LOCUS       c00181_gnlPro..         5142 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|ILMFHNKP_181.
ACCESSION   c00181_gnlPro..
VERSION     c00181_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 10:00:53
            Original ID  :: gnl|Prokka|ILMFHNKP_181
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5142
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..5142
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[965:5064]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      966..5064
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..5142
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..5142
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             352..588
                     /locus_tag="ctg181_1"
                     /transl_table=11
                     /translation="MTKLSNIPAKETTAKTAKTRKTKTGPAKLKWDPTKPVQFTQEEIW
                     EHIHEIEKGPFLTLDEGFKRFEAWKQDLLKSRL"
     CDS             555..896
                     /locus_tag="ctg181_2"
                     /transl_table=11
                     /translation="MEARPTQKQVITSSLFWESYDNVYVQGLDLFGFYQAELYANKIKS
                     ILYELDQTYPYYPECRHLATKSRMYRNIILDSHLIIYRITEERIEVLDIVHSASSMRKI
                     KKTRNIHIE"
     CDS             complement(966..2009)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg181_3"
                     /sec_met_domain="IlvN (E-value: 9.7e-48, bitscore: 150.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 1.3e-40, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYDKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(2059..2784)
                     /locus_tag="ctg181_4"
                     /transl_table=11
                     /translation="MEKVGLFHFVAEPYLMDFRGRVTLPMIGNYLIHAASSHAGERGFG
                     FNDMSERHTAWVLSRLAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFG
                     FARSIWAAIDVETRRPTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSD
                     LDINGHFNSVKYIEHLLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQ
                     DMAICHEGKAICRAAVTWR"
     CDS             complement(2791..3345)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg181_5"
                     /sec_met_domain="ALS_ss_C (E-value: 1.6e-17, bitscore:
                     52.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNEACVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             complement(3361..5064)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg181_6"
                     /sec_met_domain="TPP_enzyme_C (E-value: 4e-51, bitscore:
                     161.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYKKVDYVRSYQPEPDIKKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELRAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIAGRAVE
                     KREELDDAIAEMLNHDGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
ORIGIN
        1 taacattata tatctatcac acatcatcat atgattttca tatactcttt taatgtataa
       61 gacgtagtaa atataagaaa taaaaaaata tgtaataaag acctgcacac cccacacccc
      121 aaaattcatg cttattgtgc gtatatagca gataagcgat taaaaatagc ggttatgtga
