LOCUS       gnlProkkaIBKANPDH_45   12131 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|IBKANPDH_45.
ACCESSION   gnlProkkaIBKANPDH_45
VERSION     gnlProkkaIBKANPDH_45
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-11-18 05:54:14
            Original ID  :: gnl|Prokka|IBKANPDH_45
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 24587
            Orig. end    :: 36718
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12131
                     /aStool="rule-based-clusters"
                     /category="RiPP"
                     /contig_edge="True"
                     /core_location="[10000:10183]"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..10183
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /neighbourhood="10000"
                     /product="RRE-containing"
                     /protocluster_number="1"
     cand_cluster    1..12131
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="minimum(1,
                     [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE,
                     Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /kind="single"
                     /product="RRE-containing"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12131
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RRE-containing"
                     /region_number="1"
                     /rules="minimum(1, [Bottromycin_Methyltransferase_RRE,
                     Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE,
                     Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE,
                     Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE,
                     Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE,
                     Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE,
                     Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE,
                     Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE,
                     Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE,
                     Thiaglutamate_B_RRE, Thiaglutamate_G_RRE,
                     Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE,
                     Thurincin_rSAM_RRE, Trifolitoxin_RRE])"
                     /tool="antismash"
     CDS             238..1827
                     /gene_functions="regulatory (smcogs) SMCOG1032:RNA
                     polymerase, sigma-24 subunit, ECF subfamily (Score: 65.8;
                     E-value: 6.6e-20)"
                     /gene_kind="regulatory"
                     /locus_tag="ctg45_31"
                     /transl_table=11
                     /translation="MSLLYENYSEKMLKVCLRYIPDPTIAQDLLHDGFVIIFTSIHSLR
                     NPEKLEYWMKKIMRNLALQYLNHANANPTIPLTDIPEEEEPAENPFCPDFISYDKMLDI
                     VESLPEGYCKVFKLAVLEGLSHKEIGDLLGIAPHSSSSQLFRAKILLKKMLAGYRVFIV
                     LTVLLLFPTLYDYLYREKKSIRENRLSKVSSRQAGRTQQTKKTDTPRTDEQCHTKENLN
                     KRERIIPPVPVSTEWPLAIPKMKDSIHKYPIPSPFTGQTITNRQMAFASSPSLMPPTRK
