LOCUS       c00070_gnlPro..        16401 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  gnl|Prokka|KGGOFMJL_70.
ACCESSION   c00070_gnlPro..
VERSION     c00070_gnlPro..
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2024-10-05 11:27:56
            Original ID  :: gnl|Prokka|KGGOFMJL_70
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 16401
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             1..666
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_1"
                     /sec_met_domain="OAD_beta (E-value: 1.6e-83, bitscore:
                     270.5, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="PIAIAAYSYMALVPVIIPLVVKLFCTKKELSINMKEQEKKYPSKT
                     EIKNLRVLKIIFPIVVTTIVALFVPSAVPLIGMLMFGNLVKEIGSNTFRLFDAASNSIM
                     NAATIFLGLSVGATMTAEAFLNWTTIGIVIGGFLAFALSITGGIFFVKLVNLFSKKKIN
                     PLIGATGLSAVPMASRVANEIALKYDPKNHVLQYCMASNISGVIGSAVAAGVLISFLA"
     protocluster    1..16401
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[0:14773]"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      1..14773
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /neighbourhood="10000"
                     /product="succinate2propionate"
                     /protocluster_number="1"
     cand_cluster    1..16401
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(minimum(4, [AcetylCoA_hyd_C,
                     AcetylCoA_hydro, B12-binding, Biotin_lipoyl, Glyoxalase_4,
                     HMGL-like, MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma,
                     PYC_OADA]) and minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /kind="single"
                     /product="succinate2propionate"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..16401
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="succinate2propionate"
                     /region_number="1"
                     /rules="(minimum(4, [AcetylCoA_hyd_C, AcetylCoA_hydro,
                     B12-binding, Biotin_lipoyl, Glyoxalase_4, HMGL-like,
                     MM_CoA_mutase, MeaB, OAD_beta, OAD_gamma, PYC_OADA]) and
                     minimum(1, [CT_Btheta, CT_Propionyl_CoA1,
                     CT_Propionyl_CoA2, CT_Propionyl_CoA3, CT_Vparvula]) and not
                     Cytidylate_kin)"
                     /tool="gutsmash"
     CDS             complement(782..2062)
                     /locus_tag="ctg70_2"
                     /transl_table=11
                     /translation="MKEMKTQLILFSLLLLGSTAWAQQPCLSQDAYREKVEAYSQILKQ
                     QKLKTLASSEARKIAHTGFLPKIDVNADGTLNMSDLSAWNEPVGEYRNHTYQGVFVVSQ
                     PLYTGGALNAQHQIAKADEKLNQLNEELTLDQIHYQSDAVYWNASASKAMLQAADKYQS
                     IVKQQYDIIQDRFDDGMISRTDLLMISTRLKEAELQYIKARQNYTLALQQLNILMGEAP
                     NTPVDSLYNIGMISAPVRILPLEDVLQRRADYASTEVNIMKSQAQRKAALSQFNPQLNM
                     YFSGGWATATPNLGYDVSFNPIVGVNLNIPIFRWGARFKTNRQQKAYIGIQKLQQSYMT
                     DNINEELSAALTKLTETESLVKTAKENMSLANENLDLATFSYNEGKASMVDVLSAQLSW
                     TQAHTNLINAYLAEKMAVAEYKKVTSE"
     CDS             complement(2120..4456)
                     /locus_tag="ctg70_3"
                     /transl_table=11
                     /translation="MYANIDDIRNQVITTKAGQVKLGDIAVIEKGYLDPPSNIMHVNGK
                     RAIGIGVSTDPQRDVVQTGENVKVKLNELLPLMPVGLELQSLYLENEIANEANNGFIIN
                     LIESILIVIVIIMLVMGLRAGLLIGSSLIFSIGGTLLIMSFFGVGLNRTSLAGFIIAMG
                     MLVDNAIVVTDNAQIAIARGINRRKALIDGATGPQWGLLGATFIAICSFLPLYLAPSAV
                     AEIVKPLFVVLAISLGLSWVLALTQTTVFGNFILKAKTGDSTKDPYDKPFYHKFASVLG
                     VLIRKKAVTLVSMVILFIISLIIMGTMPQNFFPSLDKPYFRADVFYPDGYSINDVVKEM
                     KSVEEHLAKQPEVKKVSITFGSTPLRYYLASTSVGPKPNFANVLVELTDSKYTKEYEED
                     FDGYMKANYPSAITRTSLFKLSPAVDAAIEIGFIGPNVDTLVSLTNQAIAIMHQNPDLI
                     NIRNSWGNKIPVWKPVYSPERAQPLGVSRQGMAQSIQIGTTGMTLGEYRQGDQVLPILL
                     KNNQLDSFRINDLRTLPVFGTGNETTSLEQVVSEFDFQYRFSNVKDYNRQMVMMAQCDP