      181 cataaataaa tttgaatacc attttgaggg gatggagacg gggcacgccc cgtctctaca
      241 actgggtaat gagttaatcc tatagaccta cttttttcct taccaaatat cttattacat
      301 ggaaattatt ccatacattt gccacagtac taattaataa cgattacgac tatgacaaaa
      361 ttaagcaaca tccccgccaa ggaaactacg gccaagaccg caaagacacg taagaccaag
      421 accggacccg caaagctcaa gtgggatccc accaagccgg tgcaattcac ccaagaagag
      481 atctgggaac atatccatga gattgagaag ggaccgttcc taaccctaga tgaaggtttt
      541 aaacgttttg aggcatggaa gcaagaccta ctcaaaagca ggttataacc agtagtttat
      601 tttgggaaag ttacgataat gtatatgttc aaggccttga cttatttgga ttctaccaag
      661 cggaattata cgctaacaag ataaaatcca tcttatacga gttagaccaa acctatcctt
      721 attatcccga atgccgacac ctagccacga aaagccgcat gtaccggaac atcatcctag
      781 attcacacct tatcatctac cgcatcaccg aggaacgcat cgaggtgctg gacatcgtcc
      841 attcagcatc cagcatgcga aagatcaaga agactaggaa tatccacatc gaataacaca
      901 aagaaaggcg agccacccgt aagtgacccg cctctttttg ctgatatata aggattaaga
      961 ttggattagt tgttctccgg acgaagctta cgtacagtaa cagctgtctg ccacatctcg
     1021 ctctcgcgca atgccttcaa ttcagcctcc aatttctcac gataatccgg cttagagttt
     1081 gagtcgatag agatctgagc ctcgttaccg cattttacgt ttgcgtacaa tttctcgaca
     1141 accggcttga ttgcgtcgtg gaacggaccc atccagtcca aagcgccacg ctgggcggta
     1201 gtagagcagt tcgcgtacat ccagtccata ccattcttgg cgaataaagg catcaaggat
     1261 tgagtcaact cctcgaccgt ctcgttgaaa gcctcggaag gagtatgtcc attctcgcgc
     1321 aatacctcat actgggccaa caacaaacct tggatagcgc ccatcaagga accacgctca
     1381 ccagtcaaat cggaagtagc ctcacggatg aaagtcgtct cgaacaagta gccggaaccg
     1441 ataccgatac ccaacgccaa cgtacgatcc atcgccttgc cagtagcgtc ttgatagata
     1501 gcgaaagaag agttcaagcc acgaccctca aggaacatgg aacgcaaaga cgtaccagac
     1561 cccttcggag cgaccatgat cacgtcaata tccgcgggag gaacaacgcc cgtacgatcg
     1621 ttccaagtga tcgcaaaacc atgagagaaa tacagggcct tgccagctgt caaataaggc
     1681 ttcatcgtag gccatacaga cattacggca gcgtcggaca acaagcacat gatgatcgtg
     1741 gccttgtcgc aagcctcctc gataccgaac agagtctcac ccggaaccca tccgtcctca
     1801 accgctttat cgtaagtctt accttggcgc tggccaacga ttacgttgaa gccattgtca
     1861 cgaaggttca atgactgtcc cggtccctgt acgccatagc cgataacagc gattgtctca
     1921 tcttttaata tctctcttgc cttttccaac ggaaattcct cgcgggtcat tacattctct
     1981 acaacaccgc caaaattcat ttgtgccatt ttctttttaa ctattaatgt ttaaaaacct
     2041 atttatgtat ctcttttatt atctccaagt aaccgccgca cgacagatcg cctttccctc
     2101 atggcaaata gccatgtctt gcttatcggg agcggactcc gccttatgaa gcgtaagcgg
     2161 cataccttgt ttaccctcgg attggtaggc gatctccaga cggccgatct cacgggtctt
     2221 gaactgatcg atatcgaaca aatccagcag gtgctcgata tacttcacgc tattgaagtg
     2281 accgttgata tccaagtcgc tgtatttgat cgaatacggg attccctccg ccttattctc
     2341 cgccggcatg atcttgcccg gcttctcgat cgggcacgga cgctcgtcga tatatttgcc
     2401 caatgcctct atatccaata aggtaggacg gcgggtctcc acgtcgatag ccgcccaaat
     2461 agaacgggcg aatccaaagg ttttcccatt ctcatccgcc agctcgaaac aacgactggt
     2521 gaagaggcgt ccgacctcat cgatccaagt gtatagatta atcttatcga aggcggtagg
     2581 atattccttc atctcgatag ccagacggga caacacccaa gccgtatgac gctccgacat
     2641 atcattgaaa ccgaacccac gctctccggc atggctggaa gcggcgtgaa tcaaatagtt
