LOCUS       c00131_gnlPro..        12892 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|BGPLEOGN_131.
ACCESSION   c00131_gnlPro..
VERSION     c00131_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 10:17:28
            Original ID  :: gnl|Prokka|BGPLEOGN_131
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12892
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12892
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[144:6130]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      145..6130
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..12892
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..12892
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             145..1980
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg131_1"
                     /sec_met_domain="ILVD_EDD (E-value: 2.1e-218, bitscore:
                     715.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MMKNPLRSSYSTEGRRMAGARALWRANGMKEEQFGKPIIAIVNSF
                     TQFVPGHVHLHEIGQQVKAEIEKLGCFAAEFNTIAIDDGIAMGHDGMLYSLPSRDIIAD
                     SVEYMVNAHKADAMVCISNCDKITPGMLMASMRLNIPTIFVSGGPMEAGNLDGRALDLI
                     DAMIEAADDSISDEQVEKVERSACPTCGCCSGMFTANSMNCLNEAIGLALPGNGTVVAT
                     HANRTRLFKKAAKMIVDNAFKYYRDGDDSVLPRSIATRQAFLNAMSLDIAMGGSTNTVL
                     HLLAVAHEAEVDFTMKDIDMLSRKTPVICKVAPSCSYHVEDVNRAGGIIGIMNELVKAG
                     LVDGSVKRADGLTLNEAIDQYCITSVNVTEEAINIYKSAPAHRFNLVLGSQESYYKELD
                     TDRATGCIRDVEHAYVKDGGLAVLYGNIAQDGCVVKTAGVDESIFRFAGPAKVFDSQDA
                     ACEGILKDQVVSGDVVVITYEGPKGGPGMQEMLYPTSYIKSKHLGKECALITDGRFSGG
                     TSGLSIGHISPEAAAGGAIGLVKDGDIIEINIPERTIHVKVTDEELAKRREAEEARGTK
                     AFTPPFRQRTVSKALKAYAKMVASADKGGVRIVED"
     CDS             2007..3707
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg131_2"
                     /sec_met_domain="TPP_enzyme_C (E-value: 2.7e-51, bitscore:
                     162.5, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDKQKITGSEALLKALIAEGVDTIFGYPGGQAIPIYDSLYDYRDQ
                     LKHILVRHEQGATHAAQGYARVSGKVGVTVVTSGPGATNTITGIADALMDSTPMVVIAG
                     QVPSPLLGTDAFQEVDVIGITQPITKWAYQIRRPEEIAWAVSRAFYIASTGRPGPVVLD
                     LAKDAQVGLVDYEYQKVDYVRSYQPEPDIREERIEAAASLINNAKKPFCLVGQGVILGG
                     AEEELKEFLLKNDIPAGSTVLGLSALPSDFPLNKGMLGMHGNVGPNRKTNECDVLIAIG
                     MRFDDRVTGDLKTYAKQAKIIHLDIDNSEIGKNVPVDVKVLGNAKHTIPMITALLEERK
                     RPEWNAEFEPDEKEEYNKVIEKELYPTEGQLKMGEVVRKVSEATDNDAILVTDVGQNQM
                     MGVRYFKYKQTRSVVTSGGLGTMGFGLPAAIGAKLGAPDRTVCFFTGDGGIQMTIQELG
                     TIMQENLNVKIIVLNNNFLGMVRQWQELFFNERYSNTIMKNPDFVAIAKAFGIASRAVD
                     KREDLDEAIAEMLNHDGAYMLVANVETCGMVYPMVPAGGSVTNMILGDK"
     CDS             3720..4274
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg131_3"
                     /sec_met_domain="ALS_ss_C (E-value: 9e-19, bitscore: 56.7,
