LOCUS       c00068_gnlPro..        12031 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|OCIBECHM_68.
ACCESSION   c00068_gnlPro..
VERSION     c00068_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 10:04:33
            Original ID  :: gnl|Prokka|OCIBECHM_68
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12031
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12031
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[1:5003]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      2..5003
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12031
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12031
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             2..871
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_1"
                     /sec_met_domain="ILVD_EDD (E-value: 3.9e-92, bitscore:
                     298.8, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VNRAGGILGIMNELMKAGLVDGSTRRADGLTLAEAVDKYAVTSPN
                     VTEEAIRKYKSAPAHRFSIQMGSQESYYKELDTDRAEGCIRDVEHAYSKDGGLAVLRGN
                     IALDGCVVKTAGVDESIWKFSGPAKVFDSQDAACEGILGGKVVSGDVVVITYEGPKGGP
                     GMQEMLYPTSYIKSRHLGKECALITDGRFSGGTSGLSIGHISPEAASGGAIGLVRDGDI
                     IEINIPERSINVRLSDEELAERRKAEEARGKKAFTPPTRQREVSKALRAYGKMVSSADK
                     GGVRIVED"
     CDS             905..2608
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 6.7e-51, bitscore:
                     161.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LRHVLVRHEQGATHAAQGYARVSGKVGVTLVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRKPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYKKVDYVRSYQPEPDIKKDRIKAAADLINEAKKPFCLVGQGVLLGG
                     AEEELRAFLQKNDIPAGSTVLGLSALPTDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFDRDEKEEYDKVIEKELYPTEGQLKMGEVVRKVSEATGNDAVLVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAMGAKFGAPDRTVCFFTGDGGMQMTIQELG
                     TIMQEKLNVKIIILNNNFLGMVRQWQELFFHERYSNTIMENPDFVAIAKAYGIAGRAVE
                     KREELDDAIAEMLNHDGAYVLVANVETCGMVYPMVPAGGSVTNMIMGDEK"
     CDS             2624..3178
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_3"
                     /sec_met_domain="ALS_ss_C (E-value: 2.6e-17, bitscore:
                     52.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTKKLYTVIIFSENIVGLLNQITIIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDMIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEGLIRKYNARILEMNEACVVLEKSGHYDETQALFNELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLADMERKLHEKQQ"
     CDS             3230..3910
                     /locus_tag="ctg68_4"
                     /transl_table=11
                     /translation="MDFRGRVTLPMIGNYLIHAASSHAGERGFGFNDMSERHTAWVLSR
                     LAIEMKEYPTAFDKINLYTWIDEVGRLFTSRCFELADENGKTFGFARSIWAAIDVETRR