                     RRGTNAISAFNQVWSQVQQEIKIPEGYTMKYFGEQESQVESNEALAKNLPLTFFLMFVT
                     LLFLFKTYRKPTVILLMLPLIFIGIVLGLLVLGKSFDFFSILGLLGLIGMNIKNAIVLV
                     DQIDLETAAGKKPLDAVISATTSRIIPVAMASGTTILGMLPLLFDAMFGGMAATIMGGL
                     LVASALTLFVLPVAYCAIHRIKGEQ"
     CDS             complement(5165..6217)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Biotin_lipoyl_2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg70_4"
                     /sec_met_domain="Biotin_lipoyl_2 (E-value: 1.7e-12,
                     bitscore: 37.1, seeds: 52, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNIYVIALAAILFQGCGQKKEMTAPATRPVKTTIVESRSVIRKD
                     FSGIVEAVEYVKLAFRVSGQIISLPVIEGEKVKKGQLIAAIDPRDIALQYAATKSAYET
                     ASAQVERNKRLLSRQAISVQEYEISLSNYQKAKSEYELSSNNMRDTKLTAPFDGSIEKR
                     LVENYQRVNSGEGIVQLVNTQNLRIKFTIPDAYLYLLRAKDPRFLVEFDTFKGHVFKAR
                     LEEYLDISTEGTGIPVSITIDDPSFDRDLYAVKPGFTCSIRFTADVGPLVQDSWTIIPL
                     SAVFGESDGNNMYVWVVEDNKVHKRKIVVNAPTGEAQVLVSEGLKPGEQIVIAGVYQLV
                     EGESIKSIDK"
     CDS             complement(6847..7131)
                     /locus_tag="ctg70_5"
                     /transl_table=11
                     /translation="MKKGLHPESYRPVVFKDMSNGDMFLSKSTVATKETIEFEGETYPL
                     LKIEISNTSHPFYTGKSTLVDTAGRVDKFMSRYGDRKKXXXXRNNSIFR"
     CDS             7532..8536
                     /locus_tag="ctg70_6"
                     /transl_table=11
                     /translation="MVNYKDLGLVNTRDMFAKAIKGGYAIPAFNFNNMEQMQAIIKAAV
                     ETKSPVILQVSKGARQYANATLLRYMAQGAVEYAKELGCAHPEIVLHLDHGDTFETCKS
                     CIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVSSDHHT
                     YTDPEEVIDFATRTGCDSLAISIGTSHGAYKFTPEQCHIDPATGRMVPPPLAFEVLDAV
                     MEKLPGFPIVLHGSSSVPEEEVETINKFGGALKAAIGIPEEELRKAAKSAVCKINIDSD
                     SRLAMTAAIRKTFAEKPAEFDPRKYLGPARDNMEKLYKHKILNVLGSDNKLAE"
     CDS             complement(8615..9949)
                     /locus_tag="ctg70_7"
                     /transl_table=11
                     /translation="MKRIILLAFLCTTTLVMAQRINHVQEAIANYDYEAALTLIAKEKP
                     TIPLLLQKGKAQRGLGMNTEALSTYQEIITNDTANTRAYIEAAECCRSLAKYQQALKYY
                     EQALDLNPENKYVRIQYIGLLLSLQKFQDALGESSLMTEKDSSAIALHLQAQSFEGMGE
                     LLPATGCYYNIQEKYPDDYLAAAKLAALNIAGSYFNEAIEATEKYRQIDTTNIAVNRQN
                     ALAYCLNKDYPTAIQRYEYLVSQGDSSFHTCYYLGISYYAEEKYYEAHDFLEAARKHDP
                     ENVNLLYYLGRACAKTSWKKLGVEYLEKALDLTIPKDSNMVRLYIGMTDCYKMAQMPKE
                     QIESIRERYRKYDKQNHKLLYDMAFIYFYSLKDKKNTERCLEAFLKTRPKEDKEEEAKL
                     NERGELVLGTKNYYNAAANWLKDIQSKQKIEDFFLGGNVPAQKPE"
     CDS             complement(10163..11323)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_beta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_8"
                     /sec_met_domain="OAD_beta (E-value: 1.6e-153, bitscore:
                     500.7, seeds: 229, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDFINFLGNNLADFWTYTGFANATGGHIAMIIIGLGFIYLAVAK
                     EFEPMLLIPIGFGILIGNIPFNMDAGLKVGIYEEGSVLNILYQGVTSGWYPPLIFLGIG
                     AMTDFSALISNPKLMLIGAAAQFGIFGAYMIALEMGFDPMQAGAIGIIGGADGPTAIFL
                     SSKLAPNLMGAIAVSAYSYMALVPVIQPPIMRLLTTKHERVIRMKPPRAVSHTEKVIFP
                     IIGLLLTCFLVPSGLPLLGMLFFGNLLKESGVTRRLANTASGPLIDVITILLGLTVGAS
                     TQASEFLTLDSIKIFALGALSFIIATASGVIFVKIFNLFLKKGNKINPLIGNAGVSAVP
                     DSARISQVVGLEYDPTNYLLMHAMGPNVAGVIGSAVAAGILLGFLM"
     CDS             complement(11325..11462)
                     /locus_tag="ctg70_9"
                     /transl_table=11
                     /translation="MQTKTVRSEEHTSEXXXXDKDGKVTAINVNKGDSVLEGNDLVIIE
                     "
     CDS             complement(11422..11808)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Biotin_lipoyl"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_10"
                     /sec_met_domain="Biotin_lipoyl (E-value: 9.9e-17, bitscore:
                     50.7, seeds: 40, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKEYKYKINGNSYKVTIGDIEDNIAHVEVNGTHYKVEMEKQPKAT
                     PKPAVVRPMPNSPAAPTTPVVKPAAPSTGKSGVKSPLPGVILDIKVNVGDTVKRGQTII
                     ILEAMKMENNINADKDGKIGRAHV"
     CDS             complement(11833..12753)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: OAD_gamma"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_11"
                     /sec_met_domain="OAD_gamma (E-value: 2.9e-14, bitscore:
                     43.5, seeds: 234, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNKTKIGIFLSLLLLIGLTSCGEQKSNNKLLLNEVLIDNQNNFQD
                     DYGLHSAWIEIFNKSYGSADLAACLLKVSSQPGDTVTYFIPKGDILTLVKPRQHALFWA
                     DGEPNRGTFHTSFKLNPETANWVGLFDSGRKLLDQVVIPAGTLGPNQSYARISDGAADW
                     EVKGGSKDKYVTPSTNNKTLDSNAKMEKFEEHDSVGIGMSISAMSVVFCGLILLFIAFK
                     VVGKVAVNLSRRNAVKAKGIDKVEAKELSQAPGEVYAAISMALHEMQDEVHDVEETVLT
                     ITRVKRSYSPWSSKIYTLRENPNRK"
     CDS             complement(12785..14338)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: CT_Btheta"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_12"
                     /sec_met_domain="CT_Btheta (E-value: 4.9e-291, bitscore:
                     955.2, seeds: 72, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSNQLEKIKELIERRAVARIGGGEKAIAKQHEKGKYTARERIAML
                     LDEGSFEEMDMFVEHRCTNFGMEKKHYPGDGVVTGCGTIEGRLVYLFAQDFTVTAGSLS
                     ETMSLKICKIMDQAMKMGAPCIGINDSGGARIQEGINALAGYAEIFQRNILASGVIPQI
                     SGIFGPCAGGAVYSPALTDFTLMMEGTSYMFLTGPKVVKTVTGEDVSQENLGGASVHST
                     KSGVTHFTAKTEEEGLALIRTLLSYIPQNNLEEAPYVDCTDPIDRLEDSLNDIIPDSPN
                     KPYDMYEVISAIVDNGEFLEIQKDYAKNIIIGFARFNGQSVGIVANQPKFLAGVLDSNA
                     SRKGARFVRFCDAFNIPIVSLVDVPGFLPGTGQEYNGVILHGAKLLYAYGEATVPKVTI
                     TLRKSYGGSHIVMSCKQLRGDMNYAWPTAEIAVMGGAGAVEVLYAREAKDQENPAQFLA
                     EKEAEYTKLFANPYNAAKYGYIDDVIEPRNTRFRVIRALQQLQTKKLSNPAKKHGNIPL
                     "
     CDS             complement(14369..14773)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     succinate2propionate: Glyoxalase_4"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg70_13"
                     /sec_met_domain="Glyoxalase_4 (E-value: 1.6e-24, bitscore:
                     76.4, seeds: 51, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKISHIEHLGIAVKSIEEALPYYENVLGLKCYNIETVEDQKVRTA
                     FLKVGETKIELLEPTCPESTIAKFIENKGAGVHHVAFAVEDGVANALAEAESKEIRLID
                     KAPRKGAEGLNIAFLHPKSTLGVLTELCEH"
     CDS             complement(14947..15945)
                     /locus_tag="ctg70_14"
                     /transl_table=11
                     /translation="MPLKLTTYYRGKDIPDLPGTNTFHSKELFQIYESTPGYTPLLIVA
                     TEEGRPVARLLAAIRKTKKWLPSSLVKQCVVYGAGEFLDTSLPASKEKEEEIFGEMLEH
                     LTQEASRTCILIEFRNLDNSMFGYRFFRKNDFFPVNWLRVRNSLHSTQKAEDRFSPSRI
                     RQIRKGLKNGAKVVEAHTVEEIKEFSRMLHKVYSSRIRRYFPANDFFRHMNSMLIRGKQ
                     AKIFIVKYKEKIIGGSVCIYSGENAFIWFSGGMRKTYALQSPGILAVWKALEDAHERGF
                     RHMEFMDVGLPFRKHGYRDFVLRFGGKQSSTRRWFRISWPWLNNLLVKFYV"
     CDS             16143..16391
                     /locus_tag="ctg70_15"
                     /transl_table=11
                     /translation="LYFTKQRKININFKLKRMRENAFVEAWKTQHRRVSMILGLTLLCA
                     PSAISVYAENGVNDITVQAVMQTKTVKIGRASCRERV"
ORIGIN
        1 ccgatcgcta ttgccgctta ttcttatatg gcactggtgc ctgtgatcat tccgttggta
       61 gtgaagctgt tctgtactaa gaaagaactg agcatcaaca tgaaggaaca ggaaaagaaa
      121 tatccttcga agacggaaat caagaatctg cgtgtactga agattatttt cccgattgta
      181 gtgactacga ttgtagctct cttcgtccca agtgcagtac ctttgattgg tatgctgatg
      241 ttcggtaatc tggtgaaaga aatcggaagc aatactttcc gtctgttcga cgctgcttcc
      301 aacagtatta tgaatgccgc cactatcttc ctcggacttt cggtaggtgc aaccatgacg
      361 gctgaagcct tcttgaactg gacgacaatc ggtattgtca tcggtggttt ccttgcattt