                     seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNTKQLYTVIIFSENTVGLLNQITVIFTRRQLNIETLSVSPSAIK
                     GIHKFTITTFADEDTIDKVVKQIDKRVDILKAYYNTDEDLVYQEIALYKLSTELFIKMG
                     TVEDLIRKYNARILEMNEDCVVLEKSGHYDETQALFKELSETIGVLQFIRSGRVAITKS
                     KVERLSDMLSAMEKKLQEKHV"
     CDS             4311..5042
                     /locus_tag="ctg131_4"
                     /transl_table=11
                     /translation="MEKNKVGEFHFVTESYLTDFRGRITIPMIGTYLLHAASCHAADRG
                     FGYNDMTERHTAWVLSRLAIEMTSYPAMSESVTLYTWVDEVGKLFTSRCFELVNGEGKT
                     FGFARSIWAAIDMETRRPTLLDVEGLSAYITDRPCPIEKPGKIAPVENNTSGEPYRVKY
                     SDLDVNGHLNSIKYMEHLLDLFDISLFREKEISRFEIAYQSEGKYGMELTLHNQEVSLD
                     KYNMAICNDGKAISRAAVTWI"
     CDS             5084..6130
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg131_5"
                     /sec_met_domain="IlvN (E-value: 9.8e-49, bitscore: 154.2,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 2.2e-44, bitscore: 140.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVMNFGGVDENVVTREEFPLEKAREVLKDETIAVIGYGVQGPGQ
                     SLNLRDNGFNVIVGQRKGGKTWEKAVADGWVPGETLFDIEEACEKATIIQYLLSDAAQI
                     EVWPRIKKYLTPGKALYFSHGFGITYKERTNIIPPADVDVILVAPKGSGTSLRRMFLQG
                     RGLNSSYAIFQDATGKAWDRVIALGIGVGSGYLFETTFKKEVYSDLTGERGTLMGAIQG
                     LLLAQYETLRENGHEPSEAFNETVEELTQSLMPLFAENGMDWMYANCSTTAQRGALDWM
                     GPFHDATKPVFQKLYSEVACGNEAQRSIDTNSKPDYREGLEKELAALRESEMWRAGAVV
                     RKLRPENN"
     CDS             6632..9910
                     /locus_tag="ctg131_6"
                     /transl_table=11
                     /translation="MISVLLGAAGAIAANPTGPETMVVQQGNKVTGLVEDQMGPVAGAS
                     VVVKGTTIGTITDIDGKFTLDNVRRGAVIVISFVGLATQEITWNGQSILNVKLSDATQD
                     LDEVVVVAYGTAKKSTFTGSASVVKAEKLEKIMGSGFAEALQGMSAGVNVVNVQGNPGA
                     DARVEIRGIASMSGKADPLYIVDGMPYDGKLNQINPTDIESMTVLKDAAATSLYGSRAA
                     NGVVMITTKRGKSEKPRINFRGGWGTSDNAVKNPKKADPYQQLENTWYALYYDALLYDG
                     MNMQQAGDYASSQALTKQVKATKDSNGNLIYVTPFRHINENYVLHDGNGNPYMNPNLEY
                     VWDEDDWDVYKAIFSRKLRQDYSVDISGQANGGKTAYFFSGGYLDDQGYGNRQYYKRYS
                     FRTNLSTELFDWWKVAGSLSYSRHRQNLSGGASRAANFTTTLSSPWLRNEDNTGWVVSE
                     KTGERMYSYGKYTNNFFGAHILNNSGDYWDNPNDDSFDNNMGHILSAQVNTEFTLPFNL
                     KFRSALNIDDYWYRTMQYTSAVHGSGQTAPYGISILADGGYASRYNFNKRSTTWNNVLS
                     GEWMIGDHTISGLVGHEWYTWDSHYEQGWGEGIMELGKYELSNTTKNFGVSGGRDKYSL
                     LSFFGKVDYNFLNKYYLSASLREDGSSRFSSDHRWGTFWSTGGSWRISKEGFMEDLKWI
                     DNLSLRGSYGTTGNDKLIVRESNGKAGDEVLYGYQGTYESDDLYLKSGLKPSTYPTPDL
                     KWESNQQWNIGLDFSVFNRLSGTVEYYSRTSHDLLYYKELPLSAQVGSASGYNMNIGDL
                     RNSGIEITLNANILTTKDFRWDIDANMSTLKNEVTYLPTGPYTYSGTACTYKMEEGKSL
