctaccgaa
    12661 tacaaccgtt catgggctaa gaccgactat ctggatatcc tcggtaccca actcgatccc
    12721 gccatccaaa tcatgtggac cggagaccgt gtcgtagccg atatcacgaa agaaggcgtc
    12781 gaatgggtaa acaaccgtat ccgtcgtccc gcctatatct ggtggaactt ccccgtaagc
    12841 gattattgcc aagatcattt gttgatggga gccgcctacg gcctagatac gcaagccgcc
    12901 ggcaccatga ccggattcgt atccaatcct atggaatatg ccgaggcttc caaggtcgct
    12961 atattcggcg ttggaatgta cacttggaat atcaagaatt acgatcctac acaggcatgg
    13021 aaagacgctt gcgactttat tatgccggag gcctccatgg ctttccgcat tttctgcgag
    13081 cataactgcg atccgggtcc gaacggacat caataccgcc gggaagagtc tgctaactat
    13141 gtggctccta tccagacatt ccttaccgga tataagaaaa acacgttccc ggagcaaagc
    13201 gcaaatcttc tgggaacctt attcgctcaa atcacggctt ccccaagcat gatctacagc
    13261 caaagtccca ataaacgctt gatcgaacaa atcaatccat ggcttatcca attcgagttc
    13321 ttaggaaaag ccggtacaag tgctctgcat atggcgcacg cttggtatga gaaagaccgg
    13381 tcttatacat ggcaacgcta tctggaaaca tctgccttgc tagatagcat gaaactgata
    13441 aaccgcacgc tgaaccagaa ggcacagcct aaaggcgtga aagtcggatc gaaagtctta
    13501 caccctttca tcgtagactt atatcgtcag acaggtcgta acctgctatc tacggacggt
    13561 atcgccccgg acgaggtgaa ggttagcatc ccttccatat tcacgaatat cgaccaatta
    13621 aagagccagc cttgtgccga gggtgacaat acggtcggtt acgttcccct attcgaggta
    13681 gtcaaggtac aacctaacca atatctgggt atcggctggg aaatccagaa agaagcggaa
    13741 tccttctgtt tcaatcttcc gaaaagcaac caacccggac gggtattcga gtggtctgct
    13801 gacggaaaga gctggagcct aatcccccat gtctccacgg aaaacgctaa ggatacgatc
    13861 tgcgccatcg atccgaaagc ccgttatatc cgtatgcgaa ataactcgga tcagcaaatg
    13921 gagctatatg tactaggatt cacggcgaca accaaacaag acccgcaaat caatgaggct
    13981 cttatgatgt acgatatgaa cctagatacg tataagaact tgaatccggg agaaataatt
    14041 cacataaaat gcgatgatat caacgccgta tctttcttcc tctccggaag taacgagaat
    14101 ttggtatcta tcaccggcct ctctcaagat ggtgagaaaa acatcgtcta tcaagggaac
    14161 gtaggctaca tcaaattaaa taaaaccatg ttcgaggatt tctcttcttt agaaatcacc
    14221 acaataggaa aagaacctat acatatccac cagatcgtta gggaat
//