                     PTLLDIEALGKYIDERPCPIEKPGKIMPAENKAEGIPYSIKYSDLDINGHFNSVKYIEH
                     LLDLFDIDQFKTREIGRLEIAYQSEGKQGMPLTLHKAESAPDKQDMAICHEGKAICRAA
                     VTWR"
     CDS             3960..5003
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg68_5"
                     /sec_met_domain="IlvN (E-value: 1.6e-47, bitscore: 150.6,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.1e-40, bitscore: 127.8,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAQMNFGGVVENVMTREEFPLEKAREILKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRQGKTYDKAVEDGWVPGETLFGIEEACDKATIIMCLLSDAAVMS
                     VWPTMKPYLTAGKALYFSHGFAITWNDRTGVVPPADIDVIMVAPKGSGTSLRSMFLEGR
                     GLNSSFAIYQDATGKAMDRTLALGIGIGSGYLFETTFIREATSDLTGERGSLMGAIQGL
                     LLAQYEVLRENGHTPSEAFNETVEELTQSLMPLFAKNGMDWMYANCSTTAQRGALDWMG
                     PFHDAIKPVVEKLYANVKCGNEAQISIDSNSKPDYREKLEAELKALRESEMWQTAVTVR
                     KLRPENN"
     CDS             complement(5073..5414)
                     /locus_tag="ctg68_6"
                     /transl_table=11
                     /translation="MEARPTQKQVITSSLFWESYDNVYVQGLDLFGFYQAELYANKIKS
                     ILYELDQTYPYYPECRHLATKSRMYRNIILDSHLIIYRITEERIEVLDIVHSASSMRKI
                     KKTRNIHIE"
     CDS             complement(5381..5617)
                     /locus_tag="ctg68_7"
                     /transl_table=11
                     /translation="MTKLSNIPAKETTAKTAKTRKTKTGPAKLKWDPTKPVQFTQEEIW
                     EHIHEIEKGPFLTLDEGFKRFEAWKQDLLKSRL"
     CDS             5840..6070
                     /locus_tag="ctg68_8"
                     /transl_table=11
                     /translation="MNFGVWGVQVFITYFFISYIYYVLYIKRVYENHMMMCDRYIMLTF
                     FISMRLVNRNNCVASKQASKQASKQASKQAS"
     CDS             6284..10789
                     /locus_tag="ctg68_9"
                     /transl_table=11
                     /translation="MRLSLIAMVLCLCAAWPGHGLAWGMTGSASPAGMTPGAPQSQAKG
                     EVRFSNTLDPVAYSFIYKWDPMATWSLNFNIENFTKGMAVRVQLANTANPDGVEFRFED
                     SEPAQTLDNGGFWIPDEKLTDYGYSVGLRLQMNSSKECSADYTVKVYSSRDMGTAALAS
                     TGQTIRFMLGDKAPAMGELSRTSGDLNEDIPFAINVTKAGFLQGQHAKMKIYLNGPSEG
                     LTLSGQNLSKETGLYNEPIYVLDIPSFSATQFTLMAHATEEWNGTVQVDICDADDNRIV
                     YGGQAPFVFPANNSQDDIAALKAIAEANPLNSDLQNFISNKDYLKDRGSNDGYNVGVTW
                     NTESTSRVKSFFIDDGRTQTVTTMDVSALSGLEQLDLQNTRLKSLDLSTLTKLRSLSLY
                     GNDSLTWFTVKLPNSLPENFWMNGYTTIMAGTPVDGNNAYAAAGTEIDLSAYATVGGVK
                     SVYQWYLIDRATGKRTKATMQAVSGKDGAFIFEGKPGEYYKCEITNNNYRDWCMETPRI
                     KVARGSADYSPADIAGLKKLAADNPNITQLKEFVDSKGWERENWNSYQDNIRTDWSTGE
                     VGRLTHLYIWFEWNSTDTISQLDLSAFTELRHFECENHMNISKLDVSKNTKLEHLHIYS
                     KNLSSIDLSKCPELRYFRFGTNRTLEGRYQDTKLAALNLTGCSKLTELYLEHSPLASLD
