LOCUS       c00086_gnlPro..        14643 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BBCBFNHI_86.
ACCESSION   c00086_gnlPro..
VERSION     c00086_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-07 16:48:24
            Original ID  :: gnl|Prokka|BBCBFNHI_86
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14643
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14643
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[3918:8627]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      3919..8627
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..14643
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14643
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(437..2287)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Alpha-amylase"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg86_1"
                     /sec_met_domain="Alpha-amylase (E-value: 1.9e-64, bitscore:
                     207.8, seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKVFLILGTLLLSLSTYAAMNVNKIDPPFWYTGMQNPELQLMVY
                     GEGIGNAAVSVNYPGVSLSSTVKLESNNYLLVYLKLDKDVKPGKFNLTFTEGKKKLVKE
                     YELKARNKKGCEHKGFDASDALYLLMPDRFANGNPDNDQIAGMAEYKIDRNDPNARHGG
                     DLAGIEQHLDYFSDLGVTALWFTPVLENNMTGGSYHGYATTDYYKVDPRFGTNEEYKQL
                     IEKAHARGIKIVMDMIFNHCGVEHVWIKDMPSKDWFNNPDHENNFVQTSFKLTPHVDPY
                     TSQYDADQMNDGWFVPSMPDLNQKNPHVYRYLVQNSFWWIEFANIDGIRMDTYPYADYD
                     AMSNWMKELNEEYPNYNTVGETWVTEPAYTAWWQKDSKLSAPKNSNLKTVMDFSFFDKI
                     NTAKNEQTETWFKGLDRIYNNFVYDFLYPNPASVLAFIENHDTDRFLGEGNNLPMLKQA
                     STLLLTTRRIPQLYYGTEVMMNGVKSKSDGYVRKDFPGGWTGDATNALTPAGRTKIQNE
                     CYDFYKTILNWRKGNDVIAKGSMVQFMVQNGVYAYARQYEGKTIFVMLNGTDAETTVPL
                     KFYKEILKNSKQGKDILSGKAITFGEELKMGPRESLVIEL"
     CDS             complement(2397..3749)
                     /locus_tag="ctg86_2"
                     /transl_table=11
                     /translation="MRKLFISLCFSACCSLLAAQTTNPIQEAMANYDYETALMLIDQET
                     PTVPLLYQKGKALKGLGNNLEALSVFQEVVAQDSLNPRAYIEAAECCKSLAKYSEALDY
                     YQNALHINPDNKYARIQYISLLMNMKRYRESLKESNLLAERDSSTYVLHLRAESMGQVY
                     DNTEIMHVIDAYLDIQKRYPNDYLSAAKLGNIYVAGHQYEDAINITEKYRSIDSTNVLV
                     NRINAQAYCLNKDYPKAIERYEQLLQEKDSSFQTCFYAGISYYALEDFYPAHDLLERAL
                     KDDNTNINVLYYLGRACSKTSWKEDGVTYLETAVSLAMPSDSVMSRLYVGLADCYKMAF
                     QYTDQANTLLTQYEKYDRQKHKLLYDAAFIYYYYLKDASKAERYLTAYLKTRPKNSKDK
                     VQEVDADGVPIIGEDNRYNAAENWLKDIREKRKKEDFFKGKVDTASVTPIK"
     CDS             complement(3919..5079)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_3"
                     /sec_met_domain="OAD_beta (E-value: 4.3e-153, bitscore:
                     498.9, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGEFITFLGNNLADFWTYTGFANATVGHVVMLLVGLFFIYLAVAK
                     EFEPMLLIPIGFGMLIGNIPFNMEAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLVGAAAQFGIFGAYMIALAIGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRWLTSKNERLIRMKPPRVVSHTEKVMFP
                     IIGLLLTTFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDTITILLGLTVGAS
                     TQASEFLTLDSIKIFGLGALSFVIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(5081..5515)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1024:Biotin-requiring enzyme (Score: 67.3; E-value:
                     2.7e-21)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_4"