      421 gctctttcta ttaccggtgg tatcttcttt gtgaagttag tgaatctatt ctccaagaag
      481 aagattaatc cgctgatcgg agcgaccgga ctgagcgctg ttccgatggc aagccgtgtg
      541 gcgaatgaga ttgcgttgaa atacgatccg aagaatcatg tattgcagta ttgtatggca
      601 agtaacattt caggggtaat cggctcggca gtagctgcag gtgtactgat ctccttcctt
      661 gcataataaa aagaacaacc aataaagatt aggcacggat tacgcggata aacacggttt
      721 ttagttactc aactcttaaa accgtgaaat ccgtgtcatc cgtgcctaat tttgttttta
      781 tctattcgct ggtcaccttc ttgtattcag ccacagccat cttctctgcc agataagcat
      841 tgatcagatt ggtgtgtgct tgcgtccatg acaactgggc ggaaagtaca tctaccatgc
      901 tcgcttttcc ttcattgtag gagaaagtgg ccagatccag attctcattt gccagactca
      961 tgttttcttt cgctgttttc accagagatt ctgtttccgt cagtttggtg agagctgccg
     1021 acagttcttc gttgatattg tccgtcatat aactctgttg caacttttgt attccgatat
     1081 atgccttctg ctgccggttc gtcttgaaac gggctcccca gcggaaaatg ggaatattca
     1141 gattgactcc tacgatggga ttgaaagata cgtcgtatcc caagttgggt gtggccgttg
     1201 cccagccacc gctgaaatac atgtttaatt ggggattgaa ctggctgaga gccgctttac
     1261 gttgtgcctg gctcttcatg atgtttactt ccgtactggc ataatcggca cgtcgttgca
     1321 aaacatcttc cagaggcagt atccggacag gagcggagat cattccgatg ttgtacaggc
     1381 tgtctacagg agtattcggt gcttctccca tcagaatatt cagttgttgc agcgctaatg
     1441 tataattctg gcgggctttg atatactgca gttccgcttc tttcagccgg gtggaaatca
     1501 tcagaagatc tgtacggctg atcattccgt catcgaaacg gtcctgaata atgtcatatt
     1561 gctgtttgac aatgctctgg tatttgtcgg ccgcttgtag catggctttt gaagcggagg
     1621 cattccagta gacagcatca ctttgatagt gaatctggtc taacgtgagt tcctcgttca
     1681 gttggttcag cttttcgtct gccttcgcta tctgatgttg ggcattgagc gcaccgcctg
     1741 tgtagagtgg ctgtgatacg acaaatactc cctggtaggt atggttgcgg tattcgccca
     1801 ccggttcgtt ccatgcgcta aggtcgctca tgttcagggt accgtctgca tttacgtcga
     1861 ttttcggcag gaaacctgta tgggctatct ttcgcgcctc cgaactggcc aatgtcttta
     1921 gtttttgttg tttcaatatc tggctgtaag cctccacttt ttcgcggtag gcgtcctgac
     1981 tcaggcaggg ctgttgcgcc caggctgtgg agccaaggag caacagtgaa aatagtatga
     2041 gttgggtttt catttctttc atggataatc tttttagttg acaattgaca gttgacaatt
     2101 gacaattgtc agttgatggt tattgttctc ctttgatccg gtggatggcg caataggcta
     2161 caggaaggac gaatagtgtc aatgccgagg ctactaacag tccgcccatg atggtggcgg
     2221 ccattccgcc gaacatggcg tcgaacagta gcggcaacat acccagaatc gttgttccgg
     2281 aggccatcgc taccggaatg atgcgactgg tcgtggcact gatgactgcg tccagcggtt
     2341 ttttgcctgc tgctgtttcc aaatcgattt ggtctaccag tacgatagcg ttcttgatgt
     2401 tcataccaat cagacctagc agacccaata tggagaagaa gtcgaacgac ttgccgagta
     2461 cgagcagtcc caacacgata ccgatgaaga tcagcggcag cattaacagg atgacggtcg
     2521 gcttgcgata cgtcttgaac aagaagagca gcgtcacaaa catcaggaag aatgtcagcg
     2581 gtaagttttt ggccagcgct tcattcgatt ccacctgact ttcctgttca ccgaaatact
     2641 tcatggtata tccttccggt atttttatct cttgctgtac ttgcgaccat acctggttga
     2701 aagcggaaat cgcattggtt ccgcgacgcg ggtcgcattg tgccatcatc accatctgcc
     2761 ggttatagtc tttcacgttc gagaaccggt actggaagtc aaattcagat actacctgtt
     2821 ccaggctggt cgtctcgttg cctgtcccga atacgggcag tgtgcgcaga tcattgatcc
     2881 ggaatgaatc cagctggtta tttttcaata ggataggaag tacctgatct ccctgccggt
     2941 attctcccaa agtcattccc gtggtaccga tctgaatgct ctgtgccatt ccctgtcggg
     3001 atacacccag cggttgtgcc cgttccgggc tgtaaaccgg tttccagacg ggtatcttgt
     3061 ttccccacga attgcggata ttaattaaat ccggattctg gtgcataatg gctattgcct
     3121 gattggtaag tgatacaagc gtatccacat tcggaccgat aaagccgatt tcgatagccg
     3181 catccactgc gggggacagt ttgaacaagc tggtccgtgt gattgcactc ggataattgg
     3241 ctttcatata tccgtcaaaa tcttcttcgt attctttcgt atatttactg tctgtcagtt
     3301 cgacgagtac attggcaaaa ttcggtttcg gacctacgga agtggaggca aggtaatacc
     3361 ttagcggggt gctgccgaat gtgatggata ccttttttac ttccggctgc ttcgccaggt
     3421 gctcttctac cgatttcatc tctttcacta cgtcattgat gctgtatccg tccggataga
     3481 atacatccgc ccggaaataa ggcttatcga gcgacgggaa gaagttctgc ggcatcgttc
     3541 ccataataat gagcgagatg atgaagagga tcaccatgga taccagtgtc actgctttct
     3601 tgcggatcaa tactccgaga acggaagcga acttatgata gaacggcttg tcgtatggat