                     KKSRKWKLMLAGSLGPQLAQNLYKLIATPHTDGISSDFPQQVSTWEEYYSYLHTRYQQG
                     TLGKDSIGLMQIAQNNSGRIVENQQHHAPIVVGLSLSKKLNERWSLETGLQYTLLRSEF
                     TTGEAFRIQDNQKLHYIGIPLRLSYRFWHYKRFSSYATAGMQVDIPIKGTLQSFHVTDS
                     IPHKLDSQPVSAPWQWSVNTSIGIQYHLTPQAGIYLEPTVNYYIPDGSQLRTIRKEHPF
                     TFTLPVGLRISW"
     CDS             1909..2706
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 55.3; E-value:
                     1.1e-16)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg45_32"
                     /transl_table=11
                     /translation="MQKRHTDRESYFDEQSQTSKNYYIPYIKEVIGHIPDKVLEVGCGE
                     GGNLLPFAKAGCRVMGVDIDAMRIEQARTFFTQRHQQGQFIATDIFQLKDKATNFPLIL
                     LHDVIEHIRDKERFLSGLQKHLSADGAVFVGFPAWQMPFGGHQQIAHSHIVSHFPFLHL
                     LPRTLYRWILRLCGEQERVITELLDIKSTGCTIELFNRIVRQANYQIIDRRLYLINPHY
                     KIKFGLSPRRLNGVIAAIPYIRNFFCTSCFYILKKGTKTVNHY"
     CDS             complement(2906..3355)
                     /locus_tag="ctg45_33"
                     /transl_table=11
                     /translation="MKERERIGSRLAILRKKRNMTQEELANLCGVNRVNIAKIEKGAYN
                     VSIDILSKVTSALGFVIDIKVDSSVCPTHFSQRKPVKLVIGKDYYVSFGNNEAHRCKLV
                     DIPEMYQGQRIKIETPTPRGSITHILFADEIGTTPDEAVMNQVTM"
     CDS             4672..7644
                     /locus_tag="ctg45_34"
                     /transl_table=11
                     /translation="MEDIFSKRKTLRTIKADTSDYFIPLFHTLAVFLSTKETIITKRFL
                     EHIMKNLIALTLLLGGSTLLCAQKPAKTPATYKPVKSEMYRKGWIDFNKNGVKDVYEDP
                     SAPLEARIENLLQQMTLDEKTCQMVTLYGYKRVLKDDLPTPEWKELLWKDGIGAIDEHL
                     NGFQQWGLPPSDNAYVWPASRHAWALNEVQRFFVEDTRLGIPVDFTNEGIRGVESYRAT
                     NFPTQLGLGHTWNRELIRQVGLITGREARMLGYTNVYAPILDVGRDQRWGRYEEVYGES
                     PYLVAELGIEMVRGLQHNHQVAATGKHFAAYSNNKGAREGMARVDPQMSPREVENIHIY
                     PFKRVIREAGMLGVMSSYNDYDGIPVQGSYYWLTTRLRGEMGFRGYVVSDSDAVEYLYT
                     KHGTAKDMKEAVRQSVEAGLNVRCTFRSPDSFVLPLRELVKEGGLSEEVINDRVRDILR
                     VKFLIGLFDAPYQTDLADADREVEKEENEAIALQASRESIVLLKNAGELLPLDINSTKK
                     IAVCGPNANEEGYALTHYGPLAVEVTTVLEGIQEKTKGKAEVLYTKGCDLVDAHWPESE
                     IIDYPLTDDEQAEIDKAVENARQADVAVVVLGGGQRTCGENKSRTSLDLPGRQLQLLQA
                     IQATGKPVVLILINGRPLSINWADKFVPAILEAWYPGSKGGTALADILFGDYNPGGKLT
                     VTFPKTVGQIPFNFPCKPSSQIDGGKNPGPTGNMSRINGALYPFGYGLSYTTFEYSDLD
                     ITPRVITPNESATVRLKVTNTGKRAGDEVVQLYIRDVLSSITTYEKNLAGFQRIHLEPG
                     EAQELSFTIDRKHLELLDADMKWVVEPGDFVLMAGASSEDIRLNGTLTVEDYQTRAKAI
                     EAQKPAKRVSASTNPEDAENVLDEKINTAWQGNKGDYITFALKNGAKVDKVAIAFTRDN
                     NLPATFEIQLSGGGGQFLTVYSGTVSEYGKLISYPFKGTTASDLRIVLNDDRVSIAEVK
                     F"
     CDS             7746..8873
                     /locus_tag="ctg45_35"
                     /transl_table=11