                     /sec_met_domain="Biotin_lipoyl (E-value: 4.8e-22, bitscore:
                     67.3, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNVYKVAIGDIEDNIAHVEVNGTPYKVEMEKAPKVV
                     VKPVARPAATSAPAAPATPVVKPAAASTGKSGVKSPLPGVILDIKVNVGDTVKKGQVII
                     ILEAMKMENNINADKDGKITAINVNKGDSVLEGTDLVIIE"
     CDS             complement(5539..6471)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_5"
                     /sec_met_domain="OAD_gamma (E-value: 9.3e-18, bitscore:
                     54.3, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLMLVLGFCSSCKEQKSNNKLLLNEVLVNNESNYQ
                     DDYGVHSAWIEIFNRSYGSADLAGCYLKFSSQPGDTASYFIPKGDVLTLIKPRQHALFW
                     ADGEPRRGTFHTNFKLDATNANWIGLYDSGKKLLDQVIVPAGTLKANQSYARVSDAADQ
                     WEVKGGSEDKYVTPSTNNKTIDSNAKMEKFEEHDSVGIGMAISAMSVVFCGLILLYISF
                     KIIGKISVNLSKRNAMKAKGITDKQEAKEKQLGQAPGEVFAAISMAMHEFQSDVHDVED
                     TILTITRVKRSYSPWSSKIYTLRETPHKK"
     CDS             complement(6503..8056)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_6"
                     /sec_met_domain="CT_Btheta (E-value: 1.1e-291, bitscore:
                     956.9, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIDRRAAARLGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYIFAQDFTVSAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAQTEEEGLALIRKLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDNPN
                     KPYDMYEVIGAIIDNGEFLEIQKDYSKNIIIGFARFNGQSVGIVANQPKYLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKEQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRIIRALQQLQTKKLTNPAKKHGNIPL
                     "
     CDS             complement(8115..8627)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg86_7"
                     /sec_met_domain="Glyoxalase_4 (E-value: 3.6e-26, bitscore:
                     81.2, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNFFIKEEFSFFVLLYTFIKKDTILTLIYIVMKISHIEHLGIAV
                     KSIEEALPYYENVLGLKCYNIETVEDQKVRTAFLKVGDVKIELLEPTSPESTIAKFIEK
                     NNGNGGMHHLAFAVEDGVAGALAEVEEKGIRLIDKAPRKGAEGLNIAFLHPKSTLGVLT
                     ELCEKPE"
     CDS             8821..10308
                     /locus_tag="ctg86_8"
                     /transl_table=11
                     /translation="MKKNILLAVCFLMPLATMAQNDTLGHERNITLSEAIVLARTQSVD
                     AAVALNELKTAYWEYRTFRADLLPEVNFTGTLPNYNKSYSTYQNSDGSYSFVRNNTLGL
                     SGQLSVDQNIWFTGGKLSLTSSLDYLKQLGSGGAKQFMSVPVSLELTQPVFGVNTLKWN
                     RRIEPVRYAEAKAEFISATEEVTMKTITYFFELLLAKESLATAMQNKTNADRLYEVAIA
                     KRKMGQISENDLLQLKLNSLQGKADVTEAESNLNAKMFQLRSFLGVSEQESLNPVLPAT
                     VPDIKMEYDRVLNKALERNSFAQNIRRRQLEADYEVATARGNLRSIDLFASVGYTGQNH
                     EFSSAYRDLLDNQIVQVGVKIPILDWGKRRGKVRVAKSNREVVLSRIRQEQMDFNQDIF
                     LLVANFNNQAQQLDIAEEADVIAEKRYKTSVETFMIGKISTLDLNDAQNSKDEARQKHI
                     SELYYYWYYFYQLRSLTLWDFERDTELEADFEEVVRG"
     CDS             10452..11813
                     /locus_tag="ctg86_9"
                     /transl_table=11
                     /translation="MILIIDDDSAVRSSLSFMLKRAGYEVKTAPGPREAMDIVRAEAPA
                     LILMDMNFTLSTTGEEGLTLLKQVKVFRPDVPVILMTAWGSIQLAVQGMQAGAFDFITK
                     PWNNAALLQRIETALELTAAPKEVPEEQTTALNRSYIIGKSKGLMEVLNTVARIARTNA
                     SVLITGESGTGKELIAEAIHINSQRVKQPFVKVNLGGISQSLFESEMFGHKKGAFTDAS