                     ISSFKLLSRLEIEYCPNLKLQGFDKVTSLTYLALPHTEQFADLVKNLPASIRQLYLQDT
                     EYELPSSQVGKNLESLGLPGYVESLDLAQYPNLSNLNADGSLLRYSTVKNYRQINYEGW
                     GRITLTSPSHPGDPYWFENGDTIDLSSEAVIDGIETVFLWVNAKYRTEEKEALKPVPNR
                     PGVFVLNSKEEKYGDYYCKLMNPRFCEITEINVRSGWQIETSRIHVETTVPQVFAESDV
                     ATLARIVDASNNKALSEWWSSDAWKTNEGSLYAQAVWNDENPRRLIHLYMYEMGESFTK
                     KVDLAALDKLEILSLTGNRVEELTLPKNNTVLRSLMLGGNYSLKSLIVSEYPSLEYLDV
                     SSTDLTALDLSKNKNLKELFLNWTMLDGVENSASASGLAAQLTAYGLPIPTTRIDLADF
                     PALMSFNADGSCLEFANVENPRQLEAAFGVVRLPVGEVRPGGFVAYGETIDLSSQKMVG
                     TSASRFTWVFDGDTIDHTDSRYTITEDLTPNYQIAGLVTNPLFPGWTVQYDAWVYTCDG
                     DANLDMLVNVQDVTATVSYILRDKDNMIPNFGFAEADVNYNNNVEIADVIGIVNLIHGK
                     PVTKASALRSEAEVPVQMELDADNFLTMNSQVPVAGIYLELVGAIDEIPLLGDAAKFLQ
                     ASSLNGDTLRVIGYSLDGRTIPSGKSRILRMPAGVTLVGASFSDAKANSLRSGGDAIVT
                     SNAPIEAISRLEAVSNYPNPFRGSTTFSYQLEEPAQTVMIHVFSASGALTAVLNGLPGE
                     VGENRYTVALPLPAGVYYYRLTAKTGHGVKASNTNIFICK"
     CDS             10793..12031
                     /locus_tag="ctg68_10"
                     /transl_table=11
                     /translation="MKVNHIKQLFVALFLLLSAGTATAAQWKLAKTNLNAAGSKDTLTL
                     KVSDNTVDFSSFQVDFTLPAGVLLSGTPILGELADDHALTWSKRADGSFRCVVYSVRNT
                     EMKAPGAVLRIPVELAVSFVEGTFTAKNGLLSDKASKGQPVTDLTATLTSHKEKAKLVV
                     NVSGLEQVVNTEKAAVLDCKTIPATLPDGKTLTIGYYKDEKCTEVAGESDRKQEGIFFV
                     KVSYPEDAEYEAFEQIYTMSLTSKKAIAEGDITPPTAASIKAGQSLSTSLLSGGSVTDE
                     GYLVAGTFAWTYGNTVVPAGTHEYSVTFYPDNSSYYNTAALSVAVKVDTTYKVTAVQTT
                     GGAVNVLGKAEDNVYVKGQKISLVATPLPNYQLSSWSIAGESVDLGKKDTLTVTVGADR
                     TYSANFTPILHKVS"
ORIGIN
        1 cgtaaaccgt gccggtggaa tcctcggtat catgaacgag ttgatgaaag ccgggcttgt
       61 ggatggcagc acgagacgtg cggacggcct gaccttggcc gaggctgttg ataaatacgc
      121 cgtcacttcc ccgaacgtaa cggaggaggc gatccgtaaa tacaagagcg ctcccgctca
      181 tcggttcagt atccagatgg gttcccaaga atcttattat aaggaattag atacggatcg
      241 tgccgaaggt tgtatccgtg acgtggagca cgcttattcc aaggatggcg gcttggctgt
      301 tttgagaggg aatatcgcct tggacggatg tgtcgtaaaa accgccggcg tggatgagag
      361 tatttggaaa ttctccggcc cggcgaaagt cttcgattca caggatgccg cttgcgaggg
      421 cattttagga ggcaaggtcg tttcaggcga tgtggtcgtc atcacgtatg agggtccgaa
      481 aggagggccg ggaatgcaag agatgttata tcctacctct tatataaaga gccgtcactt
      541 aggtaaggag tgcgccttga tcacggatgg tcgtttcagt ggcggtacgt ccggtctttc
      601 tatcgggcat atctctcctg aggccgcttc cggtggcgct atcggactgg tgagagacgg
      661 ggatatcatc gagatcaata tcccggaacg ttccatcaac gtgcggctga gcgacgagga
      721 gttggccgag cgccgtaaag cggaagaggc gcgtggaaag aaagccttta cgccgccgac