                     YEFIAPQYDGVNPETGVPGWLIRDGNGGWKRTEKQEEVTTDDFVYCGSAIPKVFGAITN
                     NFQFKGIDLSFMFYYSYGSKISDYTYKERIMNRPGVGVIQELVEDRWRQPGDADVLIPR
                     WSYNQYGATVKYADNFVFDNHYWRLRNLTLGYTLPKSLTRKALVENLRVYVTGNNLLTF
                     GPAKKRYTDPETGIMGNSYNGNAETDNGIQGSRRLYMVGIQITL"
     CDS             9929..11518
                     /locus_tag="ctg131_7"
                     /transl_table=11
                     /translation="MKRFINISFLSLVFAGMALTGCNDDLTTSSYVKVNDEDVLGNVSQ
                     LEKVLTSAYKQLYFNTDKGDRVYAGLPGFQMYVDASGADVISHTNMGGDQVTAYQYSNS
                     KTQADGNASKIWSMCYNVINRANIILTNVDAAAGDETQKKHIKGQALAMRGIQYFHLIQ
                     NYQQTYAIAKSKRGVILRTSSDDESHKGFSTVEEVYTQIVSDLTTAKTLLADYNPDDMW
                     LINSKICSGILARVYLVMQNWDGAYNEAKIVYDQHSQLMTREQYRSGFDDMISGNYAEV
                     VWAMKYTADNNLGGSTQFNFWYNQDASYGEGYADGPIYSFLDYFVDEQFVKLFEEKEDR
                     YQFWKRTNNANTEINTKWAFDKYKHYGEDGGSVIQSATRPEVCLMRGAEMLLIMAEAAA
                     QKGNSGEALNLLNRLQVARNATPTTNAGGEALLEDIYVERRKELICEGQAGFYDLVRLQ
                     KRLVRIGESTTNPAGHYVWGMQYLNGYNALDPQPIGTLESNDYRFFCQIPQMEILNNDA
                     ISESDQNPWSGQ"
     CDS             12187..12291
                     /locus_tag="ctg131_8"
                     /transl_table=11
                     /translation="MNIMSVNGLWRKQTYFLFVHSRKGKHTFINITDI"
ORIGIN
        1 catattattc tcgtggtggt ccttctagtc attagtaggt aaggagaaag gtgtgtaaga
       61 agttgtgaag tcgtaaaaga tatttcttaa gcctttctcc atatagagaa gggctttttt
      121 attgactaaa agataaaaac agatatgatg aagaatccgt taagaagctc ctatagcaca
      181 gaaggcagac gtatggccgg agcccgtgca ttatggcgtg ccaacggcat gaaagaagaa
      241 cagttcggta aaccgatcat tgccattgtg aattcattta cccagtttgt accgggccat
      301 gtgcatctac acgagatcgg acagcaggta aaagcggaaa tcgaaaagct cggttgcttt
      361 gccgcagaat ttaatacgat cgctattgat gacggtattg ctatgggaca cgacggaatg
      421 ctttattctc tgccttcccg cgacatcatt gctgacagtg tggaatatat ggtgaatgcg
      481 cataaggctg atgcaatggt ttgtatcagt aactgcgaca agattactcc gggtatgctg
      541 atggccagta tgcgtctgaa tattccgaca atctttgtat ccggcggtcc gatggaagcc
      601 ggtaatctgg acggacgtgc actcgatttg atcgacgcca tgattgaagc ggctgacgat
      661 tctatcagcg atgaacaagt agaaaaggtg gaacgttccg cttgcccgac ctgcggttgc
      721 tgttctggta tgttcacggc taactctatg aactgtctga acgaagcgat tggattggct
      781 cttcccggca acggaacagt tgttgcaaca catgccaacc gtacccgcct gttcaaaaaa
      841 gccgcgaaga tgattgttga taatgccttt aaatattatc gtgacggcga tgattccgta
      901 ttgcctcgca gtattgccac ccgtcaggcc tttctgaatg ctatgtcgct ggatattgcc
      961 atggggggat cgacgaatac agtccttcac ctgttggccg tggctcatga agcggaagtc
     1021 gattttacaa tgaaagacat cgatatgctt tcacgcaaaa caccggttat ctgtaaagtg
     1081 gctccgagtt gttcttatca tgtggaagat gtgaaccgtg ccggaggtat tatcggtatt
     1141 atgaatgagc tggtaaaagc cggtctggtg gacggttccg tgaaacgtgc ggatggtctg
     1201 actttgaatg aggctatcga ccaatactgc attacctctg taaatgtaac ggaagaagca