                     ADRIGRFEMANKGTIFLDEIGDLDPSCQVKLLRVLQDQTFEVLGDSRPRKVDVRVVSAT
                     NADLRKMVSERTFREDLFYRINLITVKLPSLRERREDIPLLARHFADRQAEVNGLPRTD
                     FSADALNFLSRLPYPGNIRELKNLVERTILVSGKPVLDATDFDAQYLRHDEPAKVAEGT
                     SFAGMTLDEIERQTILQALEQHKGNLSQVAVSLGISRAALYRRLEKYNIQVPCA"
     CDS             11804..13117
                     /locus_tag="ctg86_10"
                     /transl_table=11
                     /translation="VRIKFFFFILVLFLLGLGGMLVYLLSGKPLLYLYVLEGLIGFILI
                     YLIVFYNKIVKPMNTIGSGMELLREQDFSSRLSRVGQYEADRIVNIFNRMMEQLKNERL
                     RMREQNHFLDLLIQASPMGVIILTMDDEVSQLNPMAVKMLGVRMEEAMAKRLDQMDSPL
                     AAELSSIPKDETAVVRLNDANIYKCTHSSFIDRGFKHPFFLIERMTEEVMRAEKRAYEK
                     VIRMIAHEVNNTTAGITSTLDTVEQALSTEDDMEDICDVMRVCTERCFSMSRFITRFAD
                     VVKIPEPTLVPVQLNELVSMCKRFMEGMCNDRNIELRLECDPEVGMVRMDASLFEQVLV
                     NIIKNAAESIEGDAGENGQQGEIIVRTTAPASVEVVDNGPGISKETEAKLFSPFFSTKP
                     NGQGIGLVFIREVLSRHGCTFSLRTYNDGLTRFRILFN"
     CDS             complement(13151..14641)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GlcNAc_2-epim"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg86_11"
                     /sec_met_domain="Aminotran_1_2 (E-value: 8.3e-23, bitscore:
                     70.6, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="GlcNAc_2-epim (E-value: 0.00011, bitscore:
                     11.1, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="ATAPREAFFLLGSFGLEECRRIMDLPEGIAGIPEKKGIASHFEAF
                     LKKNNNVSGAKLLEQTYNYLLMQHAADPDSLVHEWAESIVGDQYPVPDRILHFTEILVQ
                     DYLSQEMCDNRPPRGAYDLFATEGGTAAMCYIFDSLQENFLLNKGDGIVLMVPAFTPYI
                     EIPQLSRYQFRVTKIHANRMNSEGMHLWQYSDEDIDRLKSPKIKALFVTNPSNPPSYTL
                     SPDTMARIVSIVRNDNPNLMIITDDVYGTFSPHFRSFMAEIPYNTLCVYSFSKYFGATG
                     WRNAVIALHEFNLFDKLIAKLPKEKREILHHRYSTLTLEPERLKFIDRMVADSRQVALN
                     HTAGLSLPQQMQMGLFAAFALLDKENKYKQKMQEIIHRRLHALWENTGFTLTEDPLRVG
                     YYTEIDMLVWAKKFYGDDFVEYLKRTYSPLNVVFRLAKETSLVLLNGGGFDGPEWSVRA
                     SLANLDEKDYATIGRGIKKILEEYAKEFFKNGKAKGKN"
ORIGIN
        1 caatattgat gttgcaaggg ctgacttgtt gtatataggc cggtgttgtg ggatggttaa
       61 gttcgccggt tatttcagaa gcggatgttt caacgtgtac aacagtctgt ttcctttaac
      121 aaaacagtct gtttccctta actgaacagt ttgtttcaat aaagagaaca cttcgttcca
      181 atatgcaaaa acacttcgtt ccaatacgta agaacacttt gtttctacat atctgaacac
      241 tttgtttctc tatactggaa caaagtgttc actgttatga actaacagat tagctatatt
      301 tgaggccggt gaaaggcata tccccgtgac acctgttcca tactaaaaat cccttgcaga
      361 tggctggcag gagaagtgtc tgccagctat ctgcaaggga gatttgcaag aatgagctct
      421 ctgtgtggag tacgcgttat aattctatca ctaatgattc tctggggccc atcttcagct
      481 cttcaccgaa ggtgatggcc ttgccgctaa gaatatcttt tccctgcttg ctgtttttca
      541 ggatttcctt gtagaatttc aaaggaacgg tggtctctgc atctgtaccg ttcagcatca
      601 cgaatatcgt cttgccttcg tactggcgtg cgtaggcata aacaccattc tgtaccatga
      661 actgcaccat gctgcctttg gcaatcacat cgtttccttt gcgccagttc aggatggtct
      721 tgtagaagtc gtagcactcg ttctgtattt tggtacgtcc ggctggggtc agtgcgtttg
      781 ttgcgtcacc ggtccatcca ccggggaagt ccttgcggac atagccgtcg ctcttgctct
      841 tcacgccatt catcataact tccgttccgt agtagagttg cggaatgcgg cgggtggtaa
      901 gcagcagggt agaggcttgc ttcagcattg gaaggttgtt gccttcgccc aggaagcggt