     2701 accaatcata gggagcgtta cacgtcccct gaaatccatc aaatacggct ccgccacgaa
     2761 atgaaataat cctactttct ccatatctta ttattgttgc ttttcatgta actttcgctc
     2821 catatcggcc aacatatcgc tcaagcgctc caccttgctc ttcgtgatag ccacacgtcc
     2881 ggagcggatg aattgcagga caccgatcgt ctcgctcaac tcattgaaca aggcttgtgt
     2941 ctcgtcatag tggccactct tctccaacac cacgcaggcc tcgttcatct ccaagatacg
     3001 agcgttgtat ttacggatca atccctccac ggttcccatc ttgatgaaaa gctcggtact
     3061 tagcttataa agggcgatct cttgataaac cagatcctca tccgtattat aataagcctt
     3121 caagatatcc acacgtttat cgatctgttt caccacctta tcgatcatat cctcatcggc
     3181 gaaggtcgtg atcgtaaact tatggatgcc cttgatagcg gacggagaga cggacagagt
     3241 ctcgatgttc agctgtcggc gtgtaaagat aatcgttatc tggttcaaaa gacctacgat
     3301 attctctgaa aagataataa cggtatataa tttctttgtt gtcatagctt catctcctcc
     3361 ttatttctcg tctcccataa tcatgtttgt cacgcttccc ccggcaggaa ccatcggata
     3421 taccattccg caagtctcca cgttagcgac caacacgtaa gcgccgtcgt ggtttagcat
     3481 ctcggcgata gcgtcgtcca attcctcccg cttttcaacg gcacggccag cgataccata
     3541 ggctttagcg atcgccacga aatccggatt ctccatgatg gtgtttgaat aacgctcgtg
     3601 gaagaacaat tcttgccact gacgtaccat acctaagaag ttattattaa gaatgataat
     3661 cttcacgttc agtttctcct gcatgatggt acccaattcc tgaatcgtca tctgcatacc
     3721 cccatcaccg gtaaagaagc agaccgtacg gtccggagcc ccgaacttag cgcccatagc
     3781 ggccggcaga ccaaatccca tcgtacctaa acctccggaa gtcaccacgc tacgggtttg
     3841 tttatatttg aaatagcgga cacccatcat ctggttctgc ccaacgtcgg tcaccaatac
     3901 agcgtcgtta ccggtcgcct cggaaacctt acggactacc tcgcccattt tcagttggcc
     3961 ctcggtcgga tacaattcct tctcgattac cttatcgtat tcctctttct cgtcccgatc
     4021 gaactcggca ttccattccg gacgtttacg ttcttccaac aacgccgtga tcatcggtat
     4081 cgtgtgcttg gcattaccca gcacctttac atctacgggg acgttcttac cgatttccga
     4141 gttgtcgata tccagatgga taatcttggc ttgcttagcg tatgtcttta aatcgccagt
     4201 cacacggtcg tcgaaacgca taccgatagc gatcaataca tcacactcat tcgttttccg
     4261 gttcggccct acgtttccat gcataccgag cattcccttg ttcaatggga aatcggttgg
     4321 caacgcagat aagcccaata ccgtagatcc ggcaggtata tcattctttt ggagaaacgc
     4381 tctcaattcc tcttccgcac cgcctaacaa tactccctgc ccgaccagac agaagggttt
     4441 cttcgcctca ttgattaaat cggcggcggc cttgatacga tcctttttga tatccggctc
     4501 cggctgataa ctacgtacgt aatctacctt cttatattca tagtccacca gccctacttg
     4561 cgcgtccttc gctaaatcca gcacaactgg acccggacgg cctgtagaag cgatataaaa
     4621 agcacgagaa acagcccatg cgatctcctc cggcttgcgg atttgataag cccatttcgt
     4681 gatcggttgc gtgatgccaa tcacgtcgac ttcctgaaaa gcatcggttc ccaacaacgg
     4741 cgagggtact tgaccggcga ttacgaccat tggcgtacta tccatcagcg catcagcgat
     4801 acccgtgatg gtattcgtag cgcccgggcc ggaagtaacc aacgtcactc ctaccttgcc
     4861 ggatacacgg gcatatcctt gagccgcatg ggtagcgcct tgctcgtggc gcaccaatac
     4921 atgcctcaac tggtccctat aatcatataa actgtcgtaa ataggtatcg cctgtccgcc
     4981 gggataaccg aagatagtat ctactccttc agcaatcaac gctttcagca aagcttccga
     5041 accggttatc ttttgtttct ccataagaaa taacgtgttt aatgtatatt attggcttta
     5101 atcttcaaca atccttacac ctcccttatc ggcggagcta ac
//