     3661 ctttcgtgct gtcgcctgtt ttggctttca gaatgaaatt tccgaatacg gtagtctgcg
     3721 tcagggcaag tacccagctc agtcctagtg aaatggcaag taccacaaac agcggtttta
     3781 cgatttccgc tacagcagag ggagcaaggt aaagcggcag gaaggagcag atggcaatga
     3841 aagttgctcc gagcaagccc cattgtggtc cggttgctcc gtctatcagg gctttccgtc
     3901 ggtttatacc tcgggcaatg gctatttggg cgttgtccgt cactacgatg gcgttgtcca
     3961 ccagcatacc catggcgatg ataaatcctg ccagggacgt tctgttgagt ccgacgccga
     4021 agaaagacat gatgagcagt gtacctccga tagagaaaat cagcgaagag ccgatgagca
     4081 gaccggcacg gagtcccatc accagcatga taatgacaat cacgatcagg atggattcga
     4141 tcaggttgat gataaatccg ttgttggctt cgttggcgat ctcgttttcg aggtagaggc
     4201 tttgcagttc cagtcccaca ggcatgaggg ggaggagctc gttcagtttt acttttacgt
     4261 tctcacccgt ctgcactaca tctctttgcg ggtcggtgga aacaccgatg ccgatagccc
     4321 gtttcccgtt cacatgcatg atgttggatg gagggtcgag ataacctttc tcgatcacgg
     4381 ctatgtcgcc cagtttcacc tgtccggctt tggtggtgat tacctggttg cggatatcgt
     4441 ctatgttggc atacattccg ttggctgtta cccgtaactg ctgtacgcct gcacggattt
     4501 ctccggtgtt gataatctgg ttcnnnnnnn nnntgcgatt gcagaaggtt ggccagctgt
     4561 ttgggatcga ttcccattcc caccagtttg ttggtagaaa cgaagatgtt gactacttcc
     4621 gtctgtacgc cgaacagtgc tactttcatc acgccgtctg ctgtgacaac ctgcgtcttg
     4681 atcctttccg cccagttacg catttcctca taagtgaagc cgtcatctgc cgtcagtccg
     4741 taataaatgc cgaatacgtc gccgaaatca tcggagacgg tcggggtgga agcaccgctg
     4801 ggcagctgcg gctgaatatt gagcactttg cgtcgcagtt cgtcccattt ctgagggatg
     4861 gaactggcgg aaagtgaggg ttgcagttcg aacgtgattt tggagagccc gtacatggac
     4921 tctgatttta tcttgtacac gccgctcata ctttgtatct cacgggagat aggctctgtg
     4981 atcagccgtt ctacttctgc cggttcggct cccggatagc gtgtcatgat gaccgctgat
     5041 ttgataacga agggggcatc ttctttcttg cccagctttc cgaaggaggt aatacctcca
     5101 atcagcagta cggcaaggaa gaaatagatg atcttcgtgt tatccagtga atattttgct
     5161 aagttcattt gtctattgat ttaatacttt ctccttctac caactggtat actcctgcta
     5221 tgacgatttg ttctccgggt ttcagtcctt cggacacgag tacttgcgcc tctcctgtgg
     5281 gggcattgac gacgattttg cgtttgtgca ctttgttgtc ctctactacc cagacataca
     5341 tgttgtttcc gtcactttcg ccgaaaacag cactgagcgg gatgattgtc cagctatcct
     5401 gcaccagtgg gcctacatcg gctgtgaaac ggatgctgca agtgaagccg ggcttcacgg
     5461 catataagtc ccggtcgaat gaagggtcgt cgatagtgat gctgaccgga atacccgttc
     5521 cttcggtgga tatgtccaga tattcctcca gtctcgcctt gaacacatgg cccttgaagg
     5581 tatcaaactc tacaaggaaa cggggatctt tggcacggag gagataaaga tatgcatccg
     5641 gtatggtgaa cttgatacgc aggttctgtg tgttgaccag ttgtacgatc ccttctcctg
     5701 aattgacacg ctggtagttc tccaccagcc gcttctcgat agaaccgtcg aaaggggccg
     5761 tcagtttggt gtcacgcatg ttgttgctgg acagttcgta ctccgatttt gctttctgat
     5821 aattggaaag gctgatttca tactcctgca cggagatcgc ttgccgggag agcaggcgct
     5881 tgttgcgttc cacttgtgcg gaagccgttt cgtaggcaga cttggtggca gcatactgca
     5941 atgcgatatc tctgggatcg atagctgcaa tcagttgccc ttttttcact ttctctcctt
     6001 cgataacagg caggctgatg atctgtccgc tgacgcggaa tgccagtttg acatactcca
     6061 ctgcttctac aatgccggag aagtcttttc tgattactga ccttgattcg acaatagttg
     6121 tcttaacagg tcgggtggcg ggtgccgtca tctctttttt ttgcccgcag ccttgaaata
     6181 ggatggctgc gagtgcaatc acatagatat ttttcataag tcgttcattg tttgggaagt
     6241 aaacaatttg atacttgact atgttcagta gagacgggta tattagaaat gtgaaattag
     6301 tatcaacatt aaaggaaaat gattgtttat agataaaaaa tgccttttct gttgatttta
     6361 tcagagatta ttcccacttt tgcaccgcac tagtattaca gtcgcggaat gcgatatgag
     6421 aatttaattc tcgaatttaa gctacgagca tgtgggaata tgctcgtggc ttccttagat
     6481 atacggttct gtcccccgtg tggagcgtta atgcgcccac tgtatctcat ccctcgtgga
     6541 ctgtaatatg tagtgcaacg ggtcagcagg accgtctttt ttgcctgctg aatattatta
     6601 tatataatag gaagtatttc tcctgaatag tactatttaa taaaccatca tttttcagga
     6661 gatcagacaa tataatggta tggtatattc ccttaactat accattttta tattacctgg
     6721 taatagttcc ccttagccag ttaatatacg gaccgcacta ctctgtgaag aatggtgcgg
     6781 tcctttagtt tatctatgaa acgaaaaaga ggaaatttcc aaccggaaat ctcctctttt