      961 cggtgtcgtg gttttcgatg aatgccagta cggaagcggg gttggggtag agaaagtcgt
     1021 atacgaagtt attgtatatg cggtccagtc ccttgaacca agtttcggtc tgttcattct
     1081 tggcggtgtt tatcttgtcg aagaagctga agtccataac ggtcttgagg ttactgttct
     1141 tgggggctga tagcttggaa tccttctgcc accaggcggt gtaggcgggt tcggtaaccc
     1201 aggtctcgcc cacggtgttg tagttgggat attcttcgtt gagctctttc atccagttgc
     1261 tcatggcatc atagtcggca tacgggtaag tgtccatgcg gatgccgtcg atgttggcga
     1321 attcaatcca ccagaaactg ttctgtacca ggtagcggta aacgtgaggg ttcttctggt
     1381 tgaggtcggg catggaaggt acgaaccagc cgtcgttcat ctggtcggca tcgtactggg
     1441 aagtataagg gtctacgtgc ggggtcagtt tgaaggaggt ctgcacgaag ttgttttcgt
     1501 ggtcggggtt gttgaaccaa tctttggagg gcatgtcctt aatccataca tgctctacgc
     1561 cgcagtggtt gaaaatcatg tccattacga ttttgatgcc gcgtgcatgg gctttttcaa
     1621 tcagttgctt gtattcttcg ttggtaccga agcgcgggtc taccttgtag tagtctgtgg
     1681 tggcatagcc gtgataggaa ccgccggtca tgttgttttc cagtaccgga gtaaaccaga
     1741 gggctgtgac gccgaggtcg gagaagtagt ccaggtgttg ttcgatgccg gcaaggtcac
     1801 cgccgtggcg tgcattgggg tcattgcggt ctatcttgta ctcggccatg cccgcaatct
     1861 ggtcattgtc cggattgcca ttggcaaagc ggtcgggcat cagcaggtac agtgcgtcgg
     1921 aggcgtcgaa acctttatgt tcgcaacctt tcttgttgcg tgccttcagt tcatattcct
     1981 ttacgagttt cttttttcct tcagtgaagg tgaggttgaa tttgccgggt tttacatcct
     2041 tgtccagttt cagatagacc aggaggtagt tgttgctttc cagcttgacg gtgctgctca
     2101 atgagacgcc gggataattg acggatactg ccgcgttgcc gatgccttcg ccatagacca
     2161 tcagctggag ttccgggttc tgcatgccgg tgtaccaaaa cggagggtcg attttgttca
     2221 cattcatagc tgcatacgta ctgagggaga gtaagagtgt tcccaagatt aagaatactt
     2281 ttttcatgat agtaacttta cggttaattt ttgcgctaat ttaaaacaaa taacggagaa
     2341 agttaatctt tctccgttac tgtactttat tatattatgc aaacgttttc attgggctat
     2401 ttgatggggg ttacgctggc ggtatcgacc tttcccttga agaagtcctc tttcttgcgc
     2461 ttttctctga tgtccttcag ccagttttcg gcggcattgt atcggttgtc ttctccgatg
     2521 atgggaactc cgtccgcatc tacttcctgc actttgtcct tgctgttttt cggacgggtt
     2581 ttcaggtagg ccgttaggta tctctctgct ttggacgcat ctttcagata gtaataatag
     2641 ataaaggctg cgtcgtagag cagtttgtgt ttctgccggt cgtatttttc gtattgtgtc
     2701 agaagggtat tcgcctggtc ggtgtattga aatgccatct tgtagcagtc cgcaagcccc
     2761 acatataggc gggacatgac actgtcgctg ggcatggcga ggcttacggc agtttccaga
     2821 taagtcactc catcctcttt ccatgatgtc ttggagcagg cgcgtcccag ataatagaga
     2881 acgttgatgt tggtattgtc atctttaaga gccctttcca gcaggtcgtg tgctgggtag
     2941 aagtcttcga gggcataata gctgattccg gcgtagaagc aggtttggaa agaactgtct
     3001 ttttcctgta acagttgttc atatctttct attgctttgg ggtaatcttt gttcaggcaa
     3061 taggcttggg cattgatgcg gttcacaagg acgttggtgg agtctatgga acggtatttc
     3121 tccgttatgt ttatggcgtc ttcatactgg tggcctgcta catagatgtt gccgagtttg
     3181 gcagcagaca ggtaatcatt gggatacctt ttctgtatgt ccaggtaggc atctatcaca
     3241 tgcatgattt ctgtgttgtc atagacttgc cccatacttt cggctctaag gtgtagtaca
     3301 taggtggaac tgtccctttc tgccagcagg ttactttcct ttagagactc acggtatctc
     3361 ttcatgttca tcagcagact gatatactga atgcgtgcgt atttattgtc cggatttatg
     3421 tggagcgcat tctggtagta atccagtgcc tcgctatatt tggcaagtga tttgcagcat
     3481 tcggcagctt caatgtatgc ccggggattg agagaatcct gagctacgac ttcctgaaat
     3541 acgctcagag cttcaaggtt attgcccagc cctttcagcg ctttcccttt ttggtagagt
     3601 agggggacgg tcggggtttc ttgatcgatc agcatcaagg ctgtttcata atcgtagttg
     3661 gccatcgcct cttgaatggg atttgtggtc tgtgccgcca gaagcgaaca gcatgcactg