                     /translation="MKTLLFCMLGLGLTACGSSPKGTNGDQDELAMLIGTYTNGSSKGI
                     YTFRFNQETGTAVPLSSAALPNPSYLVPSEDGEFVYAVSEMNDSTAALSSLAFDRETGE
                     LRLLNTVPTFGADPCYVATNGREVLTANYSGGTMSVFPLQKDGTLAPADTLFQGSATGP
                     DAIRQATPHIHCTVFSPDGKYIFATDFSADRILRFVMHPDDPIPHASLEAVDIEADSGP
                     RHLTFSPNGKFAYLITELSGKVIAFSYDDGCLEQIQTITADTVAARGSADIHLSPDGKY
                     LYASNRLKEDGIAIFAVNPENGTLAKVGYQPTGIHPRNFNITPNGKYLLAACRDSNVIQ
                     VYKRNEVTGLLEDTHQDIVVDMPVCVQFVSSVNNL"
     CDS             9022..9993
                     /locus_tag="ctg45_36"
                     /transl_table=11
                     /translation="MMRGKDYGVTYMLPKTEIEIVLQATKHTYTPGEFCRYADRYLRLN
                     NVSAEPEEFWTLDKIETRIAGVPDKDNVYFVKMKDKTVAPLMELTEDGIVRSINIPFSG
                     KPAAKTPEAKATESSIDPRSFLTEEILMSNSSAKMAELVAKEIYSIRESKNALLRGEAD
                     NMPKDGAQLKLMLDNLNQQETAMTEMFSGKIKKEPKTFTIRLTPKEMKDEVAFRFSRKL
                     GVVANNDLAGEPYYISVTDLKSPDVSATEEGKKKVDGVAYNLPGKAQVTLMYNNKKLFD
                     DQLPITQFGTVEYLAPVLFNKNSTIKVLFDTATGGLIKVDRE"
     CDS             complement(10001..10183)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RRE-containing: PqqD_RRE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF05402"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg45_37"
                     /sec_met_domain="PF05402 (E-value: 4e-17, bitscore: 53.7,
                     seeds: 461, tool: rule-based-clusters)"
                     /sec_met_domain="PqqD_RRE (E-value: 1.7e-09, bitscore:
                     28.7, seeds: 9, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRLEEHGTAVWNLIDGHRTVREIISLLARHFGEEENYIPRVTAYV
                     MQLRKDGFIQLTIRN"
     CDS             complement(10374..11705)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 98.8; E-value: 4.3e-30)"
                     /gene_kind="transport"
                     /locus_tag="ctg45_38"
                     /transl_table=11
                     /translation="MIVAFTMMVAYYVNDVVAPLKTMLETDLAWSSTDFGFFTGGYSFL
                     NVFFLMLIWGGLILDRFGIRFTGKLATILMVGGTALEYYAMTGLAGADATLFGINEIFG
                     YKTGVFVAFAGYSIFGVGAEVAGITVSKIIAKWFKGKELATAMGVQVALARIGSQAGYA
                     VAIPLARAFGISTPVLLGLVLLLGGMIAFFIFAVMDKKLDKQMEAAAIAAGTEDEEEKF
                     SFKDVKNILVNPGFWLIALLCVLFYSCVFPFQKFASELMIIKYGINENVAGTFAGLPAL
                     GALILTPVFGGFIDKRGKSASIMLLGSAMLICVHFIYAIPDINYWLVAIVLMIILGIAF
                     SLVPSAMWPAVAKIFPVSQLGTAYALIFFIQNIGLWGIPTLIGWVLDAYCISGKKPDGT
                     NMYDYTVPMCIFTGIACLSLIVALLLKKADKKYGYKLEEPNIQK"
ORIGIN
        1 caacattccc actccggtgg tgaagctgcc tcaaggattt acgctgaaca gcatcaacta
       61 tgtactgaaa ggcatttgtc cggactgtgc agcagaagtc aaccgggagg cttagttaaa
      121 aaataaaaat ccatgcagtc attcatgttc ttctctatcc ttaagaaata acattgagac
      181 aaacacatgg atacaaaagc tcttgtcact ttatgccaga agggaaacgg gcaggccttg
      241 agcctgctct acgaaaacta ttcagagaaa atgctgaaag tatgcctacg ctatattccc