     6841 ttcatcttaa cgaaagattg aattatttct tnnnnnnnnn ntcttcttac ggtcaccgta
     6901 acggctcatg aacttatcaa cgcgacctgc agtatctacc aatgtagatt tacctgtata
     6961 gaacgggtga gaagtgttag agatttcaat cttcagcaac ggataagttt caccttcgaa
     7021 ttcgatggtt tctttagttg ctacagttga tttagacaaa aacatatcac catttgacat
     7081 atctttgaat actaccggac ggtatgattc tggatgaagg ccttttttca tttcagtatc
     7141 tgttttttta atttatattc tgttactatt ttggtaagaa atagtgtaat ggtcattttc
     7201 agagcgcaaa gatagcacat ttctccggaa tagaaaaaac tttgctgaaa aaacttctgt
     7261 gaattatgct atttctatga attatatgat tggcacgaaa agaatgtctt gtgcttttta
     7321 tggtataata cctgttttgg gatagaacct ttcagccgtt tatttgctag gtggacatta
     7381 caatctaatg tcagacccgc ttacggatga atatttgctg atcgatttaa acctttttct
     7441 attatatttt tctttccgat gctcgttatt cggtggataa tgcttacttt tgcgtagaat
     7501 tttaattcac taacaataaa ctttaaacaa aatggttaat tacaaagact taggattggt
     7561 aaacacaaga gacatgtttg ctaaggctat taagggtgga tacgctatcc cagcattcaa
     7621 cttcaacaat atggaacaga tgcaggctat catcaaggct gcagtagaaa caaaatctcc
     7681 ggtgattctt caggtttcta aaggtgctcg tcagtatgct aacgctactt tgttgcgtta
     7741 catggctcag ggtgctgtag agtacgcaaa agaattaggt tgcgcacatc ctgaaatcgt
     7801 tcttcacctt gaccacggag atacttttga aacttgcaaa tcttgcatcg attcaggttt
     7861 ctcttcagtt atgatcgacg gttctcatct tccttacgaa gaaaacgttg ctttgactaa
     7921 gaaggtggtt gaatacgctc atcagttcga cgtaacagtt gaaggtgaac ttggtgtatt
     7981 ggcaggtgta gaagatgaag tttcttctga ccaccacaca tacactgacc ctgaagaagt
     8041 aatcgatttc gctactcgta caggttgtga ctcattggct atctctatcg gtacttctca
     8101 cggtgcttac aagtttactc cggaacagtg ccacatcgat ccggctaccg gtcgtatggt
     8161 tcctcctcca ttggctttcg aagtattgga tgctgtaatg gaaaaacttc cgggattccc
     8221 tatcgtactt cacggatcat cttcagttcc tgaagaagaa gttgaaacaa tcaacaagtt
     8281 tggtggtgct ctgaaagctg ctatcggtat tcctgaagaa gaattgcgta aagctgccaa
     8341 gtctgctgtt tgcaaaatca acatcgactc agactctcgt ttggctatga ctgctgctat
     8401 ccgtaagact ttcgctgaaa aaccagctga attcgaccca cgtaagtatc ttggtccggc
     8461 tcgtgacaac atggaaaaac tgtacaagca caaaatcctt aatgtgctgg gttcagacaa
     8521 caaattggct gaataatcac agattatcct attatataga aaggctgcaa tcgtttgacg
     8581 gttgcagcct ttttacgtaa tattctctat ctgcttattc cggtttctga gcgggcacat
     8641 ttcctcccaa gaagaaatct tctatctttt gcttactttg aatgtctttc agccagttag
     8701 ctgcagcatt ataataattc ttagtgccta aaacgagttc gcctcgttcg tttagtttcg
     8761 cttcttcttc cttatcttct ttcgggcgtg tttttaagaa tgcttccaga cagcgttcgg
     8821 tgtttttctt gtctttcagc gaatagaaat aaatgaaagc catatcatag agcagcttat
     8881 gattttgttt atcgtatttc cggtagcgtt ctctgatcga ttcaatctgc tctttaggca
     8941 tctgtgccat tttgtagcag tcggtcatgc caatatagag ccgtaccata ttactgtctt
     9001 tgggaatagt cagatcaagc gctttttcga gatactctac gcctaacttc ttccatgaag
     9061 tcttggcgca ggcacggccg agataataaa gcaggtttac gttttcagga tcatgttttc
     9121 gggcggcttc cagaaagtca tgtgcttcgt aatatttctc ttccgcataa tagctgatac
     9181 ccagataata acaggtatga aaagaactgt cgccctggct caccaggtat tcataacgct
     9241 ggatagcggt aggataatcc ttattcagac aatatgccag tgcattctgg cggttgacag
     9301 cgatgttggt ggtgtcaatc tgccgatatt tctccgtggc ttcaattgct tcgttgaaat
     9361 aagaaccggc tatgttcagt gcggcgagct tggcggcggc aagatagtcg tcggggtatt
     9421 tctcctgtat attatagtag caccccgtgg cggggagaag ctctcccata ccttcgaaac
     9481 tttgggcctg cagatgcaag gcgatggcgg aactgtcttt ctctgtcatc agactacttt
     9541 ctcctaaagc atcctgaaac ttctgtaaag agagcagtag tccgatgtat tgaatacgca
     9601 catatttgtt ttccggattc agatcgagtg cctgttcata atatttcagt gcctgttggt
     9661 atttggccaa tgaacggcag cattcggctg cttcgatata tgcacgggta ttggcagtgt
     9721 cattggttat gatttcctga taagtggaaa gtgcttctgt attcatccca agtccccgtt
     9781 gtgctttacc tttttgcaag agtaggggaa ttgtcggctt ttctttggca atgagagtga
     9841 gagctgcctc gtaatcgtag tttgctattg cttcctgaac atgattgatg cgctgcgcca
     9901 tcaccagggt ggtggtacaa aggaaggcga ggagaataat ccgtttcata aatatttatt
     9961 ttagtgtgtc gtaacaaaga cgcaagatgc taaaaaatat cgtatttacg aattattcgt