      781 gcgtcagcgt gaggtctcga aagcgttgag agcgtacggg aagatggtta gctccgccga
      841 taagggaggt gtaaggattg ttgaagatta aagccaataa tatacattaa acacgttatt
      901 tcttatggag aaacaaaaga taaccggttc ggaagctttg ctgaaagcgt tgattgctga
      961 aggagtagat actatcttcg gttatcccgg cggacaggcg atacctattt acgacagttt
     1021 atatgattat agggaccagt tgaggcatgt attggtgcgc cacgagcaag gcgctaccca
     1081 tgcggctcaa ggatatgccc gtgtatccgg caaggtagga gtgacgttgg ttacttccgg
     1141 cccgggcgct acgaatacca tcacgggtat cgctgatgcg ctgatggata gtacgccaat
     1201 ggtcgtaatc gccggtcaag taccctcgcc gttgttggga accgatgctt ttcaggaagt
     1261 cgacgtgatt ggcatcacgc aaccgatcac gaaatgggct tatcaaatcc gcaagccgga
     1321 ggagatcgca tgggctgttt ctcgtgcttt ttatatcgct tctacaggcc gtccgggtcc
     1381 agttgtgctg gatttagcga aggacgcgca agtagggctg gtggactatg aatataagaa
     1441 ggtagattac gtacgtagtt atcagccgga gccggatatc aaaaaggatc gtatcaaggc
     1501 cgccgccgat ttaatcaatg aggcgaagaa acccttctgt ctggtcgggc agggagtatt
     1561 gttaggcggt gcggaagagg aattgagagc gtttctccaa aagaatgata tacctgccgg
     1621 atctacggta ttgggcttat ctgcgttgcc aaccgatttc ccattgaaca agggaatgct
     1681 cggtatgcat ggaaacgtag ggccgaaccg gaaaacgaat gagtgtgatg tattgatcgc
     1741 tatcggtatg cgtttcgacg accgtgtgac tggcgattta aagacatacg ctaagcaagc
     1801 caagattatc catctggata tcgacaactc ggaaatcggt aagaacgtcc ccgtagatgt
     1861 aaaggtgctg ggtaatgcca agcacacgat accgatgatc acggcgttgt tggaagaacg
     1921 taaacgtccg gaatggaatg ccgagttcga tcgggacgag aaagaggaat acgataaggt
     1981 aatcgagaag gaattgtatc cgaccgaggg ccaactgaaa atgggcgagg tagtccgtaa
     2041 ggtttccgag gcgaccggta acgacgctgt attggtgacc gacgttgggc agaaccagat
     2101 gatgggtgtc cgctatttca aatataaaca aacccgtagc gtggtgactt ccggaggttt
     2161 aggtacgatg ggatttggtc tgccggccgc tatgggcgct aagttcgggg ctccggaccg
     2221 tacggtctgc ttctttaccg gtgatggggg tatgcagatg acgattcagg aattgggtac
     2281 catcatgcag gagaaactga acgtgaagat tatcattctt aataataact tcttaggtat
     2341 ggtacgtcag tggcaagaat tgttcttcca cgagcgttat tcaaacacca tcatggagaa
     2401 tccggatttc gtggcgatcg ctaaagccta tggtatcgct ggccgtgccg ttgaaaagcg
     2461 ggaggaattg gacgacgcta tcgccgagat gctaaaccac gacggcgctt acgtgttggt
     2521 cgctaacgtg gagacttgcg gaatggtata tccgatggtt cctgccgggg gaagcgtgac
     2581 aaacatgatt atgggagacg agaaataagg aggagatgaa gctatgacaa caaagaaatt
     2641 atataccgtt attatctttt cagagaatat cgtaggtctt ttgaaccaga taacgattat
     2701 ctttacacgc cgacagctga acatcgagac tctgtccgtc tctccgtccg ctatcaaggg
     2761 catccataag tttacgatca cgaccttcgc cgatgaggat atgatcgata aggtggtgaa
     2821 acagatcgat aaacgtgtgg atatcttgaa ggcttattat aatacggatg aggatctggt
     2881 ttatcaagag atcgcccttt ataagctaag taccgagctt ttcatcaaga tgggaaccgt
     2941 ggagggattg atccgtaaat acaacgctcg tatcttggag atgaacgagg cctgcgtggt
     3001 gttggagaag agtggccact atgacgagac acaagccttg ttcaatgagt tgagcgagac