     1261 atcaatattt ataaaagtgc tccggcccac cgtttcaatc tggtgctcgg atcgcaggaa
     1321 agttattata aagaactgga taccgaccgt gcaaccggat gtatccgcga tgtggaacat
     1381 gcttatgtga aagacggcgg tctggctgtt ctgtatggaa atattgcaca ggacggttgt
     1441 gtggttaaaa cagccggggt agatgaaagt atcttccgtt ttgccggccc tgccaaagta
     1501 ttcgattcgc aggatgccgc ttgcgaaggt atcctgaaag atcaagtcgt ctccggcgat
     1561 gtcgtcgtta tcacctatga aggtcctaag ggtggtccgg gtatgcagga aatgttgtat
     1621 cctacctctt atataaagag taaacatctg ggtaaagaat gtgcgttaat cacagacgga
     1681 cgcttcagcg gtggaacatc gggtttgtca atcggacata tttctcccga agcggctgca
     1741 ggcggagcga ttggcttagt gaaagacggc gatattatcg aaattaatat tcccgaaaga
     1801 accatacatg taaaggtgac agacgaagaa ctggccaaac gccgtgaagc ggaagaagcc
     1861 cgcggaacaa aagcctttac acctcctttc cgccaacgta cggtatcgaa agcactgaaa
     1921 gcatatgcaa agatggttgc ttcggccgat aagggcggtg tacgaatagt agaagattaa
     1981 taaacaccaa atactatatt ttagagatgg acaaacaaaa gataaccggt tcggaagctt
     2041 tgctgaaagc gctgatcgct gaaggagtag atactatctt cggttatccg ggtgggcagg
     2101 cgataccaat ttacgatagt ttatacgatt acagagatca gttaaaacat attctggtgc
     2161 gccacgaaca aggtgcaaca catgctgcac agggatatgc ccgtgtttcc ggaaaagtgg
     2221 gagtaacggt ggttacttcg ggtcccgggg caaccaatac catcactggt attgccgatg
     2281 cgctgatgga cagtacaccg atggtggtga ttgccggcca ggttccgtct ccgctgcttg
     2341 gaacagatgc tttccaggaa gttgatgtga tcggtatcac acaaccgatt accaaatggg
     2401 cttaccagat acgccgcccg gaagaaattg cttgggccgt ttcccgtgct ttctatatcg
     2461 catcgaccgg tcgcccggga cctgtggtac tggatttggc gaaagatgca caggtgggtt
     2521 tggtagatta tgagtatcag aaagtggatt atgttcgtag ttaccaacct gaaccggata
     2581 tcagggagga acgtatcgag gcggctgctt cattgataaa taatgccaaa aagccattct
     2641 gtctggtagg gcagggggtt atcctgggag gagctgaaga agaactgaaa gaattcttgt
     2701 tgaaaaacga tataccagcc ggttctaccg tattgggctt gtctgcatta ccttcggact
     2761 tcccattaaa taaaggtatg ttggggatgc atggaaatgt cggaccgaac cgcaagacaa
     2821 acgaatgtga cgtgctgatt gctatcggta tgcgtttcga tgatcgcgta accggcgacc
     2881 tgaagactta tgccaagcag gcaaagatta tccacctgga tatcgacaat tcggagatcg
     2941 gaaagaatgt gccggtcgac gtgaaagtgc tgggaaatgc caagcatacg attccgatga
     3001 ttacggcttt actggaagaa cggaagcgtc cggaatggaa tgctgaattc gaaccggatg
     3061 aaaaagagga atataataag gtaatagaaa aagaactcta tcctaccgaa ggccaactga
     3121 aaatgggcga agtagtccgt aaggtttccg aagcaaccga taatgatgcg attctggtta
     3181 cggatgtagg tcagaaccag atgatgggtg ttcgctattt caaatataaa caaacacgca
     3241 gcgtagttac ttcaggaggt ttgggaacga tgggctttgg ccttcccgcc gccattggag
     3301 cgaagctggg agcgcctgac cgtacggtct gtttctttac cggcgacggt ggtatccaga
     3361 tgactatcca ggagttggga actatcatgc aggaaaatct gaatgtaaag atcatcgttc
     3421 ttaacaacaa tttcctggga atggtacgcc agtggcagga gctgttcttc aacgaacggt
     3481 attcgaatac catcatgaag aatccggatt ttgtagcgat agccaaggct tttggtattg
     3541 cttcccgtgc ggtagataaa cgggaagact tggatgaggc gattgctgaa atgttgaatc