      301 gacccaacga tagcccaaga tcttcttcac gacggttttg tcatcatatt cacttccatt
      361 cattcgctgc gcaacccgga gaaactggaa tactggatga aaaagattat gagaaacctg
      421 gcactgcaat acctcaacca tgccaatgcc aaccccacca tcccattgac agatattccg
      481 gaagaggaag agcctgctga aaatcctttt tgtccggatt tcatttcgta cgataagatg
      541 ctggatatag tggagagcct tccggagggc tactgcaagg tatttaaact ggcagtactg
      601 gaaggattgt cccacaaaga aatcggagat ttactgggta tagcgccaca ctcctcttcc
      661 tcccaattgt tccgggcgaa aattttactt aaaaagatgc tggcaggata ccgtgtattc
      721 attgttttga cagtattgct tctctttcca acgctatatg actatctgta cagagagaaa
      781 aagagtatca gggaaaaccg tttgtccaaa gtttcttcca ggcaagccgg gaggacgcaa
      841 caaacaaaga aaaccgatac tccccgaacc gacgaacaat gccataccaa agaaaatctg
      901 aacaaaaggg aacgaatcat ccctcccgtt cctgtttcca cagaatggcc ccttgccata
      961 cccaaaatga aagatagcat ccacaaatat cccatacctt ctccattcac cggacagacc
     1021 atcaccaacc ggcagatggc tttcgcctcc tccccttccc taatgccgcc aacccgcaag
     1081 aagaaatcca ggaaatggaa gttgatgctg gcaggttcac tcggaccgca actggcacag
     1141 aacttatata agctgattgc cactccacat accgacggca tttcaagtga cttccctcaa
     1201 caagtcagca cgtgggaaga gtattattct tatctgcaca cccgctatca gcagggtact
     1261 ctgggaaaag attccatcgg actcatgcag attgcccaga ataacagcgg caggattgtt
     1321 gagaaccagc aacatcatgc ccccatcgtc gtgggactct ctctcagcaa gaaattgaat
     1381 gagcgttgga gtctggaaac cggattgcaa tatacgcttc tcaggtcgga gttcactacc
     1441 ggcgaagcat tccgcattca agacaaccag aagttgcatt atatcggcat tcctctccgg
     1501 ctttcctacc gtttctggca ttacaaacgt ttctccagtt atgccacggc aggcatgcag
     1561 gtggatatcc ccataaaagg gacactccaa agcttccatg tcacagacag tattccacac
     1621 aagctcgaca gccagccggt aagtgctccc tggcagtggt cggtcaacac aagtataggc
     1681 atacaatatc acctcacacc ccaggcaggc atctatctgg agccgactgt aaactattat
     1741 atccccgacg gcagccaact gcgcaccatc cgaaaggaac acccgttcac attcaccctc
     1801 ccggtaggcc tccgcatttc ctggtaaaaa aacgatgcgc cacgcagtct tttacccgac
     1861 tgattatcta tttatatgga taatcaaact caagaaggaa caaagaacat gcagaaacga
     1921 cataccgacc gggaaagcta ctttgatgaa cagtcacaga ccagcaagaa ctattatatc
     1981 ccctacataa aggaagtcat cggacacatc cccgataaag tgctggaagt gggctgtgga
     2041 gagggaggca atctgcttcc ctttgccaaa gccggttgcc gggtgatggg cgtagacatt
     2101 gatgccatgc gaatagagca agccaggacc ttcttcaccc aaaggcatca gcagggacag
     2161 ttcattgcca ccgacatttt ccagcttaag gacaaggcta cgaattttcc cctgattctt
     2221 ctacacgatg tgatagagca tatcagagac aaagaacggt tcctctccgg cctacaaaaa
     2281 catttgtctg ccgacggagc tgtatttgta gggtttcccg cctggcaaat gccattcgga
     2341 ggccaccagc agatagcaca cagccacatt gtttcacatt tcccttttct ccacctcctt
     2401 ccccgcactt tatacagatg gatattaaga ctatgcggtg agcaggaacg cgtaatcacg
     2461 gagctactgg atataaagag caccggatgc accatcgaac tgttcaatcg catcgtccgg
     2521 caagccaact atcaaatcat tgaccggaga ctgtacctta taaacccaca ttataaaatc
     2581 aaattcggct tgtccccacg aaggctcaac ggagttattg ctgctatccc gtatataaga