     3061 gatcggtgtc ctgcaattca tccgctccgg acgtgtggct atcacgaaga gcaaggtgga
     3121 gcgcttgagc gatatgttgg ccgatatgga gcgaaagtta catgaaaagc aacaataata
     3181 agatatggag aaagtaggat tatttcattt cgtggcggag ccgtatttga tggatttcag
     3241 gggacgtgta acgctcccta tgattggtaa ctatttgatt cacgccgctt ccagccatgc
     3301 cggagagcgt gggttcggtt tcaatgatat gtcggagcgt catacggctt gggtgttgtc
     3361 ccgtctggct atcgagatga aggaatatcc taccgccttc gataagatta atctatacac
     3421 ttggatcgat gaggtcggac gcctcttcac cagtcgttgt ttcgagctgg cggatgagaa
     3481 tgggaaaacc tttggattcg cccgttctat ttgggcggct atcgacgtgg agacccgccg
     3541 tcctacctta ttggatatag aggcattggg caaatatatc gacgagcgtc cgtgcccgat
     3601 cgagaagccg ggcaagatca tgccggcgga gaataaggcg gagggaatcc cgtattcgat
     3661 caaatacagc gacttggata tcaacggtca cttcaatagc gtgaagtata tcgagcacct
     3721 gctggatttg ttcgatatcg atcagttcaa gacccgtgag atcggccgtc tggagatcgc
     3781 ctaccaatcc gagggtaaac aaggtatgcc gcttacgctt cataaggcgg agtccgctcc
     3841 cgataagcaa gacatggcta tttgccatga gggaaaggcg atctgtcgtg cggcggttac
     3901 ttggagataa taaaagagat acataaatag gtttttaaac attaatagtt aaaaagaaaa
     3961 tggcacaaat gaattttggc ggtgttgtag agaatgtaat gacccgcgag gaatttccgt
     4021 tggaaaaggc aagagagata ttaaaagatg agacaatcgc tgttatcggc tatggcgtac
     4081 agggaccggg acagtcattg aaccttcgtg acaatggctt caacgtaatc gttggccagc
     4141 gccaaggtaa gacttacgat aaagcggttg aggacggatg ggttccgggt gagactctgt
     4201 tcggtatcga ggaggcttgc gacaaggcca cgatcatcat gtgcttgttg tccgacgctg
     4261 ccgtaatgtc tgtatggcct acgatgaagc cttatttgac agctggcaag gccctgtatt
     4321 tctctcatgg ttttgcgatc acttggaacg atcgtacggg cgttgttcct cccgcggata
     4381 ttgacgtgat catggtcgct ccgaaggggt ctggtacgtc tttgcgttcc atgttccttg
     4441 agggtcgtgg cttgaactct tctttcgcta tctatcaaga cgctactggc aaggcgatgg
     4501 atcgtacgtt ggcgttgggt atcggtatcg gttccggcta cttgttcgag acgactttca
     4561 tccgtgaggc tacttccgat ttgactggtg agcgtggttc cttgatgggc gctatccaag
     4621 gtttgttgtt ggcccagtat gaggtattgc gcgagaatgg acatactcct tccgaggctt
     4681 tcaacgagac ggtcgaggag ttgactcaat ccttgatgcc tttattcgcc aagaatggta
     4741 tggactggat gtacgcgaac tgctctacta ccgcccagcg tggcgctttg gactggatgg
     4801 gtccgttcca cgacgcaatc aagccggttg tcgagaaatt gtacgcaaac gtaaaatgcg
     4861 gtaacgaggc tcagatctct atcgactcaa actctaagcc ggattatcgt gagaaattgg
     4921 aggctgaatt gaaggcattg cgcgagagcg agatgtggca gacagctgtt actgtacgta
     4981 agcttcgtcc ggagaacaac taatccaatc ttaatcctta tatatcagca aaaagaggcg
     5041 ggtcacttac gggtggctcg cctttctttg tgttattcga tgtggatatt cctagtcttc
     5101 ttgatctttc gcatgctgga tgctgaatgg acgatgtcca gcacctcgat gcgttcctcg
     5161 gtgatgcggt agatgataag gtgtgaatct aggatgatgt tccggtacat gcggcttttc
     5221 gtggctaggt gtcggcattc gggataataa ggataggttt ggtctaactc gtataagatg