     3601 acgatggtgc ctatatgttg gttgccaatg tggaaacttg tggtatggta tatccgatgg
     3661 ttccggccgg aggaagcgtg acaaacatga ttttgggtga taagtaagga ggagaaacta
     3721 tgaatacaaa acaattatat accgttatta tcttttcgga aaacactgtt ggtcttctga
     3781 atcagataac tgttatcttt acgcgccggc aactgaacat tgagacgctt tctgtttctc
     3841 cctctgctat aaagggaata cataagttta caattactac ctttgccgac gaggatacga
     3901 tcgacaaggt cgtaaaacag atcgacaagc gtgtggatat cctgaaagcc tattataata
     3961 cggatgaaga cctggtttac caggaaatcg ctctttataa actgagtacc gaactcttta
     4021 tcaagatggg gacggttgag gatctgatcc gtaagtacaa tgcccgtatc cttgaaatga
     4081 atgaggattg tgtggtgttg gaaaagagtg gtcattatga tgagacacag gctttgttta
     4141 aagaattgag tgagacgatc ggtgtcctgc aatttatccg ttccggacgc gttgctataa
     4201 cgaagagtaa ggtagaacgt ctgagcgaca tgttatctgc aatggaaaag aagttgcagg
     4261 aaaaacatgt ctgagaataa taaggaaaca ttttgtaaat aaagtaaatt atggagaaga
     4321 acaaagtagg agaatttcat ttcgtaacag agtcttatct gacggacttc cggggacgta
     4381 ttacaatccc tatgatcgga acttatttgt tgcatgctgc ttcttgccat gccgccgacc
     4441 gtggattcgg atataacgat atgaccgaaa ggcataccgc ctgggttctt tcccgtctgg
     4501 ctatcgagat gacttcttat cctgccatgt ctgaatccgt aactttatat acctgggtgg
     4561 atgaggtcgg taagttgttt accagccgtt gctttgaact ggtgaacggc gaaggcaaga
     4621 cctttggctt tgcccgctct atctgggcgg ctatcgatat ggaaacccgc cgcccgacct
     4681 tgctcgatgt ggagggcctg agtgcttata tcaccgaccg tccctgtccg attgaaaaac
     4741 cgggtaaaat tgctccggtg gaaaacaaca cttccggcga accttaccgt gtgaagtata
     4801 gtgacctgga cgtaaacggc cacctgaaca gtatcaaata catggaacac ctgctcgact
     4861 tgttcgatat cagtctgttc cgagaaaaag agataagccg tttcgaaata gcttatcagt
     4921 ccgaaggaaa gtatgggatg gagctgactc tccataacca ggaagtatcc ctcgataaat
     4981 ataatatggc aatctgtaac gacggcaaag ccatcagccg cgctgccgtt acctggatct
     5041 gaaaaacaaa ttattttata tacattttaa tagtaaaaag aaaatggcag taatgaattt
     5101 tggcggcgtt gacgaaaacg tagtaacccg cgaagaattt ccgttggaaa aggcaagaga
     5161 agtattgaaa gacgaaacaa tcgctgtaat aggttacggc gtacaaggtc ctggccagag
     5221 cctgaacctg cgcgacaacg gttttaacgt aattgtagga caacgtaaag gtggtaagac
     5281 ctgggaaaag gccgttgctg acggttgggt accgggcgaa acactgttcg atatcgaaga
     5341 agcatgcgaa aaagcaacta tcatccagta tctgctttca gatgctgctc agattgaagt
     5401 ttggccgcgc atcaaaaaat acctgactcc gggtaaggct ttgtatttct ctcacggatt
     5461 cggtatcact tacaaagaac gtacaaacat catccctcct gctgatgtag acgtaatcct
     5521 ggttgctccg aaaggttcag gtacttcact gcgccgtatg ttcttgcagg gtcgtggtct
     5581 gaactcaagc tacgcaatct tccaggatgc aacaggcaaa gcatgggatc gcgtgattgc
     5641 actgggtatc ggtgttggtt ctggttactt gtttgaaaca acattcaaga aagaagttta
     5701 ttctgacctg accggcgaac gtggtacttt gatgggagct atccagggat tactgttggc
     5761 tcagtacgaa actttgcgtg aaaacggtca cgaaccttct gaagcattca atgaaacagt
     5821 agaagaactg actcagtcat tgatgccgtt gttcgcagaa aacggtatgg actggatgta
     5881 tgcaaactgt tcaacaactg cacagcgtgg tgctttggac tggatgggcc cgttccacga