     2641 aacttctttt gtacaagttg cttttacata ttaaagaaag ggactaaaac tgttaatcac
     2701 tactgatttc ccagctttag aattgattcc gaaccatcaa tttaagatta tatattcaga
     2761 agaaaccatt aattttttga atagctctga tgaaagagtg ggtgtagaaa ccctcataaa
     2821 ctaaaaaatc cccctcgctg cagatggttg tagcgaaggt gatttcaata aaagaggaac
     2881 ttgcacttcc tcccttttaa tgtttttaca tcgttacttg gttcattaca gcctcgtcag
     2941 gtgtcgttcc tatttcatcg gcaaataata tgtgggtgat agaccctctc ggggtcggag
     3001 tttcgatttt aattctttga ccttggtaca tctccggaat atcaaccagc ttacatctat
     3061 gggcttcgtt attgccaaaa ctgacataat agtctttccc tattaccagc tttacaggtt
     3121 tacgttgaga gaaatgagtc ggacaaacag agctatccac ttttatatct atcacaaaac
     3181 caagagcgga tgttacctta gatagtatat caatgctcac attataagcc cctttctcta
     3241 tcttggctat attaacacga ttaacaccac aaagattagc caattcctct tgggtcatat
     3301 ttctcttctt gcgaagaatg gctaaccgac taccaatccg ttcacgttct ttcaaaatct
     3361 tctctgtaca ttttccttcg tgaattttca taaatctgtt gcagaattta aagtgttgcc
     3421 cccacttcta atagttattg atttttgaac agacaaaagt agatattaat tttgaattgt
     3481 agcacattta ctacaactat tttctaaatg aatataaaag gtagggggag tagaagaaaa
     3541 gaaaaagccc ctgaattact ggaattcaag gacttacaaa cttcttttta ctatatccgt
     3601 ggagctggag ggaatcgaac cctcgtccaa acgaggaaat cataagcttt ctacatgctt
     3661 atctttgcct aaattttcgt gcagcggcag aaccaaagcc atcaaccgtt gccttatcct
     3721 ctaaattttc acccgcgcca cgaggctgac acgaactatc cccgatttga ctgcaccact
     3781 ttatcggaat gcttcggagc aacagcttcc gagtgatgtc acgtcccagc acctggtgcc
     3841 gggattaagc ttcaatctac tatacttcga ttaagcagcg agagcgtaac gagtttcgcc
     3901 agataaaatt ttgaggactg agattaaagt gcaaatcaac gacgcactgc atgcttactt
     3961 accatttctg cccgctgtca aatccagtca accccatgac tttgtaacgg tctgaaattt
     4021 aaaagattgc gtaactcatt gctaagtagg gagggtgaaa aagggataaa tgctacttta
     4081 tttttcatcc tctaccgctt tctttggccc aaagatacat attcttttat tagcaatcac
     4141 catatattta caaatattag ctaatactga cttttcgtga taaaaacaat aatcttccat
     4201 acatagaata tgtgcacccc attgtcatca atgttcaaac agctaccaaa gccagtatcc
     4261 gttgacggaa ttaccccctg caagagggaa tatctatctt ctgtaatgga tatttgcaca
     4321 aaagagatgg gaaattaacg gaaaaagtct ctgaagttaa ctgaaaaacc ggaaagaatt
     4381 aaggaagcaa tctatcccaa actttggttt tttcataccc agccttggga tgtctaaacc
     4441 aaggtttggt ttagacatcc caaggttgaa aagaaagttc ttccgtacaa gcaacaattc
     4501 cgccaacaga ttcctattat ataaatacac cctcgtttaa cagatgtagc cgtaatactt
     4561 gtatacaccg cgattgcatc tacttttcag gttattatag tgttctctct ttctttttaa
     4621 aagtgaatga tatgtttcgt ctaataatga tttgaattcc ccggtagcgt cttggaggat
     4681 atttttagta agaggaagac ccttcggaca ataaaagccg atacttcgga ctattttatc
     4741 cctttatttc acacattagc cgtatttttg tcaacaaaag aaacaataat aaccaagaga
     4801 tttttagaac atatcatgaa gaaccttatt gccctaaccc tgctgcttgg aggaagcaca
     4861 ctgctctgcg cacaaaagcc tgccaaaaca ccggcaacct acaagccggt gaaaagtgaa
     4921 atgtaccgca aaggttggat agacttcaac aaaaacggag tgaaagacgt gtacgaagac
     4981 ccctccgccc cgctcgaagc acgcatcgaa aacctgctgc aacagatgac gctggacgaa