     5281 gattttatct tgttagcgta taattccgct tggtagaatc caaataagtc aaggccttga
     5341 acatatacat tatcgtaact ttcccaaaat aaactactgg ttataacctg cttttgagta
     5401 ggtcttgctt ccatgcctca aaacgtttaa aaccttcatc tagggttagg aacggtccct
     5461 tctcaatctc atggatatgt tcccagatct cttcttgggt gaattgcacc ggcttggtgg
     5521 gatcccactt gagctttgcg ggtccggtct tggtcttacg tgtctttgcg gtcttggccg
     5581 tagtttcctt ggcggggatg ttgcttaatt ttgtcatagt cgtaatcgtt attaattagt
     5641 actgtggcaa atgtatggaa taatttccat gtaataagat atttggtaag gaaaaaagta
     5701 ggtctatagg attaactcat tacccagttg tagagacggg gcgtgccccg tctccatccc
     5761 ctcaaaatgg tattcaaatt tatttatgtc acataaccgc tatttttaat cgcttatctg
     5821 ctatatacgc acaataagca tgaattttgg ggtgtggggt gtgcaggtct ttattacata
     5881 tttttttatt tcttatattt actacgtctt atacattaaa agagtatatg aaaatcatat
     5941 gatgatgtgt gatagatata taatgttaac cttttttatc agtatgcgtt tggtgaatcg
     6001 gaataattgt gtagcaagca agcaagcaag caagcaagca agcaagcaag caagcaagca
     6061 agcaagctaa cccagatcta ttatatgtat acgccgggcc ggtatgcgga ggatttcctc
     6121 cgcataccgg cccggcgtgt ttgcgcttgg cgcatggaga aaaggtcatc ctacgaatga
     6181 cacgctaaat cgggaatggt gagagatacc gatacgtatt atgaatacaa aacacctatt
     6241 tataaattta ttgcttatga aaacaatttt gcgaggaatt agtatgaggt tgtcgctcat
     6301 cgcgatggtc ttatgtttat gcgccgcatg gccggggcat gggctggctt ggggtatgac
     6361 cgggtcggcg agcccggcgg gaatgacacc cggggctcca cagagccagg cgaaagggga
     6421 ggtacggttt tccaatactc tggatcctgt agcttatagc tttatctaca agtgggatcc
     6481 gatggctact tggagcttga atttcaatat cgagaacttc acgaagggca tggctgtacg
     6541 tgtacagctg gcgaacacgg cgaatccgga cggggtagag ttccgctttg aggattctga
     6601 gccggcgcaa acgttagaca atggcggctt ttggataccg gacgagaagt tgacggacta
     6661 tggatatagc gttgggcttc gtctgcaaat gaatagctcg aaggagtgtt cggcggacta
     6721 taccgtaaaa gtgtacagct cgcgagacat gggcacggct gccctagcct ctaccgggca
     6781 aacgatacga tttatgctcg gtgataaggc tcccgctatg ggagagttgt cgcgtacatc
     6841 cggcgatctg aacgaggata tcccttttgc gatcaacgtg acgaaggctg gtttcctgca
     6901 ggggcaacac gctaagatga agatttatct gaatggccct tctgaaggct tgaccctttc
     6961 cgggcagaac ctaagtaaag agactggtct atataatgag cctatatacg tattagatat
     7021 tccttcgttc tccgctacgc aattcacgtt gatggctcac gccacggagg aatggaacgg
     7081 aacggttcaa gtggatattt gtgatgcgga cgacaatagg atagtatatg gcggccaagc
     7141 accgttcgtt tttccggcca ataactcaca ggacgatata gccgctttga aagcgatcgc
     7201 cgaggccaat ccgctgaact cggacttgca gaacttcatc tccaacaagg attacttgaa
     7261 agacagggga tcgaacgatg gctacaacgt gggcgtgaca tggaacaccg agtccacgag
     7321 ccgggtgaaa agcttcttca tcgatgatgg taggacacag acggtcacta ccatggatgt
     7381 atcggcgttg tccgggttag agcagttgga cttgcagaat acccggttga aatccttgga
     7441 tttgtccact ttgacaaaac ttcggagctt gagtttgtat ggtaatgatt cgcttacttg
     7501 gtttacggtg aagctcccga actcgttacc ggagaatttc tggatgaatg gttatactac