     3721 aaacataagg agataaaaag ctttcgcata cagtatatca tttatatgag gttaaactga
     3781 ctgcaagtta ctaaaaagaa tgtatttacg aaataatcgt aatctgtttt agatagatta
     3841 acgaaaaagc ccctccaaaa atgaaggggc tctaaaatag ttcagaattc aagccggata
     3901 acggaatgaa taaatgtatt acattaagaa tcccagcagg atacctgctg ctacagcgga
     3961 accgattaca ccggcaacgt tcgggcccat agcatgcatc agcagatagt tggtaggatc
     4021 gtattccaga cctactactt gggagatacg tgcagagtcg ggtacggcag atacaccggc
     4081 attaccgatc aacggattaa tcttgttgcc tttcttcagg aagaggttga aaatcttcac
     4141 gaagatgaca ccggatgctg tggcaatgac aaatgataag gcgcccagac cgaatatctt
     4201 gattgaatca agggttaaga actcggatgc ttgcgtagaa gcacctactg tcaaaccaag
     4261 cagaatagta atggtatcaa tcagcggacc actggctgtg tttgccagac gacgtgtaac
     4321 tccactttct ttcagtaaat taccgaagaa cagcataccc agcaaaggca gaccggatgg
     4381 tacaaggaat gtggttagta acaaaccgat aatcgggaac attacttttt ccgtatgtga
     4441 aaccacacgg ggaggtttca tacggataag acgttcattt ttactggtca gccaacgcat
     4501 aataggcggc tgtatcaccg gtactaatgc catatatgaa taggctgata ccgcaatggc
     4561 acccattaag ttaggagcca gtttggaaga gaggaagatg gcagtcggac catcggcacc
     4621 accaatgata ccgattgcac cagcctgcat cgggtcaaat cctatggcaa gggcaatcat
     4681 ataagcaccg aatataccga attgggctgc tgcaccaacc aacattaatt tggggttcga
     4741 tatcaaagcg gagaaatccg tcatggcacc gatacccagg aatatgagtg gcgggtacca
     4801 accggaggtt actccctggt acagaatatt aagtacggaa ccttcttcat agataccgac
     4861 tttcaatccg gcttccatat tgaaaggtat attaccaatc agcataccga aaccgatagg
     4921 aattaatagc atcggctcaa attccttggc tacagccaag tatatgaaaa acaaacctac
     4981 cagaagcatt accacatgtc ctaccgttgc attggcaaaa cctgtataag tccagaagtc
     5041 ggcaaggttg tttcctaaaa atgtgataaa ttctcccata ttattcaata attacgaggt
     5101 cagtaccttc gagaacagag tcccctttgt ttacattgat ggctgtaatc ttaccgtctt
     5161 tatcagcatt gatattgttt tccatcttca tggcttccag aatgatgata acttgtccct
     5221 tctttactgt atcgccgaca tttactttga tatcgaggat tacaccggga agcggagatt
     5281 ttacacctga cttgccggta gaagcagcgg ccggttttac taccggagta gcaggagcag
     5341 caggagcgga tgtggctgcc ggacgtgcta ccggtttaac gactaccttc ggtgcttttt
     5401 ccatttcaac tttgtaggga gtaccgttca cttctacgtg agcgatgttg tcttcaatat
     5461 ctccaatggc aactttatat acgttaccgt taattttata tttatattct ttcatcgttt
     5521 tattttatta tgggtgactt actttttgtg aggagtctca cgcaacgtat aaatctttga
     5581 actccacggt gagtaactgc gttttacacg ggtaatggta agtatcgtgt cttccacatc
     5641 gtgtacatcg ctttggaatt cgtgcatggc cattgaaatg gcagcaaaaa cttctcccgg
     5701 agcctgcccc agttgtttct cttttgcttc ttgtttatca gtaatacctt tagctttcat
     5761 ggcattgcgt ttgctgaggt taactgatat tttacctata atcttgaagg agatgtagag
     5821 taatatcagc ccgcagaata caacgctcat ggcagaaata gccataccga tacctacgct
     5881 gtcatgctct tcgaattttt ccattttggc attgctgtcg atagtcttgt tgttggtact
     5941 cggagtgaca tatttatctt cgcttccacc ctttacttcc cattggtcgg ctgcatcact
     6001 gacacgggca taggattggt tggcttttaa agtaccggca ggcactatga cttgatcaag
     6061 caatttcttg ccggaatcat acaacccaat ccagttggca tttgtggcat ccagtttgaa
     6121 gttcgtatga aatgtaccgc gtcttggttc tccatcagcc cagaaaagtg catgctgacg
     6181 tggttttatg agtgtcagaa cgtcaccttt gggaatgaaa taactggcag tatcacccgg
     6241 ctggctgctg aatttcagat agcaacctgc aaggtcggcg ctgccgtatg atctgttgaa
     6301 tatttcaatc catgcgctgt gcacaccgta gtcatcctga tagttgcttt cgttgttgac
     6361 cagcacttca ttcagcagca gtttgttgtt cgatttctgt tctttgcaag aagagcaaaa