     5941 tgctacaaaa ccggtgttcc agaagttgta tagcgaagtt gcctgcggta acgaagcaca
     6001 gcgttctatc gacacaaaca gcaagcctga ctatcgtgaa ggtctggaaa aagaactggc
     6061 tgctcttcgc gaaagtgaaa tgtggcgtgc aggtgctgtt gttcgtaaac ttcgtcctga
     6121 aaacaactaa taaatggtga tacattaata gttaaacatt ttgtgatata aaaacggcaa
     6181 tccggctttt cgggttgccg tttttttatg gtttatgtaa tgcgttaatg gttaaaaaat
     6241 gtttttgatt gcaactgtta ttgatttttc atcccaatat gtatgtcatt gtttgaatgt
     6301 ggattttaga taaaaaaatc aattaaatgg tggttaaaat atatttatta gagcaataaa
     6361 tatacataat tatgcttgta ttaaataatg ataagttata tttgctgatg gagatactgt
     6421 agtttgtaga gtggaaatat agaaggatgt tgtgtgtaat gatcagtata tctttgtttt
     6481 agttaacttt attttattga aatgtatgcc agtcactttt atcttagaaa agtgtaacct
     6541 ctaatgaaat gaacgctatt gtgattaatt ttatttaatt aaagacttga atttagctat
     6601 gtggaccaac tcaaaactaa ttagatcact aatgatttct gtattattag gtgcggcagg
     6661 tgcgattgct gccaatccta caggtccgga aacgatggta gtacaacagg gtaataaggt
     6721 aaccggcctg gtagaggacc agatgggacc tgtcgccgga gcttctgttg tagtgaaagg
     6781 aaccactatc ggtacgataa ccgatatcga tggaaagttt acgctggata atgttcggcg
     6841 gggagcggtt attgttattt cctttgtcgg cctggccact caggagatca cttggaacgg
     6901 acaatctatt ttaaatgtaa aattaagtga tgcgacacag gacctggatg aagtcgttgt
     6961 cgtagcctat ggaacggcta agaaatcaac cttcaccgga tcggcctccg ttgtaaaagc
     7021 tgaaaaactc gaaaagatca tgggctccgg ctttgcggaa gcattgcagg ggatgagtgc
     7081 cggtgtgaat gttgtgaatg tacagggtaa ccccggagct gatgcccgtg tggagatccg
     7141 tggtattgct tccatgtccg gaaaggccga tccgttatat attgtggacg ggatgcctta
     7201 cgatggaaaa ctgaatcaga tcaatcctac ggacatagaa tcgatgacgg tgctgaagga
     7261 tgcggcggcc acttcgctct acggttcgcg tgcagcaaac ggcgtcgtaa tgattacaac
     7321 caagcggggt aaatcagaaa aaccgcgtat taacttccgc ggaggttggg gtacttcgga
     7381 taatgctgtc aagaatccga aaaaagccga tccgtaccag cagctggaaa atacctggta
     7441 tgccttgtat tatgatgccc ttctttatga cggcatgaat atgcaacagg cgggcgatta
     7501 tgcttcgtcg caggcattga ccaaacaggt aaaggctaca aaagattcga atggtaatct
     7561 gatttatgtc actccgttca gacatatcaa tgaaaattac gtattgcatg acggcaatgg
     7621 gaatccttac atgaatccta atctggaata tgtctgggat gaagatgatt gggatgtcta
     7681 caaagctatc ttctcccgta aactgcgcca ggattatagt gtggatataa gtggtcaggc
     7741 caatggtgga aaaacagcct atttcttctc cggcggttat ctggacgacc agggatatgg
     7801 taaccggcag tattataaac gttattcttt ccgtaccaac ctgagtacag agttgttcga
     7861 ttggtggaaa gtggccggta gcctttctta ttcgcgtcat cgccagaacc tttccggtgg
     7921 tgccagccgt gcggctaact ttacgacgac tttgtcttca ccctggttac gtaatgaaga
     7981 taataccggt tgggtcgttt ctgaaaaaac aggggaacgg atgtacagtt acggtaaata
     8041 taccaataac ttctttggtg cccatatcct gaataactcg ggtgattatt gggataatcc
     8101 gaacgatgac agtttcgata acaatatggg gcatatcctg tctgctcagg taaatacaga
     8161 gtttactctt cctttcaacc tgaaattccg ttcggctttg aatattgacg attactggta