     7561 gatcatggcc ggtactccgg tagatggcaa taacgcttac gccgcagcag gcacggagat
     7621 cgatctatcc gcttacgcta cggtgggtgg cgtgaaatcg gtatatcaat ggtaccttat
     7681 tgatcgggct actggtaaac ggacgaaagc gactatgcag gcggtatctg gcaaggacgg
     7741 tgctttcata tttgaaggaa agccgggcga atattataag tgcgagatca caaacaataa
     7801 ttacagagat tggtgtatgg agacaccaag gatcaaggtt gctcgtggct ctgcagacta
     7861 ctcccctgcg gacatcgccg gattgaagaa gttggctgcc gataacccga atatcaccca
     7921 attgaaggag ttcgtggata gcaagggctg ggagcgcgag aattggaact cttatcaaga
     7981 caatatccgc acggactgga gcacgggtga ggtaggccgg ttgacacatt tatatatctg
     8041 gttcgagtgg aactctacgg atacgatctc tcaattagac ctaagcgctt tcaccgagtt
     8101 gaggcatttc gagtgcgaga atcacatgaa tatctcgaaa ctggatgtat cgaagaacac
     8161 gaagctggag cacttgcata tatatagtaa gaatctgtct tctattgacc tatccaaatg
     8221 tccggaactg cgatatttta gattcggtac gaatcgcacg ttggagggac ggtaccaaga
     8281 tacgaagctg gcggcactga accttaccgg ttgttcgaag ctgacggagc tttaccttga
     8341 gcattcgcct ttggcttcgc tggatatctc atccttcaag ctattgagcc gtctggagat
     8401 tgagtactgc ccgaacttga agttgcaagg tttcgacaag gttacgagct tgacctattt
     8461 ggccttgccg catacagaac agttcgcgga tctggtaaag aacctgccgg catctatccg
     8521 tcagctatat ctgcaagata cggagtatga gcttccttcc tcacaagtag ggaagaattt
     8581 ggagtcgttg ggattgccgg gatacgtgga gagtctcgat ctggctcagt acccgaactt
     8641 gagtaacttg aatgcggatg gatctctttt gagatattct acggtgaaga actaccggca
     8701 gataaattat gagggttggg gacgcataac gcttacttcc ccctctcatc cgggagatcc
     8761 atactggttc gagaacggcg atacgatcga tctctcctcg gaggccgtga tcgatggcat
     8821 agagaccgta ttcctatggg taaacgccaa atataggaca gaggagaaag aggcattgaa
     8881 gccggtgcca aaccgtccgg gcgtatttgt gctgaacagc aaggaggaaa agtatggaga
     8941 ctactattgt aagctgatga acccgaggtt ctgtgaaatc acggagatca atgtacgttc
     9001 cggttggcag atcgagacct cacgtatcca tgtggagacc accgtccccc aagtattcgc
     9061 cgagagcgac gtggctacct tggcacgtat cgtagacgct tccaacaaca aggcattgag
     9121 cgagtggtgg agcagcgacg catggaagac aaacgagggc tcactgtatg cgcaagccgt
     9181 ttggaacgac gagaacccgc gccgcttgat acatttatat atgtatgaga tgggcgaaag
     9241 ctttacgaag aaggtagatc tcgctgcctt ggataagctg gagatcttgt cgttgacagg
     9301 caatagggtg gaggaactga ccttgccgaa gaacaatacg gtattgcgtt ctttgatgct
     9361 gggtggaaac tattctttga aatctttgat cgtatccgag tatccatcgc tggagtatct
     9421 ggatgtgtct agtacggact tgacggctct cgacttgtct aagaacaaaa acttgaagga
     9481 gttgttcttg aattggacga tgcttgacgg ggtagagaac agcgcttcgg cttcgggcct
     9541 tgccgctcaa ttaaccgcat atggcttgcc tatacccact acccggatcg atttggcgga
     9601 cttcccggcc ttgatgtctt tcaatgccga tggttcgtgc ttggagttcg ctaacgtgga
     9661 gaacccgcgg caattggagg ctgccttcgg tgttgttagg ttgccggtag gtgaggttcg
     9721 tccgggaggt ttcgtggctt atggggagac aatcgatctt tcctcacaaa agatggtagg