     6421 gcccaacacc agcatcaatg aaaggaatat tccgattttt gttttattca taatcgttct
     6481 tgttttagtg tgaaaagctt gattacaagg gaatattacc atgcttctta gccgggttag
     6541 tcaatttctt ggtttgcaac tgttgcaggg cacgaatgat gcggaaacgt gtgttacgcg
     6601 gttcgataac atcatcaatg tagccatatt tagctgcatt ataaggattg gcaaacaact
     6661 tggtgtattc agcctctttt tcagccagga attgagccgg attttcctgc tctttggctt
     6721 cgcgggcata taatacttct acagcacctg caccacccat tacagcgatt tcagcagtag
     6781 gccaagcata attcatgtcg ccacgcagct gcttacagct catcacgatg tgcgaaccac
     6841 cgtaggattt acgcagtgtg atggtaacct tgggtacagt agcttcaccg tatgcataca
     6901 gcagtttggc accgtgcagg atgacgccgt tgtactcctg gccggttccc ggaaggaatc
     6961 ccggtacgtc taccaatgat acgataggaa tattgaaggc gtcgcagaaa cggacgaagc
     7021 gtgcgccctt gcgggatgcg ttgctgtcga gcacacctgc cagatacttc ggctggttgg
     7081 caacaatacc tacggactgt ccgttgaaac gtgcgaaacc aataatgata ttctttgaat
     7141 aatctttttg gatttcgagg aactcaccat tatctatgat agcgccaatt acctcgtaca
     7201 tatcgtacgg tttgttcggg ttatcaggaa tgatatcgtt cagggaatct tccagacggt
     7261 caatagggtc tgtacagtct acatagggag cttcttccag attgttctgg ggaatgtagc
     7321 tcaacagttt gcggataagg gccaaacctt cttcttctgt ctgtgcagta aaatgagtaa
     7381 caccagattt ggtggagtga acgctcgcgc cacccaggtt ttcctggctt acgtcttctc
     7441 cggttacagt ctttactacc ttcggaccgg taaggaacat gtaggatgta ccttccatca
     7501 tcaaagtaaa gtctgtcaag gcaggagagt aaacggcgcc accggcacaa ggaccgaaaa
     7561 taccggaaat ctgcggaatg acacccgaag caagtatgtt acgttggaag atttcagcgt
     7621 agccagccaa ggcattaata ccttcctgaa tacgtgcacc gcccgagtcg ttgataccga
     7681 tacacggagc acccattttc atggcttggt ccataatctt acagattttc agagacatgg
     7741 tttcggacag tgaaccggca gaaactgtga agtcctgtgc gaagatataa accagacggc
     7801 cttcgattgt accgcaaccg gttactacac cgtcaccggg gtagtgtttc ttttccatgc
     7861 cgaagttggt gcatctatgt tctacgaaca tgtccatttc ttcgaaactg ccttcgtcga
     7921 gaagcatggc tatgcgctcg cgagctgtat atttaccctt ctcgtgttgc tttgcaatcg
     7981 ctttttcacc accaccgaga cgtgctgcag cgcggcggtc tataagctct ttaatctttt
     8041 caagttgatt actcatgaat ttatattctt taagtgttta tacaatttat gatttgatga
     8101 ttttacagtc ttgcttattc cggtttctcg caaagctcgg tcaggacacc gagagttgac
     8161 ttcggatgca ggaatgcaat gttcagacct tctgcacctt tgcggggagc tttgtctata
     8221 aggcggatac ctttttcttc gacttcggca agcgcaccgg ccactccgtc ttcaacggcg
     8281 aatgcgagat gatgcatgcc accgttaccg ttgttctttt cgatgaactt ggcaattgtg
     8341 ctttcgggag aagtaggttc caacaattcg atctttacat cgcccacttt caggaaagcg
     8401 gttctaactt tctgatcttc cacggtttcg atgttgtagc atttcaaacc taaaacgttt
     8461 tcgtagtacg gaagggcttc ttcaatgctc ttaacggcaa tgcccagatg ctcaatgtgt
     8521 gaaatcttca taactatata aattaatgtt agtattgtat cctttttaat aaaggtataa
     8581 agcagcacaa agaaagagaa ttcttcctta ataaagaaat ttttcatcaa ttaattaatg
     8641 gttaattgaa ctttagaagg attttttcag actttagata gagaccggtt gttttcttga
     8701 tatcgtccgc taacggacat ccccactgtc cgaaaatgaa cacttacccc tctatgaaac
     8761 ctttccggcc acttggcaca ctctttgctt ttctgtttgc gacaatttta aagattgaac
     8821 atgaaaaaga atattttact tgcagtttgt tttttgatgc cgttggcaac catggcgcag
     8881 aatgatactt tgggacatga acgcaatatt acgctgtcgg aggccattgt actggcccgt
     8941 acgcagtctg tggatgctgc tgtggcattg aatgaattga aaaccgcgta ttgggaatac
     9001 cgtacattcc gtgcggactt gttgccggaa gtgaatttca ccggtacact acccaactat
     9061 aacaagtcct acagtaccta ccagaattcc gacggctcct atagctttgt tcgcaacaat
     9121 acactggggc tgtccggaca gctttcggta gaccagaaca tttggtttac ggggggtaag