     5041 aagacctgcc aaatggtcac cctctacggt tacaaacgtg tactgaaaga cgacctcccc
     5101 acccccgaat ggaaagagct gctctggaaa gacggtatcg gcgccatcga cgaacaccta
     5161 aacggcttcc agcaatgggg gctgcctccc tcggacaatg cctacgtctg gcccgcctcg
     5221 cgccacgcct gggcactgaa cgaggtgcaa cggttctttg tggaagatac ccgtctcggt
     5281 atccccgtag actttaccaa cgaaggcata cgcggcgtgg aaagctaccg cgccaccaac
     5341 ttccccaccc aactgggact gggacatacc tggaaccgtg aactgattcg ccaagtagga
     5401 ctcatcaccg gacgcgaagc ccgcatgctg ggctacacca acgtctacgc ccccatcctc
     5461 gacgtaggac gcgaccagcg ctggggacgc tacgaagaag tttacggcga atctccctac
     5521 ctcgtagccg aactgggcat cgaaatggtg cgcggcttgc agcacaacca ccaagtggcc
     5581 gccaccggca agcactttgc cgcttacagt aacaacaaag gcgcccgcga aggcatggca
     5641 cgcgtggacc cgcaaatgtc gccgcgcgaa gtggaaaaca tacacatcta ccccttcaaa
     5701 cgcgtcatcc gggaagctgg catgctgggc gtaatgagtt cgtacaacga ttacgacggc
     5761 atccccgtgc agggcagcta ctactggctc accacccgcc tgcgtggcga aatgggattc
     5821 cgtggctacg tcgtatccga cagtgacgcc gtagaatacc tctacaccaa gcacggcacc
     5881 gccaaagaca tgaaagaagc cgtccgccaa agcgtggaag ccggactgaa cgtacgctgc
     5941 accttccgct cgcccgactc cttcgtcctt cccctccgcg aactggtgaa ggaaggcgga
     6001 ctgagcgaag aagtcatcaa cgaccgcgtg cgcgacatcc ttcgggtaaa gttcctcatc
     6061 ggtctgttcg atgcccccta tcagacagac cttgccgatg ccgaccgtga agtggaaaaa
     6121 gaagagaacg aagccattgc cttgcaggca tcccgcgagt ccatcgttct gctgaagaat
     6181 gccggtgaac tattgccctt agacatcaac tccaccaaga agattgccgt ctgtggtccc
     6241 aatgccaatg aagaaggcta cgcgctgacc cattacggcc cacttgccgt agaagtgacc
     6301 actgtgctgg aaggcattca agaaaagaca aaaggcaagg cagaggtgct ctacaccaaa
     6361 ggctgcgacc tggtggacgc ccactggccc gaaagtgaaa tcatagacta tccgctgacc
     6421 gacgacgaac aagccgagat agacaaagcc gtagaaaatg cccgtcaagc tgatgttgcc
     6481 gtcgtagtat tgggcggcgg acaacgcacc tgcggcgaaa acaaatcgcg caccagcctc
     6541 gacctgcccg gtcggcagtt gcaactgctt caagccatac aagccacggg caagcccgtc
     6601 gtactgatac tcatcaacgg acgcccgctc tccatcaact gggcagacaa gttcgtcccc
     6661 gctatcctcg aagcctggta tcccggctcc aaaggcggaa cagccctggc cgacatcctc
     6721 ttcggcgact acaaccccgg tggaaagctg acggtgacct tccccaagac cgtagggcaa
     6781 atccccttca acttcccctg caaaccttct tcacagatag acggcggtaa gaatccggga
     6841 cctacgggca acatgtcacg catcaacgga gcactctacc ccttcggtta cggcttgagc
     6901 tacaccacct tcgagtactc cgacctcgac atcacccccc gagtcatcac cccgaacgag
     6961 tctgccaccg tccgcctgaa ggtgaccaac accggcaaac gtgccggaga tgaagtagtg
     7021 cagctctata tccgcgacgt actgagcagc atcaccacct acgaaaagaa tcttgcaggc
     7081 ttccagcgca tccacctcga accgggcgaa gcccaggagc tgtccttcac catcgaccgc
     7141 aagcacctgg agcttctgga cgctgacatg aaatgggtgg tggaacccgg cgacttcgtg
     7201 ctcatggccg gcgcctcttc cgaagacatc cgcctgaacg gaacgctgac cgtagaagac
     7261 taccagaccc gtgccaaagc cattgaagcc caaaaaccag caaagcgtgt gagtgccagc
     7321 accaacccag aggatgccga aaacgtgctc gacgaaaaaa tcaataccgc atggcaagga