     9781 tacatccgcc tctcgcttta cttgggtatt cgacggcgat acgatcgacc atacggacag
     9841 ccgctatacg attaccgaag acttgacccc gaattatcaa attgctggtc ttgtaaccaa
     9901 tccattattc cccggctgga cggttcagta cgatgcgtgg gtttacacct gcgatggcga
     9961 tgcgaacctc gacatgctgg taaacgtaca agacgtgacc gctaccgtaa gctacatctt
    10021 gcgggacaag gataacatga tccccaactt cggttttgcc gaggcggatg tgaactataa
    10081 taataatgta gagatcgctg acgtaatcgg tatcgtcaac ctcatccacg gcaagccggt
    10141 taccaaggcc agtgcactgc gttctgaggc cgaggttccc gtacaaatgg agctcgacgc
    10201 tgataacttc ttgacgatga atagccaagt accggtagcc ggtatctatc tggagttggt
    10261 gggagccatc gacgagatcc cgttgctggg cgatgccgcc aagttcctgc aggcttccag
    10321 cttgaacggg gataccttgc gggtgatcgg ttatagcttg gatggccgca cgattccttc
    10381 gggcaagagc cgtatcctgc gtatgccggc gggcgttacc ttggtaggag cctccttctc
    10441 cgacgcgaag gccaacagct tgaggtccgg tggcgacgcg atcgtaacct ccaatgcccc
    10501 gatcgaggcg atcagccgct tggaggccgt ctccaactat ccgaacccgt tccgtggcag
    10561 cacgaccttc tcttatcaac tggaggaacc cgcccagacg gttatgatcc atgtattctc
    10621 cgcgagcggt gcgttgaccg cggtactgaa cggtttgccc ggcgaggtag gcgagaaccg
    10681 ctatacggtt gcccttcctt taccggcggg cgtttactac taccgcttga cggcgaagac
    10741 aggccatggt gtgaaggcaa gtaatactaa catctttatc tgtaagtaaa ttatgaaagt
    10801 gaatcatata aaacaattat tcgtagccct cttcctgctg ttatcggcgg gaacggctac
    10861 cgccgcccag tggaaattgg cgaagacgaa cctgaacgcc gctggcagca aggatacgct
    10921 caccttgaag gtatccgata atacggtaga tttctcctca ttccaagtgg atttcacctt
    10981 gccggcgggc gtattgctga gcggtacgcc tatcctcggc gagctggcgg acgatcatgc
    11041 gctcacgtgg agcaagcgcg ccgatggcag cttccgctgc gtggtataca gcgtgaggaa
    11101 taccgagatg aaggccccgg gtgccgtgct acgcattccg gtagagctgg cggtctcttt
    11161 cgtggaaggg acgttcacgg cgaagaacgg tctcttgtcc gacaaggcat ccaagggaca
    11221 gccagtcacg gatctcaccg ctaccttgac ctctcataag gaaaaggcca aactggtcgt
    11281 gaacgtatcg ggcttggaac aggtggtcaa tacggagaaa gccgctgtat tggactgtaa
    11341 gaccatcccg gcgacccttc ctgatggcaa gaccttgacg atcgggtact ataaggacga
    11401 gaaatgcaca gaagtcgcag gcgaatcaga ccggaagcaa gaaggcatct tctttgtcaa
    11461 ggtatcctat ccggaagacg ctgaatacga ggctttcgag caaatctata ccatgagcct
    11521 gacaagcaag aaggctatcg ccgagggcga catcactccc ccgactgccg caagcatcaa
    11581 ggcgggccaa tcgctttcaa cctccttgct gtccggcggt agcgttacag atgagggata
    11641 tctggtagcc ggtaccttcg cttggacata cggaaacacc gtggtgccgg caggtacgca
    11701 tgagtactcc gtgacgttct atccggataa ctcttcttat tacaatacgg cggcgttgtc
    11761 cgtggcggtc aaggtagaca cgacctataa ggtcaccgct gtacagacaa cgggtggtgc
    11821 cgtaaacgta ttaggcaagg ctgaggataa cgtgtatgta aagggtcaaa agatctcctt
    11881 ggtagcgacc cctctaccca actatcagct ttcaagctgg tcgatcgcgg gcgagagcgt
    11941 agacttgggc aagaaagaca cgctcacggt tacggtaggt gcggatcgaa cctatagcgc
    12001 caactttacc ccgatcctgc ataaggtatc t
//