     9181 ctgtcactga cttcttcgct ggattatctc aaacaactgg gttccggagg agcgaagcag
     9241 ttcatgtcag tccccgtgag tctggagttg acgcaaccgg tcttcggagt gaataccttg
     9301 aagtggaacc gccgtataga gcccgtacgc tatgccgagg caaaggccga gttcatttca
     9361 gctacggaag aggtgacgat gaaaaccatc acttatttct ttgagttgct gctggccaaa
     9421 gaatcgctcg ctaccgccat gcagaacaag acgaatgccg accgccttta tgaagtggcc
     9481 atagccaaac gtaaaatggg acagatatcc gagaatgatt tgttgcagct taaactgaat
     9541 tcattgcagg gcaaggccga cgtgactgag gcagagagca acctgaatgc aaaaatgttc
     9601 cagctccgtt ctttcctcgg ggtgtccgag caggaaagcc tgaatccggt gttgcccgcc
     9661 actgttcccg atataaagat ggagtatgac cgtgtgctga acaaggcact ggaacgcaac
     9721 tcctttgcac agaacattcg ccgccgccag ctcgaagctg attatgaagt ggcaacggca
     9781 cgcggaaact tgcgcagcat cgacctcttt gccagtgtgg gctatacggg gcagaaccat
     9841 gaattctctt cagcctaccg ggacttgctt gacaatcaga ttgtgcaggt aggcgtcaag
     9901 attcctatcc ttgactgggg caagcgccgc ggcaaggtaa gggtggcaaa gagcaaccgt
     9961 gaagtggtct tgtccagaat ccgtcaggaa cagatggact ttaaccagga catctttttg
    10021 ctggtggcta acttcaacaa ccaggcgcaa cagctggaca tagccgaaga ggcggatgtc
    10081 attgctgaga agcgttacaa gactagtgta gagaccttta tgataggtaa aatcagcacc
    10141 ctggacctga acgatgcaca gaactctaaa gacgaagccc gtcaaaagca tatttcagag
    10201 ctgtactact attggtatta cttctatcag ctccgcagct tgaccctttg ggattttgaa
    10261 cgcgatacgg aattggaagc tgattttgaa gaggtggtaa gaggataagt cgacgggttg
    10321 caagtgataa gttatgaatt atttgccggt aaaagtaccg tatatgcgat attataggta
    10381 aataacttat aacttatcat tcataactct gcttttttac ttatttttgc gggaaacaaa
    10441 ctacaatttt tatgatactg ataatagacg acgatagtgc tgtgcgctct tccctcagct
    10501 ttatgctgaa gcgtgccgga tatgaggtga aaacggctcc gggtcctcgc gaagctatgg
    10561 atatagttag ggccgaagct cccgctttga ttttgatgga tatgaacttc actctttcca
    10621 ctaccggaga agagggactt accttattga agcaggtaaa ggtgttccgt cccgatgtgc
    10681 ccgttatttt gatgacggca tggggaagta tccagcttgc cgtgcagggt atgcaggccg
    10741 gcgcattcga tttcataact aagccttgga acaatgctgc tcttttgcag cgcatcgaga
    10801 cggcccttga gcttacggcc gccccgaaag aggtgccgga agaacagact accgcattga
    10861 atcgcagcta tattataggt aagtccaaag ggttgatgga agtgttgaac acagtggccc
    10921 gcatagcccg taccaatgct tcggtgctga ttacgggcga aagcggaacg ggcaaggagc
    10981 tgattgccga agccatccat atcaacagcc aacgcgtgaa gcagcccttt gtcaaggtga
    11041 accttggtgg catctcgcag agcttgttcg agagcgagat gttcggccat aagaaagggg
    11101 cgtttaccga tgccagcgcc gaccgtatag ggcgttttga aatggcaaat aaaggtacta
    11161 tcttcctcga cgagattggt gacctcgacc cttcctgcca ggtgaaactg ctgcgcgtgc
    11221 ttcaagacca gacattcgaa gtgctgggcg atagccgtcc ccgcaaagtc gatgtacgcg
    11281 ttgtgtccgc cactaatgca gacctccgca agatggtgtc cgaacgtact ttccgtgaag
    11341 acctttttta ccgtatcaac ctgattaccg taaaactgcc ctccttgcgg gagcgccgtg
    11401 aagatattcc tttgctggca cgtcactttg ccgaccgtca ggcagaggtg aacggcttgc
    11461 cgcgtacgga tttctcggcc gacgctctga atttcctttc ccgcctgcct tatccgggca
    11521 acattcgtga gttgaagaat ctagtggagc gtaccattct ggtcagcggc aagccggtgc
    11581 tggatgccac ggatttcgat gcccaatatc tgcgtcacga cgaaccggcc aaagttgccg
    11641 aaggtacttc ttttgcaggt atgaccttgg atgaaataga gcggcagact atcttgcagg
    11701 cgttggaaca gcataaaggg aatctcagtc aggtggcagt gtcattaggc atcagccgcg
    11761 ctgcgcttta cagacgtttg gaaaaatata atattcaagt cccgtgcgca taaaattctt
    11821 tttcttcata cttgtccttt ttctgctcgg tctgggtgga atgttggtat atttactgag
    11881 tgggaagccg cttttgtatc tgtacgtatt ggaggggctc atcgggttta tccttatcta