     7381 aataagggag attatattac ctttgcctta aagaacggag ccaaggtaga taaagttgcc
     7441 attgccttta cacgtgacaa caacctgccg gcaaccttcg aaatccagct ctcgggcggt
     7501 ggcggacagt tcctcaccgt atattcgggc accgtcagcg aatacggcaa actgatttcc
     7561 tatccgttca aaggcactac cgccagcgac ctccgcatcg tgctgaacga tgaccgcgtc
     7621 agtattgccg aagttaaatt ttaatgtgct aatgtgccaa tatgctaatg taccaatgac
     7681 catgcagcat atacagcgca gccaattagc acattagcat attggcacat taacacatta
     7741 aattaatgaa aacacttctt ttctgtatgc tcggattagg tttgacagca tgtggctctt
     7801 ctccaaaggg cactaacggt gaccaggacg aactcgccat gctaataggt acttacacga
     7861 atggctcaag caagggtatc tataccttcc gctttaatca ggagacggga acagccgttc
     7921 cgctcagttc agcggcattg cccaatccct cctacctcgt cccctcggaa gatggcgaat
     7981 ttgtctatgc cgtcagtgaa atgaacgaca gcacagcagc cctcagctcc cttgccttcg
     8041 accgggaaac gggagaactg cgcctgctga acaccgttcc caccttcggc gccgacccct
     8101 gctacgtggc caccaatggc cgggaagtgt tgactgccaa ctacagcggt ggaaccatgt
     8161 ccgtctttcc tttacagaaa gacggcactt tggctcctgc agacacgctc tttcaaggct
     8221 ctgccaccgg tcccgacgcc atacggcaag ccactcccca catccattgc acggtctttt
     8281 caccggacgg aaaatacatc tttgccaccg acttcagtgc cgaccgcatc ctgcgctttg
     8341 tgatgcaccc cgacgaccct attcctcatg cttctctgga agccgttgac attgaagcgg
     8401 attccggccc gcgccatctg acattcagcc ctaacgggaa gtttgcctat ctcatcaccg
     8461 aactgtccgg taaggtcatt gccttcagtt acgacgacgg ctgcctggaa cagatacaga
     8521 ctatcacagc cgacaccgta gccgcccgtg gaagtgcaga catccacctc agtccggatg
     8581 ggaaatacct ctacgccagc aaccgtctga aagaagacgg catcgccatc tttgccgtga
     8641 atcccgaaaa tgggaccttg gcaaaggtag gttatcagcc caccggcatc catccccgca
     8701 acttcaacat cacgcccaac ggcaaatact tgcttgccgc ctgccgcgac agcaatgtca
     8761 ttcaggtata caaacgaaac gaagttaccg gactcttgga agatactcat caggacattg
     8821 tagtcgacat gccggtttgc gtacagttcg tcagctctgt taataattta taaagcaata
     8881 tttagcaaag ataacttcat taactttgtc ccttagctaa atcagtctaa acgaatgtac
     8941 attatgaaga agaatatatt gatgctctca gctctgttct tgtctatcac tgccatggcg
     9001 caaacagacg taaccaccgg tgtgatgcgt ggcaaagact acggagtgac ttatatgttg
     9061 cccaaaacag aaatagaaat cgtattgcaa gccaccaagc atacctacac tcccggagaa
     9121 ttttgcagat atgccgaccg ctatctgcgt ctcaacaacg tgtctgccga acccgaggag
     9181 ttctggacac tggataagat agaaacccgc atagccggtg taccggataa ggacaacgtc
     9241 tatttcgtga agatgaaaga caagaccgta gcacccctta tggagcttac cgaagacgga
     9301 attgtccgct ccatcaacat tccgttcagc ggtaagcctg ctgccaagac gcccgaagcc
     9361 aaagccaccg aaagcagcat tgacccacgc agttttctga cggaagaaat actgatgtcc
     9421 aactccagtg ccaagatggc cgagctggtg gccaaggaaa tatacagcat ccgcgaaagc
     9481 aagaatgccc tcctgcgcgg cgaagcagac aatatgccca aggacggcgc ccaactcaag
     9541 ctgatgcttg acaatctgaa ccagcaggaa acggctatga cggaaatgtt ctcgggcaaa
     9601 ataaagaaag aacccaagac attcaccatc cggctgacgc ctaaagagat gaaagatgag
     9661 gtggctttcc gtttttcccg gaagctggga gtggtggcca ataatgacct tgccggtgaa
     9721 ccgtattata tcagcgtcac cgacctcaaa agtcccgatg tatctgccac cgaggaaggc