    10021 agcctttttg gaatagatta acggaatgat aagagaagat aacataatga taagtgcgga
    10081 tattgcatct aaaacagcaa tatccgcacc taatattttg tcccggcatt ccgaatggaa
    10141 gcctgacagg ggcaccttgt ccctacatta agaatcctaa caggataccg gcagcaacag
    10201 ccgaaccgat tacacctgct acgttcggac ccatagcgtg catcagcaag tagttggttg
    10261 gatcatattc cagaccgaca acttgtgaga tacgtgcaga gtcgggaacg gcagatacac
    10321 ctgcattacc gatcaacgga ttgatcttat tgcccttctt gaggaagagg ttgaagatct
    10381 taacgaagat cacacctgat gcggtagcaa tgataaatga cagtgcaccg agggcaaaga
    10441 tcttgatgga gtcgagtgtc aggaactcgg aagcctgagt agaggcacct actgtcaaac
    10501 ctaacaggat agtgataacg tcaatcagcg gaccgctggc tgtgttagcc agacgacggg
    10561 ttacaccact ttctttcaac aggttaccga agaacagcat acccagcaga ggcagaccgg
    10621 aaggaaccag gaagcaggtc agcaacagac cgataatcgg gaaaatcact ttctctgtat
    10681 gagaaacggc acgtggcggt ttcatacgga taacgcgttc gtgtttggtg gtgagcagac
    10741 gcatgatagg cggctgtatc accggaacta acgccatata ggagtaggcg gataccgcaa
    10801 tggctcccat taagttaggt gccagcttgg acgaaaggaa gatagccgtc ggaccatctg
    10861 ctccaccgat gataccgata gcaccggcct gcatcgggtc aaatcccatt tccaatgcga
    10921 tcatgtatgc accgaagata ccaaactggg cagccgcacc gatcagcatc agcttcggat
    10981 tggagattag cgccgagaag tctgtcatgg caccgatacc taagaagatg agcggtggat
    11041 accagccgga cgttactccc tgatacaata tgttcaatac agaaccttct tcatatatac
    11101 cgacttttag tccggcgtcc atattgaaag gtatattacc gatcagaata ccgaatccga
    11161 taggaattaa caacatcggc tcgaactctt tggctacagc taagtaaata aagcctaaac
    11221 cgataatgat catagcaata tgtccacctg tcgcgttggc aaatcccgtg taggtccaga
    11281 aatcggcaag gttatttcct aaaaagttaa taaaatctcc catattattc aataattacg
    11341 aggtcattac cttcaagaac agaatctccc ttgttgacat tgatggcagt cactttaccg
    11401 tctttgtctn nnnnnnnnng ttcagacgtg tgctcttccg atcttaccgt ctttgtctgc
    11461 attgatattg ttttccatct tcatggcttc caatataatg atagtctgtc ctcttttcac
    11521 tgtatcacct acatttactt tgatgtcaag gataacgcct ggcagtgggg acttaacgcc
    11581 tgatttgccg gtagaaggag cagccggttt tactaccggt gtggtaggag cagccggtga
    11641 gttaggcata gggcgtacta ctgccggttt gggagtagct ttcggttgtt tctccatttc
    11701 tactttgtaa tgcgtaccgt tcacttctac atgagcgata ttatcttcaa tatctccgat
    11761 ggttactttg tatgagttac cgttgatttt atatttatat tctttcatcg ttttatcttt
    11821 ttagggaatg atttactttc tgttaggatt ttcacgcaag gtgtaaatct tcgaactcca
    11881 cggtgaataa ctgcgcttca cacgagtgat ggtcagcacc gtttcttcta cgtcgtgtac
    11941 ctcatcctgc atttcgtgta atgccattga aatagcagca taaacttcac ccggagcctg
    12001 tgaaagctct ttcgcttcga ctttatcgat gcctttagcc ttcaccgcat tgcgtctgct
    12061 caggttgaca gcaactttac ctaccacctt gaaggcaatg aagagaagaa tcaatccgca
    12121 gaatactacg ctcatggctg aaatagacat accgataccg actgagtcat gttcttcgaa
    12181 cttttccatc ttggcattac tgtcaagggt tttgttgttc gtgctcgggg ttacgtattt
    12241 gtctttgctt ccgcctttta cttcccagtc tgctgctccg tcgcttatgc gtgcataaga
    12301 ctggttggga cctaaagttc ctgctggtat gacaacttga tcaagtagct ttctgcctga
    12361 atcaaaaaga ccgacccaat tggctgtttc gggattcagt ttgaagctgg tatggaaggt
    12421 tccacgatta ggttcgccat ctgcccaaaa taacgcatgt tggcgtggct ttactaatgt
    12481 aagtatgtca ccttttggga taaaataggt tactgtatcg cccggctggc tgcttacttt
    12541 caataaacaa gctgctaagt ctgcgctacc gtatgatttg ttgaatattt caatccatgc
    12601 actgtgcaag ccgtagtcat cctgaaagtt gttttgattg tctatcagga cttcattcag
    12661 caatagctta ttgttcgact tttgctctcc gcaggaagtc aatccaatca gcaacagcag
    12721 agaaaggaat attccgattt tggttttgtt cataatcgtt cttgttttaa tgtgaaaagt
    12781 tggattacaa cggaatatta ccatgtttct tcgccggatt agacagtttc ttagtctgca
    12841 actgctgcaa agcacggatc acgcggaaac gtgtgttacg gggttcgatg acatcatcga
    12901 tgtaaccata cttagctgca ttataagggt tggcaaacag ttttgtatat tctgcttctt
    12961 tttcggcaag gaactgagcc ggattttcct ggtctttggc ttcacgcgcg tacaatactt
    13021 ctactgcacc tgcaccaccc attacagcga tttcagctgt tggccaagca tagttcatgt
    13081 caccacgaag ttgtttacaa ctcatcacga tgtgagaacc accgtaagat ttacgcaatg
    13141 tgattgttac tttaggtaca gtagcttcac cgtaagcata cagcagtttg gcaccatgaa