     8221 tcgtaccatg caatatactt ccgccgtaca tggcagcgga cagactgcac cttatggtat
     8281 ttctatactg gcagacggtg gttatgccag ccgttataat ttcaataaac gttccaccac
     8341 ctggaataat gtattgtctg gtgaatggat gattggtgac catacgattt caggtctggt
     8401 cggacatgag tggtatacct gggactccca ctacgaacaa ggttggggtg aaggtatcat
     8461 ggaactgggt aaatatgaat tatcgaatac caccaagaac ttcggtgttt ccggcggacg
     8521 tgataaatac tctctgcttt cgttctttgg taaggtcgat tataacttct tgaataagta
     8581 ttacttgtcc gcttcacttc gtgaggatgg ttcttcccgt ttcagctccg atcatcgctg
     8641 gggtacattc tggtcgacag gcggttcatg gcgaatatcg aaagaaggtt ttatggaaga
     8701 cctgaaatgg attgataacc tttcgttgcg tggtagttac ggtacgactg gtaatgataa
     8761 gctgatcgtg cgtgaatcga atggtaaggc aggggatgaa gtcctttacg gataccaggg
     8821 tacttatgaa agtgatgacc tgtatctgaa atccggttta aaaccatcta cctatccgac
     8881 accggacttg aagtgggaaa gtaatcagca atggaatatc ggtttagatt tttccgtatt
     8941 caaccgactt agcggtacag tggaatatta ttcccgtact tcccatgact tgttgtatta
     9001 taaggaactg cctctctctg cccaggttgg tagtgcatcc gggtataata tgaatatcgg
     9061 tgacctgcgt aatagcggga ttgaaatcac attgaatgcg aatatcctta caacgaaaga
     9121 tttcagatgg gatatcgatg ccaacatgag tacgctgaaa aatgaggtga cttatttgcc
     9181 tacaggtcct tacacttatt ctggtaccgc ctgtacctac aagatggagg aaggcaagtc
     9241 tctgtatgaa tttatcgctc cccagtacga cggtgttaat ccggaaaccg gagtacccgg
     9301 ctggttgatc cgcgatggta acggcggttg gaaacgtacg gaaaagcagg aagaagtaac
     9361 gacagacgat tttgtgtact gtggctccgc gattcccaaa gtgttcggtg ctatcaccaa
     9421 taacttccag ttcaaaggga tcgacctgtc gttcatgttc tattattctt atggttccaa
     9481 aatatcggac tatacatata aagaacgtat catgaaccgt ccgggtgtcg gtgtgataca
     9541 ggagttggtt gaggacagat ggcgtcagcc gggcgatgcg gatgtgctta tcccacgttg
     9601 gtcgtacaac cagtatggcg cgacggtaaa atatgcagat aacttcgtat tcgacaacca
     9661 ctactggcgt ctgagaaacc tgacattagg ctatacgctg cctaagagcc ttacccgcaa
     9721 ggccctggta gaaaacctgc gtgtttatgt aaccggtaat aacctgttga ctttcggtcc
     9781 tgccaaaaaa cgctacacag accccgaaac aggtataatg ggtaacagtt ataacggtaa
     9841 tgctgaaacc gataacggta ttcagggttc gagaagactg tatatggtcg gtattcaaat
     9901 cacattgtaa acgtaaaaaa tgatatttat gaaacgattt ataaatatat ccttcctgtc
     9961 cctggttttt gctggtatgg ccctgaccgg atgtaacgac gacctgacaa ccagctccta
    10021 cgtgaaagta aacgatgaag atgtactggg gaatgtctcc cagttggaaa aagtattgac
    10081 ttcagcctat aagcagctgt attttaatac tgataaagga gaccgtgtgt atgccggtct
    10141 tcccggattc cagatgtatg tcgatgcgag tggtgccgac gtgatcagcc ataccaatat
    10201 gggaggtgat caggtaacag cataccagta ttccaactca aaaacacagg ctgacggaaa
    10261 tgcctcaaaa atctggtcga tgtgctataa tgtgatcaac cgtgccaata tcatcctgac
    10321 caatgtggat gccgccgccg gtgatgaaac acagaaaaaa catatcaaag gccaggcgtt
    10381 ggcgatgcgt ggaatccagt atttccatct gatccagaat taccagcaga cgtatgcgat
    10441 agctaaaagc aagcgtgggg tgatcctgcg tacctcttcc gatgatgaat cccataaagg
    10501 tttttctact gtagaggaag tctataccca gattgtgtcc gacctgacga cggctaaaac