     9781 aaaaagaaag tggacggtgt agcctataac cttccgggca aggcacaagt gacattgatg
     9841 tataacaata agaaattgtt tgacgaccaa cttcccatta cccaattcgg caccgtagaa
     9901 tacctcgcac cggtactgtt caacaagaat tctaccatca aagtgctgtt tgatacggca
     9961 acgggaggat tgataaaagt agatagggaa taaaggaatt ctaattccgg attgtcaact
    10021 ggataaatcc atccttacgc aactgcatta cgtaggcggt gacccgggga atataattct
    10081 cttcctcccc aaagtgcctg gcaagtagag agatgatttc gcgcacggta cgatgtccat
    10141 ctatcagatt ccagacagct gtaccgtgtt cttccagcct cacatggatg tcaggagaca
    10201 tccccttcgg caataaaaaa cgacgcatcc attcgtattt aaaccgtggg taggcgagta
    10261 cggcgcactc accttcccat tcggttgtta tatgtccaca gcggaccgga acagcgtcca
    10321 acagacttac ttttccttcg ggtatttcca tcatacggta tccgcttttc ctattatttc
    10381 tgaatattag gctcttccag cttataacca tacttcttgt ctgccttctt cagcagtaga
    10441 gccactataa gggacaagca ggcaataccg gtaaaaatgc acataggcac cgtatagtca
    10501 tacatattcg ttccatctgg tttcttgccg gatatacaat aggcatcaag cacccaccct
    10561 atcaatgtag gaatacccca aagaccgata ttctggataa agaaaatcaa tgcgtatgcc
    10621 gtacccaact ggcttaccgg gaatatcttg gccacagccg gccacatggc agaaggtacc
    10681 agcgagaaag cgatacccaa aattatcatc agcacaatag ctaccagcca atagtttata
    10741 tcgggaatag cataaatgaa atgcacacat atcagcatgg ccgagcccag cagcatgata
    10801 gatgcggact tgccccgctt gtcaatgaaa ccaccaaaga ccggagtcag aatcagcgct
    10861 cccaatgccg gaagtccggc aaatgtaccg gccacattct cattgatacc gtatttgata
    10921 atcatcaact cggaagcaaa cttctggaat gggaatacac aagagtagaa caatacacac
    10981 agcaatgcta tcagccagaa accgggattg accagaatat tcttcacatc cttaaaagag
    11041 aacttctctt cctcatcttc cgtaccggca gcaatggcag cagcttccat ctgtttgtcc
    11101 agcttcttgt ccatcactgc aaagatgaag aaagcaatca taccgcccaa caacagaacc
    11161 aaacccaaca acaccggtgt ggaaataccg aaagcgcggg ccaaaggaat ggctacggca
    11221 taaccggctt gcgaaccgat acgtgctaaa gcgacttgta cccccatagc cgtggcaagc
    11281 tctttcccct taaaccactt ggctatgatt ttggaaactg taataccggc gacctccgct
    11341 cctactccaa aaatggaata accggcaaaa gcaacaaaca cacccgtttt atagccaaat
    11401 atttcattga ttccgaataa agtcgcgtcg gcaccggcaa gtcccgtcat tgcatagtat
    11461 tcaagtgctg taccacctac catcaggata gttgccagct ttccggtgaa acggatacca
    11521 aagcggtcga ggattaatcc tccccaaatc aacatcagga aaaaaacatt cagaaaacta
    11581 taaccaccgg taaagaatcc gaaatcggta ctcgaccaag ccaagtccgt ttccaacatt
    11641 gtcttcaacg gtgctaccac gtcgtttaca taataagcta ccatcatcgt gaaggcaaca
    11701 atcaccaatg ccccccaacg ggtagccttg gaatcattca atttaagttt gagttgttct
    11761 gtcattgtac tatttggatt tcaatttatt aatcagattg cataaattgc tgacaaaggt
    11821 aaataaatac ttcatcaaaa cgaaaaaagg ctgacacctt ttcagtatca acctttctct
    11881 tatttttcca agcgggagtc atccgcaata tccttatctt attctgctgc aggggcttct
    11941 gctgcaggag caggagtttc agccggagtt gtagctgcag gggcctccga ttgcggagct
    12001 tctgtaccta cgggcatgtt ataaggatta gttttttctt cttgttgcgc ctgttccaga
    12061 atcacatcac cgcccttgcc tgtggaagaa ggaatagtgt aagcagaaac aatactgaag
    12121 actaccatga c
//