    13201 ggatgacgcc attgtattcc tgacctgttc ccggaaggaa tcccggtacg tctaccaacg
    13261 acacgatagg gatattgaaa gcatcgcaga aacgaacgaa acgtgcgcct ttgcgagatg
    13321 cgttgctgtc gagtacaccg gcaaggaatt taggctgatt ggctacaata cctacagact
    13381 gaccgttgaa acgggcaaaa ccgataatga tattcttggc atagtctttc tggatttcca
    13441 ggaattcgcc gttgtctacg atagcgctga taacctcgta catatcatac ggtttgttgg
    13501 ggctgtcggg gataatatcg ttcagagaat cttccagacg gtcgatcgga tctgtgcaat
    13561 ccacgtatgg agcttcttcg aggttgtttt gaggaatata gctcagaagt gtgcggatca
    13621 atgccagacc ttcttcttct gttttggcag tgaaatgagt aacacccgat ttggtagagt
    13681 gaacgcttgc tccgccgagg ttttcctggc ttacgtcttc accggttaca gttttcacta
    13741 ctttcggacc tgtaaggaac atataagaag taccttccat catcagtgtg aagtctgtca
    13801 gtgccggaga ataaacagca ccgccggcac aaggcccgaa gataccggaa atctgcggaa
    13861 tgacacccga agcgaggata ttgcgctgga agatttctgc gtaacctgcc aaagcgttaa
    13921 taccttcctg gatacgtgca ccgcccgagt cattgatacc gatacaagga gcacccatct
    13981 tcattgcctg atccataatc ttacagatct tcagtgacat tgtttccgac agtgaacctg
    14041 cagtaacggt aaagtcctgt gcaaaaagat atacgagacg accttcgata gtaccgcaac
    14101 cggttactac accatcaccc ggatagtgct ttttctccat gccgaagttc gtgcatctgt
    14161 gctcaacgaa catgtccatt tcttcgaagc taccttcatc caacagcatg gctatacgct
    14221 cacgcgctgt gtatttccct ttttcatgtt gcttcgcaat tgctttttcg ccgcctccga
    14281 tgcgtgcaac ggcacggcgt tcaataagct ctttaatttt ttcaagttga ttactcatga
    14341 gttcttgttg tttttttaga gtttatgatt agtgttcgca gagttctgtc agcacaccca
    14401 gtgttgattt cgggtgaagg aaagcgatgt tcagaccttc ggcacctttg cggggagcct
    14461 tgtcaatcag acggatttct ttgctttctg cttctgccaa agcattagct acgccatctt
    14521 ctacggcaaa tgctacgtga tgaacacctg cacctttgtt ttcaataaat ttagcaatgg
    14581 tgctttcggg gcaagtcggc tccaacaatt cgatttttgt ttcacctacc tttaaaaaag
    14641 cggttcttac tttttgatct tctactgttt cgatgttgta acatttcaga cccaatacgt
    14701 tttcgtagta aggaagggct tcttcgatgc tttttacagc aatgcccaga tgctcaatgt
    14761 gtgaaatctt cataactata tttttttata tggtttaatt atgtgcttat atggcataaa
    14821 acagcacaaa gaaagacatt tcttgtctaa tgaagaaata tttctgcatt taattattgg
    14881 ggaataaagc ataaaaaatg ctccggatgg gtgacaaaga cgggttttgt aatcttgaga
    14941 ttacatttag acataaaact tgaccagaag attattcagc catggccagc tgatacggaa
    15001 ccagcggcgg gtactgcttt gtttgcctcc gaaacggagt acgaaatcac gataaccatg
    15061 cttgcggaag ggaagtccta catccatgaa ctccatgtga cggaatcccc gttcatgggc
    15121 atcttcaagt gctttccata ctgccagtat gccgggtgac tgcagtgcat aggtctttcg
    15181 cattcctcct gaaaaccaga taaaagcatt ttcgccggaa tagatgcaga cggagccgcc
    15241 gataatcttt tccttgtatt ttacgatgaa tatttttgcc tgttttcctc tgataagcat
    15301 gctgttcatg tggcggaaaa agtcattggc agggaaatat ctccgtattc gtgaagaata
    15361 aactttgtgc agcatccgcg agaattcctt aatctcttcc accgtatggg cttctactac
    15421 tttggctccg tttttgagcc ctttccggat ctgacggata cgtgatgggc tgaaacggtc
    15481 ttccgctttc tgcgtactat gcagagagtt acggacacgc agccagttga ccggaaaaaa
    15541 gtcgttcttt cggaagaaac ggtaaccgaa catggaatta tccagattgc ggaattcaat
    15601 aagaatgcag gtgcgtgatg cttcttgtgt gagatgctcc agcatttcac cgaaaatttc
    15661 ttcctccttc tctttacttg ccggtagaga agtgtccaga aattcacctg caccatatac
    15721 cacacattgt ttgacaagag aggagggaag ccactttttg gtcttgcgta tggcggcaag
    15781 caggcgtgct acaggtctgc cttcttctgt tgccactatc agtagcgggg tatatcccgg
    15841 agtcgattca tagatctgaa acaactcctt ggaatgaaaa gtattggttc ccggtaaatc
    15901 aggaatgtct tttccgcgat aatatgttgt tagtttaagt ggcatccaaa tacaaattta
    15961 cactttttat tcttcattca acaataaaaa agagaatttg ttggcttagc ctaaaatttg
    16021 tctttttatc ctttgcatat atttgaggaa aaaaaggctt ggaaaagcga atttttgtat
    16081 tattgtcgtc ctttgtgagt acagaagtaa aatggaaacg tctatataaa agattatgct
    16141 aattgtattt tactaaacaa aggaaaatta atattaactt taaattaaaa cgaatgagag
    16201 agaatgcatt tgttgaagcg tggaagacac agcatagacg cgtttccatg attttagggc
    16261 tgactttatt gtgtgcccct tctgccatat ctgtttatgc agaaaatggt gtgaatgata
    16321 ttactgtgca agccgtcatg cagacaaaga cagtgaagat cggaagagcg tcgtgtaggg
    16381 aaagagtgta ggctatagtg t
//