    10561 attgcttgcc gattataatc cggacgatat gtggctgatc aactccaaaa tatgttcggg
    10621 aatcctggcc cgtgtttatc tggtgatgca gaactgggac ggcgcttaca atgaagccaa
    10681 gatcgtctac gaccagcaca gccagttgat gacccgcgaa caataccgtt ccggtttcga
    10741 cgatatgatc tccggcaatt atgcggaagt ggtatgggcc atgaaatata ccgccgataa
    10801 taacctgggc ggtagtacgc agttcaattt ctggtataac caggatgcca gctacggcga
    10861 gggttatgcc gatggtccta tctactcgtt ccttgactac ttcgtggatg agcagtttgt
    10921 gaaactattt gaagaaaaag aagaccgtta ccagttctgg aaacgtacga acaatgcgaa
    10981 tacggaaatc aatacaaaat gggctttcga caaatacaag cattatggtg aagacggcgg
    11041 aagcgttatt caaagcgcca cccgtccgga agtctgcctg atgcgcggag ccgaaatgct
    11101 gctgattatg gcggaggctg ctgcccaaaa gggtaactcc ggcgaggctc tgaatctgct
    11161 gaaccgtttg caggtggcgc gtaatgctac cccgacaacc aatgccggag gcgaagcttt
    11221 gctggaagac atctatgtgg aacgccgtaa agagttgatc tgtgaaggac aagccggttt
    11281 ttatgacctg gtgcgcctgc aaaagagatt ggttcgtatc ggtgaatcaa ctaccaatcc
    11341 tgccggacat tacgtatggg gcatgcagta tctgaacgga tataatgcgc tcgatccgca
    11401 accgataggg acgctggagt cgaacgatta ccgtttcttc tgccaaatcc cgcaaatgga
    11461 aatcctgaat aatgatgcga tctccgaatc agatcagaat ccgtggagcg ggcagtaagt
    11521 ttcatctgtt gtaaataaat aaaagagagg gaggtgttta ttacatgcct ccctctcttt
    11581 tatttgtaac atttgatgtt cactgtttta ctttttgtcc tttagcactt cctgtaacat
    11641 ggccaccttc tcctgctccg ctttcaataa acgttcgtat aattcaacga ctttttctaa
    11701 ggggttaaat gtaggattat aattctggca attagcatta tcttgccagg tgccggaaaa
    11761 gatattaatg gaagtggctt cgcctagttc cgtaattgct tcttcgggta tatctaatgc
    11821 tttggcaatc ttttcgatta cttccggctc cagattactt cttttttcgt atgtcgaaag
    11881 ggttagtaga aaataaatcc ggtttatctc tcataataaa tatcggaaag agttgcctga
    11941 taatatttgt accacagaaa aaacacatca aaggtcaggc gctggcgatg cgtggaatcc
    12001 agtattttca cctgatccag aattaccagt aaacgtatgt cattgcgaaa aatagtttct
    12061 ctttcaaccg ataatagtgg acatgatatc agtgaaacgg ttgatgcaaa tcagtgtcgt
    12121 atggaaactt cacttcctgt aaccaaacag acggcaaaat caaaatgata taaaaatgaa
    12181 tgatatatga atattatgag tgtaaatggc ctttggagga aacagactta ttttttattt
    12241 gttcattcta gaaaagggaa gcatacattt attaacataa cagatatctg atatcgactt
    12301 tttatctcgt ttaaaccgaa gaaaatttta gtttaaacag atttcaattt cgtttaaact
    12361 gagataaatt tctattgtag tggagttttt attcgtttag agaagaaaaa cacctcaatt
    12421 agtgctttta aaaaagaaaa tcatatgttt ttagacagtt tttatttcca gagcaaccgc
    12481 tttttgatgt gtgtgtaaaa tagcaatatg ttaataaatt atgaatagat gtggtatatg
    12541 ggtaacaatc atagataata tacatttttt gtgatatgaa tattgcaaca atcaggtcaa
    12601 agcgaacaaa ggtaagtcgg cgagatttct ataaaaacag atcgacattt ccctttgccc
    12661 gtacaattcc ttcagcacat acataaaata tcattttgac aatcctttaa cttccaggaa
    12721 ctctcctgac gctttgtatc caatagtatg ttctccggat aggacttggc ttttatatcc
    12781 caaaaagtaa atcatcaata gtaaacaagg caaccgcagc aaaaggatgt ttcaatatag
    12841 aaatatttga actatcccgt tcccgtgctc gacacgggat cgcaaaagca ca
//