    11941 tctgatagta ttctataata agatagtgaa gccgatgaac accataggca gcggtatgga
    12001 gttgctgcgc gagcaggatt tcagtagtcg tctcagccgg gtagggcagt acgaagcaga
    12061 ccgcattgtg aatatcttta accgaatgat ggagcagctc aagaatgaac ggttgcgcat
    12121 gcgcgagcag aatcacttct tggatttgct gattcaggca tctccaatgg gggttattat
    12181 cctgacaatg gacgatgaag tgtcgcaact gaatccgatg gcggtaaaga tgctcggtgt
    12241 ccgtatggag gaggcgatgg caaagcggct ggaccagatg gactccccgt tggctgccga
    12301 actttcgtcc attcccaaag acgagacggc agtggtccgt ctcaatgacg cgaatattta
    12361 taaatgcacc cattcttctt ttattgacag agggttcaaa catccttttt tcttgataga
    12421 gcgtatgaca gaagaagtga tgcgtgccga gaagcgtgcc tatgaaaagg taatccgcat
    12481 gatagctcat gaagtgaaca ataccactgc gggcatcact tccacactcg atacagtgga
    12541 gcaggcactt tctacagaag atgatatgga ggacatctgc gacgtgatgc gcgtctgtac
    12601 ggagcgttgt ttctcgatga gccgtttcat tacccgtttt gcagatgtgg taaagatacc
    12661 tgaacctacc ctggtgcccg tccaactgaa tgagttggtg tccatgtgca agcgttttat
    12721 ggaaggaatg tgcaatgacc gcaatataga gctacgtctg gaatgcgacc cggaggtggg
    12781 aatggtgcgt atggatgctt ctctttttga gcaggtgctt gtgaatatca tcaagaatgc
    12841 cgccgaaagt atagaggggg acgccggaga aaacggacag caaggtgaga taatagtaag
    12901 gaccactgcc cccgcttctg tcgaagtcgt tgacaatggt ccggggataa gtaaagagac
    12961 cgaagctaaa ctcttcagtc ccttcttttc caccaagccg aacgggcagg gaattggcct
    13021 ggtgtttatc cgggaagttt tgagccgtca tggttgcacg ttctccctac gtacctacaa
    13081 cgatggattg acccgcttcc gtatactatt taattgaaat ttgaaagttt tacctttcac
    13141 ctttcaattt tcaattttta cctttcgcct ttccattttt aaagaattct tttgcatact
    13201 cctccagtat ctttttaatg cctcggccga tggtcgcata gtctttctcg tccagattgg
    13261 cgagtgaggc gcgcacgctc cattcggggc cgtcaaaacc accgccgttc agcagcacca
    13321 gagaggtttc tttggcaagg cggaagacta cgttcagcgg gctgtaggtg cgtttcagat
    13381 attctacaaa gtcgtcccca tagaacttct ttgcccaaac cagcatgtcg atttctgtat
    13441 aataacctac gcgcaacggg tcttccgtca gcgtgaaacc ggtattctcc caaagggcat
    13501 gcaatcggcg gtggataatc tcctgcatct tttgcttgta tttgttttcc ttgtccagca
    13561 gggcaaaggc ggcgaaaagg cccatctgca tctgttgtgg caatgacagt ccggcggtat
    13621 ggttcagtgc cacctgacgg ctgtcggcaa ccatacggtc gataaacttc agtctttcag
    13681 gttccagagt gagggtggag tagcggtggt gcagaatctc ccgtttctct ttcggcagtt
    13741 tggctatcag cttgtcgaac aggttgaatt cgtgcagggc aatgaccgca ttgcgccatc
    13801 cggtggcacc gaagtatttg gagaatgaat agacgcaaag cgtattgtag ggaatttctg
    13861 ccatgaacga acggaagtgc ggactgaatg taccgtatac gtcgtctgta ataatcatca
    13921 gattagggtt gtcatttctg acgatgctca cgatgcgcgc cattgtatcc ggactgagtg
    13981 tgtagctggg cggattactg ggattggtga caaagagggc cttgatttta gggcttttca
    14041 agcggtctat gtcttcgtcg ctgtactgcc agaggtgcat cccttcgcta ttcatgcggt
    14101 tggcatgtat tttggtcact cgaaactggt agcggctgag ttgtgggatt tcaatatagg
    14161 gggtaaaggc aggaaccatg aggacgatgc cgtccccttt gttcagcagg aagttttcct
    14221 gcagggagtc gaagatgtag cacatggcgg ctgttccacc ttcggtggca aacaggtcat
    14281 aggcaccccg gggaggacgg ttgtcgcaca tctcttgcga aaggtaatct tgcacaagga
    14341 tttccgtaaa atgaaggatg cggtcgggca cgggatactg atcgcctaca atgctttcgg
    14401 cccattcgtg tacaaggctg tcggggtcgg cggcatgctg catcagcagg tagttgtagg
    14461 tttgttccag caatttggcg cccgatacgt tattgttctt tttcaggaag gcttcgaagt
    14521 gggaggcaat gccttttttt tcggggatgc ctgcaatgcc ctcgggcaaa tccatgatgc
    14581 gacggcactc ttccaagccg aagcttccca ataggaaaaa ggcttcgcgt ggagcggttg
    14641 caa
//
